Academic literature on the topic 'Boron-neutron capture therapy'
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Journal articles on the topic "Boron-neutron capture therapy":
Taskaev, S. Yu. "Boron Neutron Capture Therapy." Physics of Atomic Nuclei 84, no. 2 (March 2021): 207–11. http://dx.doi.org/10.1134/s106377882101021x.
ONO, Koji, Minoru SUZUKI, Shinichiro MASUNAGA, Natsuko KONDO, Yoshinori SAKURAI, Hiroki TANAKA, Yuko KINASHI, and Akira MARUHASHI. "Boron Neutron Capture Therapy." RADIOISOTOPES 61, no. 4 (2012): 209–22. http://dx.doi.org/10.3769/radioisotopes.61.209.
FREEMANTLE, MICHAEL. "BORON NEUTRON CAPTURE THERAPY." Chemical & Engineering News 80, no. 34 (August 26, 2002): 13. http://dx.doi.org/10.1021/cen-v080n034.p013.
Beddoe, A. H. "Boron neutron capture therapy." British Journal of Radiology 70, no. 835 (July 1997): 665–67. http://dx.doi.org/10.1259/bjr.70.835.9245876.
Slatkin, Daniel N. "Boron neutron-capture therapy." Neutron News 1, no. 4 (January 1990): 25–28. http://dx.doi.org/10.1080/10448639008229357.
Ota, Ichiro, and Tadashi Kitahara. "Boron Neutron Capture Therapy (BNCT)." Practica Oto-Rhino-Laryngologica 107, no. 12 (2014): 937–46. http://dx.doi.org/10.5631/jibirin.107.937.
&NA;. "Improving boron neutron capture therapy." Inpharma Weekly &NA;, no. 971 (January 1995): 8. http://dx.doi.org/10.2165/00128413-199509710-00016.
Mumot, M. "325. Boron Neutron Capture Therapy." Reports of Practical Oncology & Radiotherapy 8 (2003): S354—S355. http://dx.doi.org/10.1016/s1507-1367(03)70808-6.
Kato, I. "S17.1 Boron neutron capture therapy." Oral Oncology Supplement 1, no. 1 (January 2005): 63. http://dx.doi.org/10.1016/s1744-7895(05)80118-x.
Sauerwein, Wolfgang A. G., Lucie Sancey, Evamarie Hey-Hawkins, Martin Kellert, Luigi Panza, Daniela Imperio, Marcin Balcerzyk, et al. "Theranostics in Boron Neutron Capture Therapy." Life 11, no. 4 (April 10, 2021): 330. http://dx.doi.org/10.3390/life11040330.
Dissertations / Theses on the topic "Boron-neutron capture therapy":
Howard, William Bruce. "Accelerator-based boron neutron capture therapy." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/44479.
Hefne, Jameel. "Neutron spectrum measurement for Boron Neutron Capture Therapy." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16625.
Goorley, John Timothy 1974. "Boron neutron capture therapy treatment planning improvements." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/49670.
Includes bibliographical references.
The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations were the most time consuming aspect of the treatment planning process, requiring more than thirty six hours for scoping calculations of three to five beams and final calculations for two beams, it was targeted for improvement. Three approaches were used to reduce the calculation times. A statistical uncertainty analysis was performed on doses rates and showed that a fewer number of particles could not be used and still meet uncertainty requirements in the region of interest. Unused features were removed and assumptions specific to the Harvard/MIT BNCT treatment planning calculations were hard wired into MCNP by Los Alamos personnel, resulting in a thirty percent decrease in runtimes. MCNP was also installed in parallel on the treatment planning computers, allowing a factor of improvement by roughly the number of computers linked together in parallel. After theses enhancements were made, the final executable, MCNPBNCT, was tested by comparing its calculated dose rates against the previously used executable, MCNPNEHD. Since the dose rates in close agreement, MCNPBNCT was adopted. The final runtime improvement to a single beam scoping run by linking the two 200MHz Pentium Pro computers was to reduce the wall clock runtime from 2 hours thirty minutes to fifty nine minutes. It is anticipated that the addition of ten 900 MHz CPUs will further reduce this calculation to three minutes, giving the medical physicist or radiation oncologist the freedom to use an iterative approach to try different radiation beam orientations to optimize treatment. Additional aspects of the treatment planning process were improved. The previously unrecognized phenomenon of peak dose movement during irradiation and its potential for overdosing the subject was identified. A method of predicting its occurrence was developed to prevent this from occurring. The calculated dose rate was also used to create dose volume histograms and volume averaged doses. These data suggest an alternative method for categorizing the subjects, rather than by peak tissue dose.
by John Timothy Goorley.
S.M.
Matalka, Khalid Zuhair. "Boron neutron capture therapy of brain tumors /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu148778039326795.
Guidi, Claretta. "Sviluppo e applicazioni della boron neutron capture therapy." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13399/.
Shah, Jungal (Jugal Kaushik). "Hypoxia-selective compounds for boron neutron capture therapy." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44829.
"June 2008."
Includes bibliographical references.
Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal cells. A general problem with the tumor seeking compounds is that drug delivery is dependent upon sufficient vascularization within the tumor. To investigate the possibility of delivering boron to hypoxic regions of tumor, a new boronated nitroimidazole delivery agent has been synthesized as a carrier of boron-10 for BNCT. It is expected that this will be used in combination with the existing boron carrier boronophenylalanine-fructose to treat solid tumors. An immunohistochemical protocol to visualize hypoxia was tested and refined to confirm the suitability of two tumor models established in the lab for hypoxia related uptake studies. The immunohistochemical protocol is used to detect pimonidazole, which localizes at hypoxic regions in tissue and is the parent compound for the new hypoxia-selective boron carrier. The protocol was used to test and confirm the suitability of a hypoxic in vivo tumor model. Two tumor lines were tested: SCCVII squamous cell carcinoma and EMT-6 murine mammary carcinoma. Both exhibited hypoxia. Finally, quantitative studies using Inductive Coupled Plasma Atomic Emission Spectrum demonstrated that the synthesized boronated nitroimidazole reaches suitable concentrations in SCCVII and F98 tumor. Future therapeutic studies are required to empirically confirm the effectiveness of this compound.
by Jugal Shah.
S.B.
Wang, Zhonglu. "Design of a Boron Neutron Capture Enhanced Fast Neutron Therapy Assembly." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14100.
Sweezy, Jeremy Ed. "Development of a boron neutron capture enhanced fast neutron therapy beam." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/17107.
Kudchadker, Rajat. "Optimized accelerator based epithermal neutron beams for boron neutron capture therapy /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821332.
Chung, Yoonsun. "Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44784.
Includes bibliographical references (p. 123-132).
This thesis evaluates the radiobiological effectiveness of three new boron compounds namely a boronated porphyrin (BOPP) and two liposome formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro and in vivo comparisons that characterize compounds relative to boric acid and boronophenylalanine (BPA). In vitro evaluations utilized a colorimetric assay and 96-well plates to minimize the quantities of compound required for testing. The assay was optimized for the murine SCCVII, squamous cell carcinoma to determine the chemical toxicity and relative cellular uptake of a compound. BOPP was toxic at low concentrations and comparisons between the different compounds for thermal neutron irradiations were performed with approximately 5 [mu]g 10B/ml in the culture medium to allow radiation induced effects to govern the observed response. Using less than 300 [mu]g of compound and 250 kVp X-rays as control irradiations, a compound biological effectiveness (CBE) of 3.3 ± 0.7 was determined for BOPP that is comparable to the result for boric acid (3.5 ± 0.5) indicating a non-selective intracellular accumulation of 10B. BPA has a significantly higher CBE of 6.1 + 0.7. Boronated liposomes (MAC-16 and MAC+TAC) were evaluated with the EMT-6 murine mammary carcinoma. Biodistribution studies showed high 10B uptake in tumor (20-40 [mu]g 10B/g) 30 hours after a single i.v. injection (dose 6-20 [mu]g 10B per gram of body weight). Tumor control experiments were performed using thermal neutrons to study the efficacy of the boron delivered by liposomes and BPA. The MAC-16 produced a 16 % tumor control and BPA (dose 43 [mu]g 10B/gbw) 63 % for tumor boron concentrations of approximately 20 [mu]g 10B/g and the same neutron fluence.
(cont.) Liposome doses were limited by injection volume and so two injections were tried 2-hours apart that doubled the boron concentration in tumor compared to a single administration. This improved the therapeutic response to 67 % with less apparent skin damage than with BPA. Microscopic studies using fluorescent labeled liposomes revealed 10B was nonuniformly distributed and concentrated at the edge of the tumor. Based on these studies in the tumor cell lines chosen neither of the compounds appear superior to BPA.
by Yoonsun Chung.
Ph.D.
Books on the topic "Boron-neutron capture therapy":
Gabel, Detlef, and Ray Moss, eds. Boron Neutron Capture Therapy. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2.
1932-, Hatanaka Hiroshi, ed. Boron-neutron capture therapy for tumors. Niigata, Japan: Nishimura, 1986.
1929-, Mishima Yutaka, and International Symposium on Neutron Capture Therapy (6th : 1994 : Kōbe-shi, Japan), eds. Cancer neutron capture therapy. New York: Plenum Press, 1996.
Nievaart, Victor Alexander. Spectral tailoring for boron neutron capture therapy. Amsterdam: IOS Press, 2007.
H, Soloway Albert, Barth Rolf F, Carpenter David E. 1943-, International Society for Neutron Capture Therapy., International Union against Cancer, Arthur G. James Cancer Hospital and Research Institute., and International Symposium on Neutron Capture Therapy (5th : 1992 : Columbus, Ohio), eds. Advances in neutron capture therapy. New York: Plenum Press, 1993.
Ross, David Ian. Various studies relating to boron neutron capture therapy. Birmingham: University of Birmingham, 1992.
Hosmane, Narayan S. Boron and gadolinium neutron capture therapy for cancer treatment. Singapore: World Scientific, 2012.
G, Fairchild Ralph, Bond Victor P, and Woodhead Avril D, eds. Clinical aspects of neutron capture therapy. New York: Plenum Press, 1989.
"Hōso Kagōbutsu to Kagaku to 10B Chūseishi Hosoku Ryōhō" Senmon Kenkyūkai. "Hōso Kagōbutsu no Kagaku to 10B Chūseishi Hosoku Ryōhō" dai 8--9--10-kai Senmon Kenkyūkai hōkokusho: Kaisai 1996-nen 2-gatsu 20-nichi, 1997-nen ... Ōsaka-fu Sennan-gun Kumatori-chō: Kyōto Daigaku Genshiro Jikkejo, 1998.
Hagigeorgiou, Dimitris. Theoretical investigation of therapeutic improvements for boron neutron capture therapy. Birmingham: University of Birmingham, 2003.
Book chapters on the topic "Boron-neutron capture therapy":
Yanch, Jacquelyn C. "Boron Neutron Capture Synovectomy." In Neutron Capture Therapy, 521–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31334-9_31.
Nakagawa, Yoshinobu. "Boron Neutron Capture Therapy." In Frontiers in Neutron Capture Therapy, 73–79. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1285-1_6.
Perks, Christopher A., and Howard J. Delafield. "Neutron Spectrometry Measurements of the Petten HFR, HB11 Neutron Beam." In Boron Neutron Capture Therapy, 79–91. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_10.
Mauri, Pier Luigi, and Fabrizio Basilico. "Proteomic Investigations for Boron Neutron Capture Therapy." In Neutron Capture Therapy, 189–200. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31334-9_10.
Kawabata, Shinji, and Shin-Ichi Miyatake. "Boron Neutron Capture Therapy for Malignant Meningiomas." In Neutron Capture Therapy, 399–406. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31334-9_22.
Hondros, E. D. "Opening Speech." In Boron Neutron Capture Therapy, 1–3. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_1.
Raaijmakers, Cornelis P. J., Luc Dewit, Mark W. Konijnenberg, Ben J. Mijnheer, Raymond L. Moss, and Finn Stecher-Rasmussen. "A Semi-Empirical Method of Treatment Planning for Boron Neutron Capture Therapy." In Boron Neutron Capture Therapy, 93–100. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_11.
Watkins, Peter. "Present Status of the Three-Dimensional Treatment Planning Methodologies for the Petten BNCT Facility." In Boron Neutron Capture Therapy, 101–9. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_12.
Coderre, Jeffrey A. "A Phase 1 Biodistribution Study of p-Boronophenylalanine." In Boron Neutron Capture Therapy, 111–21. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_13.
Gahbauer, Reinhard A., Ralph G. Fairchild, Joseph H. Goodman, and Thomas E. Blue. "RBE in Normal Tissue Studies." In Boron Neutron Capture Therapy, 123–28. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_14.
Conference papers on the topic "Boron-neutron capture therapy":
Stecher‐Rasmussen, F., R. L. Moss, and M. W. Konijnenberg. "Boron Neutron Capture Therapy." In Capture gamma‐ray spectroscopy. American Institute of Physics, 1991. http://dx.doi.org/10.1063/1.41154.
Haque, A. M., G. Moschini, Vlado Valkovic, and D. Zafiropoulos. "Boron-neutron capture therapy." In 4th International Conference on Applications of Nuclear Techniques: Neutrons and their Applications, edited by George Vourvopoulos and Themis Paradellis. SPIE, 1995. http://dx.doi.org/10.1117/12.204194.
Gabel, Detlef. "Boron neutron capture therapy: from physics to treatment." In Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, edited by George Vourvopoulos. SPIE, 1997. http://dx.doi.org/10.1117/12.267842.
Kanda, Keiji. "Experience of boron neutron capture therapy in Japan." In Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, edited by George Vourvopoulos. SPIE, 1997. http://dx.doi.org/10.1117/12.267900.
Taskaev, Sergey. "Neutron source VITA for Boron Neutron Capture Therapy and other applications." In RAD Conference. RAD Centre, 2021. http://dx.doi.org/10.21175/rad.abstr.book.2021.16.2.
Herrera, María S., Sara J. González, Daniel M. Minsky, Andrés J. Kreiner, Ricardo Alarcon, Phil Cole, Andres J. Kreiner, and Hugo F. Arellano. "Treatment Planning for Accelerator-Based Boron Neutron Capture Therapy." In VIII LATIN AMERICAN SYMPOSIUM ON NUCLEAR PHYSICS AND APPLICATIONS. AIP, 2010. http://dx.doi.org/10.1063/1.3480233.
Shefer, Ruth E., Robert E. Klinkowstein, and Jacquelyn C. Yanch. "High-current electrostatic accelerator for boron neutron capture therapy." In Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, edited by George Vourvopoulos. SPIE, 1997. http://dx.doi.org/10.1117/12.267922.
Yanch, J. C., R. E. Shefer, R. E. Klinkowstein, W. B. Howard, H. Song, B. Blackburn, and E. Binello. "Research in Boron Neutron Capture Therapy at MIT LABA." In The fourteenth international conference on the application of accelerators in research and industry. AIP, 1997. http://dx.doi.org/10.1063/1.52637.
Singh, Bikramjeet, Paviter Singh, Manjeet Kumar, Anup Thakur, and Akshay Kumar. "Single step synthesis of nanostructured boron nitride for boron neutron capture therapy." In PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON CONDENSED MATTER PHYSICS 2014 (ICCMP 2014). AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4915415.
Kanygin, V. V., A. I. Kichigin, A. L. Krivoshapkin, and S. Yu Taskaev. "Perspectives of boron-neutron capture therapy of malignant brain tumors." In PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17). Author(s), 2017. http://dx.doi.org/10.1063/1.5001609.
Reports on the topic "Boron-neutron capture therapy":
Maughan, R. L., and C. Kota. Microdosimetry for Boron Neutron Capture Therapy. Office of Scientific and Technical Information (OSTI), September 2000. http://dx.doi.org/10.2172/770637.
N. Commercial Clinical Application of Boron Neutron Capture Therapy. Office of Scientific and Technical Information (OSTI), September 1999. http://dx.doi.org/10.2172/942161.
Dolan, T., E. Ottewitte, E. Wills, W. Neuman, and D. Woodall. Non-reactor neutron sources for BNCT (Boron Neutron Capture Therapy). Office of Scientific and Technical Information (OSTI), May 1989. http://dx.doi.org/10.2172/5876401.
Wang, Zhonglu. Design of a boron neutron capture enhanced fast neutron therapy assembly. Office of Scientific and Technical Information (OSTI), December 2006. http://dx.doi.org/10.2172/892403.
Sweezy, Jeremy Ed. Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam. Office of Scientific and Technical Information (OSTI), January 2002. http://dx.doi.org/10.2172/1420958.
J. Vujic, E. Greenspan, W.E. Kastenber, Y. Karni, D. Regev, K. N. Leung J.M. Verbeke, D. Chivers, et al. Optimal Neutron Source & Beam Shaping Assembly for Boron Neutron Capture Therapy. Office of Scientific and Technical Information (OSTI), April 2003. http://dx.doi.org/10.2172/810841.
Barnum, Beverly A., Yan Hao, Roger Moore, M. Frederick Hawthorne, and Kurt Baum. Carborane derivative development for boron neutron capture therapy. Final report. Office of Scientific and Technical Information (OSTI), April 1999. http://dx.doi.org/10.2172/762720.
Dorn, R. V. III. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment. Edited by A. L. Ackermann. Office of Scientific and Technical Information (OSTI), August 1990. http://dx.doi.org/10.2172/6321857.
Ackermann, A. L., ed. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment. Office of Scientific and Technical Information (OSTI), October 1990. http://dx.doi.org/10.2172/6141929.
Dorn, R. V. III. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment. Edited by A. L. Ackermann. Office of Scientific and Technical Information (OSTI), September 1990. http://dx.doi.org/10.2172/6168994.