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Journal articles on the topic 'Bos Embryology'

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Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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1

Supriyanto, Supriyanto, Sunardi Sunardi, and Imam Riadi. "Penerapan JST Backpropagation untuk Prediksi Siswa Penerima Bantuan." JURNAL MEDIA INFORMATIKA BUDIDARMA 6, no. 2 (April 25, 2022): 952. http://dx.doi.org/10.30865/mib.v6i2.3870.

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The role of education is to educate students and build quality human resources. School Operational Assistance (BOS) from the government is used to relieve students, not free schools but free students from school fees and extracurriculars. BOS can be used to provide scholarships to underprivileged students. Students are entitled to a scholarship if they meet three conditions, namely not having a Smart Indonesia Card (KIP), not having a Prosperous Family Card (KKS), and parental income of less than one million rupiah per month. The determination of BOS scholarship recipients is based on an agreement and joint decision by the management team, the teacher council, and the school committee. The process of determining students as scholarship recipients often encounters obstacles because it is done manually. This study applies backpropagation ANN to determine students who are eligible for BOS scholarships. The system is built based on the web using bootstrap as a framework, Javascript, and PHP. The training process uses a sample of 78 students with input architecture 4, hidden 6, output 1, learning rate 0.7, momentum 0.9, SSE 0.1, output 1, and a maximum of 10,000 iterations, an error of 0.03 is obtained. Testing with 21 student data obtained an error of 0.414923 and the accuracy of the test was 93.67%. The test results using the cause-effect graph technique can display the training process, graphs, error results, weight values and testing time with 93.67% success.

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2

Herrid, Muren, Soma Vignarajan, Rhonda Davey, Ina Dobrinski, and Jonathan R. Hill. "Successful transplantation of bovine testicular cells to heterologous recipients." Reproduction 132, no. 4 (October 2006): 617–24. http://dx.doi.org/10.1530/rep.1.01125.

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While heterologous germ cell transplantation was successful in pigs and goats, autologous transplantation alone has been reported to result in donor-derived spermatogenesis in cattle. The objective of this study was to investigate whether the transplantation of heterologous germ cells could result in colonization of recipient testes in cattle of different breeds. Testicular cells were isolated from 8 Bos taurus donor bull calves and then transferred into 15 Bos indicus-cross bull calves. All animals were prepubertal, donors were aged 5–7 months and recipients 5–11 months, and scrotal circumferences ranged from 15 to 22 cm. Single cell suspensions of donor testicular cells, prepared by enzymatic digestion, were labelled with fluorescent dyes PKH26 or CFDA-SE, before transfer into the rete testis of recipients under ultrasonographic guidance. To assess the longevity of colonization by donor cells, recipients were castrated 2–30 weeks after cell transfer. Donor cells were observed in 15/25 (60%) of the testes that received PKH26-labelled cells, whereas no CFDA-SE-positive cell was identified in any recipients. The maturity of the donors or recipients (measured by scrotal circumference) did not affect colonization potential. In freshly isolated tubules, clumps of PKH26-positive cells were observed, which indicated either cell division or extensive local colonization of specific areas of the tubules. In frozen sections, PKH26-positive cells were identified on the seminiferous tubule basement membrane, which indicated that these cells had successfully migrated from the tubule lumen and were likely to be spermatogonia. We conclude that PKH26 was more suitable for labelling donor testis cells and donor cells can be identified up to 6 months following transfer. These results indicate that allogeneic transplantation of testicular cells can occur between Bos taurus and Bos indicus cattle. Further studies will investigate functionality of transferred testicular cells.

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3

Totland, Geir K., and Harald Kryvi. "Distribution patterns of muscle fibre types in major muscles of the bull (Bos taurus)." Anatomy and Embryology 184, no. 5 (September 1991): 441–50. http://dx.doi.org/10.1007/bf01236050.

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4

McCool, C. J. "The cycle of the seminiferous epithelium in Bali cattle (Bos sondaicus)." Reproduction 87, no. 1 (September 1, 1989): 327–30. http://dx.doi.org/10.1530/jrf.0.0870327.

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5

Sillaste, Gerly, Lauris Kaplinski, Riho Meier, Ülle Jaakma, Elo Eriste, and Andres Salumets. "A novel hypothesis for histone-to-protamine transition in Bos taurus spermatozoa." Reproduction 153, no. 3 (March 2017): 241–51. http://dx.doi.org/10.1530/rep-16-0441.

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DNA compaction with protamines in sperm is essential for successful fertilization. However, a portion of sperm chromatin remains less tightly packed with histones, which genomic location and function remain unclear. We extracted and sequenced histone-associated DNA from sperm of nine ejaculates from three bulls. We found that the fraction of retained histones varied between samples, but the variance was similar between samples from the same and different individuals. The most conserved regions showed similar abundance across all samples, whereas in other regions, their presence correlated with the size of histone fraction. This may refer to gradual histone–protamine transition, where easily accessible genomic regions, followed by the less accessible regions are first substituted by protamines. Our results confirm those from previous studies that histones remain in repetitive genome elements, such as centromeres, and added new findings of histones in rRNA and SRP RNA gene clusters and indicated histone enrichment in some spermatogenesis-associated genes, but not in genes of early embryonic development. Our functional analysis revealed significant overrepresentation of cGMP-dependent protein kinase G (cGMP-PKG) pathway genes among histone-enriched genes. This pathway is known for its importance in pre-fertilization sperm events. In summary, a novel hypothesis for gradual histone-to-protamine transition in sperm maturation was proposed. We believe that histones may contribute structural information into early embryo by epigenetically modifying centromeric chromatin and other types of repetitive DNA. We also suggest that sperm histones are retained in genes needed for sperm development, maturation and fertilization, as these genes are transcriptionally active shortly prior to histone-to-protamine transition.

