Relevant bibliographies by topics / Bone Diseases, Metabolic – physiopathology

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Bone Diseases, Metabolic – physiopathology'

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Published: 29 July 2024
Last updated: 31 July 2024

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Journal articles on the topic "Bone Diseases, Metabolic – physiopathology"

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Izzo, Marcello, Albino Carrizzo, Carmine Izzo, Enrico Cappello, Domenico Cecere, Michele Ciccarelli, Patrizia Iannece, Antonio Damato, Carmine Vecchione, and Francesco Pompeo. "Vitamin D: Not Just Bone Metabolism but a Key Player in Cardiovascular Diseases." Life 11, no. 5 (May 18, 2021): 452. http://dx.doi.org/10.3390/life11050452.

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Vitamin D is the first item of drug expenditure for the treatment of osteoporosis. Its deficiency is a condition that affects not only older individuals but also young people. Recently, the scientific community has focused its attention on the possible role of vitamin D in the development of several chronic diseases such as cardiovascular and metabolic diseases. This review aims to highlight the possible role of vitamin D in cardiovascular and metabolic diseases. In particular, here we examine (1) the role of vitamin D in diabetes mellitus, metabolic syndrome, and obesity, and its influence on insulin secretion; (2) its role in atherosclerosis, in which chronic vitamin D deficiency, lower than 20 ng/mL (50 nmol/liter), has emerged among the new risk factors; (3) the role of vitamin D in essential hypertension, in which low plasma levels of vitamin D have been associated with both an increase in the prevalence of hypertension and diastolic hypertension; (4) the role of vitamin D in peripheral arteriopathies and aneurysmal pathology, reporting that patients with peripheral artery diseases had lower vitamin D values than non-suffering PAD controls; (5) the genetic and epigenetic role of vitamin D, highlighting its transcriptional regulation capacity; and (6) the role of vitamin D in cardiac remodeling and disease. Despite the many observational studies and meta-analyses supporting the critical role of vitamin D in cardiovascular physiopathology, clinical trials designed to evaluate the specific role of vitamin D in cardiovascular disease are scarce. The characterization of the importance of vitamin D as a marker of pathology should represent a future research challenge.
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Biver, Emmanuel, Pierre Hardouin, and Joseph Caverzasio. "The “bone morphogenic proteins” pathways in bone and joint diseases: Translational perspectives from physiopathology to therapeutic targets." Cytokine & Growth Factor Reviews 24, no. 1 (February 2013): 69–81. http://dx.doi.org/10.1016/j.cytogfr.2012.06.003.

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Grill, Vivian, and T. John Martin. "Metabolic bone diseases." Medical Journal of Australia 163, no. 1 (July 1995): 38–41. http://dx.doi.org/10.5694/j.1326-5377.1995.tb126087.x.

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SEINO, YOSHIKI. "Metabolic bone diseases." Pediatrics International 39, no. 4 (August 1997): 478. http://dx.doi.org/10.1111/j.1442-200x.1997.tb03623.x.

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Horvai, Andrew E., and Brendan F. Boyce. "Metabolic bone diseases." Seminars in Diagnostic Pathology 28, no. 1 (February 2011): 13–25. http://dx.doi.org/10.1053/j.semdp.2011.02.004.

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Dubois-Deruy, Emilie, Yara El Masri, Annie Turkieh, Philippe Amouyel, Florence Pinet, and Jean-Sébastien Annicotte. "Cardiac Acetylation in Metabolic Diseases." Biomedicines 10, no. 8 (July 29, 2022): 1834. http://dx.doi.org/10.3390/biomedicines10081834.

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Lysine acetylation is a highly conserved mechanism that affects several biological processes such as cell growth, metabolism, enzymatic activity, subcellular localization of proteins, gene transcription or chromatin structure. This post-translational modification, mainly regulated by lysine acetyltransferase (KAT) and lysine deacetylase (KDAC) enzymes, can occur on histone or non-histone proteins. Several studies have demonstrated that dysregulated acetylation is involved in cardiac dysfunction, associated with metabolic disorder or heart failure. Since the prevalence of obesity, type 2 diabetes or heart failure rises and represents a major cause of cardiovascular morbidity and mortality worldwide, cardiac acetylation may constitute a crucial pathway that could contribute to disease development. In this review, we summarize the mechanisms involved in the regulation of cardiac acetylation and its roles in physiological conditions. In addition, we highlight the effects of cardiac acetylation in physiopathology, with a focus on obesity, type 2 diabetes and heart failure. This review sheds light on the major role of acetylation in cardiovascular diseases and emphasizes KATs and KDACs as potential therapeutic targets for heart failure.
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Dumond Bourie, Aurore, Jean-Baptiste Potier, Michel Pinget, and Karim Bouzakri. "Myokines: Crosstalk and Consequences on Liver Physiopathology." Nutrients 15, no. 7 (March 31, 2023): 1729. http://dx.doi.org/10.3390/nu15071729.

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Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease mainly characterized by the hepatic accumulation of lipid inducing a deregulation of β-oxidation. Its advanced form is non-alcoholic steatohepatitis (NASH), which, in addition to lipid accumulation, induces hepatocellular damage, oxidative stress and fibrosis that can progress to cirrhosis and to its final stage: hepatocellular carcinoma (HCC). To date, no specific therapeutic treatment exists. The implications of organ crosstalk have been highlighted in many metabolic disorders, such as diabetes, metabolic-associated liver diseases and obesity. Skeletal muscle, in addition to its role as a reservoir and consumer of energy and carbohydrate metabolism, is involved in this inter-organs’ communication through different secreted products: myokines, exosomes and enzymes, for example. Interestingly, resistance exercise has been shown to have a beneficial impact on different metabolic pathways, such as lipid oxidation in different organs through their secreted products. In this review, we will mainly focus on myokines and their effects on non-alcoholic fatty liver disease, and their complication: non-alcoholic steatohepatitis and HCC.
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Sánchez-Oliver, Antonio Jesús. "Obesity Phisiopathology: Current Perspectives." Journal of Nutritional Biology 4, no. 1 (December 20, 2017): 21. http://dx.doi.org/10.18314/jnb.v4i1.160.

