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1
Batista, Sonia, Carolina Alves, Otília C. d’Almeida, Ana Afonso, Ricardo Félix-Morais, João Pereira, Carmo Macário, et al. "Disconnection as a mechanism for social cognition impairment in multiple sclerosis." Neurology 89, no. 1 (May 31, 2017): 38–45. http://dx.doi.org/10.1212/wnl.0000000000004060.
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Objective:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS).Methods:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education level. All participants underwent ToM testing (Eyes Test, Videos Test) and 3T brain MRI including conventional and diffusion tensor imaging sequences. Tract-based spatial statistics (TBSS) were applied for whole-brain voxel-wise analysis of fractional anisotropy (FA) and mean diffusivity (MD) on NAWM.Results:Patients with MS performed worse on both tasks of ToM compared to HC (Eyes Test 58.7 ± 13.8 vs 81.9 ± 10.4, p < 0.001, Hedges g −1.886; Videos Test 75.3 ± 9.3 vs 88.1 ± 7.1, p < 0.001, Hedges g −1.537). Performance on ToM tests was correlated with higher values of FA and lower values of MD across widespread white matter tracts. The largest effects (≥90% of voxels with statistical significance) for the Eyes Test were body and genu of corpus callosum, fornix, tapetum, uncinate fasciculus, and left inferior cerebellar peduncle, and for the Videos Test genu and splenium of corpus callosum, fornix, uncinate fasciculus, left tapetum, and right superior fronto-occipital fasciculus.Conclusions:These results indicate that a diffuse pattern of NAWM damage in MS contributes to social cognition impairment in the ToM domain, probably due to a mechanism of disconnection within the social brain network. Gray matter pathology is also expected to have an important role; thus further research is required to clarify the neural basis of social cognition impairment in MS.
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Adolphs, Ralph, Simon Baron-Cohen, and Daniel Tranel. "Impaired Recognition of Social Emotions following Amygdala Damage." Journal of Cognitive Neuroscience 14, no. 8 (November 1, 2002): 1264–74. http://dx.doi.org/10.1162/089892902760807258.
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Lesion, functional imaging, and single-unit studies in human and nonhuman animals have demonstrated a role for the amygdala in processing stimuli with emotional and social significance. We investigated the recognition of a wide variety of facial expressions, including basic emotions (e.g., happiness, anger) and social emotions (e.g., guilt, admiration, flirtatiousness). Prior findings with a standardized set of stimuli indicated that recognition of social emotions can be signaled by the eye region of the face and is disproportionately impaired in autism (Baron-Cohen, Wheelwright, & Jolliffe, 1997). To test the hypothesis that the recognition of social emotions depends on the amygdala, we administered the same stimuli to 30 subjects with unilateral amygdala damage (16 left, 14 right), 2 with bilateral amygdala damage, 47 brain-damaged controls, and 19 normal controls. Compared with controls, subjects with unilateral or bilateral amygdala damage were impaired when recognizing social emotions; moreover, they were more impaired in recognition of social emotions than in recognition of basic emotions, and, like previously described patients with autism, they were impaired also when asked to recognize social emotions from the eye region of the face alone. The findings suggest that the human amygdala is relatively specialized to process stimuli with complex social significance. The results also provide further support for the idea that some of the impairments in social cognition seen in patients with autism may result from dysfunction of the amygdala.
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Henry, Audrey, Ayman Tourbah, Marie-Pierre Chaunu, Lucien Rumbach, Michèle Montreuil, and Serge Bakchine. "Social Cognition Impairments in Relapsing-Remitting Multiple Sclerosis." Journal of the International Neuropsychological Society 17, no. 6 (October 7, 2011): 1122–31. http://dx.doi.org/10.1017/s1355617711001147.
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AbstractTheory of Mind (ToM) is the ability to attribute independent mental states to self and others to explain and predict behavior. Impairment of ToM is well established in developmental pathologies. In neurological populations, investigation of ToM is still rare but data suggest that ToM impairment could contribute to behavioral and social disturbances. In addition to neurological signs, multiple sclerosis (MS) presents with disorders of cognition and behavior directly related to brain damage. The aim of this study was to assess ToM abilities and recognition of facial emotional expression in adults with MS. We compared 64 patients with relapsing MS and 30 matched healthy controls on three levels of ToM tasks, a facial emotion recognition task, and a neuropsychological assessment. MS patients performed significantly worse than controls in emotion recognition and all ToM tasks (p < .02). These deficits were not correlated with demographic variables or neuropsychological test performance. These findings underscore the importance of assessing ToM and facial recognition in MS, as dysfunction in these areas may impact upon social interaction and, thus, impair quality of life for both patients with MS and their families. (JINS, 2011, 17, 1122–1131)
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Hoskinson, Kristen R., Erin D. Bigler, Tracy J. Abildskov, Maureen Dennis, H. Gerry Taylor, Kenneth Rubin, Cynthia A. Gerhardt, Kathryn Vannatta, Terry Stancin, and Keith Owen Yeates. "The mentalizing network and theory of mind mediate adjustment after childhood traumatic brain injury." Social Cognitive and Affective Neuroscience 14, no. 12 (December 2019): 1285–95. http://dx.doi.org/10.1093/scan/nsaa006.
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Abstract Childhood traumatic brain injury (TBI) affects over 600 000 children per year in the United States. Following TBI, children are vulnerable to deficits in psychosocial adjustment and neurocognition, including social cognition, which persist long-term. They are also susceptible to direct and secondary damage to related brain networks. In this study, we examine whether brain morphometry of the mentalizing network (MN) and theory of mind (ToM; one component of social cognition) mediates the effects of TBI on adjustment. Children with severe TBI (n = 15, Mage = 10.32), complicated mild/moderate TBI (n = 30, Mage = 10.81) and orthopedic injury (OI; n = 42, Mage = 10.65) completed measures of ToM and executive function and underwent MRI; parents rated children’s psychosocial adjustment. Children with severe TBI demonstrated reduced right-hemisphere MN volume, and poorer ToM, vs children with OI. Ordinary least-squares path analysis indicated that right-hemisphere MN volume and ToM mediated the association between severe TBI and adjustment. Parallel analyses substituting the central executive network and executive function were not significant, suggesting some model specificity. Children at greatest risk of poor adjustment after TBI could be identified based in part on neuroimaging of social brain networks and assessment of social cognition and thereby more effectively allocate limited intervention resources.
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Karafin, Matthew S., Daniel Tranel, and Ralph Adolphs. "Dominance Attributions Following Damage to the Ventromedial Prefrontal Cortex." Journal of Cognitive Neuroscience 16, no. 10 (December 2004): 1796–804. http://dx.doi.org/10.1162/0898929042947856.
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Damage to the human ventromedial prefrontal cortex (VM) can result in dramatic and maladaptive changes in social behavior despite preservation of most other cognitive abilities. One important aspect of social cognition is the ability to detect social dominance, a process of attributing from particular social signals another person's relative standing in the social world. To test the role of the VM in making attributions of social dominance, we designed two experiments: one requiring dominance judgments from static pictures of faces, the second requiring dominance judgments from film clips. We tested three demographically matched groups of subjects: subjects with focal lesions in the VM (n = 15), brain-damaged comparison subjects with lesions excluding the VM (n = 11), and a reference group of normal individuals with no history of neurological disease (n = 32). Contrary to our expectation, we found that subjects with VM lesions gave dominance judgments on both tasks that did not differ significantly from those given by the other groups. Despite their grossly normal performance, however, subjects with VM lesions showed more subtle impairments specifically when judging static faces: They were less discriminative in their dominance judgments, and did not appear to make normal use of gender and age of the faces in forming their judgments. The findings suggest that, in the laboratory tasks we used, damage to the VM does not necessarily impair judgments of social dominance, although it appears to result in alterations in strategy that might translate into behavioral impairments in real life.
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Butti, Niccolò, Rosario Montirosso, Lorenzo Giusti, Luigi Piccinini, Renato Borgatti, and Cosimo Urgesi. "Early Brain Damage Affects Body Schema and Person Perception Abilities in Children and Adolescents with Spastic Diplegia." Neural Plasticity 2019 (August 18, 2019): 1–17. http://dx.doi.org/10.1155/2019/1678984.
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Early brain damage leading to cerebral palsy is associated to core motor impairments and also affects cognitive and social abilities. In particular, previous studies have documented specific alterations of perceptual body processing and motor cognition that are associated to unilateral motor deficits in hemiplegic patients. However, little is known about spastic diplegia (SpD), which is characterized by motorial deficits involving both sides of the body and is often associated to visuospatial, attentional, and social perception impairments. Here, we compared the performance of a sample of 30 children and adolescents with SpD (aged 7-18 years) and of a group of age-matched controls with typical development (TD) at two different tasks tapping on body representations. In the first task, we tested visual and motor imagery abilities as assessed, respectively, by the object-based mental rotation of letters and by the first-person transformations for whole-body stimuli. In the second task, we administered an inversion effect/composite illusion task to evaluate the use of configural/holistic processing of others’ body. Additionally, we assessed social perception abilities in the SpD sample using the NEPSY-II battery. In line with previously reported visuospatial deficits, a general mental imagery impairment was found in SpD patients when they were engaged in both object-centered and first-person mental transformations. Nevertheless, a specific deficit in operating an own-body transformation emerged. As concerns body perception, while more basic configural processing (i.e., inversion effect) was spared, no evidence for holistic (i.e., composite illusion) body processing was found in the SpD group. NEPSY-II assessment revealed that SpD children were impaired in both the theory of mind and affect recognition subtests. Overall, these findings suggested that early brain lesions and biased embodied experience could affect higher-level motor cognition and perceptual body processing, thus pointing to a strict link between motor deficits, body schema alterations, and person processing difficulties.
