Academic literature on the topic 'Brain research; Immunocytochemistry; Neuroscience'

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Journal articles on the topic "Brain research; Immunocytochemistry; Neuroscience"

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Khachaturian, Henry, Michael E. Lewis, Suzanne N. Haber, Richard A. Houghten, Huda Akil, and Stanley J. Watson. "Prodynorphin peptide immunocytochemistry in rhesus monkey brain." Peptides 6 (January 1985): 155–66. http://dx.doi.org/10.1016/0196-9781(85)90149-4.

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Braas, KM, AC Newby, VS Wilson, and SH Snyder. "Adenosine-containing neurons in the brain localized by immunocytochemistry." Journal of Neuroscience 6, no. 7 (July 1, 1986): 1952–61. http://dx.doi.org/10.1523/jneurosci.06-07-01952.1986.

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Hainfellner, Johannes A., Pawel P. Liberski, Don C. Guiroy, Larisa Cervénaková, Paul Brown, D. Carleton Gajdusek, and Herbert Budka. "Pathology and Immunocytochemistry of a Kuru Brain." Brain Pathology 7, no. 1 (January 1997): 547–53. http://dx.doi.org/10.1111/j.1750-3639.1997.tb01072.x.

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Wendt, Beatrice, and Uwe Homberg. "Immunocytochemistry of dopamine in the brain of the locustSchistocerca gregaria." Journal of Comparative Neurology 321, no. 3 (July 15, 1992): 387–403. http://dx.doi.org/10.1002/cne.903210307.

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Dani, J. W., D. M. Armstrong, and L. I. Benowitz. "Mapping the development of the rat brain by GAP-43 immunocytochemistry." Neuroscience 40, no. 1 (January 1991): 277–87. http://dx.doi.org/10.1016/0306-4522(91)90190-y.

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Song, David D., Jean Rossier, and Richard E. Harlan. "Comparison of synenkephalin and methionine enkephalin immunocytochemistry in rat brain." Peptides 10, no. 6 (November 1989): 1239–46. http://dx.doi.org/10.1016/0196-9781(89)90018-1.

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Shiurba, Robert A., Edward T. Spooner, Koichi Ishiguro, Miho Takahashi, Rie Yoshida, Timothy R. Wheelock, Kazutomo Imahori, Anne M. Cataldo, and Ralph A. Nixon. "Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections." Brain Research Protocols 2, no. 2 (January 1998): 109–19. http://dx.doi.org/10.1016/s1385-299x(97)00029-9.

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Wouterlood, F. G., Y. M. H. F. Sauren, and H. W. M. Steinbusch. "Histaminergic neurons in the rat brain: Correlative immunocytochemistry, golgi impregnation, and electron microscopy." Journal of Comparative Neurology 252, no. 2 (October 8, 1986): 227–44. http://dx.doi.org/10.1002/cne.902520207.

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Larue, David T., and Jeffrey A. Winer. "Postembedding immunocytochemistry of large sections of brain tissue: an improved flat embedding technique." Journal of Neuroscience Methods 68, no. 1 (September 1996): 125–32. http://dx.doi.org/10.1016/0165-0270(96)00048-9.

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Barnes, Kathleen, Anthony J. Turner, and A. John Kenny. "Electronmicroscopic immunocytochemistry of pig brain shows that endopeptidase-24.11 is localized in neuronal membranes." Neuroscience Letters 94, no. 1-2 (November 1988): 64–69. http://dx.doi.org/10.1016/0304-3940(88)90271-6.

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Dissertations / Theses on the topic "Brain research; Immunocytochemistry; Neuroscience"

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Hanley, Jason James. "Synaptology of major afferents to the neostriatal sub-compartments in the rat." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390443.

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Freeman, Tobe. "Mechanisms of binocular integration and their development in the cat primary visual cortex." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267925.

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Hölscher, Christian. "Behavioural and pharmacological studies of memory formation in the domestic chick, Gallus domesticus." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385848.

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Best, Nicholas James. "Paravalbumin-immunoreactive hippocampal neurons in an animal model of epilepsy." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296242.

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Burns, Lindsay H. "Functional interactions of limbic afferents to the striatum and mesolimbic dopamine in reward-related processes." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239196.

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Barrantes, Georgina Elida. "Nicotinic acetylcholine receptor subtypes in primary cultures of hippocampal neurons." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386845.

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Allan, Stuart McRae. "Excitatory amino acid-mediated modulation of synaptic transmission in rat hippocampal slices." Thesis, University of Aberdeen, 1993. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU540765.