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Obesity is a global health problem, being considered one of the most serious and prevalent non-communicable diseases of the 21st century. It is currently understood as a multifactorial chronic condition associated with potentially serious complications whose treatment requires a multidisciplinary approach, given its huge clinical impact and associated health-carecost. Besides, properly tackling obesity requires a founded knowledge of its specific physiopathology is required. Together withthe rise in adiposity, a series of cellular processes happen, which cause several metabolic changes that drive to a vicious circle ofvisceral fat increase. This process in enhanced by genetic and environmental factors associated to multiple diseases (metabolic,cardiovascular, osteoarticular, etc.) that increase morbidity and mortality. The aim of this review is to introduce the currentperspectives on obesity physiopathology in a simple and didactic manner, in order to contribute to a better approach by thedifferent professionals that work with obesity in their everyday practice.
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Rossi, Francesca, Chiara Tortora, Marco Paoletta, Maria Maddalena Marrapodi, Maura Argenziano, Alessandra Di Paola, Elvira Pota, Daniela Di Pinto, Martina Di Martino, and Giovanni Iolascon. "Osteoporosis in Childhood Cancer Survivors: Physiopathology, Prevention, Therapy and Future Perspectives." Cancers 14, no. 18 (September 6, 2022): 4349. http://dx.doi.org/10.3390/cancers14184349.

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The improvement of chemotherapy, radiotherapy, and surgical interventions, together with hematopoietic stem cell transplantation, increased childhood cancer survival rate in the last decades, reaching 80% in Europe. Nevertheless, anti-cancer treatments are mainly responsible for the onset of long-term side effects in childhood cancer survivors (CCS), including alterations of the endocrine system function and activity. In particular, the most frequent dysfunction in CCS is a metabolic bone disorder characterized by low bone mineral density (BMD) with increased skeletal fragility. BMD loss is also a consequence of a sedentary lifestyle, malnutrition, and cancer itself could affect BMD, thus inducing osteopenia and osteoporosis. In this paper, we provide an overview of possible causes of bone impairment in CCS in order to propose management strategies for early identification and treatment of skeletal fragility in this population.
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Sinigaglia, L. "Metabolic bone diseases: an overview." Reumatismo 66, no. 2 (July 28, 2014): 109. http://dx.doi.org/10.4081/reumatismo.2014.783.

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Dissertations / Theses on the topic "Bone Diseases, Metabolic – physiopathology"

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Laketic-Ljubojevic, Ira. "Glutamate signalling in bone cells." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311080.

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Taylor, Amanda Faith. "The role of glutamate in bone formation in vitro." Thesis, University of York, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341824.

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Samnegård, Eva. "Pharmacological and hormonal effects on bone with emphasis on osteoporosis : experimental studies in the rat /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-89428-08-0/.

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Karunaratne, Malintha P. Angelo. "Analysis of alterations in matrix quality at nanoscale in metabolic bone diseases using synchrotron X-ray diffraction." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8490.

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Bone diseases such as osteoporosis and rickets cause significant reduction in bone quantity and quality, leading to mechanical abnormalities. While the reduction of bone quantity can be assessed using clinical tools like DXA and pQCT, there is little quantitative knowledge of how altered bone quality in diseased bone increases fracture risk. There is a clear need to develop high-resolution diagnostic techniques to close the gap between onset of fracture relevant changes and diagnosis. Here, a functional imaging technique (in situ synchrotron X-ray imaging with micromechanics) was developed to measure alterations in fibrillar deformation mechanisms in rickets, glucocorticoid-induced osteoporosis (GIOP), and premature ageing. During applied loading, percentage shifts in Bragg peak positions arising from the meridional collagen stagger, measured from the small angle X-ray scattering (SAXS) patterns, give fibrillar level strain as a function of applied stress in real time. To link nanostructural changes to altered fracture risk and deformability, well defined animal (mouse) models created via N-ethylnitrosurea mutagenesis were used. The fibril modulus, maximum fibril strain and fibril-to-tissue strain ratio were determined, complemented by quantitative backscattered scanning electron microscopy and microcomputed tomography to measure microscale mineralisation. A significant reduction of fibril modulus and enhancement of maximum fibril strain was found in rickets and GIOP mice. A significantly larger fibril strain/tissue strain ratio was found in GIOP mice compared to wild-type mice, indicative of a lowered mechanical competence at the bone matrix level. The effects of altered in vivo muscular force distributions on the skeletal system in rickets were measured using position resolved scanning SAXS. Increase of mineral nanoplatelet alignment is observed in wild-type mice near zones of large in-vivo muscle force but not in rachitic mice. These results demonstrate the ability of synchrotron-based in situ X-ray nanomechanical imaging to identify functional alterations in nanoscale bone quality in metabolic bone diseases.
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Simmons, Natalie Renee. "CHEST X-RAY CLUES TO OSTEOPOROSIS: CRITERIA, CORRELATIONS, AND CONSISTENCY." Yale University, 2009. http://ymtdl.med.yale.edu/theses/available/etd-04162009-161245/.

