Relevant bibliographies by topics / Bone regeneration

Academic literature on the topic 'Bone regeneration'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Bone regeneration.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Bone regeneration"

1

Saberian, Elham, Andrej Jenča, Yaser Zafari, Andrej Jenča, Adriána Petrášová, Hadi Zare-Zardini, and Janka Jenčová. "Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review." Cells 13, no. 12 (June 19, 2024): 1065. http://dx.doi.org/10.3390/cells13121065.

Full text
Abstract:
Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells and targeted 3D scaffolds have been investigated in the search for workable solutions. The use of scaffolds in stem cell-assisted bone regeneration is a crucial component of tissue engineering techniques designed to overcome the drawbacks of traditional bone grafts. This study provides a detailed review of scaffold applications for bone regeneration with stem cells in dentistry. This review focuses on scaffolds and stem cells while covering a broad range of studies explaining bone regeneration in dentistry through the presentation of studies conducted in this field. The role of different stem cells in regenerative medicine is covered in great detail in the reviewed literature. These studies have addressed a wide range of subjects, including the effects of platelet concentrates during dental surgery or specific combinations, such as human dental pulp stem cells with scaffolds for animal model bone regeneration, to promote bone regeneration in animal models. Noting developments, research works consider methods to improve vascularization and explore the use of 3D-printed scaffolds, secretome applications, mesenchymal stem cells, and biomaterials for oral bone tissue regeneration. This thorough assessment outlines possible developments within these crucial regenerative dentistry cycles and provides insights and suggestions for additional study. Furthermore, alternative creative methods for regenerating bone tissue include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser therapy, nutritional supplements and diet, gene therapy, and biomimetic materials. These innovative approaches offer promising avenues for future research and development in the field of bone tissue regeneration in dentistry.
APA, Harvard, Vancouver, ISO, and other styles
2

Funda, Goker, Silvio Taschieri, Giannì Aldo Bruno, Emma Grecchi, Savadori Paolo, Donati Girolamo, and Massimo Del Fabbro. "Nanotechnology Scaffolds for Alveolar Bone Regeneration." Materials 13, no. 1 (January 3, 2020): 201. http://dx.doi.org/10.3390/ma13010201.

Full text
Abstract:
In oral biology, tissue engineering aims at regenerating functional tissues through a series of key events that occur during alveolar/periodontal tissue formation and growth, by means of scaffolds that deliver signaling molecules and cells. Due to their excellent physicochemical properties and biomimetic features, nanomaterials are attractive alternatives offering many advantages for stimulating cell growth and promoting tissue regeneration through tissue engineering. The main aim of this article was to review the currently available literature to provide an overview of the different nano-scale scaffolds as key factors of tissue engineering for alveolar bone regeneration procedures. In this narrative review, PubMed, Medline, Scopus and Cochrane electronic databases were searched using key words like “tissue engineering”, “regenerative medicine”, “alveolar bone defects”, “alveolar bone regeneration”, “nanomaterials”, “scaffolds”, “nanospheres” and “nanofibrous scaffolds”. No limitation regarding language, publication date and study design was set. Hand-searching of the reference list of identified articles was also undertaken. The aim of this article was to give a brief introduction to review the role of different nanoscaffolds for bone regeneration and the main focus was set to underline their role for alveolar bone regeneration procedures.
APA, Harvard, Vancouver, ISO, and other styles
3

Shimono, M., T. Inoue, and T. Yamamura. "Regeneration of Periodontal Tissues." Advances in Dental Research 2, no. 2 (November 1988): 223–27. http://dx.doi.org/10.1177/08959374880020020501.

Full text
Abstract:
To elucidate the regenerative capability of the periodontal tissues, we carried out two experiments: (1) Regeneration of the gingival tissue following gingivectomy in rats. Ultrastructurally, regenerating junctional epithelium was similar in morphology to that of untreated animals and appeared to attach to the enamel after five days. Basal lamina and hemidesmosomes were produced faster at the enamel interface than at the connective tissue interface. Gingival tissue was completely regenerated seven days after the gingivectomy. (2) Regeneration of the cementum, periodontal ligament, and alveolar bone following intradentinal cavity preparation in dogs. In the early stages, the cavity was filled with an exudate and granulation tissue. Seven days after the operation, osteoblasts and cementoblasts were arranged regularly on the cut surface of the alveolar bone and dentin, respectively. Newly formed bone and cementum, and periodontal ligament grew to resemble pre-existing bone and cementum after 28-42 days. From these results, it is suggested that the periodontal tissues have an extremely high capability of regeneration.
APA, Harvard, Vancouver, ISO, and other styles
4

Batwa, Mohammed, Rand Bakhsh, Zainab Alghamdi, Khaled Ageely, Abdullah Alzahrani, Abdullah Alshahrani, Khalid Mujthil, et al. "Regenerative Therapies in the Treatment of Periodontal Defects." JOURNAL OF HEALTHCARE SCIENCES 03, no. 08 (2023): 254–60. http://dx.doi.org/10.52533/johs.2023.30802.