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The whole-cell patch-clamp technique was established in the laboratory in order to investigate the modulation of excitatory amino acid-mediated synaptic transmission in the rat hippocampal slice. Following the successful development of the technique the basic properties of excitatory amino acid-mediated synaptic transmission in the CA3-CA1 pathway were studied. Stimulation of the SCCFs (Schaffer collateral-commissural fibres) under conditions in which the inhibitory transmission was blocked resulted in a compound EPSC (excitatory postsynaptic current) mediated by AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartic acid) receptors. Application of a brief high-frequency stimulus to the SCCFs resulted in a long-lasting potentiation of the EPSC. Various compounds were applied to the slice to establish whether tetanus-induced potentiation could be mimicked pharmacologically. No potentiation was observed with perfusion of the ionotropic glutamate-receptor agonists L-glutamate, NMDA or AMPA, the latter two producing a transient depression of the EPSC. Following this a series of experiments were performed that investigated the consequences of mGluR (metabotropic glutamate receptor) activation. Perfusion with the selective agonist 1S,3R-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) resulted in a small depression of both the compound EPSC and the isolated NMDA receptor-mediated EPSC. In the presence of AA (arachidonic acid (10M)), 1S,3R-ACPD produced a slight potentiation of the response that was not blocked by the NMDA receptor antagonist D-AP5 (D-(-)-2-amino-5-phosphonopentanoic acid). The co-application of 1S,3R-ACPD and NMDA also produced a slight enhancement of the EPSC, as did AA when applied alone. These findings are consistent with an involvement of mGluRs in the induction of LTP, when activated in the presence of AA.
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O'Brien, John Anthony. "Novel applications of a modified gene gun : implications for new research in neuroscience." Thesis, Anglia Ruskin University, 2012. http://arro.anglia.ac.uk/303408/.

