Dissertations / Theses: 'Bone marrow – Transplantation'

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勞錦輝 and Kam-fai Simon Lo. "Cytomegalovirus and bone marrow transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31215609.

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Lo, Kam-fai Simon. "Cytomegalovirus and bone marrow transplantation /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19471142.

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3

Funaki, Hilde. "Psychological responses to bone-marrow-transplantation." Thesis, City University London, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283269.

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4

Davison, Glenda Mary. "Immune reconstitution post bone marrow transplantation." Master's thesis, University of Cape Town, 2000. http://hdl.handle.net/11427/3376.

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Bibliography: leaves 82-95.
The aims of this project were therefore: to document the immune reconstitution following T-cell depleted bone marrow and peripheral blood stem cell transplantation and to compare this with the recovery following autologous grafts. to document the cell surface expression of CD95 in an attempt to comment on the role played by FAS mediated apoptosis in the post transplant immune deficiency.

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Bågesund, Mats. "Salivary function after pediatric bone marrow transplantation /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4110-6/.

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6

袁國勇 and Kwok-yung Yuen. "Infectious complications in bone marrow transplant recipients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31981689.

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Mari, Elisabeth Rose. "Factors affecting the induction of transplantation tolerance in bone marrow transplantation." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9919.

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The engraftment of allogeneic haematopoietic stem cells (HSC) relies on the use partially or fully myeloablative regimens to condition the transplant recipient in order to “make space” in the bone marrow microenvironment and establish immunological tolerance to donor alloantigens. In murine models of bone marrow transplantation where donor-recipient pair differ for a single minor histocompatibility (H) antigen, HY, engraftment can be obtained using low-dose irradiation. Such conditioning favours the homeostatic expansion of regulatory (Treg) cells that play a crucial role in generating host versus graft tolerance (HvG). However, the HY model has some limitations because, in the clinical setting, HLA-matched donor and recipient still differ for several minor H antigens. Although there is evidence that immune responses across minor H differences concentrate on immunodominant epitopes, it was fundamental to understand whether increasing the number of donor antigenic disparities necessitated a proportional increment in the dose of conditioning to achieve engraftment. I utilised a bone marrow transplantation model in which donor and recipient differed for multiple minor H antigens and whereby immune responses were prominently skewed against a single immunodominant epitope. Recipient mice were C57BL/6 and bone marrow was obtained from BALB.B donors, whereby the immunodominant epitope was H60. My results showed that low-dose irradiation was not sufficient to obtained BALB.B donor cell engraftment but a fully myeloablative dose of (850cGy) was required. When the amount of antigenic determinants was decreased, by transplanting (BALB.BxC57BL/6) F1 cells, donor cell engraftment was achieved at an irradiation dose of 500cGy. These data show that the dose of conditioning regimen required for engraftment is proportional to the magnitude of the antigenic differences across donor and recipient. Different doses of myeloablation certainly bear different impacts on the depletion of lymphocyte subsets and lympho-haemopoietic reconstitution. Therefore, I investigated the kinetics and extent of Treg expansion. In all groups of transplanted mice the engrafted mice had significantly increased proportions of Treg cells which peaked during the second week post-transplant. When host Treg cells were depleted prior to transplantation with male C57BL/6 or (BALB.BxC57BL/6) F1 donor bone marrow under irradiated at 500cGy or 600cGy, the level of donor cell engraftment was not affected. However, there was a delay in the engraftment of (BALB.BxC57BL/6) F1 bone marrow, thus suggesting a marginal role for Treg cells using higher doses of conditioning. These data imply that the magnitude of antigenic disparities between the donor and recipient deeply impacts on the dose of irradiation required to obtain durable engraftment. The dose of irradiation does not correlate with the level of Treg cell expansion and Treg depletion only marginally affects engraftment. These data indicate that, in the presence of multiple antigenic disparities, depletion of T cell effecting HvG responses rather than induction of immune regulation is necessary.

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Bailey, Amy. "A systemic approach to paediatric bone marrow transplantation." Thesis, University of Birmingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408830.

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9

Gray, Caroline J. "Distress and emotional state throughout bone marrow transplantation." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/29729.