Full text
Abstract:
Regenerative therapies in periodontics have shown great potential in restoring damaged periodontal tissues. Techniques such as guided tissue regeneration (GTR) and guided bone regeneration (GBR) have been effective in promoting the regeneration of periodontal ligament, cementum, and alveolar bone. These approaches create a conducive environment for cell repopulation and exclusion of non-osteogenic cells, leading to successful periodontal tissue regeneration. Tissue engineering approaches, utilizing stem cells, growth factors, and biomaterial scaffolds, have also shown promise in regenerating multiple periodontal tissues simultaneously. However, challenges such as membrane exposure and infection need to be addressed. Emerging regenerative techniques, including enamel matrix derivatives (EMDs), stem cell-based therapies, growth factor delivery systems, and gene therapies, offer innovative strategies for periodontal defect treatment. Optimization of delivery systems, refinement of biomaterials, and advancements in gene therapy and tissue-specific biomaterials may further enhance the regenerative capacity of periodontal tissues. Despite challenges, regenerative therapies have the potential to revolutionize periodontics and improve clinical outcomes by addressing the root cause of periodontal diseases and promoting long-lasting tissue regeneration.
APA, Harvard, Vancouver, ISO, and other styles
5

Delpierre, Alexis, Guillaume Savard, Matthieu Renaud, and Gael Y. Rochefort. "Tissue Engineering Strategies Applied in Bone Regeneration and Bone Repair." Bioengineering 10, no. 6 (May 25, 2023): 644. http://dx.doi.org/10.3390/bioengineering10060644.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Wagner, Johannes Maximilian, Christoph Wallner, Mustafa Becerikli, Felix Reinkemeier, Maxi von Glinski, Alexander Sogorski, Julika Huber, et al. "Role of Autonomous Neuropathy in Diabetic Bone Regeneration." Cells 11, no. 4 (February 10, 2022): 612. http://dx.doi.org/10.3390/cells11040612.

Full text
Abstract:
Diabetes mellitus has multiple negative effects on regenerative processes, especially on wound and fracture healing. Despite the well-known negative effects of diabetes on the autonomous nervous system, only little is known about the role in bone regeneration within this context. Subsequently, we investigated diabetic bone regeneration in db−/db− mice with a special emphasis on the sympathetic nervous system of the bone in a monocortical tibia defect model. Moreover, the effect of pharmacological sympathectomy via administration of 6-OHDA was evaluated in C57Bl6 wildtype mice. Diabetic animals as well as wildtype mice received a treatment of BRL37344, a β3-adrenergic agonist. Bones of animals were examined via µCT, aniline-blue and Masson–Goldner staining for new bone formation, TRAP staining for bone turnover and immunoflourescence staining against tyrosinhydroxylase and stromal cell-derived factor 1 (SDF-1). Sympathectomized wildtype mice showed a significantly decreased bone regeneration, just comparable to db−/db− mice. New bone formation of BRL37344 treated db−/db− and sympathectomized wildtype mice was markedly improved in histology and µCT. Immunoflourescence stainings revealed significantly increased SDF-1 due to BRL37344 treatment in diabetic animals and sympathectomized wildtypes. This study depicts the important role of the sympathetic nervous system for bone regenerative processes using the clinical example of diabetes mellitus type 2. In order to improve and gain further insights into diabetic fracture healing, β3-agonist BRL37344 proved to be a potent treatment option, restoring impaired diabetic bone regeneration.
APA, Harvard, Vancouver, ISO, and other styles
7

Franceschi, R. T. "Biological Approaches to Bone Regeneration by Gene Therapy." Journal of Dental Research 84, no. 12 (December 2005): 1093–103. http://dx.doi.org/10.1177/154405910508401204.

Full text
Abstract:
Safe, effective approaches for bone regeneration are needed to reverse bone loss caused by trauma, disease, and tumor resection. Unfortunately, the science of bone regeneration is still in its infancy, with all current or emerging therapies having serious limitations. Unlike current regenerative therapies that use single regenerative factors, the natural processes of bone formation and repair require the coordinated expression of many molecules, including growth factors, bone morphogenetic proteins, and specific transcription factors. As will be developed in this article, future advances in bone regeneration will likely incorporate therapies that mimic critical aspects of these natural biological processes, using the tools of gene therapy and tissue engineering. This review will summarize current knowledge related to normal bone development and fracture repair, and will describe how gene therapy, in combination with tissue engineering, may mimic critical aspects of these natural processes. Current gene therapy approaches for bone regeneration will then be summarized, including recent work where combinatorial gene therapy was used to express groups of molecules that synergistically interacted to stimulate bone regeneration. Last, proposed future directions for this field will be discussed, where regulated gene expression systems will be combined with cells seeded in precise three-dimensional configurations on synthetic scaffolds to control both temporal and spatial distribution of regenerative factors. It is the premise of this article that such approaches will eventually allow us to achieve the ultimate goal of bone tissue engineering: to reconstruct entire bones with associated joints, ligaments, or sutures. Abbreviations used: BMP, bone morphogenetic protein; FGF, fibroblast growth factor; AER, apical ectodermal ridge; ZPA, zone of polarizing activity; PZ, progress zone; SHH, sonic hedgehog; OSX, osterix transcription factor; FGFR, fibroblast growth factor receptor; PMN, polymorphonuclear neutrophil; PDGF, platelet-derived growth factor; IGF, insulin-like growth factor; TGF-β, tumor-derived growth factor β; CAR, coxsackievirus and adenovirus receptor; MLV, murine leukemia virus; HIV, human immunodeficiency virus; AAV, adeno-associated virus; CAT, computer-aided tomography; CMV, cytomegalovirus; GAM, gene-activated matrix; MSC, marrow stromal cell; MDSC, muscle-derived stem cell; VEGF, vascular endothelial growth factor.
APA, Harvard, Vancouver, ISO, and other styles
8