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The original Bio-Rad gene gun was unable to transfect acute or organotypic brain slices, as the amount of helium gas used, the distance for the gold-coated microcarriers to travel to target area were not optimised for fragile tissues, such as the brain. Typically, tissues were severely damaged by a helium shock wave and only a few cells were transfected. It was essential to improve gene gun accuracy by restricting the gold particles from being propelled superficially over a wide area. It was also necessary to increase the amount of DNA or dye delivery into intact tissues. Furthermore, for the gene gun to perform successfully on brain slices the helium gas pressure had to be lowered thereby reducing the degree of cell damage incurred during a biolistic delivery. Without knowing it at the time, the modified gene gun had worked particularly well on a variety of other fragile tissues, and not just the brain. However, the modified gun was not optimised for cultured cells as other transfection methods were available. A particularly notable point of this work was the successful labelling of individual Purkinje dendritic spines from live nerve cells in the cerebellum region of the brain. Biolistic images of Purkinje cells show that the distribution of dendritic spines are not random (O’Brien and Unwin, 2006). Spines were shown to grow in elaborate regular linear arrays, that trace short-pitch helical paths around the dendrites. It was apparent that the spines are arranged to maximize the probability that the dendritic arbour would interact with any afferent axon. This was an important discovery as there has been much debate as to how spines develop on a dendritic shaft. There are three general views to this question, each proposing a theory describing a model for spinogenesis. Classification of the three models in relation to our findings is described in chapter six of this thesis. The Investigation of spine morphology by biolistics was further optimized; gold particles were reduced from a micrometre to forty nanometres (O’Brien and Lummis, 2011), demonstrating that it is possible to use gold-coated DNA nanoparticles of this size to transfect tissue revealing exquisite structural detail. It was possible to observe boutons making synaptic contacts with the pyramidal nerve spines in the hippocampal region of the brain. The findings so far have shown spines from the pyramidal shaft are similar to the spines in the cerebellum, forming regular linear arrays. Recent studies had linked defects in the function of presynaptic boutons to the etiology of several neurodevelopment and neurodegenerative diseases, including autism and Alzheimer’s disease. Our discovery could help to understand why there are abnormalities in dendritic spines which are associated with pathological conditions characterized by cognitive decline, such as mental retardation, Alzheimer’s, stroke and schizophrenia (Yuste and Bonhoeffer, 2001). This thesis provides a synthesis of knowledge about biolistic technology. It is presented as a narrative from improving the gene gun transfection efficiency in brain slices to the development of nano-biolistics. The delivery of DNA and fluorescent dyes into living cells by biolistic delivery should enable a detailed map of the anatomical connections between individual cells and groups of cells to be constructed, providing a “wiring diagram” of connections. The implications of this are discussed in Chapter twelve. The original Bio-Rad gene gun was unable to transfect acute or organotypic brain slices, as the amount of helium gas used, the distance for the gold-coated microcarriers to travel to target area were not optimised for fragile tissues, such as the brain. Typically, tissues were severely damaged by a helium shock wave and only a few cells were transfected. It was essential to improve gene gun accuracy by restricting the gold particles from being propelled superficially over a wide area. It was also necessary to increase the amount of DNA or dye delivery into intact tissues. Furthermore, for the gene gun to perform successfully on brain slices the helium gas pressure had to be lowered thereby reducing the degree of cell damage incurred during a biolistic delivery. Without knowing it at the time, the modified gene gun had worked particularly well on a variety of other fragile tissues, and not just the brain. However, the modified gun was not optimised for cultured cells as other transfection methods were available. A particularly notable point of this work was the successful labelling of individual Purkinje dendritic spines from live nerve cells in the cerebellum region of the brain. Biolistic images of Purkinje cells show that the distribution of dendritic spines are not random (O’Brien and Unwin, 2006). Spines were shown to grow in elaborate regular linear arrays, that trace short-pitch helical paths around the dendrites. It was apparent that the spines are arranged to maximize the probability that the dendritic arbour would interact with any afferent axon. This was an important discovery as there has been much debate as to how spines develop on a dendritic shaft. There are three general views to this question, each proposing a theory describing a model for spinogenesis. Classification of the three models in relation to our findings is described in chapter six of this thesis. The Investigation of spine morphology by biolistics was further optimized; gold particles were reduced from a micrometre to forty nanometres (O’Brien and Lummis, 2011), demonstrating that it is possible to use gold-coated DNA nanoparticles of this size to transfect tissue revealing exquisite structural detail. It was possible to observe boutons making synaptic contacts with the pyramidal nerve spines in the hippocampal region of the brain. The findings so far have shown spines from the pyramidal shaft are similar to the spines in the cerebellum, forming regular linear arrays. Recent studies had linked defects in the function of presynaptic boutons to the etiology of several neurodevelopment and neurodegenerative diseases, including autism and Alzheimer’s disease. Our discovery could help to understand why there are abnormalities in dendritic spines which are associated with pathological conditions characterized by cognitive decline, such as mental retardation, Alzheimer’s, stroke and schizophrenia (Yuste and Bonhoeffer, 2001). This thesis provides a synthesis of knowledge about biolistic technology. It is presented as a narrative from improving the gene gun transfection efficiency in brain slices to the development of nano-biolistics. The delivery of DNA and fluorescent dyes into living cells by biolistic delivery should enable a detailed map of the anatomical connections between individual cells and groups of cells to be constructed, providing a “wiring diagram” of connections. The implications of this are discussed in Chapter twelve.
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Peden, Carmen Elena Socarras. "Characterization of the immune response to recombinant adeno-associated viral vectors in the brain." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004403.

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Thesis (Ph.D.)--University of Florida, 2004.
Typescript. Title from title page of source document. Document formatted into pages; contains 134 pages. Includes Vita. Includes bibliographical references.
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Habroun, Stacy Star. "Effects of Food Consumption on Cell Proliferation in the Brain of Python regius." DigitalCommons@CalPoly, 2017. https://digitalcommons.calpoly.edu/theses/1763.

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Neurogenesis is an important and vastly under-explored area in reptiles. While the ability to generate new brain cells in the adult mammalian brain is limited, reptiles are able to regenerate large populations of neuronal cells. Pythons exhibit a characteristic specific dynamic action (SDA) response after food intake with an increase in metabolic rate that facilitates processing the meal. Associated with this change in SDA, pythons (Python spp.) also exhibit impressive plasticity in their digestive and cardiovascular physiology due to the sheer magnitude of the increase in organ growth that occurs after a meal to speed digestion, absorption, and assimilation of nutrients. While this systemic growth in response following food consumption is well documented, whether the python brain exhibits associated changes in cell proliferation following food consumption and digestion is currently unexplored. For this study, juvenile male ball pythons (Python regius) were used to test the hypothesis that postprandial neurogenesis is associated with food consumption. We used the thymidine analog 5-bromo-12’-deoxyuridine (BrdU) to quantify and compare cell proliferation in the brain of fasted snakes and at two time points: two days and six days after a meal, which span time periods of during and after SDA response, respectively. Quantification of BrdU-labeled cells in the ventricular regions relealed that – consistent with other reptile species – the retrobulbar and olfactory regions had the highest numbers of proliferating cells in the python brain, regardless of sampling time. Throughout the telencephalon, cell proliferation was significantly greater in the six-day post-feeding group, with no difference between the two-day post-feeding group and controls. Most other postprandial systemic plasticity occurs within a day or two after a meal and decreases thereafter; however, the brain displays a more delayed response, with a surge of cell proliferation after most of the digestion and absorption is complete. Our results support our hypothesis that food consumption does affect cell proliferation in the python brain, and indicates that the degree of increased proliferation is dependent on the time since feeding.
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Books on the topic "Brain research; Immunocytochemistry; Neuroscience"