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Shamay-Tsoory, S. G., R. Tomer, B. D. Berger, and J. Aharon-Peretz. "Characterization of Empathy Deficits following Prefrontal Brain Damage: The Role of the Right Ventromedial Prefrontal Cortex." Journal of Cognitive Neuroscience 15, no. 3 (April 1, 2003): 324–37. http://dx.doi.org/10.1162/089892903321593063.
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Impaired empathic response has been described in patients following brain injury, suggesting that empathy may be a fundamental aspect of the social behavior disturbed by brain damage. However, the neuroanatomical basis of impaired empathy has not been studied in detail. The empathic response of patients with localized lesions in the prefrontal cortex (n = 25) was compared to responses of patients with posterior (n = 17) and healthy control subjects (n = 19). To examine the cognitive processes that underlie the empathic ability, the relationships between empathy scores and the performance on tasks that assess processes of cognitive flexibility, affect recognition, and theory of mind (TOM) were also examined. Patients with prefrontal lesions, particularly when their damage included the ventromedial prefrontal cortex, were significantly impaired in empathy as compared to patients with posterior lesions and healthy controls. However, among patients with posterior lesions, those with damage to the right hemisphere were impaired, whereas those with left posterior lesions displayed empathy levels similar to healthy controls. Seven of nine patients with the most profound empathy deficit had a right ventromedial lesion. A differential pattern regarding the relationships between empathy and cognitive performance was also found: Whereas among patients with dorsolateral prefrontal damage empathy was related to cognitive flexibility but not to TOM and affect recognition, empathy scores in patients with ventromedial lesions were related to TOM but not to cognitive flexibility. Our findings suggest that prefrontal structures play an important part in a network mediating the empathic response and specifically that the right ventromedial cortex has a unique role in integrating cognition and affect to produce the empathic response.
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Corden, Ben, Hugo D. Critchley, David Skuse, and Raymond J. Dolan. "Fear Recognition Ability Predicts Differences in Social Cognitive and Neural Functioning in Men." Journal of Cognitive Neuroscience 18, no. 6 (June 2006): 889–97. http://dx.doi.org/10.1162/jocn.2006.18.6.889.
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By testing the facial fear-recognition ability of 341 men in the general population, we show that 8.8% have deficits akin to those seen with acquired amygdala damage. Using psychological tests and functional magnetic resonance imaging (fMRI) we tested the hypothesis that poor fear recognition would predict deficits in other domains of social cognition and, in response to socially relevant stimuli, abnormal activation in brain regions that putatively reflect engagement of the “social brain.” On tests of “theory of mind” ability, 25 “low fear scorers” (LFS) performed significantly worse than 25 age- and IQ-matched “normal (good) fear scorers” (NFS). In fMRI, we compared evoked activity during a gender judgement task to neutral faces portraying different head and eye gaze orientations in 12 NFS and 12 LFS subjects. Despite identical between-group accuracy in gender discrimination, LFS demonstrated significantly reduced activation in amygdala, fusiform gyrus, and anterior superior temporal cortices when viewing faces with direct versus averted gaze. In a functional connectivity analysis, NFS show enhanced connectivity between the amygdala and anterior temporal cortex in the context of direct gaze; this enhanced coupling is absent in LFS. We suggest that important individual differences in social cognitive skills are expressed within the healthy male population, which appear to have a basis in a compromised neural system that underpins social information processing.
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Place, Charlie. "Alcohol related brain damage – a case of neglect?" Advances in Dual Diagnosis 7, no. 3 (August 12, 2014): 129–36. http://dx.doi.org/10.1108/add-02-2014-0008.
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Purpose – The purpose of this paper is to argue that alcohol-related brain damage (ARBD) is a neglected problem. ARBD is a term that has begun to be used over the past decade to describe prolonged cognitive impairment caused by alcohol use, including Wernicke's encephalopathy and Korsakoff syndrome, alcohol dementia and alcohol-related brain injury. Design/methodology/approach – The paper provides an overview of ARBD describing the research around its prevalence and prognosis. There is a consensus in the literature that there is little research and a lack of awareness of this condition. The author uses case studies from his own experience working with people with ARBD to describe the difficulties in accessing appropriate assessment and care for this group, and suggests that they are often excluded in a way that is familiar from the experience of the person with “dual diagnosis”. Findings – Recommendations are made including raising awareness, improving screening for cognitive impairment and developing specialist services. Originality/value – ARBD appears to have been neglected in the “dual diagnosis” world and this paper attempts to address this, and so should be of interest to a wide range of professionals working with substance use, mental health, homelessness and social work.
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Koscik, Timothy R., and Daniel Tranel. "Abnormal Causal Attribution Leads to Advantageous Economic Decision-making: A Neuropsychological Approach." Journal of Cognitive Neuroscience 25, no. 8 (August 2013): 1372–82. http://dx.doi.org/10.1162/jocn_a_00398.
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People tend to assume that outcomes are caused by dispositional factors, for example, a person's constitution or personality, even when the actual cause is due to situational factors, for example, luck or coincidence. This is known as the “correspondence bias.” This tendency can lead normal, intelligent persons to make suboptimal decisions. Here, we used a neuropsychological approach to investigate the neural basis of the correspondence bias, by studying economic decision-making in patients with damage to the ventromedial pFC (vmPFC). Given the role of the vmPFC in social cognition, we predicted that vmPFC is necessary for the normal correspondence bias. In our experiment, consistent with expectations, healthy (n = 46) and brain-damaged (n = 30) comparison participants displayed the correspondence bias during economic decision-making and invested no differently when given dispositional or situational information. By contrast, vmPFC patients (n = 17) displayed a lack of correspondence bias and invested more when given dispositional than situational information. The results support the conclusion that vmPFC is critical for normal social inference and the correspondence bias. The findings help clarify the important (and sometimes disadvantageous) role of social inference in economic decision-making.
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Bault, Nadège, Giuseppe di Pellegrino, Martina Puppi, Gaëlle Opolczynski, Alessia Monti, Davide Braghittoni, Florence Thibaut, Aldo Rustichini, and Giorgio Coricelli. "Dissociation between Private and Social Counterfactual Value Signals Following Ventromedial Prefrontal Cortex Damage." Journal of Cognitive Neuroscience 31, no. 5 (May 2019): 639–56. http://dx.doi.org/10.1162/jocn_a_01372.
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Individuals learn by comparing the outcome of chosen and unchosen actions. A negative counterfactual value signal is generated when this comparison is unfavorable. This can happen in private as well as in social settings—where the foregone outcome results from the choice of another person. We hypothesized that, despite sharing similar features such as supporting learning, these two counterfactual signals might implicate distinct brain networks. We conducted a neuropsychological study on the role of private and social counterfactual value signals in risky decision-making. Patients with lesions in the ventromedial prefrontal cortex (vmPFC), lesion controls, and healthy controls repeatedly chose between lotteries. In private trials, participants could observe the outcomes of their choices and the outcomes of the unselected lotteries. In social trials, participants could also see the other player's choices and outcome. At the time of outcome, vmPFC patients were insensitive to private counterfactual value signals, whereas their responses to social comparison were similar to those of control participants. At the time of choice, intact vmPFC was necessary to integrate counterfactual signals in decisions, although amelioration was observed during the course of the task, possibly driven by social trials. We conclude that if the vmPFC is critical in processing private counterfactual signals and in integrating those signals in decision-making, then distinct brain areas might support the processing of social counterfactual signals.
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Koscik, Timothy R., and Daniel Tranel. "The Human Ventromedial Prefrontal Cortex Is Critical for Transitive Inference." Journal of Cognitive Neuroscience 24, no. 5 (May 2012): 1191–204. http://dx.doi.org/10.1162/jocn_a_00203.
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We hypothesized that the ventromedial pFC (vmPFC) is critical for making transitive inferences (e.g., the logical operation that if A > B and B > C, then A > C). To test this, participants with focal vmPFC damage, brain-damaged comparison participants, and neurologically normal participants completed a transitive inference task consisting an ordered set of arbitrary patterns. Participants first learned through trial-and-error the relationships of the patterns (e.g., Pattern A > Pattern B, Pattern B > Pattern C). After initial learning, participants were presented with novel pairings, some of which required transitive inference (e.g., Pattern A > Pattern C from the relationship above). We observed that vmPFC damage led to a specific deficit in transitive inference, suggesting that an intact vmPFC is necessary for making normal transitive inferences. Given the usefulness of transitivity in inferring social relationships, this deficit may be one of the basic features of social conduct problems associated with vmPFC damage.
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Kalantarova, M. V., L. B. Zavaliy, E. V. Borisonik, M. I. Subotich, A. V. Grechko, I. G. Shchelkunova, and S. S. Petrikov. "Digital Technologies in Rehabilitation of Patients with Focal Brain Injury." Консультативная психология и психотерапия 28, no. 3 (2020): 122–41. http://dx.doi.org/10.17759/cpp.2020280308.
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Focal damage of the brain leads to cognitive impairments, which sufficiently limit the person’s functional capabilities, which, in turn, can lead to secondary disorders of the emotional and personal sphere and social maladjustment. The need to include cognitive rehabilitation in the system of complex treatment methods for patients with focal brain lesions is generally recognized. The article describes methods of neurorehabilitation based on high technologies and indicates their place in the general rehabilitation process. Data yielded by domestic and foreign studies on the effectiveness of digital technologies in the cognitive rehabilitation of patients with focal brain lesions is presented.