Petrović, Milica, Ljiljana Kesić, Radmila Obradović, Simona Stojanović, Branislava Stojković, Marija Bojović, Ivana Stanković, Kosta Todorović, Milan Spasić, and Nenad Stošić. "Regenerative periodontal therapy: I part." Acta stomatologica Naissi 37, no. 84 (2021): 2304–13. http://dx.doi.org/10.5937/asn2184304p.

Full text
Abstract:
Introduction: Under the concept of regenerative periodontal therapy, there are two approaches: the first is the passive regeneration conceptthat includes bone substituents and guided periodontal regeneration by using of biomembranes and the second concept of active regeneration that impliesthe use of growth factors. The aim of the passive regeneration, by using of bone matrix (bone substituens) has been stabilization and bone defects management, preventing epithelial tissue growth, as well as saving space for the new tissue regeneration. This concept implies the use of autogenous transplantats, xenografts, allografts, as well as alloplastic materials. The carriers for active tissue regeneration, growth factors -GF are biological mediators that regulate cellular processes and that is crucial for the tissue regeneration. Aim:Presentation ofmodern approaches to periodontal therapy thatare focused on the attachment regeneration and complete reconstruction of periodontal tissue. Conclusion: In the future, periodontal regenerative therapy with periodontalligament progenitor cells should encourage repopulation of the areas that have been affected by periodontal disease.
APA, Harvard, Vancouver, ISO, and other styles
9

Yahav, Amos, Gregori M. Kurtzman, Michael Katzap, Damian Dudek, and David Baranes. "Bone Regeneration." Dental Clinics of North America 64, no. 2 (April 2020): 453–72. http://dx.doi.org/10.1016/j.cden.2019.12.006.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Malysheva, Kh V., I. M. Spasyuk, O. K. Pavlenko, R. S. Stoika, and O. G. Korchynsky. "Generation of optimized preparations of bone morphogenetic proteins for bone regeneration." Ukrainian Biochemical Journal 88, no. 6 (December 14, 2016): 87–97. http://dx.doi.org/10.15407/ubj88.06.087.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Bone regeneration"

1

Åkesson, Kristina. "Fracture and biochemical markers of bone metabolism." Lund : University of Lund, Dept. of Orthopaedics, Malmö General Hospital, Sweden, 1995. http://books.google.com/books?id=Ib9qAAAAMAAJ.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Kolambkar, Yash Manohar. "Electrospun nanofiber meshes for the functional repair of bone defects." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37196.

Full text
Abstract:
Bone defects caused by trauma, tumor resection or disease present a significant clinical problem. Failures in 'high risk' fractures and large bone defects have been reported to be as high as 30-50%. The drawbacks associated with current bone grafting procedures have stimulated the search for improved techniques for bone repair. Tissue engineering/regenerative medicine approaches promote tissue repair by providing a combination of physical and biological cues through structural scaffolds and bioactive agents. Though they have demonstrated significant promise for bone regeneration, very little has been translated to clinical practice. The goal of this thesis was to investigate the potential of electrospun nanofiber mesh scaffolds for bone regeneration. Nanofiber meshes were utilized in a three-pronged approach. First, we validated their ability to robustly support osteogenic cell functions, including proliferation and matrix mineralization. We also demonstrated their efficacy as a cell delivery vehicle. Second, we investigated the effects of modulating nanofiber bioactivity and orientation on stem cell programming. Our results indicate that functionalization of nanofiber meshes with a collagen-mimetic peptide enhanced the migration, proliferation and osteogenic differentiation of cells. Fiber alignment improved cell migration along the direction of fiber orientation. Finally, a nanofiber mesh based hybrid system for growth factor delivery was developed for bone repair and tested in a challenging animal model. The delivery of bone morphogenetic protein (BMP) via this system resulted in the functional restoration of limb function, and in fact proved more efficacious than the current clinical standard for BMP delivery. The studies performed in this thesis have suggested novel techniques for improving the repair of clinically challenging bone defects. They indicate that the delivery of BMP via the hybrid system may reduce the dose and side effects of BMP, thereby broadening the use of BMP based bone augmentation procedures. Therefore, this nanofiber mesh based system has the potential to become the standard of care for clinically challenging bone defects, including large bone defects, open tibial fractures, and nonunions.
APA, Harvard, Vancouver, ISO, and other styles
3

黃美娟 and May-kuen Alice Wong. "Bone induction of demineralized intramembranous and endochondral bone matrices." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B3197305X.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Wong, May-kuen Alice. "Bone induction of demineralized intramembranous and endochondral bone matrices." View the Table of Contents & Abstract, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21872752.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Pal, George L. "Guided Bone Regeneration Around Titanium Implants." University of Sydney, 1996. http://hdl.handle.net/2123/5050.

