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1

Margha, Fatma, and Amr Abdelghany. "Bone bonding ability of some borate bio-glasses and their corresponding glass-ceramic derivatives." Processing and Application of Ceramics 6, no. 4 (2012): 183–92. http://dx.doi.org/10.2298/pac1204183m.

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Ternary borate glasses from the system Na2O?CaO?B2O3 together with soda-lime-borate samples containing 5 wt.% of MgO, Al2O3, SiO2 or P2O5 were prepared. The obtained glasses were converted to their glass-ceramic derivatives by controlled heat treatment. X-ray diffraction was employed to investigate the separated crys?talline phases in glass-ceramics after heat treatment of the glassy samples. The glasses and corresponding glass-ceramics after immersion in water or diluted phosphate solution for extended times were characterized by the grain method (adopted by several authors and recommended by
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2

Marzouk, Mohamed, and Batal El. "In vitro bioactivity of soda lime borate glasses with substituted SrO in sodium phosphate solution." Processing and Application of Ceramics 8, no. 3 (2014): 167–77. http://dx.doi.org/10.2298/pac1403167m.

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Borate glasses with the basic composition 0.6B2O3?0.2Na2O?0.2CaO and SrO progressively substituting CaO were prepared and characterized for their bone-bonding ability. The obtained glasses were thermally treated and converted to their glass-ceramic derivatives. In this study, FTIR spectral analyses were done for the prepared glasses and glass-ceramics before and after immersion in a sodium phosphate solution for extended times. The appearance of two IR bands within the spectral range 550-680 cm-1 after immersion confirms the formation of hydroxyapatite. X-ray diffraction studies and scanning e
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3

Buonsante, P., F. Massel, V. Penna, and A. Vezzani. "Glassy features of a Bose glass." Laser Physics 18, no. 5 (2008): 653–58. http://dx.doi.org/10.1134/s1054660x08050174.

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4

Burdușel, Alexandra-Cristina. "Bioactive composites for bone regeneration." Biomedical Engineering International 1, no. 1 (2019): 9–15. http://dx.doi.org/10.33263/biomed11.009015.

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Bone, the organ that separates vertebrates from other living beings, is a complex tissue responsible of mobility, body stability, organ protection, and metabolic activities such as ion storage. Ceramic materials are appropriate candidates to be used in the fabrication of scaffolds for bone healing. Biocompatible ceramic materials may also be created to deliver biologically active substances aimed at maintaining, repairing, restoring, or boosting the function of tissues and organs in the organism. Glass-ceramic materials furnish flexible properties appropriate for some particular applications.
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5

Lee, Sungho, Fukue Nagata, Katsuya Kato, Takayoshi Nakano, and Toshihiro Kasuga. "Structures and Dissolution Behaviors of Quaternary CaO-SrO-P2O5-TiO2 Glasses." Materials 14, no. 7 (2021): 1736. http://dx.doi.org/10.3390/ma14071736.

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Calcium phosphate glasses have a high potential for use as biomaterials because their composition is similar to that of the mineral phase of bone. Phosphate glasses can dissolve completely in aqueous solution and can contain various elements owing to their acidity. Thus, the glass can be a candidate for therapeutic ion carriers. Recently, we focused on the effect of strontium ions for bone formation, which exhibited dual effects of stimulating bone formation and inhibiting bone resorption. However, large amounts of strontium ions may induce a cytotoxic effect, and there is a need to control th
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6

Wetzel, Roland, Leena Hupa, and Delia S. Brauer. "Glass ionomer bone cements based on magnesium-containing bioactive glasses." Biomedical Glasses 5, no. 1 (2019): 1–12. http://dx.doi.org/10.1515/bglass-2019-0001.

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Abstract Glass ionomer cements (GIC) are used in restorative dentistry and their properties (low heat during setting, adhesion to mineralised tissue and surgical metals) make them of great interest for bone applications.However, dental GIC are based on aluminium-containing glasses, and the resulting release of aluminium ions from the cements needs to be avoided for applications as bone cements. Replacing aluminium ions in glasses for use in glass ionomer cements is challenging, as aluminium ions play a critical role in the required glass degradation by acid attack as well as in GIC mechanical
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7

Brauer, Delia S., Natalia Karpukhina, Daphne Seah, Robert V. Law, and Robert G. Hill. "Fluoride-Containing Bioactive Glasses." Advanced Materials Research 39-40 (April 2008): 299–304. http://dx.doi.org/10.4028/www.scientific.net/amr.39-40.299.

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Fluoride is an important mineral for hard tissues in the body and appropriate fluoride exposure and usage are beneficial to bone and tooth integrity. Fluoride increases both bone density and bone mass due to stimulation of bone formation and it is used as a treatment for osteoporosis. Bioactive glasses have the capacity to form an intimate bond with living bone tissue due to formation of a mixed hydroxycarbonate apatite layer (HCA) in vitro and in vivo. This makes fluoride-containing bioactive glasses attractive biomaterials. In order to design fluoride-containing bioactive glasses, we need to
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8

Dukle, Amey, Dhanashree Murugan, Arputharaj Joseph Nathanael, Loganathan Rangasamy, and Tae-Hwan Oh. "Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?" Polymers 14, no. 8 (2022): 1627. http://dx.doi.org/10.3390/polym14081627.

