Dissertations / Theses on the topic 'Brain – Spectroscopic imaging'
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Parikh, Jehill. "Measurement of brain temperature using magnetic resonance spectroscopic imaging." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8082.
Full textWild, James Michael. "Proton magnetic resonance spectroscopic imaging of the human brain." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/22742.
Full textKok, Trina. "Magnetic resonance spectroscopic imaging with 2D spectroscopy for the detection of brain metabolites." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/78450.
Full textCataloged from PDF version of thesis. Page 94 blank.
Includes bibliographical references (p. 87-93).
While magnetic resonance imaging (MRI) derives its signal from protons in water, additional biochemical compounds are detectable in vivo within the proton spectrum. The detection and mapping of these much weaker signals is known as magnetic resonance spectroscopy or spectroscopic imaging. Among the complicating factors for this modality applied to human clinical imaging are limited chemical-shift dispersion and J-coupling, which cause spectral overlap and complicated spectral shapes that limit detection and separation of brain metabolites using MR spectroscopic imaging (MRSI). Existing techniques for improved detection include so-called 2D spectroscopy, where additional encoding steps aid in the separation of compounds with overlapping chemical shift. This is achieved by collecting spectral data over a range of timing parameters and introducing an additional frequency axis. While these techniques have been shown to improve signal separation, they carry a penalty in scan time that is often prohibitive when combined with MRSI. Beyond scan time constraints, the lipid signal contamination from the subcutaneous tissue in the head pose problems in MRSI. Due to the large voxel size typical in MRSI experiments, ringing artifacts from lipid signals become more prominent and contaminate spectra in brain tissue. This is despite the spatial separation of subcutaneous and brain tissue. This thesis first explores the combination of a 2D MRS method, _Constant Time Point REsolved SpectroScopy (CT-PRESS) with fast spiral encoding in order to achieve feasible scan times for human in-vivo scanning. Human trials were done on a 3.OT scanner and with a 32-channel receive coil array. A lipid contamination minimization algorithm was incorporated for the reduction of lipid artifacts in brain metabolite spectra. This method was applied to the detection of cortical metabolites in the brain and results showed that peaks of metabolites, glutamate, glutamine and N-acetyl-aspartate were recovered after successful lipid suppression. The second task of this thesis was to investigate under-sampling in the indirect time dimension of CT-PRESS and its associated reconstruction with Multi-Task Bayesian Compressed Sensing, which incorporated fully-sampled simulated spectral data as prior information for regularization. It was observed that MT Bayesian CS gave good reconstructions despite simulated incomplete prior knowledge of spectral parameters.
by Trina Kok.
Ph.D.
Arango, Nicolas(Nicolas S. ). "Sequence-phase optimal (SPO) [d̳e̳l̳t̳a̳]B₀ field control for lipid suppression and homogeneity for brain magnetic resonance spectroscopic imaging." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/128411.
Full textCataloged from PDF version of thesis. [d̳e̳l̳t̳a̳] in title on title page appears as upper case Greek letter.
Includes bibliographical references (pages 33-35).
This work develops sequence-phase optimal (SPO) [delta]B₀ shimming methods to reduce lipid contamination and improve brain metabolite spectra in proton spectroscopic imaging. A rapidly reconfigurable 32-channel, local-multi-coil-shim-array is used to enhance lipid suppression and narrow metabolite linewidth in magnetic resonance spectroscopic imaging (MRSI) of the brain. The array is optimally reconfigured dynamically during each MRSI repetition period, first during the lipid-suppression phase, by widening the spectral gap between spatially separate lipid and metabolite regions, and then to narrow metabolite linewidth during readout, by brain-only [delta]B₀ homogenization. This sequence-phase-optimal (SPO) shimming approach is demonstrated on four volunteer subjects using a commercial 3T MRI outfitted with a 32-channel integrated RF receive and local multi-coil shim array. This proposed sequence-phase-optimal shimming significantly improves brain-metabolite MRSI in vivo, as measured by lipid suppression, brain metabolite chemical shift, and line widths. The time required to compute patient specific SPO shims negligibly impacted scan time. Sequence-phase-optimal shimming reduced lipid energy in the brain volume across four subjects by 88%, improved NAA FWHM by 23%, and dramatically reduced lipid ringing artifacts in quantified NAA and Glutamate metabolites, without increasing scan time or SAR.
by Nicolas Arango.