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Bone marrow Transplantation causes a variety of symptoms and emotional states which change throughout the treatment. The purpose of this descriptive correlational, repeated measures study was to describe the type and degree of symptom distress and the emotional states experienced by BMT patients at the time of admission, through the administration of chemotherapy and radiotherapy, bone marrow infusion, waiting for engraftment to 25 days following the infusion of bone marrow. In addition, this study investigated the relationship between symptom distress and emotional states of the BMT patient. The conceptual framework was based on Lazarus and Folkman's (1984) theory of stress, appraisal, and coping. The design involved administering McCorkle and Young's (1978) Symptom Distress Scale, McNair, Lorr, and Droppleman's (1971) Profile of Mood States, and two Data Collection Guides to ten patients at five times during the BMT procedure. A convenience sample of 12 subjects participated in the study. Overall, the participants experienced moderate degrees of symptom distress. Distress related to insomnia and appetite problems caused high levels of distress with moderate amounts of distress reported for distress related to nausea, pain, fatigue, bowel changes, concentration, and outlook. The least amount of distress was associated with appearance, breathing, and coughing problems. Symptom distress changed significantly over time with increased levels during the administration of chemotherapy and radiotherapy, one and seven days post-infusion and decreased to near baseline levels 25 days following the bone marrow infusion in all symptoms except outlook. Outlook distress was high initially and gradually declined over the course of the treatment. Significant changes were shown in nausea existence, appetite, insomnia, bowel, and concentration distress. The levels and changes seemed to reflect the clinical course of the BMT procedure. The participants showed moderate levels of emotional disturbance during the BMT with vigor and fatigue reaching high levels, tension and confusion reaching moderate levels, and depression and anger remaining fairly low. Emotional disturbance changed significantly over the course of the BMT for total emotional state and for all the emotional subscales except depression. The findings indicate that during times of intensive treatment emotional disturbance is greater. Total symptom distress and emotions showed no correlation except one day following bone marrow infusion; however, all six specific emotion components were correlated with at least one of the following distressful symptoms: outlook, pain, appearance, concentration, or fatigue. The findings suggest that symptom distress and emotions are closely linked to clinical events such as medications, blood transfusions, chemotherapy, radiotherapy, infections, nutritional deficits, but were tempered by coping abilities and lack of risk factors for emotional disturbance. Implications from the findings suggest specific times for the nurse to be particularly cognizant of specific symptom distress and emotional states and their patterns during the BMT. In addition, the nurse must be aware that there are complicated and uncomplicated courses for the BMT. The nurse must be adept at assessing the BMT patients for particular symptom distress and emotions when they are most likely to be problematic and to intervene appropriately.
Applied Science, Faculty of
Nursing, School of
Graduate

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Barron, Mary Anne. "Vitamin K deficiency in paediatric bone marrow transplantation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0008/MQ40822.pdf.

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Rodriguez, Francisco Jose. "Oral mucositis in children receiving bone marrow transplantation." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008m/rodriguez.pdf.

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Cavanagh, Gary. "The role of CD31 in bone marrow transplantation." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404955.

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Fegan, C. D. "The gut mucosal barrier following bone marrow transplantation." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308776.

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Langford-Smith, Kia Jane. "Non-myeloablative bone marrow transplantation for Mucopolysaccharide diseases." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nonmyeloablative-bone-marrow-transplantation-for-mucopolysaccharide-diseases(5d3fd9c5-01f2-42aa-81ed-a2ce6ef140fe).html.