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Tomaszewski, Dariusz. "Biomarkers of Brain Damage and Postoperative Cognitive Disorders in Orthopedic Patients: An Update." BioMed Research International 2015 (2015): 1–16. http://dx.doi.org/10.1155/2015/402959.
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The incidence of postoperative cognitive dysfunction (POCD) in orthopedic patients varies from 16% to 45%, although it can be as high as 72%. As a consequence, the hospitalization time of patients who developed POCD was longer, the outcome and quality of life were worsened, and prolonged medical and social assistance were necessary. In this review the short description of such biomarkers of brain damage as the S100B protein, NSE, GFAP, Tau protein, metalloproteinases, ubiquitin C terminal hydrolase, microtubule-associated protein, myelin basic protein,α-II spectrin breakdown products, and microRNA was made. The role of thromboembolic material in the development of cognitive decline was also discussed. Special attention was paid to optimization of surgical and anesthetic procedures in the prevention of postoperative cognitive decline.
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Meenan, Suzanne, and Roger Lindsay. "Planning and the neurotechnology of social behaviour." International Journal of Cognition and Technology 1, no. 2 (December 31, 2002): 233–74. http://dx.doi.org/10.1075/ijct.1.2.03mee.
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The human brain has a remarkable ability to generate plans for sequences of actions that allow human agents to co-operate with and to manipulate the behaviour of others. It is widely claimed that the operations underlying plan developments, behaviour sequencing and inhibition of inappropriate responses to the environment are carried out in the prefrontal cortex. This implies that the prefrontal cortex is a natural system with the capacity to utilise cognitive technology. The present paper argues that social competence is a manifestation of action planning in which other agents feature as plan elements. Accordingly, plans that involve other agents are expected to be more complex than plans which do not. In the light of evidence that negative information makes particularly heavy processing demands, social judgements involving prohibition or unacceptability are expected to create most difficulty for the human action planning system. These assumptions were tested by measuring the ability of patients with prefrontal injuries to detect anomalous action sequences, using a specially constructed Action Acceptability Test. It was hypothesised that if the frontal lobes play a major role in action planning, patients with frontal lobe injuries should show impaired ability to detect faulty action plans, particularly when such plans relate to complex social action sequences, and action sequences involving unacceptable behaviours. The hypotheses were generally supported as frontal-injury patients proved to be worse at detecting both complex social sequences and deviant action sequences than participants with non-frontal injuries and normal control participants. The results of the study are consistent with the view that human social competence results from the cognitive processes associated with action planning and the data also supports the claim that action planning processes are specifically disrupted by damage to the prefrontal cortex. The findings provide some confirmation for the Cognitive Technology perspective, in that action planning does seem to be physically associated with a specific brain area, and including social agents and deviations from acceptability in action plans do seem to be manipulations that operate to make action plans more difficult to process, hence causing more errors in individuals with damage to the prefrontal cortex. The results also provide some encouragement for the belief that new cognitive tools can be constructed that link brain processes to other levels of description, such as social behaviour. The Action Acceptability Test, a prognostic tool developed to predict the social competence of frontal-injury patients, is offered as one such example.
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Moll, Jorge, Ricardo de Oliveira-Souza, Rodrigo Basilio, Ivanei Edson Bramati, Barry Gordon, Geraldine Rodríguez-Nieto, Roland Zahn, Frank Krueger, and Jordan Grafman. "Altruistic decisions following penetrating traumatic brain injury." Brain 141, no. 5 (March 24, 2018): 1558–69. http://dx.doi.org/10.1093/brain/awy064.
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Abstract The cerebral correlates of altruistic decisions have increasingly attracted the interest of neuroscientists. To date, investigations on the neural underpinnings of altruistic decisions have primarily been conducted in healthy adults undergoing functional neuroimaging as they engaged in decisions to punish third parties. The chief purpose of the present study was to investigate altruistic decisions following focal brain damage with a novel altruistic decision task. In contrast to studies that have focused either on altruistic punishment or donation, the Altruistic Decision Task allows players to anonymously punish or donate to 30 charitable organizations involved with salient societal issues such as abortion, nuclear energy and civil rights. Ninety-four Vietnam War veterans with variable patterns of penetrating traumatic brain injury and 28 healthy veterans who also served in combat participated in the study as normal controls. Participants were asked to invest $1 to punish or reward real societal organizations, or keep the money for themselves. Associations between lesion distribution and performance on the task were analysed with multivariate support vector regression, which enables the assessment of the joint contribution of multiple regions in the determination of a given behaviour of interest. Our main findings were: (i) bilateral dorsomedial prefrontal lesions increased altruistic punishment, whereas lesions of the right perisylvian region and left temporo-insular cortex decreased punishment; (ii) altruistic donations were increased by bilateral lesions of the dorsomedial parietal cortex, whereas lesions of the right posterior superior temporal sulcus and middle temporal gyri decreased donations; (iii) altruistic punishment and donation were only weakly correlated, emphasizing their dissociable neuroanatomical associations; and (iv) altruistic decisions were not related to post-traumatic personality changes. These findings indicate that altruistic punishment and donation are determined by largely non-overlapping cerebral regions, which have previously been implicated in social cognition and moral experience such as evaluations of intentionality and intuitions of justice and morality. 10.1093/brain/awy064_video1 awy064media1 5758316955001
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Heberlein, Andrea S., Ralph Adolphs, James W. Pennebaker, and Daniel Tranel. "Effects of Damage to Right-Hemisphere Brain Structures on Spontaneous Emotional and Social Judgments." Political Psychology 24, no. 4 (December 2003): 705–26. http://dx.doi.org/10.1046/j.1467-9221.2003.00348.x.
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Vilks, Andrejs, and Aldona Kipāne. "Criminology as Trends in the Development of Science." SOCRATES. Rīgas Stradiņa universitātes Juridiskās fakultātes elektroniskais juridisko zinātnisko rakstu žurnāls / SOCRATES. Rīga Stradiņš University Faculty of Law Electronic Scientific Journal of Law 1, no. 19 (2021): 39–48. http://dx.doi.org/10.25143/socr.19.2020.1.039-048.
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Criminology has a special place and is of special significance in law science. It does not always examine substantive or procedural rules and case law. The authors of the article emphasise criminology as a science of social law, the dominant object of cognition of which is socially significant phenomena (crime, drugs, corruption, prostitution, etc.), as well as the processes related to their combating and prevention. Crime is the product of various contradictions that evolve in society, a negatively directed function of society that reflects its resulting state of moral and social “health”. Dynamic social, economic, political, legal, administrative, organisational and other factors determine the constant cognition of socially undesirable and negative phenomena, improvement of research tools and approaches. Crime is transforming alongside social changes, in some cases even accelerating them. Despite the unjustified discounting of the significance of criminology as an independent science, it continues to develop. In the social science system criminology functions as a mission, creating an uncompromising attitude towards crime. Under the current circumstances and in line with the intense invasion of modern technologies crime is taking on new forms and shapes. It successfully moves to the virtual environment, increasing its latency level and significantly complicating the magnitude and negative effects of damage detection. A new modified field of cognition of crime and its related elements a arising – digital criminology. It could play an important role in the qualitative analysis and forecasting of crime, in identifying the determinants of crime, and in determining their impact on crime. Digital methods of examination of persons, including the use of positron emission tomography (PET) of brain scanning, would make it possible to identify persons with pronounced criminal inclinations. Digital technologies could be used in correctional institutions and establishments to help those who have served prison sentences related to deprivation of liberty, in their rehabilitation, as well as in the implementation of virtual deprivation of liberty and replacing of expensive and inefficient prisons with digital detention facilities.
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Svyrydova, N. K., and N. P. Pavliuk. "Strategy for the treatment of cognitive disorders in patients with chronic brain ischemia and initial manifestations of insufficient blood supply to the brain." East European Journal of Neurology, no. 5(5) (December 20, 2015): 27–32. http://dx.doi.org/10.33444/2411-5797.2015.5(5).2-7.
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Cerebrovascular accidents are the most important med- ical and social problem due to their high frequency in the structure of morbidity and mortality, as well as significant indicators of disability in the population. The severity of cognitive deficits in patients with cerebrovascular disease are more correlated not with territorial infarcts caused by the defeat of the major cerebral arteries, and on microvascular pathology (a minor heart attack, multiple lacunar infarcts, microbleeds), as well as cerebral atrophy, which may be due to vascular brain damage and specific neurodegenerative process. Since effective therapeutic drugs treat persistent cognitive impairment in the present does not exist, an alternative could be a strategy of weakening of cognitive impairment and their progression. The article describes the characteristics, the description of the results of worldwide research application components that are complex and herbal preparations Memokor Neokardil.
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Oprandi, Maria Chiara, Viola Oldrati, Morena delle Fave, Daniele Panzeri, Lorenza Gandola, Maura Massimino, Alessandra Bardoni, and Geraldina Poggi. "Processing Speed and Time since Diagnosis Predict Adaptive Functioning Measured with WeeFIM in Pediatric Brain Tumor Survivors." Cancers 13, no. 19 (September 24, 2021): 4776. http://dx.doi.org/10.3390/cancers13194776.