S.M.
S.M. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
Gudmundson, Erik. "Signal Processing for Spectroscopic Applications." Doctoral thesis, Uppsala universitet, Avdelningen för systemteknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120194.
Full textRoss, Amy Psychiatry Faculty of Medicine UNSW. "Longitudinal study of cognitive and functional brain changes in ageing and cerebrovascular disease, using proton magnetic resonance spectroscopy." Awarded by:University of New South Wales. School of Psychiatry, 2005. http://handle.unsw.edu.au/1959.4/27329.
Full textLabadie, Christian. "Gradient-echo pulse sequence development for phase sensitive magnetic resonance imaging : application to the detection of metabolites and myelin water in human brain white matter." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10134.
Full textTwo magnetic resonance imaging methods are proposed for the in vivo investigation of human brain white matter tissue. The first method allows the ultra-fast acquisition of maps of brain metabolites by repeating the sampling of k-space at intervals of a few milliseconds, with a center-out trajectory combined with flyback gradients. A phase-correction procedure is introduced to prevent the formation of aliasing artifacts in the image and in the spectrum, on the basis of parameters determined from the signal of the ubiquitous water protons. An acquisition of threedimensional metabolite maps of creatine, choline, N-acetylaspartate, glutamate, and myo-inositol were determined reliably in human brain white matter at 3 Tesla with a 32 × 32 × 16 matrix and a 7-mm isotropic resolution. The second method enables the acquisition of a train of 32 images geometrically sampled along an inversion-recovery curve, using a series of gradient echoes excited by a low 5° flip angle to avoid saturation effects. After inverse Laplace transform, using a spatial regularization, a continuous distribution of the spin-lattice relaxation times, T1, is obtained. In the region of T1 between 100 ms and 230 ms, a small component is attributed to water hydrating myelin membranes. The apparent fraction of this myelin water component increases with the strength of the magnetic field, from 8.3% at 3 Tesla, to 11.3% at 4 Tesla, and 15.0% at 7 Tesla
Chiu, Pui-wai, and 趙沛慧. "¹H and ³¹P brain magnetic resonance spectroscopy in aging." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47170505.
Full textpublished_or_final_version
Diagnostic Radiology
Master
Master of Philosophy
Lebel, Cynthia. "Optical Brain Imaging of Motor Cortex to Decode Movement Direction using Cross-Correlation Analysis." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1609111/.
Full textHall, Michael A. "Temporal Mapping and Connectivity using NIRS for Language Related Tasks." FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/560.
Full textRothmeier, Greggory H. "Brain tissue temperature dynamics during functional activity and possibilities for optical measurement techniques." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/phy_astr_theses/14.
Full textOeltzschner, Georg [Verfasser], Alfons [Akademischer Betreuer] Schnitzler, and Thomas [Akademischer Betreuer] Heinzel. "Magnetic resonance spectroscopy and quantitative brain water imaging in patients with hepatic encephalopathy / Georg Oeltzschner. Gutachter: Alfons Schnitzler ; Thomas Heinzel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1081214538/34.
Full textStorrs, Judd M. "Automatic Real-time Targeting of Single-Voxel Magnetic Resonance Spectroscopy." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282576722.
Full textMyllylä, T. (Teemu). "Multimodal biomedical measurement methods to study brain functions simultaneously with functional magnetic resonance imaging." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526205076.