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The Mucopolysaccharide (MPS) diseases are a group of lysosomal storage disorders, caused by a lack of the enzymes required for catabolism of glycosaminoglycans (GAGs), leading to severe neurological decline, skeletal deformities, organomegaly, cardiac and respiratory compromise, and premature death. The severe form of MPS I, Hurler syndrome, can be successfully treated using haematopoietic stem cell transplantation (HSCT), but the risks associated with myeloablation and immune suppression limit the broader application of HSCT to attenuated diseases. Successful engraftment in MPS I has been difficult to achieve, and requires fully myeloablative conditioning, whilst reduced intensity conditioning is a risk factor for graft rejection. Non-myeloablative conditioning generating reliable graft acceptance and high donor chimerism could increase safety and applicability of HSCT in genetic disease, therefore the aim of this research was to identify such a regimen in a clinically relevant mouse model of HSCT.Conditioning regimens developed in existing mouse models of HSCT have had limited clinical success, and often require clinically unachievable high cell doses or less stringent strain combinations to overcome allogeneic transplant rejection. To improve clinical relevance we used CBA donors and C57BL/6 recipients, which require full myeloablation with busulfan and immune suppression using non-depleting anti-CD4 and anti-CD8 monoclonal antibodies for engraftment of low cell doses across a major histocompatibility complex barrier. In syngeneic transplant donor chimerism was improved by generating a greater ratio of donor:recipient haematopoietic cells in the bone marrow initially, therefore we tested granulocyte colony stimulating factor (G-CSF), high cell dose and stem cell niche disruption and compared this to anti-CD40L costimulatory blockade in allogeneic transplant performed with a reduced dose of busulfan that was insufficient for graft acceptance. Despite improvements in initial engraftment with some of these treatments, only combined signal 1 and 2 T cell blockade were effective in reducing the dose of busulfan required for long-term graft acceptance. Early detection of MPS is important in treatment success; good disease biomarkers are vital, and biomarkers suitable for monitoring treatment outcome in MPS are lacking. We evaluated serum heparin cofactor II-thrombin (HCII-T) complex for MPS. We determined optimal sample collection and storage conditions, assay limitations and developed measurement in dried blood spots. Dermatan sulphate has a greater effect on in vivo HCII-T complex formation than heparan sulphate, thus in the MPS mouse models HCII-T is a reliable biomarker for MPS I, but not MPS IIIA or IIIB. HCII-T is greatly elevated in MPS I, II and VI patients, who all store dermatan sulphate, but it is also elevated by a small but significant amount in MPS III patients, who store heparan sulphate. HCII-T was also measured longitudinally in MPS I, II and VI patients, compared to an existing clinical biomarker, and validated against clinical outcomes to show that it is a good biomarker of short-term treatment outcomes and responds rapidly to perturbations in treatment. Finally, we determined whether an engraftment defect was observed in the MPS I mouse model, and show that this is present following both syngeneic and allogeneic HSCT. The effect of enzyme replacement therapy (ERT) and anti-inflammatory treatment prior to allogeneic HSCT was investigated, and initial results suggest that ERT, but not ibuprofen, may improve HSCT outcome. Overall, a clinically relevant mouse model of allogeneic HSCT has been developed and used to determine a non-myeloablative conditioning regimen that generates high levels of donor chimerism with a minimal dose of busulfan and blockade of both signal 1 and 2 of T cell activation. The conditions required to observe an engraftment defect in MPS I mice have also been defined, and preliminary studies have suggested that ERT, but not anti-inflammatory treatment, may overcome the engraftment defect in MPS I. Alongside this work, the HCII-T biomarker has been evaluated in MPS mouse models and patients, determining that it correlates well with short-term treatment outcomes. The techniques and models developed here will provide an excellent basis for further work in developing non-myeloablative conditioning for bone marrow transplant in MPS I.

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Jackson, G. H. "Long term bone marrow culture studies of patients with lymphoid malignancies undergoing autologous bone marrow transplantation." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309068.

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Ersek, Mary Therese. "The process of maintaining hope in adults with leukemia undergoing bone marrow transplantation /." Thesis, Connect to this title online; UW restricted, 1991. http://hdl.handle.net/1773/7202.

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17

Urbieta, Maitee. "Regulatory T Cells and Hematopoiesis in Bone Marrow Transplantation." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/463.

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CD4+CD25+FoxP3+ regulatory T cells (Treg) possess the capacity to modulate both adaptive and innate immunity. Due to their suppressive nature, Treg cells have been studied and tested in a variety of scenarios in an attempt to ameliorate undesired immune responses. While graft versus host disease (GVHD) has in fact emerged as the first clinical application for human Treg cells (Riley et al. 2009), equally important are issues concerning hematopoietic engraftment and immune reconstitution. Currently, little is known about the effect(s) that regulatory T cells may exert outside the immune system in this context. Based on cytokine effector molecules they can produce we hypothesized that Treg cells could regulate hematopoietic phenomena. The studies portrayed in this dissertation demonstrate that Treg cells can differentially affect the colony forming activity of myeloid and erythroid progenitor cells. In-vitro as well as in-vivo findings demonstrate the ability of Tregs to inhibit and augment the differentiation of primitive and intermediate myeloid (interleukin (IL)-3 driven) and late erythroid (erythropoietin driven) hematopoietic progenitor cells, respectively. The inhibitory and enhancing affects appeared to be mediated by independent pathways, the former requiring cell-cell contact, major histocompatibility complex (MHC) class II expression on marrow cells and involving transforming growth factor beta (TGF-beta), whereas the latter required interleukin (IL)-9 and was not contact dependent. Strikingly, we observed that in addition to regulating hematopoietic activity in normal primary BM cells, Tregs were also capable of suppressing colony forming activity by the myelogenous leukemia cell line NFS-60. Furthermore, studies involving endogenous Treg manipulations in-situ (i.e. depletion of these cells) resulted in elevated overall myeloid colony activity (CFU-IL3) and diminished colony numbers of erythroid precursors (CFU-E) in recipients following BMT. Consistent with these results, it was found that upon co-transplant with limiting numbers of bone marrow cells, exogenously added Treg cells exert in-vivo regulation of myeloid and erythroid CFU activity during the initial weeks post-transplantation. This regulation of hematopoietic activity by freshly generated Tregs upon transplantation led to the elaboration of a second hypothesis; following lethal total body irradiation (TBI) the host microenvironment facilitates regulatory T cell activation/effector function. Substantial evidence has accumulated in support of this hypothesis, for example we demonstrate up-regulation of surface molecules such as GARP and CD150/SLAM, which have been previously reported as indicators of Treg activation following TCR signaling and co-stimulation, occurs in donor (reporter) Treg populations. Acquisition of an activated phenotype and hence of effector/modulatory function is consistent with the previous in-vivo observations, indicating that both recipient and donor Treg cells can influence hematopoietic progenitor cell activity post-transplant. Finally, the present studies may be of great relevance in the emerging field of Treg cell based immunotherapy for prevention and/or treatment of HSCT complications.