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6

Kay, G. W., J. A. N. Grobbelaar, and J. Hattingh. "Heritable testicular hypoplasia in Nguni (Bos indicus) bulls: vascular characteristics and testosterone production." Reproduction 96, no. 2 (November 1, 1992): 537–47. http://dx.doi.org/10.1530/jrf.0.0960537.

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7

Mukasa-Mugerwa, E., and Azage Tegegne. "Peripheral plasma progesterone concentration in zebu (Bos indicus) cows during pregnancy." Reproduction Nutrition Développement 29, no. 3 (1989): 303–6. http://dx.doi.org/10.1051/rnd:19890308.

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8

Rhodes, F. M., L. A. Fitzpatrick, K. W. Entwistle, and G. De'ath. "Sequential changes in ovarian follicular dynamics in Bos indicus heifers before and after nutritional anoestrus." Reproduction 104, no. 1 (May 1, 1995): 41–49. http://dx.doi.org/10.1530/jrf.0.1040041.

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9

Einspanier, R., W. WAmselgruber, F. Sinowatz, Th Henle, R. Ropke, and D. Scham. "Localization and concentration of a new bioactive acetic seminal fluid protein (aSFP) in bulls (Bos taurus)." Reproduction 98, no. 1 (May 1, 1993): 241–44. http://dx.doi.org/10.1530/jrf.0.0980241.

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10

Johnston, L. A., J. J. Parrish, R. Monson, L. Leibfried-Rutledge, J. L. Susko-Parrish, D. L. Northey, J. J. Rutledge, and L. G. Simmons. "Oocyte maturation, fertilization and embryo development in vitro and in vivo in the gaur (Bos gaurus)." Reproduction 100, no. 1 (January 1, 1994): 131–36. http://dx.doi.org/10.1530/jrf.0.1000131.

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11

Bauchart, D., and D. Durand. "Postprandial changes in the hepatic metabolism of lipoproteins in the preruminant calf, Bos spp." Reproduction Nutrition Development 34, no. 6 (1994): 621–22. http://dx.doi.org/10.1051/rnd:19940623.

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12

Hamilton, C. K., L. A. Favetta, G. P. Di Meo, S. Floriot, A. Perucatti, J. Peippo, J. Kantanen, A. Eggen, L. Iannuzzi, and W. A. King. "Copy Number Variation of Testis-Specific Protein, Y-Encoded (TSPY) in 14 Different Breeds of Cattle (Bos taurus)." Sexual Development 3, no. 4 (2009): 205–13. http://dx.doi.org/10.1159/000228721.

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13

Sousa, Noelita Melo, Benoit Remy, Bouchra El Amiri, José Ricardo De Figueiredo, Henri Banga-Mboko, Paulo Bayard Dias Gonçalves, and Jean-François Beckers. "Characterization of pregnancy-associated glycoproteins extracted from zebu (Bos indicus) placentas removed at different gestational periods." Reproduction Nutrition Development 42, no. 3 (May 2002): 227–41. http://dx.doi.org/10.1051/rnd:2002021.

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14

Mukasa-Mugerwa, E., Azage Tegegne, and Yihun Teklu. "Characterization of service intervals and frequency of short oestrus cycles in Zebu (Bos indicus) cows in Ethiopia." Reproduction Nutrition Développement 31, no. 4 (1991): 361–67. http://dx.doi.org/10.1051/rnd:19910402.

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15

Leplaix, L., D. Bauchart, D. Durand, PM Laplaud, and MJ Chapman. "Effects of dietary cholesterol on hepatic metabolism of triglyceride-rich lipoproteins in the preruminant calf, Bos spp." Reproduction Nutrition Development 32, no. 5-6 (1992): 490. http://dx.doi.org/10.1051/rnd:19920521.

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16

Lavery, K. "Identification and immunohistochemical localization of a haptoglobin-like protein in the tissues and fluids of the bovine (Bos taurus) ovary and oviduct." Reproduction 125, no. 6 (June 1, 2003): 837–46. http://dx.doi.org/10.1530/reprod/125.6.837.

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17

Cavalieri, J., J. E. Kinder, and L. A. Fitzpatrick. "Effect of acute treatment with progesterone on the timing and synchrony of ovulation in Bos indicus heifers treated with a norgestomet implant for 17 days." Reproduction 112, no. 2 (March 1, 1998): 249–58. http://dx.doi.org/10.1530/jrf.0.1120249.

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18

Fagundes, N. S., V. A. Michalczechen-Lacerda, E. S. Caixeta, G. M. Machado, F. C. Rodrigues, E. O. Melo, M. A. N. Dode, and M. M. Franco. "Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies." Molecular Human Reproduction 17, no. 2 (September 10, 2010): 85–91. http://dx.doi.org/10.1093/molehr/gaq075.

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19

Auboiron, S., D. Durand, JC Robert, MJ Chapman, and D. Bauchart. "Effects of dietary fat and L-methionine on the hepatic metabolism of very low density lipoproteins in the preruminant calf, Bos spp." Reproduction Nutrition Development 35, no. 2 (1995): 167–78. http://dx.doi.org/10.1051/rnd:19950205.

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20

Mukasa-Mugerwa, E., A. Tegegne, and R. Franceschini. "Influence of suckling and continuous cow-calf association on the resumption of post-partum ovarian function in Bos indicus cows monitored by plasma progesterone profiles." Reproduction Nutrition Développement 31, no. 3 (1991): 241–47. http://dx.doi.org/10.1051/rnd:19910305.