Full textTiivistelmä Multimodaalisia kuvantamismenetelmiä käytetään enenevässä määrin ihmisen fysiologian ja elintoimintojen tutkimisessa. Erityisesti aivotutkimuksessa samanaikaisesti useammalla modaliteetilla mittaaminen mahdollistaa erilaisten fysiologisten mekanismien ja niiden korrelaatioiden tutkimisen kehon ja aivotoimintojen välillä. Lisäksi multimodaaliset mittaukset auttavat yksilöimään fysiologiset komponentit toisistaan ja identifioimaan aivojen tuottamia fysiologisia signaaleja. Tämä väitöskirja kokoaa tutkimustyön sekä laite- ja instrumentointisuunnittelun ja sen kehittämistyön ei-invasiivisesti toteutettujen lääketieteen mittausmenetelmien käyttämiseksi magneettikuvauksen aikana. Erityishaasteena työssä on ollut magneettikuvausympäristö, joka asettaa erityisvaatimuksia mm. mittalaitteissa käytettäville materiaaleille sekä laitteiden häiriönsiedolle magneettikuvauslaitteen aiheuttaman voimakkaan magneettikentän takia. Kehitettävät mittausmenetelmät eivät myöskään saa aiheuttaa häiriöitä magneettikuvauslaitteen tuottamalle kuvainformaatiolle. Väitöskirjassa esitettävät mittausmenetelmät tekevät mahdolliseksi mitata magneettikuvausympäristössä ihmisen sydämen sykettä, veren virtauksen kulkunopeutta ja verenpaineen vaihteluja sekä aivokuoren metaboliaa - kaikki synkronissa aivosähkökäyrän mittaamisen ja magneettikuvantamisen kanssa. Lisäksi väitöskirjassa tutkitaan kehitettyjen mittausmenetelmien antamaa mittaustarkkuutta sekä arvioidaan lähi-infrapunavalon etenemistä ihmisen aivoissa uudenlaisella menetelmällä. Kehitetyllä multimodaalisella mittausympäristöllä on tavoitteena antaa lääketieteen alan tutkijoille, erityisesti neurologeille, käyttöön mittausmenetelmiä, joiden avulla voidaan tutkia ihmisen aivojen ja kehon välisiä toimintoja aiempaa kattavammin. Laitekokonaisuudella on tutkittu jo yli 70:tä henkilöä. Näissä mittauksissa on tutkittu mm. veren happitasojen hitaita vaihteluja ihmisen aivojen ollessa lepotilassa, ns. resting state -tilassa
Frangou, Polytimi. "Inhibitory mechanisms for visual learning in the human brain." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/280767.
Full textRutter, Allison. "An NMR study of human brain tumours: Phosphorus chemical shift imaging in vivo and high resolution proton spectroscopy of biopsy samples." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7681.
Full textCorwin, Frank. "Characterization of a Blast Wave Device and Blast Wave Induced Traumatic Brain Injury in a Rat Model by Magnetic Resonance Imaging and Spectroscopy." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2403.
Full textMorken, Tora Sund. "Brain development and metabolism after hypoxia-ischemia and varying oxygen levels in the neonatal rat studied with 13C-MR spectroscopy and multimodal MR imaging." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for laboratoriemedisin, barne- og kvinnesykdommer, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-23712.
Full textOjha, Navdeep. "Imaging of tissue injury-repair addressing the significance of oxygen and its derivatives." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1196204993.
Full textMartel, Dimitri. "Spectroscopie 2D de corrélation quantitative : Méthode de quantification, études expérimentales et applications in vivo." Thesis, Lyon, INSA, 2015. http://www.theses.fr/2015ISAL0004/document.
Full textIn in vivo Magnetic Resonance Spectroscopy (MRS), the main methods used allow metabolite concentration quantification using signals having one spectral dimension. This work focuses on the development of in vivo two dimensional correlated MRS in order to increase spectral resolution and quantification precision. The first axis is about the development of a method based on a 2D localized correlation MRS (L-COSY) for brain metabolite exploration. The L-COSY is implemented and studied on a small animal scanner. A dedicated quantification procedure operating in the acquisition domain is described. This latter is based on 1) a strong prior knowledge obtained by quantum mechanically simulate the effect of sequence on metabolite spin systems 2) a model function taking into account the relaxation weighting 3) constraints on the relaxation term linked to the field inhomogeneity effects which are assumed to act the same way on all the spins. Results are given experimentally using metabolites phantoms and through a comparison to other existing 2D MRS method, namely the J-resolved MRS (with the JPRESS sequence) using the Cramer Rao Lower Bounds (CRBs) theory. Although its inherent loss of signal to noise ratio is a disadvantage compared to J-PRESS, L-COSY quantification shows theoretically competitive relative CRBs, and even smaller CRBs for some coupled metabolites (e.g Glutamine or GABA), for an acquisition time similar to JPRESS. Second axis is about the adaptation of the 2D correlation MRS for the in vivo lipid metabolism study in the liver and subcutaneous adipose tissues of obese mice at 7T. This application shows the feasibility of 2D correlated MRS to be acquired on a moving organ and its quantitative relevance for triglyceride quantification and characterization in fatty liver and subcutaneous tissue
Dahlqvist, Leinhard Olof. "Quantitative Magnetic Resonance in Diffuse Neurological and Liver Disease." Doctoral thesis, Linköping : Department of Medical and Health Sciences, Linköping University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54728.
