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1

Wackym, Phillip A. Molecular temporal bone pathology, parts III and IV. Philadelphia, PA: Lippincott-Raven, 1998.

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2

Raisz, Lawrence G. (Lawrence Gideon), 1925-, Martin T. John, and ScienceDirect (Online service), eds. Principles of bone biology. 3rd ed. Amsterdam: Elsevier, 2008.

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3

Rosen, Vicki. The cellular and molecular basis of bone formation and repair. New York: Springer, 1995.

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4

1957-, Thies Robert Scott, ed. The cellular and molecular basis of bone formation and repair. Austin: R.G. Landes, 1995.

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5

Dietz, Georg. Calcium hydroxide and bone regeneration: Odontological aspects of induced osteogenesis in experiment and clinical practice. München: G. Dietz, 1998.

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6

Cardew, Gail. The molecular basis of skeletogenesis. Chichester: Wiley, 2001.

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7

(Foreword), G. A. Rodan, Felix Bronner (Editor), and Mary C. Farach-Carson (Editor), eds. Bone Formation (Topics in Bone Biology). Springer, 2003.

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8

Gurmit, Singh, and Orr F. William, eds. Bone metastasis and molecular mechanisms: Pathophysiology. Dordrecht: Kluwer Academic, 2004.

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9

Orr, William, and Gurmit Singh. Bone Metastasis and Molecular Mechanisms: Pathophysiology. Springer-Verlag New York Inc., 2004.

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10

Singh, Gurmit. Bone Metastasis and Molecular Mechanisms: Pathophysiology. Springer, 2010.

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11

Masaki, Noda, ed. Cellular and molecular biology of bone. San Diego: Academic Press, 1993.

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12

(Editor), Hong-Wen Deng, Yao-zhong Liu (Editor), Chun-Yuan Guo (Editor), and Di Chen (Editor), eds. Current Topics in Bone Biology. World Scientific Publishing Company, 2005.

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13

Hong-wen, Deng, and Liu Yao-zhong, eds. Current topics in bone biology. Singapore: World Scientific, 2005.

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14

Bone mass, menstrual abnormalities, dietary intake, and body composition in classical ballerinas. 1986.

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15

Bone mass, menstrual abnormalities, dietary intake, and body composition in classical ballerinas. 1989.

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16

Bone mass, menstrual abnormalities, dietary intake, and body composition in classical ballerinas. 1989.

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17

The effects of back exercise on bone metabolism in early postmenopausal women. 1987.

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18

The effects of back exercise on bone metabolism in early postmenopausal women. 1987.

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19

The effects of back exercise on bone metabolism in early postmenopausal women. 1985.

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20

Bone mass, menstrual abnormalities, dietary intake, and body composition in classical ballerinas. 1989.

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21

(Editor), Geoffrey Burnstock, and Timothy R. Arnett (Editor), eds. Nucleotides and Regulation of Bone Cell Function. CRC, 2006.

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22

Bone Metastasis and Molecular Mechanisms: Pathophysiology (Cancer Metastasis - Biology and Treatment). Springer, 2004.

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23

Theis, R. Scott, and Vicki Rosen. Cellular & Molec Basis Bone Format (Molecular Biology Intelligence Unit). Springer, 1996.

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24

Principles of Bone Biology. Academic Press, 2002.

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25

Molecular Biology of Hematopoiesis 5. Springer, 2012.

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26

G, Abraham Nader, and Symposium on the Molecular Biology of Hematopoiesis (9th : 1995 : Genoa, Italy), eds. Molecular biology of hematopoiesis 5. New York: Plenum Press, 1996.

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27

The effect of a weight training program on the bone density of women aged 40-50 years. 1994.

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28

(Editor), John P. Bilezikian, Lawrence G. Raisz (Editor), and Gideon A. Rodan (Editor), eds. Principles of Bone Biology, Second Edition (2 Vol. Set). 2nd ed. Academic Press, 2001.

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29

P, Bilezikian John, Raisz Lawrence G. 1925-, and Rodan Gideon A, eds. Principles of bone biology. San Diego: Academic Press, 1996.

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30

The effects of high impact exercise versus low impact exercise on bone density in postmenopausal women. 1990.

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31

(Editor), Joseph A. Buckwalter, Michael G. Ehrlich (Editor), Linda J. Sandell (Editor), and Stephen B. Trippel (Editor), eds. Skeletal Growth and Development: Clinical Issues and Basic Science Advances (The Symposium Series). American Academy of Orthopaedic Surgeons, 1998.

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32

A, Buckwalter Joseph, American Academy of Orthopaedic Surgeons., National Institutes of Health (U.S.), and Orthopaedic Research and Education Foundation., eds. Skeletal growth and development: Clinical issues and basic science advances : workshop, Howey-in-the-Hills, Florida, May 1997. Rosemont, IL: American Academy of Orthopaedic Surgeons, 1998.

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33

Osteoporosis: Methods and Protocols (Methods in Molecular Biology). Humana Press, 2008.

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34

Skeletal Growth Factors. Lippincott Williams & Wilkins, 2000.

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35

Genetics for Orthopedic Surgeons. Remedica Publishing, 2002.

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36

Sheridan, Peter J., and Kenneth Blum. Steroid Receptors and Disease: Cancer, Autoimmune, Bone, and Circulatory Disorders. Marcel Dekker Inc, 1988.

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37

1941-, Sheridan Peter J., Blum Kenneth, and Trachtenberg Michael C. 1941-, eds. Steroid receptors and disease: Cancer, autoimmune, bone, and circulatory disorders. New York: Dekker, 1988.

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38

Cytogenetics, FISH and Molecular Testing in Hematologic Malignancies. Informa Healthcare, 2008.

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39

The Molecular Basis of Skeletogenesis No. 232. Wiley, 2001.

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40

Thomas, Ranjeny, and Andrew P. Cope. Pathogenesis of rheumatoid arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0109.

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In depth molecular and cellular analysis of synovial tissue and fluid from patients with rheumatoid arthritis has provided important insights into understanding disease pathogenesis. Advances in the 1980s and 1990s included modern cloning strategies, sensitive and specific assays for inflammatory mediators, production of high-affinity neutralizing monoclonal antibodies, advances in flow cytometry, and gene targeting and transgenic strategies in rodents. In the 21st century, technological platforms offer unparalleled opportunities for systematic and unbiased interrogation of the disease process at a whole-genome level. Here we describe the key molecular and cellular characteristics of the inflamed synovium and how infiltrating cells get there. With this background, we outline current concepts of the different phases of disease, how the first phase of genetic susceptibility evolves into autoimmunity, triggered by the exposome, prior to the onset of clinically apparent inflammatory disease. We then describe the pathways that actively contribute to this early inflammatory phase and document the key effector cells and molecules of the innate and adaptive immune systems that orchestrate and maintain chronic synovial inflammatory responses. We summarize how this inflammatory milieu translates to cartilage destruction and bone resorption in synovial joints, and conclude by reviewing those factors in inflamed synovium that promote immune homeostasis.
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