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The purpose of this study was to determine whether radiologists could accurately assess osteopenia on chest plain films. Two chest radiologists evaluated lateral chest films from 100 patients (80 female and 20 male), ranging in age from 16 to 86 years, for osteopenia and its associated findings. Intra- and interobserver agreement was determined using weighted kappa statistics, and accuracy was assessed by making comparisons to bone mineral density as measured by the non-invasive gold standard of dual-energy x-ray absorptiometry (DXA). Overall, radiologists were good at identifying signs of late, but not early, disease. Intraobserver consistency was substantial for fish vertebrae (Kw1=0.638; Kw2=0.0.712) with moderate interobserver agreement (Kw=0.45). Similarly for wedged vertebrae, intraobserver consistency was substantial to moderate (Kw1=0.654; Kw2=0.533) with substantial interobserver agreement (Kw=0.622). These radiographic signs correlated with true disease as shown by high specificity values. Therefore, this study indicates that if osteopenia is suspected (i.e., there is a wedge or fish vertebra) or its associated features are seen on a CXR, it is crucial for radiologists to comment on it. The literature suggests that referring physicians do not pay attention to such findings in radiology reports. Radiologists could effect change in clinical treatment by not burying these findings in the report body, but instead putting it in the impression, along with a recommendation that the finding be followed up with DXA. Because effective interventions for women with osteoporosis exist, the results of this study will contribute to a major change in the practice of chest radiology and improve womens health by preventing the devastating disability associated with osteoporosis.
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Ueno, Melise Jacon Peres [UNESP]. "Efeitos do desuso e da deficiência de estrógeno sobre a microarquitetura óssea e suas propriedades biomecânicas." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/134197.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O objetivo desse estudo foi analisar se há diferenças no efeito do desuso e da deficiência de estrógeno sobre o tecido ósseo trabecular e cortical, e se estes efeitos influenciam na qualidade do tecido ósseo aumentando sua fragilidade. Para este estudo, 30 ratas Wistar com 19 semanas de idade foram distribuídas nos grupos: controle (CON), descarregamento dos membros posteriores (HLU) e ovariectomizado (OVX). As análises da densidade óssea in vivo (DXA) dos fêmures e tíbias e as dosagens plasmáticas de cálcio, fósforo, fosfatase alcalina, TRAP (espectrofotometria) e E2 (ELISA) foram realizadas no início e fim do experimento, com 19 e 27 semanas de idade respectivamente. Na 27a semana, os fêmures e as tíbias foram desarticulados e armazenados para avaliar a microestrutura do osso trabecular e cortical (microtomografia computadorizada), além das propriedades biomecânicas do colo femoral e da diáfise femoral e tibial (ensaio mecânico). O grupo HLU apresentou diminuição na concentração plasmática de cálcio e atividade da fosfatase alcalina total, diminuição na DMOa do fêmur com aumento na porosidade cortical e diminuição na resistência óssea, entretanto, não foram observadas estas alterações na tíbia. O grupo OVX apresentou diminuição nas concentrações plasmáticas de cálcio, diminuição da DMOa do fêmur, deterioração trabecular no fêmur e na tíbia, com maior deterioração nas trabéculas ósseas tibiais, sem alteração na resistência óssea em ambos os ossos. Esses resultados demonstram que apesar do grupo HLU e OVX apresentassem alterações na densidade mineral óssea e microarquitetura óssea, podemos concluir que o desuso determinou maior perda no tecido cortical e na resistência óssea em relação à deficiência de estrógeno. Portanto, as análises da estrutura do tecido cortical, como a porosidade cortical, podem ser preponderantes para prever o risco de fratura
The objective of this study was to analyze whether there are differences in the effect of disuse and estrogen deficiency on trabecular and cortical bone tissue, and whether these effects influence the quality of bone tissue increasing its fragility. For this study, 30 Wistar rats with 19 weeks old, were divided into groups: control (CON), hindlimb unloading (HLU) and ovariectomy (OVX). In vivo analysis of bone density (DXA) from femurs and tibias and plasma levels of calcium, phosphorus, alkaline phosphatase, TRAP (spectrophotometry) and E2 (ELISA) were performed at the beginning and end of the experiment, and 19 age 27 weeks, respectively. In the 27th week, the femur and tibia were disjointed and stored to assess the microstructure of trabecular and cortical bone (microcomputed tomography) and biomechanical properties of the femoral neck and femoral shaft and tibial (mechanical tests). The HLU group showed a decrease in plasma calcium concentration and total alkaline phosphatase activity, decreased femoral BMAD with increased cortical porosity and decrease in bone strength, however, there were no such changes in the tibia. The OVX group showed a decrease in plasma concentrations of calcium, decreased femoral BMAD, trabecular deterioration in the femur and tibia, with further deterioration in the tibial trabecular bone, with no change in bone strength in both bones. These results demonstrate that although the HLU and OVX group showed changes in bone mineral density and bone microarchitecture, we can conclude that the in disuse determined higher cortical tissue loss and bone strength relative to estrogen deficiency. Therefore, the analysis of the cortical tissue structure, such as cortical porosity can be prevalent to predict fracture risk
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Ueno, Melise Jacon Peres. "Efeitos do desuso e da deficiência de estrógeno sobre a microarquitetura óssea e suas propriedades biomecânicas /." Araçatuba, 2015. http://hdl.handle.net/11449/134197.

