Relevant bibliographies by topics / Bone marrow lesions

Academic literature on the topic 'Bone marrow lesions'

Author: Grafiati
Published: 10 December 2022
Last updated: 20 February 2023

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Journal articles on the topic "Bone marrow lesions"

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Belurkar, Sushma, Anna Joseph Amprayil, and Chethan Manohar. "Clinicopathologic Study of Granulomatous Lesions in the Bone Marrow." Indian Journal of Forensic Medicine and Pathology 11, no. 3 (2018): 192–201. http://dx.doi.org/10.21088/ijfmp.0974.3383.11318.8.

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Erik Jensen, Karl. "DETECTION OF BONE MARROW LESIONS." Lancet 333, no. 8642 (April 1989): 843–44. http://dx.doi.org/10.1016/s0140-6736(89)92299-x.

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Björkman, Ann-Sofi, Seppo K. Koskinen, Maria Lindblom, and Anders Persson. "Diagnostic accuracy of dual-energy CT for detection of bone marrow lesions in the subacutely injured knee with MRI as reference method." Acta Radiologica 61, no. 6 (October 3, 2019): 749–59. http://dx.doi.org/10.1177/0284185119877343.

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Background Dual-energy computer tomography (DECT) can detect post-traumatic bone marrow lesions. Prospective studies of the knee with large numbers of participants and intra-observer agreement assessment are limited. Purpose To investigate the diagnostic accuracy of DECT in detecting bone marrow lesions as well as estimating the bone marrow lesion volume in patients with suspected anterior cruciate ligament trauma with magnetic resonance imaging (MRI) as reference standard. Material and Methods Forty-eight consecutive patients with suspected anterior cruciate ligament injury were imaged bilaterally with DECT within a mean of 25 days (range 4–55 days) following injury and MRI within seven days of DECT. Two readers analyzed DECT virtual non-calcium-blinded images. Consensus MRI was reference standard. Intra- and inter-observer agreement were determined using weighted kappa statistics. Sensitivity, specificity, and negative and positive predictive values were calculated. Bone marrow lesion volumes were measured; for comparison, intra-class correlation coefficient was used. Results The 48 patients (26 men, 22 women; mean age 23 years, age range 15–37 years) were imaged bilaterally yielding 52 knees with bone marrow lesions, of which 44 were in the femur and 41 were in the tibia. Intra- and inter-observer agreement to detect bone marrow lesions was moderate and fair to moderate (κ 0.54–0.66, 95% confidence interval [CI] 0.39–0.80 and 0.37–0.41, 95% CI 0.20–0.57) and overall sensitivity and specificity were 70.1% and 69.1%, respectively. Positive and negative predictive values were 72.9% and 66.1%, respectively. Bone marrow lesion volumes showed excellent intra- and inter-observer agreement (0.83–0.91, 95% CI 0.74–0.94 and 0.76–0.78, 95% CI 0.57–0.87). Conclusion The diagnostic performance of DECT to detect bone marrow lesions in the subacutely injured knee was moderate with intra- and inter-observer agreement ranging from moderate to substantial and fair to moderate. Bone marrow lesion volume correlation was excellent.
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Lutsik, N. S., L. P. Mendeleeva, and G. A. Yatsik. "Informative value of whole-body magnetic resonance imaging with diffusion-weighted images for the detection of bone marrow infiltration in patients with multiple myeloma (literature review)." Oncohematology 17, no. 1 (January 29, 2022): 87–94. http://dx.doi.org/10.17650/1818-8346-2022-17-1-87-94.