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According to the Global Burden of Diseases, Injuries, and Risk Factors Study, cases of bone fracture or injury have increased to 33.4% in the past two decades. Bone-related injuries affect both physical and mental health and increase the morbidity rate. Biopolymers, metals, ceramics, and various biomaterials have been used to synthesize bone implants. Among these, bioactive glasses are one of the most biomimetic materials for human bones. They provide good mechanical properties, biocompatibility, and osteointegrative properties. Owing to these properties, various composites of bioactive glasse
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9

Ben-Arfa, Basam A. E., and Robert C. Pullar. "A Comparison of Bioactive Glass Scaffolds Fabricated ‎by Robocasting from Powders Made by Sol–Gel and Melt-Quenching Methods." Processes 8, no. 5 (2020): 615. http://dx.doi.org/10.3390/pr8050615.

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Bioactive glass scaffolds are used in bone and tissue biomedical implants, and there is great interest in their fabrication by additive manufacturing/3D printing techniques, such as robocasting. Scaffolds need to be macroporous with voids ≥100 m to allow cell growth and vascularization, biocompatible and bioactive, with mechanical properties matching the host tissue (cancellous bone for bone implants), and able to dissolve/resorb over time. Most bioactive glasses are based on silica to form the glass network, with calcium and phosphorous content for new bone growth, and a glass modifier such
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10

Navarro, Melba, E. S. Sanzana, Josep A. Planell, M. P. Ginebra, and P. A. Torres. "In Vivo Behavior of Calcium Phosphate Glasses with Controlled Solubility." Key Engineering Materials 284-286 (April 2005): 893–96. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.893.

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Resorbable calcium phosphate glasses offer interesting solutions in the biomedical field, as bone cavity fillers, drug delivery systems, biodegradable reinforcing phase in the case of composites for bone fixation devices and tissue engineering scaffolds. In this work, two different glass formulations in the systems 44.5CaO-44.5P2O5-(11-X)Na2O-XTiO2 (X=0or 5) have been elaborated. It is known that the incorporation or TiO2 into the vitreous system reduces considerably the solubility of the glasses. To study the material solubility effect on the in vivo response, glass particles of the two formu
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11

Fredholm, Yann C., Natalia Karpukhina, Delia S. Brauer, Julian R. Jones, Robert V. Law, and Robert G. Hill. "Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation." Journal of The Royal Society Interface 9, no. 70 (2011): 880–89. http://dx.doi.org/10.1098/rsif.2011.0387.

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Bioactive glasses are able to bond to bone through the formation of hydroxy-carbonate apatite in body fluids while strontium (Sr)-releasing bioactive glasses are of interest for patients suffering from osteoporosis, as Sr was shown to increase bone formation both in vitro and in vivo . A melt-derived glass series (SiO 2 –P 2 O 5 –CaO–Na 2 O) with 0–100% of calcium (Ca) replaced by Sr on a molar base was prepared. pH change, ion release and apatite formation during immersion of glass powder in simulated body fluid and Tris buffer at 37°C over up to 8 h were investigated and showed that substitu
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12

Beltrán, Ana M., Paloma Trueba, Flora Borie, et al. "Bioactive Bilayer Glass Coating on Porous Titanium Substrates with Enhanced Biofunctional and Tribomechanical Behavior." Coatings 12, no. 2 (2022): 245. http://dx.doi.org/10.3390/coatings12020245.

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The use of porous titanium samples fabricated by space-holder powder metallurgy with bioactive coatings has already been reported to prevent resorption of the bone surrounding the implant and improve osseointegration, respectively. However, the presence of pores as well as the poor adherence and the brittle behavior inherent to glassy coatings affect the service behavior of implants fabricated from these samples. Therefore, they need to be optimized. In this work, 50 vol.% of porosity titanium substrates were manufactured with different pore range size (100–200 and 355–500 µm) spacer particles
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13

Maximov, Maxim, Oana-Cristina Maximov, Luminita Craciun, Denisa Ficai, Anton Ficai, and Ecaterina Andronescu. "Bioactive Glass—An Extensive Study of the Preparation and Coating Methods." Coatings 11, no. 11 (2021): 1386. http://dx.doi.org/10.3390/coatings11111386.