Full text
Abstract:
Master of Science in Dentistry
This work was digitised and made available on open access by the University of Sydney, Faculty of Dentistry and Sydney eScholarship . It may only be used for the purposes of research and study. Where possible, the Faculty will try to notify the author of this work. If you have any inquiries or issues regarding this work being made available please contact the Sydney eScholarship Repository Coordinator - ses@library.usyd.edu.au
APA, Harvard, Vancouver, ISO, and other styles
6

Nkhwa, Shathani. "Hydrogel biocomposites for bone tissue regeneration." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/hydrogel-biocomposites-for-bone-tissue-regeneration(ad423107-672f-4269-9aa0-5e4eb949dfd5).html.

Full text
Abstract:
The biomedical burden of large bone defects caused by trauma, infection, tumours or inherent genetic disorders remains a clinical challenge. Autologous bone or autograft continue to be the clinical “gold standard” for most effective bone regeneration, which is limited by bone supply and donor site morbidity. Thus, current synthetic substitutes need to be improved to match the performance of autografts. Bone tissue engineering is an attractive approach for regeneration of bone especially in relation to critical sized defects and a scaffold with osteoinductive properties and adequate mechanical properties is expected to enhance bone formation. The aim of the study is to enhance bone regeneration and the concept is based on adequate design of three dimensional scaffolds that mimic the structure of bone, which by virtue of its inherent properties have the ability to localise fluids rich in osteoinductive factors. The hydrogels and composites were all synthesized with a base polymer polyvinyl alcohol (PVA), which is both robust, biocompatible and FDA approved material. Facile methods of crosslinking such as air-drying and freeze-drying which introduces a level of porosity in the materials due to the lyophilisation process, were used to render the hydrogels insoluble, and conditions optimised to yield materials with properties suitable for soft bone tissue applications. PVA hydrogels were synthesized and characterised, results indicated that water uptake, glass transition and tensile strength were influenced by varying concentration of the polymer solution. A new type of dual network (DN) hydrogel composed of PVA and alginate was developed and optimised. Characterisations by spectral and thermal analysis, confirmed incorporation of alginate within the PVA network structure. Hydration dynamics and tensile properties, indicated that DN formed from a PVA base crosslinked by two freeze thaw cycles yielded tough hydrogels with controlled swelling, making them suitable for soft tissue applications as well as the diversity of being further incorporated with ceramic fillers for the development of bone composite substitutes. Incorporation of bioglass® 45S5 within the polymeric network structure of the DN led to enhancement of the mechanical properties such as tensile strength and fracture toughness as well as imparting bioactivity within the hydrogel composites, which was demonstrated by the development of hydroxy carbonated apatite on the surface and internal structure of the composites, this result was further corroborated by the increase in tensile strength and stiffness of the composites when placed in simulated body fluid over a period of 28 days. The second group of hydrogel composites was composed of a PVA fluid phase and calcium metaphosphate (CMP) ceramic phase, crosslinked by freeze drying. This hydrogel composite was developed to have a high mineral content with properties that closely resemble the properties of bone based on its inorganic/organic nanocomposite structure. Compression and water uptake behaviour of the composite could be modulated by varying concentration of PVA and the composite system properties were found to be suitable and lie within the range values for trabecular bone. In vitro cell culture tests were used to assess biocompatibility and the selected scaffolds were seeded with human osteoblast cells (HOB) and were evaluated by MTT, and live dead staining. All the systems were found to be biocompatible and cells were able to attach and proliferate within the scaffolds. Biofunctionality was assessed on the scaffolds which all showed a peak increase in alkaline phosphatase activity (ALP) at day 14, an important bone marker indicating osteoblast differentiation.
APA, Harvard, Vancouver, ISO, and other styles
7

Uswatta, Suren Perera. "Injectable Particles for Craniofacial Bone Regeneration." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1481305175641452.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Marbelia, Lisendra. "Chitosan based scaffolds for bone regeneration." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7459.

