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Dissertations / Theses on the topic 'Bone physiology and vitamin A'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Oreffo, R. O. C. "Vitamin A and bone." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376950.

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2

Naja, Roy Pascal. "The role of Vitamin D metabolic enzymes in bone development and repair /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115860.

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The CYP27B1 enzyme that synthesizes 1alpha,25-(OH) 2D, is expressed in chondrocytes, suggesting that local production of 1alpha,25-(OH)2D could play an autocrine or paracrine role in the differentiation of these cells. To test this hypothesis, we have engineered mutant mice that do not express the Cyp27b1 gene in chondrocytes. This led to increased width of the hypertrophic zone of the growth plate at E15.5, increased bone mass in neonatal long bones, and increased expression of the chondrocytic differentiation markers Indian Hedgehog and PTH/PTHrP receptor. VEGF mRNA levels were decreased, ac
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3

Anderson, Paul Hamill. "The regulation of Vitamin D metabolism in the kidney and bone." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09pha5486.pdf.

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Includes bibliographical references (leaves 226-273.) Investigates the regulation of the expression of CYP27B1, CYP24 and vitamin D receptor (VDR) mRNA, both in the bone and in the kidney, with the aim to determine whether the regulation of the vitamin D metabolism in the bone is independent from that in the kidney. The effects of age, dietary calcium and vitamin D status on the expression of these genes in both the kidney and the bone, as well as on a number of biochemical factors known to regulate the renal metabolism of 1,25D, such as PTH, calcium and 1,25D itself, were examined. CYP27B1 mR
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4

Sparks, Patricia Lynne. "The relationship of vitamin D and selected nutrient intakes, sex hormone binding globulin and markers of bone turnover to bone mineral density in exercising and non-exercising postmenopausal women taking or not taking HRT." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/289711.

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The loss of bone mineral density (BMD) plays a major role in the increased incidence of osteoporosis in aging women and, consequently, strategies to maintain BMD are critical to quality of life for these women. The role of vitamin D in the accrual and maintenance of bone mineral and its relationship to the incidence and severity of osteoporosis is not well understood. By measuring serum and intake levels this study investigates the relationship of vitamin D to baseline BMD and changes in regional and total body BMD over 1 y. The role of sex hormone binding globulin (SHBG) is also investigated.
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5

Clements, M. R. "The physiology economy of vitamin D." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47002.

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6

Hall, Judith. "Physiology and pathophysiology of vitamin D metabolism." Thesis, University of Newcastle upon Tyne, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377459.

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7

Barron, Mary Anne. "Vitamin K deficiency in paediatric bone marrow transplantation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0008/MQ40822.pdf.

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8

Laird, Eamon John. "Vitamin D status and metabolism : implications for bone health." Thesis, Ulster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674922.

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In addition to its established role in bone health, vitamin D (2S(OH)D) may also have a role in modulating immune function and early life development. Despite recent advances, there is a lack of consensus with regards to the optimal vitamin D cut-offs for multiple health outcomes and this uncertainty is further compounded by the wide measurement variability for the vitamin. Consequently, the work described in this thesis aimed to explore these areas of controversy. Using data from ongoing studies at the University of Ulster, a comparison study (n 131), of vitamin D status in the two most widel
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9

Blackwell, Penelope J. "Bone turnover in hyperprolactinaemic states." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366417.

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10

Charras, Guillaume. "Cellular mechano-transduction in bone." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269783.

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11

Shum, Laura C. "Mitochondrial Metabolism in Bone Physiology and Pathology." Thesis, University of Rochester, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10792056.

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<p> Worldwide, 1 in 3 women and 1 in 5 men over age 50 will experience fractures due to a decline in bone quality. Elucidating the mechanisms for declining bone quality can lead to better therapeutics. A vital, yet overlooked aspect of bone health is the role of mitochondrial metabolism in both bone physiology and pathology. We have found that the ability of stem cells to differentiate into bone forming osteoblasts is sensitive to mitochondrial dysfunction, and therefore preserving mitochondrial function is essential to maintaining bone quality. In human patient samples, we found that osteogen
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12

Bitton, Ariel. "The role of vitamin D and vitamin D analogues in gene regulation and potentiation of immune response to «Mycobacterium tuberculosis»." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95188.

