Dissertations / Theses on the topic 'Brain tumour'
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Cubis, Lee M. "Staying Connected after Brain Tumour: Changes in Social Networks and Relationship to Wellbeing after Brain Tumour." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/395565.
Full textThesis (Professional Doctorate)
Doctor of Philosophy in Clinical Psychology (PhD ClinPsych)
School of Applied Psychology
Griffith Health
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Zumel, Marne María Ángela 1984. "Environmental factors and brain tumour risk in young people." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668182.
Full textLos factores de riesgo y el diagnóstico en los jóvenes han sido poco explorados, a pesar de que los tumores cerebrales (TC) son uno de los tipos de tumores más frecuentes en los niños y jóvenes. El propósito de esta tesis doctoral es el estudio de 1) de las características clínicas y los síntomas de los TC en los jóvenes, basados en el estudio internacional de casos y controles MOBI-Kids; 2) una revisión sistemática de la literatura sobre el riesgo de TC en jóvenes en relación con factores ambientales; 3) el riesgo de TC en relación con los productos químicos presentes en el agua potable y con los metales pesados. Los análisis de las características clínicas revelaron que la gran mayoría de los tumores eran neuroepiteliales (principalmente gliomas), seguidos de tumores embrionarios y meningiomas. En general, los síntomas más frecuentes fueron dolor de cabeza, seguido de signos y síntomas neurológicos focales, náuseas/ vómitos y problemas en la visión, siendo un 4% de los casos asintomáticos. El tiempo promedio de diagnóstico tendió a ser corto (mediana 1,42 meses), aunque esto varió según el tipo de tumor, la edad y el tipo de síntoma. Encontré muchos estudios que encontraron asociación entre los factores ambientales (incluido el humo del tabaco, los pesticidas y la dieta, entre otras exposiciones) y el riesgo de TC en la revisión sistemática. Sin embargo, debido a limitaciones metodológicas, la evidencia sobre el papel de estos factores en la etiología de esta enfermedad aún es incierta. Nuestros análisis en relación con los productos químicos del agua mostraron unos OR por debajo de 1 para exposiciones a THMs, y OR por encima de 1 para exposición a nitrato, tanto en períodos de exposición prenatales como postnatales, algunos estadísticamente significativos. Nuestros análisis de metales pesados mostraron ORs por debajo de 1 para la exposición al cromo. Sin embargo, la literatura es escasa sobre esta asociación. En general, esta tesis sirvió para llenar un vacío en el conocimiento sobre 1) las características clínicas de la TC en los jóvenes, útiles tanto para la práctica clínica como para la investigación etiológica; 2) causas de esta enfermedad; 3) el papel de los metales pesados y los químicos ubicuos en el agua. Se ha identificado la necesidad de realizar más investigaciones sobre la etiología y la prevención de las TC en los jóvenes.
Richards, R. "Understanding the role of the solid tumour microenvironment in brain tumour progression." Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3005579/.
Full textPedapati, Praveena, and Rama Vaishnavi Tannedi. "BRAIN TUMOUR DETECTION USING HOG BY SVM." Thesis, Blekinge Tekniska Högskola, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-15905.
Full textJaroudi, Rym. "Inverse Mathematical Models for Brain Tumour Growth." Licentiate thesis, Linköpings universitet, Tekniska fakulteten, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-141982.
Full textJordaan, Carike. "The relationship between tumour characteristics, depressive symptoms, and neuropsychological profiles in brain tumour patients." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96700.