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21

Leplaix, L., Charlat, D. Durand, PM Laplaud, and D. Bauchart. "Effects of dietary cholesterol and saturated to polyunsaturated fatty-acid ratio on the hererogeneity of LDL and HDL particles in the 1.040-1.090 g/ml interval in the preruminant calf, Bos spp." Reproduction Nutrition Development 34, no. 6 (1994): 622–23. http://dx.doi.org/10.1051/rnd:19940625.

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22

Yamamoto, Takenori, Izu Andry Fijridiyanto, and Hiroshi Tobe. "Embryology ofHarrisonia(Cneoroideae, Rutaceae): a comparison with related genera and families." Botanical Journal of the Linnean Society 180, no. 3 (December 31, 2015): 386–400. http://dx.doi.org/10.1111/boj.12371.

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23

Oppelt, Birgit. "Der (früh-) kindliche Thorax: von Röntgen- bis zu CT-Untersuchungen." Radiopraxis 15, no. 04 (December 2022): 172–85. http://dx.doi.org/10.1055/a-1663-2630.

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Bereits das Früh- und Neugeborene bedarf einer Bildgebung zur Diagnostik von Erkrankungen. Das Thoraxröntgen, der Lungenultraschall, die CT, die MRT – all diese Verfahren benötigen für diese Patientengruppe eine hohe Expertise und eigene Untersuchungsprotokolle. Dieser Beitrag gibt einen Einblick in die Embryologie und einen Überblick über Diagnostikmöglichkeiten des Thorax beim Frühgeborenen, Säugling und Kind.

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24

Koscinski, Isabelle, Manuel Mark, Nadia Messaddeq, Jean Jacques Braun, Catherine Celebi, Jean Muller, Anna Zinetti-Bertschy, Nathalie Goetz, Hélène Dollfus, and Sylvie Rossignol. "Reproduction Function in Male Patients With Bardet Biedl Syndrome." Journal of Clinical Endocrinology & Metabolism 105, no. 12 (August 25, 2020): e4417-e4429. http://dx.doi.org/10.1210/clinem/dgaa551.

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Abstract Purpose Bardet-Biedl syndrome (BBS) is a ciliopathy with a wide spectrum of symptoms due to primary cilia dysfunction, including genitourinary developmental anomalies as well as impaired reproduction, particularly in males. Primary cilia are known to be required at the following steps of reproduction function: (i) genitourinary organogenesis, (ii) in fetal firing of hypothalamo-pituitary axe, (iii) sperm flagellum structure, and (iv) first zygotic mitosis conducted by proximal sperm centriole. BBS phenotype is not fully understood. Methods This study explored all steps of reproduction in 11 French male patients with identified BBS mutations. Results BBS patients frequently presented with genitourinary malformations, such as cryptorchidism (5/11), short scrotum (5/8), and micropenis (5/8), but unexpectedly, with normal testis size (7/8). Ultrasonography highlighted epididymal cysts or agenesis of one seminal vesicle in some cases. Sexual hormones levels were normal in all patients except one. Sperm numeration was normal in 8 out of the 10 obtained samples. Five to 45% of sperm presented a progressive motility. Electron microscopy analysis of spermatozoa did not reveal any homogeneous abnormality. Moreover, a psychological approach pointed to a decreased self-confidence linked to blindness and obesity explaining why so few BBS patients express a child wish. Conclusions Primary cilia dysfunction in BBS impacts the embryology of the male genital tract, especially epididymis, penis, and scrotum through an insufficient fetal androgen production. However, in adults, sperm structure does not seem to be impacted. These results should be confirmed in a greater BBS patient cohort, focusing on fertility.

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Quinlan, Robyn, Matthew Hind, and Phillip Beales. "16-P015 The role of BBS proteins in lung development." Mechanisms of Development 126 (August 2009): S266. http://dx.doi.org/10.1016/j.mod.2009.06.706.

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26

Sidrat, Tabinda, Abdul Aziz Khan, Myeong-Don Joo, Lianguang Xu, Marwa El-Sheikh, Jong-Hyuk Ko, and Il-Keun Kong. "Extracellular vesicles improve embryo cryotolerance by maintaining the tight junction integrity during blastocoel re-expansion." Reproduction 163, no. 4 (April 1, 2022): 219–32. http://dx.doi.org/10.1530/rep-21-0320.

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Cryopreservation is a process in which the intact living cells, tissues, or embryos are preserved at subzero temperatures for preservation. The cryopreservation process highly impacts the survival and quality of the in vitro-produced (IVP) embryos. Some studies have highlighted the use of oviduct extracellular vesicles (EVs) to improve the cryotolerance of IVP embryos but the mechanism has not been well studied. The present study unravels the role of in vitro cultured bovine oviduct epithelial cells-derived EVs in improving the re-expansion and hatching potential of thawed blastocysts (BLs). The comparison of cryotolerance between synthetic oviduct fluid (SOF) and SOF + EVs-supplemented day-7 cryopreserved BLs revealed that the embryo’s ability to re-expand critically depends on the intact paracellular sealing which facilitates increased fluid accumulation during cavity expansion after shrinkage. Our results demonstrated that BLs cultured in the SOF + EVs group had remarkably higher re-expansion (67.5 ± 4.2%) and hatching rate (84.8 ± 1.4%) compared to the SOF group (53.4 ± 3.4% and 63.9 ± 0.9%, respectively). Interestingly, EVs-supplemented BLs exhibited greater influence on the expression of core genes involved in trophectoderm (TE) maintenance, formation of tight junction (TJ) assembly, H2O channel proteins (aquaporins), and Na+/K+ ATPase alpha 1. The EVs improved the fluid flux and allowed the transport of H2O into an actively re-expanded cavity in EVs-cultured cryo-survived BLs relative to control BLs. Our findings explored the function of EVs in restoring the TE integrity, improved the cell junctional contacts and H2O movement which helps the blastocoel re-expansion after thawing the cryopreserved BLs.