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Diseases or complications that are caused by bone tissue damage affect millions of patients every year. Orthopedic and dental implants have become important treatment options for replacing and repairing missing or damaged parts of bones and teeth. In order to use a material in the manufacture of implants, the material must meet several requirements, such as mechanical stability, elasticity, biocompatibility, hydrophilicity, corrosion resistance, and non-toxicity. In the 1970s, a biocompatible glassy material called bioactive glass was discovered. At a later time, several glass materials with s
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14

Liang, Wen, Christian Rüssel, Delbert E. Day, and Günter Völksch. "Bioactive comparison of a borate, phosphate and silicate glass." Journal of Materials Research 21, no. 1 (2006): 125–31. http://dx.doi.org/10.1557/jmr.2006.0025.

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A borate glass, phosphate glass, and silicate glass were converted to hydroxyapatite (HA) by soaking the substrates in a solution of K2HPO4 with a pH value of 9.0 at 37 °C. The weight loss of the substrates was studied as a function of time. Unlike the silicate glasses, the reaction processes of the borate glasses and phosphate glasses were bulk dissolution. X-ray diffraction and scanning electron microscopy revealed an initially amorphous product that subsequently crystallized to HA. The data suggest good bioactive characteristics for the borate and phosphate glass and the potential use of th
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15

Abdelghany, Amr, Fatema Elbatal, and Hatem Elbatal. "Zinc containing borate glasses and glass-ceramics: Search for biomedical applications." Processing and Application of Ceramics 8, no. 4 (2014): 185–93. http://dx.doi.org/10.2298/pac1404185a.

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Ternary soda lime borate glass and samples with ZnO replacing CaO up to 10mol%were prepared and studied for their bone bonding ability. Fourier transform infrared (FTIR) absorption spectra of the prepared glasses before and after immersion in simulated body fluid (SBF), for one or two weeks, showed the appearance of calcium phosphate (hydroxyapatite (HA)) which is an indication of bone bonding ability. X-ray diffraction patterns were measured for the glasses and indicated the presence of small peaks related to hydroxyapatite in the samples immersed in SBF. The glasses were heat treated with co
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16

Kargozar, Saeid, Francesco Baino, Sara Banijamali, and Masoud Mozafari. "Synthesis and physico-chemical characterization of fluoride (F)- and silver (Ag)-substituted sol-gel mesoporous bioactive glasses." Biomedical Glasses 5, no. 1 (2019): 185–92. http://dx.doi.org/10.1515/bglass-2019-0015.

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Abstract Synthesis and use of novel compositions of bioactive glasses (BGs) for hard tissue engineering are of important significance in the biomedical field. In this study, we successfully synthesized a series of 58S-based BGs containing fluoride (F−) and silver (Ag+) ions through a sol-gel method for possible use in bone/dental regeneration and antibacterial strategies. Characterizations of samples were performed by using thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), te
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17

Goodridge, Ruth D., Chikara Ohtsuki, Masanobu Kamitakahara, David J. Wood, and Kenny W. Dalgarno. "Fabrication of Bioactive Glass-Ceramics by Selective Laser Sintering." Key Engineering Materials 309-311 (May 2006): 289–92. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.289.

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The feasibility of processing glass-ceramics using the layer manufacturing technique, selective laser sintering (SLS), to produce parts with suitable biological and mechanical properties for use in bone replacement applications, has been investigated. Glass-ceramics derived from glasses based on several different systems have been considered. Initial experiments using an apatite-mullite glass-ceramic (4.5SiO2⋅3Al203⋅1.6P2O5⋅3CaO⋅2CaF2) demonstrated the ability to process glass-ceramic materials using this technique, creating parts with a strength similar to that of cancellous bone, and a porou
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18

Zambanini, Telma, Roger Borges, Ana C. S. de Souza, et al. "Holmium-Containing Bioactive Glasses Dispersed in Poloxamer 407 Hydrogel as a Theragenerative Composite for Bone Cancer Treatment." Materials 14, no. 6 (2021): 1459. http://dx.doi.org/10.3390/ma14061459.

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Holmium-containing bioactive glasses can be applied in bone cancer treatment because the holmium content can be neutron activated, having suitable properties for brachytherapy applications, while the bioactive glass matrix can regenerate the bone alterations induced by the tumor. To facilitate the application of these glasses in clinical practice, we proposed a composite based on Poloxamer 407 thermoresponsive hydrogel, with suitable properties for applications as injectable systems. Therefore, in this work, we evaluated the influence of holmium-containing glass particles on the properties of
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19

Boonyang, U., F. Li, and A. Stein. "Hierarchical Structures and Shaped Particles of Bioactive Glass and ItsIn VitroBioactivity." Journal of Nanomaterials 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/681391.

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In this study, bioactive glass particles with controllable structure and porosity were prepared using dual-templating methods. Block copolymers used as one template component produced mesopores in the calcined samples. Polymer colloidal crystals as the other template component yielded either three-dimensionally ordered macroporous (3DOM) products or shaped bioactive glass nanoparticles. Thein vitrobioactivity of these bioactive glasses was studied by soaking the samples in simulated body fluid (SBF) at body temperature (37°C) for varying lengths of time and monitoring the formation of bone-lik
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20

Chen, Chuan Zhong, Xiang Guo Meng, Hui Jun Yu, et al. "Research Progress in Bioactive Glasses for Implant Materials." Key Engineering Materials 591 (November 2013): 108–12. http://dx.doi.org/10.4028/www.scientific.net/kem.591.108.