Full text
Abstract:
Mestrado em Ciência e Engenharia de Materiais
Tissue engineering research attempts to satisfy the needs of support, reinforcement and in some cases organization of the regenerating tissue with a controlled supply of bioactive substances that might positively influence the behaviour of incorporated or ingrowing cells. As demonstrated by the recent advances on biomaterials, the ideal scaffold for tissue regeneration should offer a 3D interconnected porous structure behaving as a template to promote cells adhesion and proliferation and vascularisation as well thus stimulating the new tissue ingrowth. A special interest has been focused on chitosan (CH - the partially deacetylated derivative of chitin) scaffolds for bone regeneration due to its biological and physical properties, in spite of some drawbacks regarding its lack of mechanical strength and bioactivity. The incorporation of bioactive calcium phosphates materials in the polymer matrix is expected to reinforce chitosan scaffolds improving their mechanical performance and osteoconductivity. In the present work, chitosan based scaffolds were produced by freeze-drying CH solutions containing calcium phosphate (CaP) particles, either as fibers of hydroxyapatite (HA), platelets of monetite or a mixture of both. CaP particles were prepared by a wet precipitation method. The calcium phosphate precipitation was monitored by taking a number of samples during 3-days. Evolution of the morphology and crystal phase composition of the precipitated particles were followed by scanning electron microscopy (SEM), N2 adsorption using the BET isotherm (BET), and X-ray diffraction (XRD). It was observed that the increase of refluxing temperature allowed a faster transformation of octacalcium phosphate fibers into HA fibers, hence shortening the precipitation time required for obtaining HA fibers, Chitosan based scaffolds suspensions at two different pH values were frozen at three different temperatures before freeze-drying (thermally induced phase separation-TIPS). SEM, XRD, microcomputed tomography (μ-CT) and Fourier transformed infrared spectroscopy (FTIR) were used to analyze the physical and chemical properties of the composite scaffolds. Compressive mechanical tests were also undertaken to characterize the materials. Bioactivity studies were performed in simulated body fluid (SBF) solutions by monitoring the Ca and P concentration variations of SBF solutions. Highly interconnected macroporous scaffolds with a pore size ranging from of 50 to 250μm, interconnectivity around 91-98.5%, and porosity higher than 80% were obtained. The freezing temperature and the pH of chitosan solution/suspension revealed to play a significant influence in the pore structure. The higher pH (pH=5) and the higher freezing temperature (T=0ºC) were found as the most favourable conditions for ice crystal growth which resulted in larger pores. It was also observed that CaP particles incorporation in the CH matrix increased the scaffold mechanical strength which was also conditioned by the pore size and by the reinforcing particle morphology. The bioactivity studies revealed the CaP contribution for the scaffold bioactivity. The composite scaffolds having brushite and HA (obtained at pH=2) exhibited enhanced bioactivity as compared to composite CH/HA scaffolds based. CH based scaffolds were also prepared by incorporating HA granules loaded with dexamethasone (DEX), a drug model, in CH solution. The granules were obtained by spray drying HA nanosized particles suspended in DEX solution. The drug release profiles of DEX were determined in phosphate-buffered solution (PBS) by DEX concentration evaluation in the releasing medium by Ultraviolet (UV) spectroscopy at the wavelength of 242 nm. Among the different DEX release patterns corresponding to the various DEX loading methodologies which were tested, an adequate release profile could be selected: it showed that the release of 80% of the DEX loaded amount could be ensured during ~30 days, thus enabling a prolonged and slowest DEX release as compared to literature reports. It is thus found that the CH scaffolds engineered with a calcium phosphate based drug delivery system (DDS) provides the desirable association of a bioactive and osteoconductive matrix with an in situ controlled release of a therapeutic agent. These results point out an additional potential of the composite CH/HA scaffolds for behaving as a controlled drug release system (DDS).
A investigação em engenharia de tecidos (ET) tem procurado soluções para as necessidades de reforço e de regeneração dos tecidos recorrendo por vezes a substâncias bioactivas que podem favorecer a proliferação celular. Os avanços recentes em ET têm beneficiado da utilização de matrizes tridimensionais porosas (scaffolds) que permitem a adesão, proliferação e regeneração das células bem como a vascularização, estimulando a formação de novo tecido. A obtenção de scaffolds de quitosano (CH) para a regeneração óssea tem merecido especial interesse devido às suas propriedades biológicas e físicas, apresentando no entanto o inconveniente da falta de resistência mecânica e de bioatividade. A obtenção de scaffolds compósitos por incorporação na matriz polimérica de materiais bioactivos de fosfato de cálcio, permite reforçar o scaffold, melhorando o seu desempenho mecânico e a sua osteocondutividade. No presente trabalho, produziram-se scaffolds compósitos de quitosano/hidroxiapatite por processos de congelamento e liofilização de suspensões de fosfatos de cálcio (CaP) em soluções de CH. Utilizaramse CaP sintetizados laboratorialmente, quer na forma de fibras de hidroxiapatite (HA), quer de lamelas de monetite, quer de mistura dos dois. Os CaP foram sintetizados por um método de precipitação em meio aquoso, tendo-se monitorizado a precipitação de fosfato de cálcio durante 3 dias. Avaliou-se a evolução das fases cristalinas e da morfologia das partículas precipitadas por microscopia eletrónica de varrimento (SEM), difracção de raios X (XRD) e por adsorção de N2 usando a isotérmica de BET. Os resultados evidenciaram que o aumento da temperatura de refluxo acelera a transformação das fibras de octacalcium fosfato em fibras de HÁ, permitindo reduzir o tempo de precipitação total para obtenção de fibras de HA As soluções de quitosano e as suspensões de HAP em solução de CH, a dois valores de pH (pH=2 e pH= 5), foram congeladas a três temperaturas diferentes antes de serem liofilizadas. Caracterizaram-se os scaffolds por SEM, DRX, microtomografia computorizada (μ-CT) e espectroscopia de infravermelhos com transformada de Fourier (FTIR), tendo-se ainda avaliado o seu comportamento mecânico em compressão. Obtiveram-se scaffolds compósitos macroporosos com porosidade superior a 80%, tamanho de poro na gama 50-250μm e porosidade interconectada com grau de interconexão de 91-98.5%. Verificou-se que o tamanho e morfologia de poro dos scaffolds é condicionado pelo pH das suspensões e pela temperatura de congelamento. O valor de pH mais elevado (pH=5) e a temperatura de congelamento mais elevada (T=0ºC) são as condições que mais favorecem o crescimento de cristais de gelo e por conseguinte a formação de poros de maior dimensão. Verificou-se também que a incorporação de partículas de CaP na matriz polimérica de CH aumenta a resistência mecânica do scaffold, que é também condicionada pelo tamanho de poro e pela morfologia da partícula de CaP. O estudo do comportamento bioactivo dos scaffolds compósitos em soluções simuladoras do plasma humano (SBF), monitorizando a variação das concentrações de Ca e P na solução de SBF, evidenciou o contributo das partículas de CaP para a bioactividade do scaffold. Os scaffolds compósitos em que coexistem brushite e HA (preparados a pH=2) evidenciaram bioactividade superior á dos scaffolds compósitos CH/HA. Preparam-se também scaffolds incorporando grânulos de hidroxiapatite carregados com um fármaco modelo, a dexametasona (DEX), na solução inicial de CH. Os grânulos obtiveram-se por atomização de suspensões de HA nanométrica em solução de DEX. Construíram-se os perfis de libertação da DEX em solução tampão fosfato (PBS) por determinação da concentração de DEX por espectroscopia de ultravioleta (UV) ao comprimento de onda de 242 nm. Entre as várias curvas de libertação de DEX decorrentes das diferentes metodologias testadas para carregamento do fármaco, evidenciou-se um perfil de libertação de DEX segundo o qual cerca de 80% da DEX é libertado ao longo de ~30 dias, assegurando-se assim uma libertação mais lenta e prolongada do que as referidas na literatura para a DEX As características dos scaffolds compósitos preparados no presente trabalho apontam os materiais produzidos como promissores para aplicação em engenharia de tecidos, apresentando como potencial adicional a capacidade de se comportarem como sistemas de libertação controlada de fármacos.
APA, Harvard, Vancouver, ISO, and other styles
9