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(1) Background: Brain tumor (BT) survivors show difficulties in the acquisition of developmental milestones, related to academic achievement, vocational employment, social relationships, and autonomy. The skills underlying adaptive functioning (AF) are usually damaged in BT survivors due to the presence of the brain tumor, treatment-related factors, and other neurological sequelae. In this study, we aimed to explore the contribution of different cognitive factors in children with BT to AF, considering diagnosis-related variables. (2) Methods: Standardized cognitive assessment was undertaken and clinical information was collected from a retrospective cohort of 78 children with a BT, aged between 6 and 18 year old at the time of the assessment. Regression models were computed to investigate the influence of the selected variables on daily functional skills as measured by the Functional Independence Measure for Children (WeeFIM). (3) Results: The analyses showed that the main explanatory variables are processing speed and time since diagnosis. Other clinical variables, such as age at diagnosis and hydrocephalus, differentially influence functional skills according to distinct domains (i.e., self-care, mobility, and cognition). (4) Conclusions: The main explanatory variables of AF that emerged in our models point to a potential target of improving AF management in pediatric BT survivors.
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Vilkki, J., P. Holst, J. öhman, A. Servo, and O. Heiskanen. "Social Outcome Related to Cognitive Performance and Computed Tomographic Findings after Surgery for a Ruptured Intracranial Aneurysm." Neurosurgery 26, no. 4 (April 1, 1990): 579–85. http://dx.doi.org/10.1227/00006123-199004000-00004.
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Abstract A series of 83 patients was examined with a battery of cognitive tests, a clinical interview, and computed tomography 1 year after surgery for a ruptured intracranial aneurysm. Disability on the Glasgow Outcome Scale (33%), failure to return to work (25%), impaired social relations (25%), and subjective or clinical mental impairment (56%) were found to be related to each other and to poor performance on cognitive tests, especially to verbal impairments in patients with left lateral infarctions and to memory deficits and cognitive inflexibility in patients with frontal medial infarctions. Furthermore, cognitive deficits and poor outcome were associated with diffuse brain damage. Depression and anxiety were unrelated to test performances, but were frequently reported by patients with right lateral infarctions.
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Lazeron, R. HC, J. B. Boringa, M. Schouten, B. MJ Uitdehaag, E. Bergers, J. Lindeboom, M. J. Eikelenboom, P. H. Scheltens, F. Barkhof, and C. H. Polman. "Brain atrophy and lesion load as explaining parameters for cognitive impairment in multiple sclerosis." Multiple Sclerosis Journal 11, no. 5 (October 2005): 524–31. http://dx.doi.org/10.1191/1352458505ms1201oa.
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Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system, with lesions widespread through the brain and spinal cord. An important manifestation is cognitive impairment, which, though difficult to measure, may have a major social impact. To better understand the relationship between structural tissue damage and cognitive impairment, we examined the extent and spatial distribution of brain lesions, as measured by magnetic resonance imaging (MRI), in relation to abnormal cognitive performance as measured by the Brief Repeatable Battery (BRB) in 82 MS patients. Possible confounders, like fatigue, pain and depression were also assessed. Brain MR image analysis included hyperintense T2 and hypointense T1 lesion load in the whole brain and the four lobes separately, as well as whole brain volume measurements. Cognitive impairment (defined as more than two abnormal tests) was found in 67% of the patients. Moderately strong correlations were found between the subtests of the BRB and the lesion loads in the brain regions hypothesized to be associated with that cognitive test, although these correlations were in general not much stronger than those between the subtests and the overall lesion load (due to strong interrelationships). The Spatial Recall Test correlated best with parietal lesion load; the Symbol Digit Modalities Test, the Paced Auditory Serial Addition Task (PASAT) and the Word List Generation best with frontal, parietal and temporal lesion load; while the Verbal List Generation Test Index correlated only with atrophy. Atrophy and lesion load were the main factors determining the test scores, explaining 10-25% of the variance in the test results, and were more important than fatigue, pain and depression; only depression had a minor, but significant, additional effect on the PASAT. In conclusion, cognitive impairment in MS is moderately dependent on amount (and distribution) of structural brain damage, especially in the more physically impaired patients group.
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Wahab, M. M. Abdel, H. Hussien, and K. M. Maher. "Delayed cognitive, behavioral, and radiological changes related to canial irradiation for pediatric brain tumors." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 20023. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.20023.
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20023 Purpose: To evaluate the delayed adverse changes in neuro-cognitive functions as well as white matter damage in radiated survivors of pediatric brain tumors. Methods: Forty two children (22 males) with primary brain tumors who were only treated with cranial radiation, were recruited. 28 patients were treated for low risk medulloblastoma, 10 patients for low grade astrocytoma, 3 patients for low grade ependymoma, and 1 patient for craniopharyngioma. Their ages ranged from 3 to 18 years (mean 10.3±3.98 years).They were subjected, initially just before radiotherapy and at follow-up 1–2 year after completion of cranial radiation, to serial clinical and neuropsychological assessments including Wechseler Intelligence Scale for Children, Vineland social maturity test, Benton Visual Memory Test, and Revised Behavior Problem Checklist. Magnetic resonance scans were also performed to detect the presence of white matter damage before radiotherapy and at follow up. Results: Initially, after surgery and before radiation, intelligence test scores were below normal scores for age and this was of high statistical significance (Total IQ: t= -3.02, P= 0.006). Visual memory test showed evidence of organicity in all cases. Social maturity showed a statistically significant decline as well (t= -2.11, P= 0.04). Follow-up after radiotherapy showed further decline with high statistical significance (Total IQ t= 3.228, P=0.003; visual memory t= 4.08, P= 0.001); An attentional problem has emerged (t= -6.12, P= 0.00). Both radiation dose and volume of radiation showed negative and statistically significant correlation with IQ. Age at diagnosis correlated positively and significantly with IQ ( r= 0.601, P=0.001). Multiple linear regression showed impaired neurocognitive function which was correlated with the degree of white matter damage. (standardized B= -0.577, P= 0.001) and young age at diagnosis (standardized B= -0.427, P= 0.014). Conclusions: Cranial radiation in pediatric brain tumors is associated with a decline in multiple neurocognitive functions including total IQ, visual memory, and attention; which are related to the toxic effect of cranial radiation on white matter of the brain especially in young age of childhood with high dose and whole cranial radiation. No significant financial relationships to disclose.
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Lobzin, V. Yu, K. A. Kolmakova, A. Yu Emelin, and S. N. Yanishevskiy. "Arterial hypertension and Alzheimer’s disease. Prologue to neurodegeneration." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 25, no. 2 (July 29, 2019): 122–33. http://dx.doi.org/10.18705/1607-419x-2019-25-2-122-133.
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Cognitive impairment is a global medical and social problem. Alzheimer’s disease (AD) is the most common disease leading to the development of cognitive impairment and dementia. Arterial hypertension (HTN) is considered to be the strongest risk factor for the development of both vascular dementia and AD. Recent studies have demonstrated the importance of the glymphatic system in removing β-amyloid from the brain through the perivascular Virchow–Robin spaces. The interest is that the adequate functioning of the glymphatic system mainly depends on the level of blood pressure during the day and the quality of sleep. In this article, we will consider the main mechanisms of the HTN influence on the glymphatic system, brain substance-related damage and the development of cognitive impairment.
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Michel, Caroline, Laurence Dricot, Renaud Lhommel, Cécile Grandin, Adrian Ivanoiu, Agnesa Pillon, and Dana Samson. "Extensive Left Temporal Pole Damage Does Not Impact on Theory of Mind Abilities." Journal of Cognitive Neuroscience 25, no. 12 (December 2013): 2025–46. http://dx.doi.org/10.1162/jocn_a_00488.
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The temporal poles (TPs) are among the brain regions that are often considered as the brain network sustaining our ability to understand other people's mental states or “Theory of Mind” (ToM). However, so far the functional role of the left and right TPs in ToM is still debated, and it is even not clear yet whether these regions are necessary for ToM. In this study, we tested whether the left TP is necessary for ToM by assessing the mentalizing abilities of a patient (C.M.) diagnosed with semantic dementia. Converging evidence from detailed MRI and 18F-fluoro-2-deoxy-d-glucose PET examinations showed a massive atrophy of the left TP with the right TP being relatively unaffected. Furthermore, C.M.'s atrophy encompassed most regions of the left TP usually activated in neuroimaging studies investigating ToM. Given C.M.'s language impairments, we used a battery of entirely nonverbal ToM tasks. Across five tasks encompassing 100 trials, which probed the patient's ability to attribute various mental states (intentions, knowledge, and beliefs), C.M. showed a totally spared performance. This finding suggests that, despite its consistently observed activation in neuroimaging studies involving ToM tasks, the left TP is not necessary for ToM reasoning, at least in nonverbal conditions and as long as its right counterpart is preserved. Implications for understanding the social abilities of patients with semantic dementia are discussed.
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Pavlova, Marina, Alexander N. Sokolov, Niels Birbaumer, and Ingeborg Krägeloh-Mann. "Perception and Understanding of Others' Actions and Brain Connectivity." Journal of Cognitive Neuroscience 20, no. 3 (March 2008): 494–504. http://dx.doi.org/10.1162/jocn.2008.20034.
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Perception and understanding of dispositions and intentions of others through their actions are of immense importance for adaptive daily-life behavior and social communication. Here we ask whether, and, if so, how this ability is impaired in adolescents who were born premature and suffer early periventricular damage, periventricular leukomalacia (PVL) that affects brain connectivity. The visual event arrangement (EA) task was administered to PVL patients and two control groups, premature-born and term-born adolescents without brain abnormalities on a magnetic resonance imaging scan. Performance on the EA task was significantly lower in PVL patients as compared with controls. No difference was found between premature-born participants without lesions and term-born controls. Performance on the EA task was inversely related to the volumetric extent of lesions in the parieto-occipital regions of both hemispheres and, in particular, to the right temporal periventricular lesions. Whereas our earlier work reveals that compromised visual processing of biological motion, impairments in visual navigation, and other visual-perceptual disabilities in PVL patients are associated with parieto-occipital lesions, difficulties in the visual EA task solely are specifically linked to the right temporal periventricular lesions. For the first time, we show that the severity of the right temporal PVL can serve as a predictor of the ability for perception and understanding of others' actions. We assume that impairments in this ability in PVL patients are caused by disrupted brain connectivity to the right temporal cortex, a key node of the social brain.