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The neuroscience of psychotherapy: Healing the social brain. 2nd ed. New York: W.W. Norton & Co., 2010.

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Bob, Petr. Brain, Mind and Consciousness: Advances in Neuroscience Research. New York, NY: Springer Science+Business Media, LLC, 2011.

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Origins of neuroscience: A history of explorations into brain function. New York: Oxford University Press, 1994.

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Terra Nova Learning Systems (Firm). This is your brain: Teaching about neuroscience and addiction research. Arlington, Va: NSTA Press, 2012.

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Association, National Science Teachers, ed. This is your brain: Teaching about neuroscience and addiction research. Arlington, Va: NSTA Press, 2012.

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Introducing neuroeducational research: Neuroscience, education and the brain from contexts to practice. Abingdon, Oxon: Routledge, 2010.

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Brainwork: The neuroscience behind how we lead others. Bloomington, IN: Triple Nickel Press, 2012.

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Database, Institute of Medicine (U S. ). Committee on a. National Neural Circuitry. Mapping the brain and its functions: Integrating enabling technologies into neuroscience research. Washington, D.C: National Academy Press, 1991.

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Aging, National Institute on. Neuroscience and neuropsychology of aging program. [Bethesda, Md.]: National Institute on Aging, 2001.

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Addiction neuroethics: The ethics of addiction neuroscience research and treatment. London: Academic Press, 2012.

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Book chapters on the topic "Brain research; Immunocytochemistry; Neuroscience"

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Frahm, Jens, Peter Fransson, and Gunnar Krüger. "Magnetic Resonance Imaging of Human Brain Function." In Modern Techniques in Neuroscience Research, 1055–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-58552-4_38.

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Crivello, Fabrice, and Bernard Mazoyer. "Positron Emission Tomography of the Human Brain." In Modern Techniques in Neuroscience Research, 1083–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-58552-4_39.

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Blüml, Stefan, and Brian Ross. "Magnetic Resonance Spectroscopy of the Human Brain." In Modern Techniques in Neuroscience Research, 1099–148. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-58552-4_40.

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Brown, Rhonda Douglas. "Brain Development and Cognitive Neuroscience Research Methods." In Neuroscience of Mathematical Cognitive Development, 21–42. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-76409-2_2.

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Karpova, Nina N. "Analysis of Brain Epigenome: A Guide to Epigenetic Methods." In Epigenetic Methods in Neuroscience Research, 19–51. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2754-8_2.

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Sinha, Saurabh R., and Peter Saggau. "Optical Recording from Populations of Neurons in Brain Slices." In Modern Techniques in Neuroscience Research, 459–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-58552-4_16.

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Hollins, Sharon L., Fredrick R. Walker, and Murray J. Cairns. "Protocol for High-Throughput miRNA Profiling of the Rat Brain." In Epigenetic Methods in Neuroscience Research, 209–41. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2754-8_14.

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Kehr, Jan. "Monitoring Chemistry of Brain Microenvironment: Biosensors, Microdialysis and Related Techniques." In Modern Techniques in Neuroscience Research, 1149–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-58552-4_41.

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Sales, Amanda, Caroline Biojone, and Sâmia Joca. "Site-Specific Delivery of Epigenetic Modulating Drugs into the Rat Brain." In Epigenetic Methods in Neuroscience Research, 149–59. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2754-8_10.

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Silahtaroglu, Asli, Silke Herzer, and Björn Meister. "In Situ Detection of Neuron-Specific MicroRNAs in Frozen Brain Tissue." In Epigenetic Methods in Neuroscience Research, 195–208. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2754-8_13.

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Conference papers on the topic "Brain research; Immunocytochemistry; Neuroscience"

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Saveliev, Alexander. "ORIGIN OF CRINKLE BRAIN CORTEX. MICROSTRUCTURAL AND FUNCTIONAL RESEARCH." In XVI International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1232.sudak.ns2020-16/399-400.

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Mehtry, Vijay, Nizamuddin Parvez, Haque Nizamie, and Nityananda Pradhan. "Altered Brain Function as Evidenced by Electroencephalographic Power Spectral Analysis in Patients with Opioid Dependence." In Annual International Conference on Neuroscience and Neurobiology Research. Global Science & Technology Forum (GSTF), 2014. http://dx.doi.org/10.5176/2345-7813_cnn14.01.

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Proshchina, Alexandra, Anastasia Kharlamova, Dmitry Otlyga, and Sergey Saveliev. "THE COLLECTION OF HUMAN BRAIN DEVELOPMENTIN THE RESEARCH INSTITUTE OF HUMAN MORPHOLOGY." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2287.sudak.ns2021-17/310.

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Wilkosc, Monika, Agnieszka Szalkowska, Aleksander Araszkiewicz, Maria Skibinska, and Joanna Hauser. "ProBDNF (brain derived neurotrophic factor) serum level and cognitive function in healthy subjects from Polish population." In Annual International Conference on Neuroscience and Neurobiology Research. Global Science & Technology Forum (GSTF), 2014. http://dx.doi.org/10.5176/2345-7813_cnn14.08.

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Khotimah, Husnul, Mulyohadi Ali, Sutiman B. Sumitro, and M. Aris Widodo. "Sub-chronic exposure of Rotenone induce-synuclein aggregation and Apoptosis but decreased BDNF expression of Zebrafish Brain." In Annual International Conference on Neuroscience and Neurobiology Research. Global Science & Technology Forum (GSTF), 2014. http://dx.doi.org/10.5176/2345-7813_cnn14.06.

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"1st HBP Student Conference - Transdisciplinary Research Linking Neuroscience, Brain Medicine and Computer Science." In 1st HBP Student Conference - Transdisciplinary Research Linking Neuroscience, Brain Medicine and Computer Science. Frontiers Media SA, 2018. http://dx.doi.org/10.3389/978-2-88945-421-1.

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Van der Spiegel, Jan, Milin Zhang, and Xilin Liu. "The next-generation brain machine interface system for neuroscience research and neuroprosthetics development." In 2017 IEEE 12th International Conference on ASIC (ASICON). IEEE, 2017. http://dx.doi.org/10.1109/asicon.2017.8252507.

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Kawato, Mitsuo. "Japanese SRPBS for BMI research: Decoded neurofeedback as a causal tool in systems neuroscience." In 2013 International Winter Workshop on Brain-Computer Interface (BCI). IEEE, 2013. http://dx.doi.org/10.1109/iww-bci.2013.6506615.

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Shakova, Fatima, Yuliya Kirova, and Galina Romanova. "RESEARCH INTO THE MECHANISMS OF MULTI-TARGET EFFECTS OF NEUROPROTECTORS IN THE FOCAL BRAIN ISCHEMIA MODEL." In XVI International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2020. http://dx.doi.org/10.29003/m1340.sudak.ns2020-16/523-524.

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Cahyani Ratna Sari, Dwi, Soedjono Aswin, Rina Susilowati, Mawaddah Ar-Rochmah, Djoko Prakosa, Mansyur Romi, Untung Tranggono, and Nur Arfian. "Ethanol Extracts of Centella asiatica Leaf Improves Memory Performance in Rats after Chronic Stress via Reducing Nitric Oxide and Increasing Brain-Derived Neurotrophic Factor (BDNF) Concentration." In Annual International Conference on Neuroscience and Neurobiology Research. Global Science & Technology Forum (GSTF), 2013. http://dx.doi.org/10.5176/2345-7813_cnn13.09.

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Reports on the topic "Brain research; Immunocytochemistry; Neuroscience"

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Hannas, William, Huey-Meei Chang, Catherine Aiken, and Daniel Chou. China AI-Brain Research. Center for Security and Emerging Technology, September 2020. http://dx.doi.org/10.51593/20190033.

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Since 2016, China has engaged in a nationwide effort to "merge" AI and neuroscience research as a major part of its next-generation AI development program. This report explores China’s AI-brain program — identifying key players and organizations and recommending the creation of an open source S&T monitoring capability within the U.S. government.
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