Relevant bibliographies by topics / Brd7

Academic literature on the topic 'Brd7'

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Published: 11 March 2023

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Journal articles on the topic "Brd7"

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Hay, Duncan A., Catherine M. Rogers, Oleg Fedorov, Cynthia Tallant, Sarah Martin, Octovia P. Monteiro, Susanne Müller, Stefan Knapp, Christopher J. Schofield, and Paul E. Brennan. "Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains." MedChemComm 6, no. 7 (2015): 1381–86. http://dx.doi.org/10.1039/c5md00152h.

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Ali, Maria Mushtaq, Sajda Ashraf, Mohammad Nure-e-Alam, Urooj Qureshi, Khalid Mohammed Khan, and Zaheer Ul-Haq. "Identification of Selective BRD9 Inhibitor via Integrated Computational Approach." International Journal of Molecular Sciences 23, no. 21 (November 4, 2022): 13513. http://dx.doi.org/10.3390/ijms232113513.

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Bromodomain-containing protein 9 (BRD9), a member of the bromodomain and extra terminal domain (BET) protein family, works as an epigenetic reader. BRD9 has been considered an essential drug target for cancer, inflammatory diseases, and metabolic disorders. Due to its high similarity among other isoforms, no effective treatment of BRD9-associated disorders is available. For the first time, we performed a detailed comparative analysis among BRD9, BRD7, and BRD4. The results indicate that residues His42, Gly43, Ala46, Ala54, Val105, and Leu109 can confer the BRD9 isoform selectivity. The predicted crucial residues were further studied. The pharmacophore model’s features were precisely mapped with some key residues including, Gly43, Phe44, Phe45, Asn100, and Tyr106, all of which play a crucial role in BRD9 inhibition. Docking-based virtual screening was utilized with the consideration of the conserved water network in the binding cavity to identify the potential inhibitors of BRD9. In this workflow, 714 compounds were shortlisted. To attain selectivity, 109 compounds were re-docked to BRD7 for negative selection. Finally, four compounds were selected for molecular dynamics studies. Our studies pave the way for the identification of new compounds and their role in causing noticeable, functional differences in isoforms and between orthologues.
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Shi, Mingsong, Jun He, Tiantian Weng, Na Shi, Wenyan Qi, Yong Guo, Tao Chen, Lijuan Chen, and Dingguo Xu. "The binding mechanism of NHWD-870 to bromodomain-containing protein 4 based on molecular dynamics simulations and free energy calculation." Physical Chemistry Chemical Physics 24, no. 8 (2022): 5125–37. http://dx.doi.org/10.1039/d1cp05490b.

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Lim, Ratana, Caitlyn Nguyen-Ngo, and Martha Lappas. "Targeting bromodomain-containing proteins to prevent spontaneous preterm birth." Clinical Science 133, no. 23 (December 2019): 2379–400. http://dx.doi.org/10.1042/cs20190919.

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Abstract Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are currently no effective therapies available. The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. The roles of Brd2–4 in human pregnancy are unknown. Using human and mouse models, the present study has identified the Brd proteins part of the process by which inflammation induces parturition. Using human clinical samples, we demonstrate that labor and infection increase the expression of Brds in the uterus and fetal membranes. In primary human myometrial, amnion and decidual cells, we found that global Brd protein inhibition, as well as selective inhibition of Brds, suppressed inflammation-induced expression of mediators involved in myometrial contractions and rupture of fetal membranes. Importantly, studies in the mouse model demonstrate that the pan-Brd inhibitor JQ1 reduced intrauterine inflammation induced by bacterial endotoxin LPS as well as decreasing the effectiveness of LPS to induce parturition. These results implicate BET proteins as novel therapeutic targets for reducing inflammation associated with spontaneous preterm labor.
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Kapoor, Sabeeta, and Roderick H. Dashwood. "Abstract 5712: Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5712. http://dx.doi.org/10.1158/1538-7445.am2022-5712.