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Magnetic resonance imaging (MRI) is increasingly being used to diagnose bone marrow lesions in patients with multiple myeloma (MM). Since 2014, the results of MRI have been included in the updated criteria of the International Myeloma Working Group. The presence of >1 bone marrow lesion larger than or equal to 5 mm on MRI is considered sufficient for the diagnosis of symptomatic MM, requiring initiation of treatment. MRI assessment of bone marrow is also possible with functional sequences such as diffusion-weighted imaging (DWI), which provide additional information about the bone marrow. This article provides an overview of the possibilities of MRI with anatomical sequences and with DWI for diagnosing, monitoring and evaluating the response to treatment in patients with MM. In patients with monoclonal gammopathy of undetermined significance and smoldering myeloma, in some cases, pathological changes in the bone marrow can be detected by MRI. The presence of >1 bone marrow lesion on MRI is a cut-off value as a prognostic factor for the progression of monoclonal gammopathy of undetermined significance or smoldering myeloma to symptomatic MM. In symptomatic MM, there are four patterns of bone marrow infiltration on MRI – focal, diffuse, “salt-and-pepper” infiltration, and combined diffuse and focal pattern, which have prognostic significance. Patients with diffuse pattern of infiltration on MRI had a 3-year overall survival of 35 % versus 92 % in patients with normal MRI bone marrow. During treatment of MM patients, residual bone marrow lesions are often identified on MRI. MRI residual bone marrow lesions increase the risk of MM relapse. In the group of patients who had residual bone marrow lesions on MRI on the 100th day after autologous hematopoietic stem cell transplant, 2-year progression-free survival was 50 % versus 89 % in patients without bone marrow lesions at the same time. The addition of DWI to the scan protocol helps to differentiate persistent focal bone marrow lesions that can lead to MM relapse after the treatment phase. Apparent diffusion coefficient is a quantitative indicator of DWI. MRI can serve as a valuable tool for assessing the treatment response in patients with MM.
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Nazinkina, Yu V. "BONE MARROW LESIONS: DIAGNOSIS WITHOUT BIOPSY." Diagnostic radiology and radiotherapy, no. 1 (April 9, 2019): 19–25. http://dx.doi.org/10.22328/2079-5343-2019-10-1-19-25.

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Routine spinal MRI can be used for bone marrow lesions detection. The most useful standard pulse sequence is T1- WI, which helps both in local and diffuse bone marrow diseases. Additional new pulse sequences, including chemical shift imaging and diffusion weighted imaging, can be used as solving-problem techniques.
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Sharkey, Peter, and Steven Cohen. "Subchondroplasty for Treating Bone Marrow Lesions." Journal of Knee Surgery 29, no. 07 (December 7, 2015): 555–63. http://dx.doi.org/10.1055/s-0035-1568988.

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Chang, Karen L., Karl K. Gaal, Qin Huang, and Lawrence M. Weiss. "Histiocytic lesions involving the bone marrow." Seminars in Diagnostic Pathology 20, no. 3 (August 2003): 226–36. http://dx.doi.org/10.1016/s0740-2570(03)00030-3.

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ZOLER, MITCHEL L. "Zoledronic Acid Shrank Bone Marrow Lesions." Family Practice News 41, no. 11 (June 2011): 17. http://dx.doi.org/10.1016/s0300-7073(11)70583-7.

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ZOLER, MITCHEL L. "Zoledronic Acid Shrinks Bone Marrow Lesions." Internal Medicine News 44, no. 12 (July 2011): 24–25. http://dx.doi.org/10.1016/s1097-8690(11)70601-1.

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Hyun, Bong Hak. "Plasmacytic lesions of the bone marrow." International Journal of Hematology 76, S2 (March 2002): 11. http://dx.doi.org/10.1007/bf03165079.

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Dissertations / Theses on the topic "Bone marrow lesions"

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Kuttapitiya, Anasuya. "Investigating the role of bone marrow lesions in osteoathritic pain." Thesis, St George's, University of London, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753987.

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Bone marrow lesions (BML) are well described in osteoarthritis (OA) using magnetic resonance imaging (MRI) and are associated with pain, however little is known about their pathological characteristics and gene expression. This study evaluated BMLs using tissue analysis tools to gain a deeper understanding of how they mediate pain. A total of 117 participants were recruited, 74 with advanced OA requiring total knee replacement (TKR), 23 with mild OA, 7 healthy controls and 13 non-OA tissue comparator controls. A multidimensional approach was taken to investigate how clinical, radiological and molecular changes in OA knee joints correlate with pain perception. Pain scoring (Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Pain DETECT) and quantitative sensory testing (QST) were used to characterise the pain experienced by participant. To assess structural changes MR images were scored using MRI Osteoarthritis Knee Score (MOAKS) by two independent scorers. The MRI scans were used to localise BMLs for whole transcriptomic analysis, qPCR for array validation, histological evaluation, scanning electron microscopy and quantitative protein expression. Serum samples obtained at baseline visits were used for biomarker investigation. The result demonstrates that BMLs are regions of increased cellular and metabolic activity and correlated with increased pain and sensitisation. The findings contribute to the understanding of OA pathogenesis and could help lead to the development of new diagnostic tools and future therapies for the improved management of this increasingly prevalent condition.
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AlAbbad, Hani. "The Effects of Extracorporeal Shockwave Therapy on Knee Osteoarthritis Related Bone Marrow Lesions." Thesis, Curtin University, 2022. http://hdl.handle.net/20.500.11937/89769.