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1,25-dihydroxyvitamin D3 (1,25D) is the hormonally active form of vitamin D, a key factor in calcium (Ca2+) homeostasis. 1,25D has also been shown to mediate a number of other physiological mechanisms. Here we pay special attention to the immunoregulatory properties of 1,25D, and its role in stimulating immune responses against pathogenic infection. The innate branch of the immune system is responsible for the rapid, non-specific host response against pathogenic infection. 1,25D induces the expression of antimicrobial peptides, which serve as the vanguards of innate immune response as pre
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13

Wakley, Glenn Keith. "Space flight and bone." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246296.

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14

Bannerman, Alistair L. "Imaging the development of a bone-to-bone ligament construct." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6425/.

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Ligament injuries are commonplace, with poor native healing leaving injury sites exposed to instability and further damage. A number of surgical methods have been established for reconstruction using a range of materials, but these have a high failure rate and a number of undesirable side-effects. Much recent work has been focused on the development of tissue engineered ligament grafts. One of the major challenges for this is the formation of an effective ligament-bone interface. In native tissue a multi-phase interface enables smooth transfer of forces between the mechanically mismatched bone
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15

New, Susan A. "An epidemiological investigation into the influence of nutritional factors on bone mineral density and bone metabolism." Thesis, University of Aberdeen, 1995. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602275.

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A food frequency questionnaire (FFQ) was developed for a study investigating dietary influences on bone mineral density (BMD) and bone metabolism (BM). The percentage contribution of food groups to nutrients of interest were identified from 20 7d weighed records (WR) and incorporated to form a 98 food item FFQ. The FFQ was validated against a further 20 7d WR, and the short (6 weeks) and long-term (1 year) reproducibility tested. Mean nutrient intakes by 7d WR and FFQ, and initial and repeat FFQ were similar and cross-classification showed few women to be grossly misclassified. Information was
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16

Johansson, Sara. "Vitamin A and Osteoporosis : Experimental and Clinical Studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4677.

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17

Snellman, Greta. "Boning up on Vitamin D : Observational Studies on Bone and Health." Doctoral thesis, Uppsala universitet, Ortopedi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159873.

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The primary function of vitamin D in humans is to maintain sufficient circulating calcium concentrations. Low vitamin D levels could result in excessive calcium resorption from bone. Vitamin deficiency may therefore decrease bone mineral density (BMD), resulting in an increased risk of fracture. This thesis sought to determine the association between vitamin D intake and bone health and to estimate circulating levels of vitamin D optimal for bone health without increasing the risk for non-bone disease. Furthermore, the thesis assessed the difference in performance between common serum vitamin
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18

Outila, Terhi. "The effect of vitamin D status on calcium and bone metabolism." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/maa/skemi/vk/outila/.

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19

Högström, Magnus. "Vitamins, fatty acids, physical activity and peak bone mass." Doctoral thesis, Umeå universitet, Kirurgisk och perioperativ vetenskap, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1451.

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Osteoporosis is a disease characterized by low bone mineral density, deteriorated bone microstructure and increased fracture risk. About 50% of all women and 25% of all men will have an osteoporotic fracture. Given that there is no effective cure in established osteoporosis, prevention is of high importance. Bone mineral density (BMD) is accumulated during childhood and adolescence with a peak at about 20 years of age. Peak BMD has been suggested to explain at least half of the variation in BMD up to old age. Thus, to increase peak BMD could decrease the risk of later fractures. The purpose of
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20

Romero, Rodney Gray. "The histology of bone and its piezoelectric characteristics." Thesis, Kingston University, 1986. http://eprints.kingston.ac.uk/20508/.

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An investigation into the effects of micro electric currents on the material of bone is presented along with a review of the ideas and concepts associated with bone’s response to load and the alleged piezoelectric phenomena. A comparison is made between the structure of bone, its strength and stress generated potential. Evidence is forwarded to show that micro currents may influence the behaviour of bone material and it is demonstrated that these effects may be understood through reference to the limiting molar conductivities of the ions in the material and the solutions used.
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21

Finch, Sarah L. "Postnatal vitamin D supplementation normalizes neonatal bone mass following maternal dietary vitamin D deficiency in the guinea pig." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100246.

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Since vitamin D deficiency is common at birth, the objective of this study was to test if postnatal vitamin D supplementation would normalize bone mineralization. Forty guinea pigs were randomized to receive a diet with or without vitamin D3 during pregnancy. Newborn pups were randomized to receive 10 IU of vitamin D3 or a placebo daily until d28. Measurements at birth and d28 included whole body and regional bone mass, osteocalcin and deoxypyridinoline, plus biomechanical testing of excised tibias and femurs. Offspring from deficient sows had lower body weight, whole body and tibia bone miner
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22

Ball, Lindsay Clare. "Cystic fibrosis and vitamin D supplementation." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2010m/ball.pdf.