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18

Frisk, Per. "Late Effects After Autologous Bone Marrow Transplantation in Childhood." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3673.

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Taveroff, Arlene. "Metabolic derangements following bone marrow transplantation : an integrated analysis." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74259.

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Bone marrow transplantation (BMT) involves the use of maximal doses of chemotherapy and total body irradiation. As a result, even well-nourished patients exhibit negative nitrogen balance and hypoproteinemia in the post-transplant period, despite a high energy and protein intake from Total Parenteral Nutrition (TPN). The purpose of this research was to investigate the impact of cytotoxic therapy, with a view toward explaining and improving the response to nutritional support. Stool, urine and serum biochemistry were studied prospectively in 10 BMT patients. Analysis of stool revealed increased sodium and decreased potassium. Examination of serum electrolytes indicated hyponatremia and hyperkalemia. A significant decrease in nitrogen balance, serum albumin and net protein utilization immediately followed the disturbances in serum electrolytes; improvement began as serum sodium and potassium returned to normal. Thus, electrolyte imbalance may have reduced the capacity of cells to utilize nitrogen. Lowering the volume of TPN dramatically decreased serum electrolyte aberrations and improved nitrogen utilization.

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Eltumi, Muftah. "Connective tissue metabolites following bone marrow transplantation in children." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309105.

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Hudson, John G. "The application of ultraviolet light to bone marrow transplantation." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296599.

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Peters, Paula Ann 1959. "Navigating survival: Quality of life following bone marrow transplantation." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/291910.

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This study explored the quality of life of adult Bone Marrow Transplantation (BMT) survivors and processes involved in maintaining or enhancing life quality were identified. Grounded theory methodology was used to explore quality of life from the survivor's perspective. Five adults, 87 to 578 days post BMT, were selected using theoretical sampling and interviewed. A theory of Navigating Survival emerged from data analysis as a series of coping processes employed by BMT survivors to manage quality of life disruptions. BMT survivors identified disruptions in quality of life during the rapid decision-making period; after discharge when limitations on physical activity must be managed; and as activities resume but fears of recurrence became stronger. Coping mechanisms used varied but were directed toward three areas: adapting to transplant, searching for meaning, and discovering a difference. Identifying unique quality of life aspects will enable oncology nurses to design interventions to enhance life quality of BMT survivors.

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呂景希 and King-hei Crosby Lu. "A single centre, randomised trial on harvest cell yield and marrow engraftment using haemopoietic growth-factor primed bone marrow." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970746.

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Remberger, Mats. "Cytokine production in allogeneic haematopoietic stem-cell transplantation patients /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3749-4/.

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李玉嫻 and Yuk-han Li. "Telomere length variation and lineage chimerism in bone marrow transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31227594.

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Sage, Deborah Anne. "HLA-DP immunogenetics and significance in allogeneic bone marrow transplantation." Thesis, University of Portsmouth, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308955.

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Ogita, Hideaki. "Transplantation of bone marrow-derived neurospheres into guinea pig cochlea." Kyoto University, 2010. http://hdl.handle.net/2433/120598.