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Abstract Introduction Epigenetic mechanisms play an important role in the initiation and advancement of colorectal cancer (CRC) and other malignancies due, in part, to deregulated bromodomain (BRD) functions1,2. We examined compounds from natural sources as BRD7/9 inhibitors, seeking lead candidates outside of the widely studied bromodomain and extraterminal (BET) family3. Methods As reported4,5, docking in silico involved STRAP and AutoDock Vina, ligand-protein interactions employed PDBePISA and LPC/CSU, and BROMOscan®-Bromodomain arrays were used to screen for BRD7/9 interacting compounds. BRD7/9 inhibitors also were assessed by isothermal titration calorimetry (ITC) and by anticancer activities in human colon cancer cells. Results Docking in silico identified several dietary polyphenols as potential BRD7/9 inhibitors, with binding energies ≤ -8.0 kcal/mol. BROMOscan® and ITC experiments prioritized aspalathin, orientin, epigallocatechin-3-gallate, quercetin and equol for further investigation. Treatment with selected polyphenols mimicked BRD7/9 siRNA-mediated knockdown in reducing colon cancer cell viability and inhibiting colony formation, leading to DNA damage and apoptosis induction. Normal colonic epithelial cells were unaffected by the treatments, signifying cancer-specific targeting. These findings suggest that dietary polyphenols can recognize and target BRD7/9 proteins for potential cancer interception. Acknowledgements Research supported in part by NCI grant CA122959, the John S. Dunn Foundation, and a Chancellor's Research Initiative.1)Jung G et al., Nat Rev Gastroenterol Hepatol 2020;17:111-130. 2)Fujisawa T, Filippakopoulos P. Nat Rev Mol Cell Biol 2017;18:246-262.3)Damiani E et al., J Cancer Prev 2020;25:189-203. 4)Rajendran P et al., Cancer Res 2019;79:918-927. 5)Kapoor S et al., Cancers (Basel) 2021;13:1438. Citation Format: Sabeeta Kapoor, Roderick H. Dashwood. Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5712.
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Lee, Junsik M., Renyan Liu, and Sang Won Park. "The regulatory subunits of PI3K, p85α and p85β, differentially affect BRD7-mediated regulation of insulin signaling." Journal of Molecular Cell Biology 13, no. 12 (November 9, 2021): 889–901. http://dx.doi.org/10.1093/jmcb/mjab073.

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Abstract Bromodomain-containing protein 7 (BRD7) has been shown to interact with the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), p85, in the insulin signaling pathway. Here, we show that upregulation of hepatic BRD7 improves glucose homeostasis even in the absence of either p85 isoform, p85α or p85β. However, BRD7 leads to differential activation of downstream effector proteins in the insulin signaling pathway depending on which isoform of p85 is present. In the presence of only p85α, BRD7 overexpression increases phosphorylation of insulin receptor (IR) upon insulin stimulation, without increasing the recruitment of p85 to IR substrate. Overexpression of BRD7 also increases activation of Akt in response to insulin, but does not affect basal phosphorylation levels of Akt. Meanwhile, the phosphorylation of glycogen synthase kinase 3β (GSK3β) is increased by overexpression of BRD7. On the other hand, in the presence of only p85β, BRD7 overexpression does not affect phosphorylation levels of IR, and Akt phosphorylation is not affected by insulin stimulation following BRD7 upregulation. However, BRD7 overexpression leads to increased basal phosphorylation levels of Akt and GSK3β. These data demonstrate that BRD7’s action on glucose homeostasis does not require the presence of both p85 isoforms, and p85α and p85β have unique roles in insulin signaling in the liver.
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Clark, Peter G. K., Darren J. Dixon, and Paul E. Brennan. "Development of chemical probes for the bromodomains of BRD7 and BRD9." Drug Discovery Today: Technologies 19 (March 2016): 73–80. http://dx.doi.org/10.1016/j.ddtec.2016.05.002.

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Park, Sang Won, and Junsik M. Lee. "Emerging Roles of BRD7 in Pathophysiology." International Journal of Molecular Sciences 21, no. 19 (September 27, 2020): 7127. http://dx.doi.org/10.3390/ijms21197127.

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Bromodomain is a conserved structural module found in many chromatin-associated proteins. Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain-containing protein family, and was discovered two decades ago as a protein that is downregulated in nasopharyngeal carcinoma. Since then, BRD7 has been implicated in a variety of cellular processes, including chromatin remodeling, transcriptional regulation, and cell cycle progression. Decreased BRD7 activity underlies the pathophysiological properties of various diseases in different organs. BRD7 plays an important role in the pathogenesis of many cancers and, more recently, its roles in the regulation of metabolism and obesity have also been highlighted. Here, we review the involvement of BRD7 in a variety of pathophysiological conditions, with a focus on glucose homeostasis, obesity, and cancer.
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Crodian, Jennifer S., Bethany M. Weldon, Yu-Chun Tseng, Birgit Cabot, and Ryan Cabot. "Nuclear trafficking dynamics of Bromodomain-containing protein 7 (BRD7), a switch/sucrose non-fermentable (SWI/SNF) chromatin remodelling complex subunit, in porcine oocytes and cleavage-stage embryos." Reproduction, Fertility and Development 31, no. 9 (2019): 1497. http://dx.doi.org/10.1071/rd19030.