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With the constant development of medical technology, biological materials become more and more important in surgical repair. Bioactive glass and glass ceramic, because of the good bioactivity and biocompatibility, are considered to be the most ideal material for bone repair and replacement. Thus in this paper the recent research progress in bioactive glasses and glass ceramics are summarized. The characteristics of component, structure and property of several kinds of bioactive glasses and glass ceramics are analyzed, the existent problems and some different solutions are also discussed, and t
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Trambitas, Cristian, Tudor Sorin Pop, Alina Dia Trambitas Miron, Dorin Constantin Dorobantu, and Klara Brinzaniuc. "S53P4 Bioactive Glass - an Alternative Treatment of Bone Defects." Revista de Chimie 68, no. 2 (2017): 387–89. http://dx.doi.org/10.37358/rc.17.2.5459.

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A challenging problem in orthopedic practice is represented by bone defects may they occur from trauma, malignancy, infection or congenital disease. Bioactive Glasses have a widely recognized ability to foster the growth of bone cells, and to bond strongly with both hard and soft tissues. Upon implantation, Bioactive Glasses undergoes specific reactions, leading to the formation of an amorphous calcium phosphate or crystalline hydroxyapatite phase on the surface of the glass, which is responsible for its strong bonding with the surrounding tissue. This phenomenon sustains a more rapid healing
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22

Majhi, M. R., R. Kumar, S. P. Singh, and R. Pyare. "Physico-Chemical Properties and Characterization of CaO-Fe2O3-P2O5 Glass as a Bioactive Ceramic Material." Journal of Biomimetics, Biomaterials and Tissue Engineering 12 (February 2012): 1–24. http://dx.doi.org/10.4028/www.scientific.net/jbbte.12.1.

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The Aim of this Work Is to Investigate Role of Iron in Calcium-Iron-Phosphate Bioglass. the Density, Compressive Strength, Tg Point and Leachability of Cations Were Measured. the Ph Behaviour of Simulated Body Fluid after Soaking Phosphate Glasses for Different Time Periods Were Also Studied and it Was Observed that Higher Phosphate Glasses Containing Lower Lime Possessed Better Bioactivity than Lower Phosphate Glasses Containing More Iron and Lime Contents. the DTA and FTIR Spectrometry of Glasses Were Performed. the Absorption Spectra Showed that Iron Was Present in the Glass only as Fe3+ Io
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Zhang, Xuanyu, Minhui Zhang, and Jian Lin. "Effect of pH on the In Vitro Degradation of Borosilicate Bioactive Glass and Its Modulation by Direct Current Electric Field." Materials 15, no. 19 (2022): 7015. http://dx.doi.org/10.3390/ma15197015.

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Controlled ion release and mineralization of bioactive glasses are essential to their applications in bone regeneration. Tuning the chemical composition and surface structure of glasses are the primary means of achieving this goal. However, most bioactive glasses exhibit a non-linear ion release behavior. Therefore, modifying the immersion environment of glasses through external stimuli becomes an approach. In this study, the ion release and mineralization properties of a borosilicate bioactive glass were investigated in the Tris buffer and K2HPO4 solutions with different pH. The glass had a f
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Bellucci, Devis, Valeria Cannillo, Alexandre Anesi, et al. "Bone Regeneration by Novel Bioactive Glasses Containing Strontium and/or Magnesium: A Preliminary In-Vivo Study." Materials 11, no. 11 (2018): 2223. http://dx.doi.org/10.3390/ma11112223.

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In this work, a set of novel bioactive glasses have been tested in vivo in an animal model. The new compositions, characterized by an exceptional thermal stability and high in vitro bioactivity, contain strontium and/or magnesium, whose biological benefits are well documented in the literature. To simulate a long-term implant and to study the effect of the complete dissolution of glasses, samples were implanted in the mid-shaft of rabbits’ femur and analyzed 60 days after the surgery; such samples were in undersized powder form. The statistical significance with respect to the type of bioactiv
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Ju, Yin Yan, Qiang Li, Wang Nian Zhang, and Xiao Feng Chen. "Effect of the Additive 45S5 on the Properties of Bioactive Glass Scaffold Materials." Advanced Materials Research 1004-1005 (August 2014): 941–46. http://dx.doi.org/10.4028/www.scientific.net/amr.1004-1005.941.