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This thesis presents the findings from three studies that examined the clinical and biological effects of Focused-Extracorporeal Shockwave Therapy (ESWT) on knee osteoarthritis (OA) related bone marrow lesions (BML). Previous research has indicated that ESWT can influence the underlying pathophysiological process of musculoskeletal disorders. This research showed that focused-ESWT is safe and has a dose-dependent effect on clinical outcomes in knee OA-related BMLs. However, the effects on underlying pathophysiological mechanisms were not conclusive.
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Camelli, Alberto. "Il ruolo del Fisioterapista nella gestione e nel trattamento conservativo dell’edema osseo. Scoping review." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24558/.

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Background L’edema osseo è una condizione riscontrata con la Risonanza Magnetica Nucleare in associazione a patologie di origine meccanica, infiammatoria e reumatologica. Caratterizzato da un’alterazione del segnale dovuta ad un aumentato contenuto d’acqua nella midollare ossea, l’edema osseo è spesso associato a dolore, impotenza funzionale e accelerazione dei processi degenerativi articolari. Considerata la rilevanza clinica e la probabile correlazione tra BME ed Osteonecrosi, emerge la necessità di identificare opzioni di trattamento efficaci al fine di ridurre la sintomatologia ed evitare l’evoluzione di tale lesione. Obiettivo L’obiettivo di questa Scoping Review è quello di identificare gli interventi fisioterapici di maggior efficacia nel trattamento di BML e BMES ponendo come misure di outcome il miglioramento della funzione, la riduzione del dolore e della dimensione dell’edema osseo in RMN. Metodi Nel periodo aprile-agosto 2021 sono state esplorate le seguenti banche dati: PubMed, Cochrane Library e PEDro. Sono stati selezionati 5 studi che indagavano interventi conservativi del BME coerenti con outcome clinici e radiologici presenti nel quesito di ricerca. Risultati Gli studi mostrano miglioramenti statisticamente significativi negli outcome indagati grazie all’utilizzo di Magnetoterapia, onde d’urto e camera iperbarica nel trattamento di soggetti con BME. Gli studi che indagano l’efficacia degli ultrasuoni e della limitazione del carico sull’arto affetto non mostrano differenze statisticamente significative tra i gruppi di trattamento e controllo. Conclusioni In soggetti con BME, l’intervento mediante Magnetoterapia, Onde d’urto o Camera iperbarica, sembra migliorare l’evoluzione della lesione nei tre outcomes indagati. Gli ultrasuoni e l’utilizzo di un bastone sembrano invece non favorire la guarigione del BME. Sono necessari studi di maggior qualità che valutino l’efficacia dei trattamenti analizzati proponendo anche protocolli terapeutici specifici.
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Manca, Maria Francesca. "Investigation of the survival, migration and plasticity of bone marrow stromal cells transplanted into rat retinal lesion models of neurodegeneration." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415902.

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Biehl, Melanie [Verfasser], Gunther O. [Gutachter] Hofmann, Gunter [Gutachter] Spahn, and Kuno [Gutachter] Weise. "Metaanalyse zur Bestimmung von Risikofaktoren und pathophysiologischer Bedeutung der Bone Marrow Lesion / Melanie Biehl ; Gutachter: Gunther O. Hofmann, Gunter Spahn, Kuno Weise." Jena : Friedrich-Schiller-Universität Jena, 2018. http://d-nb.info/1170398049/34.