Full textSchmitz, Birte [Verfasser], Xiaoqi [Akademischer Betreuer] Ding, and Karin [Akademischer Betreuer] Weißenborn. "Investigation of metabolic and microstructural alterations in human brain under physiological and pathological conditions by using magnetic resonance imaging and 1H and 31P magnetic resonance spectroscopy / Birte Schmitz ; Akademische Betreuer: Xiaoqi Ding, Karin Weißenborn ; Institut für Diagnostische und Interventionelle Neuroradiologie." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2020. http://d-nb.info/1225413656/34.
Full textFellah, Slim. "Exploration par IRM multimodale des tumeurs cérébrales de l'enfant et de l'adulte. : Lésions épileptogènes, tumeurs oligodendrogliales et glioblastome." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5035.
Full textConventional MRI is considered as the gold standard method for the non-invasive diagnosis, pretherapeutic assessment and follow-up of brain tumors in adults and in children. However, due to its lack of specificity for both differential diagnosis and evaluation of the response to treatment, several MR modalities are now added to the conventional exam in order to refine the exploration of these tumors. The use of a single modality is however not yet sufficient to establish an accurate diagnosis or prognosis for brain tumors. For this reason, we were interested in the combination of data from different MR modalities in order to obtain a better characterization of these neoplasms. In this context, we used multimodal MRI to investigate 1) pediatric epileptogenic tumors, for which it is crucial to establish a preoperative diagnosis in order to make appropriate surgical and therapeutic decisions; 2) oligodendroglial tumors in adults, hardly distinguishable and which therapeutic decisions are mainly based on the determination of the tumoral grade and molecular profile; and 3) the response of glioblastoma to anti-angiogenic treatments. Through this work, we have shown that the association of different imaging modalities provides a significant contribution to the differential pre-therapeutic diagnosis of epileptogenic brain lesions in children and also of oligodendroglial tumors in adults as well as a support for the early assessment of tumoral response to anti-angiogenic therapies
Bruhn, Harald. "Untersuchungen physiologischer und pathophysiologischer Stoffwechselzustände und Hirnfunktionen des Menschen mit Hilfe neuer methodischer Entwicklungen zur ortsaufgelösten Magnetresonanz-Spektroskopie und funktionellen Magnetresonanz-Tomografie." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13769.
Full textThis work has two main parts that summarize pioneering contributions to localized magnetic resonance spectroscopy (MRS), functional magnetic resonance tomography (fMRI), and the introduction of these modalities into diagnostic medicine. First, it is described how biochemical metabolites such as the intracellular pools of N-acetylaspartate, creatine and phosphocreatine, choline-containing compounds, and lactate have been made accessible to noninvasive detection and to the quantification of their respective concentrations in vivo in defined cerebral regions of healthy subjects by utilizing the stimulated echo-acquisition mode (STEAM) localization technique. Then it is shown that further development of the robust STEAM technique to short echo times not only increased the signal-to-noise of the measurement, thereby providing access to smaller volumes-of-interest, but also allowed for the detection and quantification of additional metabolites such as myo- and scyllo-inositol, glutamate, glutamine, N-acetylaspartylglutamate, and glucose. Thus, together with the adoption of the linear combination method (LCModel) for concentration calculation, this method has set the standard for spectroscopic state-of-the-art in the field well over the last decade. Moreover, pioneering achievements have been highlighted with regard to applications in brain diseases of focal and generalized nature. Pertinent applications of localized single-volume STEAM proton spectroscopy to circumscribed processes include cerebral tumors, cerebral infarction, multiple sclerosis plaques, and other inflammatory and degenerative lesions. Also localized STEAM phosphorus spectroscopy and non-cerebral applications including localized proton spectroscopy of skeletal muscle and kidney largely depend on the short-echo time STEAM technique. In addition, applications in generalized disorders have been explored, which include inborn errors of metabolism in childhood, such as mitochondrial and lysosomal defects, metabolic disturbances in diabetes mellitus and liver cirrhosis, and psychiatric diseases such as Alzheimer's dementia. The further utilization of these novel methods in clinical diagnostics will heavily depend on quality measures and the mastering of a true quantification procedure as demonstrated. Second, this work summarizes achievements made in developing and applying both proton MR spectroscopy and susceptibility-sensitized MR imaging to measure physiologic brain activation using visual stimulation as a model. Whereas metabolic stress, brought upon the bioenergetic steady state in the responding striate cortex, was detected by decreased parenchymal glucose and increased lactate using time-resolved spectroscopy, mapping the extent of parenchymal activation was found to be possible by increases of image intensity in T2*-weighted FLASH MRI made sensitive to concomitant decreases of paramagnetic deoxyhemoglobin in the functionally active tissue. Finally, studies are described, which show the sensitivity of this endogenous, susceptibility-sensitive contrast, now generally known as BOLD effect, to various drugs or pharmacologic stimuli acting either directly or indirectly on vascular receptors. These latter studies open up again a new field of imaging, dubbed pharmacologic MRI.