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Orientador: Mário Jefferson Quirino Louzada
Banca: William Dias Belangero
Banca: José Carlos Camargo Filho
Resumo: O objetivo desse estudo foi analisar se há diferenças no efeito do desuso e da deficiência de estrógeno sobre o tecido ósseo trabecular e cortical, e se estes efeitos influenciam na qualidade do tecido ósseo aumentando sua fragilidade. Para este estudo, 30 ratas Wistar com 19 semanas de idade foram distribuídas nos grupos: controle (CON), descarregamento dos membros posteriores (HLU) e ovariectomizado (OVX). As análises da densidade óssea in vivo (DXA) dos fêmures e tíbias e as dosagens plasmáticas de cálcio, fósforo, fosfatase alcalina, TRAP (espectrofotometria) e E2 (ELISA) foram realizadas no início e fim do experimento, com 19 e 27 semanas de idade respectivamente. Na 27a semana, os fêmures e as tíbias foram desarticulados e armazenados para avaliar a microestrutura do osso trabecular e cortical (microtomografia computadorizada), além das propriedades biomecânicas do colo femoral e da diáfise femoral e tibial (ensaio mecânico). O grupo HLU apresentou diminuição na concentração plasmática de cálcio e atividade da fosfatase alcalina total, diminuição na DMOa do fêmur com aumento na porosidade cortical e diminuição na resistência óssea, entretanto, não foram observadas estas alterações na tíbia. O grupo OVX apresentou diminuição nas concentrações plasmáticas de cálcio, diminuição da DMOa do fêmur, deterioração trabecular no fêmur e na tíbia, com maior deterioração nas trabéculas ósseas tibiais, sem alteração na resistência óssea em ambos os ossos. Esses resultados demonstram que apesar do grupo HLU e OVX apresentassem alterações na densidade mineral óssea e microarquitetura óssea, podemos concluir que o desuso determinou maior perda no tecido cortical e na resistência óssea em relação à deficiência de estrógeno. Portanto, as análises da estrutura do tecido cortical, como a porosidade cortical, podem ser preponderantes para prever o risco de fratura
Abstract: The objective of this study was to analyze whether there are differences in the effect of disuse and estrogen deficiency on trabecular and cortical bone tissue, and whether these effects influence the quality of bone tissue increasing its fragility. For this study, 30 Wistar rats with 19 weeks old, were divided into groups: control (CON), hindlimb unloading (HLU) and ovariectomy (OVX). In vivo analysis of bone density (DXA) from femurs and tibias and plasma levels of calcium, phosphorus, alkaline phosphatase, TRAP (spectrophotometry) and E2 (ELISA) were performed at the beginning and end of the experiment, and 19 age 27 weeks, respectively. In the 27th week, the femur and tibia were disjointed and stored to assess the microstructure of trabecular and cortical bone (microcomputed tomography) and biomechanical properties of the femoral neck and femoral shaft and tibial (mechanical tests). The HLU group showed a decrease in plasma calcium concentration and total alkaline phosphatase activity, decreased femoral BMAD with increased cortical porosity and decrease in bone strength, however, there were no such changes in the tibia. The OVX group showed a decrease in plasma concentrations of calcium, decreased femoral BMAD, trabecular deterioration in the femur and tibia, with further deterioration in the tibial trabecular bone, with no change in bone strength in both bones. These results demonstrate that although the HLU and OVX group showed changes in bone mineral density and bone microarchitecture, we can conclude that the in disuse determined higher cortical tissue loss and bone strength relative to estrogen deficiency. Therefore, the analysis of the cortical tissue structure, such as cortical porosity can be prevalent to predict fracture risk
Mestre
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Ahmad, Tashfeen. "Diabetic osteopathy : a study in the rat /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-615-4/.