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Bastos, Victor Quinet de Andrade. "A ativação endotelial nos pacientes submetidos à quimioterapia em alta dose para transplante de medula óssea." Universidade Federal de Juiz de Fora (UFJF), 2018. https://repositorio.ufjf.br/jspui/handle/ufjf/7921.

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Introdução: o dano endotelial microvascular é um processo bem reconhecido como complicação do transplante de células tronco hematopoiéticas, os mecanismos dessa desordem ainda são pouco conhecidos. Diante desse cenário objetiva-se avaliar a relação entre marcadores inflamatórios e outros fatores que influenciam no consumo de plaquetas e o rendimento transfusional plaquetário, bem como a presença de eventos trombo embólicos e/ou vasculares em pacientes submetidos a condicionamento com quimioterapia em altas doses para transplante de células tronco hematopoiéticas. Método: análise prospectiva de pacientes, onde foram incluídos 25 pacientes que foram submetidos ao transplante de células tronco hematopoiéticas autólogo e alogênico. Os pacientes foram avaliados em relação a radioterapia previa, contagem de células CD 34 +, período de neutropenia, índice de massas corpórea, ferritina, Proteína C reativa relacionando esses fatores ao número de transfusões de plaquetas, refratariedade plaquetária e eventos vasculares como síndrome da obstrução sinusoidal e síndrome da enxertia. Resultado: das variáveis estudadas, apenas o IMC > 25 Kg/m2, apresentou um valor estatisticamente significativo (p = 0,003) em relação a menor necessidade transfusional de concentrado de plaquetas. Para a refratariedade plaquetária e/ou eventos vasculares nenhuma das variáveis foi estatisticamente significativa. Conclusão: pacientes com índice de massa corporal elevado apresentam menor necessidade transfusional de plaquetas. As condições encontradas nos três casos de refratariedade plaquetária e nos dois casos de eventos vasculares apresentam características semelhantes as descritas na literatura. Estudos relacionados à ativação endotelial e seus efeitos sobre o organismo devem ser estimulados.
Introduction: the objective of this Study is to evaluate the relationship between inflammatory markers and other factors that influence platelet consumption and platelet transfusion increment, as well as the presence of thromboembolic events in patients submitted to high-dose chemotherapy regimens for Bone Marrow Transplantation. Method: prospective analysis of patients, including 25 patients who underwent autologous and allogenic Bone Marrow Transplantation. The patients were evaluated in relation to previous radiotherapy, CD34+ cell count, period of neutropenia, body mass index, ferritin, C-reactive protein, relating these factors to the number of platelet transfusions, platelet refractoriness and vascular events such as sinusoidal obstruction syndrome and Engraftment Syndrome. Results: only body mass index > 25 Kg/m2 of the studied variables presented a statistically significant value (p = 0.003) in relation to the lower rates of platelet transfusion. For platelet refractoriness and/or vascular events none of the variables was statistically significant. Conclusion: the conditions found in the three cases of platelet refractoriness and in the two cases of vascular events have characteristics similar to those described in the literature. We agree with preexisting data reported in the literature, where patients with high BMI have lower need of platelets transfusion.
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Moraes, Luis Bruno da Cruz e. Alves de. "Análise dos efeitos do transplante de células mononucleares da medula óssea em camundongos submetidos à lesão eletrolítica do hipocampo dorsal." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-29092010-154904/.