Perrillat-Mercerot, Angélique. "Modélisation et étude du métabolisme énergétique cérébral. Applications à l'imagerie des gliomes diffus de bas grade." Thesis, Poitiers, 2019. http://www.theses.fr/2019POIT2285/document.
Full textEverything that lives is born, eats, reproduces and dies. For the brain, the question is more complex because neurons have to survive and to support brain activity. Energy management is also particular because brain cells evolve together with no competition. Thanks to medical imaging, we know that neurons do not consume only glucose. They can use others energetic substrates such as lactate and glutamate as a power source.When a tumor appears, it changes the energetic metabolism to survive and support its own growth. In particular, cancer cells like to consume lactate. They also choose their favorite substrate based on the available oxygen. Modeling of energy substrates is useful to describe and predict energetic kinetics and changes. Mathematical models could get with clinical and medical results to describe, explain or predict low grade glioma dynamics. They can help to characterize and quantify a tumor evolution, then leading to improve their therapeutical management. Exchanges between mathematics and MRI (and MRS) enable to get accurate data and to build suitable mathematical models.This thesis deals with several approaches of substrates dynamics in healthy and gliomatous brains. These researches are based on systems of equations. We model local lactate exchanges (ODE, fast-slow systems), global substrates exchanges (ODE), glutamate/glutamine cycle (RDE) and local lactate exchanges in higher dimensions (PDE). We describe, analyze and give simulations of these models. Simulations are fitted on patient MRI data or literature data. Energy is necessary to live. But if your neighbor consumes a part of your resources, can you still survive ?
Tutto ciò che vive nasce, si nutre, si riproduce e muore. Per il cervello, la questione è più complessa perché i neuroni devono sopravvivere e sostenere l'attività cerebrale. La gestione energetica cerebrale è particolare anche perché le cellule cerebrali evolvono insieme, senza concorrenza. Inoltre, grazie alle immagini mediche, sappiamo che i neuroni non consumano solo del glucosio ma usano altri substrati energetici come il lattato o il glutammato.Quando un tumore si stabilisce, cambia il metabolismo energetico del cervello per sopravvivere e sostenere la propria crescita. In particolare, cellule tumorali consumano del lattato e scelgono il loro substrato preferito basandosi all'ossigeno disponibile.La matematica, e in particolare l'elaborazione di modelli matematici può aiutarci a ottimizzare i dati disponibili, che possono essere, di volta in volta, delle proprietà cellulare o delle lastre MRI o MRS. La modellizzazione dei substrati energetici potrebbe descrivere, spiegare o prevedere le dinamiche energetiche nel cervello.Questa tesi tratta di diversi approcci della dinamica dei substrati nei cervelli sani e gliomatosi. Queste ricerche si basano su sistemi di equazioni. Modellizziamo scambi locali di lattato (ODE, sistemi fast-slow), scambi globali di substrati (ODE), ciclo glutammato/glutammina (RDE) e scambi locali di lattato in dimensioni superiori (PDE). Descriviamo, analizziamo e diamo simulazioni di questi modelli. Le simulazioni sono adeguate su dati MRI paziente o dati di letteratura.Per vivere, l’energia è una necessità. Ma se i Suoi vicini consumassero le Sue risorse, riuscirebbe ancora a sopravvivere ?
Sapey-Triomphe, Laurie-Anne. "Inférence et apprentissage perceptifs dans l’autisme : une approche comportementale et neurophysiologique." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1130/document.