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Payne, Molly R., Anne-Bine Skytte, and Joyce C. Harper. "The use of expanded carrier screening of gamete donors." Human Reproduction 36, no. 6 (April 11, 2021): 1702–10. http://dx.doi.org/10.1093/humrep/deab067.

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Abstract STUDY QUESTION What are the sperm and egg donor rejection rates after expanded carrier screening (ECS)? SUMMARY ANSWER Using an ECS panel looking at 46/47 genes, 17.6% of donors were rejected. WHAT IS KNOWN ALREADY The use of ECS is becoming commonplace in assisted reproductive technology, including testing of egg and sperm donors. Most national guidelines recommend rejection of donors if they are carriers of a genetic disease. If the use of ECS increases, there will be a decline in the number of donors available. STUDY DESIGN, SIZE, DURATION A review of the current preconception ECS panels available to donors was carried out through an online search. The genetic testing results of donors from Cryos International were analysed to determine how many were rejected on the basis of the ECS. PARTICIPANTS/MATERIALS, SETTING, METHODS Data on gamete donors and their carrier status was provided by Cryos International, who screen donors using their own bespoke ECS panel. The ECS panels identified through the review were compared to the Cryos International panel and data. MAIN RESULTS AND THE ROLE OF CHANCE A total of 16 companies and 42 associated ECS panels were reviewed. There were a total of 2673 unique disorders covered by the panels examined, with a mean of 329 disorders screened. None of these disorders were common to all panels. Cryos International screen 46 disorders in males and 47 in females. From 883 candidate donors, 17.6% (155/883) were rejected based on their ECS result. Carriers of alpha-thalassaemia represented the largest proportion of those rejected (19.4%, 30/155), then spinal muscular atrophy (15.5%, 24/155) and cystic fibrosis (14.8%, 23/155). LIMITATIONS, REASONS FOR CAUTION Panel information was found on company websites and may not have been accurate. WIDER IMPLICATIONS OF THE FINDINGS This study highlights the need for consistent EU regulations and guidelines that allow genetic matching of gamete donors to their recipients, preventing the need to reject donors who are known carriers. A larger ECS panel would be most beneficial; however, this would not be viable without matching of donors and recipients. STUDY FUNDING/COMPETING INTEREST(S) No specific funding was obtained. J.C.H. is the founder of Global Women Connected, a platform to discuss women’s health issues and the Embryology and PGD Academy, who deliver education in clinical embryology. She has been paid to give a lecture by Cryos in 2019. A-B.S. is an employee of Cryos International. TRIAL REGISTRATION NUMBER N/A

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28

Markert, Michael. "Modellierte Individualentwicklung. Humanembryologische Praktiken an der Universität Göttingen in der zweiten Hälfte des 20. Jahrhunderts." NTM Zeitschrift für Geschichte der Wissenschaften, Technik und Medizin 28, no. 4 (October 6, 2020): 481–517. http://dx.doi.org/10.1007/s00048-020-00275-3.

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Zusammenfassung Die Humanembryologische Dokumentationssammlung Blechschmidt, entstanden an der Universität Göttingen im Zeitraum von 1942 bis etwa 1970, stellt eine einmalige Kombination histologischer Schnittserien menschlicher Embryonen und darauf aufbauender, großformatiger und öffentlich zugänglicher Modelle dar. Nicht nur erfolgte diese Sammlungsgründung für die Disziplin der Humanembryologie erstaunlich spät, sondern ist auch in einer zweiten Hinsicht bemerkenswert: Während an anderen Standorten Modelle primär als Forschungsobjekte verstanden wurden und mit einem Lehreinsatz eine Umnutzung stattfand, war für den Göttinger Embryologen Erich Blechschmidt (1904–1992) von Beginn an ein pädagogischer Impetus maßgeblich. Im Beitrag werden die eigenwilligen Merkmale der Blechschmidt’schen Unternehmung vor ihrem disziplinären Hintergrund herausgearbeitet. Der Schwerpunkt liegt dabei auf den beiden für die Humanembryologie zentralen Praktiken des Sammelns und Modellierens und den dadurch in Göttingen geschaffenen Objektbeständen. Diese waren schon im Entstehungsprozess von einem besonderen Spannungsverhältnis von Individualität und Universalität geprägt, das sich auch in der späteren Nutzung der Sammlung spiegelt. Diese führt durch eine spezifische Individualisierung zuvor anonym gemachter Präparate weit aus der ursprünglichen fachwissenschaftlich-anatomischen Bestimmung in die breite gesellschaftliche Debatte um den ethischen Status menschlicher Embryonen und den Schwangerschaftsabbruch.

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29

Kieser, Patricia, and Miriam Schell. "Multisystem Inflammatory Syndrome in Children (MIS-C): ähnlich und doch ganz anders als das Kawasaki-Syndrom." Kinder- und Jugendmedizin 22, no. 04 (August 2022): 266–71. http://dx.doi.org/10.1055/a-1858-9890.

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ZUSAMMENFASSUNGIm Zeitraum vom 10. November 2020 bis zum 26. Dezember 2021 wurden im Katholischen Kinderkrankenhaus Wilhelmstift in Hamburg sechs Kinder mit MIS-C behandelt. Mögliche Differenzialdiagnosen wie das Kawasaki-Syndrom (KS), Toxisches Schocksyndrom sowie die Hämophagozytische Lymphohistiozytose konnten unter anderem durch den Nachweis einer positiven SARS-CoV-2-Serologie ausgeschlossen werden. Anders als beim KS sind Kinder mit MIS-C älter und fallen durch eine führende kardiale und abdominelle Symptomatik auf. Eine mit ventrikulärer Dysfunktion einhergehende Kreislaufinstabilität macht in der Regel eine intensivmedizinische Behandlung notwendig. Trotz des schweren Krankheitsverlaufs ist die MIS-C-Erkrankung unter adäquater Therapie (intravenöse Immunglobuline, Methylprednisolon, Azetylsalizylsäure sowie hämodynamischer Support) mit einer guten Prognose verbunden.

