Relevant bibliographies by topics / Breast cancer; mammography screening; over-diagnosis

Academic literature on the topic 'Breast cancer; mammography screening; over-diagnosis'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Breast cancer; mammography screening; over-diagnosis"

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Łuczyńska, Elżbieta, Marta Pawlak, Tadeusz Popiela, and Wojciech Rudnicki. "The role of ABUS in the diagnosis of breast cancer." Journal of Ultrasonography 22, no. 89 (April 13, 2022): 76–85. http://dx.doi.org/10.15557/jou.2022.0014.

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Breast cancer, which is the most common cancer in women, is a major problem both in Poland and worldwide. Mammography remains the primary screening method. However, the sensitivity of mammographic screening is lower in women with dense glandular breasts due to tissue overlap and the effect of the glandular tissue obscuring the tumor and the fact that tumors and glandular tissue show similar X-ray absorption. Consequently, other methods are being sought to increase breast cancer detection rates. Currently, the most common and used methods are ultrasonography, magnetic resonance imaging and advanced mammographic methods (digital breast tomosynthesis and contrast-enhanced spectral mammography). Despite many advantages and superiority over mammography in dense breasts, they also have many disadvantages. Ultrasound is operator-dependent and the other techniques are expensive or not widely available. The Automated Breast Ultrasound Service (ABUS) technique appears to be a good option in terms of both effectiveness and lower cost.
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Kuhl, Christiane K., Heribert Bieling, Kevin Strobel, Claudia Leutner, Hans H. Schild, and Simone Schrading. "Breast MRI screening of women at average risk of breast cancer: An observational cohort study." Journal of Clinical Oncology 33, no. 28_suppl (October 1, 2015): 1. http://dx.doi.org/10.1200/jco.2015.33.28_suppl.1.

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1 Background: Breast-MRI is currently recommended for screening women at high-risk of breast-cancer only. However, despite decades of mammographic-screening, breast-cancer continues to represent a major cause of cancer-death also for women at average-risk – suggesting a need for improved methods for early diagnosis also for these women. Therefore, we investigated the utility of supplemental MRI-screening of women who carry an average-risk of breast-cancer. Methods: Prospective observational cohort-study conducted in two academic breast-centers on asymptomatic women at average-risk in the usual age range for screening-mammography (40 to 70). Women underwent DCE-breast-MRI in addition to mammography every 12, 24, or 36 months, plus follow-up of 2 years to establish a standard-of-reference. We report on the supplemental-cancer-yield, interval-cancer-rate, diagnostic accuracy of screening-MRI, and biologic profiles of additional, MRI-detected breast-cancers. Results: 2120 women underwent a total 3861 MRI-studies covering 7007 women-years. Breast-cancer was diagnosed in 61/2120 women (DCIS: 20, invasive: 41), and ADH/LIN in another 21. Interval-cancer-rate was 0%, irrespective of screening interval. Forty-eight women were diagnosed with breast-cancer at prevalence-screening by MRI alone (supplemental cancer-detection-rate: 22.6 per 1000); 13 women were diagnosed with breast-cancer in 1741 incidence-screening-rounds collected over 4887 women-years. A total 12 of these 13 incident cancers were diagnosed by screening-MRI alone (supplemental-cancer-detection-rate: 6.9 per 1000), one by MRI and mammography, none by mammography alone. Supplemental-cancer-detection-rate was independent of mammographic breast-density. Invasive cancers were small (mean size: 8mm), node-negative in 93.4%, ER/PR-negative in 32.8%, and de-differentiated in 41.7% at prevalence, and 46.0% at incidence-screening. Specificity of MRI-screening was 97.1%, False-Positive-Rate 2.9%. Conclusions: MRI-screening improves detection of biologically relevant breast-cancer in women at average-risk, and reduces the interval-cancer-rate down to 0%, at a low false-positive rate.
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Kosar, Sumreen. "Harms and Benefits of Mammography Screening." YMER Digital 21, no. 05 (May 2, 2022): 7–16. http://dx.doi.org/10.37896/ymer21.05/02.

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Mammography is one of the most technically challenging areas of radiography, required high spatial resolution, excellent soft tissue contrast and low radiation dose. Mammography screening for breast cancer is worldwide available. Early detection of breast cancer through screening can lower breast cancer mortality rate and reduce the burden of this disease in the population, the benefits and harms of mammography screening have been debated in the past years. This review discuss the benefits and harms of mammography screening in light of findings from randomized trials and more recent observational studies performed in the era of modern diagnosis. The main benefit for mammography screening is reduces the risk of dying from breast cancer. Reduction vary from 15 to 20% in randomized trials to more recent estimates of 13 to 17% in analyses of observational studies. UK data of 2007 shows that for 1,000 women invited to biennial mammography screening for 20years to 50years age, 2-3 women’s are prevented from breast cancer. Main harm of mammography screening is the over diagnosis of breast cancer. 15 women’s over diagnosis for every 1000 women invited to biennial screening for 20 years from 50 years age. In an era of limiting health care services, screening services need to scrutinized and compared with each other regard to effectiveness, cost effectiveness and harms.
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Allison, Kimberly H., Linn A. Abraham, Donald L. Weaver, Anna NA Tosteson, Tracy Onega, Berta M. Geller, Karla Kerlikowske, et al. "Tissue sampling frequency and breast pathology diagnoses following mammography: Time trends and age group analysis from the Breast Cancer Surveillance Consortium (BCSC)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 559. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.559.

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559 Background: Pathology diagnoses in a well-characterized population of women can be used to identify tissue sampling and diagnosis trends following mammography. Methods: Screening and diagnostic mammography, patient characteristics, and pathology reports from the BCSC performed from 1996-2008 were identified. Diagnosis was based on the most severe pathology interpretation in the same breast within 60 days of a post-mammogram tissue sample. Age, mammogram year and type, breast density, and family history of breast cancer were evaluated for associations with tissue sampling and most severe pathology diagnosis. Results: 4,022,506 mammograms (88.5% screening; 11.5% diagnostic) were performed in 1,288,886 women; 76,567 (1.9%) were followed by tissue sampling (1.2% screening; 7.1% diagnostic). Tissue sampling frequency following diagnostic mammography increased over time in women over 50 but remained stable following screening mammography. The frequency of invasive cancer increased with age and was more common following a diagnostic (29.3%) vs screening (19.8%) mammogram; the frequency of high risk lesions (ADH; lobular neoplasia) was highest in women aged 50-59. For tissue sampling following screening mammograms, the frequency of DCIS increased over time while benign diagnoses decreased. No significant time trends were noted for diagnoses associated with diagnostic mammograms. Women aged 40-59 with dense breasts and a tissue sampling following screening mammogram had a significantly higher frequency of DCIS (40-49: 4.8% vs 3.2%, P< 0.001; 50-59: 7.0% vs 5.7%, P=0.007). Women aged 40-59 with > 1first degree relative with breast cancer vs none that had a tissue sampling following screening mammogram had a significantly higher frequency of invasive cancer (40-49: 11.4% vs 9.4%, p=0.008; 50-59: 19.8% vs 18.2%, p =0.086) and DCIS (40-49: 6.2% vs 4.0%, p< 0.001; 50-59: 8.2% vs 6.2%, p< 0.001). Conclusions: There was an increase in DCIS and a decrease in benign diagnoses in tissues samples after screening mammography over time. No trends were seen following diagnostic mammography. DCIS was also more frequent in women with dense breasts.
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Sener, Stephen F., David J. Winchester, David P. Winchester, Raffael Kurek, Gary Motykie, Carole H. Martz, and Sarah Rabbitt. "Spectrum of Mammographically Detected Breast Cancers." American Surgeon 65, no. 8 (August 1999): 731–36. http://dx.doi.org/10.1177/000313489906500807.