Full textHow we perceive our environment relies both on sensory information and on our priors or expectations. Within the Baysian framework, these priors capture the underlying statistical regularities of our environment and allow inferring sensation causes. Recently, Bayesian brain theories suggested that autistic symptoms could arise from an atypical weighting of sensory information and priors. Autism spectrum disorders (ASD) is characterized defined by difficulties in social interactions, by restricted and repetitive patterns of behaviors, and by an atypical sensory perception.This thesis aims at characterizing perceptual inference and learning in ASD, and studies sensory sensitivity and prior learning. This was investigated using behavioral tasks, computational models, questionnaires, functional magnetic resonance imaging and magnetic resonance spectroscopy in adults with or without ASD. Sensory profiles in people with high autism spectrum quotients were first refined, using a questionnaire that we validated in French. The study of perceptual learning strategies then revealed that subjects with ASD were less inclined to spontaneously use a learning style enabling generalization. The implicit learning of priors was explored and showed that subjects with ASD were able to build up a prior but had difficulties adjusting it in changing contexts. Finally, the investigation of the neurophysiological correlates and molecular underpinnings of a similar task showed that perceptual decisions biased by priors relied on a distinct neural network in ASD, and was not related to the same modulation by the glutamate/GABA ratio.The overall results shed light on an atypical learning and weighting of priors in ASD, resulting in an abnormal perceptual inference. A Bayesian approach could help characterizing ASD and could contribute to ASD diagnosis and care
Henninger, Nils. "Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/900.
Full textWegrzyk, Jennifer. "Wide-pulse, high-frequency electrical stimulation" in humans : Combined investigations of neural and muscular function using electrophysiological and nuclear magnetic resonance techniques." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4080.
Full textConventional neuromuscular electrical stimulation (CONV) is delivered via surface electrodes at short pulse duration (< 400 μs), low frequencies (≤ 50 Hz) and high current intensities. The motor unit recruitment pattern of CONV, however, is different from the pattern of voluntary contractions (VOL) and leads to a hastened onset of muscle fatigue. The use of wide-pulses (1ms), high frequencies (100 Hz) (WPHF) and low current intensities might approach the natural activation pattern of VOL by enhancing the neural contribution to force production. Previous studies investigating WPHF reported progressive and unexpected force increments ("Extra Forces") despite a constant stimulation intensity which might reflect the more pronounced activation of sensory pathways within the central nervous system. The objective of this thesis was to investigate this "Extra Force" (EF) phenomenon and to evaluate the efficiency of WPHF (1 ms pulse duration at 100 Hz) in terms of metabolic demand and neural contribution to force production in comparison to CONV NMES (0.05 ms pulse duration at 25 Hz) and VOL. Our experiments comprised electrophysiological (EMG) and nuclear magnetic resonance techniques (31P spectroscopy of the muscle, functional imaging of the brain). The findings should be considered in future studies investigating the potential of NMES in a clinical context as a treatment for neuromuscular pathologies
Bojan, Jelača. "Dijagnostički značaj i pouzdanost stereotaksične biopsije u tretmanu pacijenata sa tumorima mozga." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107296&source=NDLTD&language=en.