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Diversos estudos sugerem que as células-tronco da medula óssea podem ser úteis no tratamento de lesões do tecido nervoso. O presente estudo investigou se a terapia com células medulares seria capaz de modificar os efeitos comportamentais de lesões no hipocampo. Células mononucleares da medula óssea marcadas com a proteína fluorescente verde (EGFP) foram transplantadas em camundongos C57BL/6 que tiveram o hipocampo dorsal danificado por lesão eletrolítica bilateral. Os resultados da avaliação comportamental no labirinto em cruz elevado mostraram que a lesão hipocampal produziu ansiólise, quadro que foi atenuado nos animais transplantados. Na análise imuno-histoquímica do tecido cerebral, foi observada presença limitada de células EGFP+ no cérebro dos animais lesionados. Dada a não recuperação da citoarquitetura tissular, acredita-se que os benefícios observados sobre o comportamento tenham resultado de um efeito parácrino das células mononucleares, que auxiliaram na ação de mecanismos endógenos para restituição parcial das funções do hipocampo.
Several studies suggest that stem cells from bone marrow may be useful in treating lesions of the nervous tissue. This study investigated if bone marrow cell therapy would be able to modify the behavioral effects of lesions in the hippocampus. Bone marrow mononuclear cells labeled with the enhanced green fluorescent protein (EGFP) were transplanted into C57BL/6 mice which had the dorsal hippocampus damaged by bilateral electrolytic lesion. The results of the behavioral assessment in the elevated plus-maze showed that the hippocampal lesion produced anxiolysis, an effect that was attenuated in transplanted animals. Immunohistochemical analysis of brain tissue revealed, however, a limited presence of EGFP+ cells into the brains of injured animals. Given the non-recovery of the tissue cytoarchitecture, it is believed that the observed benefits on the behavior resulted from a paracrine effect of the mononuclear cells, which possibly helped in the action of endogenous mechanisms for partial reimbursement of the hippocampal functions.
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Seigneurin, Daniel. "Cytologie quantitative de la maturation granulocytaire dans la moelle normale et au cours des syndromes myélodysplasiques." Grenoble 1, 1987. http://www.theses.fr/1987GRE10112.

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Muratovic, Dzenita. "Bone Marrow Lesions in Progression of Knee Osteoarthritis." Thesis, 2018. http://hdl.handle.net/2440/127110.

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Bone marrow lesions (BMLs) are magnetic resonance imaging (MRI)-identified pathological changes in subchondral bone, closely associated with joint pain and osteo-chondral structural degeneration in knee osteoarthritis (KOA). Despite the usefulness of BMLs as diagnostic and prognostic markers in KOA, what they represent at the tissue level remains unclear. Thus, the thesis aim was to perform a comprehensive investigation of BMLs at the tissue level and their relationship with the structural changes in KOA. We hypothesised that BML imaged using MRI reflect changes in subchondral tissue of proximal tibia that related to OA disease severity and/or progression. The first study provided comprehensive tissue characterization of BMLs detected using two [proton density fat saturated (PDFS) and T1)] specific MRI sequences. Multi-modal tissue level analyses of the whole depth of the tibial osteochondral unit were performed. The results from tissue level analyses showed that BMLs detected by specific MRI sequences associate strongly with the degree of structural change in the osteochondral unit in KOA. Specifically, BMLs detected by the combination of PDFS and T1 weighted MR-sequences represent an advanced structural stage of OA disease, while BMLs detected only by PDFS weighted sequence represent less severe OA, and potentially have the ability to resolve. In the second study, potential causal factors (mechanical loading and vascular pathology) of BML formation were investigated by assessing the accumulation of microdamage, and the qualitative and quantitative aspects of blood vessels in BML and non-BML tissue. Increased microdamage density and increased arteriolar density, with altered characteristics of vascular walls, were found in the zones of BML tissue, supporting the notion that both excessive and biomechanically unfavourable loading and vascular pathology contribute to the occurrence of BMLs in tibial subchondral bone tissue. In the third study, a potential role for components of the metabolic syndrome in BML development and its potential influences on the progression of KOA was investigated. Results from this study suggested that a combination of specific metabolic factors such as central obesity with BMI 30 or greater, dyslipidaemia, high blood pressure and high fasting glucose levels might promote the occurrence of BMLs in tibial subchondral bone tissue and that metabolic factors might contribute to the progressive osteochondral degeneration in KOA. The fourth study described microarchitectural changes in whole tibial plateaus (TP), based on the presence/absence of a BML. Tissue from healthy/control knees was also used to compare with that from OA with no BML and OA with BML, to better understand the course of OA disease and BML involvement in disease progression. In comparison with non-OA (control) subjects, the bone microstructure of the subchondral plate and trabeculae varies significantly between subregions of the TP in KOA. Secondly, in KOA subjects, two types of structural changes were identified, which were dependent on the presence or absence of a BML in the TP, and which related to the extent of cartilage degradation. Thirdly, the presence of a BML had implications for the microstructure of regions of the TP beyond the zone of the BML. In conclusion, this series of related studies demonstrates that BMLs as a feature of subchondral bone strongly associate with the progressive state of OA disease and therefore play a significant role in KOA pathogenesis. This demonstrated that BMLs are valuable imaging biomarkers of KOA and that BMLs might provide attractive targets for therapeutic intervention in OA.
Thesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2018
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Guang, Young. "Characterization of bone and bone marrow lesions in the osteoarthritic hip." Thesis, 2016. https://hdl.handle.net/2144/17088.

