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Academic literature on the topic 'Bladder disease'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Bladder disease"

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Yu, Zhenyuan, Jinling Liao, Yang Chen, Chunlin Zou, Haiying Zhang, Jiwen Cheng, Deyun Liu, et al. "Single-Cell Transcriptomic Map of the Human and Mouse Bladders." Journal of the American Society of Nephrology 30, no. 11 (August 28, 2019): 2159–76. http://dx.doi.org/10.1681/asn.2019040335.

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BackgroundHaving a comprehensive map of the cellular anatomy of the normal human bladder is vital to understanding the cellular origins of benign bladder disease and bladder cancer.MethodsWe used single-cell RNA sequencing (scRNA-seq) of 12,423 cells from healthy human bladder tissue samples taken from patients with bladder cancer and 12,884 cells from mouse bladders to classify bladder cell types and their underlying functions.ResultsWe created a single-cell transcriptomic map of human and mouse bladders, including 16 clusters of human bladder cells and 15 clusters of mouse bladder cells. The homology and heterogeneity of human and mouse bladder cell types were compared and both conservative and heterogeneous aspects of human and mouse bladder evolution were identified. We also discovered two novel types of human bladder cells. One type is ADRA2A+ and HRH2+ interstitial cells which may be associated with nerve conduction and allergic reactions. The other type is TNNT1+ epithelial cells that may be involved with bladder emptying. We verify these TNNT1+ epithelial cells also occur in rat and mouse bladders.ConclusionsThis transcriptomic map provides a resource for studying bladder cell types, specific cell markers, signaling receptors, and genes that will help us to learn more about the relationship between bladder cell types and diseases.
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Jones, Emily, John Alawneh, Mary Thompson, Chiara Palmieri, Karen Jackson, and Rachel Allavena. "Predicting Diagnosis of Australian Canine and Feline Urinary Bladder Disease Based on Histologic Features." Veterinary Sciences 7, no. 4 (November 27, 2020): 190. http://dx.doi.org/10.3390/vetsci7040190.

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Anatomic pathology is a vital component of veterinary medicine but as a primarily subjective qualitative or semiquantitative discipline, it is at risk of cognitive biases. Logistic regression is a statistical technique used to explain relationships between data categories and outcomes and is increasingly being applied in medicine for predicting disease probability based on medical and patient variables. Our aims were to evaluate histologic features of canine and feline bladder diseases and explore the utility of logistic regression modeling in identifying associations in veterinary histopathology, then formulate a predictive disease model using urinary bladder as a pilot tissue. The histologic features of 267 canine and 71 feline bladder samples were evaluated, and a logistic regression model was developed to identify associations between the bladder disease diagnosed, and both patient and histologic variables. There were 102 cases of cystitis, 84 neoplasia, 42 urolithiasis and 63 normal bladders. Logistic regression modeling identified six variables that were significantly associated with disease outcome: species, urothelial ulceration, urothelial inflammation, submucosal lymphoid aggregates, neutrophilic submucosal inflammation, and moderate submucosal hemorrhage. This study demonstrated that logistic regression modeling could provide a more objective approach to veterinary histopathology and has opened the door toward predictive disease modeling based on histologic variables.
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Giridharan, Bhanumati, and Madhivadhanam Madhivadhanam. "Clinical analysis on Gall Bladder Disease Cholecystitis and Cholelitheasis." Scholars Journal of Applied Medical Sciences 4, no. 7 (July 2016): 2480–83. http://dx.doi.org/10.21276/sjams.2016.4.7.36.

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David, Rowan, Luke Traeger, and Christopher McDonald. "Gall bladder torsion: a disease of the elderly." BMJ Case Reports 12, no. 10 (October 2019): e227324. http://dx.doi.org/10.1136/bcr-2018-227324.

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We describe the case of a gall bladder torsion in an elderly female patient, which was discovered during laparoscopic exploration for presumed acute cholecystitis. The rising incidence of this relatively uncommon process can be attributed to increasing life expectancy. Gall bladder torsion typically manifests in septuagenarians and octogenarians of the female gender, as seen in the presented case. It is thought that local mesenteric redundancy predisposes to the development of mechanical organoaxial torsion along the gall bladder’s longitudinal axis involving the cystic duct and artery. Clinicians must have a high index of suspicion for gall bladder torsion, as a mimicker of acute cholecystitis, in the described patient demographic. Preoperative diagnosis is challenging with the vast majority of reported cases being diagnosed intraoperatively, and only five cases preoperatively. Prompt surgical intervention results in an overall mortality rate of approximately 5%, while a delay in diagnosis can lead to catastrophic patient outcomes.
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Peters, C. A., M. R. Freeman, C. A. Fernandez, J. Shepard, D. G. Wiederschain, and M. A. Moses. "Dysregulated proteolytic balance as the basis of excess extracellular matrix in fibrotic disease." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 6 (June 1, 1997): R1960—R1965. http://dx.doi.org/10.1152/ajpregu.1997.272.6.r1960.

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To investigate mechanisms of tissue fibrosis, we developed a model of ovine fetal bladder fibrosis due to surgically induced obstruction. Tissues were analyzed for matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). Active MMP-2 was not detected in obstructed bladders, while latent and active forms were detected in normal bladders. MMP-1 (interstitial collagenase) activity was lower in obstructed bladders. MMP inhibitory activity was increased with obstruction, as were levels of TIMP mRNA and protein. These results indicate that the proteins responsible for collagen degradation are present in the developing bladder, and a shift in the proteolytic balance favoring inhibition of degradation occurs in a model of obstruction-induced fibrosis. This altered proteolytic balance favors accumulation of extracellular matrix and decreased tissue compliance characteristic of this and perhaps other fibrotic conditions.
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Scremin, Luciano Henrique Gazoni, Carlos Eduardo Pereira Corbett, Márcia Dallastra Laurenti, Elizabeth Visone Nunes, Joaquim José Gama-Rodrigues, and Masayuki Okumura. "Megabladder in experimental Chagas disease: pathological features of the bladder wall." Revista do Hospital das Clínicas 54, no. 2 (April 1999): 43–46. http://dx.doi.org/10.1590/s0041-87811999000200003.

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Mega-organs, primarily in the digestive tract, are well known to occur in chronic Chagas disease. Acute experimental infection with Trypanosoma cruzi results in parasitism of a wide range of cells, tissues, and organs, including the urinary bladder. Infection of BALB/c mice with 100,000 bloodstream forms of the Y strain of T. cruzi induced acute infection with intense parasitism of all layers of the urinary bladder. Parasites were found in the mucosa, lamina propria, muscular, adventitial connective, and fat tissue. Desquamate epithelial cells with amastigotes in the bladder lumen were also found. After 60 days of infection, mice inoculated with 50 bloodstream forms developed dilated, thin-walled bladders that had inflammatory infiltrates and foci of fibrosis replacing areas of damaged muscular layer. These lesions result from direct damage to the muscle fibers by the T. cruzi, leading to myosites, muscle damage, and scarring. Direct damage of paraganglia cells secondary to parasitism, leading to dilatation, damage of muscle fibers, and scarring with replacement of muscular tissue with connective tissue, should also be considered as a cause of functional disturbance of the urinary bladder.
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Li, Huixi, Guiting Lin, and Tom F. Lue. "Potential application of adipose tissue-derived stem cells for urological Disease." Bladder 1, no. 1 (November 4, 2014): 2. http://dx.doi.org/10.14440/bladder.2014.23.

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Shah, Navin C. "Atlas of Bladder Disease." JAMA 304, no. 1 (July 7, 2010): 99. http://dx.doi.org/10.1001/jama.2010.912.

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Speich, John E., Jordan B. Southern, Sheree Henderson, Cameron W. Wilson, Adam P. Klausner, and Paul H. Ratz. "Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction." American Journal of Physiology-Renal Physiology 302, no. 8 (April 15, 2012): F967—F976. http://dx.doi.org/10.1152/ajprenal.00177.2011.

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Detrusor smooth muscle (DSM) contributes to bladder wall tension during filling, and bladder wall deformation affects the signaling system that leads to urgency. The length-passive tension ( L-Tp) relationship in rabbit DSM can adapt with length changes over time and exhibits adjustable passive stiffness (APS) characterized by a L-Tpcurve that is a function of both activation and strain history. Muscle activation with KCl, carbachol (CCh), or prostaglandin E2at short muscle lengths can increase APS that is revealed by elevated pseudo-steady-state Tpat longer lengths compared with prior Tpmeasurements at those lengths, and APS generation is inhibited by the Rho Kinase (ROCK) inhibitor H-1152. In the current study, mouse bladder strips exhibited both KCl- and CCh-induced APS. Whole mouse bladders demonstrated APS which was measured as an increase in pressure during passive filling in calcium-free solution following CCh precontraction compared with pressure during filling without precontraction. In addition, CCh-induced APS in whole mouse bladder was inhibited by H-1152, indicating that ROCK activity may regulate bladder compliance during filling. Furthermore, APS in whole mouse bladder was elevated 2 wk after partial bladder outlet obstruction, suggesting that APS may be relevant in diseases affecting bladder mechanics. The presence of APS in mouse bladder will permit future studies of APS regulatory pathways and potential alterations of APS in disease models using knockout transgenetic mice.
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Bales, Gregory T., Francis H. Straus, II, and Glenn S. Gerber. "Crohn's Disease and Urinary Bladder Mass." Diagnostic and Therapeutic Endoscopy 1, no. 4 (January 1, 1995): 233–36. http://dx.doi.org/10.1155/dte.1.233.

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The presence of a bladder mass in a patient with inflammatory bowel disease poses a diagnostic dilemma. We present the case of a 26-year-old male with a bladder mass who had not previously been diagnosed with Crohn's disease. Initial biopsies of the bladder mass were consistent with inflammatory changes, but superficial transitional cell carcinoma could not be reliably excluded. Subsequent evaluation confirmed the presence of Crohn's disease with bladder involvement, and the patient underwent bowel resection and partial cystectomy. Pathologic evaluation demonstrated Crohn’s disease and no evidence of malignancy. Accurate differentiation of benign and malignant bladder masses in patients with inflammatory bowel disease may be difficult and requires cooperation between pathologists and clinicians.
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Dissertations / Theses on the topic "Bladder disease"

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Welton, Joanne Louise. "Exosomes : a source of novel disease biomarkers in bladder cancer." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54114/.

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The major aim of this thesis was to perform the first ever proteomics study on bladder cancer exosomes. Initially, exosomes were isolated from urine specimens but hypervariable yields and poor sample quality made proteomics analysis challenging. As an alternative approach, exosomes were isolated from HT1376 bladder cancer cells. Exosomes were purified by ultracentrifugation on a sucrose cushion, and preparations verified as high quality by immunoblotting, flow cytometry and electron microscopy. For global proteomics analysis, the sample was solubilised using SDS and DTT and subjected to LC-MALDI-TOF/TOF MS. We identified 353 proteins with high confidence and 63 of these have not previously been identified in other proteomics studies on human exosomes. Overrepresentation analysis demonstrated that the proteome was consistent with that of other exosomes with significant overlap with exosomes of carcinoma origin. Comparisons with the Gene Ontology database also highlighted strong associations with carcinoma of the bladder and other sites. A GeneGo generated protein interaction network highlighted c-Myc as a major node of protein interaction within this dataset. Several MS-identified proteins were confirmed as genuinely exosomally expressed using a combination of immunoblotting, flotation on continuous sucrose gradients, and flow cytometry. Expression was also verified in exosomes from a variety of sources, including urine. The data will aid our understanding of exosome biogenesis and function and may inform the development of urine exosome-based clinical tools in bladder cancer.
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Kim, Yangjin. "Statistical analysis of longitudinal data /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3100054.

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Leckey, Joan Lesley. "Urinary and tumour markers of disease recurrence and prognosis in transitional cell carcinoma of the bladder." Thesis, University of Ulster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310119.

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Vasconcellos, Amanda Leal de [UNESP]. "Diagnóstico de cistite em cães: contribuição dos métodos de avaliação." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/89196.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Os cães podem ser acometidos por diversos tipos de doenças vesicais incluindo cistites, neoplasias e urolitíases, dentre outras. A variedade da etiopatogenia e das formas de apresentação clínica das cistites constitui um fator complicante para o diagnóstico. O presente estudo teve por objetivo evidenciar a importância da inclusão de alguns exames complementares com vistas ao diagnóstico correto das afecções vesicais. Foi realizado um estudo prospectivo para o diagnóstico da condição vesical de 46 animais, machos e fêmeas, selecionados ao acaso dentre os encaminhados para check-up de rotina e os pacientes com algum tipo de sinal ou achado sugestivo de doença vesical. A avaliação consistiu de exame clínico completo e exame específico do trato urinário incluindo urinálise, exame microbiológico da urina por meio de cultura em lâmina e cultura tradicional, e avaliação vesical por meio do exame ultrassonográfico. Os dados foram submetidos à analise estatística descritiva e ao Teste Exato de Fisher para associações. Os resultados evidenciaram que os sinais clínicos e os achados de sedimentoscopia da urina não são específicos, dada a semelhança das manifestações das diversas doenças vesicais. A urocultura e a ultrassonografia vesical foram exames complementares decisivos que possibilitaram o diagnóstico dos casos de cistite bacteriana (n=32) bem como das doenças vesicais coexistentes (n=3) e das doenças vesicais não infecciosas (n=2). Concluiu-se que o exame clínico de rotina, mesmo que a urinálise seja incluída, não é apropriado para diagnosticar doenças vesicais e que a urocultura e o exame ultrassonográfico contribuem de modo decisivo para o diagnóstico correto dos cães com ou sem sinais clínicos de cistite
Dogs can be affected by several types of bladder diseases including cystitis, neoplasia, and urolithiasis, among others. The variety of etiopathology and clinical presentation forms of cystitis is a complicating factor for the diagnosis. The aim of this study was to show the importance of some additional exams inclusion in order to achieve the correct diagnosis for bladder diseases. A prospective study was conducted for bladder condition diagnosis in 46 animals, males and females, taken for random among dogs referred for routine checkup and the patients with some type of signs or finding suggestive of bladder disease. The evaluation included complete clinical exam and specific examination of the urinary tract including urinalysis, urine microbiologic examination by commercially manufactured screening urine culture kit and traditional culture, and ultrasound bladder evaluation. The data were analyzed by descriptive statistic and Fisher’s Exact Text. The results showed that clinical signs and urine sediment findings are nonspecific, given the similarity of the bladder diseases manifestations. The urine culture and bladder ultrasound were decisive additional exams that enable the diagnosis of bacterial cystitis (n=32), as well as of the coexisting bladders diseases (n=3) and non infectious bladder diseases (n=2). It was concluded that the routine clinical examination, even when the urinalysis is included, isn`t appropriated for bladder diseases diagnosis, moreover the urine culture and the ultrasonographyc exam contribute in a decisive way for the correct diagnosis of dogs showing or not clinical signs of cystitis
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Vasconcellos, Amanda Leal de. "Diagnóstico de cistite em cães : contribuição dos métodos de avaliação /." Jaboticabal : [s.n.], 2012. http://hdl.handle.net/11449/89196.

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Orientador: Marileda Bonafim Carvalho
Banca: Angela Akamatsu
Banca: Andrigo Barboza de Nardi
Resumo: Os cães podem ser acometidos por diversos tipos de doenças vesicais incluindo cistites, neoplasias e urolitíases, dentre outras. A variedade da etiopatogenia e das formas de apresentação clínica das cistites constitui um fator complicante para o diagnóstico. O presente estudo teve por objetivo evidenciar a importância da inclusão de alguns exames complementares com vistas ao diagnóstico correto das afecções vesicais. Foi realizado um estudo prospectivo para o diagnóstico da condição vesical de 46 animais, machos e fêmeas, selecionados ao acaso dentre os encaminhados para check-up de rotina e os pacientes com algum tipo de sinal ou achado sugestivo de doença vesical. A avaliação consistiu de exame clínico completo e exame específico do trato urinário incluindo urinálise, exame microbiológico da urina por meio de cultura em lâmina e cultura tradicional, e avaliação vesical por meio do exame ultrassonográfico. Os dados foram submetidos à analise estatística descritiva e ao Teste Exato de Fisher para associações. Os resultados evidenciaram que os sinais clínicos e os achados de sedimentoscopia da urina não são específicos, dada a semelhança das manifestações das diversas doenças vesicais. A urocultura e a ultrassonografia vesical foram exames complementares decisivos que possibilitaram o diagnóstico dos casos de cistite bacteriana (n=32) bem como das doenças vesicais coexistentes (n=3) e das doenças vesicais não infecciosas (n=2). Concluiu-se que o exame clínico de rotina, mesmo que a urinálise seja incluída, não é apropriado para diagnosticar doenças vesicais e que a urocultura e o exame ultrassonográfico contribuem de modo decisivo para o diagnóstico correto dos cães com ou sem sinais clínicos de cistite
Abstract: Dogs can be affected by several types of bladder diseases including cystitis, neoplasia, and urolithiasis, among others. The variety of etiopathology and clinical presentation forms of cystitis is a complicating factor for the diagnosis. The aim of this study was to show the importance of some additional exams inclusion in order to achieve the correct diagnosis for bladder diseases. A prospective study was conducted for bladder condition diagnosis in 46 animals, males and females, taken for random among dogs referred for routine checkup and the patients with some type of signs or finding suggestive of bladder disease. The evaluation included complete clinical exam and specific examination of the urinary tract including urinalysis, urine microbiologic examination by commercially manufactured screening urine culture kit and traditional culture, and ultrasound bladder evaluation. The data were analyzed by descriptive statistic and Fisher's Exact Text. The results showed that clinical signs and urine sediment findings are nonspecific, given the similarity of the bladder diseases manifestations. The urine culture and bladder ultrasound were decisive additional exams that enable the diagnosis of bacterial cystitis (n=32), as well as of the coexisting bladders diseases (n=3) and non infectious bladder diseases (n=2). It was concluded that the routine clinical examination, even when the urinalysis is included, isn't appropriated for bladder diseases diagnosis, moreover the urine culture and the ultrasonographyc exam contribute in a decisive way for the correct diagnosis of dogs showing or not clinical signs of cystitis
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Jackson, Ashley R. "Significance of Renal Urothelium During Development and Disease." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1459778047.

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Sousa, Raimundo Nonato Campos 1952. "Clinical aspects and progression of Parkinson's disease in women with detrusor hyperreflexia = Aspectos clínicos e progressão da doença de Parkinson em mulheres com hiper-reflexia detrusora." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309081.

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Orientador: Elizabeth Maria Aparecida Barasnevicius Quagliato
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Objetivos: Avaliar em mulheres com doença de Parkinson e disfunções urinárias as correlações dos sintomas urinários com os sintomas motores e disfunções mentais. Verificar a prevalência de hiper-reflexia detrusora (HD), bem como analisar em longo prazo a gravidade do desempenho motor, estadiamento de Hoenh-Yahr, habilidades funcionais, funções neuropsicológicas e a magnitude da progressão desses aspectos clínicos e do declínio cognitivo em pacientes com HD. Sujeitos e Métodos: Estudamos uma coorte ambulatorial de sessenta e três (63) pacientes com DP cujos aspectos neurológicos foram avaliados com a utilização das escalas Unified Parkinson's Disease Rating Scale (UPDRS) e a escala de Hoehn-Yahr. As habilidades funcionais foram avaliadas pela escala Schwab & England e a função urológica foi quantificada pela International Prostatic Symptom Scale (IPSS) e qualificada pelo estudo urodinâmico. Foram então categorizados dois grupos: pacientes com e sem HD. Após sete anos os mesmos parâmetros foram reavaliados e a escala Montreal Cognitive Assessment (MoCA)-versão brasileira foi utilizada para o rastreamento neuropsicológico. Resultados: Na avaliação inicial foi constatada correlação positiva entre os sintomas urinários e a gravidade da doença, porém não havia correlação entre a sintomatologia urinária e os sintomas mentais. Sintomas motores, estágio de gravidade da doença e habilidades funcionais eram mais graves em pacientes com HD. Na reavaliação, os grupos não apresentavam diferença quanto à magnitude da progressão dos sintomas motores, do estadiamento da doença e das inabilidades funcionais. Foi observado no grupo com HD maior declínio cognitivo e uma nítida progressão dos escores mentais com risco aumentado para demência. Conclusão: Hiper-reflexia detrusora é um achado urodinâmico frequente em mulheres com DP e embora esteja associada à pior desempenho motor, estágios de maior gravidade da doença e inabilidades funcionais, não é um fator de maior progressão desses aspectos clínicos. Por outro lado as pacientes com HD tiveram, em longa duração, significante progressão da sintomatologia neuropsicológica.O perfil do declínio cognitivo e o risco para demência necessitam ser confirmados em estudos posteriores
Abstract: Objectives: This long-term study in women with Parkinson's disease (PD) and lower urinary tract dysfunctions aimed to verify the correlation of urinary symptoms with the severity of the disease and mental functions. Verify the prevalence of detrusor hiper-reflexia (DH) and analyze the severity of motor symptoms, Hoehn and Yahr stage, functional abilities and neuropsychological functions, as well as analyze the progression of these clinical aspects and cognitive decline in patients with DH. Subjects and Methods: We studied a cohort of sixty-three (63) PD patients whose neurological aspects were evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr scale. Functional abilities were evaluated by Schwab and England scale and the urological function was quantified by International Prostatic Symptom Scale (IPSS) and qualified by urodynamic study. Two groups were then categorized: patients with and without HD. After seven years the same parameters were re-evaluated and the cognitive functions were assessed with the Montreal Cognitive Assessment (MoCA). Results: At baseline a correlation between urinary symptoms and motor dysfunction was verified but no correlation between urinary symptoms and mental symptoms was observed. The severity of motor symptoms, stage of the disease and functional disabilities were significant in patients with DH. In the follow up, the groups were similar in regards to progression of motor symptoms, Hoehn and Yahr stage and functional disabilities. On the other hand, decline in cognitive function and clear progression of mental scores and risk for dementia was observed in the group with DH. Conclusion: Urinary symptoms are correlated with the severity of the Parkinson's disease. Detrusor hyper-reflexia is a frequent urodynamic finding in women with DP and although it is associated with worse motor performance, stage of the disease and functional disabilities, it is not a factor of greater progression of these clinical aspects of the disease. On the other hand, patients with DH had a significant progression of the neuropsychological symptoms and risk of dementia. The profile of cognitive decline and dementia risk need to be confirmed in subsequent prospective studies
Doutorado
Neurologia
Doutor em Ciências Médicas
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Olandoski, Karen Previdi. "Avaliação inicial e evolutiva de crianças com bexiga neurogênica congênita atendidas em ambulatório especializado de um hospital de ensino." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-08092009-095316/.

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INTRODUÇÃO: A bexiga neurogênica é considerada um fator de risco importante para insuficiência renal crônica. A preservação da função renal é um dos principais objetivos do tratamento nefrourológico dos portadores desta doença. OBJETIVOS: Descrever as características demográficas de 58 pacientes com bexiga neurogênica congênita, as características anatômicas e funcionais do trato urinário superior e inferior desta população ao início do seguimento e ao final da coleta dos dados e identificar fatores de risco associados à piora de função glomerular e tubular nesta população, utilizando como marcadores a quantificação do ritmo de filtração glomerular e o desenvolvimento de microalbuminúria e acidose metabólica. MÉTODOS: Estudo retrospectivo de uma coorte de 58 pacientes portadores de bexiga neurogênica congênita com seguimento mínimo de seis meses, matriculados no ambulatório de Disfunções Miccionais da Infância da Unidade de Nefrologia Pediátrica do Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. O período de coleta de dados foi encerrado em janeiro de 2006. Os resultados obtidos no estudo foram descritos por médias e desvios padrões, medianas, valores mínimos e máximos, ou por frequências e percentuais. A comparação entre a avaliação inicial e a final para variáveis quantitativas contínuas foi feita usando-se o teste t de Student para amostras pareadas. A associação entre variáveis dicotômicas foi feita considerando-se o teste exato de Fisher. Para avaliação da evolução dos pacientes e comparação de subgrupos definidos por variáveis dicotômicas, foram construídas curvas de Kaplan-Meier e aplicado o teste de Long-rank. Valores de p<0,05 indicaram significância estatística. RESULTADOS: Das 58 crianças avaliadas, 33 eram do sexo feminino (56,9%). A idade média com que as crianças chegaram ao serviço foi de 4,2±3,5 anos, a média de tempo de seguimento foi de 3,8±3,1 anos. A etiologia predominante de bexiga neurogênica foi mielomeningocele, em 42 dos 58 pacientes (72,4%). O encaminhamento à Unidade ocorreu por infecção urinária em 48 (82,8%) casos, por enurese em 5 (8,6%) e por retenção urinária em 5 (8,6%). Dentre os 49/58 (84,5%) pacientes com ITU de repetição ao início do seguimento, 41/49 (83,7%) pacientes apresentaram melhora no período de seguimento. A hipertensão arterial foi diagnosticada em 11 (19,3%) das crianças na avaliação inicial e em 18 (31%) na avaliação final. A média do RFG inicial foi de 146,7±70,1 mL/1,73m2/min e a média final de 193,6±93,6 mL/1,73m2/min, com p=0,0004. A microalbuminúria estava presente em 20 (54,1%) dos exames na avaliação inicial e em 26 (61,9%) na avaliação final. A acidose metabólica estava presente em 11 (19%) dos exames na avaliação inicial e em 19 (32,8%) na avaliação final. As crianças que chegaram à Unidade de Nefrologia mais precocemente (< 3 anos) foram aquelas que mais apresentaram acidose metabólica no decorrer do acompanhamento (p=0,01). Os pacientes que não tinham acidose metabólica ao final do estudo apresentaram valores menores de Z-escore peso final (p= 0,048), Zescore altura/estatura inicial (p= 0,047) e Z-escore altura/estatura final (p=0,022) com relação aos pacientes do grupo que evoluiu com acidose. CONCLUSÃO: Pacientes com bexiga neurogênica congênita evoluem com acometimento renal glomerular e tubular precoce, cujo manejo demanda acompanhamento por profissional especializado.
INTRODUCTION: Neurogenic bladder is considered an important risk factor for chronic renal failure. In these patients, preservation of renal function is one of the most important goals of nephro-urological treatment. PURPOSE: To describe demographic data of 58 children with congenital neurogenic bladder, the anatomic and functional characteristics of their upper and lower urinary tracts at the beginning of the follow-up and at the end of the data collection period and to identify risk factors associated with worsening of the glomerular and tubular functions using as markers the quantitation of glomerular filtration rate and the development of microalbuminuria and metabolic acidosis. METHODS: Retrospective study of a cohort of 58 children with congenital neurogenic bladder treated at the Voiding Dysfunction Clinic, Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, with a minimum follow-up period of 6 months. The period of data collection ended in January 2006. The obtained results were described as means, standard deviations, medians, minimum and maximum values, or as frequencies and percentages. The comparison between the initial and final evaluations for continuous quantitative variables was done using the Student´s t test for paired samples. The association between dichotomous variables was performed considering the Fisher´s exact test. For evaluation of patients` outcomes and comparison of subgroups defined by dichotomous variables, Kaplan-Meier curves were performed and Long-rank test was applied. P values < 0.05 indicated statistical significance. RESULTS: 58 children were evaluated with 33 females (56,9%). The mean age at presentation to the service was 4.2 ± 3.5 years, the mean follow-up period was 3.8 ± 3.1 years. Myelomeningocele was the leading aetiology, corresponding to 42/58 patients (72.4%). Referral to the service occurred in 48 (82.8%) patients due to urinary tract infection, in 5 (8.6%) due to enuresis and in 5 (8.6%) due to urinary retention. Recurrent urinary tract infections were found in 49/58 patients (84.5%) at the beginning and 41/49 (83.7%) had improvement during the follow-up period. Systemic Hypertension was diagnosed in 11 (19.3%) children at the first visit and in 18 (31%) in the final evaluation. The initial mean glomerular filtration rate was 146.7 ±70.1 mL/1.73m²/min and the final mean was 193.6±mL/1.73m²/min, p = 0.0004. Microalbuminuria was found in 20 (54.1%) samples in the initial evaluation and in 26 (61.9%) in the final evaluation. Metabolic acidosis was present in 11 (19%) samples in the initial evaluation and in 19 (32.8%) in the final assessment. The children who most developed metabolic acidosis during the follow-up period were those who presented earlier to the service (< 3 years of age), p= 0.01. The group of patients that did not present metabolic acidosis at the end of the study had lower values of final weight z-score (p=0.048), initial height/stature z-score (p=0.047) and final height/stature z-score (p=0.022) than the patients of the group that developed acidosis. CONCLUSIONS: Children with congenital neurogenic bladder develop early compromise of renal glomerular and tubular functions and require adequate management by specialized professionals.
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Гньотов, М. І., and О. В. Хабаль. "Оптимізація лікувальної тактики холестерозу жовчного міхура під впливом розувастатину, мосаприду та урсодезоксихолієвої кислоти." Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/54846.

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Захворювання жовчного міхура (ЖМ) за частотою випадків поступаються хіба що атеросклерозу. Раннє виявлення та адекватне лікування холестерозу ЖМ має велике клінічне значення внаслідок можливості позитивно вплинути на перебіг захворювання. Мета: вивчення впливу розувастатину, мосаприду та урсодезоксихолієвої кислоти (УДХК) на перебіг хронічного холециститу та холестерозу жовчного міхура у хворих на ІХС, кардіосклероз та ожиріння.
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Gurung, P. M. S. "The tumour suppressor gene, AIMP3, sensitises bladder cancer to chemo/radiotherapy in vitro and is, with ERCC1, a predictive marker of overall survival in patients treated with radical radiotherapy for muscle-invasive disease." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1461130/.

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Bladder cancer is the second most common urological cancer after prostate cancer and is one of the leading causes of cancer mortality in most western countries. For organ-confined, muscle-invasive disease, the standard of care, in terms of definitive cure, remains radical surgery (cystectomy) with lymphadenectomy. However, survival rates remain poor following supposedly curative treatment. Radical radiotherapy and more recently, multimodality treatment incorporating chemo-radiotherapy, are alternatives which allow bladder preservation in those choosing not to undergo or are unsuitable for radical surgery. However, survival rates following radiotherapy are generally lower relative to radical cystectomy and multimodality treatments can only be offered to select cases in few institutions. Biomarkers which can accurately predict tumour response to radiotherapy or chemotherapy can aid the selection of patients who are likely to respond well to treatment options incorporating radiotherapy and/or chemotherapy, as alternatives to radical cystectomy, in the management of bladder cancer. Such a strategy would allow personalised cancer care with patients likely to benefit from treatments that they are likely to respond well to and concomitantly avoid complications arising from other treatments less likely to benefit them. This thesis investigated the novel tumour suppressor gene, AIMP3 which is involved in the DNA damage response (DDR) pathway following exposure to genotoxic insults such as irradiation and chemotherapy. The expression and cellular localisation of AIMP3 protein was characterised in a panel of bladder cancer cell lines. Expression of AIMP3 was altered by gene knockdown with siRNA transfection and survival outcomes assessed following irradiation and chemotherapy. The predictive value of AIMP3 expression in determining survival outcome of patients with muscle-invasive bladder cancer who had undergone radical radiotherapy, with or without carbogen supplementation, in the BCON trial, was assessed. Prognostic significance was evaluated by interrogating a control cohort of patients who had undergone radical cystectomy and had not had exposure to radiotherapy or either neoadjuvant or adjuvant chemotherapy. Reportedly important DDR proteins, including Mre11, p53 and ERCC1, were also interrogated in the BCON, Radical Cystectomy, Neodjuvant and LaMB trial TMA datasets. Clonogenic survival outcomes following AIMP3 knockdown were also investigated in cisplatin-sensitive (RT112) and cisplatin-resistant (RT112CP) cell lines following cisplatin exposure. Survival outcome, stratified for AIMP3 as well as ERCC1, Mre11 and p53 status, were interrogated in the Neoadjuvant set, which incorporated a cohort of patients who had undergone cisplatin-based neoadjuvant chemotherapy prior to radical treatment. This was validated in a second cohort of patients who had undergone cisplatin-based chemotherapy as part of the LaMB trial.
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Books on the topic "Bladder disease"

1

David, Staskin, ed. Atlas of bladder disease. Philadelphia: Current Medicine Group, 2009.

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Atala, Anthony, and Debra Slade, eds. Bladder Disease, Part A. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-8889-8.

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1958-, Atala Anthony, and Slade Debra, eds. Bladder disease: Research concepts and clinical applications. New York: Kluwer Academic/Plenum Publishers, 2003.

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Schulze, Richard. Healing kidney disease naturally. Marina del Rey, Calif: Natural Healing Publications, 2003.

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Leckey, Joan Lesley. Urinary and tumour markers of disease recurrence and prognosis in transitional cell carcinoma of the bladder. [s.l: The Author], 1997.

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New low fat recipes: Nutritionaltherapy for heart disease, weight control, digestive, gall bladder and pancreas disorders. London: Foulsham, 1986.

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J, Manyak Michael, and Kahn Leonard B, eds. Bladder biopsy interpretation. New York: Raven Press, 1992.

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Wein, Alan J. Overactive bladder in clinical practice. London: Springer, 2007.

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Antonio, Lopez-Beltran, and Bostwick David G, eds. Bladder pathology. Hoboken, N.J: Wiley-Blackwell, 2012.

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1930-, Mackay Bruce, ed. Atlas of bladder pathology. New York: Igaku-Shoin, 1991.

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Book chapters on the topic "Bladder disease"

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Allen, Tara, and Graham F. Greene. "BCG Refractory Disease." In Bladder Cancer, 105–13. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-417-9_11.

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Mehlhorn, Heinz. "Swim Bladder Disease." In Encyclopedia of Parasitology, 2586. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-43978-4_4313.

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Mehlhorn, Heinz. "Swim Bladder Disease." In Encyclopedia of Parasitology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27769-6_4313-1.

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Leung, Alexander K. C., Marcus Schmitt, Christie P. Thomas, Cord Sunderkötter, Meinhard Schiller, Thomas Schwarz, Mark Berneburg, et al. "Bladder Exstrophy." In Encyclopedia of Molecular Mechanisms of Disease, 229–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_3324.

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Gupta, Narmada P., and Anup Kumar. "Endemic Bladder Stones." In Urinary Tract Stone Disease, 239–43. London: Springer London, 2010. http://dx.doi.org/10.1007/978-1-84800-362-0_20.

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Shin, Su-Mi. "Bladder and Urethra Disease." In Radiology Illustrated: Pediatric Radiology, 803–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-35573-8_26.

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Stec, Andrew A., Michael S. Cookson, and Sam S. Chang. "Detection of Extravesical Disease: A Lack of Bladder Cancer Markers." In Bladder Cancer, 55–65. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-417-9_7.

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Antonini, Angelo. "Bladder Dysfunction." In Handbook of Non-Motor Symptoms in Parkinson's Disease, 67–72. Heidelberg: Springer Healthcare UK, 2011. http://dx.doi.org/10.1007/978-1-908517-60-9_7.

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Rohrmann, Dorothea. "The Artificial Urinary Bladder." In Bladder Disease, Part A, 885–93. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-8889-8_56.

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Piert, Morand. "PET Imaging: Advances in the Detection of Locally Advanced and Nodal Disease." In Bladder Cancer, 49–53. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-417-9_6.

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Conference papers on the topic "Bladder disease"

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Aditya Chowdary, Tripuraneni Venkata, and Ramalingam Trivikraman. "IDDF2018-ABS-0045 Incidental gall bladder cancer in laparoscopic cholecystectomy." In International Digestive Disease Forum (IDDF) 2018, Hong Kong, 9–10 June 2018. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-iddfabstracts.81.

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Atteya, W. A., Keshav Dahal, and M. Alamgir Hossain. "Multi-agent system for early prediction of urinary bladder inflammation disease." In 2010 10th International Conference on Intelligent Systems Design and Applications (ISDA). IEEE, 2010. http://dx.doi.org/10.1109/isda.2010.5687208.

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Daniltchenko, Dmitri, Eva Lankenau, Frank Konig, Brian Shay, Gereon Huettmann, Markus D. Sachs, Dietmar Schnorr, and Stefan A. Loening. "In vivo optical coherence tomography in endoscopic diagnostics of bladder disease." In Biomedical Optics 2004, edited by Valery V. Tuchin, Joseph A. Izatt, and James G. Fujimoto. SPIE, 2004. http://dx.doi.org/10.1117/12.530207.

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Taeger, Dirk, Beate Pesch, Bierfreund Kay-Gerald, Christoph Oberlinner, Gabriele Leng, Stenzl Arnulf, Matthias Kluckert, and Thomas Brüning. "0153 Risk of bladder cancer in a cohort of chemical workers." In Eliminating Occupational Disease: Translating Research into Action, EPICOH 2017, EPICOH 2017, 28–31 August 2017, Edinburgh, UK. BMJ Publishing Group Ltd, 2017. http://dx.doi.org/10.1136/oemed-2017-104636.121.

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Smith, Gennifer T., Kristen L. Lurie, Saara A. Khan, Joseph C. Liao, and Audrey K. Ellerbee. "Multilayered disease-mimicking bladder phantom with realistic surface topology for optical coherence tomography." In SPIE BiOS, edited by Robert J. Nordstrom, Jean-Pierre Bouchard, and David W. Allen. SPIE, 2014. http://dx.doi.org/10.1117/12.2036402.

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Yeh, Hsin-Chih, Nirmish Singla, Elizabeth Hernandez, Vandana Panwar, Vitaly Margulis, Payal Kapur, Shahrokh F. Shariat, Wen-Jeng Wu, and Jer-Tsong Hsieh. "Abstract B21: PTRF promotes cell survival and predicts disease progression in upper tract urothelial carcinoma." In Abstracts: AACR Special Conference on Bladder Cancer: Transforming the Field; May 18-21, 2019; Denver, CO. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.bladder19-b21.

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Spagnuolo, Carmela, Maria Russo, Idolo Tedesco, Stefania Moccia, Carmen Cervellera, and Gian Luigi Russo. "Extra Virgin Olive Oil Phenols induce authophagy and apoptosis in human bladder cancer cell lines depending on tumor progression." In The 1st International E-Conference on Antioxidants in Health and Disease. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/cahd2020-08633.

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Maia, Andreia, Javier Martin-Fernandez, Josep Maria Gaya Sopena, Oscar Rodriguez-Faba, Joan Palou Redorta, and Mireia Castillo-Martin. "Abstract B16: AGR2 is a marker of disease progression and a potential therapeutic target in non-muscle invasive bladder cancer." In Abstracts: AACR Special Conference on Bladder Cancer: Transforming the Field; May 18-21, 2019; Denver, CO. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.bladder19-b16.

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Gloeckner, D. Claire, Michael B. Chancellor, and Michael S. Sacks. "Changes in Material Classification of the Urinary Bladder Wall After Spinal Cord Injury." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32523.

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Changes in the mechanical properties of the urinary bladder wall following neurogenic disease or trauma can result in bladder dysfunction. We have recently reported changes in the biaxial mechanical properties of the bladder wall 10 days after spinal cord injury in a rat model [1]. Development of a constitutive model to characterize these changes would facilitate quantitative comparisons and provide the necessary information for organ-level computational modeling. However, before an appropriate constitutive model of the bladder wall can be formulated, its material class must be identified. In the present study, we applied a generalized method for material classification of biaxial mechanical data to our previous data on the urinary bladder wall.
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Abbosh, Phillip H., Uttam Satyal, David Liu, Ilsiya Ibragimova, Lauren Szeto, Benjamin Miron, James Ford, et al. "Abstract B29: Use of deep sequencing of urinary DNA as a biomarker of residual disease status at the time of radical cystectomy." In Abstracts: AACR Special Conference on Bladder Cancer: Transforming the Field; May 18-21, 2019; Denver, CO. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1557-3265.bladder19-b29.

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Reports on the topic "Bladder disease"

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Zhu, Zhihong, Yue Zhuo, Haitao Jin, Boyu Wu, and Zhijie Li. Chinese Medicine Therapies for Neurogenic Bladder after Spinal Cord Injury: A protocol for systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0084.

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Neurogenic bladder (NB), a refractory disease, is characterized by voiding dysfunction of bladder and/or urethra, and spinal cord injury (SCI) is a common cause. Chinese medicine therapies have been applied extensively in the treatment of neurogenic bladder, especially in China, and the results are promising but varying. Thus, the aim of this work is to assess the efficacy and safety of various Chinese medicine therapies for neurogenic bladder after spinal cord injury. Condition being studied: Chinese medicine therapies; Neurogenic bladder after spinal cord injury. Main outcome(s): The primary outcome of our NMA will be measured by overall response rate and urodynamic tests, which includes postvoiding residual urine volume, maximum urinary flow rate, and maximal detrusor pressure.
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Leonardo, Kevin, Doddy Hami Seno, Hendy Mirza, and Andika Afriansyah. Biofeedback Pelvic Floor Muscle Training and Pelvic Electrical Stimulation in Women with Overactive Bladder : A Systematic Review and Meta-analysis of Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0024.

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Review question / Objective: Population : Overactive Bladder, Women; Intervention : Biofeedback assisted PFMT and/or pelvic Electrical Stimulation with non-implanted electrodes (on the skin surface around perianal, intra vaginal or rectal); Comparison : PFMT only / Bladder Training / Life style modification-recommendation; Outcome : Changes in Quality of life, Incontinence Episodes, Number of participant cured/improved. Condition being studied: Overactive Bladder syndrome which has been defined as urinary urgency. It is not life threatening disease, therefore, often ignored by patients, but the effect in daily life can be very bothersome.
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