Full textIntroduction: The implementation of numerous neuroradiological techniques has significantly influenced the way and the efficiency in which the diagnosis of brain tumor is established. Based on non-invasive imaging data, a differential diagnosis can be made, but no neuroradiological method has been established so far, which can finally make a definitive diagnosis. Stereotactic biopsy is a neurosurgical procedure that can provide a representative sample of any intracranial tumor in order to performe histopathological and other specific examinations, and to set the exact diagnosis and then apply adequate treatment, but without significantly impairing the integrity and function of brain tissue. Objective: The aim of this study is to determine the diagnostic value of stereotactic biopsy and ability of providing the representative tissue in order to establish a pathohistological diagnosis in patients with brain tumors. Also, the aim is to determine the type and frequency of possible complications of the procedure itself and the correlation between the pathohistological findings obtained and the results of the conducted neuroradiological examinations. Materials and methods: This research was clinical, prospective and included a total of 50 patients who were hospitalized at the Clinical Center of Vojvodina, from September 2016 to January 2018, due to diagnosed brain tumor for which the stereotactic biopsy is indicated. In all patients magnetic resonance (MRI) examination of the head was used to determine morphological characteristics and assesse the nature of the brain tumor tissue, and in a total of 25 patients MR spectroscopy was additionally made with the goal of determining the biochemical profile and additional tissue assessment and characterization. After detailed oncological assessment, completed laboratory and radiological diagnostics, a CT guided framebased stereotactic biopsy was performed for the purpose of sampling tumor tissue for pathohistological analysis. During the research, the success rate of biopsy in providing the representative tissue and establishing the diagnosis was performed by a pathologist, and after the procedure, a clinical and a control head CT examination was used to review the rate of complications. Results: The results obtained showed that focal neurological deficit and psychoorganic syndrome were the most common clinical symptoms and signs in this study. According to MRI, the most common were diffuse brain tumors with 36% of the sample, then solitary with 34% and multifocal with 20%, followed by multicentric tumors representing 10% of the study sample. Also, based on MRI and MRS findings, approximately 80% of tumors are estimated to be most likely of glial origin. In 95.9% of cases, a complete pathohistological (PH) diagnosis was established. The unchanged neurological status was observed in 92% of patients after biopsy, and 3 patients (6%) developed a transient neurological deficit, while only one patient (2%) developed a permanent neurological deficit. The total morbidity associated with the procedure is therefore 2%, and no deaths (mortality 0%) related to the procedure during the study is recorded. Conclusion: Stereotactic biopsy is highly reliable procedure with a small number of complications and a low morbidity and mortality rate, which allows us to acquire the representative sample of brain tumor tissue and to establish a pathohistological diagnosis. Intraoperative PH analysis of acquired tissue samples further enhances the sampling performance and the setting of definitive PH diagnosis. Modern neuroradiological modalities have a high specificity in distinguishing the biological nature of brain tumors, but they still can not be used independently of the pathohistological analysis of the tissue sample.
Cohen, Ouri. "In-Vivo Three Dimensional Proton Hadamard Spectroscopic Imaging in the Human Brain." Thesis, 2013. https://doi.org/10.7916/D8639X3V.
Full textOsorio, Joseph Anthony. "Development of improved 1H magnetic resonance spectroscopic imaging techniques for brain tumor patients." Diss., 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3274655.
Full textChen, Yue. "Three dimensional localization and [1]H magnetic resonance spectroscopic imaging of an animal model of epilepsy /." 1998. http://wwwlib.umi.com/dissertations/fullcit/9824274.
Full text(7026797), Nicole L. Vike. "Spectroscopic Investigation of a Novel Traumatic Brain Injury Biomarker and Analysis of Neurometabolic Changes in Youth American Football Athletes." Thesis, 2019.
Find full textAndrews-Shigaki, Brian C. "Analysis of segmentation methods for partial volume correction in magnetic resonance spectroscopy voxels." Thesis, 2007. http://hdl.handle.net/10125/20420.
Full textHe, Xuanzi. "Edited magnetic resonance spectroscopy detects an age-related decline in monkey brain GABA levels." Thesis, 2015. https://hdl.handle.net/2144/15623.
Full textRakhshani, Fatmehsari Younes. "Designing and Implementing a Portable Near-Infrared Imaging System for Monitoring of Human’s Functional Brain Activity." 2015. http://hdl.handle.net/1993/30245.
Full textGebhart, Steven Charles. "Liquid-crystal tunable filter spectral imaging for discrimination between normal and neoplastic tissues in the brain." Diss., 2006. http://etd.library.vanderbilt.edu/ETD-db/available/etd-11272006-131802/.
Full textPei-YiLin and 林佩儀. "Optical Brain Imaging of Stroke Patients Using Near Infrared Spectroscopy (NIRS) during Bilateral Pedaling." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/91861538811987597377.
Full textWei, Mian. "Development of advanced Raman microscopy methods to interrogate the brain." Thesis, 2021. https://doi.org/10.7916/d8-adm1-vq24.
Full textAyyalasomayajula, Kalyan Ram. "Development and Validation of Analytical Models for Diffuse Fluorescence Spectroscopy/Imaging in Regular Geometries." Thesis, 2013. http://hdl.handle.net/2005/3275.
Full textJuchem, Christoph [Verfasser]. "1H MR spectroscopy and chemical shift imaging of the in vivo brain at 7 Tesla / vorgelegt von Christoph Juchem." 2006. http://d-nb.info/983668671/34.
