Relevant bibliographies by topics / Blood fatty acid

Academic literature on the topic 'Blood fatty acid'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Blood fatty acid"

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Wood, Jordan, Larry J. Minter, Michael K. Stoskopf, Doug Bibus, Dempsy Ange, Troy N. Tollefson, Vivek Fellner, and Kimberly Ange-van Heugten. "Investigation of Dried Blood Spot Cards for Fatty Acid Analysis Using Porcine Blood." Veterinary Medicine International 2021 (August 28, 2021): 1–4. http://dx.doi.org/10.1155/2021/6624751.

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Fatty acids, especially omega-3 and omega-6 fatty acids, are important for reproductive and cardiovascular health in animals. While monitoring fatty acids is traditionally conducted using frozen blood fractions such as serum and plasma, advancements in analytical technology have developed a method of collecting microsamples of dried whole blood on Ahlstrom 226 grade filter paper that can provide information on long-term fatty acid status of animals. Blood samples were collected from five male pigs in both the traditional frozen method and on dried blood spot cards (DBS). The DBS samples were collected with untreated syringes and tubes, and approximately 320 μL of blood was placed on each card with approximately 80 μL per spot (4 spots). Statistical analysis was performed to compare the two sample groups to each other using the Mann–Whitney U-test and determine if DBS samples were similar to traditional whole blood samples. Of the 30 fatty acids and fatty acid groups with measurable concentrations, only four individual fatty acids, behenic acid, omega-3 docosapentaenoic acid, nervonic acid, and adrenic acid, had statistical differences. Most of these differences were minor and could be due to analytical errors or contamination. Comparisons between sample types found similar concentrations of key omega fatty acids and PUFAs and support the use of DBS collection as a less invasive method of blood collection and fatty acid analysis.
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Wood, Jordan, Larry J. Minter, Doug Bibus, Michael K. Stoskopf, Vivek Fellner, and Kimberly Ange-van Heugten. "Comparison of African savanna elephant (Loxodonta africana) fatty acid profiles in whole blood, whole blood dried on blood spot cards, serum, and plasma." PeerJ 9 (December 14, 2021): e12650. http://dx.doi.org/10.7717/peerj.12650.

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Background African elephants in managed care have presented differences in the balance between omega-3 and omega-6 fatty acids, a situation primarily thought to be due to dietary differences between the managed animals and their free-ranging counterparts. Because of this, circulating fatty acid status is included in routine monitoring of elephant health. A method of blood collection that requires only a few drops of whole blood, dried on filter paper (DBS) and can be used for analyzing full fatty acid profiles offers advantages in clinical application. Methods This study compared the use of whole blood, and whole blood DBS, serum or plasma for use in evaluating circulating fatty acid composition in African savannah elephants. Samples from six African elephants (two males and four females) were collected during the same week at the NC Zoo, Asheboro, NC. Results Results found only 2 of 36 individual fatty acids and none of the 10 fatty acid groupings were different when comparing the four blood fraction sample types to each other with Mann-Whitney U-Test pairwise comparisons. Myristic acid (14:0) was lower in the DBS samples than in whole blood, serum, and plasma and pentadecaenoic acid (15:1) was slightly more concentrated in DBS and whole blood. Discussion Results indicate that fatty acid profile of serum, plasma, whole blood, and DBS are comparable in African elephants. The DBS method offers advantages in acquisition and handling and may be preferable to other methods in both routine health assessment of captive animals and field research on free ranging animals.
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Sergeant, Susan, Ingo Ruczinski, Priscilla Ivester, Tammy C. Lee, Timothy M. Morgan, Barbara J. Nicklas, Rasika A. Mathias, and Floyd H. Chilton. "Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans." British Journal of Nutrition 115, no. 2 (November 30, 2015): 251–61. http://dx.doi.org/10.1017/s0007114515004341.

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AbstractNumerous studies have examined relationships between disease biomarkers (such as blood lipids) and levels of circulating or cellular fatty acids. In such association studies, fatty acids have typically been expressed as the percentage of a particular fatty acid relative to the total fatty acids in a sample. Using two human cohorts, this study examined relationships between blood lipids (TAG, and LDL, HDL or total cholesterol) and circulating fatty acids expressed either as a percentage of total or as concentration in serum. The direction of the correlation between stearic acid, linoleic acid, dihomo-γ-linolenic acid, arachidonic acid and DHA and circulating TAG reversed when fatty acids were expressed as concentrationsv. a percentage of total. Similar reversals were observed for these fatty acids when examining their associations with the ratio of total cholesterol:HDL-cholesterol. This reversal pattern was replicated in serum samples from both human cohorts. The correlations between blood lipids and fatty acids expressed as a percentage of total could be mathematically modelled from the concentration data. These data reveal that the different methods of expressing fatty acids lead to dissimilar correlations between blood lipids and certain fatty acids. This study raises important questions about how such reversals in association patterns impact the interpretation of numerous association studies evaluating fatty acids and their relationships with disease biomarkers or risk.
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Van der Vusse, G. J., and T. H. Roemen. "Gradient of fatty acids from blood plasma to skeletal muscle in dogs." Journal of Applied Physiology 78, no. 5 (May 1, 1995): 1839–43. http://dx.doi.org/10.1152/jappl.1995.78.5.1839.

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In anesthetized dogs, the amount of fatty acyl moieties in the fatty acid, triacylglycerol, and phospholipid fractions of arterial blood and biceps femoris muscle has been determined to delineate the presence of a fatty acid gradient from blood to skeletal muscle tissue, if any. The content of fatty acids in biceps femoris muscle was found to be very low (approximately 0.1% of total amount of unesterified and esterified fatty acyl moieties in the tissue sample). The ratio of the content of fatty acids (nmol/ml) in arterial plasma and the tissue level of fatty acids (nmol/g wet weight) was approximately 17. This finding supports the notion that a fatty acid gradient from the vascular compartment to the skeletal muscle fibers might be one of the driving forces of net extraction of fatty acids by skeletal muscle.
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Superko, H. Robert, Scott M. Superko, Khurram Nasir, Arthur Agatston, and Brenda C. Garrett. "Omega-3 Fatty Acid Blood Levels." Circulation 128, no. 19 (November 5, 2013): 2154–61. http://dx.doi.org/10.1161/circulationaha.113.002731.

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Dhillon, Varinderpal S., Permal Deo, Ann Chua, Phil Thomas, and Michael Fenech. "Telomere Length in Healthy Adults Is Positively Associated With Polyunsaturated Fatty Acids, Including Arachidonic Acid, and Negatively With Saturated Fatty Acids." Journals of Gerontology: Series A 76, no. 1 (September 7, 2020): 3–6. http://dx.doi.org/10.1093/gerona/glaa213.

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Abstract Lymphocyte telomere length (LTL) is a biomarker of aging that may be modified by dietary factors including fat. Red blood cell fatty acid status is a well-validated indicator of long-term dietary intake of fat from various sources. Recent findings from epidemiological studies of LTL in relation to fatty acids in red blood cells are not conclusive. The present study was carried out to investigate if red blood cell fatty acid status in 174 healthy older South Australians is associated with LTL. Lymphocyte telomere length was measured by real-time qPCR and fatty acid content in red blood cells was measured by gas chromatography. Our results indicate that the majority of saturated fatty acids and monounsaturated fatty acids are negatively associated with LTL, whereas polyunsaturated fatty acids are positively associated with LTL. Multiple regression analysis revealed that arachidonic acid (C20:4n-6) is significantly, independently, positively correlated with LTL (β = 0.262; p = .000). The significant association of fatty acids, particularly C20:4n-6, with telomere length warrants further research.
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FARNWORTH, E. R., and J. K. G. KRAMER. "THE EFFECTS OF CHANGING SOW DIETARY FATTY ACIDS ON FETAL PLASMA FATTY ACID PATTERNS." Canadian Journal of Animal Science 69, no. 3 (September 1, 1989): 813–17. http://dx.doi.org/10.4141/cjas89-094.

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Sows were fed a control diet or one with added tallow or soybean oil during gestation. Sow and fetal blood plasma fatty acids were determined at 57, 85 and 110 d gestation. The sow plasma fatty acid pattern, particularly 18:2n-6, was influenced by diet, but showed little change during gestation. High levels of polyunsaturated fatty acids, especially 18:2n-6 and 20:4n-6, were found in sow plasma. Fetal blood fatty acids were not directly influenced by maternal diet, but showed changes as gestation progressed. In the fetal plasma, 20:4n-6 was the major long chain polyunsaturated fatty acid, but in addition, high levels of 22:6n-3 were also found. The percent n-6 fatty acids were in higher concentrations than the n-3 fatty acids in both maternal and fetal plasma. Key words: Fetus, blood, fatty acids, swine
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Panaroni, Cristina, Keertik Fulzele, Tomoaki Mori, Ka Tat Siu, Chukwuamaka Onyewadume, Allison Maebius, and Noopur Raje. "Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins." Blood 139, no. 6 (February 10, 2022): 876–88. http://dx.doi.org/10.1182/blood.2021013832.

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Abstract Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein multiple myeloma (MM) originates and resides. However, the nature of the interaction between MM cells and adipocytes remains unclear. Cancer-associated adipocytes support tumor cells through various mechanisms, including metabolic reprogramming of cancer cells. We hypothesized that metabolic interactions mediate the dependence of MM cells on BM adipocytes. Here we show that BM aspirates from precursor states of MM, including monoclonal gammopathy of undetermined significance and smoldering MM, exhibit significant upregulation of adipogenic commitment compared with healthy donors. In vitro coculture assays revealed an adipocyte-induced increase in MM cell proliferation in monoclonal gammopathy of undetermined significance/smoldering MM compared with newly diagnosed MM. Using murine MM cell/BM adipocyte coculture assays, we describe MM-induced lipolysis in adipocytes via activation of the lipolysis pathway. Upregulation of fatty acid transporters 1 and 4 on MM cells mediated the uptake of secreted free fatty acids (FFAs) by adjacent MM cells. The effect of FFAs on MM cells was dose dependent and revealed increased proliferation at lower concentrations vs induction of lipotoxicity at higher concentrations. Lipotoxicity occurred via the ferroptosis pathway. Exogenous treatment with arachidonic acid, a very-long-chain FFA, in a murine plasmacytoma model displayed a reduction in tumor burden. Taken together, our data reveal a novel pathway involving MM cell–induced lipolysis in BM adipocytes and suggest prevention of FFA uptake by MM cells as a potential target for myeloma therapeutics.
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Al, Monique D. M., Adriana C. Van Houwelingen, Arnold D. M. Kester, Tom H. M. Hasaart, AndrÉ E. P. De Jong, and Gerard Hornstra. "Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status." British Journal of Nutrition 74, no. 1 (July 1995): 55–68. http://dx.doi.org/10.1079/bjn19950106.

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Although essential fatty acids (EFA) and their longer chain, more unsaturated derivatives play a major role during pregnancy, hardly any information is available with respect to the course of the maternal EFA status during an uncomplicated pregnancy and its relationship to the neonatal EFA status. Therefore, a longitudinal study was started in which 110 pregnant women gave repeated blood samples from the 10th week of gestation until delivery. After birth a blood sample from the umbilical vein and a maternal venous blood sample were collected as well, and 6 months after delivery a final blood sample from the mother was taken. The absolute (mg/l) and relative (% total fatty acids) amounts of the fatty acids in plasma phospholipids were determined. The total amounts of fatty acids increased significantly during pregnancy. This pattern was similar for the individual fatty acids and fatty acid families. The relative amount of linoleic acid (18:2n−6) did not change during pregnancy, whereas the relative amount of arachidonic acid (20:4n−6) decreased. Despite maternal mobilization of docosahexaenoic acid (22:6n−3, DHA), suggested by a temporary increase in the DHA status until 18 weeks gestation, the DHA status steadily declined thereafter. This pattern was associated with a progressive increase in the DHA deficiency index in maternal blood throughout pregnancy and resulted in a sub-optimal neonatal DHA status. The overall maternal EFA status also declined steadily during pregnancy. Therefore, the question arises whether the mother, under the prevailing dietary conditions, is able to meet the high fetal requirement for EFA.
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Novitsky, V. V., R. S. Karpov, S. V. Klimenkov, A. B. Salmina, M. Yu Kotlovsky, S. V. Mashkovskaya, D. A. Kirichenko, et al. "Role of blood plasma fatty acids in pathogenesis of stable anginapectoris." Bulletin of Siberian Medicine 6, no. 4 (December 30, 2007): 41–45. http://dx.doi.org/10.20538/1682-0363-2007-4-41-45.

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In men and women suffering from stable angina pectoris of 1-2 functional classes and aged from 35 to 69 years old, decrease of C 23:0 and increase of C 18:1(11) fatty acids was observed regardless of sex, the content of the rest fatty acids changed depending on patients sex. Correlation was found that metabolism of fatty acids in this pathology group depends on patients sex: men in the control group showed decrease in the sum of omega-3 fatty acids as well as in the omega-3/omega-6 fatty acid ratio, while women showed decrease of omega-6 fatty acids at the constant sum of omega-3 fatty acids. Regardless of sex, the presence of this pathology is accompanied with decrease in correlations between fatty acids, as the number of correlations between saturated fatty acids increases and the number of correlations between not saturated and saturated fatty aсids decreases. Change in correlations between not saturated fatty acids depends on sex. In the number of patients having supernormal fatty acid contents, no pronounced differences were found between men and women.
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Dissertations / Theses on the topic "Blood fatty acid"

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Fox, Helen C. "Red blood cell membrane fatty acid in familial schizophrenia." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323135.

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Sibbons, Charlene. "Characterisation of polyunsaturated fatty acid synthesis in peripheral blood mononuclear cells." Thesis, University of Surrey, 2018. http://epubs.surrey.ac.uk/845807/.

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Conversion of the essential n-3 (18:3n-3) and n-6 (18:2n-6) fatty acids to longer chain polyunsaturated fatty acids (PUFA) involves sequential desaturation and elongation reactions. Previous studies have reported gender differences in n-3 PUFA synthesis, whereas the effect of age is less clear. n-3 PUFAs are reported to have important effects on immune cell function. A previous study reported long chain PUFA synthesis in mitogen stimulated but not quiescent peripheral blood mononuclear cells (PBMCs). However, the underlying mechanism is not known. PUFA synthesis was investigated in PBMCs incubated with [1-13C]18:3n-3 for 48 h. Activation with the T-lymphocyte mitogen concanavalin A (Con A) increased PUFA synthesis. 22:6n-3 synthesis was not detected. [1-13C] incorporation was greatest for 20:3n-3 suggesting initial chain elongation is an important fate for 18:3n-3. Con A increased expression of three key genes (FADS2, FADS1 and ELOVL5) involved in PUFA synthesis, suggesting upregulation of the pathway is controlled at the transcriptional level. ELOVL2 expression was negligible, possibly explaining the lack of 22:6n-3 synthesis. Con A increased methylation of 12 CpGs in the FADS2 promoter contradicting the general view that DNA methylation represses transcription. Subsequent 5’RACE analysis verified that activated PBMCs were not using an alternative promoter for FADS2 transcription. Contrary to expectation, 18:3n-3 conversion in activated PBMCs was not affected by gender or menopausal status and there was no clear age effect. PUFA synthesis was constitutive in the Jurkat T-lymphocyte leukaemic cell-line and was higher than in PBMCs. FADS2, FADS1 and ELOVL5 mRNA expression was also higher in Jurkat cells and was associated with 50% lower methylation of 17 CpGs in the FADS2 promoter, suggesting transcriptional dysregulation of PUFA synthesis in Jurkat cells involves altered DNA methylation. These findings have provided novel insights into the regulation of PUFA biosynthesis in PBMCs and upregulation of the pathway in activated PBMCs suggests that newly synthesised PUFAs may be important for cell function.
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Alabaster, Amy L. "Role of fatty acid sythase (FAS1) in blood-fed Aedes aegypti mosquitoes." Thesis, The University of Arizona, 2009. http://hdl.handle.net/10150/192277.

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Litwin, Nicole S. "Assessment of Red Blood Cell Membrane Fatty Acid Composition in Relation to Dietary Intake in Patients Undergoing Cardiac Catheterization." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2319.

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Red blood cells (RBC) have been shown to mediate plaque development seen in coronary artery disease (CAD). This study determined whether differences in RBC fatty acid (FA) composition were related to CAD risk. FAs were extracted from RBCs of 38 individuals who have undergone cardiac catheterization, 9 of whom had obstructive CAD, and analyzed via gas chromatography. Ferric reducing ability of plasma (FRAP) assay was used to determine oxidative stress. Food frequency questionnaires were used to correlate RBC omega-3 FA to daily intake of omega-3 FA. No correlation was found between RBC content and intake of omega-3 FA. FRAP values and RBC FA composition did not differ between the 2 groups with exception of the saturated FA, palmitic acid (p=0.018). These results suggest that RBC FA composition may differ between individuals with or at risk for CAD. Additional research is needed to validate this biomarker as a predictor of CAD.
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Litwin, Nicole S., W. Andrew Clark, Balraj Singh, and Kamesh Sivagnanam. "Assessment of Red Blood Cell Fatty Acid Profile in Relation to Dietary Intake in Patients Undergoing Cardiac Catheterization." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/2516.

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Careaga, de Houck Maria Monica. "Part 1. Metabolism of polyunsaturated fatty acid by human platelets ; Part 2. Phospholipid composition of rat blood cells after feeding diets containing corn oil or corn/fish oil /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487584612162702.

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Litwin, Nicole S., Norman A. Assad, W. Andrew Clark, Tasha Ferrell, Ray M. Mohseni, and Shimin Zheng. "Oxidative Stress, Dietary Fat Intake and Red Blood Cell Membrane Fatty Acid Composition in Women with and without Fertility Problems." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/92.

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Chan, Yen-Ming 1980. "The effect of fatty acid composition of plant sterol esters on blood lipid profiles and plasma plant sterol levels in hypercholesterolemic subjects /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97923.

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To evaluate the relative efficacy of plant sterols (PS) esterified with the fatty acids from fish oil (PS-FO), olive oil (PS-OO) and sunflower oil (PS-SO) on blood lipid and PS concentrations, 21 hyperlipidemic subjects were randomly assigned to each of five treatments for 28 days using a cross-over design. The results showed that: (1) in a comparison of olive oil (OO), fish oil (FO), PS-FO and PS-SO subgroup, PS-FO reduced triacylglycerols (TG) relative to PS-SO. Total cholesterol (T-C)/high-density lipoprotein cholesterol (HDL-C) ratio was reduced with PS-FO compared with FO. Plasma PS levels were increased with PS-SO and PS-FO. (2) in a comparison of OO, PS-SO and PS-OO subgroup, PS-OO had a larger decrease in T-C than OO, while PS-SO and OO reduced T-C equally. Both PS-SO and PS-OO elevated plasma PS levels. Overall, PS-FO and PS-OO have a higher potential for decreasing the risk of cardiovascular disease in hyperlipidemic subjects than PS-SO and OO supplementations.
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Al, Ghannami Samia. "Nutritional intake, body composition, plasma lipids and fat-soluble vitamins, red blood cell fatty acid profile and behaviour of Omani school children." Thesis, London Metropolitan University, 2016. http://repository.londonmet.ac.uk/1223/.

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Background: The traditional Omani diet of dates, milk, rice, brown bread, fish and vegetables has undergone considerable change, now resembling a Western diet that is high in calories, high glycaemic index carbohydrates, total fat and saturated, trans and omega 6 fatty acids, and low in omega-3 fatty acids and essential micronutrients. The available data on daily food intake and its impact on micro- and macro-nutrients are scanty in the Arab world. Obtaining these data is especially important in light of the growing prevalence of non-communicable diseases (NCDs) - cardiovascular diseases, diabetes, cancer and respiratory diseases - which now account for more than 60% of the global disease burden and mortality, and contribute to more than 50% of annual deaths in Arabian countries, including Oman. Moreover, obesity, an antecedent of NCDs, has reached epidemic proportions in the region. Since NCDs develop gradually during the course of the lifespan, various national and international committees on NCDs have recommended that children and young adults be the primary focus of any action plan that aims to prevent and control non-communicable diseases. Specific aims: The aims of the study are: a) To assess the nutrient intake, body composition, blood lipids, blood pressure, blood glucose and cognitive behaviour of Omani school children; b) To assess the level of Vitamin A, D, E, and Beta Carotene among the Omani school children c) To assess the level of red blood cell fatty acids of Omani school children d) To investigate the effect of fish consumption on red blood cell omega-3 fatty acids and plasma fat-soluble vitamins; e) To investigate the impact of omega-3 fatty acids obtained from fish oil capsule on the red blood cell omega-3 fatty acids and plasma fat-soluble vitamins. Methods: Children ages 9 and 10 years (n = 314) were recruited from three randomly selected schools in the Muscat Governorate. The schools were assigned to a fish, fish oil, or control group and the children were accordingly provided a lightly grilled oily fish, a re-esterified triacylglycerol fish oil capsule, or no fish for 12 weeks. Baseline body weight, height and body mass index were assessed and a non-fasting blood sample collected at baseline and after 12 weeks of intervention. Data on food intake were gathered using a 24-hour recall questionnaire; also collected were data on weight, height, blood pressure, triglycerides and fasting glucose. In addition, teachers completed the National Initiative for Children’s Health Quality Vanderbilt Assessment Scales-Teacher Assessment Scale to assess the prevalence and sub-types of ADHD. Results: At baseline, a significant number of the children had low levels of vitamin D, and omega-3 fatty acids. The low levels of vitamin D and omega-3 fatty acids were ameliorated significantly by fish consumption and fish oil supplementation. In terms of weight, the prevalence of overweight or obesity for the total sample was 28.2% (10%, 46%) and 22.6% (8%, 38%). That is, about one fourth of the study subjects were overweight or obese. With regards to ADHD, the prevalence rate of PIS, PHIS and ADHDCIH among Omani school children was 7.3%, 3% and 8.8%, respectively. After 12 weeks intervention, the children who received fish oil (54.1±17.5 nmol/L; p < 0.001) and fish (49.2±17.4 nmol/L; p < 0.05) had elevated levels of vitamin D than those who did not (42.3±17.5 nmol/L). The fish oil (1.2±0.70 μmol/L) and fish (1.20±0.7 μmol/L) groups also had higher concentrations of beta carotene than the placebo group (0.85±0.43 μmol/L; p < 0.0001). Systolic and diastolic blood pressure (p=0.0001) and plasma triglycerides (p < 0.05) but not HDL, LDL and total cholesterol (p > 0.05) were lower in the fish oil group compared with those who were fed oily fish. Conclusions: This study provides important and underreported data on nutrient intake levels by school children in Arab world. For the first time, these data will be available as a benchmark for future research and health programs in the region. A large number of boys and girls had diets that failed to provide the recommended levels of daily nutrients. This study also indicates that ADHD is relatively common among Omani school children; additional studies are needed to assess the generalisability of these findings. Vitamin D deficiency is prevalent in Omani school children, but can be mitigated with omega-3 fatty acid supplementation. This study also provides evidence that Omani pre-adolescents have a low level n-3 fatty acid index that can be ameliorated by fish oil supplementation or consumption of oily fish. Hence, there is a need for a child-focused program of food fortification, school feeding programmes, targeted intervention with n-3 fatty acid enriched food products, family nutrition education and outdoor activities to alleviate the problem.
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Stelzleni, Elizabeth Lindsay. "Effect of dietary n-3 fatty acid source on plasma, red blood cell and milk composition and immune status of mares and foals." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0014621.

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Books on the topic "Blood fatty acid"

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Salo, Pia. Fatty acid composition of serum lipid fractions in young children in a prospective randomised trial of low-saturated fat, low-cholesterol diet. Turku, Finland: University of Turku, 1999., 1999.

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1955-, Kristensen S. D., ed. n-3 Fatty acids: Prevention and treatment in vascular disease. London: Springer-Verlag, 1996.

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Moilanen, Teemu. Serum fatty acids in Finnish children and adolescents: With special reference to relationships with other coronary heart disease risk factors. Tampere: University of Tampere, 1987.

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Ėndakova, Ė. A. Modifika︠t︡si︠i︡a sostava zhirnykh kislot krovi pri serdechno-sosudistykh zabolevani︠i︡akh. Vladivostok: Dalʹnauka, 2002.

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1954-, De Caterina R., European Society for Clinical Investigation., and Workshop on Fish Oil and Vascular Disease (2nd : 1993 : Heidelberg, Germany), eds. n-3 Fatty acids and vascular disease: Background and pathophysiology, hyperlipidaemia, renal diseases, ischaemic heart disease. London: Springer-Verlag, 1993.

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translator, Xie Chenghan, ed. Jing ren no xue guan ni ling jian kang fa: Riben ming yi qin zheng nian qing 15 sui. Xinbei Shi: Hui hong qi ye gu fen you xian gong si, 2016.

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C, Somogyi J., Renaud Serge, and Astier-Dumas M, eds. Emerging problems in human nutrition. Basel: Karger, 1987.

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1939-, Frölich J. C., and Schacky C. von, eds. Fish, fish oil, and human health. München: W. Zuckschwerdt Verlag, 1992.

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Ph, Douste-Blazy, and Vanhoutte Paul M, eds. Fish oil and blood-vessel wall interactions: Proceedings of the International Symposium held in Granada (Spain) February 23-25, 1990. Paris: John Libbey Eurotext, 1991.

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M, Vanhoutte Paul, and Douste-Blazy Ph, eds. Fish oil and blood-vessel wall interactions: Proceedings of the international symposium held in Granada (Spain) February 23-25, 1990. Paris: J. Libbey Eurotext, 1991.

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Book chapters on the topic "Blood fatty acid"

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Banks, William A., Abba J. Kastin, and Stanley I. Rapoport. "Permeability of the Blood-Brain Barrier to Circulating Free Fatty Acids." In Handbook of Essential Fatty Acid Biology, 3–14. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-4757-2582-7_1.

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Ferreri, Carla, Anna Sansone, Alessandra Ferocino, Itziar Tueros, and Sara Arranz Martinez. "Fatty Acid Profile of Red Blood Cells as Markers in Dietary Regimes and Beyond." In Biomarkers in Disease: Methods, Discoveries and Applications, 403–27. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-07389-2_26.

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Ferreri, Carla, Anna Sansone, Alessandra Ferocino, Itziar Tueros, and Sara Arranz Martinez. "Fatty Acid Profile of Red Blood Cells as Markers in Dietary Regimes and beyond." In Biomarkers in Disease: Methods, Discoveries and Applications, 1–25. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-81304-8_26-1.

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Galli, Claudio, Patrizia Risé, Silvia Ghezzi, and Franca Marangoni. "Fast Determination of Fatty Acids in Whole Blood Collected from Fingertips: Application to the Assessment of Fatty Acid Patterns (and Various Indexes) in Population Studies." In World Review of Nutrition and Dietetics, 35–45. Basel: KARGER, 2009. http://dx.doi.org/10.1159/000235709.

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Saynor, R., T. Gillott, and T. Doyle. "Changes in Postprandial Serum Lipids and Blood Viscosity before and after n-3 Fatty Acid Consumption." In Cardiovascular Disease, 455–61. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5296-9_50.

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Ernst, E., and A. Matrai. "Effects of n-3 Fatty Acid Supplementation on the Rheological Behavior of Human Blood Measured Ex Vivo." In Biofluid Mechanics, 351–55. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-52338-0_44.

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Rapoport, S. I., and P. J. Robinson. "Long-Chain Fatty Acid Transport at the Blood-Brain Barrier and Incorporation into Brain Phospholipids: A New In Vivo Method for Examining Neuroplasticity, and Brain Second Messenger Systems Involving Phospholipase A2 Activation." In New Concepts of a Blood—Brain Barrier, 119–40. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1054-7_13.

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Marangoni, Franca, Claudio Colombo, and Claudio Galli. "A Method for the Direct Evaluation of the Fatty Acid Status in a Drop of Blood from a Fingertip in Humans." In World Review of Nutrition and Dietetics, 139–43. Basel: KARGER, 2005. http://dx.doi.org/10.1159/000088227.

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Hornstra, G. "The Effect of n-3 Fatty Acids on Blood Coagulation." In Fish Oil and Vascular Disease, 65–72. London: Springer London, 1992. http://dx.doi.org/10.1007/978-1-4471-3890-7_10.

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Dissanayake, Hasthi U. W., Melinda Phang, and Michael R. Skilton. "Maternal n-3 Fatty Acids and Blood Pressure in Children." In Diet, Nutrition, and Fetal Programming, 279–92. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60289-9_21.

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Conference papers on the topic "Blood fatty acid"

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Pasiyeshvili, Lyudmila, and Tamara Pasiieshvili. "Fatty acid blood spectrum in patients with asthma." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa3371.

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Chavarro, Jorge E., Meir J. Stampfer, Hannia Campos, Howard D. Sesso, and Jing Ma. "Abstract 896: Pre-diagnostic blood fatty acid levels and prostate cancer mortality." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-896.

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Chamulitrat, W., J. Seeßle, B. Javaheri-Haghighi, S. Döring, X. Zhu, S. Tuma-Kellner, H. Gan-Schreier, et al. "Intestinal deletion of fatty acid transport protein 4 in mice increases blood chylomicrons." In 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402169.

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Sivarajah, Maheshwaran, SuhYueh Lim, Galina Chipitsyna, Qiaoke Gong, Tamer Aziz, Agnes Witkiewicz, Charles J. Yeo, and Hwyda A. Arafat. "Abstract 51: Blood pressure lowering medications disrupt fatty acid metabolism in pancreatic cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-51.

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Simonsen, T., Å. Vårtun, V. Lyngmo, G. Hornstra, and A. Nordøy. "SERUM PREPARED AFTER DAILY INTAKE OF FISH INHIBITS PGI-2 PRODUCTION BUT NOT PLATELET INHIBITORY ACTIVITY OF ENDOTHELIAL CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643401.

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Healthy males were given dietary supplement of 100 g mackerelpasta for six weeks. Controlls were given meatpasta. Blood were collected before and at the end of the dietary intervention. Fatty acid composition of total phospholipids in serum and free fatty acids were measured by GLCHuman endothelium cells were grown in medium supplemented with 10% serum prepared from blood of the mackerel and controll groups. The medium was then examined for PGI-2 by RIA of 6-Keto-PGFIα , and for platelet aggregation inhibitory activity (PAIA) measured as inhibition of collagen induced platelet aggregation in platelet rich plasma.Fatty acids of total phospholipids and FFA of serum showed a significant decrease in the ratio of Arachidonic acid (20:4 n-6) to Eicosapentaenoic acid (20:5 n-3) in the mackerel group.The 6-Keto-PGFlα was significantly lower in the medium added serum from the mackerel group at the end of the period than at start. PAIA was not reduced by serum collected after fish consumption.We conclude that dietary fish contribute to factors in serum, inhibiting PGI-2 production in endothelial cells in vitro. However, the ability of endothelial cells to inhibit platelet aggregation was not affected
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Ward, M., T. Pavlina, R. Butchin, R. Johnson, and R. Cotter. "RAPID ONSET INHIBITION OF AFRICAN GREEN MONKEY PLATELETS AFTER INTRAVENOUS ADMINISTRATION OF A MARINE OIL LIPID EMULSION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643386.

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To evaluate how rapidly and to what extent a lipid emulsion rich in n-3 fatty acids could alter platelet function, six male juvenile African Green Monkeys (4-6 kg) were given a 6-hour IV continuous infusion of a 10% marine oil (MO) lipid emulsion (5 ml /kg/hr). Following a 21-day washout period, the same monkeys were given a similar infusion of a 10% soybean oil (SO) lipid emulsion (TRAVAMULSION®, Travenol Labs). Blood samples were collected pre-infusion, and at 6, 12, and 24 hours following initiation of infusion, upon which the following were measured: whole blood platelet aggregation and thromboxane B2 release following collagen activation, platelet count, and platelet total fatty acid composition (pre-infusion and 24 hrs only). Lipid Emulsion Fatty Acid Composition: mg/ml(% total F.A.) Both emulsions elicited comparable reductions in both platelet aggregation and thromboxane B2 release immediately following infusion (6 hr). Platelet aggregation response after MO was significantly less than that after SO at both 12 (pc.001) and 24 hrs (p<.001), and thromboxane B2 release was significantly less after MO vs SO at 24 hrs (p<.03). Platelet counts remained unchanged after both treatments. Platelet total fatty acid analyses revealed significant increases in % total F.A. for C20:5 [1.87(pre) vs 4.79(24hr); p<.005] and for C22:6 [1.09(pre) vs 3.15(24hr); p<.001] and significant decreases in % total F.A. for C18:2 [8.94(pre) vs 7.77(24hr); p<.05] and C20:4 [22.6(pre) vs 19.6(24hr) p<.05], following infusion of M0. Following infusion of SO, the % total F.A. change in C22:6 was the only one of significance [0.85(pre) vs 1.25(24hr); p<.05]. This was attributed to the C18:3 in the SO lipid emulsion. Whereas the IV infusion of an n-6 rich lipid emulsion has little effect upon platelet fatty acid composition and function, similar administration of an n-3 rich lipid emulsion markedly reduces platelet function and effects a significant increase in the n-3/n-6 fatty acid ratio of the platelets.
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Hornstra, E. G., A. H. Hennissen, R. Kalafusz, and D. T. S. Tan. "THE ANTITHROMBOTIC EFFECT OF PALM OIL IS CORRELATED WITH ITS CONTENTS OF VITAMIN E." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643804.

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Dietary saturated fatty acids are known to increase platelet aggregation and arterial thrombogenesis.We recently demonstrated, however, that palm oil, rich in saturated palmitic acid, has a distinct antithrombotic affect, which is associated with a decrease of the thromboxane-prostacyclin ratio in activated whole blood. To identify the antithrombotic component(s) of palm oil, seven palm oil fractions were prepared with comparable fatty acid compositions of the triglycerides but containing Various amounts of non-triglyceride material with different compositions.These fractions were fed to rats in amounts of 50 energy% for a period of 8 weeks, after which arterial thrombosis tendency was measured upon insertion of an aortic prosthesis, the aorta-loop. During loop insertion, 1 ml blood was collected in citrate for measuring platelet aggregation and ATP release in response to collagen, using the Chronolog whole blood lumi-aggregometer. Arterial thrombosis tendency was found to be negatively related to the total amount of non-triglyceride material in the various fractions (r = 0.78; p <0.05).No significant relationship was observed between arterial thrombus formation and the various sterols present in the non-triglyceride material.A significant negative correlation was found, however, with a-tocopherol (r = 0.86; p <.02). Collagen-induced platelet aggregation and ATP release in whole blood were not correlated to total amounts or α-tocopherol content of the non-triglyceride material.However, significant positive relationships were found between these platelet functions and the amountsof the various sterols (Campesterol: r = 0.70; P < 0.10 β-sitostero1 : r = 0.69; P <0.10. Cholesterol : r = 0.81; P < 0.05).These findings demonstrate that effects of edible oils on platelet function and arterial thrombogenesisare not only mediated by the fatty acid compostion of the triglycerides, but can also be determined by 'minor components', present in the non-triglyceride part of the oils.
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Park, Mi Soon, Yu Jin Lee, and In-Hwan Kim. "Synthesis of Pinolenic Acid Enriched Triacylglycerol from Pine Nut Oil via a Two-step Consecutive Enzyme Reaction." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/jlcw3538.

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Pinolenic acid (PLA), Δ‐5,9,12‐octadecatrienoic acid-C18:3, is a plant origin polyunsaturated fatty acid and is contained abundantly in pine nut oil. PLA has several health benefits, such as the reduction of atherosclerosis, inflammation, and blood pressure. In addition, PLA may work as an appetite suppressant by increasing the effect of satiety hormones, such as cholecystokinin and glucagon-like peptide-1. The aim of this study was to synthesize PLA-enriched TAG from pine nut oil via a two-step lipase-catalyzed reaction, which is ethanolysis and esterification. In the first step, PLA was enriched up to ca. 42% as ethyl ester form, from 14% in pine nut oil by Lipozyme 435-catalyzed ethanolysis with an excess amount of ethanol. In the second step, PLA-enriched TAG was synthesized with glycerol and two different acyl donors, PLA-enriched fatty acid and PLA-enriched ethyl ester via Lipozyme 435-catalyzed esterification under vacuum condition. The TAG conversion and reaction rate with fatty acid form were significantly higher than those with ethyl ester form. Thus, the effect of temperature and vacuum on the synthesis of PLA-enriched TAG were investigated with fatty acid form as an acyl donor. The optimum temperature and vacuum were 60 oC and 5 torr, respectively. The TAG conversion of approximately 95% was achieved after 12 h under the optimum conditions. In addition, fatty acid compositions of TAG synthesized at different reaction times were also explored.
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Von Gerichten, Johanna, Annette Holland, Barbara Fielding, Elizabeth Miles, and Graham Burdge. "α-Linolenic acid metabolism in human CD3+ T cells favours oxylipin production over polyunsaturated fatty acid synthesis." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/asgv6871.

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The essential dietary fatty acid α-linolenic acid (ALA) can be converted into anti-inflammatory 18 carbon oxylipins or into longer chain n€‘3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The partitioning of ALA between these alternative metabolic fates is not understood. To address this, peripheral blood CD3+ T cells from healthy volunteers (18-30 years; n=10) were cultured for 48h, with or without concanavalin A (10µg/ml) in 10% (v/v) pooled donor plasma with low ALA (20 µM) or high ALA (40 µM) concentrations (1:10 [13C]€‘labelled/unlabelled). [13C]ALA metabolites were detected either by GC-isotope ratio mass spectrometry for intracellular PUFA or by LC-MS/MS for oxylipins in cell culture supernatant. The ratio of the labelled metabolites hydroxyoctatrienoic acid ([13C]HOTrE) and dihydroxyoctadecaenoic acid ([13C]DiHODE) to [13C]ALA were 1.8±0.2 / 7.2±1.1 and 0.9±0.2 / 4.3±0.6 for low / high ALA, respectively, compared to the eicosatrienoic acid ([13C]20:3n€‘3) to [13C]ALA ratio of 0.002±0.0001 / 0.02±0.003 in stimulated T cells. Results from unstimulated cells were similar. Furthermore, oxylipins from all PUFA precursors were analysed in the culture supernatant of the T cells. The ratio of oxylipin concentrations in high compared to low ALA cultures was 1.4±0.1 for EPA-derived dihydroxyeicosatetraenoic acid (DiHETE), 5.6±0.9 for DHA-derived dihydroxydocosapentaenoic acid (DiHDPE), 7.9±2.7 for resolvin RvE1 and 2.0±0.3 for resolvin RvD1. The total oxylipin profile was not altered significantly by mitogen stimulation. These findings show that ALA is used primarily by T cells for constitutive production of anti-inflammatory lipid mediators rather than synthesis of longer chain PUFA. Further, ALA addition changes the secreted oxylipins towards a less-inflammatory profile. This has implications for understanding the effects of dietary PUFA on immune function.
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Osteurd, B., J. O. Olsen, and L. Wilsgard. "MONOCYTE STIMULATION IN BLOOD EXPRESSED BY INDUCED THROMBOPLASTIN SYNTHESIS IS CONTROLLED BY THE RELEASE OF ARACHIDONIC ACID AND THE FUNCTION OF PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643289.

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Inhibitors of phoapholipaae A2, block the release of arachidonic acid (20:4) in the cell membrane. Adding such an inhibitor, dibromoacetophenone (20µM) to hepar-inized blood incubated with LPS for 2 hours, blocked totally the induction of thromboplastin synthesis. Liposomes prepared from soyalecithin, containing 60* linoleic acid (18:2) had no stimulatory effect by themselves, but enhanced the stimulating effect of LPS up to 10 fold. When the liposomes were added to the blood samples 0,15,30,60 and 90 min after the LPS had been added, a time dependent response of the liposomes was seen. Blood samples incubated with LPS for 2 hours but only exposed to liposomes for 30 min had monocytes with a thromboplastin activity of 30x10/10-3cells as compared to an activity of 152x10 /10-3 cells in the monocytes of blood incubated with LPS and liposomes for 2 hours. Although the linoleic acid (18:2) is metabolized to arachidonic acid (20:4), it may be more likely that the effect of liposomes is exerted by a mechanism whereby the fatty acid 18:2 is preventing arachidonic acid from being reacylated. This will cause more 20:4 to be free and metabolized to give products required for monocyte activation.A tremendous difference in response to monocyte stimulation between different individuals has been observed. Recently we found that this phenomenon could partially be explained by very active platelets in those with high cell stimuli response. Thus, when platelet rich plasma (PRP) from a high responder was incubated with white cells from a low responder followed by incubation with LPS, there was a drastic increase in monocyte response as compared to the samples where PRP from the low responder was incubated with white cells of its own plus LPS. PRP from a low responder combined with white cells of a high responder resulted in a low response of the monocytes to LPS stimuli.It is concluded that fatty acids and the activity function of platelets may play a central role in monocyte function.
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Reports on the topic "Blood fatty acid"

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Glazer, Itamar, Alice Churchill, Galina Gindin, and Michael Samish. Genomic and Organismal Studies to Elucidate the Mechanisms of Infectivity of Entomopathogenic Fungi to Ticks. United States Department of Agriculture, January 2013. http://dx.doi.org/10.32747/2013.7593382.bard.

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The overall goal of this research was to elucidate the factors affecting early development of Metarhizium spp. (previously named M. anisopliae) on ticks or tick cuticle extracts and the molecular basis of these early infection processes. The original objectives were: 1. Characterize the pre-penetration events (adhesion, germination and appressorium formation) of spores of M. anisopliae strains with high or low virulence during tick infection. 2. Create GFP-expressing strains of M. anisopliae tick pathogens having high and low virulence to compare their progress of infection by microscopy. 3. Use microarray analyses, primarily with existing M. anisopliae EST sequences in GenBank, to identify and characterize fungal genes whose expression is regulated in response to host cuticle extracts. Objective 3 was later modified (as approved by BARD) to use RNAseq to characterize the early stages of fungal gene expression during infection of intact host cuticles. This new method provides a massively larger and more informative dataset and allows us to take advantage of a) recently published genomes of Metarhizium robertsii and M. acridum for RNAseq data analysis, and b) newly developed and highly efficient cDNA sequencing technologies that are relatively low cost and, therefore, allow deep sequencing of multiple transcriptome samples. We examined pre-penetration and penetration events that differentiate high and low virulence strains of Metarhizium spp., focusing on spore adhesion, germination, appressorium formation, and penetration of tick integuments. Initiation of fungal infection was compared on susceptible and resistant tick species at different tick developmental stages. In vitro studies comparing the effects of protein and fatty acid profiles from tick cuticle extracts demonstrated that resistant tick cuticles contain higher concentrations of specific lipids that inhibit fungal development than do susceptible tick cuticles, suggesting one mechanism of Ixodidae resistance to fungal entomopathogens (Objective 1). We used molecular markers to determine that the three M. anisopliae strains from Israel that we studied actually were three distinct species. M. brunneum is highly virulent against the tick Rhipicephalus annulatus, M. pingshaense and M. robertsii are intermediate in virulence, and M. majus is of low virulence. We transformed all four Metarhizium species to express GFP and used them in pathogenicity assays against diverse tick species. Key findings were that a) resistant ticks inhibit Metarhizium infection prior to hemocoel invasion by reducing fungal viability on the cuticle surface (Objective 2), as was supported by the in vitro studies of Objective 1, and b) Metarhizium kills susceptible ticks after cuticle penetration but prior to hemocoel colonization. Transcriptome studies of the most virulent species, M. brunneum, are in progress and include analyses of ungerminated conidia and conidia germination and development on a low nutrient medium or on susceptible R. annulatus exoskeleton (Objective 3). We anticipate these studies will contribute to identifying fungal genetic factors that increase virulence and speed of kill and may help reveal tick chemistries that could be included in biocontrol formulations to increase efficacy. Methodologies developed to screen tick cuticle extracts for ability to support conidia germination and development may help in the selection of wild fungi with increased virulence against resistant ticks. The overall knowledge gained should contribute not only to the improvement of tick control but also to the control of other blood-sucking arthropods and related plant pests. Use of bio-based agents for controlling arthropods will contribute to a healthier, more sustainable environment and serve a growing number of organic food farmers.
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