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23

Allsopp, Richard Patrick. "The role of the vascular endothelium in bone formation." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386827.

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24

Orr, J. F. "Experimental measurement of stresses in bone and joint replacements." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373559.

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25

Dobson, Katharine Rebecca. "Studies into the effects of androgens on bone formation." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301007.

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26

El, Fakhri Nagla. "Effect of vitamin D supplementation on bone status, glucose homeostasis and immune function in children with vitamin D deficiency." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7555/.

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Background: Between 1961-1971 vitamin D deficiency was recognized as a public health issue in the UK, because of the lack of effective sunlight and the population mix [1, 2]. In recent years, health care professionals have cited evidence suggesting a re-emergence of the vitamin D deficiency linked to a number of health consequences as a concern [3-6]. Evidence from observational studies has linked low vitamin D status with impairment in glucose homeostasis and immune dysfunction [7-9]. However, interventional studies, particularly those focused on paediatric populations, have been limited and
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27

Drury, Donna. "Vitamin D and K status and bone health in pediatric cystic fibrosis patients." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101116.

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The objective of this study was to investigate the extent to which vitamin D and K are associated with bone health in pediatric cystic fibrosis (CF) patients. We hypothesized that: (1) the prevalence of vitamin D and K deficiencies would be high despite routine vitamin therapy, (2) bone health would be reduced and (3) vitamin K and D status would be associated with bone health.<br>Our results showed poor bone mineral mass in these CF children despite mild disease and good nutritional status. Neither vitamin K nor D was a predictor of bone health but weight and height Z-scores, fat-free mass, p
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28

Tomlinson, James M. "The Jocic reaction and the synthesis of Vitamin E." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/110296/.

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This thesis begins with an introduction to Vitamin E and the Jocic reaction. Chapter 1 provides a review of the biological activity of vitamin E and related compounds and the synthesis, both racemic and asymmetric, of vitamin E compounds. Also discussed in this chapter is the Jocic reaction and the synthesis of trichloromethyl alcohol compounds. Chapter 2 describes the asymmetric total syntheses of both α- and β-tocopherol, where an intramolecular Jocic reaction was used to provide a high enantiomeric excess. Difficulties encountered during the synthesis, and how these were overcome, are detai
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29

Kaovorakarn, Evelyn Amber. "The Effects of Vitamin C on Bone Development in Children and Adolescents." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579423.

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Background: Numerous studies have focused on the contribution of calcium and vitamin D to bone growth and mass accumulation, but not many focused on other nutrients such as vitamin for promoting bone growth and mineralization. Objectives: 1) To determine whether dietary intakes of Vitamin C positively supports bone growth and increases the bone mineral density in both boys and girls. 2) To determine the effectiveness of fruits and vegetables for improving bone mineral density in adolescents. Search Methods: The search strategies included a search on PubMed.gov for studies from year 2000 to pre
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30

Hamill, Matthew. "HIV, body composition, bone and vitamin D status in South African women." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/270410.

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Cross sectional and observational data suggest that HIV-positive individuals and those receiving antiretroviral (ARV) therapy are prone to higher rates of osteoporosis and osteopaenia than HIV-negative individuals. Likewise, HIV-positive individuals often have low vitamin D status. Evidence is emerging more generally of a strong association between HIV infection and poor bone health. There is also evidence that treatment with ARV therapy (ART) and suboptimal vitamin D status may exacerbate this problem (Brown et al, 2006a, 2010). But, to date, causal relationships have not been fully establish
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31

TOON, NICOLE MARIE. "INTAKES OF CALCIUM AND VITAMIN D AND THEIR RELATIONSHIP TO BONE HEALTH." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116019728.

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32

Avenell, Alison. "Nutritional influences on bone metabolism : three studies in postmenopausal women." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361777.

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Eleven postmenopausal women made weighed food intakes and urine collections for one week, to determine influences on urinary calcium and deoxypyridinoline excretion. Urinary calcium was influenced by both dietary calcium and dietary fibre. Urinary deoxypyridinoline was increased in women consuming more dietary fibre. The influence of ketosis was examined in five postmenopausal women, who increased urinary hydrogen ion excretion, but had no consistent changes in urinary calcium or deoxypyridinoline excretion. Forty-six postmenopausal women, with body mass index greater than 27kg/m<sup>2</sup>,
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33

Abel, Stefan. "The physiological effect of vitamin B12 deficiency in human blood." Thesis, Stellenbosch : Stellenbosch University, 1990. http://hdl.handle.net/10019.1/69031.