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In the work presented here, we investigated how bromodomain-containing protein 7 (BRD7), a subunit associated with switch/sucrose non-fermentable (SWI/SNF) chromatin remodelling complexes, is trafficked between cellular compartments during embryo development. SWI/SNF complexes are multi-subunit complexes that contain a core catalytic subunit (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4, or member 2; SMARCA4 or SMARCA2) and a collection of additional subunits that guide the complexes to their appropriate loci; BRD7 is one of these additional subunits. We hypothesised that BRD7 is exported from the nuclei of porcine oocytes and embryos in a Chromosome Region Maintenance 1 (CRM1)-dependent manner and imported into the nuclei using the karyopherin α/β1 heterodimer. Porcine oocytes and embryos were treated with inhibitors of CRM1-mediated nuclear export and karyopherin α/β1-mediated nuclear import to test this hypothesis. An RNA interference assay and a dominant negative overexpression assay were also performed to determine if karyopherin α7 serves a specific role in BRD7 trafficking. Our findings indicate that BRD7 shuttles between nuclear and cytoplasmic compartments during cleavage development. The shuttling of BRD7 indicates that it serves a unique role in remodelling chromatin during this developmental window.
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KZHYSHKOWSKA, Julia, Andre RUSCH, Hans WOLF, and Thomas DOBNER. "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7." Biochemical Journal 371, no. 2 (April 15, 2003): 385–93. http://dx.doi.org/10.1042/bj20021281.

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E1B-AP5 was initially identified as a target of the early adenovirus E1B-55kDa protein during the course of lytic infection. E1B-AP5 belongs to the heterogeneous nuclear ribonucleoprotein family and was demonstrated to be involved in mRNA processing and transport [Gabler, Schutt, Groitl, Wolf, Shenk and Dobner (1998) J. Virol. 72, 7960–7971]. In the present paper, we demonstrate that E1B-AP5 differentially regulates basic and ligand-dependent transcription. We found that E1B-AP5 represses basic transcription driven by several virus and cellular promoters, and mapped the repression activity to the N-terminal part of the protein. In contrast with basic repression, E1B-AP5 activated the glucocorticoid-dependent promoter in the absence of dexamethasone, but did not contribute to the dexamethasone-induced activation. Mutant analysis indicated the presence of an additional cellular factor that modulates E1B-AP5 transcriptional activity. Using yeast two-hybrid screening, we identified a novel chromatin-associated bromodomain-containing protein, BRD7, as an E1B-AP5 interaction partner. We confirmed E1B-AP5–BRD7 complex formation in vivo and in vitro. We found that, although BRD7 binds to histones H2A, H2B, H3 and H4 through its bromodomain, this domain was not necessary for the interaction with E1B-AP5. Indeed, the triple complex formation of E1B-AP5, BRD7 and histones was demonstrated. Disruption of the E1B-AP5–BRD7 complex increased E1B-AP5 repression activity for basic transcription and converted it from being an activator of the hormone-dependent promoter into being a strong repressor. We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation.
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Dissertations / Theses on the topic "Brd7"

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Tocco, Francesca. "Modulation of p53 activities by the prolyl-isomerase PIN1 and the bromodomain protein BRD7." Doctoral thesis, Università degli studi di Trieste, 2008. http://hdl.handle.net/10077/2622.