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Fernandes, Fernanda [UNESP]. "Análise do colo femoral de ratas adultas e senis após tratamento com ocitocina." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143823.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Este estudo teve como objetivo analisar e comparar a ação da ocitocina (OT) no metabolismo ósseo de ratas Wistar cíclicas (12 meses) e acíclicas (18 meses/período de periestropausa). Os animais foram distribuídos em quatro grupos: (1) animais com 12 meses que receberam injeção com veículo NaCl (Veh/12); (2) animais com 12 meses que receberam injeção de OT (Ot / 12); (3) animais com 18 meses que receberam injeção com veículo NaCl (Veh/18); (4) animais com 18 meses que receberam injeção de OT (Ot / 18). Cada grupo foi composto por 8 animais. Os animais receberam duas injeções intraperitoneais de NaCl (0,15 M – grupo controle) ou OT (134 ug / kg – grupo tratado) com 12 horas de intervalo. Força, microarquitetura e biomarcadores ósseos [fosfatase alcalina (FAL) e fosfatase ácida resistente ao tartarato (TRAP)] foram analisados. Imunoistoquímica foi realizada para fator de transcrição relacionado com o Runt 2 (RUNX2), osterix (OSX), osteocalcina (OCN), osteopontina (OPN), proteína óssea morfogenética 2 e 4 (BMP-2/4), periostina (PER), esclerostina (ESC) e TRAP. Os animais que receberam OT demonstraram melhora significante na dosagem plasmática: aumento na FAL dos animais de 12 meses (p < 0,0001) e 18 meses (p = 0,0138); diminuição na TRAP dos animais de Ot / 12 (p = 0,0465) e Ot / 18 (p = 0,0045). Houve melhora nos parâmetros biomecânicos: força máxima (N) do grupo Ot / 18 (p = 0,0003); rigidez óssea (x103N/mm) do grupo Ot / 12 (p = 0,0223) e Ot / 18 (p = 0,0145); microarquitetura óssea cortical do grupo Ot / 18 para Ct.Ar (mm2 ) (p = 0,0416) e Ct.Po (%) (p = 0,0102); microarquitetura óssea trabecular para Tb.N (1/mm) (p = 0,0016) e Tb.Sp (p = 0,00010); todos os grupos foram comparados ao seus respectivos controles (Veh/12; Veh/18). Em resumo, os resultados demonstraram que a administração de OT foi eficaz para prevenir a perda de massa óssea em ratas Wistar velhas com hipoestrogenismo, reforçando este agente anabólico como forte alternativa terapêutica para prevenção e tratamento da osteoporose (OP), reduzindo os índices da doença e fraturas osteoporóticas.
This study aimed to analyze and compare the acting of oxytocin (OT) on bone metabolism of cyclic (12 months) and acyclic Wistar rats (18 months/peri-estropause period). Animals were allocated to four groups: (1) animals with 12 months that received vehicle injection NaCl (Veh/12); (2) animals with 12 months that received OT injection (Ot / 12); (3) animals with 18 months that received vehicle (Veh/18) and (4) animals with 18 months that received OT injection (Ot / 18). Eight animals composed each group. The animals received two intraperitoneal injections of NaCl (0.15 M - control group) or OT (134 ug / kg - treated groups) with 12 hours apart. Bone strength, microarchitecture, and biomarkers [alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP)] were assessed. Immunohistochemistry was performed for runt-related transcription factor 2 (RUNX2), osterix (OSX), osteocalcin (OCN), osteopontin (OPN), bone morphogenetic protein 2 and 4 (BMP- 2/4), periostin (PER), sclerostin (ESC) and TRAP. Animals that received OT showed significant improvements at plasma assay: increase in the ALP from the animals with 12 months (p < 0.0001) and 18 months (p = 0.0138); decrease in the TRAP from the Ot / 12 (p = 0.0465) and Ot / 18 (p = 0.0045). There was improvements at biomechanical parameters: maximum load (N) from the Ot / 18 (p = 0.0003); bone stiffness (x103N/mm) from the Ot / 12 (p = 0.0223) and Ot / 18 (p = 0.0145); cortical bone microarchitecture from the Ot / 18 to Ct.Ar (mm2 ) (p = 0.0416) and Ct.Po (%) (p = 0.0102); trabecular bone microarchitecture to Tb.N (1/mm) (p = 0.0016) and Tb.Sp. (p = 0.00010); all groups compared to its respective controls (Veh/12; Veh/18). In summary, the results showed the OT administration was effective to prevent the bone loss in old Wistar rats with hypoestrogenism, reforcing this anabolic agent as powerful therapeutic alternative to prevention and treatment for osteoporosis (OP), to reduce the rates of disease and osteoporotic fractures.
CNPq: 133834/2014-0
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Coêlho, Juliana de Carvalho Apolinário. "Efeito do ultra-som de baixa potência na reparação óssea em ratos sob ausência de carga : análise densitométrica e biomecânica /." Araçatuba : [s.n.], 2008. http://hdl.handle.net/11449/92201.

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Orientador: Mário Jefferson Quirino Louzada
Banca: Ivania Garavella
Banca: Leda Maria Pescinini Salzedas
Resumo: A literatura apresenta que a resposta de reparo ósseo pode ser acentuada pela estimulação física, mecânica ou eletromagnética. Há evidências de que o ultra-som - US - de baixa potência pode acelerar a regeneração óssea. Este trabalho objetivou verificar o efeito do US no defeito ósseo, criado experimentalmente, em tíbias de ratos sob ausência de carga (suspenso pela cauda) por meio de análise densitométrica e biomecânica. Trinta Rattus novergicus albinus, Wistar, adultos, divididos em 3 grupos: G1 (n=10), não suspenso - experimento de 15 dias; G2 (n=10), suspenso pela cauda - experimento de 15 dias e, G3 (n=10), suspensos pela cauda, experimento de 36 dias. Os animais foram submetidos à osteotomia em ambas as tíbias e à aplicação do US (freqüência de 1,5 MHz, ciclo 1:4, 30mW/cm2) na direita (12 sessões de 20 minutos). O G3 somente foi osteotomizado após 21º dia de suspensão. Para análises densitométrica utilizou-se densitômetro DPXLunar ™, sistema digital Digora e o programa computacional Image J ; para ensaio mecânico usou máquina universal de ensaio EMIC . Os resultados do Conteúdo Mineral Ósseo (g), Área (cm²), Densidade Mineral Óssea (g/cm²) e da Densidade Óssea (mmAl) observadas nas tíbias, assim como a Força Máxima (N) e Rigidez (x103N/m) não demonstraram diferenças significantes (tratadas versus controle de cada grupo), possivelmente pelo menor tempo de tratamento com relação aos trabalhos encontrados na literatura. Concluindo que o Ultra-Som de baixa potência não acelerou o processo de consolidação óssea.
Abstract: Literature shows that bone repair response can be accented by physical, mechanic or electromagnetic stimulation. There are evidences that low power ultrasound - US - can speed up bone regeneration. This work aimed at determining the effect of US in bone defects, experimentally created, in tibia from rats under load absence (suspended by the tail) by densitometric analysis and biomechanics. Thirty Rattus novergicus albinus, Wistar, adult, divided in 3 groups: G1 (n=10), not suspended - a 15 day experiment; G2 (n=10), suspended by the tail - a 15 day experiment and, G3 (n=10), suspended by the tail - a 36 day experiment. , The animals have been submitted to the osteotomy in both tibias and to the US application (1,5 MHz frequency, cycle 1:4, 30mW/cm2), on the right (twelve sessions of 20 minutes). G3 was only osteotomized after the 21st day of suspension. DPX-Lunar™ densitometer, Digora digital system and Image J computer program were used for densitometrical analysis; for the mechanical assay, the universal machine of EMIC assay was used. The results for Bone Mineral Content (g), Area (cm²), Bone Mineral Density (g/cm²) and Bone Density (mmAl) observed in tibias, as well as Maximum Power (N), and Rigidity (x103N/m) did not show any significant differences (treated versus control of each group), possibly due to shorter treatment time as regards the studies found in literature. Concluding that the low power ultrasound not accelerated the process of consolidating bone.
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Books on the topic "Bone Diseases, Metabolic – physiopathology"

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1948-, Regling Günter, ed. Wolff's law and connective tissue regulation: Modern interdisciplinary comments on Wolff's law of connective tissue regulation and rational understanding of common clinical problems. Berlin: W. de Gruyter, 1992.