Ma, Li. "The influence of nicotine on angiogenesis and osteogenesis in bone regeneration." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508440.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Ma, Li, and 马丽. "The influence of nicotine on angiogenesis and osteogenesis in bone regeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508440.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Bone regeneration"

1

Tal, Haim. Bone regeneration. Rijeka: InTech, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Katthagen, Bernd-Dietrich. Bone Regeneration with Bone Substitutes. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71827-4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Planell, Josep A. Bone repair biomaterials. Cambridge: Woodhead, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Lieberman, Jay R., and Gary E. Friedlaender, eds. Bone Regeneration and Repair. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1592598633.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Pham, Phuc Van, ed. Bone and Cartilage Regeneration. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40144-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Sela, Jona J., and Itai A. Bab, eds. Principles of Bone Regeneration. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-2059-0.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

E, Seyfer Alan, and Hollinger Jeffrey O, eds. Bone repair and regeneration. Philadelphia: Saunders, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Sela, Jona J. Principles of Bone Regeneration. Boston, MA: Springer US, 2012.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Calandrelli, Luigi. Biodegradable composites for bone regeneration. New York: Nova Science Publishers, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Vukicevic, Slobodan, and Kuber T. Sampath, eds. Bone Morphogenetic Proteins: Regeneration of Bone and Beyond. Basel: Birkhäuser Basel, 2004. http://dx.doi.org/10.1007/978-3-0348-7857-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Bone regeneration"