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Bone marrow lesions (BMLs) are common in osteoarthritis (OA) of the hip and knee and present as cysts in computed tomography scans. BMLs in knee OA are associated with pain, cartilage loss, and attrition of subchondral bone, suggesting that they play a key role in progression of OA. However, the etiology of BMLs remains unclear. The goal of this study was to better understand the changes that occur in bone in OA, through the characterization of BMLs, bone microarchitecture, and bone stiffness. Femoral heads obtained from patients undergoing total hip arthroplasty because of end-stage OA were imaged using micro-computed tomography (µCT) to identify the cysts. The bone volume fraction (BV/TV), bone mineral density (BMD), and tissue mineral density (TMD) were evaluated for two volumes of interest: an area immediately surrounding the cysts and a cylindrical core from the primary load-bearing region of the femoral head. Further, the cylindrical core was modeled using finite element analysis in order to evaluate the stiffness of this mechanically critical region. After imaging, the heads were sectioned and stained for histological analysis. Overall, the specimens exhibited wide variation in the number of cysts and cyst volume normalized by total volume of the femoral head (CV/TV). The cysts were found primarily in the subchondral bone underlying regions of damaged cartilage. The µCT images and histological sections revealed the presence of sclerotic bone around the cysts. vi The lesions themselves contained fibrous, fatty, osseous, and cartilaginous tissues. Lesions were absent from the cylindrical cores, and no correlations were found between core stiffness and any cyst properties. The cores were also found to have a higher bone volume fraction compared to values from published studies on cadaveric samples obtained from a pool of donors not specifically limited to those with end-stage OA. The cores also exhibited a modestly different dependence of apparent modulus on volume fraction, as compared to those published data. A pilot study was next carried out on the femoral necks from four of the patients. This study consisted of using nanoindentation to measure the modulus of cortical, trabecular, and periosteal bone. These preliminary results suggested that the moduli varied substantially among patients, and that the modulus of cortical tissue was in some locations for some patients, lower than that of trabecular tissue, despite published reports to the contrary in non-OA bone. The results of this project demonstrate that cysts associated with severe OA involve extensive perturbations in local bone morphology and cellular activity, and yet comparatively minimal disruption to the primary load-bearing region of the femoral head. These findings suggest that despite the association of cysts with symptoms of OA in the knee, cysts in hip OA are not strongly associated with a global loss of function of the primary bony structure of the joint. Further study of these cysts is necessary to identify their mechanistic relationship with the progression of hip OA.
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Books on the topic "Bone marrow lesions"

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Maksymowych, Walter P., and Robert G. W. Lambert. Imaging: sacroiliac joints. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0013.

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Radiography of the sacroiliac (SI) joints still forms the cornerstone of diagnosis of axial spondyloarthritis (axSpA), although its limitations in early disease preclude early diagnosis. Equivocal radiographic findings of sacroiliitis should be followed by MRI evaluation of the SI joints, especially if clinical suspicion of SpA is high. Routine diagnostic evaluation for SpA by MRI of the SI joints should include simultaneous evaluation of T1-weighted (T1W) and short tau inversion recovery (STIR) or T2 fat-suppressed scans. Bone marrow oedema (BME) in subchondral bone is the primary MRI feature that points to the diagnosis of SpA, although structural lesions such as erosion and fat metaplasia may also be evident in early disease and enhance confidence in the diagnosis. Both inflammatory and structural lesions in the SI joints on MRI can now be quantified in a reliable manner to facilitate therapeutic evaluation in clinical trials and for basic and clinical research.
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Purdue, Mark P., Jonathan N. Hofmann, Elizabeth E. Brown, and Celine M. Vachon. Multiple Myeloma. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0041.