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Gindri, Gigiane, Karina Carlesso Pagliarin, Fabíola Schwengber Casarin, Perrine Ferré, Yves Joanette, and Rochele Paz Fonseca. "Rehabilitation of discourse impairments after acquired brain injury." Dementia & Neuropsychologia 8, no. 1 (March 2014): 58–65. http://dx.doi.org/10.1590/s1980-57642014dn81000009.
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ABSTRACT Language impairments in patients with acquired brain injury can have a negative impact on social life as well as on other cognitive domains. Discourse impairments are among the most commonly reported communication deficits among patients with acquired brain damage. Despite advances in the development of diagnostic tools for detecting such impairments, few studies have investigated interventions to rehabilitate patients presenting with these conditions. Objective: The aim of this study was to present a systematic review of the methods used in the rehabilitation of discourse following acquired brain injury. Methods: The PubMed database was searched for articles using the following keywords: "rehabilitation", "neurological injury", "communication" and "discursive abilities". Results: A total of 162 abstracts were found, but only seven of these met criteria for inclusion in the review. Four studies involved samples of individuals with aphasia whereas three studies recruited samples of individuals with traumatic brain injury. Conclusion: All but one article found that patient performance improved following participation in a discourse rehabilitation program.
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Kemeny, Margaret E. "The Psychobiology of Stress." Current Directions in Psychological Science 12, no. 4 (August 2003): 124–29. http://dx.doi.org/10.1111/1467-8721.01246.
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Stressful life experience can have significant effects on a variety of physiological systems, including the autonomic nervous system, the hypothalamic-pituitary-adrenal axis, and the immune system. These relationships can be bidirectional; for example, immune cell products can act on the brain, altering mood and cognition, potentially contributing to depression. Although acute physiological alterations may be adaptive in the short term, chronic or repeated provocation can result in damage to health. The central dogma in the field of stress research assumes a stereotyped physiological response to all stressors (the generality model). However, increasing evidence suggests that specific stressful conditions and the specific way an organism appraises these conditions can elicit qualitatively distinct emotional and physiological responses (the integrated specificity model). For example, appraisals of threat (vs. challenge), uncontrollability, and negative social evaluation have been shown to provoke specific psychobiological responses. Emotional responses appear to have specific neural substrates, which can result in differentiated alterations in peripheral physiological systems, so that it is incorrect to presume a uniform stress response.
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Ellingsen, Kjersti L., and Randi W. Aas. "Work Participation After Acquired Brain Injury: Experiences of Inhibiting and Facilitating Factors." International Journal of Disability Management 4, no. 1 (April 1, 2009): 1–11. http://dx.doi.org/10.1375/jdmr.4.1.1.
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AbstractAim: The aim of this study was to provide new insight into the factors that affect work participation by those with cognitive deficits following an acquired brain injury. Method: The study had a qualitative exploratory design, with three focus-group interviews used to collect data. The first group comprised workers with experience of cognitive deficits after a traumatic brain injury (TBI), anoxic brain damage and stroke, the second group professionals from specialist levels of social security service and the third professionals from specialised health care services. Transcribed interviews were analysed using a conventional approach to content analysis. Major findings: A broad range of factors affected work participation. Personal factors, the psychosocial adaptation process, injury-related consequences as well as factors in the working environment were found to inhibit work participation. Acceptance of a different level of functioning and a new role in working life was an important but time-consuming process. Significant working-environment barriers were workplace demands, the attitudes of employers and colleagues, complicated information, excessive bureaucracy, too little practice before going back to work and physical barriers. Optimism and being determined were found to be particularly important facilitating personal factors. Important resources provided by the working environment were social support, time-related flexibility, relevant tasks and accommodations.
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Aida, Tamami. "Effect of VR for education to promote the social participation of people with cognitive disorders caused by acquired brain injuries." Impact 2021, no. 6 (July 15, 2021): 54–56. http://dx.doi.org/10.21820/23987073.2021.6.54.
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Brain injuries will often result in some form of permanent damage and lead to disorders such as cognitive and behavioural problems. Although treatments are available, it is likely that the patient and their family will have to learn to live with the disorder and the patient may face challenges related to workplaces and care networks. Ultimately, this can result in the patient retreating from society, which can be damaging to mental health. Professor Tamami Aida, Mejiro University, Japan, is a Director at the Japanese non-profit organisation Minna no centre Omusubi which seeks to make better, more inclusive lives for people with long-term brain injuries. Aida is currently working on a project to help different people involved in the care and treatment of those with acquired brain injuries (ABI). A key focus is educating stakeholders on the process of vocational rehabilitation (VR), which is the end goal of a long process from initial brain injury representing a return to work. She has created informative materials to enlighten stakeholders on the needs of ABI patients and the process of VR, including a video that explains VR and highlights the necessary input of those involved in the care of ABI patients. Ultimately, Aida wants to ensure that people with ABI have a suitable framework to rebuild their lives.
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Cutuli, D., D. Ladrón de Guevara-Miranda, E. Castilla-Ortega, L. J. Santín, and P. Sampedro-Piquero. "Highlighting the Role of Cognitive and Brain Reserve in the Substance use Disorder Field." Current Neuropharmacology 17, no. 11 (October 2, 2019): 1056–70. http://dx.doi.org/10.2174/1570159x17666190617100707.
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Background:Cognitive reserve (CR) refers to the ability of an individual to cope with brain pathology remaining free of cognitive symptoms. This protective factor has been related to compensatory and more efficient brain mechanisms involved in resisting brain damage. For its part, Brain reserve (BR) refers to individual differences in the structural properties of the brain which could also make us more resilient to suffer from neurodegenerative and mental diseases.Objective:This review summarizes how this construct, mainly mediated by educational level, occupational attainment, physical and mental activity, as well as successful social relationships, has gained scientific attention in the last years with regard to diseases, such as neurodegenerative diseases, stroke or traumatic brain injury. Nevertheless, although CR has been studied in a large number of disorders, few researches have addressed the role of this concept in drug addiction.Methods:We provide a selective overview of recent literature about the role of CR and BR in preventing substance use onset. Likewise, we will also discuss how variables involved in CR (healthy leisure, social support or job-related activities, among others) could be trained and included as complementary activities of substance use disorder treatments.Results:Evidence about this topic suggests a preventive role of CR and BR on drug use onset and when drug addiction is established, these factors led to less severe addiction-related problems, as well as better treatment outcomes.Conclusion:CR and BR are variables not taken yet into account in drug addiction. However, they could give us a valuable information about people at risk, as well as patient’s prognosis.
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Gil-Pagés, Macarena, Rocío Sánchez-Carrión, Jose M. Tormos, Antonia Enseñat-Cantallops, and Alberto García-Molina. "A Positive Relationship between Cognitive Reserve and Cognitive Function after Stroke: Dynamic Proxies Correlate Better than Static Proxies." Journal of the International Neuropsychological Society 25, no. 09 (July 18, 2019): 910–21. http://dx.doi.org/10.1017/s1355617719000638.
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AbstractObjectives: How brain damage after stroke is related to specific clinical manifestation and recovery is incompletely understood. We studied cognitive reserve (CR) in stroke patients by two types of measurements: (i) objectively verifiable static proxies (i.e., education, occupational attainment), and (ii) subjective, dynamic proxies based on patient testimony in response to a questionnaire. We hypothesized that one or both of these types of CR measurements might correlate positively with patient cognitive performance during the post-acute and chronic phases of recovery. Method: Thirty-four stroke patients underwent neuropsychological assessment at 2, 6 and 24 months after stroke onset. In chronic stage at 24+ months, self-rating assessments of cognitive performance in daily life and social integration were obtained. CR before and after stroke was estimated using static proxies and dynamic proxies were obtained using the Cognitive Reserve Scale (CRS-Pre-stroke, CRS-Post-stroke). Results: CRS-Pre-stroke and CRS-Post-stroke showed significant mean differences. Dynamic proxies showed positive correlation with self-assessment of attention, metacognition, and functional ability in chronic stage. In contrast, significant correlations between static proxies and cognitive recovery were not found. Conclusions: Dynamic proxies of CR were positively correlated with patients’ perception of their functional abilities in daily life. To best guide cognitive prognosis and treatment, we propose that dynamic proxies of CR should be included in neuropsychological assessments of patients with brain damage.
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Immordino-Yang, Mary Helen, and Antonio Damasio. "We Feel, Therefore We Learn: The Relevance of Affective and Social Neuroscience to Education." LEARNing Landscapes 5, no. 1 (May 1, 2011): 115–31. http://dx.doi.org/10.36510/learnland.v5i1.535.
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Recent advances in neuroscience are highlighting connections between emotion, social functioning, and decision making that have the potential to revolutionize our understanding of the role of affect in education. In particular, the neurobiological evidence suggests that the aspects of cognition that we recruit most heavily in schools, namely learning, attention, memory, decision making, and social functioning, are both profoundly affected by and subsumed within the processes of emotion; we call these aspects emotional thought. Moreover, the evidence from brain-damaged patients suggests the hypothesis that emotion-related processes are required for skills and knowledge to be transferred from the structured school environment to real-world decision making because they provide an emotional rudder to guide judgment and action. Taken together, the evidence we present sketches an account of the neurobiological underpinnings of morality, creativity, and culture, all topics of critical importance to education. Our hope is that a better understanding of the neurobiological relationships between these constructs will provide a new basis for innovation in the design of learning environments.
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Iancheva, Dessislava, Anastasiya Trenova, Stefka Mantarova, and Kiril Terziyski. "Structural and Functional MRI Techniques in Multiple Sclerosis Related Cognitive Dysfunction." Folia Medica 60, no. 4 (December 1, 2018): 505–11. http://dx.doi.org/10.2478/folmed-2018-0031.
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Abstract Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system that is prevalent in young adults and therefore with significant social impact. Cognitive impairment occurs in 40% to 70% of patients with MS and has a weak correlation with disease duration. Neuropsycho-logical assessment is a standard method in the detection of cognitive dysfunction. However, in order to understand the etiology and evolution of cognitive dysfunction, several elaborate magnetic resonance techniques have been developed. Their aim is to measure structural changes in the CNS that are considered main substrates in cognitive function such as whole brain and gray matter atrophy, cortical lesions and changes in subcortical gray matter. Evidence shows that the clinical manifestations of multiple sclerosis are complex interactions between tissue damage, tissue repair and cortical reorganization. In order to study this heterogeneity, structural magnetic resonance analysis of brain morphology and functional magnetic resonance imaging are essential. This review summarizes current techniques in structural MRI and the value of functional MRI in understanding the link between cognitive deficit and cortical activation and reorganization.
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Pąchalska, Maria. "Lurian Approach and Neuropsychology of Creativity." Lurian Journal 1, no. 1 (July 16, 2020): 77–108. http://dx.doi.org/10.15826/lurian.2020.1.1.7.
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Background. Alexander Romanovich Luria (1902–1977) is a widely recognized authority, attributed with the birth and development of neuropsychology. Reading the list of Luria’s publications makes us aware of the wide range of his interests: from the brain location of mental functions, through methods of rehabilitation and education, cognitive processing, issues of language, intellectual development or the impact of culture on human development, to intercultural research, and consequently to the neuropsychology of creativity. The purpose of this article is to show the link between Luria’s approach and the neuropsychology of creativity, and to demonstrate that a process thinking, taking into account brain/mind state, offers a new way of conceptualizing different approaches to creativity, which can be a step toward their unification, bringing into relation the continuum of passage in nature to a transition from repetition to innovation to genius. Objective. The aim of the present paper is to present the brain mechanisms of creativity. It discusses the neuropsychology of creativity as a subdiscipline developing on the borderline of: (1) medical neuroscience — using clinical and experimental neuroanatomical, neurophysiological, neurobiological, neurosurgical, neurological, neuropsychiatric and (2) social neuroscience — using social psychology and neuropsychology, social linguistics and neurocultural studies to help disabled people. Special focus is placed on the functioning of artists with various forms of brain damage. The relationships between brain damage and the quality of creation are also discussed. In addition, a review of opinions of various authors from around the world on the relationship of the healthy and the damaged brain with creativity is presented in the paper. Case study. Described also are ways to avoid pitfalls in the interpretation of works of art taking into account Luria’s syndrom analysis. While studying the neurological and neuropsychiatric basis of the creativity of people with various brain injuries, one should take into account the possibility of the co-occurrence of syndromes as well as the overlapping of symptoms. The paper presents a case history of the illness of an artist that illustrates the importance of performing a syndrome analysis based on the Lurian approach. It also indicates the significance of supporting any neuropsychological assessment with the use of neuromarkers to avoid arriving at a false diagnosis. In the case of the patient described neurophysiological studies (neuroimaging studies of the brain, quantitative electroencephalography (qEEG), event-related potentials (ERPs) and standardized Low Resolution Electromagnetic Tomography (sLORETA) have proved to be very useful in the confirmation of his neuropsychological and neuropsychiatric diagnosis. Conclusions. The paper has presented data confirming the importance of Luria’s approach in the development of the neuropsychology of creativity. It was also an attempt to explain why we create, and what goes on in our bodies and minds when we begin to explore creative possibilities. Art in all of its manifestations (visual art, music, literature, dance, theater, and more) is an important feature of human societies in both norm and pathology, and therefore deserves further study.
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Guilmette, Thomas J., Frank R. Sparadeo, William Whelihan, and Gregg Buongiorno. "Validity of Neuropsychological Test Results in Disability Evaluations." Perceptual and Motor Skills 78, no. 3_suppl (June 1994): 1179–86. http://dx.doi.org/10.2466/pms.1994.78.3c.1179.
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A group of 50 disability claimants referred by the Social Security Administration for neuropsychological screening were administered a 36-item, forced-choice, digit-recognition method of detecting malingering to assess effort and motivation to perform well. This abbreviated form of the 1989 Hiscock and Hiscock Forced-choice Procedure has been shown to be quite easy even for individuals with severe organic brain dysfunction. A perfect performance of 36 correct on this digit-recognition task is obtained by most individuals with moderate to severe brain damage. A performance of less than 90% correct is due more likely to poor effort or even malingering rather than brain damage. In this sample, 18% ( n = 9) obtained scores of less than 90% correct, i.e., <33, which calls into question the reliability and validity of test data obtained. An additional 20% ( n = 10) obtained intermediate scores of 33 to 35 correct. These intermediate scores are more difficult to interpret although at least some proportion of those scores reflects poor motivation. The results over-all indicate that nearly one-fifth of potential disability claimants produced invalid and uninterpretable neuropsychological test protocols and an additional one-fifth obtained protocols that should be well scrutinized for evidence of poor effort as well. Neuropsychologists conducting disability evaluations are urged to use measures designed specifically to assess effort and motivation.
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Staniloiu, A., and H. J. Markowitsch. "FC29-04 - Gene-brain -environment interactions in violent behavior." European Psychiatry 26, S2 (March 2011): 1980. http://dx.doi.org/10.1016/s0924-9338(11)73683-5.
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IntroductionThe prediction, prevention and treatment of violence pose several challenges that are partly due to incompletely described neurobiological underpinnings of human violent behavior.ObjectivesThis work's objectives are establishing greater recognition of the neurochemical substrates of violent behavior and importance of the gene-environment interplay in the development of violence, distinguishing the components of the functional neural networks involved in violent behavior and facilitating the interpretation of relations between brain damage and alterations in social behavior from a perspective that takes into account variables such as developmental phase, brain-environment interactions and neuroplasticity.AimsWe provide an overview of the neurobiological underpinnings of violence and the roles and advantages of using static and functional brain imaging in studying violent behavior.MethodsA comprehensive review of the scientific literature on the neurobiology of violence was performed. A theoretical framework for the possible role of epigenetic factors in mediating the predisposition for violence is advanced.ResultsResearch data from various fields (such as genetics, cognitive and affective neurosciences, static and functional neuroimaging) suggest that the predisposition for violent behavior is influenced by both genetic and environmental factors. Epigenetic mechanisms underlying lasting environmentally-induced modifications in gene expression have recently been implicated in the pathogeny of various psychiatric and non-psychiatric diseases and social behavior disturbances.ConclusionsThe genetic, neurochemical and neuroimaging findings from various studies emphasize the complex role of the gene-environment interplay in the pathogenesis of violence and open a path of hope for the development and optimal timing of violence prevention strategies.
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Bondanelli, Marta, Maria Rosaria Ambrosio, Maria Chiara Zatelli, Laura De Marinis, and Ettore C. degli Uberti. "Hypopituitarism after traumatic brain injury." European Journal of Endocrinology 152, no. 5 (May 2005): 679–91. http://dx.doi.org/10.1530/eje.1.01895.
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Traumatic brain injury (TBI) is one of the main causes of death and disability in young adults, with consequences ranging from physical disabilities to long-term cognitive, behavioural, psychological and social defects. Post-traumatic hypopituitarism (PTHP) was recognized more than 80 years ago, but it was thought to be a rare occurrence. Recently, clinical evidence has demonstrated that TBI may frequently cause hypothalamic–pituitary dysfunction, probably contributing to a delayed or hampered recovery from TBI. Changes in pituitary hormone secretion may be observed during the acute phase post-TBI, representing part of the acute adaptive response to the injury. Moreover, diminished pituitary hormone secretion, caused by damage to the pituitary and/or hypothalamus, may occur at any time after TBI. PTHP is observed in about 40% of patients with a history of TBI, presenting as an isolated deficiency in most cases, and more rarely as complete pituitary failure. The most common alterations appear to be gonadotropin and somatotropin deficiency, followed by corticotropin and thyrotropin deficiency. Hyper- or hypoprolactinemia may also be present. Diabetes insipidus may be frequent in the early, acute phase post-TBI, but it is rarely permanent. Severity of TBI seems to be an important risk factor for developing PTHP; however, PTHP can also manifest after mild TBI. Accurate evaluation and long-term follow-up of all TBI patients are necessary in order to detect the occurrence of PTHP, regardless of clinical evidence for pituitary dysfunction. In order to improve outcome and quality of life of TBI patients, an adequate replacement therapy is of paramount importance.
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Pyatin, V., A. Kolsanov, N. Romanchuk, D. Romanov, Davydkin, A. Volobuev, I. Sirotko, and S. Bulgakova. "Bioinformatics and Artificial Intelligence: Gerontological and Geriatric Components Medical and Social Support for Active Healthy Longevity." Bulletin of Science and Practice 6, no. 12 (December 15, 2020): 155–75. http://dx.doi.org/10.33619/2414-2948/61/16.