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Allgrove, Jeremy, and Nick Shaw. Calcium and bone disorders in children and adolescents. 2nd ed. Basel: Karger, 2015.

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Jeremy, Allgrove, and Shaw Nick, eds. Calcium and bone disorders in children and adolescents. Basel: Karger, 2009.

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Camacho, Pauline M., ed. Metabolic Bone Diseases. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-03694-2.

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Paul, Grech, ed. Diagnosis of metabolic bone disease. London: Chapman and Hall Medical, 1985.

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C, Nordin B. E., Need A. G, and Morris H. A, eds. Metabolic bone and stone disease. 3rd ed. Edinburgh: Churchill Livingstone, 1993.

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Salvador, Castells, and Finberg Laurence, eds. Metabolic bone disease in children. New York: M. Dekker, 1990.

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S, Tam Cherk, Heersche Johannes N. M, and Murray Timothy M, eds. Metabolic bone disease: Cellular and tissue mechanisms. Boca Raton, Fla: CRC Press, 1988.

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C, Stevenson John, ed. New techniques in metabolic bone disease. London: Wright, 1990.

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W, Weissman Barbara N., ed. Imaging of arthritis and metabolic bone disease. Philadelphia, PA: Mosby/Elsevier, 2009.

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Book chapters on the topic "Bone Diseases, Metabolic – physiopathology"

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Adams, J. E. "Metabolic Bone Disease." In Musculoskeletal Diseases, 89–105. Milano: Springer Milan, 2005. http://dx.doi.org/10.1007/88-470-0339-3_14.

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Adler, Claus-Peter. "Metabolic and Storage Diseases." In Bone Diseases, 183–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04088-1_9.

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Bahk, Yong Whee. "Metabolic Bone Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 163–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-662-06294-4_13.

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Thijn, Cornelis J. P. "Metabolic Bone Diseases." In Radiology of the Hand, 147–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-50966-7_6.

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Botton, Miguel, António Robalo Correia, and Manuel Cassiano Neves. "Metabolic Bone Diseases." In General Orthopaedics and Basic Science, 73–82. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-92193-8_10.

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Bahk, Yong-Whee. "Metabolic Bone Diseases." In Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, 189–95. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-04106-2_13.

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Aithal, Hari Prasad, Amar Pal, Prakash Kinjavdekar, and Abhijit M. Pawde. "Metabolic Bone Diseases." In Textbook of Veterinary Orthopaedic Surgery, 327–51. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-2575-9_9.

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van Daele, P. L. A., and M. C. Zillikens. "Metabolic bone diseases." In Orthopaedics and Traumatology, 335–47. Houten: Bohn Stafleu van Loghum, 2021. http://dx.doi.org/10.1007/978-90-368-2638-9_22.

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Vande Berg, Bruno, Frederic Lecouvet, Paolo Simoni, and Jacques Malghem. "Metabolic Bone Diseases." In Musculoskeletal Diseases 2009–2012, 94–103. Milano: Springer Milan, 2009. http://dx.doi.org/10.1007/978-88-470-1378-0_16.

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Jasim, Sina, Robert Wermers, and Daniel L. Hurley. "Sclerotic Bone Disorders." In Metabolic Bone Diseases, 169–82. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-03694-2_12.

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Conference papers on the topic "Bone Diseases, Metabolic – physiopathology"

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Navada, Dinesh K. R., Ganesh S, and Bhargavi K. "A High Precision Deep-CNN Framework for Classification of Metabolic Bone Diseases Among Women." In 2018 3rd International Conference on Communication and Electronics Systems (ICCES). IEEE, 2018. http://dx.doi.org/10.1109/cesys.2018.8724013.

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Cox, L. G. E., C. C. van Donkelaar, B. van Rietbergen, and K. Ito. "Mechanoregulated Bone Remodeling May Explain Bone Structural Changes Observed in Osteoarthritis." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19583.

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Osteoarthritis (OA) affects both the articular cartilage and the subchondral bone. It is a complicated disease, associated with conditions varying from obesity and strenuous exercise to joint malalignment, anterior cruciate ligament (ACL) injury, and even metabolic bone diseases. Patients suffer from chronic joint pain and limitation of motion, and no cure is yet available. For many years, medical therapies have been focused on cartilage, because bone changes were thought not to play a major role in the OA disease process. However, it has been shown that bone changes occur in an early stage of OA, and that alterations to subchondral bone can lead to cartilage degeneration [1]. Therefore, currently the bone is considered as a therapeutic target as well.
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Penninger, Charles L., Neal M. Patel, and Andrés Tovar. "A Novel HCA Framework for Simulating the Cellular Mechanisms of Bone Remodeling." In ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/detc2012-70613.