1

Hollinger, Jeffrey, and Michael H. Mayer. "Bone Regeneration." In Distraction of the Craniofacial Skeleton, 3–19. New York, NY: Springer New York, 1999. http://dx.doi.org/10.1007/978-1-4612-2140-1_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Reddi, A. H. "Bone Regeneration." In Stem Cell and Gene-Based Therapy, 195–201. London: Springer London, 2006. http://dx.doi.org/10.1007/1-84628-142-3_13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Yousefiasl, Satar, Mahsa Imani, Iman Zare, Selva Samaei, Reza Eftekhar Ashtiani, and Esmaeel Sharifi. "Bone Regeneration." In ACS Symposium Series, 109–36. Washington, DC: American Chemical Society, 2023. http://dx.doi.org/10.1021/bk-2023-1438.ch008.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Fujishiro, Takaaki, Hideo Kobayashi, and Thomas W. Bauer. "Autograft Bone." In Musculoskeletal Tissue Regeneration, 65–79. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-239-7_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Wolfinbarger, Lloyd, Liisa M. Eisenlohr, and Katrina Ruth. "Demineralized Bone Matrix: Maximizing New Bone Formation for Successful Bone Implantation." In Musculoskeletal Tissue Regeneration, 93–117. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-239-7_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Umeda, Hiroo. "Cranial Bone Regeneration." In Regenerative Medicine in Otolaryngology, 199–208. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-54856-0_13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Hernandez, Laura Guadalupe, Lucia Pérez Sánchez, Rafael Hernández González, and Janeth Serrano-Bello. "Craniofacial Regeneration—Bone." In Current Advances in Oral and Craniofacial Tissue Engineering, 120–38. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429423055-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Mathias, Dietger. "Continuous Bone Regeneration." In Fit and Healthy from 1 to 100 with Nutrition and Exercise, 177–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-65961-8_84.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Kikuchi, Masanori, and Junzo Tanaka. "Bone Regeneration Materials." In Advanced Biomaterials VII, 277–80. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.277.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Boyan, Barbara D., Ramsey C. Kinney, Kimberly Singh, Joseph K. Williams, Yolanda Cillo, and Zvi Schwartz. "Bone Morphogenetic Proteins and Other Bone Growth Factors." In Musculoskeletal Tissue Regeneration, 225–45. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-239-7_11.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Bone regeneration"

1

Winn, Shelley R., Yunhua Hu, Amy Pugh, Leanna Brown, Jesse T. Nguyen, and Jeffrey O. Hollinger. "Engineered matrices for bone regeneration." In BiOS 2000 The International Symposium on Biomedical Optics, edited by Donald D. Duncan, Jeffrey O. Hollinger, and Steven L. Jacques. SPIE, 2000. http://dx.doi.org/10.1117/12.388078.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Viana, Tania, Sara Biscaia, Henrique A. Almeida, and Paulo J. Bártolo. "PCL/Eggshell Scaffolds for Bone Regeneration." In ASME 2014 12th Biennial Conference on Engineering Systems Design and Analysis. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/esda2014-20213.

Full text
Abstract:
Eggshell (ES) is one of the most common biomaterials in nature. For instance, the ES represents 11% of the total weight of a hen’s egg and it is composed of calcium carbonate, magnesium carbonate, tricalcium phosphate and organic matter. Hen ES are also a major waste product of the food industry worldwide. Recently, ES have been used for many applications such as coating pigments for inkjet printing paper, catalyst for biodiesel synthesis, bio-fillers for polymer composites and matrix lipase immobilization. It is also considered a natural biomaterial with high potential for the synthesis of calcium enriched implants that may be applied in tissue engineering applications, such as bone regeneration. The aim of this research regards the production of poly(ε-caprolactone) (PCL) scaffolds enriched with hen ES powder for bone regeneration applications, using an extrusion-based process called Dual-Bioextruder. The main objective is to investigate the influence of the addition of ES powder on the PCL matrix. For this purpose the structures were characterised regarding morphological and chemical properties. Morphological images of the PCL scaffolds enriched with hen ES, demonstrated the interconnectivity of the pores within the scaffold and revealed that the addition of the ES powder combined with the screw rotation velocity has a large influence on the resulting filament diameter and consequently on the porosity of the scaffolds.
APA, Harvard, Vancouver, ISO, and other styles
3

Lin, Charles P. "Optical Techniques for Studying Bone Regeneration and Bone Marrow Transplantation." In Biomedical Optics. Washington, D.C.: OSA, 2014. http://dx.doi.org/10.1364/biomed.2014.bw1a.1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Sampson, Alana C., Eunna Chung, and Marissa Nichole Rylander. "Thermal Stress Conditioning to Induce Osteogenic Protein Expression for Bone Regeneration." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80940.

Full text
Abstract:
Although bone has the intrinsic ability to “self-heal”, there are circumstances in which its regenerative capacity is limited or compromised, such as in critical bone defects. In these cases, the lack of osteogenic proteins at the wound site can prevent healing and external stimuli may be necessary to encourage bone growth [1]. Exogenous delivery of proteins and growth factors directly to the wound has been successful in bone regeneration, but is limited by the instability of the proteins and short half-lives. As a result, administration of multiple large doses of protein is necessary to retain a beneficial protein level. Due to these disadvantages, additional methods have been investigated to supply essential proteins to the bone defect [2].
APA, Harvard, Vancouver, ISO, and other styles
5

Chung, Eunna, and Marissa Nichole Rylander. "Effects of Growth Factors and Stress Conditioning on the Induction of Heat Shock Proteins and Osteogenesis." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206662.

