Relevant bibliographies by topics / Blood DNA

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Blood DNA'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Blood DNA"

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Filho, Ednaldo da Silva, and Taianara Tocantins Gomes Almeida. "Optimized Protocols for Extraction of DNA in Plant and Blood Tissues." International Journal of Scientific Research 2, no. 11 (June 1, 2012): 57–58. http://dx.doi.org/10.15373/22778179/nov2013/17.

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Fang, Chyang T. "Blood Screening for HBV DNA." Journal of Clinical Virology 36 (May 2006): S30—S32. http://dx.doi.org/10.1016/s1386-6532(06)80006-5.

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Ferec, C., C. Verlingue, and JP Saleum. "HBV DNA in blood donors." Transfusion 28, no. 1 (January 1988): 84–85. http://dx.doi.org/10.1046/j.1537-2995.1988.28188127965.x.

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Brauner, Paul. "DNA Typing and Blood Transfusion." Journal of Forensic Sciences 41, no. 5 (September 1, 1996): 14020J. http://dx.doi.org/10.1520/jfs14020j.

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Kendall, Teresa L., Darryl J. Byerley, and Roger Dean. "Isolation of DNA from blood." Analytical Biochemistry 195, no. 1 (May 1991): 74–76. http://dx.doi.org/10.1016/0003-2697(91)90297-7.

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Reid, Marion E. "From DNA to blood groups." Immunohematology 24, no. 4 (2020): 166–69. http://dx.doi.org/10.21307/immunohematology-2019-293.

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Signer, Esther, Clive C. Kuenzle, Peter E. Thomann, and Ulrich Hübscher. "DNA fingerprinting: improved DNA extraction from small blood samples." Nucleic Acids Research 16, no. 15 (1988): 7738. http://dx.doi.org/10.1093/nar/16.15.7738.

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Jung, Steffen. "DNA-catching BM macrophages set hematopoiesis." Blood 134, no. 16 (August 16, 2019): 1274–75. http://dx.doi.org/10.1182/blood.2019002589.

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Mohamed, T., D. Endoh, and S. Oikawa. " DNA damage of blood lymphocytes and neutrophils in cattle with lymphosarcoma." Veterinární Medicína 56, No. 10 (November 11, 2011): 504–9. http://dx.doi.org/10.17221/3295-vetmed.

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  The objective of the present study was to analyze the apoptotic process in peripheral blood mononuclear cells (PBMC) and polymorphonuclear neutrophil leukocytes (PMN) in cows clinically affected with lymphosarcoma. Thirteen cows were studied. Of them, eight, that were referred because of inappetance, loss of body condition, diarrhoea, constipation, protrusion of third eyelid, and exophthalmia, were seropositive for bovine leukemia virus (BLV) based on a serum enzyme-linked immunosorbent assay. Other animals were apparently healthy and were used as controls. DNA damage of PBMC and PMN was assessed using the Comet assay. The results obtained showed a statistically significant difference in DNA damage between the PBMC and PMN isolated from cows infected with BLV compared to PBMC and PMN isolated from healthy cows. This is the first article to document decreased apoptosis of blood PBMC and PMN in cattle in response to BLV infection using the Comet assay.
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Liang, Fengshan, Adam S. Miller, Carolilne Tang, Patrick Sung, and Gary M. Kupfer. "UAF1 DNA Binding Activity Is Critical for RAD51-Mediated Homologous DNA Pairing." Blood 134, Supplement_1 (November 13, 2019): 2497. http://dx.doi.org/10.1182/blood-2019-130435.

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Background: In the Fanconi anemia (FA) DNA repair pathway, DNA damage induces the mono-ubiquitination of the FANCI-FANCD2 (ID2) heterodimer by the FA core complex through its inherent E3 ligase activity. The timely deubiquitination of ID2 by USP1-UAF1 deubiquitinase complex is also critically important for the FA DNA repair. UAF1 has a DNA binding activity, which is required for FANCD2 deubiquitination. UAF1 also enhances RAD51-mediated homologous DNA pairing in a manner that is dependent on complex formation with RAD51AP1. UAF1 deficient cells are impaired for DNA repair by homologous recombination (HR).The biochemical and cellular functions of UAF1 DNA binding activity in HR remain elusive. Methods:UAF1 wild type and DNA binding mutant proteins were purified and used to define its biochemical properties in HR. In vitroD-loop formation and synaptic complex assembly assay were performed to discover the DNA binding of UAF1 in RAD51 recombinase enhancement. U2OS-DR-GFP cell lines with impaired UAF1 or RAD51AP1DNA binding were generated to examine HR efficiency and DNA damage resistance. Results:UAF1 preferentially binds an HR-intermediate-like DNA substrate (D-loop, Fig.1). The DNA binding deficient mutant of UAF1 is unable to stimulate RAD51AP1 promotion of RAD51-mediated D-loop (Fig. 2) and the ability to recruit homologous DNA to form the presynaptic complex formation in HR (Fig. 3). In cells, the UAF1 DNA-binding mutant is compromised for the ability to repair DNA damage and to implement HR (Fig. 4). Such activity correlates with the ability to confer resistance to DNA cross linking agents such as mitomycin C (Fig. 4). The DNA binding of UAF1 and RAD51AP1 have a coordinated role in HR-directed DNA damage repair (Fig. 5). Conclusions: UAF1 DNA binding activity is indispensable for its function in enhancing RAD51-mediated homologous DNA pairing within the context of the UAF1-RAD51AP1 complex. UAF1 DNA binding deficiency causes DNA damage sensitivity and impairs HR efficiency in cells. Translational Applicability:Our findings reveal a critical role of UAF1 DNA binding in DNA repair and genome maintenance. The identification of UAF1's role in repair will enable targeted efforts to improve molecular approaches for FA therapy. Disclosures No relevant conflicts of interest to declare.
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Dissertations / Theses on the topic "Blood DNA"

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Brennan, Kevin. "Blood DNA methylation biomarkers for breast cancer risk." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/23641.

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Breast cancer is the most common malignancy affecting women worldwide with an average lifetime risk of 12%. Risk is affected by age, family history, genetics, reproductive factors and environmental exposures, however many unknown risk factors may exist. Regular screening, lifestyle advice and preventative therapy may be offered to women at highest risk; however in the absence of high-penetrance mutations, personal breast cancer risk cannot be accurately estimated. Risk biomarkers are therefore required to help improve current risk prediction models. Epigenetic mechanisms control gene expression and genome function, and are influenced by both heritable and environmental factors. DNA methylation, the most widely studied epigenetic mark, is widely deregulated in cancer and cancer precursor lesions; however the contribution to disease risk of DNA methylation variability in normal tissue prior to disease is poorly understood. Several blood DNA methylation markers associated with cancer have been reported, including genome-wide hypomethylation and hypermethylation of the ATM gene associated with breast cancer, however, validation of these associations in samples collected prior to diagnosis (prospectively collected) are required to determine association with breast cancer risk. The aims of this thesis were to 1) validate ATM methylation as a breast cancer risk marker in three nested case-control studies from prospective cohorts; 2) To investigate hypomethylation of LINE1 in the same prospective cohorts and compare this in a metaanalysis with all other published LINE1 data; 3) To investigate potential mechanisms or modifiers of ATM methylation; 4) To perform discovery microarray studies to identify novel DNA methylation markers of breast cancer risk. Herein, we show that ATM hypermethylation showed a 1.9 fold increased risk of breast cancer limited to women in the highest quintile of methylation (OR =1.89 (1.36-2.64), p= 1.64x10-4). There was no evidence of LINE1 methylation associated with cancer risk in the prospective cohort studies. The meta-analysis 3 of LINE1 and other global methylation markers showed little evidence of association with cancer risk for surrogate assays of repetitive elements, but relatively consistent association with cancer risk using HPLC based total methyl-cytosine levels. Investigation of potential modifiers of ATM methylation revealed that methylation was independent of genetic haplotype, but independently associated with age, genotype of the one-carbon metabolism enzyme MTHFR, and serum levels of serum kynurenic acid levels in controls (p=0.02). Surprisingly, ATM methylation was reduced in controls (p= 5.707e-06) and cases (p= 0.008) that had fasted compared to those that had not. The effect of fasting on ATM methylation could be recapitulated by glucose restriction in ex-vivo PBMCs (p=0.046), independent of cell proliferation. Discovery studies to identify novel DNA methylation risk markers were conducted using differential methylation hybridisation and Illumina Infinium HumanMethylayion450 BeadChip microarrays; however, significant associations were not reproducible in validation sample sets. Discussed are prospects and caveats for epigenetics association studies, including the implications of temporal alteration of DNA methylation by environmental exposures, biases associated with genetic influences on DNA methylation, and the potential for investigation of these interactions to better understand the contribution of epigenetics to gene expression and cancer risk.
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Jakubowicz, Piotr Maciej [Verfasser]. "Hydrogels for DNA isolation from blood / Piotr Maciej Jakubowicz." Mainz : Universitätsbibliothek Mainz, 2014. http://d-nb.info/105200380X/34.

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Kikuchi, Hugh. "Cancer gene mutation detection in circulating cell-free DNA in blood." Thesis, University of Warwick, 2018. http://wrap.warwick.ac.uk/104207/.

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Background: Lung cancer is the most common cause of cancer death worldwide and is estimated to account for more than 1,380,000 deaths per year. Lung cancer can be separated into two major histological types: Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC), accounting for approximately 15% and 85% of cases respectively. Epidermal Growth Factor Receptor (EGFR) is a tyrosine-kinase receptor. In NSCLC EGFR overexpression is found in over 80% of cases, and EGFR copy number gain (CNG) or amplification is found in nearly 60% of them. Tumours with EGFR mutations can be treated using anti-EGFR drugs; however currently genetic analysis has to be performed on tissue which is obtained by biopsy. Aims: This project aims to investigate alternative methods of obtaining tumour DNA for genetic analysis, to potentially improve or support the current diagnostic process. This project will investigate both new testing methods (molecular assays) and new sources of tumour DNA (cell free DNA from plasma). Methods: A number of methods were employed during this project. Initially EGFR and KRAS mutation detection was attempted using a novel Peptide Nucleic Acid Polymerase Chain Reaction (PNA-PCR) assay devised by GeneFirst Ltd (Oxford, UK). The second approach utilised custom designed TaqMan Array 384 well plate assays for the detection of EGFR, KRAS, NRAS and BRAF mutations. 40 clinical EDTA blood samples were obtained for the investigation of the use cfDNA for oncogenic mutation detection. Plasma DNA extracted using two automated platforms (Qiagen EZ1 and Promega Maxwell). The extracted DNA was analysed using the Ion Torrent Next Generation Sequencing (NGS) platform. Results: The GeneFirst novel PNA PCR assays appeared to tolerate low concentration FFPE DNA samples but had a very high false positive rate and the endogenous control assay failed regularly (0- 33.3% failure rate over different assay versions). The TaqMan Array assay was very successful at detecting EGFR, KRAS, NRAS and BRAF mutations from FFPE tissue, displaying 97.62% and 94.74% concordance with previously used diagnostic assays (Qiagen Therascreen EGFR RGQ PCR and Thermo Fisher KRAS castPCR). For the automated isolation of cfDNA, the Promega Maxwell instrument gave consistently superior results to the Qiagen EZ1. CfDNA was successfully used to detect oncogenic mutations using both PCR and NGS assays. Conclusion: This project has utilised a number of approaches in order to investigate new approaches for the detection of clinically actionable oncogenic mutations, both in FFPE tissue (obtained through surgery or biopsy) and the relatively new cfDNA analyte. Two PCR techniques were compared using DNA from FFPE tissue, and the TaqMan Array assay was shown to be vastly superior. The TaqMan Array was subsequently adopted as the primary diagnostic assay in UHCW Pathology. CfDNA (despite the limited number of samples) showed great potential as an alternative for tissue for detection actionable cancer mutations. The Ion Torrent Next Generation Sequencing system proved to be the most sensitive and powerful technique of the ones utilised here, and will prove an invaluable asset for future development of this work.
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Wood, Ryan. "Bacteria in Blood: Optimized Recovery of Bacterial DNA for Rapid Identification." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8147.

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Blood stream infections are challenging infections to rapidly diagnose. The current clinical diagnostic methods for blood stream infections require culturing the blood sample prior to identifying the bacteria and any resistance the bacteria may contain. Removing the culturing step from the bacterial identification process of a blood stream infection provides a significant reduction in the processing time. However, eliminating the culturing step shifts the difficulty from processing time to concentration, since clinical concentration levels can be as low as 10 CFU/mL in blood. This dissertation developed and evaluated many aspects of the process required to identify bacteria from a blood stream infection without culturing the bacteria. Two new methods of separating the bacteria from the blood cells were developed: inducing clotting using a centrifugal-sedimentation on a hollow disk, and filtering whole blood. Inducing clotting achieved 69\% bacterial recovery from 7 mLs of whole blood in 117 s. Filtering whole blood achieved 100\% bacterial removal from 5 mLs of whole blood in $\approx 90$ s, but the bacteria were difficult to remove from the filter. Bacterial removal from the filter after blood filtration was also investigated. At a very low bacterial concentration of 200 CFU/mL, a blood lysis solution of 3\% Tween 80 followed by a 3\% Pluronic F108 backflush solution achieved 60\% removal of the bacteria from the filter. In addition to developing two new methods, a previously developed technique using centrifugal-sedimentation on a hollow disk underwent a stability analysis in order to decrease the occurrence of mixing. This analysis yielded the development of the analytical solution to the Navier-Stokes equations for a two-fluid flow with a moving wall boundary and a free surface. The analysis also experimentally identified a stability boundary that was found to be in good agreement with the Kelvin-Helmholtz instability model. After exploring the methods to recover bacteria from blood, experiments were performed to identify a bacterial lysing solution that could lyse \textit{E. coli}, \textit{E. cloacae} and \textit{K. pneumoniae} bacteria. The best bacterial lysing solution consisted of incubating the bacteria with 1 mg/mL lysozyme for 10 min followed by the addition of 6 M GHCl and 1\% SDS. This solution obtained a 46\% DNA recovery. The DNA were then fragmented by ultrasound to reduce the segment length for DNA labelling. In addition to lysing and fragmenting the DNA, a microfluidic device was prototyped and tested for incorporating the lysing, capturing, releasing, and fragmenting of the DNA all on a single device. Whole experiments were performed which extracted the bacteria from the blood, removed and collected the DNA from the bacteria, and fragmented the DNA. The best overall recovery from an experiment performing the whole process was 26.8\%. The 26.8\% recovery was achieved with a 68\% recovery of the bacteria from spinning and a 54.1\% removal of bacteria from off of the filter and a 72.9\% recovery of the DNA from the bacteria.
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van, der Watt George Frederick. "Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/2705.

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Background: Nucleoside reverse transcriptase inhibitors (NRTIs) interfere with mitochondrial DNA polymerase gamma causing significant toxic effects, including fatal lactic acidosis. Little is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a lifetime exposure to these agents. We performed a cross sectional observation of mtDNA levels in whole blood in a pediatric population to ascertain the relationship between mtDNA, NRTI regimens and parameters of HIV-infection severity. Methods: Whole blood mt:nDNA ratios were determined by real-time PCR in three groups: 27 presumed HIV-negative, 89 HIV-infected, NRTI-treated and 62 HIV-infected treatment-naive children. Multivariate analysis was used to identify variables independently associated with mtDNA depletion. Results: Mean mt:nDNA ratios were lower (P < 0.001) at 77% of control in the HIVinfected antiretroviral treatment (ART) Naïve group and 73% of control in the ART group, but not different between the two HIV-infected groups. Mt:nDNA ratios were negatively associated with age (P = 0.029), HIV status (P < 0.0001) and Log10 of the HIV-1 viral load (P = 0.035) and positively associated with CD4 % (p = 0.032). A 6 stavudine vs zidovudine based regimen was associated with lower but not significant levels of mtDNA (P = 0.1). Conclusions: Depletion of whole blood mtDNA in children is associated independently with HIV-infection and markers of HIV infection severity, and does not improve with either stavudine or zidovudine based ART despite virological control, suggesting that these agents also deplete mtDNA.
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Folkesson, Carl, and Ola Christensson. "Genotypning av laktostolerans (LCT-13910C>T) direkt på blod med realtids-PCR : Utvärdering av Kapa Probe Force." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för naturvetenskap och biomedicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-30807.

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Hos vuxna individer förekommer två fenotyper gällande produktionen av laktas, vilka kallas laktostolerans och laktosintolerans. Vid laktosintolerans produceras otillräckliga mängder laktas vilket framkallar symptom som magsmärtor och flatulens vid intagandet av mjölkprodukter. En enbaspolymorfism (LCT-13910C>T) har kopplats till laktostolerans hos nordvästeuropéer och kan genotypas med smältkurveanalys i realtids-PCR. På Laboratoriemedicin vid Länssjukhuset Ryhov används idag en metod vid genotypning av LCT-13910C>T där extraktion av DNA från blod krävs innan analys. Anledningen till detta är att DNA-polymeraset som ingår enzymmixen LightCycler® FastStart DNA Master HybProbe endast fungerar med rent DNA-templat. Med en annan enzymmix, Kapa Probe Force, ska analys kunna göras direkt på blod. För att utvärdera enzymmixen jämfördes resultat från befintlig metod och resultat från metod med Kapa Probe Force, gällande förmågan att identifiera genotyperna LCT-13910C/C, C/T och T/T samt med avseende på imprecision. Vid jämförelse mellan metoderna samstämde resultatet i avseende på genotyp till 100 % utifrån specificerade smälttemperaturer (Tm) för respektive genotyp angivna i kitet för primer/prober. Däremot syntes lägre fluorescensnivå på smältopparna i metod med Kapa Probe Force, men påverkade inte tolkning av smältkurvorna. En lägre prov-till-prov-variation sågs även i resultatet från metod med Kapa Probe Force gentemot befintlig metod.
Among adults two phenotypes are found with regards to production of lactase, these are termed lactase persistence and lactose intolerance. Lactose intolerance is characterized by a low production of lactase, which leads to symptoms such as stomach ache and flatulence after the consumption of dairy products. A single nucleotide polymorphism (LCT-13910C>T) has been correlated with the occurrence of lactase persistence in northwestern Europeans. Genotyping of LCT-13910C>T is possible with melting curve analysis in real time PCR. The currently used method for genotyping of LCT-13910C>T at Ryhov County Hospital requires the extraction of DNA template from blood, due to the fact that the DNA-polymerase in the kit LightCycler® FastStart DNA Master HybProbe requires pure DNA template for analysis. With another DNA-polymerase, included in the kit Kapa Probe Force, analysis on crude samples such as pure blood should be possible. Evaluation of Kapa Probe Force included comparison of the results from both methods with regards to identification of genotypes LCT-13910C/C, C/T and T/T and with regard to imprecision. The results from Kapa Probe Force were 100 % consistent with the results from existing method and acquired melting temperatures (Tm) were all within the accepted ranges specified in the kit of primers and probes. The fluorescence of melting curves acquired with Kapa Probe Force was significantly lower, however this had no effect when it came to interpreting the results. A lower variation could also be seen between samples with Kapa Probe Force compared to existing method.
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Hagardson, Karin. "Comparison of DNA isolation methods to detect Leishmania parasites in blood samples." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7014.

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Leishmaniasis is a disease affecting more than 12 million people worldwide. It is caused by the protozoan parasite Leishmania, which is transmitted to humans and dog hosts through bites of infected sand flies belonging to genus Phlebotomine. Several studies have shown Polymerase Chain Reaction (PCR) to be effective for the diagnosis of VL in clinical samples compared to the classical methods. The aims of this study were first to compare four different sample preparation methods for the PCR diagnosis of visceral leishmaniasis (VL) using peripheral blood samples and furthermore to find a method that is sensitive, rapid, cost benefit, simple and easy to perform. Two preparation methods were compared for the isolation of leukocytes (with Ficoll and Tris –EDTA buffer) and two DNA isolation methods (with Proteinase K and QIAgen kit). From the methods that were compared, lysis of erythrocytes with TE and the QIAgen kit seems to be the most suitable to use.

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Rai, Saroj. "Viral inactivation using DNA intercalators and dyes for sterilization of blood products /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487779120908841.

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Andersson, Rebecca. "An Evaluation of Two Presumptive Blood Tests and Three Methods to Visualise Blood." Thesis, Linköpings universitet, Biologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139740.

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The aim of this study was to validate the two presumptive blood tests LMG, LCV and the three visualising blood methods Bluestar Forensics, Lumiscene and the Ruhoff method. The methods’ sensitivity, durability, matrices effects, false positive results and the methods effect on subsequent DNA analysis were studied. DNA analyses were also performed to assess the detection limit of the forensic DNA analysis. Drops of diluted blood were applied on different absorptive matrices and the sensitivity was investigated. The solutions were also placed under different conditions to investigate the durability of the solutions. The solutions were applied upon panels using different chemicals and materials and the false positive results were studied. The DNA analyses were performed by diluting the blood with Bluestar Forensics, the hydrogen peroxide method, the Ruhoff method and deionised water. The study showed that the LMG with a 3 % H2O2 concentration performs the best and it is suited for practical casework. The positive results of LMG was easier to interpret than those of LCV, this is probably due to the fixative agent of the used LCV solution. Bluestar Forensics and Lumiscene did perform similar on the different matrices tested, but the Lumiscene solution had a slightly higher durability. The results strongly indicate that the Ruhoff method can be used without luminol, hence only as a hydrogen peroxide solution (the hydrogen peroxide method). All three visualising blood methods decreases chances of retrieving a positive DNA profile, however the visualising blood methods could be used if the blood cannot be found in any other way. A DNA profile was obtained from the one blood sample analysed at dilution of 1:256 in deionized water.
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Cool, Deborah E. "Characterization of the human factor XII (Hageman factor) CDNA and the gene." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26980.

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A human liver cDNA library was screened by colony hybridization with two mixtures of synthetic oligodeoxyribonucleotides as probes. These oligonucleotides encoded regions of β-factor Xlla as predicted from the amino acid sequence. Four positive clones were isolated that contained DNA coding for most of factor XII mRNA. A second human liver cDNA library was screened by colony hybridization with ³²P-labeled cDNA clones obtained from the first screen and two identical clones were isolated. DNA sequence analysis of these overlapping clones showed that they contained DNA coding for the signal peptide sequence, the complete amino acid sequence of plasma factor XII, a TGA stop codon, a 3' untranslated region of 150 nucleotides, and a poly A⁺ tail. The cDNA sequence predicts that plasma factor XII consists of 596 amino acid residues. Within the predicted amino acid sequence of factor XII, were identified three peptide bonds that are cleaved by kallikrein during the formation of β-factor Xlla. Comparison of the structure of factor XII with other proteins revealed extensive sequence identity with regions of tissue-type plasminogen activator (the epidermal growth factor-like region and the kringle region) and fibronectin (type I and type II homologies). As the type II region of fibronectin contains a collagen-binding site, the homologous region in factor XII may be responsible for the binding of factor XII to collagen. The carboxyl-terminal region of factor XII shares considerable amino acid sequence homology with other serine proteases including trypsin and many clotting factors. A human genomic phage library was screened by using a human factor XII cDNA as ahybridization probe. Two overlapping phage clones were isolated which contain the entire human factor XII gene. DNA sequence and restriction enzyme analysis of the clones indicate that the gene is approximately 12 kbp in size and is comprised of 13 introns and 14 exons. Exons 3 through 14 are contained in a genomic region of only 4.2 kbp with introns ranging in size from 80 to 554 bp. The multiple regions found in the coding sequence of FXII that are homologous to putative domains in fibronectin and tissue-type plasminogen activator are contained on separate exons in the factor XII gene. The intron/exon gene organization is similar to the serine protease gene family of plasminogen activators and not to the clotting factor family. Analysis of the 5' flanking region of the gene shows that it does not contain the typical TATA and CAAT sequences found in other genes. This is consistent with the finding that transcription of the gene is initiated at multiple start sites.
Medicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate
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Books on the topic "Blood DNA"

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Blood doctrine: A novel. Littleton, CO: Square Core Media, 2014.

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Shumin, Zhao, and Liu Yan, eds. DNA jian ding qian yan. Beijing: Ke xue chu ban she, 2011.

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Rainis, Kenneth G. Blood & DNA evidence: Crime-solving science experiments. Berkeley Heights, N.J: Enslow Publishers, 2006.

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Bugert, Peter, ed. DNA and RNA Profiling in Human Blood. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-553-4.

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Latta, Sara L. DNA and blood: Dead people do tell tales. Berkeley Heights, NJ: Enslow Publishers, 2012.

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The sacred blood. London: Pocket, 2009.

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Byrnes, Michael. The sacred blood. Pymble, NSW: HarperCollins e-books, 2009.

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Commission, Scottish Law. Evidence: Blood group tests, DNA tests and related matters. [Edinburgh: The Commission], 1988.

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Commission, Scottish Law. Evidence: Blood Group tests, DNA tests and related matters. Edinburgh: Scottish Law Commission, 1988.

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David, Pearl, ed. Blood testing, AIDS, and DNA profiling: Law and policy. Bristol [England]: Family Law, 1990.

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Book chapters on the topic "Blood DNA"

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Davis, Heather L., and Cynthia L. Brazolot Millan. "DNA-Based Immunization." In Blood Cell Biochemistry, 351–76. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4889-8_14.

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Benz, E. J. "Introduction to Molecular Genetics and Recombinant DNA Technology." In Biotechnology in blood transfusion, 15–32. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1761-6_2.

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Bartlett, John M. S., and Anne White. "Extraction of DNA from Whole Blood." In PCR Protocols, 29–31. Totowa, NJ: Humana Press, 2003. http://dx.doi.org/10.1007/978-1-4612-0055-0_6.

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Tannenbaum, Steven R., and Paul L. Skipper. "Blood Proteins as Carcinogen Dosimeters." In Mechanisms of DNA Damage and Repair, 473–78. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4615-9462-8_49.

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Dahme, M., W. Seidel, G. Flunker, A. Peters, S. Wiersbitzky, and H. Reddemann. "Detection of Adenoviruses in Blood by Polymerase Chain Reaction." In Methods in DNA Amplification, 179–84. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2530-1_21.

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Petibone, Dayton M., James D. Tucker, and Suzanne M. Morris. "Chromosome Painting of Mouse Peripheral Blood and Spleen Tissues." In Genotoxicity and DNA Repair, 141–58. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1068-7_8.

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Manage, Dammika P., and Linda M. Pilarski. "Miniaturized Technology for DNA Typing: Cassette PCR." In Molecular Typing of Blood Cell Antigens, 175–91. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2690-9_15.

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Dash, Hirak Ranjan, Pankaj Shrivastava, and Surajit Das. "Manual Isolation of DNA from Whole Blood." In Springer Protocols Handbooks, 31–37. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0274-4_4.

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Scheithauer, Richard, and Hans-Joachim Weisser. "Extraction of DNA from Coagulated Blood Samples." In Advances in Forensic Haemogenetics, 169–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77324-2_49.

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Cigliero, Solange Sorçaburu, Elisabetta Edalucci, and Paolo Fattorini. "DNA Extraction from Blood and Forensic Samples." In Guidelines for Molecular Analysis in Archive Tissues, 45–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-17890-0_10.

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Conference papers on the topic "Blood DNA"

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Patnala, Bharathi Devi, and Kiran Kumar Reddi. "DNA cryptography…life blood for new ERA computers." In 2017 International Conference on Energy, Communication, Data Analytics and Soft Computing (ICECDS). IEEE, 2017. http://dx.doi.org/10.1109/icecds.2017.8389627.

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Stern, Marc-Henri, Amanda B. Silveira, Ivan Bieche, Samia Melaabi, Luc Cabel, Bruno Buecher, Jean-Yves Pierga, Francois-Clement Bidard, and Charlotte Proudhon. "Abstract 4599: Detecting MSI phenotype in circulating blood DNA." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4599.

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Tekutskaya, E. E., and I. S. Raybova. "OXIDATIVE DAMAGE TO DNA, IONIZING RADIATION AND MAGNETIC FIELDS." In International conference New technologies in medicine, biology, pharmacology and ecology (NT +M&Ec ' 2020). Institute of information technology, 2020. http://dx.doi.org/10.47501/978-5-6044060-0-7.21.

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In this work, we studied the mechanisms of damage to the structure of DNA extracted from human whole blood after exposure to blood samples of various types of ionizing radiation and a lowfrequency magnetic field. Oxidative damage of nitrogenous bases and single-stranded DNA breaks are caused by the formation of reactive oxygen species generated by radiation.
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Bergens, Matthew A., Gary S. Pittman, Isabel J. Thompson, Michelle R. Campbell, Xuting Wang, Ma Wan, Cathrine Hoyo, and Douglas A. Bell. "Abstract 599: Smoking-associatedAHRRdemethylation in cord blood DNA: Impact of CD235a+ nucleated red blood cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-599.

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Bergens, Matthew A., Gary S. Pittman, Isabel J. Thompson, Michelle R. Campbell, Xuting Wang, Ma Wan, Cathrine Hoyo, and Douglas A. Bell. "Abstract 599: Smoking-associatedAHRRdemethylation in cord blood DNA: Impact of CD235a+ nucleated red blood cells." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-599.

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Li, Dongguang. "DNA Microarray Expression Analysis and Data Mining for Blood Cancer." In 2008 International Seminar on Future BioMedical Information Engineering (FBIE). IEEE, 2008. http://dx.doi.org/10.1109/fbie.2008.68.

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Browne, Cecille D., Margrith E. Mattmann, Marc J. Wycoco, Sheila N. Chen, Rajeswari Ravichandran, Joel Desharnais, Laura J. Varela, Jonathan D. Browne, Vasco Liberal, and Florence Lee. "Abstract 2758: Comparison of cell-free DNA blood collection tubes." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2758.

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Lucia, Rachel McFarland, Wei-Lin Huang, Andrea Alvarez, Irene Masunaka, Argyrios Ziogas, Deborah Goodman, Andrew O. Odegaard, Trina M. Norden-Krichmar, and Hannah Lui Park. "Abstract 3661: Association of mammographic density with blood DNA methylation." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3661.

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Lubecka-Pietruszewska, Katarzyna, Lucinda Kurzava, Hannah Buvala, Kirsty Flower, Samer Gawrieh, Jennifer Mansfield, Naga Chalasani, James M. Flanagan, and Barbara Stefanska. "Abstract 2959: Differential DNA methylation in peripheral blood DNA as a biomarker of hepatocellular carcinoma risk." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2959.

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Konorova, Irina. "CELL-FREE DNA IN THE MECHANISMS OF CEREBRAL BLOOD FLOW REGULATION." In XV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m436.sudak.ns2019-15/231-232.

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Reports on the topic "Blood DNA"

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Reisfeld, Ralph A. An Oral DNA Vaccine Encoding Endoglin Eradicates Breast Tumors by Blocking Their Blood Supply. Fort Belvoir, VA: Defense Technical Information Center, May 2006. http://dx.doi.org/10.21236/ada455983.

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Xiang, Rong. Blocking Blood Supply to Breast Carcinoma with a DNA Vaccine Encoding VEGF Receptor-2. Fort Belvoir, VA: Defense Technical Information Center, March 2003. http://dx.doi.org/10.21236/ada426547.

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Xiang, Rong. Blocking Blood Supply to Breast Carcinoma With a DNA Vaccine Encoding VEGF Receptor-2. Fort Belvoir, VA: Defense Technical Information Center, April 2005. http://dx.doi.org/10.21236/ada435113.

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Xiang, Rong. Blocking Blood Supply to Breast Carcinoma with a DNA Vaccine Encoding VEGF Receptor-2. Fort Belvoir, VA: Defense Technical Information Center, April 2004. http://dx.doi.org/10.21236/ada422420.

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Reisfeld, Ralph A. An Oral DNA Vaccine Encoding Endoglin Eradicates Breast Tumors by Blocking Their Blood Supply. Fort Belvoir, VA: Defense Technical Information Center, May 2007. http://dx.doi.org/10.21236/ada474671.

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Kline, Margaret C., and David L. Duewer. Evaluation of methods for assessing the proportion of single-stranded nuclear DNA in human blood extracts. Gaithersburg, MD: National Institute of Standards and Technology, May 2019. http://dx.doi.org/10.6028/nist.sp.1200-27.

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Wang, Xian. Blood DNA methylation and Type 2 Diabetes Mellitus: a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0136.

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Savova, Gergana, Katya Stankova, Nevena Aneva, and Rayna Boteva. Geldanamycin, Natural Benzoquinone and Inhibitor of the Molecular Chaperone Hsp90, Accelerates the Repair of DNA Doublestrand Breaks in Human Blood Cells. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, May 2021. http://dx.doi.org/10.7546/crabs.2021.05.08.

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