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Näsman, Björk Ingrid. "Reconstitution of the B-cell repertoire following allogeneic bone marrow transplantation /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3807-5/.

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Lin, Feng. "Minimal residual disease after bone marrow transplantation for chronic myeloid leukaemia." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285196.

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Hunnisett, Adrian G. W. "Micronutrient interaction in the management of patients following bone marrow transplantation." Thesis, Oxford Brookes University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318301.

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Sviland, Lisbet. "Histology and immunopathology of skin and rectum following bone marrow transplantation." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235533.

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32

Mc, Kenzie Lena. "Psychosocial factors that influence sibling donors during allogeneic bone marrow transplantation." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80264.

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Thesis (MCurr)--Stellenbosch University, 2013.
ENGLISH ABSTRACT: Haematopoietic stem cell transplantation has become an increasingly popular treatment option for persons with life-threatening blood related diseases such as leukemia, lymphoma, myeloma and certain forms of anaemia. Due to this new therapy the use of bone marrow from a healthy individual also called a living donor for transplantation is inevitable. These living donors can experience psychological and economic issues and these components needs to be addressed in the transplant protocol. The researcher described the psychosocial factors that influenced sibling donors during allogeneic bone marrow transplantation at a public sector hospital in Cape Town, whether the transplant team members explained the administrative process of the transplant in an understandable manner and language and the effect of the psychosocial factors and administrative process of the allogeneic bone marrow transplantation on the sibling donors. A quantitative research approach with a descriptive design was used in this study. The sample was selected by means of full population sampling. The final sample size of (n=64) stem cell sibling donors over 18 years of age participated in the study. A self-reporting questionnaire was used to gather data, inclusive of four open-ended questions to establish an in depth sense of what the donor experiences during the bone marrow donation process. Descriptive statistics used to describe the variables included frequency distributions in the form of histograms and frequency tables. The Pearson chi-square statistical analysis test was used to test for relationships amongst groups. The study drew on the Roy Adaptation Model (RAM) as the theoretical framework to explain the phenomena surrounding the psychosocial and administrative effect of the transplantation process on the sibling donor. Based on the findings the haematopoietic stem cell donors coped with the psychosocial impact of the donation process by making use of their coping mechanism to adapt to their situation according to the Roy Adaptation Model. This model also offers guidance to the nurses to apply this model to nursing practice. Results revealed that sibling donors developed feelings of anxiety in relation to the invasive procedures that cause them to experience physical pain. Most respondents claimed that they were not psychologically affected by the donation process. The moral obligation the sibling donor has towards his sister or brother outweighed the physical pain or discomfort experienced during the donation process. Results revealed that the responding donors claimed they were well informed regarding the donation process and understood the treatment plan of the recipient. However, results revealed that there was a lack in visual donor information such as books, pamphlets as well as internet information. Results concerning the demographics revealed that (n=29) respondents had no schooling and some respondents had some schooling which can give an indication of how to bridge the knowledge and information gap between them and the donor in terms of language. Statistical significance results regarding the emotional state and economic situation of the donors was found. Some of the respondents were responsible for their own transport and their own accommodation, some of those that are employed were responsible for leave without pay. An organ donation policy needs to be developed to prevent live organ donors from losing valuable working hours that could result in loss of salary and should provide other financial incentives. Furthermore, a lack in a post-donation follow-up medical to alleviate and detect post-donation complications was identified. Further nursing research can help nurses to understand living donation for transplantation, also how the nurses that practice in organ transplant units experience and deal with the psychosocial factors that influence them particularly.