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Each year, bone metabolic diseases affect millions of people of all ages, genders, and races. Common diseases such as osteopenia and osteoporosis result from the disruption of the bone remodeling process and can place an individual at a serious fracture risk. Bone remodeling is the complex process by which old bone is replaced with new tissue. This process occurs continuously in the body and is carried out by bone cells that are regulated by numerous metabolic and mechanical factors. The remodeling process provides for various functions such as adaptation to mechanical loading, damage repair, and mineral homeostasis. An improved understanding of this process is necessary to identify patients at risk of bone disease and to assess appropriate treatment protocols. High-fidelity computer models are needed to understand the complex interaction of all parameters involved in bone remodeling. The primary focus of this investigation is to present a new computational framework that utilizes mathematical rules to mechanistically model the cellular mechanisms involved in the bone remodeling process. The computational framework used in this research combines accepted biological principles, cellular-level rules in a cellular automaton framework, and finite-element analysis. This computational model is referred to as hybrid cellular automaton (HCA) model. The simulations obtained with the HCA model allow to predict time-dependent morphology variations at the tissue level as a result of biological changes at the cellular level.
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Takai, Erica, Clark T. Hung, Aurea Tucay, Djordje Djukic, Mary L. Linde, Kevin D. Costa, James T. Yardley, and X. Edward Guo. "Design of a Microfluidic System for 3D Culture of Osteocytes In Vitro." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33229.

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Bone adapts to its mechanical environment so that its form follows function, a mechanism known as Wolff’s law, or bone adaptation. Although the basic concepts of Wolff’s law have been generally accepted, the regulatory signals and the underlying cellular and molecular pathways, which mediate this adaptive process, are unknown. Failure of normal bone adaptation plays a significant role in the etiology of metabolic bone diseases such as osteoporosis and osteopetrosis, bone loss in space flight and failure of total joint replacements. During the past three decades, there have been extensive in vitro studies addressing mechano-signal transduction mechanisms in bone cells including osteoblasts, osteocytes, and osteoclasts [1–8].
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Tseng, Wei-Ju, Hainan Zhu, Beom Kang Huh, Chantal de Bakker, Shiming Luo, Juyu Tang, Ling Qin, and X. Sherry Liu. "Assessment of the Vascular and Trabecular Microstructures Using Micro Computed Tomography, Vascular Network Perfusion, and Image Registration Techniques." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14699.

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Bone is a dynamic organ that constantly undergoes remodeling throughout one’s life. The remodeling process is required to repair damaged bone tissue and more importantly, to regulate calcium and phosphate homeostasis through the osteocytic network in conjunction with the microvascular network within bone marrow. Recently, techniques combining micro computed tomography (μCT) imaging with vascular network perfusion were developed to allow for 3-D visualization of the bone vascular network structure [1]. However, simultaneous visualization of the trabecular and vascular microstructures using standard μCT remains challenging, and thus the precise relationships between blood vessel formation and trabecular remodeling, as well as the impact of these relationships on metabolic bone diseases such as osteoporosis, remain unclear.
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Holdstein, Y., and A. Fischer. "Modeling Micro-Scaffold-Based Implants for Bone Tissue Engineering." In ASME 2008 9th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2008. http://dx.doi.org/10.1115/esda2008-59034.

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Metabolic bone diseases are at the forefront of scientific and biomedical research worldwide. Diseases such as osteoporosis are characterized by increased bone fragility, which leads to micro-architectural deterioration of bone tissue and eventually to micro fractures. At the micro-structural level, bone is constructed from thin rods known as trabeculae and plates. These rods and plates are arranged in semi-regular, three-dimensional patterns and constitute highly anisotropic and heterogenic material. The bone micro-structure is stochastic in nature and varies according to patient, bone type and location within a specific bone. Diagnostic abilities rely on high technology and advanced methods for 3D micro scanning, modeling and analyzing the bone micro-structure. We propose a novel method for modeling scaffold-based implants that have the stochastic structure of bone and can be customized according to given bone structures. The method for designing these implants is based on a 3D pattern synthesis technique that can be applied to the diseased cavities of a given bone. The implants will replace these cavities in the cancellous bone. Recognizing these cavities is a difficult process, since such bone is characterized by a complex micro-structure composed of thin cylindrical rods and plates. Cavities with this 3D micro-structure will be identified by measuring the volumes of those cavities and comparing them to a specified threshold. The in-filling will be based on a 3D pattern growing scheme that takes the exerted forces into account so that the global directionality of the micro-structure is preserved. Furthermore, the goal is to optimize the topology according to mechanical rules. Due to the complexity of the problem, the approach is initially examined only for 2D medical images. The main contribution of this method is that the structure of the micro-implants will not be the current standard structure (cubes with holes), which lack the characteristics of a given bone structure. Moreover, this method can be used to design and manufacture customized micro-implants according to the specific stochastic micro-structure of a given bone. These customized designed implants can be manufactured using micro-RP technology.
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Zahirović, Nedim, Bojan Toholj, Marko Cincović, Ozren Smolec, and Mimi Ristevski. "Lameness in heifers: Integration of biological, metabolic and production characteristics and environmental factors as predisposing for the occurence of lameness." In Zbornik radova 26. medunarodni kongres Mediteranske federacije za zdravlje i produkciju preživara - FeMeSPRum. Poljoprivredni fakultet Novi Sad, 2024. http://dx.doi.org/10.5937/femesprumns24040z.