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Thesis (MSc) -- Stellenbosch University, 1990.<br>ENGLISH ABSTRACT: The main aim of this workpiece was to establish the physiological parameters against which a vitamin Bu deficiency could be measured. A comparison between the hematological values of healthy patients and those suffering from pernicious anemia due to vitamin Bu deficiency was done. A specific case of pernicious anemia was used in the comparison of abnormal values to the values of normal healthy patients. The comparison consisted of blood analyses with the help of specified instruments, photomicrographs of bone marrow and
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34

Campbell, Craig. "Bone health in children with cerebral palsy." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27231.

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Background. Children with cerebral palsy (CP) encounter a number of orthopedic complications as a result of abnormalities in motor function. One of the most significant complications is fragility fractures, occurring in up to 23% of children in prior reports. Despite a growing literature on how to best interpret bone densitometry in children, little research has determined optimal utilization of dual x-ray absorptiometry (DXA) in children with CP in order to characterize the patients' bone health status. This study outlines the use of the mechanostat theory of bone physiology to classify osteo
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35

McIntyre, Christopher William. "Studies into the effects of non-calcaemic vitamin D sterols on bone cells." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391629.

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36

Kanan, Raed Mohammad. "Molecular genetics and biochemistry of vitamin D binding proteins in metabolic bone disease." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287811.

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37

Lubczańska, Maria A. "The human vascular vitamin D hormonal system : expression and regulation." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58451/.

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Background: Patients suffering from chronic kidney disease (CKD) are at high risk of cardiovascular related premature death. In addition, traditional strategies for preventing cardiovascular disease (CVD) in patients with normal kidney function are less successful in patients with CKD. Vascular calcification (VC) and cardiac hypertrophy are common consequences. Recent evidence suggests that activation of the vitamin D receptor (VDR) is protective and is associated with significantly better survival in end stage renal disease (ESRD). Vascular smooth muscle cells (VSMCs) play a key role in the p
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38

Hoeger, Glenn Charles 1962. "Vitamin E turnover in cultured pulmonary alveolar macrophages." Thesis, The University of Arizona, 1992. http://hdl.handle.net/10150/278219.

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Vitamin E (α-TH), the primary lipid soluble antioxidant, can protect tissues from oxidative insult. Oxidant-producing pulmonary alveolar macrophages (PAM), may depend on α-TH to prevent oxidative damage. α-TH levels in cultured PAM declined rapidly during the first 12-18 hours in culture. Approximately 60% of the decrease was detected as unoxidized alpha-TH released to RPMI 1640 (containing 5% fetal bovine serum (FBS)) culture medium. α-TH was not detected in serum-free Ham's F12 medium. PAM appeared to reabsorb α-TH from the medium. PAM activation with phorbol myristate acetate (PMA) did not
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39

Westfall, Carola Hammer 1953. "Bone mineral content of femur, lumbar vertebrae, and radius in eumenorrheic female athletes." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276757.

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This study compared bone mineral index (BMI, gm/cm²) of the femur, spine, and radius, measured by photon absorptiometry in various groups of eumenorrheic female athletes. The sample included body builders (11), swimmers (13), runners (5 collegiate, 11 recreational), and inactive controls (18) averaging 25 years of age, ranging from 17 to 38 years. Lumbar vertebral BMI for body builders (1.40 gm/cm²) was significantly (p ≤ 0.05) greater than controls (1.25 gm/cm²). The body builders' femoral neck BMI (1.09 gm/cm²) was significantly greater than swimmers (0.97 gm/cm², recreational runners and co
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40

Ellis, Tiffany A. "Comparison of bone density in female vollyball players and age-matched non-athletes." Virtual Press, 2005. http://www.oregonpdf.org.

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41

Bawazeer, Nahla M. "Vitamin B12 and folate status during pregnancy among Saudi population." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/49940/.

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T2DM is a growing health problem worldwide. It is now increasingly being diagnosed earlier in life. The factors involved in such an epidemic are complex. The intrauterine environment has long been known as an important contributor to many diseases including metabolic disorders such as T2DM. Recently, there is emerging evidence for maternal micronutrients affecting vital developmental processes in utero which can adversely “programme” the offspring to develop metabolic disorders in later life. Thus, “gene-diet” interaction during foetal development is likely to be a significant contributor to t
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42

Khoja, Sawsan Omar. "Nutritional status of vitamin D and dietary intake of key bone health nutrients in Saudi Arabian women : implications for bone health." Thesis, University of Surrey, 2006. http://epubs.surrey.ac.uk/844240/.

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Osteoporosis is a common highly prevalence public health problem affecting both gender in all age stages in worldwide. Little information is known about the bone health and lifestyle characteristics of women living in Middle Eastern countries in general and Saudi Arabia in specific. The complete information and statistical figures of osteoporosis prevalent and vitamin D deficiency among population it has not yet been identified. The strong correlation between dietary intake and bone health has been explored in Western populations but no data are available in Middle Eastern countries. The aims
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43

Cardy, Susan Mary. "Lactobacillus leichmannii as a probe for the quantitation of vitamin B-12." Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/107025/.

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Initial attempts to isolate the gene encoding Vitamin B12 receptor protein (jbtuB) from Lactobacillus leichmannii, resulted in the isolation of the JbtuB gene from E. coli, due to either a cross-over or gene exchange event. Complementation of an E. coli JbtuB mutant was demonstrated and expression analysis, using both in vivo and in vitro systems, revealed the cloned gene to encode a polypeptide with an apparent Mr of 66,400 as determined by PAGE. Nucleotide sequence data confirmed that the cloned gene was identical to the JbtuB gene from E. coli. The initial 2.0 Kb Hindlll genomic DNA fragmen
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44

Zarei, Allahdad. "Comparison of the effects of vitamin D metabolites on osteoblast and osteocyte bone cells." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:8d363814-c1e5-4f16-929d-18ac9debde75.

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While the major source of vitamin D is D<sub>3</sub> from ultraviolet exposure, some supplements supply D<sub>2</sub>. The relative potency of vitamin D<sub>2</sub> versus vitamin D<sub>3</sub> remains controversial. The aims of the current study were, 1. To optimize the in vitro model, including use of cell lines, vitamin D concentrations, and outcome biomarkers. 2. To compare the potency of vitamin D<sub>2</sub> and D<sub>3</sub> metabolites on mouse and human bone cellular activity. 3. To explore the expression of VDR in osteoarthritic (OA) bone tissues as well as cellular responses to vita
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45

Willett, Alexis Maria. "Factors affecting vitamin D status in older adolescents and their relevance to bone health." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615157.

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46

Micklesfield, Lisa Kim. "Exercise and bone mass in mature premenopausal women." Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26979.

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47

Akter, Rahima. "Role of lamin A/C in the cellular features of age-related bone loss." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32525.

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Lamin A/C, an important component of the nuclear envelope, has been associated with cell differentiation and tissue development. In bone, recent studies have described that altered function of lamin A/C, due to mutations or incorrect processing, is associated with accelerated and severe bone loss. This could be due to alterations in the differentiation of mesenchymal stem cells (MSC) induced by lack of lamin A/C activity. Therefore, considering that decreased osteoblastogenesis and increased adipogenesis
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48

Young, Julia, and n/a. "Bone morphogenetic proteins are involved in controlling mammalian fertility." University of Otago. Department of Biochemistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20090112.122706.

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Transforming growth factor beta (TGFβ) superfamily members are involved in controlling mammalian fertility. The largest subset of the TGFβ superfamily are the bone morphogenetic proteins (BMP). BMP ligands signal through the type I and II BMP receptors and utilise the Smads1/5/8 phosphorylation cascade to control gene expression in the cell nucleus. Although BMPs act through the same pathway, they have the ability to activate unique sets of genes dependant on the identity of the ligand. In this study, HEK293T cells were challenged with BMP ligands for four hours and gene expression profiles we
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49

Gambari, Laura <1985&gt. "Hydrogen Sulfide (H2S) Based Therapeutics for Bone Diseases: Translating Physiology to Treatments." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7535/.

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Much progress has been made in the past decade in elucidating the physiological, pathophysiological and pharmacological role of Hydrogen Sulphide (H2S). Recently a function of H2S virtually in every tissue of the human organism has emerged. However, the H2S-mediated regulation of bone homeostasis has been scarcely investigated. Despite a recent increased interest in the field, many fundamental issues remain indeterminate. The main objective of this study was to increase the basic knowledge on the role of H2S in bone through in vitro and in vivo studies and develop novel therapeutic strategies
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50

Sutton, Amelia L. "The Regulation and Function of 1,25-Dihydroxyvitamin D3-Induced Genes in Osteoblasts." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1121820822.

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