Full textENGLISH ABSTRACT : Worldwide there are various reports on the prevalence of depression in patients diagnosed with brain tumours. In South Africa, psychological research in relation to psychiatric symptoms among patients with brain tumours is lacking. The aims of this study were to determine the incidence of depression in patients diagnosed with brain tumours and to clarify our understanding of the relationship between depression and tumour localisation, histopathological type of tumour, and participant characteristics. The study sample consisted of 35 patients (11 males and 24 females) aged between 21 and 64 years with a solitary primary brain tumour. The patients were treated at the neurosurgery clinics located at Tygerberg Hospital in the Western Cape and Universitas Hospital in the Free State between mid-2010 and 2013. The major histological subgroup consisted of meningiomas (47%), glioblastomas (22%), astrocytomas (19%), gliomas (9%) and epidiomas (3%). The tumour distribution was as follows: 52% in the left hemisphere, 37% in the right hemisphere, and 11 % in the midline. The psychiatric symptoms of the patients were assessed before treatment by the Beck Depression Inventory and Mini International Neuropsychiatric Interview. In addition, the patients’ neuropsychological functions were evaluated by a short neuropsychological test battery (Mini Mental State Examination, Trail Making Test (Part A), Letter Number Sequencing subtest, Hopkins Verbal Learning Test – Revised, and Brief Visuospatial Memory Test – Revised). Results from the quantitative data, showed the prevalence of mild depression was 26% for men and 43% for women. Overall 37% of the total sample had depressive symptoms. No significant relationship was found between depression and tumour location or between the various neuropsychological characteristics and neurological symptoms and tumour location. The study showed that depression is a common symptom in patients diagnosed with brain tumours and therefore depression symptoms have to be recognised and treated by psycho-educating the patients and their families, pharmacotherapy, or psychotherapy as soon as possible. However, due to the relatively small sample size, the results are of limited generalisability.
AFRIKAANSE OPSOMMING : Wêreldwyd is daar verskeie verslae oor die voorkoms van depressie in pasiënte gediagnoseer met breingewasse. In Suid-Afrika is daar ’n tekort aan sielkundige navorsing met betrekking tot psigiatriese simptome by pasiënte. Die doel van hierdie studie was om die voorkoms van depressie te bepaal in pasiënte gediagnoseer met breingewasse en om duidelikheid te kry oor die verband tussen depressie en die ligging van breingewasse, histopatologiese tipe gewas en karakter eienskappe van die deelnemers. Die steekproef van die studie het bestaan uit 35 pasiënte (11 mans en 24 vroue) tussen die ouderdomme 21 en 64 jaar met ‘n soliede breingewas. Die pasiënte is behandel by die neurochirurgiese klinieke by Tygerberg Hospitaal in die Wes-Kaap en by Universitas Hospitaal in die Vrystaat vanaf middel 2010 tot 2013. Die mees algemene histologiese subgroep het bestaan uit meningiome (47%), glioblastomas (22%), astrocytomas (19%), gliomas (9%) en epidiomas (3%). Die verspreiding van die gewasse was soos volg: 52% in die linkerhemisfeer, 37% in die regterhemisfeer en 11% in die middel. Die psigiatriese simptome van die pasiënte is voor behandeling geëvalueer met behulp van die Beck Depression Inventory en die Mini International Neuropsychiatric Interview. Bykomend is die pasiënte se neurosielkundige funksies geëvalueer met behulp van ‘n neurosielkundige toetsbattery (Mini Mental State Examination, Trail Making Test (Part A), Letter Number Sequencing subtest, Hopkins Verbal Learning Test – Revised en Brief Visuospatial Memory Test – Revised). Die resultate van die kwantitatiewe data het getoon die voorkoms van matige depressie was 26% vir mans en 43% vir vroue. In geheel het 37% van die totale steekproef depressiewe simptome getoon. Daar was geen beduidende verhouding tussen depressie en die ligging van die gewas of tussen die verskeie neurosielkundige eienskappe en die ligging van die gewas nie. Die studie het getoon dat depressie ’n algemene simptoom is in pasiënte gediagnoseer met breingewasse en daarom moet depressiewe simptome herken en so gou as moontlik behandel word deur psigo-opvoeding van die pasiënte en hul familie, farmakoterapie of psigoterapie. As gevolg van die relatiewe klein steekproef grootte het die resultate ’n beperkte veralgemeenbaarheid.