AFRIKAANSE OPSOMMING: Hematopoïetiese stamseloorplanting het ’n toenemend gewilde-behandelingsopsie vir persone met lewensgevaarlike bloedverwante siektes soos leukemie, limfoom, miëloom en sekere soorte anemie geword. Vir hierdie tipe terapie word die beenmurg van ’n gesonde individu, ook bekend as ’n lewende skenker, vir oorplanting gebruik. Lewende skenkers kan sielkundige en ekonomiese probleme ervaar en hierdie kwessies moet in die oorplantingsprotokol hanteer word. In hierdie studie is ondersoek ingestel na die psigososiale faktore wat bloedverwante skenkers tydens allogeneïese beenmurgoorplanting by ’n openbare hospitaal in Kaapstad beïnvloed, of die oorplantingspan die administratiewe proses van die oorplanting op ’n verstaanbare manier en in verstaanbare taal verduidelik het, en wat die uitwerking wat die psigososiale faktore en administratiewe proses is op die bloedverwante skenkers tydens allogeneïese beenmurgoorplanting. ’n Kwantitatiewe benadering met ’n beskrywende navorsingsontwerp is in hierdie studie gebruik. Die steekproef is op grond van volledige populasiesteekproefneming gekies. ’n Finale steekproefgrootte van stamselskenkers (n=64) ouer as 18 jaar het aan die navorsing deelgeneem. ’n Selfverslaggewende vraelys is gebruik om data in te samel, wat vier oop vrae ingesluit het om grondige begrip te verkry van wat die skenker tydens die beenmurgskenkingsproses ervaar. Beskrywende statistiek wat gebruik is om die veranderlikes te beskryf, sluit in frekwensie-verspreidings in die vorm van histogramme en frekwensie-tabelle. Die Pearson chi-kwadraat- statistieseanalise is gebruik om die verwantskappe onder groepe te toets. Die Roy Adaptation Model (RAM) is as die teoretiese raamwerk vir die studie gebruik om die verskynsels betrokke by die psigososiale en administratiewe ervaring van die oorplantingsproses vir die bloedverwante skenker te verklaar. Op grond van die bevindinge het die hematopoïetiese stamselskenkers die psigososiale impak van die skenkingsproses hanteer deur gebruik te maak van hulle hanteringsmeganisme om by hulle situasie aan te pas, wat met die RAM ooreenstem. Hierdie model bied ook leiding aan verpleegkundiges om dit in die verplegingspraktyk toe te pas. Resultate het getoon dat bloedverwante skenkers gevoelens van angs ontwikkel het vanweë die indringende prosedures, wat fisiese pyn veroorsaak het. Die meeste deelnemers het aangedui dat hulle nie sielkundig deur die skenkingsproses geraak is nie. Die morele verpligting wat die bloedverwante skenker het teenoor sy of haar broer of suster het die fisiese pyn of ongemak gedurende die skenkingsproses oortref. Resultate het getoon dat die deelnemende skenkers aangedui het dat hulle goed ingelig was oor die skenkingsproses en die behandelingsplan van die ontvanger verstaan het. Die resultate dui egter daarop dat daar ’n gebrek was aan visuele skenkersinligting soos boeke, pamflette en internet-inligting. Resultate rakende die demografie het bewys dat van die deelnemers (n=29) ongeskoold en sommige deelnemers laag geskoold is, wat ’n aanduiding kan gee van hoe die kennis- en inligtingsgaping tussen hulle en die skenker ten opsigte van taal oorbrug kan word. Statisties beduidende resultate rakende die emosionele toestand en ekonomiese situasie van die skenkers is gevind. Sommige deelnemers was verantwoordelik vir hulle eie vervoer en verblyf. Diegene wat werk, het verlof sonder betaling geneem. ’n Orgaanskenkingsbeleid moet ontwikkel word om te verhoed dat lewende orgaanskenkers kosbare werksure verloor, wat kan lei tot ’n verlies aan salaris. Ander finansiële aansporings behoort ook gegee te word. Voorts is ’n gebrek aan opvolg mediese behandeling vir skenkers om skenkingskomplikasies vas te stel en te verlig, geïdentifiseer. Voortgesette navorsing kan verpleegkundiges help om begrip te verkry van die implikasies van lewende orgaanskenking. Verpleegkundiges wat in hierdie orgaanoorplantings- eenhede werksaam is, kan ‘n beter begrip kry van die psigososiale faktore wat hierdie skenkers spesifiek beïnvloed.

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33

Nicol, Andrew. "Analysis and in-vitro expansion of cord blood haemopoietic stem cells for transplantation." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337265.

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34

Deng, Jie. "Neurogenesis of adult stem cells from the liver and bone marrow." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009700.

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Thesis (Ph.D.)--University of Florida, 2005.
Typescript. Title from title page of source document. Document formatted into pages; contains 143 pages. Includes Vita. Includes bibliographical references.

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O'Brien, Stephen Gerard. "Haemopoietic stem cell purging in chronic myeloid leukaemia." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300928.

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Dezenhall, Amy. "Food and nutrition services in bone marrow transplant centers." FIU Digital Commons, 1985. http://digitalcommons.fiu.edu/etd/2790.

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Nutritional support for bone marrow transplant recipients is recognized as vital, yet little research has occured to determine the best method. This study was designed to survey existing food and nutrition services in bone marrow transplant centers in the U.S. in order to determine similarities in the services provided among centers from which a model protocol could be established for such centers. A survey instrument was developed and sent to all chief dietitians associated with BMT centers in the U.S, listed the International Bone Marrow registry, 1982. Items on the questionnaire included: background information on size and organization, nature of foodservice, and nutrition support services. The research suggested that there was a trend away from sterile food service. Problems encountered in establishing the food and nutrition services included: availability of single-serve sterile foods, standardization of recipes, and palatability of autoclaved foods. Four centers switched from sterile diets to either low bacteria diets or modified house diets at some point in their operation. Patient related services of the registered dietitian were most concentrated on admission and during critical care monitoring. Near all respondents indicated a desire to form a network for developing standards for services provided. Many differences between centers still remain which prevent the development of a model center.

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Wimperis, J. Z. "Immune reconstitution in humans following allogenic T-lymphocite-depleted bone marrow transplantation." Thesis, University of Oxford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233560.

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Barge, Dawn. "T cell reconstitution post bone marrow transplantation in children with primary immunodeficiencies." Thesis, Northumbria University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397830.

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Mohini, Rajasagi. "Allogeneic Bone Marrow Transplantation and Role of CD44 in T cell Maturation." [S.l. : s.n.], 2008. http://digbib.ubka.uni-karlsruhe.de/volltexte/1000010091.

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Lee, Jia-Hui Jane. "Effect of donor KIR Genotype on the outcome of bone marrow transplantation." Thesis, Lee, Jia-Hui Jane (2013) Effect of donor KIR Genotype on the outcome of bone marrow transplantation. Honours thesis, Murdoch University, 2013. https://researchrepository.murdoch.edu.au/id/eprint/16228/.

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Haematopoietic stem cell transplantation is the only curative treatment for some forms of haematologcial malignancies and bone marrow failure. The role of donor Natural Killer (NK) cells that accompany the donor stem cells is under investigation. In particular, there is interest in the role of the killer immunoglobulin-like receptors (KIR) family of receptors expressed on the surface receptors of NK cells. In this study, we focused on the donor KIR genes and the possibility that the KIR receptors interact with other transplant variables to influence survival. We analyzed a cohort of 140 unrelated donors from bone marrow transplants carried out at Royal Perth Hospital and Princess Margaret Hospital. The variables that were analyzed for interactions with KIR were: cytomegalovirus (CMV) status, transplant graft source, conditioning agents. A number of significant interactions between KIR and transplant variables were identified, the strongest being the interaction between KIR2DS2 and the use of cyclophosphamide as a conditioning agent. Kaplan-Meier analyses showed that the presence of KIR2DS2 in a cyclophosphamide positive transplant resulted in a significantly improved survival (p=0.002) whereas the presence of KIR2DS2 in a cyclophosphamide negative transplant resulted in a poorer survival (p=0.032). Hence the presence of KIR2DS2 could be beneficial or deleterious depending on the presence or absence of cyclophosphamide. As this was an exploratory study, observations of the interactions discovered need to be confirmed in additional studies.

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Cartwright, Nicola Helen. "Cytokine profiles and their relevance to human transplantation." Thesis, University of Plymouth, 1999. http://hdl.handle.net/10026.1/2604.

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The aim of this project was to develop an in vitro functional assay for the prediction of allograft rejection following renal transplantation. This assay was also used to study acute GVHD following identical sibling bone marrow transplantation. Lymphocyte cytokine profiles were measured by ELISA (protein secretion) and flow cytometry (cytokine expression) following mitogen stimulation and MLR. In normal individuals, considerable inter-individual variations were found in both protein secretion (IL-2, IL- 4, IL-10 and IFN-γ) and cytokine expression (IL-2 and IFN-γ). Strong relationships were found between IL-2 protein and expression, IL-2 and IL-10 protein, and IL-10 and IFN-γ protein secretion. Analysis of cytokine gene polymorphisms showed no correlation between IFN-y protein secretion, frequency or gene polymorphism. Pre-transplant MLRs were set up between renal transplant patient/donors pairs and cytokine protein secretion (IL-2, IL-4, IL-6, IL-10 and IFN-γ) measured by ELISA. Analysis was performed to ascertain predictive factors of allograft rejection. Inter-individual variations were found for all cytokine profiles. Significant correlations were found between individual cytokine protein profiles including IL-10 and IFN-γ. In addition, a correlation was found between HLA-DR mismatching and both IL-10 and IFN-γ protein secreted in the MLR. Primary univariate analysis revealed that HLA and HLA-DR mismatching, female donor sex, MLR-stimulated IL-10, MLR-stimulated IFN-γ and spontaneous IL-4 secretion were associated with an increased risk of rejection. Multivariate analysis showed the strongest correlations for predicting risk of rejection to be female donor sex, HLA mismatching and MLR-stimulated IL-l 0 secretion. A combination of high HLA mismatching and high IL-l 0 secretion in MLR gave the highest risk of rejection (RR=25.5). Finally, cytokine secretion decreased when measured post-transplant. Prediction of graft survival could not be analysed due to the low number (n=6) of patients that suffered graft failure in the group. Cytokine protein secretion (IL-2, IL-4, IL-10 and IFN-γ) in MLR was also studied for prediction of GVHD after bone marrow transplantation. There was a very low MLR response by all BMT pairs, therefore analysis could not be performed.