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2006/2007
ABSTRACT: MODULATION OF p53 ACTIVITIES BY THE PROLYL-ISOMERASE PIN1 AND THE BROMODOMAIN PROTEIN BRD7 The tumour suppressor p53 belongs to a family of transcription factors that play key roles in maintaining genomic stability and cellular homeostasis. The orchestration of the appropriate cellular responses depends on the fine regulation of p53’s functions through post-translational modifications and interaction with other proteins. In many years of intense study a considerable knowledge on p53 activity has been achieved, yet a greater insight is needed on the specificity of its response. In the first part of this thesis a novel mechanism in the regulation of p53-mediated apoptotic response has been disclosed. It has been demonstrated that upon severe stress signalling p53 dissociates from iASPP, an anti-apoptotic co-factor that inhibits p53 apoptotic functions, and that key roles in this process are played by the prolyl isomerase Pin1. Moreover, it emerged that phosphorylation at p53 Ser46 is required for Pin1-mediated dissociation of the p53-iASPP complex thus providing a mechanistic explanation for the relevance of this site in p53 mediated apoptosis. Notably, the role of Pin1 in assisting the dissociation of p53 from iASPP appears to be independent from Pin1-induced acetylation of p53 and dissociation from Mdm2, further confirming that Pin1 may modulate p53 activity at different levels. A different approach to gain insight on the mechanisms governing p53 regulation is the analysis of p53 protein interaction profiles. The bromodomain containing protein Brd7 was identified as a common interactor of the p53 family proteins in a yeast two hybrid screening conducted in our lab. The presence of the bromodomain and evidences from literature made Brd7 a promising candidate for modulating the p53 pathway at the transcriptional level. This protein and its functional interaction with p53 have been therefore characterized in the second part of this thesis. Upon depletion of Brd7 expression in cells it has been demonstrated that Brd7 is required for efficient cell-cycle arrest in U2OS cells upon challenging with genotoxic stimuli. This effect appeared to be due to a reduction in p21 expression that occurred upon Brd7 depletion and under stress condition. The down-regulation of p21 as a consequence of Brd7 silencing occurred at the transcriptional level and proved to be p53-depedent. Taken together the data reported in the second part of this thesis suggest a role for Brd7 as a positive regulator of p53 transcriptional activity during cell-cycle arrest response and that this function might be exerted by regulating p53-mediated transcription on a chromatin context. Further analysis is needed to dissct the role of this functional interaction. Yet, preliminary investigation suggest that Brd7 might be an important modulator of p53 response and that it can be an important means for p53 to crosstalk with other signalling pathway. Together, the data presented in this thesis contribute to achieve greater knowledge on the mechanism that govern p53 response. As the p53 pathway is compromised to some degree in almost all human cancers, this would be also of great relevance in designing new targeted strategies for cancer treatment.
Riassunto: Modulazione delle attività di p53 da parte della prolyl isomerasi Pin1 e della proteina contenente dominio Bromo Brd7 L’oncosoppressore p53 appartiene a una famiglia di fattori di trascrzione che svolge un ruolo fondamentale nel mantenimento della stabilità genomica e dell’omeostasi cellulare. L’attuazione di un’appropriata risposta cellulare dipende molto dalla regolazione fine delle funzioni di p53. Ciò avviene attraverso modificazioni post-traduzionali e interazioni con altre proteine cellulari. In molti anni di intenso studio si è raggiunta una notevole conoscenza sull’ attività di p53 ma ancora non è stato definito cosa regoli la specificità della risposta. Nella prima parte di questa tesi è stato portato alla luce un nuovo meccanismo nella regolazione della risposta apoptotica mediata da p53. E’ stato dimostrato che, in seguito a stress intensi, p53 si dissocia da iASPP, un co-fattore anti-apoptotico che inibisce le funzioni apoptotiche di p53 e che la prolyl-isomerasi in1 gioca un ruolo fondamentale in questo processo. In aggiunta è emerso che la fosforilazione di p53 al residuo Ser46 è necessaria al distacco di p53 da iASPP mediato da Pin1, fornendo una spiegazione meccanicistica alla nota rilevanza di questo siro per l’apoptosi mediata da p53. Interessantemente, il ruolo di Pin1 nell’assistere la dissociazione di p53 da iASPP sembra essere indipendente dalla sua capacità di favorirne l’acetilazione e il distacco da Mdm2, così confermando che Pin1 può modulare l’attività di p53 a diversi livelli. Un differente approccio per avere delucidazioni sui meccanismi che governano la regolazione di p53 è l’analisi del profilo di interazione proteica. La proteina Brd7 (contenente dominio Bromo) è stata identificata come comune interattore dei membri della famiglia di p53 in uno screening di doppio ibrido in lievito, condotto nel nostro laboratorio. La presenza del dominio Bromo e alcune evidenze di letteratura hanno reso Brd7 un candidato promettente come modulatore trascrizionale della via di segnalazione di p53. Brd7 e la sua interazione funzionale con p53 sono stati caratterizzati nella seconda parte di questa tesi. Dopo aver bloccato l’espressione di Brd7 in cellule è stato dimostrato che Brd7 è necessario per un efficiente arresto del ciclo cellulare in seguito a danni genotossici. Questo effetto sembra essere dovuto ad una riduzione nell’espressione di p21 che avviene I seguito alla deplezione di Brd7 e in condizioni di stress.Tale riduzione avviene a livello trascrizionale ed è p53-dipendente. Insieme I dati riportati nella seconda parte della tesi indicano un ruolo per Brd7 come regolatore positivo dell’attività trascrizionale di p53 durante l’arresto del ciclo cellulare e ciò può avvenire attraverso una regolazione a livello della cromatina. Insieme, I dati presentati in questa tesi contribuiscono ad una maggiore conoscenza sui meccanismi che governano la risposta di p53. Dato che la via di segnalazione di p53 è compromessa a qaulche livello in quasi tutti i tumori, questo potrebbe essere rilevante per disegnare nuove terapie mirate per la cura del cancro.
1978
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Comel, Anna. "p53 at the crossroads between cancer and neurodegeneration: unveiling molecular circuitries involved in tumorigenesis and neuronal cell death." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/10114.

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2012/2013
Cancer and neurodegeneration are linked by a relation of inverse comorbidity, cancer patients being at lower risk for neurodegenerative disorders and vice versa. Interestingly, many cellular processes and factors contribute to both pathologies, and a central role is played by the transcription factor p53. Best known for its antiproliferative activities following transformation-related stimuli, p53 acts to maintain genetic stability and prevent tumour onset by transcriptional and non-transcriptional mechanisms. Recently, a contribution of p53 also in neuronal development and death was unveiled. In the case of Huntington’s Disease (HD), p53 mediates cytotoxicity in HD cells and animal models, whereas its inhibition prevents this phenotype. On these premises, we were prompted to investigate the signalling pathways and protein interactions that modulate p53 activation in both cancer and neurodegeneration with the aim of identifying critical hubs as new targets for therapeutic intervention. We discovered that expression of HD causative agent, i.e. mutant Huntingtin (mHtt) protein, behaves like a genotoxic stimulus in inducing phosphorylation of p53 on Ser46, that leads to its modification by phosphorylation-dependent prolyl-isomerase Pin1 and consequent induction of apoptotic target genes. Inhibition of Ser46 phosphorylation by targeting HIPK2, PKCδ, or ATM kinases, as well as inhibition of Pin1, prevented mHtt-dependent apoptosis of neuronal cells. These results provide a rationale for the use of inhibitors of stress-responsive kinases and Pin1 as a potential therapeutic strategy for HD treatment. On the other hand, we investigated the contribution of BRD7, a protein involved in epigenetic regulation, to the p53 pathway. We found that BRD7 is required for the onset of oncogene-induced senescence, a main tumour suppressive p53 activity. In addition, we found that upon oncogene activation BRD7 restrains, independently of p53, the acquisition of malignant phenotypes, such as migration/invasion and stem cell traits. We observed a strong induction of inflammatory genes after depletion of BRD7, whose contribution to this process is still under investigation. BRD7 takes part into SWI/SNF and PRC2 chromatin remodelling complexes, whose pleiotropic roles in tumorigenesis make them appealing targets for cancer therapy. We will discuss how this new generated knowledge could be exploited for the treatment of neurodegenerative diseases, in which chromatin alterations are now recognized as drivers of pathogenesis.
XXV Ciclo
1983
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De, Deken Joachim. "A BRDF analysis of cloth." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/fullcit?p1477896.

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Thesis (M.S.)--University of California, San Diego, 2010.
Title from first page of PDF file (viewed July 14, 2010). Available via ProQuest Digital Dissertations. Includes bibliographical references (leaves 56-60).
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Kováčová, Kristýna. "Vyhlídková věž v oblasti Brdy." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2019. http://www.nusl.cz/ntk/nusl-392127.

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The subjekt of this thesis is a design of a viewing tower located in the area of Brdy. The structure has been created as a 3D model, the internal forces have been calculated with the use o finite element method in a structural engineering software Scia Engineer 15.1. Based on the knowledge of theses forces the design of the structural systems has been done. The materials used on this construction are glued laminated timber and steel. The height of the tower is 25,725 m. The floor plan is a shape of a circle and fluctuating smaller with the gaining height. The main structural systém consists of 8 curved posts which are radiály situated on the circular floor plan. The tower has 3 observational platforms.
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Tongbuasirilai, Tanaboon. "Accurate BRDF Modelling for Wide Angle Scattering." Thesis, Linköpings universitet, Medie- och Informationsteknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102746.

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In this thesis, a modified BRDF model for wide-angle scattering is presented. The proposed model is developed from empirical observations of several BRDF models. The model is an extention of the classical microfacet models. By replacing the two cosines of elevation angles with functions and exponent parameters, our model is able to give a special characteristic which we have not found in any other BRDF models. The characteristic at wide-angle scattering can be, for example, seen on the polyethylene material. In addition, our proposed model can greatly improve relative error from the reference model. The average relative error improvement is about 20 ercent for a cosine weighted error metric,E1 , and 10 percent for a logarithmic error metric, E 2,. Moreover, we also introduce a new optimization approach for the proposed terms. This approach can do optimization so that our proposed model gives at least an equivalent error to the reference model.
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Matěnová, Lucie. "Vývoj místní samosprávy v Mníšku pod Brdy." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-257346.

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The main aim of the thesis was determined to identify factors influencing political decisions of municipal government in Mníšek pod Brdy city. The Diploma Thesis is divided into three parts, the first of which is dedicated to local authorities, including their composition and powers, as well as issues of municipal elections, local political partisanship, and the participation of citizens in the conflict lines in local political space. Next part of this thesis was focused on indicators of proportionality elections and theories dealing with different views of the local coalition. The second part deals with the general characteristics of the city and its socio-economic structure. The last, main part of the Diploma Thesis is devoted to the presentation of each electoral period from 2002 till 2014. The principle of development and function of coalition within decision-making of the local government is described on the basis of analysis. In the end of the thesis factors, that influence coalition relationships and their reasons, are presented.
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Rahman, Shaila. "Molecular Insight into Function of the Evolutionarily Conserved Brd4 Extraterminal Domain (ET) and Mechanism of Brd4 Functions in Human Diseases." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10204.

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Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression and virus-host pathogenesis. Papillomaviruses (PV) E2 protein associates with Brd4 and this interaction is important for transcriptional regulation of the viral oncogenes by E2 as well as viral genome maintenance in host cells for some of the PV. Brd4 is causally linked to a rare, aggressive cancer, NUT Midline Carcinoma (NMC), which is typically defined by chromosomal translocation fusing the NUT gene to the Brd4 gene. The molecular mechanism behind Brd4-NUT oncogenesis remains largely unknown. To gain mechanistic insight into the biological functions of Brd4, we performed a proteomic analysis to identify and characterize Brd4 associated cellular proteins. We discovered binding partners of the Brd4 ET domain and show that interaction of these proteins with Brd4 is conserved across the human BET proteins. The Brd4 ET interactors, NSD3, JMJD6 and GLTSCR1, were found to be important for Brd4 transcriptional activation function and are recruited to the promoters they regulate in a Brd4 dependent manner. Moreover, depletion of Brd4 or NSD3 reduced H3K36 methylation demonstrating that the Brd4/NSD3 complex regulates the chromatin microenvironment. We thus identified the ET domain as an important transcription regulatory domain for Brd4. Since the ET domain is preserved in the Brd-NUT proteins, we also investigated its contribution to Brd-NUT pathogenesis. Expression of the ET domain, which competes off the ET domain interactors from Brd4-NUT, induced squamous differentiation. More specifically, depletion of the ET domain interactor, NSD3 induced squamous differentiation by Brd4-NUT while loss of JMJD6 markedly reduced proliferation of the NMC cells. Lastly, we investigated the effect of the recently developed small molecule inhibitors of BET bromodomains on PV E2 functions and papilloma virus mediated pathogenesis. BET inhibitors blocked association of Brd4 and E2 with mitotic chromosomes without affecting Brd4 dependent E2 transcription regulation of viral promoters. This finding suggests that Brd4 affects viral genome maintenance and viral transcription regulation via different mechanisms. Overall, these studies have shed new insight into the molecular mechanism of Brd4 functions and their role in human diseases.
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Řehořková, Jarmila. "Návrh řízení a propagace turistické destinace Brdy-Vltava." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-75182.

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The Brdy-Vltava destination lies in Central Bohemia region between the Brdy highlands and the river Vltava and has potential for tourism. But nowadays there is no organization of destination management and promotion. Promotion is not unified and coordinated. The purpose of this thesis is to propose which organisation should deal with management and promotion of the destination. The other aim is to propose activites of promotion and management and a way how to increase awareness of the destination. The author use the information not only from related literature but also from work experience for the town of Dobříš and Local action group Brdy-Vltava o.p.s.
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Boyer, Jacob, Janos C. Keresztes, Wouter Saeys, and John Koshel. "An automated imaging BRDF polarimeter for fruit quality inspection." SPIE-INT SOC OPTICAL ENGINEERING, 2016. http://hdl.handle.net/10150/622517.

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The purpose of this project was to test and implement recent research of polarization and scatter properties that suggest using a cross polarization imaging system to reduce glare artifacts. In particular, the use of this research is to improve the machine vision of apple quality detection in the food industry. The automated measurement system was implemented by acquiring pictures at different angles and different polarization states of apples. The opto-mechanics, system integration, synchronization and data collection are controlled with LabVIEW.
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Petzová, Terezie. "Možnosti rozvoje udržitelného cestovního ruchu na území CHKO Brdy." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359466.

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The diploma thesis deals with the development of sustainable tourism in protected areas. The aim of the thesis is to evaluate the possibilities of sustainable tourism development in the protected area. The theoretical part of the thesis deals with the issue in general terms. The problem is practically solved on the example of Brdy Protected Landscape Area (PLA). An identification for localization and implementation conditions for the development of sustainable tourism has been realized within the analysis of the examined areas potential. This identification was conducted as an empirical investigation with the representatives of the interested municipalities, local action groups and other organizations. The acquired knowledge has been reviewed with the PLA representatives opinions. Summarizing all gained knowledge, the PLA Brdy has been assessed as area that fulfils the prerequisites for the sustainable tourism development. Due to the character of the area, the development must be implemented only in the environment friendly forms.
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Books on the topic "Brd7"

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author, Simić Gordana, ed. Utvrđenja srednjovekovnog grada Novo Brda: Fortifications of the medieval town of Novo Brdo. Beograd: Republički Zavod Za Zašt.Spom.Kulture-Beograd, 2020.

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Prtenjača, Ivica. Brdo. Zagreb: V.B.Z., 2014.

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Grabersko brdo. Zagreb: Naprijed, 1992.

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1940-, Jovanović Vojislav V., ed. Novo Brdo. Beograd: Republički zavod za zaštitu spomenika kulture, 2004.

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Risojević, Ranko. Brdo: Pesme. Novi Sad: Svetovi, 1991.

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Bijelo brdo. Zagreb: Edicije Durieux, 1992.

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Fischer, Fritz. Der letzte Polyhistor: Leben und Werk von Arno Peters. Vaduz: Akad. Verl.-Anst., 1996.

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Brdo od marmelade. 2nd ed. Zagreb: Mozaik knijga, 2000.

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Sa kučkih brda. Podgorića: Narodna biblioteka "Radosav Ljumović", 1995.

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Brdo na okupu. Zagreb: Meandar, 1997.

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Book chapters on the topic "Brd7"

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Doppioslash, Claudia. "Implementing a BRDF." In Physically Based Shader Development for Unity 2017, 155–75. Berkeley, CA: Apress, 2017. http://dx.doi.org/10.1007/978-1-4842-3309-2_12.

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Haindl, Michal, and Votěch Havlíček. "BRDF Anisotropy Criterion." In Intelligent Information and Database Systems, 434–44. Cham: Springer Nature Switzerland, 2022. http://dx.doi.org/10.1007/978-3-031-21967-2_35.

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Guarnera, Dar’ya, and Giuseppe Claudio Guarnera. "Models of BRDF." In Virtual Material Acquisition and Representation for Computer Graphics, 15–47. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-031-02595-2_3.

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Tomasi-Kapral, Elżbieta. "Westdeutsche Rezeption – BRD." In Anna Seghers-Handbuch, 345–52. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05665-8_51.

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Glesner, Julia. "Zwischen Bedingung und Freiheit – Über die Zusammenarbeit zwischen Theaterbetrieben und ihren Aufsichtsgremien." In Cultural Governance, 187–201. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-32159-8_14.

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ZusammenfassungDer Erfolg von Theaterbetrieben hängt auch davon ab, wie erfolgreich die Zusammenarbeit zwischen der Leitung und den aufsichtsführenden Gremien des Betriebs abläuft. Abhängig von den wichtigsten Rechtsformen von Theaterbetrieben in der BRD – GmbH, Eigenbetrieb und Regiebetrieb – kommen den Parteien unterschiedliche Entscheidungs- und Einflussmöglichkeiten zu. Durch unzureichendes Gremienmanagement oder wenn das aufsichtsführende Gremium seine Verantwortung nicht in vollem Umfang übernimmt, geraten die Betriebe in Krisen mit Folgen, die auch die Zukunft des Modells „Stadttheater“ gefährden.
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Filip, J., and M. Haindl. "BTF Modelling Using BRDF Texels." In Advances in Machine Vision, Image Processing, and Pattern Analysis, 475–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11821045_50.

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Gooch, Jan W. "Bidirectional Reflectance Distribution Function (BRDF)." In Encyclopedic Dictionary of Polymers, 79. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_1288.

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Naegele, Gerhard. "Frühverrentung in der BRD." In Arbeit — Freizeit — Lebenszeit, 207–32. Wiesbaden: VS Verlag für Sozialwissenschaften, 1988. http://dx.doi.org/10.1007/978-3-322-84030-1_14.

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Burzlaff, H., and H. W. Zimmermann. "Germany, Fed. Rep. BRD." In World Directory of Crystallographers, 55–70. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-017-3701-2_21.

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Henninger, Annette. "Arbeitsmarktpolitik in der BRD." In Frauenförderung in der Arbeitsmarktpolitik, 14–22. Wiesbaden: VS Verlag für Sozialwissenschaften, 2000. http://dx.doi.org/10.1007/978-3-663-10101-7_2.

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Conference papers on the topic "Brd7"

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Mondal, Jayanta, Junfeng Zhang, Filippo G. Giancotti, and Jason Huse. "Loss of BRD7 promotes breast cancer lung metastasis by reprogramming the tumor immune microenvironment." In Leading Edge of Cancer Research Symposium. The University of Texas at MD Anderson Cancer Center, 2022. http://dx.doi.org/10.52519/00068.

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Burrows, Anna E., Agata Smogorzewska, and Stephen J. Elledge. "Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence." In Abstracts: Second AACR International Conference on Frontiers in Basic Cancer Research--Sep 14-18, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.fbcr11-a33.

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Nigro, Cristiana Lo, Daniela Vivenza, Ornella Garrone, Rodolfo Brizio, Fiamma Mantovani, Giannino Del Sal, Marco Carlo Merlano, and Tim Crook. "Abstract 2647: Bromodomain-containing protein 7 (BRD7) is a candidate tumor suppressor in breast carcinoma and prognostic biomarker." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2647.

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Hu, Kaishun. "Abstract 2377: Atm-dependent recruitment of brd7 is required for transcriptional repression and repair at dna breaks flanking transcriptional active regions." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2377.

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Choi, Sungwon, Kyeong-Sang Lee, Donghyun Jin, Darae Lee, and Kyung-Soo Han. "Retrieval of background surface reflectance with BRD components from pre-running BRDF." In SPIE Remote Sensing, edited by Adolfo Comerón, Evgueni I. Kassianov, and Klaus Schäfer. SPIE, 2016. http://dx.doi.org/10.1117/12.2241770.

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Matušková, Alena. "Rekonverze VÚ Brdy – základ rodící se oblasti cestovního ruchu (na příkladu západní části Brd)." In XIX. mezinárodní kolokvium o regionálních vědách. Sborník příspěvků. Brno: Masaryk university, 2016. http://dx.doi.org/10.5817/cz.muni.p210-8273-2016-140.

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Reilly, James P., Lorraine E. Kaczor, and Thomas A. Leonard. "10.6 Micron Wavelength BRDF Measurement on Low Reflectance A1 Samples." In Optical Fabrication and Testing. Washington, D.C.: Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oft.1990.othc4.

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McClain, Stephen C., and Russell A. Chipman. "Polarization BRDF." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1993. http://dx.doi.org/10.1364/oam.1993.the.4.

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By combining scatterometry with polarimetry, a polarization dependent BRDF is measured with the potential to separate roughness, contamination, and subsurface damage. Two instruments which measure the polarization BRDF will be presented and results discussed.
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Xie, Ming, Xiaochen Xie, Huanhuan Zhao, Xiaochun Wang, and Heping Tan. "Study on Comparison Experiment of the Bidirectional Reflectance Distribution Function (BRDF) of the Surface of Exterior Decorative Materials for Buildings Under Dry and Wet Condition." In 2010 14th International Heat Transfer Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ihtc14-22318.

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As Bidirectional Reflectance Distribution Function (BRDF) can describe the reflection and scattering characteristic of solid material surface better, an experiment which is based on the basic concept of BRDF and combined with the effects on surface profile from surface wettability theory and wet condition, was carried out for comparison. Using the white standard plate as a single sample for reference on a self-built experiment table, the BRDF values of the surface of three exterior decorative materials for buildings, namely granite, coated glass and Ethylene-Propylene-Diene-Monomer (EPDM), were measured under the conditions of dry and wet, on two wavebands (visible light band 0.6328μm and near infrared band 1.34μm) and at different incident angles. After the comparison of distribution, the results indicate that if forming stable water-film, which has the function of translucent smooth interface, above the surface of the three materials, their BRDF values will demonstrate obvious specular reflection component to different degree.
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Leonard, Thomas A., and James Reilly. "Establishment of a BRDF Standard Measurement Practice." In Optical Fabrication and Testing. Washington, D.C.: Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oft.1990.othc2.

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Nation-Wide BRDF round robin results at 0.6328 and 10.6 um showed the need for standardized scatter measurement/reporting procedures within the optical community. ASTM subcommittee E12.09 was formed in 1988 to address this need. This presentation reviews the round robin results, the work of E12.09 to promulgate a BRDF Standard Practice and work on a 10.6 um physical scatter reference.
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Reports on the topic "Brd7"

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Deshpande, Alina. BRD usability requirements. Office of Scientific and Technical Information (OSTI), March 2015. http://dx.doi.org/10.2172/1172866.

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White, H. P., L. Sun, C. Champagne, K. Staenz, and S G Leblanc. BRDF Normalization of Hyperspectral Image Data. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2002. http://dx.doi.org/10.4095/219888.

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Crockett, Gregg. Laser Range Safety Tool (LRST) BRDF Reference. Fort Belvoir, VA: Defense Technical Information Center, September 2003. http://dx.doi.org/10.21236/ada417649.

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Priest, Richard G., and Thomas A. Gerner. Polarimetric BRDF in the Microfacet Model: Theory and Measurements. Fort Belvoir, VA: Defense Technical Information Center, March 2000. http://dx.doi.org/10.21236/ada394526.

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Trishchenko, A., Z. Li, W. M. Park, and J. Cihlar. BRDF Effects in Satellite Retrieval of Surface Spectral Reflectance in Solar Spectral Region. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2000. http://dx.doi.org/10.4095/219775.

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Leblanc, S. G., and J. M. Chen. A Windows Graphic User Interface (GUI) for the Five-Scale Model for Fast BRDF Simulations. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2000. http://dx.doi.org/10.4095/219733.

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Trishchenko, A., K. Khlopenkov, and Y. Luo. Retrieval of BRDF for pure landcover types from MODIS and MISR using an angular unmixing approach. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2004. http://dx.doi.org/10.4095/220098.

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Hamermesh, Daniel. Policy Transferability and Hysteresis: Daily and Weekly Hours in the BRD and the US. Cambridge, MA: National Bureau of Economic Research, June 1994. http://dx.doi.org/10.3386/w4773.

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Boynton, G. C., and K. J. Voss. Shallow Ocean Bottom BRDF Prediction, Modeling, and Inversion via Simulation with Surface/Volume Data Derived from X-ray Tomography. Fort Belvoir, VA: Defense Technical Information Center, January 2008. http://dx.doi.org/10.21236/ada516687.

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Boynton, G. C., and K. J. Voss. Shallow Ocean Bottom BRDF Prediction, Modeling, and Inversion via Simulation with Surface/Volume Data Derived from X-Ray Tomography. Fort Belvoir, VA: Defense Technical Information Center, January 2006. http://dx.doi.org/10.21236/ada522154.

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