Christidou, Maria. "The role of flavonoids on brain tumour invasion." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414780.
Full textLi, Xiaofei. "The IL-33/ST2 pathway in CNS : Traumatic brain injury and brain tumour." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183937.
Full textShen, Shan. "MRI brain tumour classification using image processing and data mining." Thesis, University of Strathclyde, 2004. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21543.
Full textMcgahan, Jennifer Anne. "Exploring memory and memory rehabilitation in paediatric brain tumour survivors." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/exploring-memory-and-memory-rehabilitation-in-paediatric-brain-tumour-survivors(194abbcb-6a1a-47aa-bbe7-8cca023f659f).html.
Full textPigot, T. J. D. "Clinical and cellular prognostic variables in glioblastoma multiforme." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277401.
Full textGrant, John William. "Immunohistochemistry in the diagnosis and characterisation of neoplasms affecting the central nervous system." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278778.
Full textThwaites, Charlene Louise. "Neural correlates of verbal fluency and associations with demographic, mood, cognitive and tumour factors in brain tumour patients." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22711/.
Full textBennett, Emily. "Predicting parenting stress in caregivers of children treated for brain tumour." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537800.
Full textPauly-Takacs, Katalin. "Learning and episodic memory following childhood brain tumour : a case study." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590298.
Full textChoy, Catherine Theresa. "Kallmann syndrome-associated protein anosmin-1 contributes to brain tumour malignancy." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.656859.
Full textBruce, M. "Posttraumatic stress symptoms in childhood brain tumour survivors and their parents." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445380/.
Full textJaworek, Karolina. "Screening for novel brain tumour initiation mechanisms at single cell resolution." Thesis, Bangor University, 2016. https://research.bangor.ac.uk/portal/en/theses/screening-for-novel-brain-tumour-initiation-mechanisms-at-single-cell-resolution(3bb44859-bc78-4fce-a7df-0f47d2dd6b4e).html.
Full textDe, Mattos Arruda Leticia. "Genomic characterisation of brain malignancies through liquid biopsies: The cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/394019.
Full textRecent developments in massively parallel sequencing and digital genomic techniques support the clinical validity of cell-free circulating tumour DNA (ctDNA) as a ‘liquid biopsy’ in human cancer. ctDNA in plasma may be useful to identify actionable genomic alterations, monitor treatment responses, unravel therapeutic resistance, and potentially to characterise tumour heterogeneity. The proof-of-principle study in the field of liquid biopsies, which is the ancillary article analysed in this thesis entitled: “Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle” was published in Annals of Oncology in July 2014. This article is one of the first to demonstrate that high-depth targeted massively parallel sequencing of plasma-derived ctDNA constitutes a potential tool for de novo mutation identification and monitoring of somatic genomic alterations during the course of targeted therapy. This article demonstrated that plasma ctDNA may be employed to overcome the challenges posed by tumour heterogeneity. Plasma-derived ctDNA has been shown to be informative of the genomic alterations of patients with cancers. Nevertheless, patients with brain tumours have low or undetectable amounts of ctDNA in plasma precluding the genomic characterisation of brain cancer through plasma ctDNA. The proof-of-principle in the field of central nervous system liquid biopsies, which the fundamental article analysed in this thesis entitled: “Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma” was published in Nature Communications in November 2015. ctDNA derived from primary and secondary central nervous system malignancies was shown to be more abundantly present in the cerebrospinal fluid (CSF) than in plasma and it portrayed the genomic alterations of central nervous system disease better than plasma. CSF ctDNA levels longitudinally fluctuated in time and followed the changes in brain tumour burden providing biomarkers to monitor brain malignancies. Additionally, CSF ctDNA was shown to facilitate and complement the diagnosis of leptomeningeal carcinomatosis. Taken together, ctDNA present in the CSF of brain malignancies and ctDNA present in the plasma of breast cancers with extra-cranial systemic metastases may be used to characterise metastasis-specific genomic alterations. CSF ctDNA represents a minimally invasive tool that may change the paradigm for the clinical management of cancer patients with central nervous system malignancies. Liquid biopsies have the potential to provide comprehensive, sequential and real-time tumour-derived genomic information that will improve the therapeutic management of cancer patients.