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Multiple myeloma (MM) is the most common malignancy arising from plasma cells, fully differentiated B lymphocytes that produce the immunoglobulin (Ig) heavy- and light-chain molecules comprising antibodies. MM is characterized by an overproduction of clonal plasma cells in the bone marrow and, in most cases, monoclonal secretion of IgG, IgA, or light-chain Ig. Symptoms of end organ damage (hypercalcemia [C], renal failure [R], anemia [A], or bone lesions [B]), herein referred to as CRAB features, were traditionally a necessary criterion for diagnosing MM; however, improvements in treatment and diagnostic techniques have led to updated diagnostic criteria, enabling intervention among patients before the onset of organ damage. Multiple myeloma is an important cause of lymphoid malignancy (LM) mortality in Western populations. In the United States in 2015, MM was estimated to account for approximately one in every five newly diagnosed LMs, and one in every three LM-related deaths.
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Book chapters on the topic "Bone marrow lesions"

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Gill, Thomas J., and J. Richard Steadman. "Bone Marrow Stimulation Techniques: Microfracture, Drilling, and Abrasion." In Articular Cartilage Lesions, 63–72. New York, NY: Springer New York, 2004. http://dx.doi.org/10.1007/978-0-387-21553-2_7.

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Schajowicz, Fritz. "Marrow Tumors (Round-Cell Tumors)." In Tumors and Tumorlike Lesions of Bone, 301–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-49954-8_5.

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Lecouvet, F., P. Omoumi, A. Larbi, B. Tombal, N. Michoux, B. Vande Berg, and J. Malghem. "MRI for Response Assessment In Oncologic Bone Marrow Lesions." In Magnetic Resonance Imaging of the Bone Marrow, 121–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/174_2011_492.

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Gerards, R. M., I. C. M. van Eekeren, and C. Niek van Dijk. "Rehabilitation and Return-to-Sports Activity After Debridement and Bone Marrow Stimulation of Osteochondral Talar Defects." In Cartilage Lesions of the Ankle, 87–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46332-1_9.

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Lesnikov, Vladimir A., Elena N. Isaeva, Elena A. Korneva, and Walter Pierpaoli. "Melatonin Reconstitutes the Decreased CFU-S Content in the Bone Marrow of Hypothalamus-Lesioned Mice." In Role of Melatonin and Pineal Peptides in Neuroimmunomodulation, 225–31. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3756-4_25.

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Daly, Hesham El, and Mariam Amer. "Metastatic Lesions." In Diagnostic Bone Marrow Haematopathology, 298–313. Cambridge University Press, 2020. http://dx.doi.org/10.1017/9781316535042.017.

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Samet, Jonathan D. "Normal Bone Marrow and Benign Bone Marrow Lesions." In Musculoskeletal Imaging Volume 1, edited by Imran M. Omar, 287–92. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190938161.003.0058.

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Chapter 58 discusses normal bone marrow and benign bone marrow lesions. Bone marrow undergoes a predictable pattern of development throughout life, knowledge of which is essential for accurate assessment by the radiologist. It is a dynamic organ that can range in response from bone marrow failure to hyperactivity. Bone marrow can be affected by infectious, inflammatory, traumatic, and neoplastic causes, among other etiologies. This chapter discusses the normal appearance of bone marrow on imaging, with an emphasis on MRI. It will then discuss and show imaging examples of numerous benign entities that can affect the bone marrow. The reader will learn to predict the expected bone marrow appearance and therefore be able to distinguish this from benign pathologic states. The reader will also learn when to recommend a bone marrow aspiration/biopsy or further workup if confronted with an unexpected bone marrow appearance.
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Samet, Jonathan D. "Malignant Marrow Bone Tumors." In Musculoskeletal Imaging Volume 1, edited by Imran M. Omar, 293–300. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190938161.003.0059.