Full textAuger, Héloïse. "Techniques de spectroscopie proche infrarouge appliquées à la quantification de paramètres hémodynamiques." Thèse, 2016. http://hdl.handle.net/1866/18896.
Full textThis master’s thesis is separated in two phases, both focused on near infrared spectroscopy for the quantification of hemodynamic parameters. NIRS is based on the measure of absorption (μa) and scattering (μs’) coefficients of tissues in order to recover the oxy- and deoxyhemoglobin concentrations in the blood. Its results are based on the photon propagation in tissue at different near-infrared wavelengths. The first NIRS system used during my studies is a time-resolved spectroscopy system. This device allowed us to retrieve absolute hemoglobin concentrations using a headband placed over the subject’s skin and centered on their forehead. The data analysis model which we used allowed us to separate extra-cerebral and cerebral contributions of the signal. This method yielded quantitative absolute measures of cerebral oxygen saturation as opposed to the traditional homogenous model where the signal is contaminated by superficial layers. A study on cerebral hemodynamic changes in young adults during exercise was conducted, and the published article detailing its results is transcribed in Chapter 2. Chapter 3 includes a review of this study and discusses potential future works. The second part of my research consisted in an industrial internship during the summer of 2016. Under the supervision of Dennis Hueber, Ph. D., and Beniamino Barbieri, Ph. D., I have worked on a NIRS device manufactured by ISS Inc., a prototype of which is currently in the laboratory of my supervisor Mathieu Dehaes, Ph. D. This device combines two NIRS modalities: frequency-domain NIRS and diffuse correlation spectroscopy. Chapter 4 details the work I have performed at ISS and the results of my research and analysis.
Chamard, Emilie. "Modifications neurométaboliques et microstructurales à la suite d'une commotion cérébrale chez les athlètes féminines." Thèse, 2016. http://hdl.handle.net/1866/16041.
Full textBeausoleil, Thierry P. "Techniques de spectroscopie proche infrarouge et analyses dans le plan temps-fréquence appliquées à l’évaluation hémodynamique du très grand prématuré." Thèse, 2017. http://hdl.handle.net/1866/20527.
Full textKundu, Madan Gopal. "Advanced Modeling of Longitudinal Spectroscopy Data." Thesis, 2014. http://hdl.handle.net/1805/5454.
Full textMagnetic resonance (MR) spectroscopy is a neuroimaging technique. It is widely used to quantify the concentration of important metabolites in a brain tissue. Imbalance in concentration of brain metabolites has been found to be associated with development of neurological impairment. There has been increasing trend of using MR spectroscopy as a diagnosis tool for neurological disorders. We established statistical methodology to analyze data obtained from the MR spectroscopy in the context of the HIV associated neurological disorder. First, we have developed novel methodology to study the association of marker of neurological disorder with MR spectrum from brain and how this association evolves with time. The entire problem fits into the framework of scalar-on-function regression model with individual spectrum being the functional predictor. We have extended one of the existing cross-sectional scalar-on-function regression techniques to longitudinal set-up. Advantage of proposed method includes: 1) ability to model flexible time-varying association between response and functional predictor and (2) ability to incorporate prior information. Second part of research attempts to study the influence of the clinical and demographic factors on the progression of brain metabolites over time. In order to understand the influence of these factors in fully non-parametric way, we proposed LongCART algorithm to construct regression tree with longitudinal data. Such a regression tree helps to identify smaller subpopulations (characterized by baseline factors) with differential longitudinal profile and hence helps us to identify influence of baseline factors. Advantage of LongCART algorithm includes: (1) it maintains of type-I error in determining best split, (2) substantially reduces computation time and (2) applicable even observations are taken at subject-specific time-points. Finally, we carried out an in-depth analysis of longitudinal changes in the brain metabolite concentrations in three brain regions, namely, white matter, gray matter and basal ganglia in chronically infected HIV patients enrolled in HIV Neuroimaging Consortium study. We studied the influence of important baseline factors (clinical and demographic) on these longitudinal profiles of brain metabolites using LongCART algorithm in order to identify subgroup of patients at higher risk of neurological impairment.
Partial research support was provided by the National Institutes of Health grants U01-MH083545, R01-CA126205 and U01-CA086368