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The importance of lameness in heifers has been recognized more and more recently, so the thesis that "lameness in cows is a disease that starts in heifers" has been presented. In his work, he states that the occurrence of chromosotis in heifers predisposes them later to more frequent occurrence of acropodium diseases that can lead to lameness. Early detection of lameness, or even better, early detection of predisposing factors in heifers, could be of great importance in better understanding the problem of lameness in cattle. The corium of the hoof that is damaged by some disease loses its primary characteristics, and above all the property of relieving pressure, therefore the changes that occur due to diseases that lead to lameness, make cattle more susceptible to lameness in the future. Permanent changes on the palpebral bone have also been described, which lead to increased pressure on the corium and more frequent lameness. Practically, lameness is a risk factor for the recurrence of lameness. This is especially important in heifers because if lameness occurs in the early phase of life, then episodes of lameness will be more frequent in the rest of the period. The goal of the research is to examine the influence of clinical, morphological, biochemical and hematological parameters in heifers during the period of growth and development on the possibility of predicting the occurrence of lameness after calving.
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Yadykina, T. K., N. N. Mikhailova, and A. G. Zhukova. "BIOMEDICAL ASPECTS OF THE FORMATION OF METABOLIC MALADAPTATION IN CHRONIC OCCUPATIONAL INTOXICATION WITH FLUORIDE COMPOUNDS." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-535-539.

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Long-term exposure to fluorides on the body of aluminum production workers is a determining factor in the development of chronic occupational intoxication with fluorine compounds, the pathogenetic mechanisms of which have not been studied enough. The systemic aspects of its course remain open. The aim — on the basis of experimental and clinical genetic data to study the medical and biological aspects of the formation of metabolic maladaptation in the dynamics of fluoride intoxication. Material and methods. The study included 370 metallurgists with occupational pathology and a comparison group, n=127, with individual signs of fluorine exposure to the skeleton. Bone mineral density was studied. Real-time PCR evaluated the association of VEGF and GST gene polymorphisms with the risk of developing intoxication, diseases of the circulatory system, liver pathology, and renal dysfunction. The experiment was simulated with 12 weeks of free access of rats, n=130, to NaF solution, 10 mg/l. Western-blot analysis in the cytosolic fraction of the liver, kidneys, heart studied the level of HIF‑1α, HSP72, HSC73, HOx‑1,2. In the blood plasma and homogenate of the studied organs, the activity of metabolic enzymes was determined: alkaline and acid phosphatases, α-glycerophosphate dehydrogenases, alanine-, aspartate aminotransferases, cholinesterases, γ-glutamyltranspeptidase, catalase, superoxide dismutase lactate-, hydroxybutyratedehydrogenases. Results. A clinical and experimental study showed the development of specific metabolic changes in the dynamics of fluoride intoxication and their relationship with degenerative-dystrophic changes in the skeleton. The association of the GC VEGF, GSTT1, M1 0/0 genotype with the risk of developing comorbid pathology was determined. The experiment shows that the response to NaF develops in waves. In the early stages, the expression of protective proteins and metabolic enzymes in hepatocytes increases. Compensatory reactions are provided by increased cytochemical activity. From the 6th week, the structure of the liver and kidneys is disturbed. In the heart of rats, activation of the redox signaling system and antioxidant protection was noted, which reduces the intensity of free radical processes and preserves the structure of the myocardium up to the 3rd week. Further, the imbalance of compensatory mechanisms is determined against the background of activation of free radical oxidation, degenerative changes in cardiomyocytes, 9 weeks. Conclusions. The leading pathogenetic link in the formation of a chain of systemic pathological reactions in fluoride intoxication is maladaptive shifts in homeostasis parameters associated with individual risk.
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Lima, Rodrigo Quevedo de, Eimi Nascimento Pacheco, Luiz Henrique Santana de Araujo, Cassio Fernando Paganini, and Katsuki Arima Tiscoski. "PLASMOBLASTIC LYMPHOMA WITH MAMMARY MANIFESTATION: A CASE REPORT." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1085.

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Introduction: Plasmoblastic lymphoma (PBL) is a rare entity of non-Hodking lymphoma that usually occurs in the oral cavity in immunosuppressed patients. The involvement of other organs has rarely been reported. The breast can be the site of the initial manifestation of many diseases and in cases like this report, lymphomas should be considered as differential diagnoses. Case report: D.S., female, 28 years old, quality reviewer, married, two children. Carrier of human immunodeficiency virus (HIV) with recent treatment. Intern for investigation of liver, duodenal and breast abnormalities. She had nodules in both breasts, with progressive growth for about two months, in addition she presente nausea, vomiting, episodes of diarrhea and weight loss. On physical examination of the breasts, presence of apparent vascularization and asymmetric breast – right breast about two times the size of the contralateral. On palpation, the right breast presented with multiple hard and mobile nodules in a single left nodulation in an inferolateral quadrant measuring about 4 cm, with the same characteristics as the previous ones. No axillary lymph node enlargement, supraclavicular or infraclavicular fossae were noticed. Core biopsy was performed on both breasts with the result of undifferentiated malignancy, with a diffuse standard and numerous foci of apoptosis (compatible with high-grade non-Hodgkin’s lymphoma). In the immunohistochemical study, there was positivity for LCA, MUM 1, CD10, EMA, CMYC, CD30, CD3 and Ki-67 with a proliferative índex of 95% in neoplasia. Histopathological aspects and immunohistochemical profile were compatible with plasmoblastic lymphoma. During hospitalization, the patient underwent a myelogram that showed slightly hypercellular bone marrow, hematopoiesis was present and was megaloblastic. There was moderate diffuse and a focal irregular infiltration by pleomorphic and dysmorphic plasma cells, suggesting spinal cord involvement by plasmoblastic lymphoma. In addition, oncological PET/CT was performed which showed a metabolic increase in nodular formations in the right breast and thickening of gastroduodenal transition compatible with the clinical information of lymphoproliferative disease. The patient underwent six cycles of the EPOCH polychemotherapy scheme (etoposide, prednisone, oncovinm, cyclophosphamide and ydroxideunorubicin), associated with four cycles of methotrexate at high doses, with remission of breast lesions and is currently being followed up.
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