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Chapter 59 discusses malignant bone marrow tumors. Musculoskeletal radiologists are frequently confronted with bone marrow signal alterations on MRI that may represent physiologic variations or benign or malignant lesions. Although statistically most of these bone marrow signal abnormalities will be benign, distinguishing malignant from benign bone marrow entities is critical to patient management. This differentiation is not always possible on imaging, however, and biopsy may be necessary. This chapter will provide a practical approach to interpretation of diffuse and focal bone marrow abnormalities with an emphasis on malignant bone marrow lesions. With particular MRI criteria discussed, the reader will gain confidence in identifying malignant lesions and know for which lesions to recommend biopsy.
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Sharma, Om, and Violeta Mihailovic-Vucinic. "Bone and Bone Marrow Involvement." In Lesions of Sarcoidosis: A Problem Solving Approach, 127. Jaypee Brothers Medical Publishers (P) Ltd., 2014. http://dx.doi.org/10.5005/jp/books/12119_23.

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Lee, Christine U., and James F. Glockner. "Case 14.8." In Mayo Clinic Body MRI Case Review, edited by Christine U. Lee and James F. Glockner, 689–90. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199915705.003.0363.

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69-year-old man with a hepatic lesion that was detected on CT Coronal SSFSE image (Figure 14.8.1) demonstrates 2 hyperintense lesions in lower thoracic and upper lumbar vertebral bodies. Axial IP-OP 2D SPGR images (Figure 14.8.2) show that the superior-most lesion has increased signal intensity relative to adjacent bone marrow without significant dropout on the OP image. The lesion shows mild hyperintensity on an axial fat-suppressed FSE T2-weighted image (...
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Conference papers on the topic "Bone marrow lesions"

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Felson, D. "SP0152 Hypertension, bone marrow lesions and osteoarthritis (OA)." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.7863.

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Su, Yu, and Ting Li. "A portable cross-shape near-infrared spectroscopic detector for bone marrow lesions diagnosis." In SPIE BiOS, edited by Bernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney, et al. SPIE, 2016. http://dx.doi.org/10.1117/12.2210832.

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Su, Yu, and Ting Li. "Noninvasive optical measurement of bone marrow lesions: a Monte Carlo study on visible human dataset." In SPIE BiOS, edited by E. Duco Jansen. SPIE, 2016. http://dx.doi.org/10.1117/12.2210867.

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Yang, Jing, and Qing Yi. "Abstract 558: Constitutive activation of p38 MAPK signaling in tumor cells induces osteolytic bone lesions via regulating bone marrow microenvironment." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-558.

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Cai, G., D. Aitken, L. Laslett, C. Hill, L. March, A. E. Wluka, Y. Wang, et al. "OP0016 A multicentre randomised controlled trial of zoledronic acid for osteoarthritis of the knee with bone marrow lesions." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.1539.

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Kroon, F., S. van Beest, W. Damman, R. Liu, M. Reijnierse, and M. Kloppenburg. "SAT0512 MRI providing insights in association of synovitis and bone marrow lesions (BMLS) with pain in thumb base osteoarthritis (OA)." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.2879.

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Meng, T., S. Thayer, A. Venn, F. Cicuttini, L. March, T. Dwyer, A. Halliday, et al. "SAT0489 Association of childhood overweight measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.5668.

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Aubry, S., A. Danner, G. Tio, P. Omoumi, and E. Brumpt. "Contrast Ratio of Myeloma Focal Lesions Relative to Surrounding Bone Marrow Is Higher on T2-weighted Dixon Images Than on T1-weighted Images." In 26th Annual Scientific Meeting of the European Society of Musculoskeletal Radiology (ESSR). Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1692586.

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Baraliakos, X., H. Boehm, A. Samir Barakat, G. Schett, and J. Braun. "OP0242 Fatty lesions detected on mri scans in patients with ankylosing spondylitis are based on the deposition of fat in the vertebral bone marrow." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.7158.

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Seven, Sengül, Pernille Hededal, Mikkel Ǿstergaard, Lone Morsel-Carlsen, Inge Juul Sørensen, Birthe Bonde, Gorm Thamsborg, et al. "THU0364 THE DIAGNOSTIC UTILITY OF THE RELATION BETWEEN MRI BONE MARROW EDEMA AND OTHER TYPES OF MRI LESIONS IN THE SACROILIAC JOINTS IN AXIAL SPONDYLOARTHRITIS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.3227.

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