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The “cognitive reserve” construct is a set of variables, including intelligence, education, and mental stimulation, that presumably allows the brain to adapt to underlying pathologies, supporting cognitive function despite underlying neural changes. Brain Homo Sapiens also points to resistance to neuropathological damage and can be defined as the ability to optimize or maximize performance through an effective set of neural networks and/or alternative cognitive strategies. Learning in childhood, the level of education and activities for adults — all this independently contributes to the formation of a cognitive reserve. The introduction of biocomputer nanoplatforms and modules consisting of small molecules, polymers, nucleic acids or proteins/peptides, nanoplatforms are programmed to detect and process external stimuli, such as magnetic fields or light, or internal stimuli, such as nucleic acids, enzymes or pH, using three different mechanisms: system assembly, system disassembly or system transformation. Current biocomputer nanoplatforms are invaluable for many applications, including medical diagnostics, biomedical imaging, environmental monitoring, and delivery of therapeutic drugs to target cell populations. The future implementation of systems biology and systems neurophysiology paradigms based on complex analysis of large and deep heterogeneous data sources will be crucial to achieve a deeper understanding of the pathophysiology of Alzheimer’s disease, using current brain-computer and artificial intelligence interface technologies, in order to increase information that can be extracted from preclinical and clinical indicators. Integration of different sources of information will allow researchers to obtain a new holistic picture of the pathophysiological process of the disease, which will cover from molecular changes to cognitive manifestations. The new competencies of psychoneuroimmunoendocrinology and psychoneuroimmunology play a strategic role in interdisciplinary science and interdisciplinary planning and decision-making. The introduction of multi-vector neurotechnologies of artificial intelligence and the principles of digital health care will contribute to the development of modern neuroscience and neuromarketing. Medical and social support for active healthy longevity is possible when synchronizing information systems of medical organizations and social institutions, introducing a single neurophysiological circuit and modern neurointerfaces, a combined and hybrid cluster in the diagnosis, treatment, prevention and rehabilitation of cognitive disorders and cognitive disorders. A key factor in medical and social support is the participation of interdisciplinary business employees and data processing specialists (their support, monitoring), as well as the availability of sufficient staff literacy in data management.
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Ward, Rosalind F., and Simon Manchip. "‘Inappropriate’ sexual behaviours in dementia." Reviews in Clinical Gerontology 23, no. 1 (December 14, 2012): 75–87. http://dx.doi.org/10.1017/s0959259812000196.
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SummaryHuman sexuality is a complex interaction of biological, social and emotional factors. When any or all of these factors are disrupted by a progressive dementia it is unsurprising that sexual ‘problems’ are identified. Most sexual behaviour ‘problems’ relate to expressions of normal sexuality complicated by changes in relationships, care needs and cognitive function, and complex ethical and legal considerations emerge. Rarely, new and severe hypersexual or paraphilic behaviours arise de novo, usually due to damage to certain brain areas, and sometimes due to medication side-effects, psychiatric disorder or delirium. Evidence and approaches to assess and to manage sexual behaviour problems in dementia are discussed.
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Bonfiglio, Tommaso, Matteo Vergassola, Guendalina Olivero, and Anna Pittaluga. "Environmental Training and Synaptic Functions in Young and Old Brain: A Presynaptic Perspective." Current Medicinal Chemistry 26, no. 20 (September 13, 2019): 3670–84. http://dx.doi.org/10.2174/0929867325666180228170450.
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Background:Aging is an unavoidable, physiological process that reduces the complexity and the plasticity of the synaptic contacts in Central Nervous System (CNS), having profound implications for human well-being. The term “cognitive reserve” refers to central cellular adaptations that augment the resilience of human brain to damage and aging. The term “Cognitive training” indicates the cultural, social and physical stimulations proposed as add-on therapy for the cure of central neurological diseases. “Cognitive training” reinforces the “cognitive reserve” permitting to counteract brain impairments and rejuvenating synaptic complexity. The research has begun investigating the clinical impact of the “cognitive training” in aged people, but additional work is needed to definitively assess its effectiveness. In particular, there is a need to understand, from a preclinical point of view, whether “cognitive training” promotes compensatory effects or, alternatively, if it elicits genuine recovery of neuronal defects. Although the translation from rodent studies to the clinical situation could be difficult, the results from pre-clinical models are of high clinical relevance, since they should allow a better understanding of the effects of environmental interventions in aging-associated chronic derangements in mammals.Conclusion:Data in literature and the recent results obtained in our laboratory concerning the impact of environmental stimulation on the presynaptic release of noradrenaline, glutamate and gamma amino butyric acid (GABA) suggest that these neurotransmitters undergo different adaptations during aging and that they are differently tuned by “cognitive training”. The impact of “cognitive training” on neurotransmitter exocytosis might account for the cellular events involved in reinforcement of “cognitive reserve” in young and old animals.
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Yin, Lu, and Shuang Yue Zhu. "A Study on the Influence of Cysteine and Magnesium Ions on Brain Dementia." Applied Mechanics and Materials 487 (January 2014): 161–64. http://dx.doi.org/10.4028/www.scientific.net/amm.487.161.
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As the population ages, dementia disease is increasingly becoming the most concerned social problems. According to the cause of dementia, it can be divided into many kinds class, among them with Alzheimer's Disease (Alzheimers diseases, AD) and Vascular Dementia (Vascular Dementia, VD) are common. Data shows it accounts for nearly 60% of total AD dementia patients, VD (20%), but only 2% of patients could get timely diagnosis and treatment, make its cognitive damage to a certain extent suppress and improve. for untimely diagnosis and treatment, most patients makes the disease development worse. In recent years, studies have shown that plasma Homocysteine,Hcy levels associated with AD. And studies show that from the power of the risk factors to the mechanism analysis, dementia disease level correlation with magnesium ions. On this basis, this study of plasma homocysteine in patients with AD,VD and magnesium ion detection results were analyzed retrospectively. Discuss their levels between the distributio relationship of patients ages in AD and VD.
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Konrad, C., A. J. Geburek, F. Rist, H. Blumenroth, B. Fischer, I. Husstedt, V. Arolt, H. Schiffbauer, and H. Lohmann. "Long-term cognitive and emotional consequences of mild traumatic brain injury." Psychological Medicine 41, no. 6 (September 22, 2010): 1197–211. http://dx.doi.org/10.1017/s0033291710001728.
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BackgroundThe objective of this study was to investigate long-term cognitive and emotional sequelae of mild traumatic brain injury (mTBI), as previous research has remained inconclusive with respect to their prevalence and extent.MethodThirty-three individuals who had sustained mTBI on average 6 years prior to the study and 33 healthy control subjects were matched according to age, gender and education. Structural brain damage at time of testing was excluded by magnetic resonance imaging (MRI). A comprehensive neuropsychological test battery was conducted to assess learning, recall, working memory, attention and executive function. Psychiatric symptoms were assessed by the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and the Beck Depression Inventory (BDI). Possible negative response bias was ruled out by implementing the Word Memory Test (WMT).ResultsThe mTBI individuals had significant impairments in all cognitive domains compared to the healthy control subjects. Effect sizes of cognitive deficits were medium to large, and could not be accounted for by self-perceived deficits, depression, compensation claims or negative response bias. BDI scores were significantly higher in the patient group, and three patients fulfilled DSM-IV criteria for a mild episode of major depression.ConclusionsPrimarily, well-recovered individuals who had sustained a minor trauma more than half a decade ago continue to have long-term cognitive and emotional sequelae relevant for everyday social and professional life. mTBI may lead to a lasting disruption of neurofunctional circuits not detectable by standard structural MRI and needs to be taken seriously in clinical and forensic evaluations.
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Smith, A., and A. Davis. "PGR - 1 A Pediatric Case Study of Autism Spectrum Disorder Associated with Germinal Matrix-Intraventricular Hemorrhage, Periventricular Leukomalacia, and Cerebral Palsy." Archives of Clinical Neuropsychology 34, no. 6 (July 25, 2019): 827. http://dx.doi.org/10.1093/arclin/acz036.01.
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Abstract Objective Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a serious complication of prematurity that places infants at risk for damage to important white matter pathways which can result in periventricular leukomalacia (PVL) and ultimately cerebral palsy (CP). GMH-IVH also increases the risk of developmental and intellectual disabilities for preterm infants, highlighting the need for early detection and treatment. Method This case study presents on the neuropsychological profile of a 4-year-old boy who was born micropremature and had a history of multiple hemorrhages, extensive PVL, and CP in the context of significant developmental and social delays. Results Neuropsychological testing revealed severe impairments in intellectual functioning (Stanford Binet-5 FSIQ = 42, Nonverbal IQ = 43, Verbal IQ = 47; Leiter-3 Nonverbal IQ = 41), adaptive skills, language, social cognition, visuomotor abilities, spatial skills, pre-academic skills, and attention/executive functioning. He scored in the significant range on measures specific to Autism Spectrum Disorder (ADOS-2; CARS-2; SCQ) and behavioral-emotional functioning. Lastly, he exhibited intermittent staring behaviors that were concerning for possible seizure activity. Conclusions Recommendations were made to increase special education services for the child and to modify his academic goals. Recommendations were also given to aid in treatment planning for his referring neurologist and clinical interventions (e.g., ABA, social work, speech/language, occupational therapy, and physical therapy). This case study demonstrates the need for early neuropsychological detection and treatment for children with complications of prematurity during this important period of brain development, particularly as there are higher rates of autism in this population. Prompt detection leads to earlier treatment and better outcomes.
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Looi, Dawn Shu Hui, Mark Sen Liang Goh, Sharon Si Min Goh, Jia Ling Goh, Rehena Sultana, Jan Hau Lee, and Shu-Ling Chong. "Protocol for a systematic review and meta-analysis of long-term neurocognitive outcomes in paediatric traumatic brain injury." BMJ Open 10, no. 6 (June 2020): e035513. http://dx.doi.org/10.1136/bmjopen-2019-035513.
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IntroductionChildren who suffer from traumatic brain injury (TBI) are at risk of permanent brain damage and developmental deficits. Reports on neurodevelopmental outcomes in paediatric TBI suffer from small sample size and varying outcome definitions in the neurocognitive domains tested. This protocol describes a systematic review and meta-analysis of paediatric TBI in the following key neurocognitive domains: executive function, perceptual–motor function, language, learning and memory, social cognition and complex attention.MethodsA comprehensive search comprising studies from Medline, Cochrane, Embase and PsycINFO published from 1988 to 2019 will be conducted. We will include studies on children ≤18 years old who suffer from mild, moderate and severe TBI as determined by the Glasgow Coma Scale that report neurocognitive outcomes in domains predetermined by the Diagnostic and Statistical Manual of Mental Disorders fifth edition criteria. Systematic reviews, meta-analyses, randomised controlled trials, case–control, cohort and cross-sectional studies will be included. References from systematic reviews and meta-analyses will be hand-searched for relevant articles. A meta-analysis will be performed and effect sizes will be calculated to summarise the magnitude of change in each neurocognitive domain compared at different timepoints and stratified by severity of TBI. Included studies will be pooled using pooled standardised mean differences with a random effects model to determine an overall effect. In the scenario that we are unable to pool the studies, we will perform a narrative analysis.Ethics and disseminationEthics approval is not required for this study.The authors of this study will publish and present the findings in a peer-reviewed journal as well as national and international conferences. The results of this study will provide understanding into the association between different severities of paediatric TBI and long-term neurocognitive outcomes.PROSPERO registration numberCRD42020152680.
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Thomas, Bradley C., Katie E. Croft, and Daniel Tranel. "Harming Kin to Save Strangers: Further Evidence for Abnormally Utilitarian Moral Judgments after Ventromedial Prefrontal Damage." Journal of Cognitive Neuroscience 23, no. 9 (September 2011): 2186–96. http://dx.doi.org/10.1162/jocn.2010.21591.
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The ventromedial PFC (vmPFC) has been implicated as a critical neural substrate mediating the influence of emotion on moral reasoning. It has been shown that the vmPFC is especially important for making moral judgments about “high-conflict” moral dilemmas involving direct personal actions, that is, scenarios that pit compelling utilitarian considerations of aggregate welfare against the highly emotionally aversive act of directly causing harm to others [Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., et al. Damage to the prefrontal cortex increases utilitarian moral judgments. Nature, 446, 908–911, 2007]. The current study was designed to elucidate further the role of the vmPFC in high-conflict moral judgments, including those that involve indirect personal actions, such as indirectly causing harm to one's kin to save a group of strangers. We found that patients with vmPFC lesions were more likely than brain-damaged and healthy comparison participants to endorse utilitarian outcomes on high-conflict dilemmas regardless of whether the dilemmas (1) entailed direct versus indirect personal harms and (2) were presented from the Self versus Other perspective. In addition, all groups were more likely to endorse utilitarian outcomes in the Other perspective as compared with the Self perspective. These results provide important extensions of previous work, and the findings align with the proposal that the vmPFC is critical for reasoning about moral dilemmas in which anticipating the social-emotional consequences of an action (e.g., guilt or remorse) is crucial for normal moral judgments [Greene, J. D. Why are VMPFC patients more utilitarian?: A dual-process theory of moral judgment explains. Trends in Cognitive Sciences, 11, 322–323, 2007; Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., et al. Damage to the prefrontal cortex increases utilitarian moral judgments. Nature, 446, 908–911, 2007].
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Glushakov, Andriy, Olena Glushakova, Tetyana Korol, Sandra Acosta, Cesar Borlongan, Alex Valadka, Ronald Hayes, and Alexander Glushakov. "Chronic Upregulation of Cleaved-Caspase-3 Associated with Chronic Myelin Pathology and Microvascular Reorganization in the Thalamus after Traumatic Brain Injury in Rats." International Journal of Molecular Sciences 19, no. 10 (October 13, 2018): 3151. http://dx.doi.org/10.3390/ijms19103151.
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Traumatic brain injury (TBI) is associated with long-term disabilities and devastating chronic neurological complications including problems with cognition, motor function, sensory processing, as well as behavioral deficits and mental health problems such as anxiety, depression, personality change and social unsuitability. Clinical data suggest that disruption of the thalamo-cortical system including anatomical and metabolic changes in the thalamus following TBI might be responsible for some chronic neurological deficits following brain trauma. Detailed mechanisms of these pathological processes are not completely understood. The goal of this study was to evaluate changes in the thalamus following TBI focusing on cleaved-caspase-3, a specific effector of caspase pathway activation and myelin and microvascular pathologies using immuno- and histochemistry at different time points from 24 h to 3 months after controlled cortical impact (CCI) in adult Sprague-Dawley rats. Significant increases in cleaved-caspase-3 immunoreactivity in the thalamus were observed starting one month and persisting for at least three months following experimental TBI. Further, the study demonstrated an association of cleaved-caspase-3 with the demyelination of neuronal processes and tissue degeneration in the gray matter in the thalamus, as reflected in alterations of myelinated fiber integrity (luxol fast blue) and decreases in myelin basic protein (MBP) immunoreactivity. The immunofluorescent counterstaining of cleaved-caspase-3 with endothelial barrier antigen (EBA), a marker of blood-brain barrier, revealed limited direct and indirect associations of cleaved caspase-3 with blood-brain barrier damage. These results demonstrate for the first time a significant chronic upregulation of cleaved-caspase-3 in selected thalamic regions associated with cortical regions directly affected by CCI injury. Further, our study is also the first to report that significant upregulation of cleaved-caspase-3 in selected ipsilateral thalamic regions is associated with microvascular reorganization reflected in the significant increases in the number of microvessels with blood-brain barrier alterations detected by EBA staining. These findings provide new insights into potential mechanisms of TBI cell death involving chronic activation of caspase-3 associated with disrupted cortico-thalamic and thalamo-cortical connectivity. Moreover, this study offers the initial evidence that this upregulation of activated caspase-3, delayed degeneration of myelinated nerve fibers and microvascular reorganization with impaired blood-brain barrier integrity in the thalamus might represent reciprocal pathological processes affecting neuronal networks and brain function at the chronic stages of TBI.
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Conway, Martin A., Catherine Loveday, and Scott N. Cole. "The remembering–imagining system." Memory Studies 9, no. 3 (July 2016): 256–65. http://dx.doi.org/10.1177/1750698016645231.
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Remembering and imagining are intricately related, particularly in imagining the future: episodic future thinking. It is proposed that remembering the recent past and imagining the near future take place in what we term the remembering–imagining system. The remembering–imagining system renders recently formed episodic memories and episodic imagined near-future events highly accessible. We suggest that this serves the purpose of integrating past, current, and future goal-related activities. When the remembering–imagining system is compromised, following brain damage and in psychological illnesses, the future cannot be effectively imagined and episodic future thinking may become dominated by dysfunctional images of the future.
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Wilmer, Jeremy B. "Individual Differences in Face Recognition: A Decade of Discovery." Current Directions in Psychological Science 26, no. 3 (June 2017): 225–30. http://dx.doi.org/10.1177/0963721417710693.
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Given the vital role face recognition plays in human social interaction, variations in this ability hold inherent interest and potential consequence. Yet the science of such differences has long lagged behind that of differences in other cognitive domains. In particular, although scattered case reports of catastrophic face-recognition deficits due to brain damage date back more than a century, for many decades, virtually no attention was paid to naturally occurring individual differences in face recognition. This past decade, in contrast, has seen a remarkable acceleration of research into these naturally occurring differences, spurred by the creation and validation of high-quality measures, open sharing of these measures, new options for remote testing, and a concerted move toward larger and more multivariate investigations. In this article, I recount six fundamental insights gained during the past decade about individual differences in face recognition—concerning their broad range, cognitive specificity, strong heritability, resilience to change, life-span trajectory, and practical relevance. Insights like these support a richer understanding of individual social experience and could enable more informed individual and institutional decision making.
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Guilmette, Thomas J., Kathleen J. Hast, William M. Whelihan, Frank R. Sparadeo, and Gregg Buongiorno. "Order Effects in the Administration of a Forced-Choice Procedure for Detection of Malingering in Disability Claimants' Evaluations." Perceptual and Motor Skills 83, no. 3 (December 1996): 1007–16. http://dx.doi.org/10.2466/pms.1996.83.3.1007.
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100 disability claimants of the Social Security Administration referred for neuropsychological evaluation and 40 undergraduate college students asked to simulate brain damage were administered a measure for the detection of malingering, an abbreviated version of the Hiscock Forced-choice Procedure, and other neuropsychological tests. Half of each group was administered the Hiscock Procedure at the beginning of the battery; the other half was administered this test last. For both groups, the results indicated poorer performance on the earlier administration of the abbreviated Hiscock Forced-choice Procedure. Formal measures for detection of malingering should be an integral and early part of any neuropsychological evaluation in which the subject has a financial incentive to perform poorly.