Relevant bibliographies by topics / Bone cancers in children and adolescents

Academic literature on the topic 'Bone cancers in children and adolescents'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Bone cancers in children and adolescents.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Bone cancers in children and adolescents"

1

Badar, Farhana, and Shahid Mahmood. "Epidemiology of cancers in Lahore, Pakistan, among children, adolescents and adults, 2010–2012: a cross-sectional study part 2." BMJ Open 7, no. 12 (December 2017): e016559. http://dx.doi.org/10.1136/bmjopen-2017-016559.

Full text
Abstract:
ObjectivesTo estimate the cancer incidence by age group for the Lahore district population within the Punjab Cancer Registry (PCR), Pakistan. The average annual population of Lahore was 9.8 million in 2010–2012. This is a sequel to a study published earlier.DesignA cross-sectional study.SettingThe registry has 19 centres in Lahore reporting their data to the coordinating office located within the Shaukat Khanum Memorial Cancer Hospital and Research Center (SKMCH&RC), Lahore, Pakistan.ParticipantsData existing in the PCR database, based on a confirmed diagnosis of cancer from 1 January 2010 to 31 December 2012, among the Lahore residents, were reviewed.Outcome measuresCancer counts and the age-standardised incidence rates (ASIR) per 100 000 population were computed by gender, cancer site/type and age group (0–14, 15–19 and ≥20 years).ResultsBetween 2010 and 2012, of the 15 840 new cancers diagnosed, 57% were in females. The ASIRs in age groups 0–14, 15–19 and ≥20 years, among females, were: 6.1, 8.4 and 170.7, respectively, and among males, 9.3, 12.2 and 104.5, respectively. The common diagnoses in children, adolescents and adults were: (1) among females: leukaemia: 2.2; bone tumour: 1.4 and breast cancer: 79.2, respectively, and (2) among males: leukaemia: 3.6; bone tumour: 2.4 and prostate cancer: 10.7, respectively.ConclusionsThe ASIR was higher in adult women than in men, but it was lower in girls and young women than their corresponding male counterparts. Leukaemia was the most common diagnosis in children and bone tumour in adolescents, regardless of gender. Among women, breast cancer and, in men, prostate cancer, were the leading cancer types, in adults. These estimates could be used for the expansion of health coverage in the region including setting-up low cost, diagnostic tests for early detection of cancers.
APA, Harvard, Vancouver, ISO, and other styles
2

Martinez-Rodriguez, Cesar, and Ma del Rocio Banos-Lara. "HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients." Pathogens 9, no. 1 (January 10, 2020): 51. http://dx.doi.org/10.3390/pathogens9010051.

Full text
Abstract:
Cancer is the first cause of death by disease in childhood globally. The most frequent types of cancers in children and adolescents are leukemias, followed by brain and central nervous system tumors and lymphomas. The recovery rate of cancer in children is around 80% in developed countries and up to 30% in developing countries. Some of the main causes of complications in children and adolescents with cancer are respiratory viral infections, mainly in bone marrow-transplanted patients. Respiratory viruses have been detected in the bronchoalveolar lavage or nasal wash specimens from cancer patients with or without respiratory illness symptoms. Human metapneumovirus (HMPV) is within the ten most common viruses that are encountered in samples from pediatric patients with underlying oncology conditions. In most of cases, HMPV is found as the only viral agent, but co-infection with other viruses or with bacterial agents has also been reported. The discrepancies between the most prevalent viral agents may be due to the different populations studied or the range of viral agents tested. Some of the cases of infection with HMPV in cancer patients have been fatal, especially in those who have received a hematopoietic stem cell transplant. This review seeks to show a general view of the participation of HMPV in respiratory illness as a complication of cancer in childhood and adolescence.
APA, Harvard, Vancouver, ISO, and other styles
3

Małek, Anna, Olga Wysokińska, Klara Iwaniszyn-Zapołoch, Karolina Zadrożna, Piotr Sidorczuk, Mateusz Fabiś, Bartłomiej Wójcik, Justyna Żyga, and Katarzyna Klajda. "Diagnosis of malignant bone tumors in children." Journal of Education, Health and Sport 12, no. 11 (November 8, 2022): 334–40. http://dx.doi.org/10.12775/jehs.2022.12.11.044.

Full text
Abstract:
Bone cancers occur mainly in adolescents and young adults, and benign lesions are more frequent than malignant ones. The most common malignant tumors include osteosarcoma, Ewing's sarcoma and chondrosarcoma. The course of the disease may not be obvious and symptoms may be ambiguous, so it is important to catch them early and take appropriate action. Laboratory tests such as CRP, ESR, LDH, ALP may prove useful in the diagnosis of bone neoplasms in children. All children with suspected malignant bone cancer should undergo an x-ray examination. MRI, CT scans are performed to expand the diagnosis and determine the extent of the disease. The basis of diagnosis is histopathological examination. The result of this study is very important in the selection of therapeutic procedures, it influences decisions regarding the scope and degree of radicality of the operation. It is crucial that the entire diagnostic process is carried out in highly specialized centers that have extensive experience in the diagnosis and treatment of malignant bone tumors in children. It is most beneficial to conduct diagnosis and treatment at the same center, and preferably by the same team of specialists. This team should include doctors from orthopedics, radiology, oncology, radiation therapy and pathomorphology. Conducting diagnosis and treatment in highly specialized centers has a positive effect on the prognosis and quality of life of patients. The purpose of this article is to highlight the early and uncharacteristic symptoms of bone cancer in children and to present the complexity of the diagnostic process, as well as the importance of carrying it out in highly specialized centers with extensive experience in treating pediatric bone malignancies.
APA, Harvard, Vancouver, ISO, and other styles
4

Close, Allison, Brittani Seynnaeve, Kimberly Miller, and Louis Rapkin. "Sex-specific mortality trends in adolescents and young adults with cancer from 2007 to 2016." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 1570. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.1570.