LeCouteur, Richard Andrew. "Novel approaches to the diagnosis and treatment of brain tumours, and other investigations in clinical neurology." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25082.
Full textLe, Couteur Richard Andrew. "Novel approaches to the diagnosis and treatment of brain tumours, and other investigations in clinical neurology." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27406.
Full textVouri, Mikaella. "The role of TAM receptors in brain tumour cell signalling and behaviour." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/the-role-of-tam-receptors-in-brain-tumour-cell-signalling-and-behaviour(df1c22b0-d917-4960-a96d-49ed30a3e91d).html.
Full textVicente, Robledo Javier. "Clinical Decision Support Systems for Brain Tumour Diagnosis: Classification and Evaluation Approaches." Doctoral thesis, Editorial Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/17468.
Full textVicente Robledo, J. (2012). Clinical Decision Support Systems for Brain Tumour Diagnosis: Classification and Evaluation Approaches [Tesis doctoral]. Editorial Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/17468
Palancia
Petch, Amelia K. "DNA chip designed antisense oligodeoxynucleotides targeting EGFR MRNA for brain tumour therapy." Thesis, Aston University, 2002. http://publications.aston.ac.uk/10998/.
Full textLurie, P. "Coping with a childhood brain tumour : a qualitative analysis of parents' experiences." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1448225/.
Full textBalathasan, Lukxmi. "Characterising the role of circulating immune cells in brain metastasis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e7620d30-7e4a-468b-b819-db4cf27eaef6.
Full textIvanov, Delyan Pavlov. "Assessment of drug-loaded nanoparticles in a 3D in vitro brain tumour model." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/43559/.
Full textBrown, Frances Kessler. "Memory After Tumours of the CNS in Childhood (MATCCh) study : long-term memory and forgetting in paediatric brain tumour survivors." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6719/.
Full textCavers, Debbie Grant. "Understanding the supportive care needs of glioma patients and their relatives : a qualitative longitudinal study." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/10630.
Full textVilamala, Muñoz Albert. "Multivariate methods for interpretable analysis of magnetic resonance spectroscopy data in brain tumour diagnosis." Doctoral thesis, Universitat Politècnica de Catalunya, 2015. http://hdl.handle.net/10803/336683.
Full textEls tumors cerebrals malignes representen un dels tipus de càncer més difícils de tractar degut a la sensibilitat de l’òrgan que afecten. La gestió clínica de la patologia esdevé encara més complexa quan la massa tumoral s'incrementa degut a la proliferació incontrolada de cèl·lules; suggerint que una diagnosis precoç i acurada és vital per prevenir el curs natural de desenvolupament. La pràctica clínica estàndard per a la diagnosis inclou la utilització de tècniques invasives que poden arribar a ser molt perjudicials per al pacient, factor que ha fomentat la recerca intensiva cap al descobriment de mètodes alternatius de mesurament dels teixits del cervell, tals com la ressonància magnètica nuclear. Una de les seves variants, la imatge de ressonància magnètica, ja s'està actualment utilitzant de forma regular per localitzar i delimitar el tumor. Així mateix, una variant complementària, la espectroscòpia de ressonància magnètica, malgrat la seva alta resolució espacial i la seva capacitat d'identificar metabòlits bioquímics que poden esdevenir biomarcadors de tumor en una àrea delimitada, està molt per darrera en termes d'ús clínic, principalment per la seva difícil interpretació. Per aquest motiu, la interpretació dels espectres de ressonància magnètica corresponents a teixits del cervell esdevé un interessant camp de recerca en mètodes automàtics d'extracció de coneixement tals com l'aprenentatge automàtic, sempre entesos com a una eina d'ajuda per a la presa de decisions per part d'un metge expert humà. La tesis actual té com a propòsit la contribució a l'estat de l'art en aquest camp mitjançant l'aportació de noves tècniques per a l'assistència d'experts radiòlegs, centrades en problemes complexes i proporcionant solucions interpretables. En aquest sentit, s'ha dissenyat una tècnica basada en comitè d'experts per a una discriminació acurada dels diferents tipus de tumors cerebrals agressius, anomenats glioblastomes i metàstasis; a més, es proporciona una estratègia per a incrementar l'estabilitat en la identificació de biomarcadors presents en un espectre mitjançant una ponderació d'instàncies. Des d'una perspectiva analítica diferent, s'ha desenvolupat una eina basada en la separació de fonts, guiada per informació específica de tipus de tumor per a avaluar l'existència de diferents tipus de teixits existents en una massa tumoral, quantificant-ne la seva influència a les regions tumorals veïnes. Aquest desenvolupament ha portat cap a la derivació d'una interpretació probabilística d'algunes d'aquestes tècniques de separació de fonts, proporcionant suport per a la gestió de la incertesa i estratègies d'estimació del nombre més acurat de teixits diferenciats en cada un dels volums tumorals analitzats. Les estratègies proporcionades haurien d'assistir els experts humans en l'ús d'eines automatitzades de suport a la decisió, donada la interpretabilitat i precisió que presenten des de diferents angles.
Seyed, Sadr Mohamad. "SLIT proteins inhibit malignant brain tumour cell invasion via downregulation of pro-invasive genes." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110340.
Full textLa transformation d'une tumeur primaire en tumeur maligne et métastatique, s'éloignant du point d'origine, est souvent la principale cause de décès chez le patient. Les tumeurs cérébrales malignes tel les glioblastomes et les médulloblastomes sont parmi les plus invasives cancers humains. La voie de signalisation de Slit-Robo a été largement caractérisée et montre l'implication de Slit-Robo dans la répulsion des axones et cellules neuronales. Dans cette étude, nous avons étudié la possibilité que Slit-Robo pourraient repousser les cellules cancéreuses invasives cérébrales. Le premier chapitre de cette thèse présente une introduction approfondie du rôle de la famille des protéines Slit-Robo dans le contexte du cancer et de la biologie des tumeurs cérébrales. Le deuxième chapitre présente des preuves de l'implication des protéines Slit et leur rôle dans l'inhibition de l'invasion des cellules de tumeurs cérébrales. Aussi, la caractérisation de la voie de signalisation employée par les protéines Slit dans l'inhibitionde l'invasion des cellules cancéreuses a été montrée. De plus, cette étude présente des résultats qui suggèrent que les protéines Slit diminuent l'expression de la transcription degènes pro-angiogénique et pro-invasif des cellules tumorales. Nous avons aussi identifié MMP14 comme une protéase des protéines Robo et dont l'expression est influencée par les protéines Slit. Finalement, nous proposons un modèle démontrant qu'une diminution de l'expression de MMP14 induit une réduction de l'invasion des cellules tumorales du cerveau.
Cowman, S. J. "Elucidation of the effects of hypoxia on DNA repair machinery in brain tumour cells." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3028185/.
Full textKinyany-Schlachter, Susan. "Woman as healer : a dialogical narrative analysis of online brain tumour (GBM) caregiving stories." Thesis, City, University of London, 2017. http://openaccess.city.ac.uk/19801/.
Full textCea, Leire. "Psychosocial adjustment of children who have ended brain tumour treatment: child and parent reports." Thesis, Högskolan för lärande och kommunikation, Jönköping University, HLK, CHILD, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-50860.
Full textScotland, Jennifer L. "Inspection time in patients with intracranial tumours before and after neurosurgery." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4425.
Full textBrem, Franziska Katharina. "Magnetic characterisation of iron phases in human brain tissue: Applications to epileptic and tumour tissue /." Zürich : ETH, 2006. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16739.
Full textNajim, Nigar. "A study of the cytotoxic effects of methionine depletion in human brain tumour cell lines." Thesis, University of Salford, 2007. http://usir.salford.ac.uk/26832/.
Full textDungey, Fiona A. "Targeting replication-specific DNA repair pathways to enhance the therapeutic ratio of brain tumour radiotherapy." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506947.
Full textOpstad, Kirstie Suzanne. "Quantification and pattern recognition of ¹H magnetic resonance brain tumour spectra for automated classification." Thesis, St George's, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413702.
Full textChakraborty, Aabir. "The development of intra-operative ultrasound elasticity imaging techniques to assist during brain tumour resection." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446165/.
Full textBallantyne, Eric Sinclair. "The expression and prognostic role of proto-oncogenes and tumour suppressor genes in medulloblastoma and embryonic brain." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366487.
Full textGaskill, Alexandra Mary Angela. "Adolescent girls' experiences of school following treatment for a brain tumour : an interpretative phenomenological analysis approach." Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/29154.
Full textFletcher, Kimberley J. "An interpretative phenomenological analysis of the patient experience of awake craniotomy : brain tumour diagnosis to discharge." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12124/.
Full textAlderson, William. "Automatic brain tumour detection and segmentation using tissue substructure features derived from MRI diffusion tensor imaging." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.688350.
Full textTaggart, David John. "Cross-talk between the primary tumour and brain metastases enhances the efficacy of immune checkpoint inhibition." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16116/.
Full textWestermark, Hanna. "Deep Learning with Importance Sampling for Brain Tumor MR Segmentation." Thesis, KTH, Optimeringslära och systemteori, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-289574.
Full textSegmentering av magnetröntgenbilder är en viktig del i planeringen av strålbehandling av patienter med hjärntumörer. Det höga antalet bilder och den nödvändiga precisionsnivån gör dock manuellsegmentering till en tidskrävande uppgift. Faltningsnätverk har därför föreslagits som ett verktyg förautomatiserad segmentering och visat lovande resultat. Datamängderna som används för att träna dessa djupinlärningsmodeller är ofta obalanserade och innehåller data som inte bidrar till modellensprestanda. Det finns därför potential att både skynda på träningen och förbättra nätverkets förmåga att segmentera tumörer genom att noggrant välja vilken data som används för träning. Denna uppsats implementerar importance sampling för att träna ett faltningsnätverk för patch-baserad segmentering av tredimensionella multimodala magnetröntgenbilder av hjärnan. Modellensträningstid och prestanda jämförs mot ett nätverk tränat med standardmetoden. Detta görs förtvå olika storlekar på patches. Egenskaperna hos de mest valda volymerna analyseras också. Importance sampling uppvisar en snabbare träningsprocess med avseende på antal epoker och resulterar också i modeller med högre prestanda. Analys av de oftast valda volymerna indikerar att under träning med stora patches förekommer små tumörer i en något högre utsträckning. Vidareundersökningar är dock nödvändiga för att bekräfta vilka aspekter som påverkar hur ofta en volym används.
Stevens, Laura Louise. "An in vivo study of angiogenesis in a brain tumour model by dynamic contrast-enhanced CT scanning." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ32513.pdf.
Full textJones, Timothy L. "A novel magnetic resonance diffusion tensor imaging segmentation and visualisation technique for brain tumour diagnosis and surveillance." Thesis, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589799.
Full textTorrealdea, F. "Investigation of brain tumour metabolism using naturally occurring chemical exchange saturation transfer agents with magnetic resonance imaging." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1490928/.
Full textHart, Michael Gavin. "Network approaches to understanding the functional effects of focal brain lesions." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274018.
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