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Mammographic screening of women at both ends of the age spectrum presents a number of challenges. The purpose of this study was to characterize experience with mammographic detection of breast cancer. The two goals were 1) to establish the cancer detection rate of screening mammography and 2) to compare the tumor size of cancers found by mammography, physical examination, or both modalities. From January 1994 through June 1997, data on 609 consecutive female primary breast cancer patients were collected concurrent with definitive surgical therapy. The method of detection was determined by the surgeon, after reviewing mammogram and physical examination. Screening ultrasound was not used. For the 184 patients under 50 years of age, 53 (29%) cancers were detected by mammography only and 48 (26%) by physical examination only. Women under 50 years of age had fewer cancers detected by mammography only (P < 0.001) and more cancers detected by physical examination only (P = 0.0014) than those over 50. With increasing age, the proportion of women with ductal carcinoma in situ decreased (P = 0.004), and the proportion with T1c or T2 tumors increased (P = 0.006). We conclude that 1) when examining women under 50 years of age, the surgeon must be clearly focused on the double-edged sword of screening mammography in this age group, and 2) community cancer programs should encourage annual screening of women over 40 years of age but focus on those over 70, without an arbitrary upper age limit.
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Bancej, C., K. Decker, A. Chiarelli, M. Harrison, D. Turner, and J. Brisson. "Original Paper: Contribution of clinical breast examination to mammography screening in the early detection of breast cancer." Journal of Medical Screening 10, no. 1 (March 1, 2003): 16–21. http://dx.doi.org/10.1258/096914103321610761.

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Objectives: As the benefit of clinical breast examination (CBE) over that of screening mammography alone in reducing breast cancer mortality is uncertain, it is informative to monitor its contribution to interim measures of effectiveness of a screening programme. Here, the contribution of CBE to screening mammography in the early detection of breast cancer was evaluated. Setting: Four Canadian organised breast cancer screening programmes. Methods: Women aged 50-69 receiving dual screening (CBE and mammography) (n=300,303) between 1996 and 1998 were followed up between screen and diagnosis. Outcomes assessed by mode of detection (CBE alone, mammography alone, or both CBE and mammography) included referral rate, positive predictive value, pathological features of tumours (size, nodal status, morphology), and cancer detection rates overall and for small cancers (≤10 mm or node-negative). Heterogeneity in findings across programmes was also assessed. Results: On first versus subsequent screen, CBE alone resulted in 28.5-36.7% of referrals, and 4.6-5.9% of cancers compared with 52.6-60.1% of referrals and 60.0-64.3% of cancers for mammography alone. Among cancers detected by CBE, 83.6-88.6% were also detected by mammography, whereas for mammographically detected cancers only 31.7-37.2% were also detected by CBE. On average, CBE increased the rate of detection of small invasive cancers by 2-6% over rates if mammography was the sole detection method. Without CBE, programmes would be missing three cancers for every 10,000 screens and 3-10 small invasive cancers in every 100,000 screens. Conclusions: Inclusion of CBE in an organised programme contributes minimally to early detection.
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Liu, Ying, Aliza Gordon, Michael Eleff, John Barron, and Winnie Chi. "Improved outcomes among breast cancer patients with more frequent mammography screening." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e19146-e19146. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e19146.

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e19146 Background: Guidelines for optimal frequency of screening mammography (annual, biennial, never/choice of patient) vary by professional society, due to mixed or insufficient evidence regarding its benefits and harms. Little evidence exists on the impact of screening frequency, rather than any screening, on health outcomes. In this study, we measured differences in cancer stage at diagnosis, treatment rendered, mortality, and cost of treatment for women with different numbers of screenings prior to breast cancer diagnosis. Methods: Utilizing administrative claims, we identified 25,492 women aged 44 or older with various numbers of mammographic screening ≥ 11 months apart during the four years prior to their incident breast cancer diagnosis from 2010 to 2018. Outcomes were assessed during the six months following diagnosis. Regression models were used to compare women with differing numbers of mammograms (0, 1, 2, 3, or 4/5), adjusting for demographic characteristics and baseline comorbidities. Results: More screenings were associated with less advanced cancer at diagnosis, higher rates in lumpectomy and radiation, lower rates in mastectomy and chemotherapy, lower costs and mortality within 6 months post diagnosis (Table). Results were similar in a subgroup with only women aged 44-49 at diagnosis (not shown). Conclusions: Increased frequency of screening mammography is associated with earlier breast cancer stage at diagnosis, less toxic and invasive treatment, lower mortality, and lower cost, including for women under age 50. [Table: see text]
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Calinescu, Gina, Corina Grigoriu, Athir Eddan, Nicolae Bacalbasa, Irina Balescu, Bianca-Margareta Mihai, Roxana Elena Bohiltea, and Claudia Stoica. "Breast density and breast cancer." Romanian Journal of Medical Practice 16, S7 (December 30, 2021): 29–32. http://dx.doi.org/10.37897/rjmp.2021.s7.9.

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Breast density is increasingly recognized as an independent risk factor for the development of breast cancer. It has been shown to be associated with a four-to sixfold increase a woman's risk of malignant breast disease. Increased breast density, as identified on mammography, is known to decrease the diagnostic sensitivity of the examination, which is of great concern to women at increased risk for breast cancer. Dense tissue has generally been associated with younger age and premenopausal status, with the assumption that breast density gradually decreases after menopause. However, the actual proportion of older women with dense breasts is unknown. Unfortunately, mammography is less accurate on dense breast tissue compared to fattier breast tissue. Multiple studies suggest a solution to this by demonstrating the ability of supplemental screening ultrasound to detect additional malignant lesions in women with dense breast tissue but with negative mammography. Improved screening methods for women with dense breasts are needed due to their increased risk of breast cancer and of failed early diagnosis by screening mammography.
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Scott, Anthony M., Madison G. Lashley, Nicholas B. Drury, and Paul S. Dale. "Comparison of Call-Back Rates between Digital Mammography and Digital Breast Tomosynthesis." American Surgeon 85, no. 8 (August 2019): 855–57. http://dx.doi.org/10.1177/000313481908500837.

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The effect of mammographic screening on the natural history and evolution of breast cancer treatment cannot be overstated; however, despite intensive and resource consuming screening, advanced breast cancer is still diagnosed frequently. The development of three-dimensional mammography or digital breast tomosynthesis (DBT) has already demonstrated greater sensitivity in the diagnosis of breast pathology and effectiveness in identifying early breast cancers. In addition to being a more sensitive screening tool, other studies indicate DBT has a lower call-back rate when compared with traditional DM. This study compares call-back rates between these two screening tools. A single institution, retrospective review was conducted of almost 20,000 patient records who underwent digital mammography or DBTin the years 2016 to 2018. These charts were analyzed for documentation of imaging type, Breast Imaging Reporting and Data System 0 status, call-back status, and type of further imaging that was required. Charts for 19,863 patients were reviewed, 17,899 digital mammography examinations were conducted compared with 11,331 DBT examinations resulting in 1,066 and 689 Breast Imaging Reporting and Data System 0 studies, respectively. Of the DM call-backs, 82.08 per cent were recommended for additional radiographic imaging and 17.82 per cent for ultrasound imaging. In the DBT group, only 39.77 per cent of callbacks were recommended for additional radiographic imaging and 60.09 per cent for ultrasound imaging. Our data suggest that DBT results in less call-back for additional mammographic images as compared with digital mammography. DBT may offer benefits over DM, including less imaging before biopsy, less time before biopsy, quicker diagnosis, and improved patient satisfaction.
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Walsh, Elaine, Michael P. Farrell, Fergal Gallagher, Roisin Clarke, Carmel Nolan, M. John Kennedy, Peter Daly, et al. "Breast cancer detection among Irish BRCA1 and BRCA2 mutation carriers." Journal of Clinical Oncology 30, no. 27_suppl (September 20, 2012): 59. http://dx.doi.org/10.1200/jco.2012.30.27_suppl.59.

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59 Background: High-risk breast cancer screening for BRCA1/2 mutations carriers with clinical breast exam, mammography and MRI have sensitivities approaching 100%. Even with intensive screening BRCA mutation carriers can present with self-detected interval cancers. We investigate screening practices and presentation among a cohort of Irish BRCA1/2 mutation carriers. Methods: Females with breast cancer belonging to kindreds now known to harbour BRCA1/2 mutations were retrospectively identified. Records were reviewed for BRCA mutation, demographics, breast cancer diagnosis, stage, histology and screening. We assessed screening modalities and whether breast cancers were diagnosed at screening or as interval cancers. Results: 53 cases of breast cancer were diagnosed from 1968-2010 among 53 Irish hereditary breast ovarian cancer kindreds. BRCA mutation status was unknown at time of diagnosis but subsequently confirmed. Detection method was identified in 50% of patients: 84% by clinical breast exam (CBE), 4% mammography, 4% MRI and 8% by a combination of CBE and mammography. Fifteen women (28%) developed second breast cancer; 9(60%) were undergoing screening, 2 were not and 27% were unknown. 22% were detected by CBE alone; 34% mammography; 22% a combination of mammography and CBE and 22% by MRI. In 41%, histology changed between first and second diagnosis. Two women developed a third breast cancer. In one, her second was an interval cancer despite being in a screening programme. Her third was radiologically detected. Conclusions: In this cohort of Irish BRCA1/2 mutation carriers almost 25% of second breast cancers were not detected by screening. 4% of cases were phenocopies and in 41% histology changed between first and second diagnosis. [Table: see text]
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Dissertations / Theses on the topic "Breast cancer; mammography screening; over-diagnosis"

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DeBoard, Ruth Ann. "Breast Abnormalities: Identification of Indicators that Facilitate Use of Health Services for Diagnosis and Treatment of Breast Cancer." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/195625.

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Problem: There is a lack of knowledge about women who are screened for breast cancer, have an abnormal finding on mammogram, and then do not return in a timely manner for diagnostics and treatment. Lack of follow- up likely constitutes delayed treatment and poorer outcomes. Delays may result in later entry into the health system with advanced disease, more extensive and expensive care, burdening resources. Late stage breast cancer likely results in poorer health outcomes or early death.Purpose and Aims: The purpose of this research is to describe contextual characteristics at the health delivery level as well as individual characteristics of women with abnormal mammography, and their association with use of follow- up health services. Particularly, this research examines the differences between women who are early and late responders after an abnormal mammogram.Population: The participants were a convenience sample of 380 women who participated in mobile breast cancer screening. A subset of women with inconclusive or abnormal mammogram findings was the focus of analysis.Methods: This research utilized a descriptive design with quantitative data collection through participant survey at mobile mammogram screening events in multiple urban and rural Arizona sites. Participants requiring further health care were followed by chart review. Analysis of correlations with the outcome variable: time to first follow- up appointment for recommended health care in women with abnormal mammograms was conducted.Findings: Data indicated the time to the first follow- up appointment ranged from 1- 110 days with follow- up for 77.4% of participants within 60 days, 6.5% within 60-90 days, and 16.1% without follow- up after 90 days. Significant relationships between contextual and individual characteristics and follow- up were found. Categories included organizational health system characteristics of geographic location, clinical breast exam and shared case management; individual characteristics of beliefs including value of health care; finance including out of pocket costs and perceptions of financial assistance; perceived needs including breast symptoms; and satisfaction with the last health visit and mammograms in general.Implications: Recognition of barriers to follow- up after breast cancer screening is important for development of interventions to improve outcomes and has implications for screening and treatment management programs, community health centers and private practice. Health disparity related to screening without adequate options for access to health care is ethically untenable. Nurses are well positioned to reduce barriers to health care.
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Cheok, Frida. "Participation in mammographic screenings in South Australia /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phc51843.pdf.

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Beckmann, Kerrilyn Rose. "Quantifying breast cancer over-diagnosis in an organised mammography screening program." Thesis, 2014. http://hdl.handle.net/2440/91778.

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Mammography screening is effective in reducing breast cancer (BC) mortality; however there are widespread concerns that it may also lead to over-diagnosis, i.e. the detection of BC that would not have emerged clinically in a woman’s lifetime had she not participated in screening. The extent of over-diagnosis due to mammography is contested, with published estimates varying from 0% to 54%. The principal aim of this research is to quantify the level of over-diagnosis of BC associated with population-based mammography screening in South Australia (SA). The following questions are addressed: (1) Have BC incidence rates increased following the introduction of screening in SA and is the increase greater than expected based on projections of pre-screening trends?, (2) Has the prevalence of key breast cancer risk factors also increased?, (3) To what extent does hormone replacement therapy (HRT) use affect breast cancer risk and screening outcomes?, (4) Are there any differences in the underlying risk of BC among screening participants and non-participants?, and the central question (5) What is the level of over-diagnosis due to organised mammography screening in SA? Questions 2-4 relate to the potential for estimates of over-diagnosis to be confounded by risk factor differences/temporal changes. A review of previous studies of over-diagnosis due to mammography screening is included, which highlights methodological complexities relating to measurement of over-diagnosis and offers some explanations for why published estimates vary to such a great extent. The first two questions were answered through descriptive analyses of BC incidence trends in SA from 1977-2009, as well as trends in the prevalence several key breast cancer risk factors collected via the SA Health Omnibus Surveys during 1991-2009 (alcohol use, body weight, HRT use) and Australian Bureau of Statistics (fertility rates and age at first birth). The effect of HRT on various screening outcomes (e.g. screen-detection rates, interval cancer rates, recall to assessment) was examined though multivariable Poisson regression modelling using individual person level data from BreastScreen SA, which included self-reported HRT use at the time of each screening episode. Differences in underlying risk of BC between screening participants and non- participants were investigated using 2012 South Australian Health Omnibus Survey data. Two different methods were used to quantify over-diagnosis. Method 1 used a case-control design to compare screening histories for women with and without BC. Odds ratios (OR) were determined across different time intervals after screening to allow for lead time effects and applied to background reference rates based on pre-screening incidence trends. Over-diagnosis estimates were obtained by comparing cumulative incidence with and without screening. Method 2 used a lead time modelling approach in which estimates of lead time duration and screening sensitivity, and screening participation data were used to adjust the background incidence rates (without screening). This was achieved by iteratively adding the number of cancers expected to be brought forward by screening each year, then subtracting this number from the pool of cancers in future years. Over-diagnosis was calculated by comparing the lead time adjusted cumulative incidence with the observed cumulative incidence. Studies presented in this thesis demonstrate that: (1) screening led to an increase in breast cancer incidence that was sustained beyond what was expected, based on projection of pre-screening incidence, however age-specific patterns suggest changing prevalence of HRT use have also impacted on incidence trends, (2) the prevalence of key risk factors also increased over this period, potentially contributing to an increase in background incidence rates, (3) HRT use among South Australian women is causally associated with increased risk of breast cancer which complicates estimation of over-diagnosis due to the marked changes in prevalence of HRT use, (4) women who participated in screening had a higher prevalence of breast cancer risk factors (most notably HRT use), indicating the potential for estimates to be confounded by underlying risk differences, (5) mammography screening is likely to result in a modest level of over-diagnosis (8% for IBC and 12-14% for all BC among women eligible to participate in screening). Estimates were lower after adjustment for confounding. These results are comparable with findings from long-term follow-up of screening trials and with several recent cohort studies of European screening programs, but are lower than many other estimates.
Thesis (Ph.D.) -- University of Adelaide, School of Population Health, 2014
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Coyne, Jennifer Tressa. "Mammography screening : the role of the fear appeals and message framing, and the application of the health belief model and the extended parallel process model." Thesis, 2011. http://hdl.handle.net/1885/149749.

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Breast cancer is a prominent and severe disease affecting Australian women and a decrease in breast cancer mortality rates has been attributed to mammography screening. Phase one of this study tests the application of the Health Belief Model (HBM) with mammography screening behaviour, and further tests the value of an extended HBM involving three additional variables. Phase two of this study tests the Framing Postulate of Prospect Theory and attempts to explain results by using the Extended Parallel Process Model (EPPM) and the HBM. Participants included 269 women aged 50 to 69 years and included women who do, and women who do not, obtain regular mammograms. Participation involved completing an initial survey before reading one of three framed messages randomly assigned, and completing a subsequent survey. Survey items were based on the HBM and the EPPM. Results showed that the basic 4-factor HBM was significantly associated with screening behaviour - despite only one core HBM factor, perceived barriers, having an association on its own. The extended 7-factor HBM was found to be significantly more associated with screening behaviour than the 4-factor HBM. Results of the present study provide support for the use of fear appeals but indicate the HBM does not adequately account for the perceived benefits of the appeals. Results further showed the EPPM accounted for pre-existing screening behaviour, but not for the effects of the fear appeal. Results suggest further clarification is required as to the effects and explanations of fear appeals and message framing in applied settings related to mammography screening.
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Farshid, Gelareh. "Contributions to the early diagnosis and modern management of breast cancer." 2010. http://hdl.handle.net/2440/59203.

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Title page, table of contents and summary only. The complete thesis in print form is available from the University of Adelaide Library.
I hereby submit a body of original research for consideration of the award of Doctor of Medicine from the University of Adelaide. This is a collection of published original research that has made substantial contributions to the modern diagnosis and management of breast cancer. The publications have been presented in three clusters, each of which represents one facet of the modern approach to the diagnosis and management of breast cancer. The first section presents my publications on the theme of population based mammographic screening for the early detection of breast cancer. Broadly, the research focus in these publications is on the evaluation of existing methods of assessment of screen-detected breast lesions in order to improve diagnostic accuracy and limit the morbidity associated with mammographic screening. The clinical value of these contributions has been demonstrated independently since this body of work has informed many of the algorithms and protocols used by the South Australian breast cancer screening program. In addition, the protocols have been adopted for use outside of the screening setting into the wider diagnostic arena. The clinical endorsement of my research contributions is a significant acknowledgement of their practical value. The middle group of publications describe my contributions towards the evolving role of sentinel node biopsy as an alternative to axillary clearance for the staging of breast cancer. This area is of particular cogent to our setting, since a large proportion of screen-detected breast cancers, approximately 80%, are node negative. Thus, avoidance of the morbidity of axillary clearance while still achieving accurate axillary staging is of enormous appeal to our patients. My pioneering work in devising and evaluating protocols for the pathologic examination of sentinel nodes has informed the recommendations of the NHMRC sponsored SNAC (Sentinel Node versus Axillary Clearance) randomised trial. Consequently, these protocols have been used extensively and even outside of the trial setting, most pathology laboratories utilise similar assessment protocols as was recommended in SNAC. Furthermore, the United Kingdom's recommendations for the pathology examination of sentinel nodes have drawn on our research. After validating the concept of SNs in breast cancer, many of the clinically important questions emerging in this field have been addressed by our team. For example, my work on intra-operative imprint cytology was a conclusive demonstration of the value and limitations of this technique for one stage axillary surgery. In the light of our findings intra-operative assessment of sentinel nodes has been expanded to many centres and is endorsed by the SNAC trial. In the third section of this thesis, my contributions to the rapidly evolving field of molecular and genetics of breast cancer are highlighted . Through the Australian HER2 Advisory Board, we have led the evaluation and roll out of alternative platforms for HER2 testing and in developing algorithms for the efficient use of resources. We have devised national testing algorithms in both settings of metastatic and early breast cancer. These algorithms have since been utilised by the international HER2 testing bodies. In a further bold initiative, our group pioneered the move to the national adoption of bright field In situ hybridization as the first line testing platform for all newly diagnosed breast cancers throughout Australia. This ambitious undertaking entailed design and implementation of a nation-wide program of training, certification, quality assurance and evaluation. It has been deployed successfully and under my leadership, our laboratory was one of only four laboratories in Australia to commence this test in October 2006. Similarly, in the area of the genetics of breast cancer, my interest in this field and membership of the pathology subcommittee of KCONFAB has provided opportunities to contribute to significant new knowledge that illustrate the role of pathology in identification of mutation associated breast cancers. Under my leadership, our multi-centre studies have provided cogent arguments in favour of the inclusion of the histopathologic and immunophenotypic characteristics of breast cancers in the triage of patients for genetic testing. These results were published in pre-eminent pathology journals and have been referred to at major scientific conferences. Plans are afoot for the future extensions of this work. I am committed to utilising my expertise for the provision of high quality diagnostic services as part of a multi-disciplinary team involved in the treatment of women with breast diseases. I believe an evidence-based approach is central to achieving continuous improvements in these efforts. I am persuaded that there is substantial evidence demonstrating the value of population based mammographic screening in interrupting the natural history of breast cancer and reducing mortality from this disease. I am grateful to have the opportunity to contribute to the provision of this care.
http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1473394
Thesis (M.D.) -- University of Adelaide, School of Medical Sciences, 2010
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Cheok, Frida. "Participation in mammographic screenings in South Australia / Frida Cheok." Thesis, 1998. http://hdl.handle.net/2440/19292.

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Includes bibliographical references (18 leaves).
2 v. : ill., maps ; 30 cm.
Examines the factors that predict attendence to mammography screening by comparing various groups of attenders and non-attenders.
Thesis (Ph.D.) -- University of Adelaide, Dept. of Public Health, 1999
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Pecháčková, Tereza. "Činnost nestátních neziskových organizací v oblasti péče o pacientky s rakovinou prsu." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-313533.

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This dissertation is focused on medical care field, introduces common issues of oncology illnesses. Presents the system and particularity of women's breast cancer care and looks into patient's rights and importace of foreknowledge. Also presents activities of non-state nonprofit organization focused on this sphere. The aim of this dissertation is to map involved organizations and analysis of their work. Investigates foreknowledge of patients about knowing of them and also finds topics of their intersect. Key words oncology diagnosis, breast cancer, patients organizations, prevention, second opinion, health service, non-profit non-govermental organizations, information asymmetry, mammography screening, informační asymetrie, mamografický screening
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Clarke, Philip M. "Valuing the benefits of health care in monetary terms with particular reference to mammographic screening." Phd thesis, 1997. http://hdl.handle.net/1885/144282.

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Books on the topic "Breast cancer; mammography screening; over-diagnosis"

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Mammography screening: Truth, lies and controversy. London: Radcliffe Pub, 2012.

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Shetty, Mahesh K. Breast cancer screening and diagnosis: A synopsis. New York: Springer, 2015.

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Rajendra, Acharya U., ed. Performance evaluation of breast cancer: Screening, diagnosis, and treatment. Stevenson Ranch, Calif: American Scientific Publishers, 2010.

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Western Australia. Working Party on Screening Mammography. Report to the Minister for Health for Western Australia from the Working Party on Screening Mammography. Perth: Health Dept. of Western Australia, 1987.

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Iron, Karey. A review of mammography utilization in Ontario. North York, Ont: Institute for Clinical Evaluative Sciences in Ontario, 1995.

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N, Perry, Puthaar E, and European Commission. Directorate-General for Health and Consumer Protection, eds. European guidelines for quality assurance in breast cancer screening and diagnosis. 4th ed. Luxembourg: Office for Official Publications of the European Communities, 2006.

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Peart, O. J. Lange Q & ATM Mammography Examination. New York: McGraw-Hill, 2008.

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Young, Deidra J. A report on women attending the Screening Mammography Pilot Programme in Western Australia: A compilation of eight client satisfaction surveys undertaken in Western Australia between May,1989 and May,1990. Subiaco, W.A: Women's Cancer Prevention Unit, Disease Control Branch, Health Dept. of Western Australia, 1991.

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Roger, Herdman, Norton Larry, and National Cancer Policy Board (U.S.). Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer., eds. Saving women's lives: Strategies for improving breast cancer detection and diagnosis. Washington, DC: National Academies Press, 2005.

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Office, General Accounting. Mammography services: Initial impact of new federal law has been positive : report to congressional committees. Washington, D.C: The Office, 1995.

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Book chapters on the topic "Breast cancer; mammography screening; over-diagnosis"

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Svahn, Tony Martin. "Digital Mammography and Digital Breast Tomosynthesis." In Breast Cancer Screening and Diagnosis, 65–91. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1267-4_4.

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Ortiz-Perez, Tamara, and Alfred B. Watson. "Mammography Techniques, Positioning, and Optimizing Image Quality." In Breast Cancer Screening and Diagnosis, 37–63. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1267-4_3.

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Tabár, László, Peter B. Dean, Tony Hsiu-Hsi Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Tibor Tot, Robert A. Smith, and Stephen W. Duffy. "The Impact of Mammography Screening on the Diagnosis and Management of Early-Phase Breast Cancer." In Breast Cancer, 31–78. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8063-1_2.

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van Engen, Ruben E., Kenneth C. Young, Hilde Bosmans, Barbara Lazzari, Stephan Schopphoven, Patrice Heid, and Martin Thijssen. "A supplement to the European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis." In Digital Mammography, 643–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13666-5_87.

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Shetty, Mahesh K. "Mammographic Signs of Breast Cancer." In Breast Cancer Screening and Diagnosis, 93–117. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1267-4_5.

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Shetty, Mahesh K. "Optimizing Mammographic Screening and Diagnosis of Breast Cancer." In Breast Cancer Screening and Diagnosis, 201–12. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1267-4_10.

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Saeed, Soobia, Noor Zaman Jhanjhi, Mehmood Naqvi, Mamoona Humyun, Muneer Ahmad, and Loveleen Gaur. "Optimized Breast Cancer Premature Detection Method With Computational Segmentation." In Approaches and Applications of Deep Learning in Virtual Medical Care, 24–51. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8929-8.ch002.

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Breast cancer is the most common cancer in women aged 59 to 69 years old. Studies have shown that early detection and treatment of breast cancer increases the chances of survival significantly. They also demonstrated that detecting small lesions early improves forecasting and results in a significant reduction in death cases. The most effective screening diagnostic technique in this case is mammography. However, interpretation of mammograms is difficult due to small differences in tissue densities within mammographic images. This is especially true for dense breasts, and this study suggests that screening mammography is more effective in fatty breast tissue than in dense breast tissue. This study focuses on breast cancer diagnosis as well as identifying risk factors and their assessments of breast cancer as well as premature detection of breast cancer by analyzing 3D MRI mammography methods and segmentation of mammographic images using machine learning.
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Baâzaoui, Abir, and Walid Barhoumi. "Breast Cancer Diagnosis With Mammography." In Research Anthology on Medical Informatics in Breast and Cervical Cancer, 701–21. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-7136-4.ch037.

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Breast cancer, which is the second-most common and leading cause of cancer death among women, has witnessed growing interest in the two last decades. Fortunately, its early detection is the most effective way to detect and diagnose breast cancer. Although mammography is the gold standard for screening, its difficult interpretation leads to an increase in missed cancers and misinterpreted non-cancerous lesion rates. Therefore, computer-aided diagnosis (CAD) systems can be a great helpful tool for assisting radiologists in mammogram interpretation. Nonetheless, these systems are limited by their black-box outputs, which decreases the radiologists' confidence. To circumvent this limit, content-based mammogram retrieval (CBMR) is used as an alternative to traditional CAD systems. Herein, authors systematically review the state-of-the-art on mammography-based breast cancer CAD methods, while focusing on recent advances in CBMR methods. In order to have a complete review, mammography imaging principles and its correlation with breast anatomy are also discussed.
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Baâzaoui, Abir, and Walid Barhoumi. "Breast Cancer Diagnosis With Mammography." In Biomedical Computing for Breast Cancer Detection and Diagnosis, 107–27. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-3456-4.ch006.

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Breast cancer, which is the second-most common and leading cause of cancer death among women, has witnessed growing interest in the two last decades. Fortunately, its early detection is the most effective way to detect and diagnose breast cancer. Although mammography is the gold standard for screening, its difficult interpretation leads to an increase in missed cancers and misinterpreted non-cancerous lesion rates. Therefore, computer-aided diagnosis (CAD) systems can be a great helpful tool for assisting radiologists in mammogram interpretation. Nonetheless, these systems are limited by their black-box outputs, which decreases the radiologists' confidence. To circumvent this limit, content-based mammogram retrieval (CBMR) is used as an alternative to traditional CAD systems. Herein, authors systematically review the state-of-the-art on mammography-based breast cancer CAD methods, while focusing on recent advances in CBMR methods. In order to have a complete review, mammography imaging principles and its correlation with breast anatomy are also discussed.
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Anbarasan, Kalaivani, and Ramya S. "A Survey on Female Breast Cancer." In Medical Image Processing for Improved Clinical Diagnosis, 209–26. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-5876-7.ch010.

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The mortality rate of breast cancer can be effectively reduced by early diagnosis. Imaging modalities are used to diagnose through computer for women breast cancer. Digital mammography is the best imaging model for breast cancer screening technique and diagnosis. Digital breast tomosynthesis (DBT), a three-dimensional (3-D) mammography, is an advanced form of breast imaging where multiple images of the breast from different angles are captured and reconstructed (synthesized) into a three-dimensional image set. This chapter discusses the research work carried out on the computer diagnosis of women breast cancer through digital breast tomosynthesis and concludes with further improvement in the computer-aided diagnosis.
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Conference papers on the topic "Breast cancer; mammography screening; over-diagnosis"

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Moreno, Andre, Kimberly Masiero Cola, Larissa Heberle, and Marcelo Moreno. "RELATIONSHIP BETWEEN IMMUNOHISTOCHEMICAL CHARACTERIZATION AND FORM OF DIAGNOSIS OF BREAST CANCER." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1008.

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Introduction: Breast cancer is the most incident neoplasia among Brazilian women. According to immunogenetic characteristics, it is possible to verify that malignant breast neoplasms with greater biological activity would be those classified as luminary B, HER2+ and triple-negative, and that the one with the lowest biological activity would be the luminal subtype A. Thus, a mammography would be more likely to detect cancers with a low degree of biological characteristics such as “luminal A”. On the other hand, mammary carcinomas with greater potential for systemic dissemination show faster growth in the breast parenchyma and are detected predominantly by self-examination. Knowledge of this difference in the clinical behavior of mammary malignant neoplasms is important for the diagnosis of “interval” breast cancers, that is, breast cancer that appears in the period between the performance of annual screening mammograms. Objectives: Verify the relationship between immunohistochemical characterization of malignant breast neoplasms and the finding that motivated the medical consultation, in women with breast cancer and residents of Western Santa Catarina, Brazil. Methods: Observational, cross-sectional study, which included women diagnosed with breast cancer and treated at an oncology referral center in the city of Chapecó, state of Santa Catarina, Brazil, from January 2000 to December 2016. Patients that presented medical records whose main complaint was towards the diagnosis of breast cancer were included (example: nodule diagnosed by imaging exams, self-examination, clinical examination). Besides this, the breast injury related to this complaint should have been breast cancer diagnosed by an anatomopathological examination and an immunohistochemistry study. The project was developed in accordance to CEP/UNOCHAPECO no. 1819869. Results: Data from 209 patients were analyzed, from which 83 (39.7%) cases of breast cancer were detected by a mammography examination; 115 (55%) cases by breast self-examination and 11 (5.2%) cases by other forms of examination, which included clinical breast examination done by a doctor, magnetic resonance imaging and ultrasound. The luminal A immunohistochemical profile was more prevalent among patients who underwent breast cancer detection through mammography (62.6%). There was a correlation between lymph node invasion and the screening method, in which 78.6% of cancers detected by self-examination showed expansion to lymph nodes, while those detected by mammography presented an invasion rate of 45.7% (p=0.002). Conclusions: Breast cancer with immunohistochemical characterization, related to greater biological activity, were most often detected by self-examination, while neoplasms with indolent development were diagnosed predominantly by mammography.
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Silva, Antonio Márcio Teodoro Cordeiro, Liliane Emilly dos Santos Sousa, Camila de Assunção Martins, Bárbara de Magalhães Souza Gomes, Jacqueline Andréia Bernardes Leão Cordeiro, Fábio Silvestre Ataides, and Cesar Augusto Sam Tiago Vilanova Costa. "EARLY TRACKING THROUGH MAMMOGRAPHY IN BREAST CANCER DETECTION IN WOMEN IN BRAZIL FROM 2015 TO 2019: EPIDEMIOLOGICAL STUDY." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2113.

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Objectives: To analyze the aspects of mammography in the early screening of breast cancer, in Brazil, from 2015 to 2019. Methodology: Descriptive epidemiological study, with secondary data extracted from the Department of Informatics of the Brazilian Unified Health System (DATASUS), through the Cancer Information System (SISCAN). Information related to mammography examinations was classified by place of care according to the clinical indication (screening or diagnosis), age group (70 years), previous mammography, high risk of breast cancer (BC), examination completion time, and the Breast Imaging Reporting and Data System (BI-RADS®), which classifies radiological findings as 0 (undefined), 1 (negative), 2 (benign), 3 (probably benign), 4 (suspect), 5 (highly suspicious), and 6 (diagnosed with cancer). Results: Between 2015 and 2019, 3,031,607 mammograms were performed in Brazil, of which 2,955,262 occurred by screening and 76,345 by clinical diagnostic indication. Among the screening mammograms, 63.2% were performed on women in the age group recommended by the Brazilian Ministry of Health (MS), from 50 to 69 years old. The previous history of this examination was confirmed by 2,300,995 women, where 17.5% were at high risk for BC. For the examination time, 1,396,105 mammograms took place within 30 days, and 775,971 and 859,531 over 60 days. BI-RADS was higher in category 2 (1,520,469 mammograms), followed by category 1 with 1,071,514 of mammograms, and in the target population recommended by the Brazilian Ministry of Health, the largest number of tests was concentrated in BI-RADS category 2 with 34.2%. Conclusion: Characterization of the main aspects involved in mammography, such as age, high risk, and among others, allows to infer that the early screening of BC when prioritized by public health policies, aiming at the promotion of women’s health, impacts on the early detection and the reduction of the incidence and mortality by BC in women in Brazil.
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Vivian, Fernando, Daniela Boeira, Bruna Kikuchi Sacchielle, Gabriela Grechi Carrard, and Luiza Herdy Boechat Luz Tiago. "ANALYSIS OF THE EFFECTIVENESS OF MAMMOGRAPHIC SCREENING IN A PINK OCTOBER CAMPAING." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1013.

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Introduction: The month of October was chosen to raise the population’s awareness of breast cancer, with strategic actions being taken in order to optimize an early diagnosis of malignant breast lesions, as well as their treatment. The city of Caxias do Sul annually promotes a health action on a Saturday in October, known as the Pink October Campaign. The analyzed campaign was on the first Saturday of October 2017, with the operation of all Basic Health Units (UBS), and according to recommendations from the Brazilian Society of Mastology, offering mammographic evaluation and screening for women over 40 years of age. Objectives: To identify the number of diagnoses of malignant neoplasms in women who underwent screening mammography in a municipal campaign, the number of examinations performed in the campaign, and the prevalence of the BI-RADS 4 and BI-RADS 5 categories. Methods: Observational, descriptive, and retrospective study. All patients who had mammograms requested in the Pink October campaign were identified. The BI-RADS 4 and 5 cases on mammography, or after the completion of a complementary ultrasound for presenting BI-RADS 0 on the initial mammography, were referred to a reference service and had a biopsy with a posterior segment. Results: 1220 mammograms were made. In the BI-RADS 4 category, nine patients were identified (0.73%); all had biopsies performed, and three patients had confirmed carcinoma: two of them with invasive carcinoma and one case with carcinoma in situ. There were two cases of BI-RADS 5 mammograms (0.16%), and both had pathological confirmation of malignancy through biopsy. The prevalence of BI-RADS 4 and 5 in this population was 0.73% and 0.16%, respectively. There were 126 BI-RADS 0 mammograms (10.33%), making it possible to perform 90 complementary breast ultrasound exams. Four cases were classified as BI-RADS 4, with a negative biopsy for malignancy, and one case of BI-RADS 5, with a diagnosis of invasive lobular carcinoma. Conclusions: The Pink October Campaign held in 2017 in Caxias do Sul provided the diagnosis of six cases of breast malignancy in women between 43 and 65 years of age, one of them still in the non-invasive stage (carcinoma in situ), representing 0.49% of the population tracked in the campaign.
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Ramos, Marcellus Nascimento Moreira, Andressa Gonçalves Amorim, Andre Mattar, Luis Henrique Gebrim, and Mariana Dinau Leal Passos. "CLINICAL, IMAGING AND THERAPEUTIC CHARACTERISTICS OF 332 PATIENTS WITH DUCTAL CARCINOMA IN SITU (DCIS): A SINGLE‑ CENTER ANALYSIS." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1063.

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Introduction: Organized mammographic screening led to an increase in the diagnosis of DCIS. In countries with adequate mammographic coverage, the percentage of DCIS reaches 20%. In Brazi, most of the states only perform occasional mammographic screening, and data about DCIS incidence is scarce. Objectives: Analyze and describe clinical, diagnostic, imaging and therapeutic characteristics of patients diagnosed with DCIS and treated at Pérola Byington Hospital (PBH), Brazil. Methods: The official database of PBH from January 2011 to December 2019 showed 11,373 cases of breast cancer, and 812 (7.4%) of them were DCIS. We analyzed retrospectively the medical record of 332 patients who underwent biopsy, vaccum assisted biopsy guided by mammography or ultrasound whose diagnosis was DCIS, and they were treated at the hospital. Patients with previous breast cancer or lobular neoplasia were excluded. We divided the analysis into two groups, based on the type of surgery they underwent, conservative or radical surgery. Some patients have been submitted to the sentinel lymph node biopsy (SLNB) at surgery and the blue technique stained by H&E (hematoxylin and eosin) was used. Results: Most patients underwent conservative surgical treatment (73.5%), with a SLNB in 34.5%. Mastectomy was performed in 26.5% of cases and in this group 93.2% there was also axillary surgery. None of the sentinel nodes was involved. In the conservative surgery group, the mammographic alterations were the main cause for the diagnosis in 80.3% of the cases, with calcifications being the most common alteration in 73.9% of the cases, followed by the palpable lesion in 18.5% of them. Mammography was also the main diagnostic test in the group of patients who underwent mastectomy (73.9%) and calcifications appeared in 67% of cases, followed by palpable lesions in 28.1%. When assessing local recurrence, a percentage of 6.4% was found in conservative surgery (ten in situ and five invasive) and 4.5% in mastectomy (one in situ and four invasive). Conclusions: The 7.4% incidence of DCIS shows that even though lower than in countries that have organized screening, it is a growing demand, especially for the public health system where stereotactic biopsy is not available in many centers. Despite the fact that most of the cases were non palpable, we found that mastectomy was indicated in 23.5% of them, probably because of the extension and multicentricity of the DCIS. The absence of metastases in SNB made us rethink the real need for its indication.
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Negrão, Erika Marina Solla, Livia Conz, Silvia Maria Prioli de Souza Sabino, Anapaula Hidemi Uema Watanabe, Jane Camargo da Silva Santos Picone, and Edmundo Carvalho Mauad. "GRANULAR CELL TUMOR SIMULATING BREAST CANCER ON SCREENING MAMMOGRAM: CASE REPORT." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2115.

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Introduction: Granular cell tumor involving the breast parenchyma is very rare, representing between 5 and 15% of the presentations of this tumor. Due to the appearance of the image, it is confused with breast carcinoma; therefore, it can be a diagnostic challenge for medical mastologists, radiologists, and pathologists. Presentation of the case: We report the case of a 45-year-old woman who presented a lesion identified by ultrasound image with characteristics classified as highly suspected of malignancy (BIRADS 4c). The screening mammography detected a dense image of obscured margins, and the ultrasonography revealed a homogeneous irregular nodule with indistinct margins, located in the upper lateral quadrant of the right, posterior, and peripheral breast measuring 1.2 cm. The lesion was subjected to percutaneous biopsy, and the histological examination combined with an immunohistochemical study revealed that it was a granular cell tumor. Conclusion: Although the granular cell tumor of the breast is a rare breast cancer, it must be considered in the differential diagnosis of lesions detected in imaging examinations. The granular cell tumor of the breast is a benign lesion, but the radiological findings suggest a malignant tumor, clinically and radiographically impossible to establish a definitive diagnosis without a biopsy.
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Veloso, Priscilla Maquinêz, Jorge Yoshinori Shida, Luiz Henrique Gebrim, and André Mattar. "EVALUATION OF AGE GROUP OF 11,323 BREAST CANCER PATIENTS TREATED FROM JANUARY 2011 TO DECEMBER 2019 AT PEROLA BYINGTON HOSPITAL." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1024.

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Introduction: According to estimates from the Brazilian Department of Health, in 2021 we will see more than 65,000 cases of breast cancer in Brazil. The predominance of advanced cases in the Brazilian Unified Health System (SUS) stems from the long time for diagnosis and treatment of patients and, consequently, leads to a higher mortality rate. There is a lack of data on the age of our patients to establish an adequate coping strategy for the disease and thus reduce mortality in our country. The Department of Health recommends mammography from the age of 50. The Brazilian Society of Mastology (SBM), on the other hand, recommends exams starting at 40. Before that, only for groups at risk. In 2018, there were 2,1 million new cases, equivalent to 11.6% of all estimated cancers. This value corresponds to an estimated risk of 55.2/100 thousand. The highest expected incidence rates were in Australia and New Zealand, in Northern European countries and in Western Europe. Regardless of the country’s socioeconomic situation, the incidence of this cancer ranks among the top positions for female malignancies. On the other hand, there has been a decline in the trend of incidence rates in some developed countries, partly linked to the decrease in hormone replacement therapy in postmenopausal women. Objectives: This paper aims to describe treatment of breast cancer according the age group of 11,323 women by SUS at Pérola Byington Hospital from January 2011 to December 2019. Methods: A hospital-based observational crosssectional study was carried out, in which the eligible population consisted of 11,323 patients with breast cancer treated by SUS at Pérola Byington Hospital whose data was registered in the data collection system of that hospital. Women under the age of 20 years up to over 80 years were selected. Results: A predominance of the diagnosis was observed in women aged 50 to 59 years (27.91%), followed by patients aged 40 to 49 years (23.90%) and by patients aged 60 to 69 years (22.26%). Women under the age of 20 were diagnosed in 0.06% of cases and over 80 years of age in 4.75%. Conclusions: The diagnosis of breast cancer in women under 40 years of age is rare, representing around 10% of all registered cases. But, when it occurs in this age group, the disease tends to be more aggressive, raising a question of from what age the screening test should be performed.
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Cate, SP, MK Kohli, A. Gillego, M. Chadha, T. Fulop, and SK Boolbol. "Abstract P6-02-01: Screening mammography in women over age 75: Is it beneficial?" In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-p6-02-01.

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Ramos, Dandara Rocha, Maria Fernanda Passos Rocha Ramos, Paulus Fabricio Mascarenhas Ramos, and Katia de Miranda Avena. "DIAGNOSIS OF BREAST CANCER IN BRAZIL: REFLECTION ON THE IMPACT OF THE COVID-19 PANDEMIC." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2005.

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Objective: To compare the number of breast cancer diagnoses performed in the public health system in Brazil, in the period from 2015 to 2020, analyzing the effects of the coronavirus disease 2019 (COVID-19) pandemic. Methodology: This is an observational, cross-sectional study, with a descriptive and quantitative approach, which is carried out with secondary data provided by the Cancer Information System (SISCAN/DATASUS), considering two time frames — before the pandemic (2015–2019) and during the pandemic (2020). The study included women diagnosed with breast cancer, who underwent mammography between 2015 and 2020. Appreciation by the Research Ethics Committee was waived because public, aggregated data were used, without identifying the participants. Results: Between 2015 and 2020, 14,598,318 mammograms were performed in Brazil. The temporal analysis shows a gradual upward behavior in all years, reaching a growth of 49.6% from 2015 (n=2,047,295) to 2019 (n=3,063,022). In the year 2020, there is a significant drop (39.8%) in the number of mammograms performed (n=1,843,182). From 2015 to 2020, 197,368 breast cancer diagnoses were carried out in Brazil. As with the monographs, in the year of the pandemic, a significant drop (46.9%) was demonstrated in the diagnoses performed (n=22,167), a figure that represents only 33.4% of the estimate for 2020 made by the National Cancer Institute (n=66,280). Conclusions: With the emergence of the COVID-19 pandemic and the magnitude taken by it, there was a significant impact on the screening, monitoring, and treatment of breast cancer in the country. It is possible that measures of social isolation to contain the virus contributed to this behavior, causing underdiagnosis and future expectations of less favorable prognosis. It is believed that this scenario will worsen in 2021 in view of the number of cases that are no longer diagnosed, a fact that possibly will reflect on the severity of the cases and the costs for public health.
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Mendez, Marissa A., An-Lin Cheng, and Nasim Ahmadiyeh. "Abstract P2-02-02: Lack of screening mammography and black race are associated with late-stage breast cancer diagnosis in safety-net setting." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p2-02-02.

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Ragaz, Joseph, Hubert Wong, Hong Qian, Joel Fox, Kenneth Wilson, and Andrew Coldman. "Abstract P3-07-28: Population-based rates of in-situ breast cancer [DCIS] invasive breast cancer [BrINV], and breast cancer [BrCa] mortality [BrMOR] over time. A case for screening mammography? [ScreenMam]." In Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-p3-07-28.

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Reports on the topic "Breast cancer; mammography screening; over-diagnosis"

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Yelena, Gorina, and Elgaddal Nazik. Patterns of Mammography, Pap Smear, and Colorectal Cancer Screening Services Among Women Aged 45 and Over. National Center for Health Statistics, June 2021. http://dx.doi.org/10.15620/cdc:105533.

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This study examines and compares sociodemographic, health status, and health behavior patterns of screening for breast cancer, cervical cancer, and colorectal cancer among women aged 45 and over in the United States.
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Zhang, Yuan, and RuiBin Feng. Breast specific gamma imaging versus ultrasound and mammography for breast cancer screening and diagnosis: A meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0148.

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