Full text
Abstract:
1570 Background: Adolescents and young adults (AYA) aged 15-39 years make up approximately 70,000 new oncology cases in the USA. Historically, mortality from cancer has smaller incremental improvements in AYA patients when compared to children and older adults, and not much is known about current sex-specific trends. We assessed overall and sex specific AYA mortality for the last 10 years (2007-2016). Methods: Trends in age-adjusted mortality rates per 100,000 (1972-2016) were obtained from the CDC’s National Center for Health Statistics (NCHS). Average annual percent changes (AAPCs) in relative survival were analyzed using NCI’s JPSurv webtool and mortality AAPCs were quantified using Joinpoint regression analysis. Results: Overall declines in mortality are similar in AYA men and women from 1972-2016, with 54% and 51% decline, respectively. In the most recent 10 years of data (2007 to 2016), combined sex AYA mortality AAPC’s declined by about 0.8% per year, slightly slower than declines in children <15 years (1.3% per year) and adults ages >40 years (1.5% per year). Among AYA males there have been 10 year AAPC mortality declines in leukemia (-1.8%), Hodgkin lymphoma (HL) (-5.1%), Non-Hodgkin lymphoma (NHL) (-4.1%) and melanoma of the skin (-3.4%). For AYA females, 10 year AAPC mortality declines occurred in leukemia (-1.9%), ovarian (-1.5%), HL (-10%), NHL (-4.9%) and melanoma (-2.8%). These declines have been offset by stable or increasing mortality rates for several common AYA cancers, including colorectal cancer (CRC) (1.1%) and bone and joint cancer (0.6%) in AYA males. AYA females have experienced mortality increases for CRC (0.6%), bone and joint cancer (0.5%) and uterine corpus cancer (2.8%). Conclusions: In general, mortality rates for both AYA men and women have declined over the past 10 years due to decreased mortality in hematologic malignancies and melanoma. Despite overall improvement, tumor categories in both AYA males and female such as CRC, bone and joint cancer, and uterine corpus cancers show increasing mortality. These diseases require specific investigations by both pediatric and adult researchers.
APA, Harvard, Vancouver, ISO, and other styles
5

Badar, Farhana, and Shahid Mahmood. "Cancer in Lahore, Pakistan, 2010–2019: an incidence study." BMJ Open 11, no. 8 (August 2021): e047049. http://dx.doi.org/10.1136/bmjopen-2020-047049.

Full text
Abstract:
ObjectivesTo study the cancer incidence rates over 10 years (2010–2019), in Lahore, Pakistan.DesignAn incidence study.SettingThe population-based Punjab Cancer Registry was established in 2005 in Lahore, which is the provincial metropolis of the province of Punjab (five rivers), and is located in the northeast region of Pakistan. The coordinating office of the Registry is located within Shaukat Khanum Memorial Cancer Hospital and Research Center. Both the active and passive forms of data collection are used.ParticipantsResidents of the district of Lahore diagnosed with cancer. The average annual population of Lahore was estimated at 11.1 million.Outcome measuresCancer counts and incidence rates per 100 000 population, by age-group, sex and cancer site/type, over 10 years.ResultsIn Lahore, from 2010 to 2019, 58 394 incident cases were reported, with the majority seen in females (57.1%). Adults accounted for 92.2%, adolescents 2.2% and children 5.6% of the total cases. Per 100 000 population, the age-standardised incidence rate was 103.4 for females and 65.6 for males. Among females, the highest incidence rates were recorded for breast cancer (76.7) in adults, bone tumour (1.2) in adolescents and lymphoid leukaemia (1.6) in children, and among males, prostate cancer (10.7) in adults, bone tumour (2.2) in young adults and lymphoid leukaemia (2.4) in children. The age-specific incidence rates peaked in the 60–70 year group, reaching a high of 420 per 100 000 in women and 330 per 1 00 000 men.ConclusionsIn Lahore, the incidence rates for cancers of the breast, prostate, lymphoid leukaemia and bone were among the highest documented. More cases were recorded in females than in males. The results reported could be used as a reference point for assessing the effectiveness of future interventions.
APA, Harvard, Vancouver, ISO, and other styles
6

Brion, Régis, Laura Regnier, Mathilde Mullard, Jérome Amiaud, Françoise Rédini, and Franck Verrecchia. "LIM Kinases in Osteosarcoma Development." Cells 10, no. 12 (December 15, 2021): 3542. http://dx.doi.org/10.3390/cells10123542.

Full text
Abstract:
Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research and clinical advances during the past decades, bone cancers remain a leading cause of death worldwide among paediatric cancer patients. Osteosarcomas are the most common malignant bone tumours in children and adolescents. Notwithstanding advances in therapeutic treatments, many patients succumb to these diseases. In particular, less than 30% of patients who demonstrate metastases at diagnosis or are poor responders to chemotherapy survive 5 years after initial diagnosis. LIM kinases (LIMKs), comprising LIMK1 and LIMK2, are common downstream effectors of several signalization pathways, and function as a signalling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. In recent decades, several reports have indicated that the functions of LIMKs are mainly implicated in the regulation of actin microfilament and the control of microtubule dynamics. Previous studies have thus identified LIMKs as cancer-promoting regulators in multiple organ cancers, such as breast cancer or prostate cancer. This review updates the current understanding of LIMK involvement in osteosarcoma progression.
APA, Harvard, Vancouver, ISO, and other styles
7

Jin, Hye Young, and Jun Ah Lee. "Low bone mineral density in children and adolescents with cancer." Annals of Pediatric Endocrinology & Metabolism 25, no. 3 (September 30, 2020): 137–44. http://dx.doi.org/10.6065/apem.2040060.030.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Taskinen, Mervi, Ulla M. Saarinen-Pihkala, Liisa Hovi, Kim Vettenranta, and Outi Mäkitie. "Bone health in children and adolescents after allogeneic stem cell transplantation." Cancer 110, no. 2 (2007): 442–51. http://dx.doi.org/10.1002/cncr.22796.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Mostoufi-Moab, Sogol, and Leanne M. Ward. "Skeletal Morbidity in Children and Adolescents during and following Cancer Therapy." Hormone Research in Paediatrics 91, no. 2 (November 27, 2018): 137–51. http://dx.doi.org/10.1159/000494809.

Full text
Abstract:
Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors.
APA, Harvard, Vancouver, ISO, and other styles
10

Metayer, Catherine, Charles F. Lynch, E. Aileen Clarke, Bengt Glimelius, Hans Storm, Eero Pukkala, Timo Joensuu, et al. "Second Cancers Among Long-Term Survivors of Hodgkin’s Disease Diagnosed in Childhood and Adolescence." Journal of Clinical Oncology 18, no. 12 (June 12, 2000): 2435–43. http://dx.doi.org/10.1200/jco.2000.18.12.2435.

Full text
Abstract:
PURPOSE: To quantify the risk of second cancers among long-term survivors of Hodgkin’s disease (HD) diagnosed before 21 years of age and to explore sex-, age-, and site-related differences. PATIENTS AND METHODS: We analyzed data from 5,925 pediatric HD patients, including 2,646 10-year and 755 20-year survivors, who were reported to 16 population-based cancer registries in North America and Europe between 1935 and 1994. RESULTS: A total of 157 solid tumors (observed/expected ratio [O/E] = 7.0; 95% confidence interval [CI], 5.9 to 8.2.) and 26 acute leukemias (O/E = 27.4; 95% CI, 17.9 to 40.2) were reported. Risk of solid tumors remained significantly increased among 20-year survivors (O/E = 6.6, observed [O] = 40, cumulative risk = 6.5%) and persisted for 25 years (O/E = 4.6, O = 15, cumulative risk = 11.7%). Temporal trends for cancers of thyroid, female breast, bone/connective tissue, stomach, and esophagus were consistent with the late effects of radiotherapy. Greater than 50-fold increased risks were observed for tumors of the thyroid and respiratory tract (one lung and one pleura) among children treated before age 10. At older ages (10 to 16 years), the largest number of second cancers occurred in the digestive tract (O/E = 19.3) and breast (O/E = 22.9). Risk of solid tumors increased with decreasing age at HD on a relative but not absolute scale. CONCLUSION: Children and adolescents treated for HD experience significantly increased risks of second cancers at various sites for 2 to 3 decades. Although our results reflect the late effects of past therapeutic modalities, they underscore the importance of lifelong follow-up of pediatric HD patients given early, more aggressive treatments.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Bone cancers in children and adolescents"

1

Riddell, Amy. "The muscle-bone in children and adolescents with and without cystic fibrosis." Thesis, University of Cambridge, 2016. https://www.repository.cam.ac.uk/handle/1810/268034.

Full text
Abstract:
Introduction: Puberty is a crucial period for rapid changes in bone mineral, size, geometry, and microarchitecture. The mechanostat theory postulates that increased mechanical loading will affect bone phenotype and strength during development and in later life. Individuals with cystic fibrosis (CF) have an increased risk of developing osteoporosis and fragility fractures in young adulthood, which may be caused by poor growth. The aim was to investigate whether sex and disease status modified the relationship between: 1) puberty and bone, and 2) muscle and bone. This would contribute to the understanding of how sex (males vs. females) and disease group (CF vs.controls) alters the relationship between bone and muscle in children and adolescents as they transition through puberty and who, on a population level, differ in the prevalence of osteoporosis and risk of fracture in later life. Methods and Analyses: This observational study used novel imaging and muscle assessment techniques to measure bone and muscle parameters in White Caucasian children and adolescents, aged 8 to 16 years, living in the UK, with children with CF (n=65) and controls (n=151). Anthropometry and pubertal status were assessed. Dual energy X-ray absorptiometry, peripheral quantitative computed tomography (pQCT), high-resolution pQCT, and jumping mechanography were used to measure bone and muscle outcomes. ANCOVA with Scheffé post hoc and multiple linear regression tests were performed. Data were adjusted according to the research aims and included covariates; sex, disease group, pubertal stage, age, quadratic age, height, weight, maximum force (Fmax), and maximum power (Pmax). Data are presented as beta-coefficient (%) and p-value, with the significance level set to p < 0.05. Results: In height adjusted analyses, among healthy participants, females had smaller bones and lower bone density compared to males. With pubertal maturation, females had lower apparent gains in the distal and proximal total area (Tt.Ar and CSA), distal cortical porosity (Ct.Po) and proximal bone strength (SSI) but higher apparent gains in distal and proximal cortical bone density(Ct.BMD, Ct.TMD, vBMD). Females had consistently lower distal total area (total CSA) and density (total vBMD), distal trabecular density(BV/TV) and number(Tb.N), and proximal cortical area(CSA) compared to males, across all stages of puberty. With increasing muscle force (Fmax), females had higher apparent gains in total body less head bone mineral (TBLH BMC) and bone area(BA), distal total and trabecular density (total and trab vBMD) compared to males. In contrast, with increasing muscle power (Pmax), females had higher apparent gains in distal total and cortical densities (D100, Ct.BMD and Ct.TMD), and distal trabecular thickness (Tb.Th), and proximal cortical density (cortical vBMD) but lower apparent gains in distal cortical porosity (Ct.Po) and trabecular number (Tb.N) compared to males. In height adjusted analyses, participants with CF had smaller bones and lower bone density compared to controls. With increasing pubertal maturation, participants with CF had lower apparent gains in total body less head bone mineral and bone area, and in distal trabecular density, cortical porosity, and trabecular thickness compared to controls. Participants with CF had consistently lower distal total and cortical area, distal total and trabecular densities and proximal bone strength compared to controls, across all stages of puberty. With increasing muscle force, participants with CF had lower apparent gains in total body less head bone mineral and bone area, distal total density, trabecular density, and trabecular number. In contrast, with increasing muscle power (Pmax), participants with CF had higher apparent gains in distal trabecular density (BV/TV) and trabecular number (Tb.N) compared to controls. Conclusion: These findings suggests that sex and disease status do modify the relationships between puberty and bone, and between muscle function and bone. Skeletal adaptation to muscle differs between sexes and in populations with chronic disease, which may explain sex and disease group differences in risks of osteoporosis and fracture. Bone adaptation to muscle in children with CF is altered, which may lead to narrow, under-mineralised bones, with lower bone strength in later life. Understanding better impairments in muscle functions may provide targets for intervention to improve skeletal health in later life.
APA, Harvard, Vancouver, ISO, and other styles
2

Kaovorakarn, Evelyn Amber. "The Effects of Vitamin C on Bone Development in Children and Adolescents." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579423.

Full text
Abstract:
Background: Numerous studies have focused on the contribution of calcium and vitamin D to bone growth and mass accumulation, but not many focused on other nutrients such as vitamin for promoting bone growth and mineralization. Objectives: 1) To determine whether dietary intakes of Vitamin C positively supports bone growth and increases the bone mineral density in both boys and girls. 2) To determine the effectiveness of fruits and vegetables for improving bone mineral density in adolescents. Search Methods: The search strategies included a search on PubMed.gov for studies from year 2000 to present that focused on the correlation between the vitamin C or fruits and vegetable intakes and the bone development.
APA, Harvard, Vancouver, ISO, and other styles
3

Buntain, Helen Mary. "Clinical aspects of bone mass accrual in children and adolescents with cystic fibrosis /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19505.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Hoy, Christa Leigh. "The influence of adiposity on bone quality in children, adolescents and young adults." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43098.

Full text
Abstract:
Introduction: Overweight children have greater bone mass than their healthy weight peers; however, they sustain more fractures. Thus, there is a need to better understand the relation between body fat and bone strength and aspects of bone quality such as bone microstructure that contribute to bone strength. Methods: I aimed to determine the cross-sectional relationship between fat mass (FM) and aspects of bone quality (strength, geometry, density and microstructure) at the distal radius and distal tibia in boys (n = 137, 15.6 ± 3.3 yrs on average) and girls (n = 157, 14.5 ± 3.9 yrs) in the context of the functional model of bone development (after adjusting for lean mass (LM)). FM and LM were measured using dual energy X-ray absorptiometry and bone quality was measured using high resolution-peripheral quantitative computed tomography. Results: In boys, FM negatively predicted bone strength at the radius but not at the tibia. Conversely, FM did not significantly predict bone strength in girls. In both boys and girls, FM negatively predicted total area at the radius but not the tibia. In girls but not boys, FM positively predicted cortical bone mineral density at the tibia but not the radius. For bone microstructure, FM did not significantly predict many variables; however, FM negatively predicted cortical thickness at the tibia in boys, trabecular thickness at the tibia in girls, and cortical porosity at both the radius and tibia in girls. In nearly all cases, LM mediated the relationship between FM and bone quality, whereby prior to adding LM to regression models FM positively predicted bone quality; however, after adjusting for LM the positive associations became non-significant or negative. Conclusions: The relation between fat and bone is complex and appears to be sex- and site-specific. My results also highlight the important influence of lean mass on bone strength. Longitudinal studies with larger cohorts and more overweight and obese participants would clarify the sex-specific muscle-fat-bone relationships during growth and into adulthood. The potentially hazardous influence of high levels of fat mass on child and youth bone health must be considered among the adverse consequences of overweight and obesity.
APA, Harvard, Vancouver, ISO, and other styles
5

Ahmid, Mahjouba A. E. "Bone health and body composition of children and adolescents with growth hormone deficiency." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7896/.

Full text
Abstract:
Childhood onset growth hormone deficiency (CO-GHD) may contribute to low bone mass and alterations to body composition. This thesis consists of a series of studies utilising dual-energy X-ray absorptiometry (DXA), peripheral quantitative computerized tomography (pQCT) and biochemical assessment of bone health and body composition of CO-GHD. In addition, metabolic profiles, glucose metabolism as well as quality of life have been studied in these subjects. Furthermore, an interventional study of weight bearing exercise (WBE) was performed to explore its role in influencing the bone health of children and adolescents with CO-GHD. Chapter 1, relevant literature reviews explore: bone structure, growth, development and strength; GH/IGF-1 system and its actions; CO-GHD and its impacts during childhood and transition; and WBE and its mechanism and impacts on bone health. Chapter 2 presents the rationale and specific aims of this thesis. Chapter 3, a retrospective multicentre review of management of young adults with CO-GHD in four paediatric centres in Scotland during transition. Medical records of 130 eligible CO-GHD adolescents (78 males), who attained final height between 2005-2013 were reviewed. Of the 130, 74/130(57%) had GH axis re-evaluation by stimulation tests /IGF-1 measurements. Of those, 61/74(82%) remained GHD with 51/74(69%) restarting adult rhGH. Predictors of persistent GHD included an organic hypothalamic-pituitary disorder and multiple pituitary hormone deficiencies (MPHD). Despite clinical guidelines, there was significant variation in the management of CO-GHD in young adulthood across Scotland. Chapter 4, a cross-sectional control study of bone DXA measurements in (n=21) subjects with CO-GHD treated with rhGH and had attained final height from 2005 to 2013 in a single tertiary paediatric centre compared to (n= 21) heights/age matched healthy controls. By applying different models of DXA adjustment, our analysis revealed lower TB-BMC for bone area in males with CO-GHD and lower LS-BMAD SDS in females with CO-GHD compared to matched controls. In addition, subjects with CO-GHD had lower LM for height and higher FM for height compared to controls, and this was more pronounced in males than females (p=0.04). The time of onset and aetiology of CO-GHD have a larger influence on accrual of bone mass in these patients. These findings indicate that adolescents with CO-GHD have a low bone mass, despite prior long term rhGH replacement therapy. In chapter 5, we investigated bone health of subjects with CO-GHD at time of initial evaluation and retesting at final height. A total of 25 children (first time assessment group) undergoing GH stimulation tests for investigation of short stature (naive GHD-15, normal-10), and 11adolescents with CO-GHD (retesting group) undergoing biochemical re-evaluation at final height after withdrawal of rhGH therapy (persistent GHD-7, GH-sufficient-4) were recruited from Royal Hospital for Children between 2012-2013. By using further bone health assessment methods in addition to DXA (including p.QCT, mechanography, bone profiles and biomarkers), the bone density and body composition did not differ when we compared GHD to matched height but normal GH at initial evaluation and retesting. However, naive GHD had lower muscle force as assessed by mechanography compared to the normal. In addition, bone resorption biomarker CTX was significantly higher in naive GHD vs. normal and that was significantly correlated to PTH levels in both first time assessment and retesting groups. Our results suggest that muscle force and serum PTH may be important determinants of bone health in subjects with CO-GHD. Chapter 6 investigates lipids, adipokines (leptin- adiponectin- resistin) and glucose homeostasis and their relationship with bone and body composition in children and adolescents with CO-GHD at times of initial evaluation and retesting at final height (same population as chapter 5). Lipid profiles, adipokines and glucose homeostasis were not different between those with GHD and those who had normal GH levels across the groups of first time assessment and retesting. In the retesting group, those who were older at the time of diagnosis of CO-GHD with a shorter duration of rhGH therapy were more likely to have higher cholesterol(r=0.9, p<0.001), leptin (r=0.8, p<0.001), and lower osteoclacin (r=-0.7, p=0.01) at final height. Leptin levels correlated positively with osteocalcin at diagnosis (r=0.51, p=0.01) but inversely at retesting (r=-0.91, p<0.01). The conclusion was that the timing and duration of childhood rhGH therapy might influence adiposity parameters and bone metabolism in subjects with CO-GHD. In chapter 7 the study participants of chapter 5 were asked to complete either Short Form-36 (SF-36) or Adult Growth Hormone Deficiency Assessment (AGHDA) quality of life (QoL) questionnaires at the time of assessment of their GH axis. Our analysis showed that the overall QoL was not altered in children with naive GHD with a total score of SF-36 [93 (77, 96) naive GHD vs. 90 (84, 93) normal, P=0.56] (higher scores reflect better QoL). However, naive GHD had less energy and vitality scores compared with normal (75 (65, 100) vs. 95 (65,100) respectively, p=0.04), when the normal scored lower in the subscale of emotional well-being compared to those with naive GHD (78 (55, 84) vs. 90 (68, 96) respectively, p<0.001). In the retesting group, those with persistent GHD scored better in the AGHDA than GH sufficient (6 points (2, 8) vs. 9 points (7, 17) respectively, though not significant (p= 0.10) (higher scores reflect poorer QoL). Unexpectedly, subscale analysis showed that GH-sufficient subjects significantly lacked energy and complained of tiredness compared to those who were confirmed to have persistent GHD (5 points (3, 6) vs. 1 point (0, 1) respectively, p= 0.03). Further studies to validate QoL specific instruments in this population are needed with greater insight to elucidate factors that modify the relationship between GH status and QoL in children and adolescents. Chapter 8 was a prospective intervention, randomised controlled study of 14 subjects among the first time assessment group (GHD-10, normal-4) and five subjects with CO-GHD among retesting group (persistent GHD-4, GH-sufficent-1). Subjects were randomised into either an exercise intervention group (EX) (25 jumps off 25 cm platform step/three days/week for six months) or a control, in addition to rhGH being prescribed. The results of this study were limited by the small sample size and poor compliance. Therefore, there were insufficient data to recommend the use of weight bearing exercise in the absence of rhGH in children and adolescents with CO-GHD. Further studies with adequate sample size that can more rigorously exam the optimal exercise interventions are needed. Chapter 9 discusses the main findings of each chapter in this thesis and outlines potential limitations of the thesis methodology, and some important and interesting areas for future research in children and adolescents with CO-GHD.
APA, Harvard, Vancouver, ISO, and other styles
6

Åström, Eva. "Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta (OI) : effects on clinical symptoms and bone turnover /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-347-4/.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Mather, Sandra Joan. "Ultrasound bone analysis in children and adolescents with anorexia nervosa and related eating disorders." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325694.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Soliman, Ashraf. "Study of growth and bone mineral density and factors affecting them in children and adolescents with thalassaemia major and sickle cell disease." Thesis, University of South Wales, 1998. https://pure.southwales.ac.uk/en/studentthesis/study-of-growth-and-bone-mineral-density-and-factors-affecting-them-in-children-and-adolescents-with-thalassaemia-major-and-sickle-cell-disease(9cd79851-b7a7-4df7-bb2d-65e71e48d6c4).html.

Full text
Abstract:
Thalassaemia and sickle cell disease (SCD) are the most widely distributed blood genetic disorders that occur at a high frequency in some populations including the Mediterranean region, parts of the Middle East, South East Asia and the Indian subcontinent. It is estimated that thalassaemia major affects 100,000 newborn every year world-wide. The high incidence of these chronic haemolytic diseases in developing countries poses a high load on the national economy because of the expensive treatment protocols and the considerably high morbidity rates of these patients. Repeated blood transfusion to keep haemoglobin above an acceptable level requires well-equipped blood banks with expensive facilities to screen, store and manipulate blood and blood products. Iron chelation therapy is an essential part of treatment to avoid or delay the deleterious effects of iron overload on different organs including the liver, heart, pancreas and endocrine glands. This inquires injecting deferoxamine subcutaneously for 12 hours daily with a special pump. Both deferoxamine and pumps are expensive and therefore not accessible for all patients. In developing countries, the majority of transfusion-dependent patients with chronic haemolytic anaemia (thalassaemia and SCD) suffer from the consequences of sub-optimal treatment. The mortality rate is still high and usually patients die before the age of 30 years. They also suffer from chronic multi-organ damage including cardiac failure, liver cirrhosis, insulin-dependent diabetes mellitus, growth and pubertal failure and many skeletal abnormalities and fractures. In developed countries the introduction of high transfusion regimes and efficient chelation therapy improved survival rates and prevented cardiac and hepatic damage. However, a majority of thalassaemic patients still have significant growth and pubertal abnormalities, bone disease and multiple endocrine disorders. In Egypt the incidence of thalassaemia major ranges between 0.1 - 0.2% which gives very high patient load on the medical services. In our University of Alexandria Children's Hospital, Alexandria, Egypt. The Haematology clinic has an average of 150 thalassaemic children registered. The same problem is encountered by me in the Royal Hospital, Muscat, Oman, with high prevalence of SCD and thalassaemia and suboptimal treatment. Because of the restricted economic resources, both hospitals adopt a low transfusion therapy (to keep haemoglobin above 9 g/dl) with IM chelation 3 times per week. With this form of sub-optimal treatment we observed that a large number of our thalassaemic children have severe growth and pubertal failure/delay, beside other hepatic, cardiac and skeletal abnormalities. In fact they constitute 40% of patients attending our Endocrinology clinic. This stimulated me to perform an extensive study to survey growth and pubertal development in theses patients (study-1) and investigate the different factors that might affect their growth and pubertal development (studies 4 through 10) a \veU as bone mass density (studies > 1,12). The frequent involvement of the liver in these patients led us to study some hepatic functions and the prevalence of transfusion-associated hepatitis B surface antigenaemia and hepatitis-C virus antibody scropositivity in relation to their linear growth (studies 2,3). We studied the nutritional intake of these patients, their intestinal absorption of D-Xylosc and 48-h stool fat content in relation to their body mass index, subcutaneous 'at thickness and mid-arm circumference (studies 4,5,9). Their defective linear growth urged us to investigate their growth hormone (GH) secretion (spontaneous nocturnal as well as after provocation) and insulin-like growth factor-I (IGF-I) and IGK-binding protein-3 (IGKBl'3) concentrations. Our findings demonstrated high prevalence of defective GH secretion in these children that necessitated imaging of their hypothalamic pituitary area. Imaging studies revealed original data about structural abnormalities in the anterior pituitary gland, different degrees of pituitary atrophy and empty sella and infiltration the gland as well as the mid-brain by hacniosidrin in thalassaemic children, the mechanism of these findings was explained (studies 4-6,10). Because of their slow growth, the presence of abnormal GH/IGF-I/BP3 axis, and structural abnormalities of the pituitary gland, the next step dealt with the response of IGF-I to exogenous GH and the clinical response of their linear growth to GH therapy for a year or more (studies 4,9). Based on the fact that these patients have high prevalence of bone pains and osteoporosis during late childhood and have high risk of spontaneous fracture thereafter, we measured their bone mass density to investigate the relation between the former and the degree of iron load, growth parameters, and different anabolic hormone concentrations in these patients (studies 11,12).
APA, Harvard, Vancouver, ISO, and other styles
9

Knechtli, Christopher John Cranstoun. "The application of minimal residual disease analysis in children and adolescents undergoing allogeneic bone marrow transplantation for acute lymphoblastic leukaemia." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297806.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Arora, Ramandeep. "A study of the aetiology and epidemiology of cancers in teenagers and young adults." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/a-study-of-the-aetiology-and-epidemiology-of-cancers-in-teenagers-and-young-adults(effc3dd6-6655-47cd-af95-6eb26cb055c8).html.

Full text
Abstract:
Introduction: Little is known about the aetiology of cancer in teenagers and young adults (TYA) aged 15-24 years, although in England, cancer is the most common cause of disease-related mortality in this age group. The most common cancers at this age are lymphomas, central nervous system (CNS) tumours and germ cell tumours (GCT). The commonest carcinomas seen at older ages including lung, breast, large bowel and prostate account for only 3-4% of TYA cancers. In this thesis I describe the incidence patterns of selected cancers in TYA and the variation seen with geography, time and in population subgroups. The focus is on CNS tumours, GCT and bone tumours as they either peak in incidence in TYA and/or contribute disproportionately to cancer related mortality in TYA. This will allow formulation of hypotheses regarding aetiology of cancer in this age group which can then be tested by further research. Methods: For the majority of the analysis, anonymised national cancer registration data from England on individual patients of all ages with newly diagnosed cancer between 1979 and 2003 were used. To contrast the incidence patterns in England with that of India, data from five Indian urban population based cancer registries were used for part of the analysis. Age, sex, site and histology specific incidence rates were calculated and expressed per million person years. All rates, where appropriate, were adjusted to the world standard population using direct methods. To explore the link of growth with development of osteosarcoma and Ewing sarcoma, a random-effects meta-analysis was undertaken on studies which investigated an association of these tumours with height at diagnosis. Results: The incidence of cancer in TYA overall in England exceeded that of India. This was also true for most individual sites including epithelial cancers of lung, colon/rectum, breast, ovary and cervix, and non-epithelial cancers including melanoma, Hodgkin lymphoma and testicular cancer. Notable exceptions to this pattern were cancers of the mouth, gall bladder and stomach (females only) where incidence was higher in India. In England, CNS tumours in TYA were a composite of pilocytic astrocytomas and embryonal tumours (representing tail end of childhood CNS tumours), pituitary tumours, nerve sheath tumours, high grade astrocytomas and meningiomas (representing early-onset of CNS tumours that peak in incidence in the 6th and 7th decade of life), and of CNS GCTs, pleomorphic xanthoastrocytomas and neurocytomas which show a peak incidence in TYA. Irrespective of site or histology, GCT in England showed a peak in incidence between ages of 10 to 39 years which was more marked in males. This however varied by site and the peak incidence was seen at 10 to 14 years in the CNS, 15 to 19 years in ovary, 25 to 29 in mediastinum & thorax and abdomen & pelvis, and 30 to 34 years in testicular tumours. Osteosarcoma and Ewing sarcoma were the predominant bone tumours in TYA in England and showed a distinct peak of incidence at 10 to 14 years age in females and a larger peak at 15 to 19 years age in males. The peak incidence of osteosarcoma of long bones of the lower limb was six times more than that at any other site while the peak incidence of Ewing sarcomas located in the bones of the central axis exceeded those in long bones of the lower limb. The average height of patients with osteosarcoma at diagnosis was found to be significantly above the average height of the reference population, at the 95% level. The association of greater height at diagnosis with Ewing sarcoma was also significant at the 95% level but much weaker. Conclusion: In this thesis I have explored the epidemiology of cancer in TYA using some of the established methodologies which have previously been used in advancing our knowledge of childhood and older adult cancers. These studies provide some clues to aetiology. Variation in environmental exposures and lifestyle factors between England and India can explain the majority of the differences in incidence patterns observed. Genetic predisposition to cancer along with carcinogen exposure could lead to early onset of some cancers generally seen in older adults. Regardless of site, the similarity in age-incidence patterns of GCT, suggests a common initiation of these tumours in embryonic/foetal life with variable rates of tumour progression as a result of local factors or events during postnatal and pubertal period. The incidence patterns of osteosarcoma along with the strong and consistent association with a greater height at diagnosis indicate that bone growth is important in the development of this tumour while different biological pathways which may be unrelated to growth could also be relevant for Ewing sarcoma.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Bone cancers in children and adolescents"

1

Allgrove, Jeremy, and Nick Shaw. Calcium and bone disorders in children and adolescents. 2nd ed. Basel: Karger, 2015.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Jeremy, Allgrove, and Shaw Nick, eds. Calcium and bone disorders in children and adolescents. Basel: Karger, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Arndt, Carola A. S., ed. Sarcomas of Bone and Soft Tissues in Children and Adolescents. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51160-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Picoult, Jodi. My sister's keeper: A novel. New York: Washington Square Press, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Picoult, Jodi. Ma vie pour la tienne. Paris: J'ai lu, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Picoult, Jodi. My sister's keeper. London: Hodder, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Picoult, Jodi. 姐姐的守护神. Haikou: Nan hai chu ban gong si, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Picoult, Jodi. Ma vie pour la tienne. Paris: Éd. France loisirs, 2005.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Picoult, Jodi. My sister's keeper: A novel. New York: Washington Square Press, 2005.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Picoult, Jodi. My sister's keeper. London: Hodder, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Bone cancers in children and adolescents"

1

Bartl, Reiner, and Christoph Bartl. "Osteoporosis in Children and Adolescents." In Bone Disorders, 271–79. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29182-6_40.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Martel, José, Silvia Martín, Ernesto Rivera, and Ángel Bueno. "Bone Fractures." In Sports Injuries in Children and Adolescents, 45–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54746-1_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Boyanov, Mihail A. "Bone Development in Children and Adolescents." In Puberty, 77–94. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32122-6_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Crofton, Patricia M. "Bone Metabolites." In Diagnostics of Endocrine Function in Children and Adolescents, 429–47. Basel: KARGER, 2011. http://dx.doi.org/10.1159/000327420.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Gilsanz, Vicente, and Osman Ratib. "Indicators of Skeletal Maturity in Children and Adolescents." In Hand Bone Age, 11–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23762-1_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Mertens, Ann C., and Thorsten Langer. "Rare Subsequent Primary Cancers in Pediatric Cancer Survivors." In Rare Tumors In Children and Adolescents, 529–36. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-04197-6_46.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Pitts, Sarah, and Catherine M. Gordon. "Indications for DXA in Children and Adolescents." In Bone Health Assessment in Pediatrics, 75–87. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30412-0_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Crabtree, Nicola J., and Kyla Kent. "Acquisition of DXA in Children and Adolescents." In Bone Health Assessment in Pediatrics, 89–114. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30412-0_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Fung, Ellen B. "Reporting DXA Results for Children and Adolescents." In Bone Health Assessment in Pediatrics, 135–49. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30412-0_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Grabowski, Peter. "Physiology of Bone." In Calcium and Bone Disorders in Children and Adolescents, 32–48. Basel: KARGER, 2009. http://dx.doi.org/10.1159/000223687.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Bone cancers in children and adolescents"

1

Choquehuanca, Maria E. Farfan, Jose Sulla-Torres, and Vanessa M. Huanca Hilachoque. "Detection of Bone Weakness in Children and Adolescents in High Andean Zones Using Data Mining Techniques." In 2022 10th International Conference on Information and Education Technology (ICIET). IEEE, 2022. http://dx.doi.org/10.1109/iciet55102.2022.9779016.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

O’Toole, CF, A. Bush, and SB Carr. "P8 Bone mineral density in children and adolescents with cystic fibrosis, should we be doing less monitoring?" In Royal College of Paediatrics and Child Health, Abstracts of the Annual Conference, 13–15 March 2018, SEC, Glasgow, Children First – Ethics, Morality and Advocacy in Childhood, The Journal of the Royal College of Paediatrics and Child Health. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2018. http://dx.doi.org/10.1136/archdischild-2018-rcpch.8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Fraga, Melissa Mariti, Filipe Pedroso de Sousa, Yhasmin Oliveira Godim, Ana Flavia da Silva Pina, Ana Paula Sakamoto, Marcelo de Medeiros Pinheiro, and Maria Teresa Terreri. "Trabecular Bone Score (TBS) and Bone Mineral Density (BMD) analysis by DXA (dual X‐ray absorptiometry) in healthy Brazilian children and adolescents: normative data." In XXXIX Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2022. http://dx.doi.org/10.47660/cbr.2022.1899.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Bone cancers in children and adolescents' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography