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Journal articles on the topic 'Blood donors China Tibet'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Zheng, Xiaofan, Wei Ding, Xia Ling, Jie Shi, Jie Dong, Guangshu Yu, Yan Chen, et al. "Prevalence of Treponema Pallidum Antibody among Volunteer Blood Donors in China." Canadian Journal of Infectious Diseases and Medical Microbiology 2022 (August 8, 2022): 1–6. http://dx.doi.org/10.1155/2022/1668703.

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Background. Infection with syphilis is still a major public health problem. The precise data for syphilis seroprevalence in the populations will help to develop a strategy for prevention and treatment of it. However, the data for syphilis prevalence in continuous years among volunteer blood donors in China is rare. Methods. A retrospective study for Treponema pallidum (TP) antibody in blood donors was conducted from January 2010 to December 2019 at the Blood Center of Zhejiang Province, China. TP antibody was detected with two different reagents using enzyme-linked immunosorbent assay and the only sample which was reactive in the two reagents was defined as seropositive. Results. A total of 992,646 volunteer blood donors were analyzed and the positive rate of TP antibody in the blood donors was 0.43%. From 2010 to 2019, the positive rates of TP antibody were 0.53%, 0.51%, 0.51%, 0.43%, 0.36%, 0.18%, 0.11%, 0.12%, 0.11%, and 0.10%, respectively. The positive rates of TP antibody were significantly different among blood donor age group ( p < 0.001 ), with the highest positive rate in 45–54-years-old group (0.93%). The positive rates of TP antibody in male and female blood donors were 0.44% and 0.41%, respectively. The positive rate was 0.57% among the first-time blood donors, which was significantly higher than that of the repeat blood donors (0.17%). The positive rate of TP antibody in blood donors decreased gradually with the increase of educational level. Conclusion. The syphilis seroprevalence is low in the blood donors of the Hangzhou area, and the positive rate of blood donors is associated with age, educational level, and times of blood donation. Increasing the number of repeat blood donations is helpful to improve blood safety.

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2

Wang, Taiwu, Yifang Han, Zuanqin Pan, Hengzhong Wang, Meng Yuan, and Hong Lin. "Seroprevalence of Toxoplasma gondii infection in blood donors in mainland China: a systematic review and meta-analysis." Parasite 25 (2018): 36. http://dx.doi.org/10.1051/parasite/2018037.

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Toxoplasma gondii transmitted from blood donors to receiving patients has become a concern as numerous articles about the epidemiology of T. gondii infection in blood donors from different provinces have been published in China. This study aimed to evaluate the seroprevalence of T. gondii infection in Chinese blood donors using a meta-analysis. A total of 40 eligible studies, published from 1986 to 2017 and covering 18 provinces and municipalities were included. Among a total of 49,784 Chinese blood donors, the overall IgG seroprevalence of T. gondii infection was 6.26% (95% CI: 4.62%–8.13%). The highest prevalence was in the Northeast of China and the lowest in Central China. The infection rate increased slowly over the years, but not significantly. A statistically significant correlation was found between the seroprevalence of T. gondii infection and the detection method and educational level (p < 0.01). There was no relationship between age, gender, occupation and blood type and seroprevalence of T. gondii (p > 0.05). The prevalence of antibodies to T. gondii in Chinese blood donors was lower than in other countries, but the risk of transfusion-transmitted toxoplasmosis still exits. More concise methods are still needed to evaluate the possibility of transfusion-transmitted toxoplasmosis from blood donors.

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3

Yang, Zhen, Yan-Xing Han, Jian-Dong Jiang, Zhen Yang, Yong-Xin Yu, and Yan Qiu. "HCV positivity rate in the seronegative blood donors in China." Biomedicine & Pharmacotherapy 63, no. 4 (May 2009): 319–20. http://dx.doi.org/10.1016/j.biopha.2009.01.004.

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4

Zhang, Lifan, Meilin Yao, Hongrui Liu, and Shuang Zheng. "The Effect of Functional Motivation on Future Intention to Donate Blood: Moderating Role of the Blood Donor’s Stage." International Journal of Environmental Research and Public Health 18, no. 17 (August 29, 2021): 9115. http://dx.doi.org/10.3390/ijerph18179115.

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The low retention rate and lack of long-term blood donors are still worldwide problems, and the fostering and retaining of more blood donors has posed an urgent problem that requires a solution. The purpose of this study was to explore the role of functional motivation and blood donor stage in the future intention to donate blood. Three sites in China provided 252 blood donors who filled out a questionnaire including the volunteer function inventory, their future intention to donate blood, number of blood donations and demographic information. Based on a functional motivation approach, we investigated the motivations that influence unpaid blood donors’ future intention through qualitative interview methods. The results showed that blood donor stage moderated the relationship between values motivation and future intention to donate blood. More specifically, the predictive effect of values motivation on future intention decreased gradually from new donors to regular donors. Our study found that the effect of various motivations on blood donors’ intention was conditional; this effect changed with the development of blood donor behavioral stages. The results are significant in practice for establishing effective intervene strategies in maintaining blood donors.

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5

Hu, Wei, Hongdao Meng, Qiuyue Hu, Lijuan Feng, and Xianguo Qu. "Blood donation from 2006 to 2015 in Zhejiang Province, China: annual consecutive cross-sectional studies." BMJ Open 9, no. 5 (May 2019): e023514. http://dx.doi.org/10.1136/bmjopen-2018-023514.

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ObjectivesTo describe the basic demographical characteristics of whole blood donors in Zhejiang Province, China, from 2006 to 2015 and to examine the trends in individual characteristics associated with blood donation and the relationship between weight and donation.DesignCross-sectional study comparing characteristics of blood donors and annual donations for the period 2006 to 2015.SettingUrban and rural communities in Zhejiang, China(11 cities, 89 districts or counties and 1379 townships).Participants3 226 571 volunteer blood donors.Outcome measuresVolume of each whole blood donation and donation frequency. All data were collected by trained staff and entered into a standardised electronic information system.ResultsThe number of blood donations generally trended up in Zhejiang Province from 2006 to 2015. Donors were predominately males aged 18 to 25 years, but this major donor age group shifted to the 26 to 45 year range by 2015. The rate of repeated blood donation was 30.8 per cent. The blood volume per donation concentrated in 200 mL and 400 mL categories has been gradually shifted to 300 mL and 400 mL. Approximately one-third of donors had a college education. The average weight of donors increased over time for both men and women. Both the blood volume of each donation and donation frequency were proportional to weight.ConclusionsThe trend of voluntary non-remunerated blood donation in Zhejiang province is positive. However, given the expected growth in demand for whole blood, more research is needed to increase both the donor pool and the rate of repeated donation. The relationship between body weight and blood donation warrants further study because while improving nutritional status is associated with higher average donation volume and more frequent donations, overnutrition may lead to poorer quality of donated blood. Blood donation may present a unique opportunity for health education and body weight management to monitor and improve population health.

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6

Su, Shu, Ting Ma, Yang Sun, Lingxia Guo, Xiaodong Su, Wenhua Wang, Xinxin Xie, et al. "Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China." Journal of Oncology 2022 (July 8, 2022): 1–9. http://dx.doi.org/10.1155/2022/7647431.

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This study aims to identify the relationship between blood donation and malignant and benign tumour hospitalization risk. The cohort study was constructed in Shaanxi, China, to include blood donors and match nonblood donors one-to-one by gender, age, and county of residence. The study compared the hospitalization records of two groups from 2012 to 2018. A log-binomial regression model was used to estimate the relative risk (RR) of tumour risk between donors and nonblood donors among different age groups. A total of 1,625,599 donors were recruited (including 968,823 males) and compared with the matched nonblood donor group. Significantly lower risk of malignancy in males was found among donors (adjusted RR: 0.82, 95% CI: 0.75–0.92). Lower risks for specific types of tumours among donors were observed, including liver (0.42, [0.28–0.67]), lung (0.74, [0.59–0.87]), lymphoma (0.75, [0.62–0.85]), and oesophagus (0.55, [0.41–0.72]). However, the risk of brain cancer was higher among male donors (RR 1.19 [1.06–1.29]). Among female donors, lower risk of liver (0.57, [0.42–0.79]) and oesophagus malignancy (0.73, [0.62–0.88]) was observed. For benign tumours, male donors have a lower risk of benign skin tumour (0.79, [0.62–0.94]) and hemangioma and lymphangioma (0.75, [0.51–0.89]), while female donors have a lower risk in hemangioma and lymphangioma (0.65, [0.44–0.83]). We also found that the risk decreased with age among donors in the prevalence of tumours compared to that in nonblood donors ( p < 0.05 ). Blood donation appears to be significantly associated with various tumour risks among both males and females. Overall, the risk of tumours decreased more substantially with age in blood donors compared with nonblood donors. Further research is warranted to investigate the impact of ‘health donor effects’ on these findings.

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7

Xia, W., X. Ye, X. Xu, D. Chen, J. Deng, Y. Chen, H. Ding, et al. "The prevalence of leucocyte alloantibodies in blood donors from South China." Transfusion Medicine 25, no. 6 (December 2015): 385–92. http://dx.doi.org/10.1111/tme.12276.

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8

Gao, Lei, Xia Rong, Miao He, Ling Zhang, Tingting Li, Wenjing Wang, Daniel Candotti, Jean‐Pierre Allain, Yongshui Fu, and Chengyao Li. "Metagenomic analysis of potential pathogens from blood donors in Guangzhou, China." Transfusion Medicine 30, no. 1 (February 2020): 61–69. http://dx.doi.org/10.1111/tme.12657.

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9

Guo, Nan, Jingxing Wang, Paul Ness, Fuzhu Yao, Xiangdong Dong, Xinhong Bi, Heili Mei, et al. "Demographics of apheresis platelet donors in five blood centers in China." Transfusion 52, no. 3 (September 2, 2011): 560–66. http://dx.doi.org/10.1111/j.1537-2995.2011.03328.x.

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10

Guan, Yue. "When Voluntary Donations Meet the State Monopoly: Understanding Blood Shortages in China." China Quarterly 236 (November 12, 2018): 1111–30. http://dx.doi.org/10.1017/s0305741018001327.

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AbstractChina's blood-borne HIV catastrophe in the 1990s prompted the government to adopt a blood-collection system that combines voluntary donations with the state's monopoly on blood services. Juxtaposing fieldwork and survey data, this study examines how the intricate interplay between government manoeuvres and citizen reactions has led to blood shortages that are serious yet manageable. This article reveals that even though voluntary blood donations are adversely affected by a public distrust of state-run collection agencies, owing to political concerns healthcare officials shirk from engaging with citizens to overcome the distrust. It also finds that the blood shortages are nevertheless largely manageable because the authorities have the capacity to recruit captive donors through work units, with the caveat that such captive practices are used sparingly. Overall, this study argues that the lack of state–society synergy in voluntary donations, while exacerbated by government involvement, is also partially remedied by the government's mobilization of captive donors.

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11

Allain, Jean-Pierre, Shirley Owusu-Ofori, Xianlin Ye, Cyrille Bisseye, Mira El Chaar, and Chengyao Li. "Hepatitis B Virus Chronic Infection in Blood Donors from Asian and African High or Medium Prevalence Areas: Comparison According to Sex." Viruses 14, no. 4 (March 24, 2022): 673. http://dx.doi.org/10.3390/v14040673.

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Immune control of various infectious diseases, particularly viral, was shown to be more efficient for females than males. Response to viral vaccines (HAV, HBV) was higher in females. Data on hepatitis B virus (HBV) markers accumulated over 15 years in blood donors was stratified according to sex, including HBsAg, HBV viral load and levels of anti-HBs in areas where genotypes B and C (China), genotype D (Iran, Lebanon, Tunisia) and genotype E (Ghana, Burkina Faso, Gabon) were prevalent. HBsAg was screened by either ELISA or rapid tests, anti-HBc and anti-HBs by ELISA, HBV DNA load by a standardized method across sites. In Ghanaian children less than 5 years, HBV DNA load was significantly lower in females than in males (p = 0.035). In China, Ghana, Burkina Faso and Gabon blood donors, median HBsAg prevalence was ~5% and 3% in China, ~8.5% and 4.5% in Gabon, ~16% and 11% in Burkina Faso and ~11% and 7% in Ghana for male and female donors, respectively (p < 0.001). In HBsAg+ Ghanaian blood donors, distribution and median viral load were not significantly different between sexes; occult hepatitis B infections (OBI) were significantly more frequent in males. In Chinese blood donor anti-HBc+ and anti-HBs+, anti-HBs levels tended to be higher in males but vaccinated donors’ anti-HBs+ only, while anti-HBs levels were females > males. In areas where genotypes B-E are dominant, the prevalence of chronic HBV infection (HBsAg+) seems better controlled before age 16–18 by females infected vertically or horizontally. OBIs appear considerably more frequent in men, suggesting lower efficacy of HBV infection control. Female blood donors appear significantly safer from HBV than males, and their donation should be encouraged.

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12

Cohen, J. "HIV/AIDS IN CHINA: An Unsafe Practice Turned Blood Donors Into Victims." Science 304, no. 5676 (June 4, 2004): 1438–39. http://dx.doi.org/10.1126/science.304.5676.1438.

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13

Ji, Guoping, Roger Detels, Zunyou Wu, and Yueping Yin. "Correlates of HIV infection among former blood/plasma donors in rural China." AIDS 20, no. 4 (February 2006): 585–91. http://dx.doi.org/10.1097/01.aids.0000210613.45212.c4.

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14

Ren, Furong, Chenyan Zhao, Ling Wang, Zhuoyan Wang, Xiaoyan Gong, Meilan Song, Hui Zhuang, et al. "Hepatitis E virus seroprevalence and molecular study among blood donors in China." Transfusion 54, no. 3pt2 (December 24, 2013): 910–17. http://dx.doi.org/10.1111/trf.12530.

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15

Zheng, X., X. Ye, L. Zhang, W. Wang, L. Shuai, A. Wang, J. Zeng, D. Candotti, J. P. Allain, and C. Li. "Characterization of Occult Hepatitis B Virus Infection from Blood Donors in China." Journal of Clinical Microbiology 49, no. 5 (March 16, 2011): 1730–37. http://dx.doi.org/10.1128/jcm.00145-11.

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16

Li, Xin, Zheng Lin, Jiayan Liu, Yuanyuan Tang, Xiaohong Yuan, Nainong Li, Zhenxing Lin, Yuanzhong Chen, and Ailin Liu. "Overall prevalence of human parvovirus B19 among blood donors in mainland China." Medicine 99, no. 17 (April 2020): e19832. http://dx.doi.org/10.1097/md.0000000000019832.

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17

Wang, Xing, Bin He, Zhaoxia Zhang, Tao Liu, Hui Wang, Xu Li, Qiong Zhang, Ke Lan, Xiaomei Lu, and Hao Wen. "Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors." Virology Journal 7, no. 1 (2010): 62. http://dx.doi.org/10.1186/1743-422x-7-62.

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18

Yong-lin, Yang, Fu Qiang, Zhang Ming-shun, Cai Jie, Ma Gui-ming, Huang Zu-hu, and Cai Xu-bing. "Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China." Virology Journal 9, no. 1 (2012): 82. http://dx.doi.org/10.1186/1743-422x-9-82.

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19

Gao, Z., Y. Zhang, Y. Yang, M. Xu, P. Liao, W. He, J. Xu, Y. Liu, and M. He. "Dengue virus infections among blood donors in Guangxi of China, 2013-2014." Transfusion Medicine 28, no. 3 (July 31, 2017): 236–42. http://dx.doi.org/10.1111/tme.12448.

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20

Liu, T. X., Y. C. Liu, L. Ma, F. Zhao, R. Y. Zhang, and L. L. Shi. "Molecular screening of Vel-blood donors using DNA pools in Nanjing, China." Transfusion Medicine 27, no. 6 (September 7, 2017): 457–59. http://dx.doi.org/10.1111/tme.12460.

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21

Huang, J., Q. You, D. Song, X. Rong, C. Li, and Y. Fu. "Update on epidemiology of hepatitis B virus among blood donors in China." ISBT Science Series 13, no. 3 (April 14, 2018): 359–64. http://dx.doi.org/10.1111/voxs.12432.

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22

Tian, F., J. Wang, Y. Huang, X. Guo, Z. Yun, T. Yang, K. Nelson, G. B. Schreiber, P. Ness, and H. Shan. "Psychological and behavioural impacts of the 2008 China earthquake on blood donors." Vox Sanguinis 99, no. 2 (March 1, 2010): 142–48. http://dx.doi.org/10.1111/j.1423-0410.2010.01320.x.

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23

Zhuang, Wanchuan, Xian Ding, Chun Lyu, Leilei Xiang, Hairong Teng, and Jiaxin Li. "Hepatitis E virus seroprevalence among blood donors in Jiangsu Province, East China." International Journal of Infectious Diseases 26 (September 2014): 9–11. http://dx.doi.org/10.1016/j.ijid.2014.04.022.

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24

Tung, Tran Thanh, Jürgen Schmid, Vu Xuan Nghia, Le Chi Cao, Le Thi Kieu Linh, Ikrormi Rungsung, Bui Tien Sy, et al. "Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors." Pathogens 11, no. 12 (December 13, 2022): 1524. http://dx.doi.org/10.3390/pathogens11121524.

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Occult hepatitis B infection (OBI) is characterized by the presence of low levels of hepatitis B virus (HBV) DNA and undetectable HBsAg in the blood. The prevalence of OBI in blood donors in Asia ranges from 0.013% (China) to 10.9% (Laos), with no data available from Vietnam so far. We aimed to investigate the prevalence of OBI among Vietnamese blood donors. A total of 623 (114 women and 509 men) HBsAg-negative blood donors were screened for anti-HBc and anti-HBs by ELISA assays. In addition, DNA from sera was isolated and nested PCR was performed for the HBV surface gene (S); a fragment of the S gene was then sequenced in positive samples. The results revealed that 39% (n = 242) of blood donors were positive for anti-HBc, and 70% (n = 434) were positive for anti-HBs, with 36% (n = 223) being positive for both anti-HBc and anti-HBs. In addition, 3% of blood donors (n = 19) were positive for anti-HBc only, and 34% (n = 211) had only anti-HBs as serological marker. A total of 27% (n = 170) were seronegative for any marker. Two of the blood donors (0.3%) were OBI-positive and sequencing revealed that HBV sequences belonged to HBV genotype B, which is the predominant genotype in Vietnam.

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25

Lin, Hong. "Current Situation of Transfusion-Transmitted Malaria in China." Journal of Tropical Medicine 2021 (July 8, 2021): 1–7. http://dx.doi.org/10.1155/2021/3970370.

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Although China is moving toward the eradication of malaria and no indigenous malaria has been reported in most Chinese provinces for several years, recent evaluations have revealed that imported cases remain a major challenge to eliminating malaria, with the number of transfusion-transmitted malaria (TTM) cases increasing over time. Here, we review several TTM case reports published after the implementation of the National Malaria Elimination Program in 2010. A total of 12 TTM cases were reported in China between 2013 and 2018. All recipients and donors were diagnosed using rapid diagnosis test and peripheral blood smears. Plasmodium species in donors with low-density parasites were identified using PCR. Nine (75.0%) were identified as Plasmodium falciparum, two (16.7%) were identified as Plasmodium vivax, and one (8.3%) was identified as Plasmodium ovale. All were imported from malaria-endemic areas. New action plans designed to meet the challenges of TTM are necessary to ensure the elimination of malaria in China. Paying more attention to the frequency of TTM could help to enhance blood safety in China.

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26

Dutt, Neeti, Sushil Sharma, and Meena Sidhu. "Study of seroprevalence of antibodies to SARS-COV-2 among the healthy blood donors of Jammu region." International Journal of Research in Medical Sciences 10, no. 2 (January 29, 2022): 495. http://dx.doi.org/10.18203/2320-6012.ijrms20220298.

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Background: SARS‑CoV‑2 emerged in China and spread throughout the world due to its rapid transmission. The exposure rate in the healthy population is unknown, mainly in resource‑limited countries. Herein, we estimated the seroprevalence of anti‑SARS‑CoV‑2 antibodies and risk factors among blood donors at our blood bank and to describe some characteristics of those that test positive. The objective of the study was to measure the levels of IgG antibodies targeting the SARS-CoV2 during the peak period of the COVID-19 pandemic in Jammu State, India to know the magnitude of SARS-CoV-2 exposure, the prevalence of herd immunity in the population.Methods: This is prospective observational study of COVID-19 seroprevalence among blood donors that complied with blood donation protocol. Participation in study was voluntary after taking proper consent on the consent form.Results: A total of 750 random blood donors who voluntarily participated, were enrolled in this study after obtaining their proper consent on the consent form. Out of 750 donors, 287 (38.2%) were positive for IgG antibodies and 463 (61.7%) were negative for IgG antibodies. In our study, male donors (745) outnumbered the female donors but on the other hand female donors showed a higher prevalence of covid antibodies i.e., 60% as compared to male donors i.e., 38% which is a statistically significant difference (p<0.005).Conclusions: A high prevalence of SARS-CoV-2 antibodies was detected among blood donors which indicated a high level of exposure to the virus within the population and development of innate immunity against the virus. This could help us to introduce a protocol of antibody testing in the screening of blood donors to enhance the number of plasma donation cases for the treatment of serious COVID patients.

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27

Shan, Zhengang, Qiao Liao, Jieting Huang, Ru Xu, Min Wang, Ke Huang, Xi Tang, et al. "Low prevalence of human T lymphocyte virus in blood donors in Guangdong, China." Annals of Blood 3 (September 2018): 40. http://dx.doi.org/10.21037/aob.2018.08.03.

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28

Xu, Ting, Zhong-mei Yi, Jun-mei Luo, He-lian Yu, Ya-han Fan, Hua Lu, Shu-ming Zhao, and Tian-lun Jiang. "Prevalence and trends of transfusion-transmittable infections among blood donors in Southwest China." Journal of Public Health 41, no. 1 (January 17, 2018): 55–61. http://dx.doi.org/10.1093/pubmed/fdx189.

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29

Cao, Feng, Xuonling Shi, Yang Ji, Qinhui Ren, Yusen Zhou, and Haitao Wang. "Detection of TT Virus Infection in HCV-Infected Blood Donors from Southwestern China." Vox Sanguinis 78, no. 4 (June 2000): 254. http://dx.doi.org/10.1046/j.1423-0410.2000.78402541.x.

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30

Lin, Hong, Xian Chen, Shaowen Zhu, Ping Mao, Shanshan Zhu, Yanchun Liu, Chengyin Huang, Jun Sun, and Jin Zhu. "Prevalence of Occult Hepatitis C Virus Infection among Blood Donors in Jiangsu, China." Intervirology 59, no. 4 (2016): 204–10. http://dx.doi.org/10.1159/000455854.

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31

Liu, Yong, Ping Li, Cuiping Li, Jinyong Zhou, Chao Wu, and Yi-Hua Zhou. "Detection of hepatitis B virus DNA among accepted blood donors in Nanjing, China." Virology Journal 7, no. 1 (2010): 193. http://dx.doi.org/10.1186/1743-422x-7-193.

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32

Shang, Guifang, Youqing Yan, Baocheng Yang, Chaopeng Shao, Fei Wang, Qian Li, and Clive R. Seed. "Two HBV DNA+/HBsAg− blood donors identified by HBV NAT in Shenzhen, China." Transfusion and Apheresis Science 41, no. 1 (August 2009): 3–7. http://dx.doi.org/10.1016/j.transci.2009.05.001.

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33

Chen, Xiangxiang, Ping Gong, Abram L. Wagner, Yixuan Li, Guanhong Wang, and Yihan Lu. "Identification of hepatitis E virus subtype 4f in blood donors in Shanghai, China." Virus Research 265 (May 2019): 30–33. http://dx.doi.org/10.1016/j.virusres.2019.03.001.

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34

Lau, J. T. F., X. N. Yu, W. W. S. Mak, Y. M. Cheng, Y. H. Lv, and J. X. Zhang. "Suicidal ideation among HIV+ former blood and/or plasma donors in rural China." AIDS Care 22, no. 8 (June 7, 2010): 946–54. http://dx.doi.org/10.1080/09540120903511016.

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35

Mi, Zhiqiang, Ying Lu, Shana Zhang, Xiaoping An, Xiaona Wang, Bin Chen, Quanli Wang, and Yigang Tong. "Absence of xenotropic murine leukemia virus-related virus in blood donors in China." Transfusion 52, no. 2 (August 19, 2011): 326–31. http://dx.doi.org/10.1111/j.1537-2995.2011.03267.x.

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36

Gong, Tianxiang, Xin Zhao, Yijia Luo, Ying Hong, Shuping Li, and Xuemei Fu. "Distribution of hepatitis C virus genotypes in volunteer blood donors from Chengdu, China." Archives of Virology 161, no. 7 (April 21, 2016): 1873–82. http://dx.doi.org/10.1007/s00705-016-2865-0.

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37

Li, Ling, Shanhai Ou, Chengyin Huang, Xueyong Zhou, Hongwei Ge, Jianping Li, Jinfeng Zeng, et al. "The prevalence of human T‐cell leukemia virus in blood donors in China." Transfusion 59, no. 7 (April 15, 2019): 2361–67. http://dx.doi.org/10.1111/trf.15309.

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38

Shi, Ling, Yu Liu, Jingxing Wang, Peibin Zeng, Zhan Gao, Shaoli Wang, Ping Fu, et al. "HIV prevalence and incidence estimates among blood donors in five regions in China." Transfusion 60, no. 1 (December 16, 2019): 117–25. http://dx.doi.org/10.1111/trf.15636.

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39

Yuan, Q., S. H. Ou, C. R. Chen, S. X. Ge, B. Pei, Q. R. Chen, Q. Yan, et al. "Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China." Journal of Clinical Microbiology 48, no. 2 (November 25, 2009): 357–62. http://dx.doi.org/10.1128/jcm.01781-09.

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40

Shi, X. L., Q. H. Ren, Z. Y. Zhu, D. M. Qu, Y. Ji, D. H. Peng, and S. Q. Ni. "Hepatitis C virus infection in blood donors in the People's Republic of China." Transfusion 39, no. 8 (August 1999): 913. http://dx.doi.org/10.1046/j.1537-2995.1999.39080913.x.

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Han, T., C. Li, Y. Zhang, Y. Wang, B. Wu, L. Ke, G. Liu, L. Li, Y. Liu, and Z. Liu. "The prevalence of hepatitis A virus and parvovirus B19 in source-plasma donors and whole blood donors in China." Transfusion Medicine 25, no. 6 (November 13, 2015): 406–10. http://dx.doi.org/10.1111/tme.12259.

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Yue, Qiao-hong, Xian-qing Zhang, Yu Shang, Yao-zhen Chen, Wen-li Sun, Min-quan Su, Shi-jie Mu, Xiao-ke Hao, and Xing-bin Hu. "Anti-HCV reactive volunteer blood donors distribution character and genotypes switch in Xi'an, China." Virology Journal 7, no. 1 (2010): 186. http://dx.doi.org/10.1186/1743-422x-7-186.

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Tu, Yuan-Quan, Min-Jie Wang, Jun Yao, Xiang-Ming Zhu, Pin-Liang Pan, Wen-Ge Xing, Gao-Hong Zhang, Rong-Ge Yang, Yong-Tang Zheng, and Yan Jiang. "Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China." Transfusion 49, no. 9 (May 19, 2009): 1865–73. http://dx.doi.org/10.1111/j.1537-2995.2009.02219.x.

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Mei, Qi, Zhao Wei Ming, Yu Xiu Ping, Jia Ji Hui, Zhou Ya Bin, Wang Hong, Liu Juan, Cheng Yi Zhe, Tang Wei, and Yu Han. "HHV-8 seroprevalence in blood donors and HIV-positive individuals in Shandong area, China." Journal of Infection 55, no. 1 (July 2007): 89–90. http://dx.doi.org/10.1016/j.jinf.2006.10.046.

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Huang, Changhong, Feng Qiu, Minzhuo Guo, Yao Yi, Liping Shen, Feng Wang, Zhiyuan Jia, et al. "Prevalence and risk factors of hepatitis C among former blood donors in rural China." International Journal of Infectious Diseases 16, no. 10 (October 2012): e731-e734. http://dx.doi.org/10.1016/j.ijid.2012.05.1035.

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Chen, Xiulian, Qin Liu, Ping Sun, Shuhui Yuan, Hang Liao, and Xueliang Zhang. "Prevalence of Syphilis Infections Among Volunteer Blood Donors in Jinan Blood Center, China: A 15-Year Retrospective Study." Infection and Drug Resistance Volume 15 (November 2022): 6431–40. http://dx.doi.org/10.2147/idr.s386495.

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Chang, Le, Junpeng Zhao, Fei Guo, Huimin Ji, Lu Zhang, Xinyi Jiang, and Lunan Wang. "Comparative Evaluation and Measure of Accuracy of ELISAs, CLIAs, and ECLIAs for the Detection of HIV Infection among Blood Donors in China." Canadian Journal of Infectious Diseases and Medical Microbiology 2020 (August 14, 2020): 1–9. http://dx.doi.org/10.1155/2020/2164685.

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Abstract:

Background. Enzyme-linked immunosorbent assay (ELISA) is the only serological method approved for blood screening in China. Automated chemiluminescence immunoassay (CLIA) and electrochemiluminescence immunoassay (ECLIA) had been used in clinical laboratories but not applied to screen HIV among blood donors. This study aimed to evaluate the performance of ELISA, CLIA, and ECLIA, focusing on the feasibility of CLIA/ECLIA for blood screening. Method. 1029 blood donations from 14 blood centers screened by ELISA were enrolled in the study. All plasma samples were tested by eight ELISA assays in 16 blood centers, followed by the detection of CLIA and ECLIA methods in the National Center for Clinical Laboratories (NCCL), further confirmed by nucleic acid testing (NAT) and Western blot (WB). Results. Of 1029 samples, 136 were confirmed as HIV positive. CLIA and ECLIA assay had similar sensitivities with ELISAs but showed higher specificity (CLIA: 99.1%, 885/893; ECLIA: 99.0%, 884/893), concordance rate (CLIA: 99.2%, 1021/1029; ECLIA: 99.1%, 1020/1029), and positive predictive value (PPV) (CLIA: 94.4%, 136/144; ECLIA: 93.8%, 136/145) than most of ELISA kits (>5 ELISAs) (P<0.05). Kappa values of CLIA (0.967) and ECLIA (0.963) were the highest among all the serologic assays. Among 451 samples with initial ELISA reactivity, 315 were negatives, of which 307 (97.5%) and 306 (97.1%) were detected as nonreactive by CLIA (8 nonspecific reactions) and ECLIA (9 nonspecific reactions), respectively. Conclusion. Compared with ELISA, CLIA and ECLIA are more specific and accurate in detecting HIV antibody/antigen and can keep more nonspecifically reactive donors detected by ELISA. CLIA and ECLIA can be used for the improvement of serological blood screening strategy to avoid the unnecessary loss of blood donors.

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Liao, Qiao, Zhengang Shan, Min Wang, Jieting Huang, Ru Xu, Tingting Li, Wenjing Wang, Chengyao Li, Xia Rong, and Yongshui Fu. "Prevalence and evolutionary analyses of human T-cell lymphotropic virus in Guangdong province, China: Transcontinental and Japanese subtype lineages dominate the prevalence." PLOS Neglected Tropical Diseases 15, no. 2 (February 4, 2021): e0009043. http://dx.doi.org/10.1371/journal.pntd.0009043.

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To systematically characterize the prevalence and evolution of human T-cell lymphotropic virus (HTLV) infection among voluntary blood donors (BDs) in Guangdong province, China. A three-year survey for HTLV epidemiology among BDs was performed in Guangdong during 2016–2018. Anti-HTLV-1/2 was screened by ELISA and ECLIA, and subsequently confirmed by western blot (WB) and nucleic acid testing (NAT). The prevalence of HTLV in donors from different cities was calculated. The identified HTLV-positive cases were phylogenetically genotyped and analyzed in a Bayesian phylogenetic framework. Among 3,262,271 BDs, 59 were confirmed positive for HTLV-1 (1.81 per 100,000) and no HTLV-2 infection was found. The prevalence of HTLV-1 varied significantly among 21 cities in Guangdong province, China. The highest prevalence was found in donors from Shanwei (13.94 per 100,000), which is a coastal city in eastern Guangdong. Viral genomic sequences genotyped from 55 HTLV-1 carriers showed that 39 were transcontinental subtype and 16 were Japanese subtype. Specially, 13 out of 39 transcontinental subtype sequences were characterized with L55P mutation and 21 out of 55 sequences were characterized with L19F mutation in viral gp46 protein. The L55P mutation seemed be specific to eastern Asia since it only presented in the sequences from Japan, mainland China, and Taiwan. Phylogenetic analysis of gp46 gene shows that HTLV-1a may have been introduced to Guangdong through four different introduction events and formed major transmission clusters: clades I(13,602 years ago), II(16, 010 years ago), III(15,639 years ago) and IV(16,517 years ago). In general, Guangdong is considered to be a low-prevalence region for HTLV-1 infection, but the prevalence is significantly higher in Shanwei city. Transcontinental and Japanese subtype lineages dominate the prevalence in Guangdong. In terms of blood safety, HTLV antibody screening for first-time blood donors can effectively reduce the risk of HTLV transmission.

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Wu, Xiaobing, Yang Guan, Jianbin Ye, Hanlin Fu, Chunlai Zhang, Lina Lan, Fengxin Wu, et al. "Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017." BMJ Open 9, no. 11 (November 2019): e024393. http://dx.doi.org/10.1136/bmjopen-2018-024393.

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ObjectiveThis study investigated the association between syphilis seroprevalence and age among blood donors, and described the distribution of serological titres among syphilis-infected donors, aiming to confirm the syphilis epidemic characteristics and to promote effective interventions for older adults.MethodsData were obtained from the Shenzhen Programme for Syphilis Prevention and Control in 2014–2017. Blood samples were screened using the ELISAs, and confirmed using the Treponema pallidum particle agglutination assay (TPPA) and toluidine red unheated serum test (TRUST).ResultsAmong 394 792 blood donors, 733 tested TPPA and TRUST positive (active infection), and 728 tested only TPPA positive (historical infection). The overall prevalence of syphilis seropositivity was 370.1 per 100 000 (95% CI 351.1 to 389.0 per 100 000); the prevalence of active infection was 185.7 per 100 000 (95% CI 172.2 to 199.1 per 100 000). People aged ≥45 years displayed a prevalence of 621.8 per 100 000 in syphilis seropositivity and 280.5 per 100 000 in active infection, which were 3.8 times and 2.4 times higher than that for people aged <25 years, respectively. The prevalence of syphilis seropositivity (χ2trend=311.9, p trend<0.001) and active infection (χ2trend=72.1, p trend<0.001) increased significantly with age. After stratification by gender and year of donation, the increasing trend of prevalence with age remained (p trend<0.05), except for the prevalence of active infection in males and females in 2014. About 16.3% of donors with active infection and aged ≥45 years had a TRUST titre of ≥1∶8, lower than that of patients aged <25 years (51.3%) and 25–34 years (34.1%).ConclusionsThe findings confirm the high prevalence of syphilis among older adults, and suggest the need to increase awareness among healthcare providers and deliver more targeted prevention interventions for older adults to promote early testing.

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Alberty Martins, Isabel, Ronald Chan Chi Ling, Earnest Lam Chi Fai, Hoo Chai, Mario Augusto do Rosàrio Vong, and Gabriel A. B. de Olim. "Antibodies to Hepatitis C Virus in Blood Donors and Polytransfused Patients of Macau (Southeast China)." Vox Sanguinis 65, no. 3 (1993): 245–46. http://dx.doi.org/10.1159/000462434.

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