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The bioactive glasses 58S was first prepared using sol-gel technique and the 45S5 bioactive glass was prepared through melting method. The above bioactive glasses were then grounded into fine powders, and each of the glass powders and their mixtures was doped with the porogen in certain ratios respectively. The bioactive porous materials were finally produced through sintering. We investigated the microstructure, surface morphologies, bending strength and bioactivity of the porous materials via in vitro method combined with DTA, SEM and FTIR techniques. The results show that the porous materia
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Singh, Dalveer, Sandeep Singh, and Gurpreet Singh. "Fabrication and Characterization of Bioglass." Asian Journal of Engineering and Applied Technology 7, no. 2 (2018): 99–102. http://dx.doi.org/10.51983/ajeat-2018.7.2.946.

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Glasses are common in use now days. These are used in different applications like domestic, automobile, telecommunication etc. The glasses are very useful materials because of their impressive properties. Few years back a new generation of glasses were developed i.e. bioactive glasses and bioactive glass ceramics. The glasses are used for bone grafting now-a-days because of their impressive bioactive properties. These glasses have tendency to form bonds with the living tissue organs. The future of these glasses will be bright in dental, orthopedics and prosthetic applications. In the present w
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Dixit, Kartikeya, and Niraj Sinha. "Effects of Boron Oxide Concentration and Carbon Nanotubes Reinforcement on Bioactive Glass Scaffolds for Bone Tissue Engineering." Journal of Nanoscience and Nanotechnology 21, no. 10 (2021): 5026–35. http://dx.doi.org/10.1166/jnn.2021.19370.

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In this work, the effect of varying content of B2O3 with respect to SiO2 on mechanical and bioactivity properties have been evaluated for borosilicate bioactive glasses containing SiO2, B2O3, CaO and P2O5. The bioactive glasses have been synthesized using the sol–gel technique. The synthesized glasses were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and Field Emission Scanning electron microscopy (FESEM). These bioactive glasses were fabricated as scaffolds by using polymer foam replication method. Subsequently, in vitro bioactivity evaluation of bo
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Imran, Zonera. "Bioactive Glass: A Material for the Future." World Journal of Dentistry 3, no. 2 (2012): 199–201. http://dx.doi.org/10.5005/jp-journals-10015-1156.

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ABSTRACT Bioactive glasses are novel dental materials that are different from conventional glasses and are used in dentistry. Bioactive glasses are composed of calcium and phosphate which are present in a proportion that is similar to the bone hydroxyapatite. These glasses bond to the tissue and are biocompatible. They have a wide range of medical and dental applications and are currently used as bone grafts, scaffolds and coating material for dental implants. This article reviews various properties of bioactive glasses and their applications and also reviews the changes that can be made in th
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Thonglem, S., Sukum Eitssayeam, Gobwute Rujijanagul, Tawee Tunkasiri, Kamonpan Pengpat, and A. Munpakdee. "Fabrication of P2O5-CaO-Na2O Glasses Doped with Zinc Oxide for Artificial Bone Applications." Advanced Materials Research 506 (April 2012): 509–12. http://dx.doi.org/10.4028/www.scientific.net/amr.506.509.

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The purpose of this work was to study the effect of ZnO on properties of P2O5-CaO-Na2O glass system for bone substituting applications. The glass formula used in this study is 45P2O5- (30-x)CaO - 25Na2O - xZnO where x = 0, 1 , 3, and 5 mol%. The corresponding glasses were prepared by conventional glass melting technique at 1000 °C for 1 h. Thermal parameters of each glass were studied by differential thermal analysis (DTA). These glasses were investigated in terms of infrared spectra and in vitro bioactivity. DTA results gave the glass transition temperatures in a range 227-280°C and crystalli
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Al-Harbi, Nuha, Hiba Mohammed, Yas Al-Hadeethi, et al. "Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review." Pharmaceuticals 14, no. 2 (2021): 75. http://dx.doi.org/10.3390/ph14020075.

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Regenerative medicine is a field that aims to influence and improvise the processes of tissue repair and restoration and to assist the body to heal and recover. In the field of hard tissue regeneration, bio-inert materials are being predominantly used, and there is a necessity to use bioactive materials that can help in better tissue–implant interactions and facilitate the healing and regeneration process. One such bioactive material that is being focused upon and studied extensively in the past few decades is bioactive glass (BG). The original bioactive glass (45S5) is composed of silicon dio
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Costa, Hermes S., Alexandra A. P. Mansur, Edel Figueiredo Barbosa-Stancioli, Marivalda Pereira, and Herman S. Mansur. "Hybrid Bioactive Glass-Polyvinyl Alcohol Prepared by Sol-Gel." Materials Science Forum 587-588 (June 2008): 62–66. http://dx.doi.org/10.4028/www.scientific.net/msf.587-588.62.

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Bioactive glasses are materials that have been used for the repair and reconstruction of diseased bone tissues, as they exhibit direct bonding with human bone tissues. However, bioactive glasses have low mechanical properties compared to cortical and cancellous bone. On the other hand, composite materials of biodegradable polymers with inorganic bioactive glasses are of particular interest to engineered scaffolds because they often show an excellent balance between strength and toughness and usually improved characteristics compared to their individual components. Composite bioactive glass-pol
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Mohan Babu, M., P. Syam Prasad, P. Venkateswara Rao, et al. "Influence of ZrO2 Addition on Structural and Biological Activity of Phosphate Glasses for Bone Regeneration." Materials 13, no. 18 (2020): 4058. http://dx.doi.org/10.3390/ma13184058.