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Meikle, A., M. Kulcsar, Y. Chilliard, H. Febel, C. Delavaud, D. Cavestany, and P. Chilibroste. "Effects of parity and body condition at parturition on endocrine and reproductive parameters of the cow." Reproduction 127, no. 6 (June 2004): 727–37. http://dx.doi.org/10.1530/rep.1.00080.

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The effect of parity (multiparous vs primiparous) and body condition score (BCS; <3.0 or ≥3.0, lean vs fat) at parturition on metabolic and endocrine profiles from 1 month before to 2 months after parturition were studied in 42 Holstein cows grazing on improved pastures. BCS and milk production were determined every 2 weeks. Non-esterified fatty acids (NEFA), β-hydroxy-butyrate (BHB), insulin, IGF-I, leptin, thyroxine (T4) and 3,3′,5-tri-iodothyroinine (T3) were determined in plasma every 10 days. Progesterone was determined three times per week after parturition. Primiparous cows had a lower BCS during the early postpartum period and produced less milk than multiparous animals. Primiparous cows had higher NEFA concentrations and they presented more samples with BHB concentrations of >1 mmol/l than multiparous cows. Multiparous cows had higher T3, T4 and IGF-I concentrations, while fat cows had higher leptin and IGF-I concentrations. All hormone concentrations were diminished in the first week postpartum. Primiparous cows and fat cows presented a steeper decay of IGF-I and leptin around parturition than multiparous cows and lean cows. While thyroid hormones and IGF-I showed increasing concentrations from approximately day 30, leptin concentrations remained low until the end of the experimental period. The initiation of ovarian cyclicity was delayed in primiparous cows and especially in primiparous lean cows, consistent with longer intervals from parturition to first service and to conception. The endocrine signals most likely to inform the reproductive axis regarding a negative energy balance were IGF-I and leptin.

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Okishima, Takahiro, Kazushi Takamura, Yuji Matsuoka, Shozo Ohdo, and Kunio Hayakawa. "Cardiovascular anomalies in chick embryos produced by bis-diamine in dimethylsulfoxide." Teratology 45, no. 2 (February 1992): 155–62. http://dx.doi.org/10.1002/tera.1420450209.

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32

Hanato, Takashi, Masao Nakagawa, Nobuhiko Okamoto, Setsuko Nishijima, Hidetoshi Fujino, Morimi Shimada, Yoshihiro Takeuchi, and Kyoko Imanaka-Yoshida. "Developmental defects of coronary vasculature in rat embryos administered bis-diamine." Birth Defects Research Part B: Developmental and Reproductive Toxicology 92, no. 1 (December 6, 2010): 10–16. http://dx.doi.org/10.1002/bdrb.20279.

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33

Desroches, Mireille, Liza Lee, Shamir Mukhi, and Christina Bancej. "Représentativité du programme participatif de surveillance des maladies ActionGrippe, 2015–2016 à 2018–2019 : comment les participants se comparent-ils à la population canadienne?" Relevé des maladies transmissibles au Canada 47, no. 09 (September 10, 2021): 401–9. http://dx.doi.org/10.14745/ccdr.v47i09a03f.

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Contexte : Le programme ÉpiGrippe est le système de surveillance national du Canada chargé de suivre la propagation de la grippe. Son volet de surveillance syndromique surveille la propagation du syndrome d’allure grippale en temps quasi réel pour détecter les signaux d’une activité inhabituelle ou accrue. Les données de surveillance syndromique sont recueillies à partir de deux sources principales : le Programme de surveillance des praticiens sentinelles et le programme ActionGrippe. Nous avons évalué la représentativité de la population participante la plus récente afin de comprendre les variations du taux de représentation depuis 2015, de cerner les écarts démographiques et géographiques ainsi que les corrélats ou déterminants de la participation pour caractériser un participant type. Méthodes : Dans cette étude transversale en série, les caractéristiques des participants au cours de quatre saisons grippales consécutives (2015–2016, 2016–2017, 2017–2018 et 2018–2019) ont été comparées à celles du Recensement canadien de 2016 et des enquêtes nationales sur la couverture vaccinale contre la grippe saisonnière de 2015–2016, de 2016–2017, de 2017–2018 et de 2018–2019. Les associations entre les facteurs démographiques et le niveau de participation des utilisateurs ont également été analysées parmi la population participant au programme ActionGrippe en 2018–2019. Résultats : Les enfants en bas âge (0 à 4 ans) et les personnes âgées (65 ans et plus) étaient sous-représentés dans le programme ActionGrippe au cours des quatre saisons grippales. Les femmes et les participants urbains étaient largement surreprésentés. La couverture vaccinale est restée considérablement plus élevée parmi les populations participant au programme ActionGrippe au cours des quatre dernières saisons grippales dans tous les groupes d’âge. Le niveau de participation au programme ActionGrippe était associé à l’âge et au statut d’immunisation, mais pas au sexe ni à la géographie. Au cours des quatre années de mise en œuvre, la population participant au programme ActionGrippe est devenue plus représentative de la population canadienne en ce qui concerne l’âge et la géographie (urbaine/rurale et provinciale/territoriale). Conclusion : Les participants au programme ActionGrippe sous-représentent les enfants en bas âge et les personnes âgées du Canada et surreprésentent ceux et celles qui adoptent des comportements favorables à la santé, comme l’indique la couverture vaccinale élevée contre la grippe, ce qui correspond aux biais de réponse typiques des enquêtes volontaires. La représentativité serait probablement améliorée par un recrutement ciblé des groupes sous-représentés, tels que les hommes, les personnes âgées et les Canadiens vivant dans les régions rurales.

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Wibowo, Danang Novianto, and Anita Sukmawati. "Peningkatan Laju Pelarutan Celecoxib Menggunakan Dispersi Padat dengan Polimer HPMC yang Dikombinasi PVP dan PEG 6000." JURNAL ILMU KEFARMASIAN INDONESIA 20, no. 1 (April 29, 2022): 81. http://dx.doi.org/10.35814/jifi.v20i1.887.

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Celecoxib adalah obat yang memiliki kelarutan yang rendah dan dikategorikan dalam Biopharmaceutical Classification System (BCS) kelas II sehingga perlu dibuat dalam dispersi padat sebagai upaya untuk memperbaiki kelarutan obat. Penelitian ini bertujuan untuk meningkatkan laju pelarutan celecoxib pada sistem dispersi padat celecoxib dengan polimer Hidroksipropil metilselulosa (HPMC) yang dikombinasikan dengan polivinil pirolidon (PVP) dan polietilenglikol (PEG) 6000. Dispersi padat celecoxib (DPC) dibuat dengan matriks HPMC-PVP dengan rasio 1:2 dan 2:1 serta HPMC-PEG 6000 dengan rasio 1:2 dan 2:1. Uji laju pelarutan DPC dievaluasi menggunakan metode disolusi dan uji karakteristik fisik DPC dievaluasi menggunakan metode X-ray Powder Diffraction (XRPD). Nilai laju pelarutan tertinggi ditunjukkan pada DPC dengan pembawa HPMC-PVP 1:2 sebesar 0,808 mg/cm2/menit. Nilai tersebut lebih tinggi jika dibandingkan dengan celecoxib murni (0,400 mg/cm2/menit). Hasil evaluasi derajat kristalin serbuk dispersi padat celecoxib dengan berbagai perbandingan pembawa menggunakan metode X-ray Diffraction menunjukkan terjadinya penurunan intensitas puncak interferansi fase kristalin. Sistem dispersi padat celecoxib dapat meningkatkan laju pelarutan celecoxib sebesar dua kali dibanding celecoxib murni. Nilai laju pelarutan tertinggi ditunjukkan pada dispersi padat celecoxib dengan rasio 1:2 HPMC-PVP sebagai matrix.

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Nakagawa, Masao, Setsuko Nishijima, Hidetoshi Fujino, Takashi Hanato, and Nobuhiko Okamoto. "Teratogenic effect of bis-diamine on embryonic rat heart." Congenital Anomalies 40, no. 3 (September 2000): 157–61. http://dx.doi.org/10.1111/j.1741-4520.2000.tb00881.x.

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Okamoto, Nobuhiko, Masao Nakagawa, Hidetoshi Fujino, Setsuko Nishijima, Takashi Hanato, Tsutomu Narita, Yoshihiro Takeuchi, and Kyoko Imanaka-Yoshida. "Teratogenic effects of bis-diamine on the developing myocardium." Birth Defects Research Part A: Clinical and Molecular Teratology 70, no. 3 (2004): 132–41. http://dx.doi.org/10.1002/bdra.20001.

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Mulatsari, Esti, Esti Mumpuni, Agus Purwanggana, and Siti Marsha Dyah Kusumaningtyas. "Formulasi Gel Antijerawat Dengan 1,5-Bis(3’-Etoksi-4’-Hidroksifenil)-1,4-Pentadien-3-On (EHP) Sebagai Bahan Antibakteri." JURNAL ILMU KEFARMASIAN INDONESIA 19, no. 2 (December 3, 2021): 216. http://dx.doi.org/10.35814/jifi.v19i2.1085.

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Jerawat merupakan penyakit kulit yang menyebabkan papula folikuler non-inflamasi, nodul, pustule dan radang papula. Di pasaran terdapat berbagai sediaan antijerawat oral maupun topikal. Gel merupakan sediaan topikal yang mempunyai daya absorpsi yang lebih baik daripada krim. Gel anti jerawat diformulasi dengan senyawa aktif antibakteri. Senyawa 1,5-bis(3’-etoksi-4’-hidroksifenil) 1,4-pentadien-3-on (EHP) adalah salah satu senyawa analog kurkumin yang telah berhasil disintesis oleh Mumpuni dkk, 2010. EHP berpotensi menghambat pertumbuhan mikroba patogen seperti Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli dan Salmonella tyhpi, serta memiliki aktivitas antiinflamasi. Penelitian ini bertujuan membuat formula gel antijerawat dengan bahan aktif EHP sebagai agent antimikroba. Formula diuji stabilitas fisika dan kimia meliputi organoleptik, daya sebar, homogenitas, viskositas, sifat alir, aktivitas mikrobiologi serta kemampuan iritasi kulit. EHP diformulasikan dalam sediaan gel dalam berbagai konsentrasi.Uji stabilitas sediaan gel dilakukan pada suhu 40 °C; RH ± 75% selama 4 minggu. Hasil penelitian menunjukkan EHP dapat diformulasikan menjadi sediaan gel yang memenuhi persyaratan mutu fisika dan kimia. Sediaan gel dengan bahan aktif EHP 0.1%; tretionin 0,01%; carbopol 940 1,0%; trietanolamin 1,0%; propilenglikol 15%; etanol (96%) 10%; dapat menghambat bakteri Propionibacterium acnes dengan nilai diameter daerah hambat sebesar 19,6 mm, uji iritasi terhadap kulit kelinci tidak menimbulkan iritasi, dengan demikian sediaan gel dengan bahan aktif EHP layak dikembangkan sebagai produk gel antijerawat.

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Dinata, Rozzi Kesuma, Bustami Bustami, Ar Razi, and Muhammad Arasyi. "Algoritma Dijkstra dan Bellman-Ford dalam Sistem Pemetaan Barbershop di Kota Lhokseumawe." INFORMAL: Informatics Journal 7, no. 2 (August 31, 2022): 128. http://dx.doi.org/10.19184/isj.v7i2.33303.

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A Barbershop service provider is a company that provides hair care to the community. Many people are currently doing business in this field, and many business actors are opening Barbershops in a variety of locations, ranging from campuses to office districts to densely populated towns. In Lhokseumawe City, there are 12 Barbershops. The application's benefit is that it can identify the shortest path from the user's location to the selected Barbershop, as well as the Barbershop's location and a brief description of the Barbershops in Lhokseumawe City. Only the system's defined nodes can be used to find the fastest route to the Barbershop. Dijkstra's method was chosen because it works against all current alternative functions and provides the shortest path from all nodes, ensuring that the shortest path is produced optimally. Because the Bellman-Ford algorithm is a variant of the BFS (best-first-search) algorithm, which is also employed in the search for the closest distance when the search for the closest distance has a negative weight, it was chosen. The same results were obtained in picking the route based on the results of the route selection test. However, when the two techniques are compared in terms of program execution time, Dijkstra's algorithm is faster than the Bellman-Ford algorithm.

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Groß, Nele, Louise Marshall, Martina Jürgensen, Fabian Frielitz, Wiebke Birnbaum, Anna Bacia, and Olaf Hiort. "Versorgung von Menschen mit Besonderheiten der Geschlechtsentwicklung." Kinder- und Jugendmedizin 22, no. 02 (April 2022): 92–99. http://dx.doi.org/10.1055/a-1760-0749.

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ZUSAMMENFASSUNG Hintergrund Die gesundheitsbezogene Lebensqualität von Menschen mit Besonderheiten der Geschlechtsentwicklung wird in der Literatur unterschiedlich dargestellt. Im Jahr 2006 wurden Rahmenpunkte der Versorgung festgelegt; zentral sind die Einbindung der Patient*innen in Entscheidungsprozesse, psychologische Begleitung sowie die multidisziplinäre Versorgung in Zentren. In Lübeck wurde ein Versorgungskonzept aufgebaut, das innerhalb dieses Rahmens eine hohe gesundheitsbezogene Lebensqualität von Patient*innen ermöglichen soll. Dieses Konzept wird im vorliegenden Beitrag evaluiert. Methodik Von 2017 bis 2020 wurden 68 Patient*innen und Elternteile mittels eines standardisierten Fragebogens befragt (CHC-SUN, Child Health Care – Satisfaction, Utilization and Needs, in einer an die Sprechstunde adaptierten Form). Zusätzlich wurden mit sieben Studienteilnehmer*innen Telefoninterviews geführt. Ergebnisse Die Befragten gaben überwiegend an, großes Vertrauen in das interdisziplinäre Team aufgebaut zu haben. Durch die Erklärungen des Teams konnten sie die geschlechtliche Besonderheit verstehen und medizinische Entscheidungen sicher treffen. Die Anwesenheit einer Psychologin war entscheidend, um Ängste und Zukunftssorgen zu besprechen. Die Befragten fanden überwiegend zu einem positiven Umgang mit der Diagnose. Diskussion Das Versorgungskonzept kann als Modell dienen, um eine hohe Behandlungszufriedenheit zu erreichen. Die Diagnose anzunehmen, stellt für Patient*innen und Familien einen herausfordernden Prozess dar, den das Sprechstundenteam unterstützend begleiten kann. Die Studie war jedoch durch ein kleines Kollektiv limitiert.

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Adamiak, S. J., K. Powell, J. A. Rooke, R. Webb, and K. D. Sinclair. "Body composition, dietary carbohydrates and fatty acids determine post-fertilisation development of bovine oocytes in vitro." Reproduction 131, no. 2 (February 2006): 247–58. http://dx.doi.org/10.1530/rep.1.00871.

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This study assessed the interactive effects of carbohydrate type (fibre vs starch) and fatty acid (FA) supplementation (0% vs 6% calcium soaps of palm oil FA) on the post-fertilisation development of oocytes recovered from low and moderate body condition score (BCS) heifers. A secondary objective was to compare the FA composition of plasma to that of granulosa cells (GCs) and cumulus–oocyte complexes (COCs) from these animals, and to relate these findings to the developmental potential of oocytes. Plasma, GCs and COCs were recovered from 32 heifers on day 5 of a synchronised oestrous cycle for FA analyses. Oocytes were also recovered on days 10 and 15 of the same cycle after short-term ovarian stimulation (FSH + GnRH), and matured, fertilised and cultured to the blastocyst stagein vitro. High levels of dietary starch increased (P< 0.01) plasma insulin but, together with dietary FA, reduced (P< 0.05) blastocyst yields in low, but not in moderate, BCS heifers. Diet-induced alterations to the FA content of plasma were less apparent in GCs and COCs. In summary, although dietary lipids increased the FA content of COCs, the selective uptake of saturated FAs at the expense of mainly polyunsaturated FAs within the follicular compartment ensured that the FA composition of COCs was largely unaffected by diet. However, the concentration of saturated FAs within COCs was inherently high, and so further increases in FA content may have impaired post-fertilisation development. The data establish a robust nutritional framework for more detailed studies into the mechanistic effects of dietary composition on the post-fertilisation developmental potential of oocytes.

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Nishijima, Setsuko, Masao Nakagawa, Hidetoshi Fujino, Takashi Hanato, Nobuhiko Okamoto, and Morimi Shimada. "Teratogenic effects of bis-diamine on early embryonic rat heart: An in vitro study." Teratology 62, no. 2 (2000): 115–22. http://dx.doi.org/10.1002/1096-9926(200008)62:2<115::aid-tera8>3.0.co;2-#.

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Tiboni, Gian Mario, Elisabetta Iammarrone, Franca Giampietro, Debora Lamonaca, Umberto Bellati, and Carmine Di Ilio. "Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin." Teratology 59, no. 2 (February 1999): 81–87. http://dx.doi.org/10.1002/(sici)1096-9926(199902)59:2<81::aid-tera2>3.0.co;2-h.

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43

Zweck, Lois. ""Führ uns an der Hand bis ins Vaterland!" Die Auswanderung preußischer Altlutheraner nach Südaustralien Mitte des 19. Jahrhunderts by Johannes Boxdörfer." Lutheran Quarterly 36, no. 2 (June 2022): 234–36. http://dx.doi.org/10.1353/lut.2022.0057.

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Nwosu, Andrea, Liza Lee, Kara Schmidt, Steven Buckrell, Claire Sevenhuysen, and Christina Bancej. "Rapport annuel national sur la grippe dans le contexte mondial, Canada, 2020–2021." Relevé des maladies transmissibles au Canada 47, no. 10 (October 14, 2021): 450–58. http://dx.doi.org/10.14745/ccdr.v47i10a02f.

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Au cours de la saison de la grippe du Canada en 2020–2021, il n’y a pas eu de circulation communautaire de la grippe. Seulement 69 cas positifs détectés de la grippe ont été signalés, et le pourcentage de réponses positives n’a pas dépassé 0,1 %. Les indicateurs de la grippe ont atteint des creux historiques par rapport aux six saisons précédentes, et aucune éclosion de grippe confirmée en laboratoire ni aucun résultat grave n’ont été signalés par les provinces et les territoires. À l’échelle mondiale, la circulation de la grippe était à des niveaux historiquement bas dans les hémisphères du Nord et du Sud. La diminution de l’activité grippale observée au Canada et à l’échelle mondiale coïncide avec la mise en œuvre de mesures de santé publique non pharmaceutiques visant à atténuer la propagation de la maladie à coronavirus 2019 (COVID-19). Bien qu’il soit difficile de prédire quand la grippe commencera à se propager de nouveau, compte tenu de l’augmentation de la vaccination contre la COVID-19 et de l’assouplissement des mesures de santé publique, on peut s’attendre à une résurgence de la grippe qui pourrait être plus grave ou plus intense que les saisons récentes. La vaccination contre la grippe, ainsi que les mesures de santé publique non pharmaceutiques, demeure la meilleure méthode pour prévenir la propagation et l’impact de la grippe. Les autorités de la santé publique doivent demeurer vigilantes, maintenir la surveillance et continuer de planifier la circulation accrue de la grippe saisonnière.

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Kise, Kazuyoshi, Masao Nakagawa, Nobuhiko Okamoto, Takashi Hanato, Noriko Watanabe, Setsuko Nishijima, Hidetoshi Fujino, Yoshihiro Takeuchi, and Isao Shiraishi. "Teratogenic effects of bis-diamine on the developing cardiac conduction system." Birth Defects Research Part A: Clinical and Molecular Teratology 73, no. 8 (2005): 547–54. http://dx.doi.org/10.1002/bdra.20163.

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IGAWA, Hiroharu H., Harukazu NAKAMURA, and Mineo YASUDA. "Bis(dicholroacetyl)diamine-induced Craniofacial Anomalies in Jcl: ICR and A/J Mice." Congenital Anomalies 25, no. 1 (March 1985): 45–56. http://dx.doi.org/10.1111/j.1741-4520.1985.tb00633.x.

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SUMIDA, Hiroshi, Harukazu NAKAMURA, Tatsuhiro MATSUO, and Mineo YASUDA. "Effects of Bis-diamine to Cardiac Mesenchymal Cell Migration of the Chick Embryo." Congenital Anomalies 35, no. 2 (June 1995): 215–22. http://dx.doi.org/10.1111/j.1741-4520.1995.tb00613.x.

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De-Kun, Li, Zhou Qi-Dong, Qin Xing-Bo, Sun Rong-Min, Zhu Xi-Lan, Cheng He-Jian, Wang Cheng-Su, et al. "An epidemiological study on the effect of N, N′-methylene-bis-(2-amino-1,3,4-thiadiazole) (MATDA) on outcomes of pregnancy." Teratology 33, no. 3 (June 1986): 289–97. http://dx.doi.org/10.1002/tera.1420330306.

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FUJINO, Hidetoshi, Masao NAKAGAWA, and Morimi SHIMADA. "Immunohistochemical Distribution of HNK-1 and N-CAM in Rat Embryos Treated with Bis-Diamine." Congenital Anomalies 39, no. 4 (December 1999): 281–93. http://dx.doi.org/10.1111/j.1741-4520.1999.tb00567.x.

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Fujino, Hidetoshi, Masao Nakagawa, Setsuko Nishijima, Nobuhiko Okamoto, Takashi Hanato, Noriko Watanabe, Takeaki Shirai, Hiroshi Kamiya, and Yoshihiro Takeuchi. "Morphological differences in cardiovascular anomalies induced by bis-diamine between Sprague-Dawley and Wistar rats." Congenital Anomalies 45, no. 2 (June 2005): 52–58. http://dx.doi.org/10.1111/j.1741-4520.2005.00063.x.

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