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1

Pathology of bone marrow and blood cells. 2nd ed. Baltimore, Md: Lippincott William & Wilkins, 2009.

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2

Diggs, L. W. The morphology of human blood cells. 6th ed. Abbott Park, Ill: Abbott Laboratories, 2003.

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3

University of Minnesota. Blood and Marrow Transplant Program. Blood and marrow transplantation: A patient's guide. 2nd ed. Minneapolis: Fairview Press, 2010.

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4

Harvey, John W. Atlas of veterinary hematology: Blood and bone marrow of domestic animals. Philadelphia, PA: W.B. Saunders, 2001.

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5

Maziarz, Richard T., and Susan Slater. Blood and marrow transplant handbook: Comprehensive guide for patient care. New York: Springer, 2011.

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6

Blood and marrow transplantation long term management: Prevention and complications. Chichester, West Sussex, UK: John Wiley & Sons, 2014.

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7

International Conference on the Occasion of the 60th Birthday of T.M. Fliedner (1989 Schloss Reisensburg, Germany). The hemopoietic stem cell: The origin and clinical usefulness of harvested peripheral blood stem cells : repair of stem cells and their kinetic properties in recovery from marrow injury by radiation and chemicals. Ulm: Universitätsverlag Ulm, 1990.

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8

Hokkaido Symposium on Transfusion Medicine (6th 1994 Sapporo-shi, Japan). Transfusion and hematopoietic stem cells: Proceedings of the 6th Hokkaido Symposium on Transfusional Medicine. Oxford: Blackwell Science, 1996.

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9

Provan, Drew, Trevor Baglin, Inderjeet Dokal, Johannes de Vos, and Hassan Al-Sader. Haematopoietic stem cell transplantation. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199683307.003.0009.

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Haemopoietic stem cell transplantation (SCT) - Indications for haemopoietic SCT - Allogeneic SCT - Autologous STC - Investigations for BMT/PBSCT - Pretransplant investigation of donors - Bone marrow harvesting - Peripheral blood stem cell mobilization and harvesting - Microbiological screening for stem cell cryopreservation - Stem cell transplant conditioning regimens - Infusion of cryopreserved stem cells - Infusion of fresh non-cryopreserved stem cells - Blood product support for SCT - Graft-versus-host disease (GvHD) prophylaxis - Acute GvHD - Chronic GvHD - Veno-occlusive disease (syn. sinusoidal obstruction syndrome) - Invasive fungal infections and antifungal therapy - CMV prophylaxis and treatment - Post-transplant vaccination programme and foreign travel - Longer term effect post-transplant - Treatment of relapse post-allogeneic SCT - Discharge and follow-up
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10

Collins, Graham, and Chris Bunch. Acute leukaemia. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0286.

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Acute leukaemias are rapidly progressive, clonal haematopoietic stem cell disorders resulting in the accumulation of immature blood cell precursors (known as blasts) in the bone marrow. There are two main types, defined by the presence of myeloid lineage or lymphoid markers on the blast cells: acute myeloid leukaemia and acute lymphoblastic leukaemia. This chapter addresses the causes, diagnosis, and management of the acute leukaemias.
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11

Albert, Tyler J., and Erik R. Swenson. The blood cells and blood count. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0265.

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Blood is a dynamic fluid consisting of cellular and plasma components undergoing constant regeneration and recycling. Like most physiological systems, the concentrations of these components are tightly regulated within narrow limits under normal conditions. In the critically-ill population, however, haematological abnormalities frequently occur and are largely due to non-haematological single- or multiple-organ pathology. Haematopoiesis originates from the pluripotent stem cell, which undergoes replication, proliferation, and differentiation, giving rise to cells of the erythroid, myeloid, and lymphoid series, as well as megakaryocytes, the precursors to platelets. The haemostatic system is responsible for maintaining blood fluidity and, at the same time, prevents blood loss by initiating rapid, localized, and appropriate blood clotting at sites of vascular damage. This system is complex, comprising both cellular and plasma elements, i.e. platelets, coagulation and fibrinolytic cascades, the natural intrinsic and extrinsic pathways of anticoagulation, and the vascular endothelium. A rapid, reliable, and inexpensive method of examining haematological disorders is the peripheral blood smear, which allows practitioners to assess the functional status of the bone marrow during cytopenic states. Red blood cells, which are primarily concerned with oxygen and carbon dioxide transport, have a normal lifespan of only 120 days and require constant erythropoiesis. White blood cells represent a summation of several circulating cell types, each deriving from the hematopoietic stem cell, together forming the critical components of both the innate and adaptive immune systems. Platelets are integral to haemostasis, and also aid our inflammatory and immune responses, help maintain vascular integrity, and contribute to wound healing.
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12

Pathology of Bone Marrow and Blood Cells. Lippincott Williams & Wilkins, 2004.

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13

Separation of Human Blood and Bone Marrow Cells. Butterworth-Heinemann, 1986.

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14

(Editor), E. J. Read, and Hans-Gunter Klein (Editor), eds. Standards for Bone Marrow and Peripheral Blood Progenitor Cells. American Association of Blood Banks, 1995.

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15

D, Irons Richard, ed. Toxicology of the blood and bone marrow. New York: Raven Press, 1985.

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16

Kerry, Atkinson, ed. Clinical bone marrow and blood stem cell transplantation. 2nd ed. Cambridge, U.K: Cambridge University Press, 2000.

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17

University of Minnesota. Blood and Marrow Transplant Program. and University of Minnesota. Amplatz Children's Hospital., eds. Blood and marrow transplantation: A patient's guide. 2nd ed. Minneapolis: Fairview Press, 2010.

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18

(Editor), Kerry Atkinson, Richard Champlin (Editor), Jerome Ritz (Editor), Willem E. Fibbe (Editor), Per Ljungman (Editor), and Malcom K. Brenner (Editor), eds. Clinical Bone Marrow and Blood Stem Cell Transplantation. 3rd ed. Cambridge University Press, 2003.

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19

Kerry, Atkinson, ed. Clinical bone marrow and blood stem cell transplantation. 3rd ed. New York, NY: Cambridge University Press, 2004.

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20

Gardiner, Clair M. Biological aspects of natural killer cell function: Analysis of cord blood, bone marrow and adult peripheral blood. 1996.

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21

Atlas of Veterinary Hematology: Blood and Bone Marrow of Domestic Animals. Saunders, 2001.

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22

Fairview-University Blood and Marrow Transplant Services., ed. Blood and marrow transplantation: A patient's guide to hematopoietic stem cell transplantation. Minneapolis, MN: Fairview, 2004.

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23

1945-, Deeg H. Joachim, and Deeg H. Joachim 1945-, eds. A guide to blood and marrow transplantation. 3rd ed. Berlin: Springer, 1999.

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24

McCann, Shaun R. Red blood cells. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0004.

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Red blood cells, erythrocytes, are unique in that they do not contain a nucleus. This fact facilitates the study of their metabolism. Erythrocytes contain the protein pigment haemoglobin, which is in solution in the cells and consists of globin chains and iron. In this chapter, the development of the understanding of erythrocytes is linked to the blood conditions haemolytic anaemia and paroxysmal nocturnal haemoglobinuria. Premature destruction of erythrocytes, in the absence of blood loss, is termed haemolysis. If the bone marrow is unable to compensate adequately, then anaemia ensues and the condition is called haemolytic anaemia. The underlying defect is a deficiency in the activity of the enzyme glucose-6-phosphate dehydrogenase, termed G6PD deficiency.
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25

Susan, Ezzone, and Schmit-Pokorny Kim, eds. Blood and marrow stem cell transplantation: Principles, practice, and nursing insights. 3rd ed. Sudbury, Mass: Jones and Bartlett Publishers, 2006.

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26

Bakitas, Whedon Marie, and Wujcik Debra, eds. Blood and marrow stem cell transplantation: Principles, practice, and nursing insights. 2nd ed. Sudbury, Mass: Jones and Bartlett Publishers, 1997.

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27

N, Winter Jane, ed. Blood stem cell transplantation. Boston: Kluwer Academic Publishers, 1997.

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28

Armitage, James. Blood Stem Cell Transplantation. Taylor & Francis, 1998.

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29

(Editor), Marie Bakitas Whedon, and Debra Wujcik (Editor), eds. Blood and Marrow Stem Cell Transplantation, Second Edition (Jones and Bartlett Series in Oncology). 2nd ed. Jones & Bartlett Publishers, 1997.

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30

Savani, Bipin N. Blood and Marrow Transplantation Long-Term Management: Prevention and Complications. Wiley & Sons, Limited, John, 2013.

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31

Savani, Bipin N. Blood and Marrow Transplantation Long-Term Management: Prevention and Complications. Wiley & Sons, Incorporated, John, 2013.

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32

Savani, Bipin N. Blood and Marrow Transplantation Long-Term Management: Prevention and Complications. Wiley & Sons, Incorporated, John, 2013.

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33

Savani, Bipin N. Blood and Marrow Transplantation Long-Term Management: Prevention and Complications. Wiley & Sons, Incorporated, John, 2013.

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34

H, Kelley Cathy, ed. Home care management of the blood cell transplant patient. 3rd ed. Sudbury: Jones and Bartlett, 1998.

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35

Cesare, Peschle, Fondazione internazionale Menarini, Istituto superiore di sanità (Italy), and World Health Organization, eds. Normal and neoplastic blood cells: From genes to therapy. New York, N.Y: New York Academy of Sciences, 1987.

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36

R, Koller Manfred, Palsson Bernhard, and Masters J. R. W, eds. Primary hematopoietic cells. Dordrecht: Kluwer Academic Publishers, 1999.

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37

Bunch, Chris. Normal blood function. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0277.

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This chapter reviews normal blood function and disorders of haemopoiesis. Blood consists of cells of three main types, suspended in plasma. The cellular component comprises about 40%–50% of the total volume and consists of red cells (erythrocytes), white cells (leucocytes), and platelets. Blood cells are formed from progenitor cells in the bone marrow by haemopoiesis, a process of proliferation and differentiation. Failure of haemopoiesis usually results from damage to proliferating marrow cells by cytotoxic drugs or radiation, haemopoietic malignancy, or a combination of the two.
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38

Human Cell Culture: Volume IV: Primary Hematopoietic Cells (Human Cell Culture). Springer, 1999.

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39

Nguyen, Doyen, and Lawrence Diamond. Diagnostic Hematology: A Pattern Approach (Book with CD-ROM). A Hodder Arnold Publication, 2000.

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40

Bunch, Chris. Diagnosis and investigation in haematology. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0278.

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This chapter addresses the interpretation of the full blood count, blood film, bone marrow examination, and related tests in the diagnosis of haematological disorders. Examination of a stained blood film, which should always be requested if a blood count abnormality cannot readily be explained by the clinical context, may give clues to the cause of the abnormality or prove diagnostic. Examination of the bone marrow is essential to the proper evaluation and diagnosis of many haematological disorders. The simplest form of marrow examination involves needle aspiration of marrow cells from the posterior iliac crest; smears are made and stained in the same way as a blood film. Bone marrow can also be biopsied for histological examination, at the same time as marrow aspiration.
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41

Steensma, David P. Benign Hematology. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0294.

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The major forms of benign hematologic conditions are anemia, neutropenia, transfusion reactions, Gaucher disease, and porphyria. Anemia is a sign of disease rather than a disease itself. Anemia results from 1 or more of 3 pathologic mechanisms: inadequate production of red blood cells (RBCs) by the bone marrow, blood loss, or premature destruction of RBCs. The major causes of neutropenia include hematologic neoplasm, metastatic neoplasm involving the marrow, irradiation, vitamin B12 deficiency and folate deficiency, drugs, infections, congenital or acquired primary disorders of hematopoiesis, autoimmune neutropenia, hypersplenism, hemodilution, and benign idiopathic neutropenia. The porphyrias are enzyme disorders that are autosomal dominant with low disease penetrance, except for congenital erythropoietic porphyria, which is autosomal recessive, and porphyria cutanea tarda, which may be acquired and is associated with hepatitis C and hemochromatosis.
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42

McCann, Shaun R. Radiation and transplantation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0006.

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There is a paradoxical relationship between ionizing radiation and leukaemia. On the one hand, it is known that exposure to high doses of ionizing radiation causes leukaemia; on the other hand, the preparative regimens for stem cell transplantation, which can cure leukaemia, often contain total body irradiation. This chapter discusses the effect war has had on medical technology, with specific regard to the use of stem cells for the treatment of blood disorders such as leukaemia and sickle cell anaemia. The transfer of laboratory techniques to the clinical practice of stem cell transfer and bone marrow transplantation is also discussed.
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43

Lance, Eboni I., and Andrew W. Zimmerman. Sickle Cell Anemia. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0079.

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Sickle cell disease is a genetic hematological disorder involving red blood cells that become deformed when stressed. Patients with homozygous hemoglobin SS disease often have multiple systemic and neurologic complications, particularly stroke. Intellectual disability is commonly seen in the population, in patients with and without a history of stroke, attributed to different underlying mechanisms of brain injury. Autism is rare and not described in sickle cell disease in the literature to date. Many treatments (chronic transfusion therapy, hydroxyurea, bone marrow transplant) are in trials at this time to see if risk of stroke and other neurologic complications can be reduced (ClinicalTrials.gov identifiers: NCT01425307, NCT01389024, NCT00152113).
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