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Zirconium doped calcium phosphate-based bioglasses are the most prominent bioactive materials for bone and dental repair and regeneration implants. In the present study, a 8ZnO–22Na2O–(24 − x)CaO–46P2O5–xZrO2 (0.1 ≤ x ≤ 0.7, all are in mol%) bioglass system was synthesized by the conventional melt-quenching process at 1100 °C. The glass-forming ability and thermal stability of the glasses were determined by measuring the glass transition temperature (Tg), crystallization temperature (Tc), and melting temperature (Tm), using differential thermal analysis (DTA). The biological activity of the pr
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33

Savvova, Oksana. "Biocide Apatite Glass-Ceramic Materials for Bone Endoprosthetics." Chemistry & Chemical Technology 7, no. 1 (2013): 109–12. http://dx.doi.org/10.23939/chcht07.01.109.

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Nicholson, John W. "Periodontal Therapy Using Bioactive Glasses: A Review." Prosthesis 4, no. 4 (2022): 648–63. http://dx.doi.org/10.3390/prosthesis4040052.

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This paper reviews the use of bioactive glasses as materials for periodontal repair. Periodontal disease causes bone loss, resulting in tooth loosening and eventual tooth loss. However, it can be reversed using bioactive glass, typically the original 45S5 formulation (Bioglass®) at the defect site. This is done either by plcing bioactive glass granules or a bioactive glass putty at the defect. This stimulates bone repair and causes the defect to disappear. Another use of bioactive glass in periodontics is to repair so-called furcation defects, i.e., bone loss due to infection at the intersecti
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Jones, Julian R., T. F. Kemp, and M. E. Smith. "Effect of OH Content on the Bioactivity of Sol-Gel Derived Glass Foam Scaffolds." Key Engineering Materials 309-311 (May 2006): 1031–34. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.1031.

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Bioactive glass scaffolds have been developed with interconnected macropore networks, with pore diameters in excess of 500µm and apertures in excess of 100µm, by foaming sol-gel derived bioactive glasses. Bioactive glasses bond to bone by forming a hydroxycarbonate apatite (HCA) layer on their surface on contact with body fluid, which is similar to the composition of the apatite in bone. The aim of this work was to investigate the how changing the atomic structure of the glass affects HCA layer formation. Scaffolds were synthesised at 3 sintering temperatures and were characterised using 29Si
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Zhang, Di, Hanna Arstila, Erik Vedel, Heimo O. Ylänen, Leena Hupa, and Mikko Hupa. "In Vitro Behavior of Fiber Bundles and Particles of Bioactive Glasses." Key Engineering Materials 361-363 (November 2007): 225–28. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.225.

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In vitro reactions of bundles of fibers with diameters 20-500 μm and crushed glasses of fractions 500-800 μm were compared with the reactions of plates of the same bioactive glasses. The samples were immersed in simulated body fluid (SBF) for 2-7 days. After immersion the changes on the surfaces of the samples were observed by SEM/EDXA. Layer formation on the glass surface was found to vary with glass composition, sample shape and local condition of single particle/fiber. However, only some fibers or particles formed similar in vitro reaction layers as the plates. The product form did not chan
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Eichhorn, Julia, Cindy Elschner, Martin Groß, et al. "Spinning of Endless Bioactive Silicate Glass Fibres for Fibre Reinforcement Applications." Applied Sciences 11, no. 17 (2021): 7927. http://dx.doi.org/10.3390/app11177927.

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Bioactive glasses have been used for many years in the human body as bone substitute. Since bioactive glasses are not readily available in the form of endless thin fibres with diameters below 20 µm, their use is limited to mainly non-load-bearing applications in the form of particles or granules. In this study, the spinnability of four bioactive silicate glasses was evaluated in terms of crystallisation behaviour, characteristic processing temperatures and viscosity determined by thermal analysis. The glass melts were drawn into fibres and their mechanical strength was measured by single fibre
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Lopes, P. P., B. J. M. Leite Ferreira, R. N. Correia, and H. F. V. Fernandes. "In Vitro Bioactivity of PMMA-co-EHA Composites Filled with SiO2-Free Glass." Microscopy and Microanalysis 14, S3 (2008): 37–38. http://dx.doi.org/10.1017/s1431927608089319.

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Bioactive materials for potential medical application have inspired and stimulated new searches. It has been confirmed that bioactive glasses bond to living bone through an apatite layer that precipitates on their surface in physiological media. These glasses normally constituted by silica, where the silicon is the network former, induce apatite nucleation by the formation of Si-OH groups. The presence of OH groups seems to be of utmost importance in the bioactive behaviour of materials. It was revealed that even metals, such as pure titania gel can bond to bone, if previously subjected to alk
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Kamitakahara, Masanobu, Chikara Ohtsuki, Yuko Kozaka, Masao Tanihara, and Toshiki Miyazaki. "Apatite-Forming Ability of Glass-Ceramics Containing Whitlockite and Diopside in a Simulated Body Fluid." Key Engineering Materials 309-311 (May 2006): 341–44. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.341.

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Tricalcium phosphate (3CaO⋅P2O5, TCP) is known as a biodegradable material and already used clinically as important bone-repairing materials. However, the control of its bone-bonding ability, i.e. bioactivity, and biodegradability is not easy. On the other hand, diopside (CaO⋅MgO⋅2SiO2) ceramic shows a potential of direct contact with bone and high mechanical strength, but low biodegradability. We expected that a glass-ceramic containing TCP and diopside show high bioactivity and high mechanical strength, as well as biodegradability. Glasses with composition x(3CaO⋅P2O5)⋅(100-x) (CaO⋅MgO⋅2SiO2
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40

Hurrell-Gillingham, K., Ian M. Reaney, I. M. Brook, and P. V. Hatton. "Novel Fe2O3-Containing Glass Ionomer Cements: Glass Characterisation." Key Engineering Materials 284-286 (April 2005): 799–802. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.799.

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Glass-ionomer cements (GIC) have been used in dentistry for over 30 years. In the past ten years they have also been developed for use as medical grade bone cements. However, concerns have been raised over the biocompatibility of GIC’s in non-dental applications. The release of Al3+ ions from the cement has been related to localized poor bone mineralisation and neurotoxicity. There is a need therefore to develop Al2O3-free cements. One potential route is the substitution of Al2O3 with Fe2O3 in the glass. An Fe2O3-based glass for use in GIC‘s was fabricated. The glass was found to differ consid
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Trambitas, Cristian, Anca Maria Pop, Alina Dia Trambitas Miron, et al. "Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study." Revista de Chimie 70, no. 6 (2019): 1983–87. http://dx.doi.org/10.37358/rc.19.6.7259.

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Large bone defects are a medical concern as these are often unable to heal spontaneously, based on the host bone repair mechanisms. In their treatment, bone tissue engineering techniques represent a promising approach by providing a guide for osseous regeneration. As bioactive glasses proved to have osteoconductive and osteoinductive properties, the aim of our study was to evaluate by histologic examination, the differences in the healing of critical-sized calvarial bone defects filled with bioactive glass combined with adipose-derived mesenchymal stem cells, compared to negative controls. We
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Sales, Brian C. "Phosphate Glasses." MRS Bulletin 12, no. 5 (1987): 32–35. http://dx.doi.org/10.1557/s0883769400067488.

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Until recently, phosphate glasses were regarded as somewhat of a scientific curiosity—materials limited in technological application but nevertheless exhibiting interesting fundamental properties. Although the basic properties of many phosphate glasses have been studied on a laboratory scale during the past 50 years, very few of these materials proved to be of commercial interest. This lack of extensive practical application was primarily related to their poor chemical durability and a tendency to crystallize during processing.The pace of modern technological development continues to result in
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Faqhiri, Hamasa, Markus Hannula, Minna Kellomäki, Maria Teresa Calejo, and Jonathan Massera. "Effect of Melt-Derived Bioactive Glass Particles on the Properties of Chitosan Scaffolds." Journal of Functional Biomaterials 10, no. 3 (2019): 38. http://dx.doi.org/10.3390/jfb10030038.

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This study reports on the processing of three-dimensional (3D) chitosan/bioactive glass composite scaffolds. On the one hand, chitosan, as a natural polymer, has suitable properties for tissue engineering applications but lacks bioactivity. On the other hand, bioactive glasses are known to be bioactive and to promote a higher level of bone formation than any other biomaterial type. However, bioactive glasses are hard, brittle, and cannot be shaped easily. Therefore, in the past years, researchers have focused on the processing of new composites. Difficulties in reaching composite materials mad
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Pérez, Rebeca, Sandra Sanchez-Salcedo, Daniel Lozano, et al. "Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin." Nanomaterials 8, no. 8 (2018): 592. http://dx.doi.org/10.3390/nano8080592.

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Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their outstanding textural properties allow for high bioactivity when compared with other bioactive materials. Moreover, their great pore volumes allow these glasses to be loaded with a wide range of biomolecules to stimulate new bone formation. In this study, an MBG with a composition, in mol%, of 80% SiO2–15% CaO–5% P2O5 (Blank, BL) was compared with two analogous glasses containing 4% and 5% of ZnO (4ZN and 5ZN) before and after impregnation
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Wu, Chengtie, and Jiang Chang. "Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application." Interface Focus 2, no. 3 (2012): 292–306. http://dx.doi.org/10.1098/rsfs.2011.0121.

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The impact of bone diseases and trauma in the whole world has increased significantly in the past decades. Bioactive glasses are regarded as an important bone regeneration material owing to their generally excellent osteoconductivity and osteostimulativity. A new class of bioactive glass, referred to as mesoporous bioglass (MBG), was developed 7 years ago, which possess a highly ordered mesoporous channel structure and a highly specific surface area. The study of MBG for drug/growth factor delivery and bone tissue engineering has grown significantly in the past several years. In this article,
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Lee, Sung Ho, Akiko Obata, and Toshihiro Kasuga. "Structure of CaO-SrO-TiO2-P2O5 Glasses and their Ion-Releasing Abilities in Tris Buffer Solution." Advanced Materials Research 89-91 (January 2010): 342–46. http://dx.doi.org/10.4028/www.scientific.net/amr.89-91.342.

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SrO-containing calcium phosphate invert glasses, (60-x)CaO∙xSrO∙30P2O5∙7Na2O∙3TiO2 (mol%, x = 0 ~ 60), which are expected to inhibit bone resorption by osteoclast and enhance bone formation, were prepared and estimated in their ion release behavior in Tris buffer solution. The glasses gradually released ions and the dissolved amounts of ions were the smallest when the glass contained 20 mol% of SrO. Laser Raman spectra showed that the peaks of phosphate groups and TiOy polyhedral groups red-shifted with increasing the SrO content in the glasses. The red-shift is suggested to be due to decrease
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Kiani, A., N. J. Lakhkar, V. Salih, et al. "Titanium-containing bioactive phosphate glasses." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 370, no. 1963 (2012): 1352–75. http://dx.doi.org/10.1098/rsta.2011.0276.

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The use of biomaterials has revolutionized the biomedical field and has received substantial attention in the last two decades. Among the various types of biomaterials, phosphate glasses have generated great interest on account of their remarkable bioactivity and favourable physical properties for various biomedical applications relating to both hard and soft tissue regeneration. This review paper focuses mainly on the development of titanium-containing phosphate-based glasses and presents an overview of the structural and physical properties. The effect of titanium incorporation on the glassy
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48

Mohd Zain, Nurul Shazwani, Hasmaliza Mohamad, Tuti Katrina Abdullah, Siti Noorfazliah Mohd Noor, and Ahmad Kamil Fakhruddin Mokhtar. "The Performance of Lime Sludge Added Bioactive Glass in the Formation of HA Layer." Key Engineering Materials 694 (May 2016): 184–88. http://dx.doi.org/10.4028/www.scientific.net/kem.694.184.

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Lime sludge (LS) is a solid waste from lime making industry and normally disposed in landfill or recycled. LS has been studied as one of the raw materials in various ceramic productions such as bricks, ceramic tiles and glass-ceramics. In this study, LS was utilized in the preparation of bioactive glass using the 45S5 bioactive glass. The 45S5 bioactive glass contains SiO2 (45 wt.%), Na2O (24.5 wt.%), CaO (24.5 wt.%) and P2O5 (6 wt.%). It has the ability to bond with soft tissue and promote bone growth. The LS was combined with bioactive glass as a potential replacement of calcium carbonate (C
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Fiume, Elisa, Dilshat Tulyaganov, Graziano Ubertalli, Enrica Verné, and Francesco Baino. "Dolomite-Foamed Bioactive Silicate Scaffolds for Bone Tissue Repair." Materials 13, no. 3 (2020): 628. http://dx.doi.org/10.3390/ma13030628.

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The use of three-dimensional (3D) scaffolds is recognized worldwide as a valuable biomedical approach for promoting tissue regeneration in critical-size bone defects. Over the last 50 years, bioactive glasses have been intensively investigated in a wide range of different clinical applications, from orthopedics to soft tissue healing. Bioactive glasses exhibit the unique capability to chemically bond to the host tissue and, furthermore, their processing versatility makes them very appealing due to the availability of different manufacturing techniques for the production of porous and interconn
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Eldera, Samah S., Nourah Alsenany, Sarah Aldawsari, Gehan T. El-Bassyouni, and Esmat M. A. Hamzawy. "Characterization, biocompatibility and in vivo of nominal MnO2-containing wollastonite glass-ceramic." Nanotechnology Reviews 11, no. 1 (2022): 2800–2813. http://dx.doi.org/10.1515/ntrev-2022-0477.

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Abstract The present work pointed out the effect of adding different concentrations of MnO2 (0.25, 0.50, 1.00 and 2.00 wt%) on the structure and crystallization performance of wollastonite glass. Nominal MnO2-containing wollastonite glass was prepared with the addition of 10% Na2O to decrease the melting temperature through melt quenching technique. The thermal history of glasses indicated that the crystallization temperature was between 864 and 895°C. The heat treating of glasses at ∼900 and 1,100°C gave combeite (Na4Ca4Si6O18), rankinite (Ca3Si2O7), pseudowollastonite (Ca3Si3O9), bustamite (
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