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Wang, Xiao Nong. "Quantitative analysis of alloreactive T cells in allogeneic stem cell transplantation." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362419.

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Steeves, Richard H. "The experiences of suffering and meaning in bone marrow transplant patients /." Thesis, Connect to this title online; UW restricted, 1988. http://hdl.handle.net/1773/7242.

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Yoshikawa, Tetsushi. "Human herpesvirus 6 iInfection in transplantation." Nagoya University School of Medicine, 2001. http://hdl.handle.net/2237/5363.

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Spath, Mary L. "The impact of family functioning on children's adaptation during a parent's bone marrow transplantation." Thesis, Connect to resource online, 2010. http://hdl.handle.net/1805/2122.

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Thesis (Ph.D.)--Indiana University, 2010.
Title from screen (viewed on April 8, 2010). School of Nursing, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Betsy L. Fife, Joan K. Austin, Patrick O. Monahan, Silvia M. Bigatti, Linda G. Bell. Includes vitae. Includes bibliographical references (leaves 233-248).

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46

Bogdanovic, Gordana. "Studies on human polyomavirus infection in association with central nervous system disorders and bone marrow transplantation /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980612bogd.

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47

Lim, Seah-Hooi. "Immunotherapy and recombinant interleukin-2 in acute myeloid leukaemia." Thesis, University of Aberdeen, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484307.

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In this study 12 acute myeloid leukaemia (AML) patients (3 in 1^st complete remission (CR), 3 in 2^nd CR, 3 in early relapse or partial remission and 3 in frank relapse) were treated with continuous infusion of recombinant Interleukin-2 (rIL-2). Adverse reactions among these patients were common. In all patients, there were evidence of lymphocyte activation with subsequent upregulation of the cellular cytotoxic functions following the infusion of rIL-2. Despite this, clinical response among patients treated with active disease remains disappointing, with only 1 patient achieving a 3^rd complete remission after being treated in early 2^nd relapse (marrow blast counts of 10%). The other patients had brief periods of stable disease but died eventually of disease progression. No conclusion however can be drawn from patients treated in complete remission due to the small number of patients entered into the study. In vitro studies were performed in a different cohort of AML patients, at presentation and during complete remission. In all the patients, both the Natural Killer (NK) and Lectin-Dependent Cellular Cytotoxicity (LDCC) activities were significantly reduced when compared to normal healthy controls. Patients in complete remission however had higher values than those studied during active diseases. These findings would suggest a strong rationale for the use of immunotherapy capable of upregulating the NK and LDCC activities, e.g. rIL-2. Further rationale for the use of immunotherapy has been drawn from the findings that leukaemia blast cells of AML are immunogenic, as evidenced by data of T cell activation in these patients and the presence of complement-fixing antibodies for autologous myeloblasts. More importantly no stimulation of the myeloblast proliferation by IL-2 was observed in any of the myeloblasts studied. All these findings would point to a good and safe rationale for the use of rIL-2 in AML patients.

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Holyoake, Tessa Laurie. "Investigation of the effects of in vitro cytokine exposure on short and long term reconstituting haemopoietic stem and progenitor cells in a murine model." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320310.

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Tse, Hung-fat, and 謝鴻發. "Bone marrow cell transplantation for therapeutic angiogenesis in ischemic myocardium: from bench to bedside." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557972.

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Wong, Wilson. "Tolerance to allografts using recipient bone marrow cells trandsduced with a donor MHC gene." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389040.

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Dissertations / Theses on the topic 'Bone marrow – Transplantation'

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