Full text
Abstract:
Tissue engineering is an emerging field that focuses on development of methods for repairing and regenerating damaged or diseased tissue. Successful development of engineered tissues is often limited by insufficient cellular proliferation and insufficient formation of extracellular matrix. To induce effective bone regeneration, many research groups have investigated the cellular response and capability for tissue regeneration associated with bioreactor conditions and addition of growth factors [1]. Bioreactors in tissue engineering have been developed to expose cells to a similar stress environment as found within the body or induce elevated stress levels for potential induction of specific cellular responses associated with tissue regeneration. Native bone encounters a diverse array of dynamic stresses such as shear, tensile, and compression daily. Stress conditioning protocols in the form of thermal or tensile stress have been shown to induce up-regulation of molecular chaperones called heat shock proteins (HSPs) and bone-related proteins like MMP13 (matrix metallopeptidase 13) [2] and OPG (osteoprotegerin) [3, 4]. HSPs have important roles in enhancing cell proliferation and collagen synthesis. Osteogenic growth factors such as TGF-β1 (transforming growth factor beta 1) and BMP-2 (bone morphogenetic protein 2) are related to bone remodeling and osteogenesis as well as HSP induction [5]. Therefore, identification of effective preconditioning using growth factors and stress protocols that enhance HSP expression could substantially advance development of bone regeneration. The purpose of this research was to identify preconditioning protocols using osteogenic growth factors and tensile stress applied through a bioreactor system to enhance expression of HSPs and bone-related proteins while minimizing cellular injury for ultimate use for bone regeneration.
APA, Harvard, Vancouver, ISO, and other styles
6

Chang, Jiang, and Lei Chen. "Silicate-based Bioactive Materials for Bone Regeneration." In In Commemoration of the 1st Asian Biomaterials Congress. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812835758_0022.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Alvarez-Lorenzo, Carmen. "Cyclodextrins as multipurpose materials for bone regeneration." In The 1st International Electronic Conference on Pharmaceutics. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecp2020-08688.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Rainer, Alberto, Pamela Mozetic, Sara M. Giannitelli, Dino Accoto, Stefano De Porcellinis, Eugenio Guglielmelli, and Marcella Trombetta. "Computer-aided tissue engineering for bone regeneration." In 2012 4th IEEE RAS & EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob 2012). IEEE, 2012. http://dx.doi.org/10.1109/biorob.2012.6290894.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Guo, Yuxuan. "Mechanism of exendin-4 promoting bone regeneration." In Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), edited by Alan Wang. SPIE, 2024. http://dx.doi.org/10.1117/12.3013156.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Setyawati, Ernie Maduratna, and Nahdhiya Amalia Puspita Klana. "Concise review: Periodontal tissue regeneration using pericardium membrane as guided bone regeneration." In THE 2ND INTERNATIONAL CONFERENCE ON PHYSICAL INSTRUMENTATION AND ADVANCED MATERIALS 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0036635.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Bone regeneration"

1

Mehta, Samir, and Kurt Hankenson. Notch Signaling in Bone Regeneration. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada564010.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Yang, Yunzhi P. Optimizing Segmental Bone Regeneration Using Functionally Graded Scaffolds. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada575694.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Kacena, Melissa, Jeffrey Anglen, and Tien-Min Chu. Novel Therapy for Bone Regeneration in Large Segmental Defects. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada612706.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gerasimova, Daria, and Olga Moskalyuk. Comparison of mechanical properties of modern polymer composites used for bone tissue regeneration. Peeref, July 2023. http://dx.doi.org/10.54985/peeref.2307p9375273.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Bumgardner, Joel D. Dual Delivery of Growth Factors and or Antibiotics from Chitosan-Composites for Bone Regeneration. Fort Belvoir, VA: Defense Technical Information Center, October 2010. http://dx.doi.org/10.21236/ada532903.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Franceschi, Renny. A Novel Approach to Regeneration of Bone: Using Focused Ultrasound for the Spatiotemporal Patterning of Angiogenic and Osteogenic Factors. Fort Belvoir, VA: Defense Technical Information Center, April 2012. http://dx.doi.org/10.21236/ada570377.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Baylink, David J. Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implications in Fracture Repair and Wound Healing in Humans. Fort Belvoir, VA: Defense Technical Information Center, October 2003. http://dx.doi.org/10.21236/ada420947.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Baylink, David J. Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implications in Fracture Repair and Wound Healing in Humans. Fort Belvoir, VA: Defense Technical Information Center, October 2000. http://dx.doi.org/10.21236/ada391335.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Mohan, Subburaman. Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implication in Fracture Repair and Wound Healing in Humans. Fort Belvoir, VA: Defense Technical Information Center, April 2008. http://dx.doi.org/10.21236/ada482393.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Cotillo, Luis, Antony Tello, Patricia Horna, Andrea Lopez, and Marco Alarcon. Efficacy of the enamel matrix derivative in guided tissue regeneration with bone substitutes in intraosseous periodontal defects: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2024. http://dx.doi.org/10.37766/inplasy2024.2.0008.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Bone regeneration' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography