Academic literature on the topic 'Bitopic'

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Journal articles on the topic "Bitopic"

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Wang, Huiqun, Danni Cao, James C. Gillespie, Rolando E. Mendez, Dana E. Selley, Lee-Yuan Liu-Chen, and Yan Zhang. "Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators." Future Medicinal Chemistry 13, no. 6 (March 2021): 551–73. http://dx.doi.org/10.4155/fmc-2020-0308.

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The modulation and selectivity mechanisms of seven mixed-action kappa opioid receptor (KOR)/mu opioid receptor (MOR) bitopic modulators were explored. Molecular modeling results indicated that the ‘message’ moiety of seven bitopic modulators shared the same binding mode with the orthosteric site of the KOR and MOR, whereas the ‘address’ moiety bound with different subdomains of the allosteric site of the KOR and MOR. The ‘address’ moiety of seven bitopic modulators bound to different subdomains of the allosteric site of the KOR and MOR may exhibit distinguishable allosteric modulations to the binding affinity and/or efficacy of the ‘message’ moiety. Moreover, the 3-hydroxy group on the phenolic moiety of the seven bitopic modulators induced selectivity to the KOR over the MOR.
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Ferrisi, Rebecca, Beatrice Polini, Caterina Ricardi, Francesca Gado, Kawthar A. Mohamed, Giovanna Baron, Salvatore Faiella, et al. "New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2." International Journal of Molecular Sciences 24, no. 3 (January 21, 2023): 2135. http://dx.doi.org/10.3390/ijms24032135.

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Very recently, we have developed a new generation of ligands targeting the cannabinoid receptor type 2 (CB2R), namely JR compounds, which combine the pharmacophoric portion of the CB2R positive allosteric modulator (PAM), EC21a, with that of the CB2R selective orthosteric agonist LV62, both synthesized in our laboratories. The functional examination enabled us to identify JR14a, JR22a, and JR64a as the most promising compounds of the series. In the current study, we focused on the assessment of the bitopic (dualsteric) nature of these three compounds. Experiments in cAMP assays highlighted that only JR22a behaves as a CB2R bitopic (dualsteric) ligand. In parallel, computational studies helped us to clarify the binding mode of these three compounds at CB2R, confirming the bitopic (dualsteric) nature of JR22a. Finally, the potential of JR22a to prevent neuroinflammation was investigated on a human microglial cell inflammatory model.
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Flores-Kim, Josué, and Andrew J. Darwin. "Phage Shock Protein C (PspC) of Yersinia enterocolitica Is a Polytopic Membrane Protein with Implications for Regulation of the Psp Stress Response." Journal of Bacteriology 194, no. 23 (September 28, 2012): 6548–59. http://dx.doi.org/10.1128/jb.01250-12.

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ABSTRACTPhage shock proteins B (PspB) and C (PspC) are integral cytoplasmic membrane proteins involved in inducing theYersinia enterocoliticaPsp stress response. A fundamental aspect of these proteins that has not been studied in depth is their membrane topologies. Variousin silicoanalyses universally predict that PspB is a bitopic membrane protein with the C terminus inside. However, similar analyses yield conflicting predictions for PspC: a bitopic membrane protein with the C terminus inside, a bitopic membrane protein with the C terminus outside, or a polytopic protein with both termini inside. Previous studies ofEscherichia coliPspB-LacZ and PspC-PhoA fusion proteins supported bitopic topologies, with the PspB C terminus inside and the PspC C terminus outside. Here we have used a series of independent approaches to determine the membrane topologies of PspB and PspC inY. enterocolitica. Our data support the predicted arrangement of PspB, with its C terminus in the cytoplasm. In contrast, data from multiple independent approaches revealed that both termini of PspC are located in the cytoplasm. Additional experiments suggested that the C terminus of PspC might be the recognition site for the FtsH protease and an interaction interface with PspA, both of which would be compatible with its newly proposed cytoplasmic location. This unexpected arrangement of PspC allows a new model for events underlying activation of the Psp response, which is an excellent fit with observations from various previous studies.
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Gao, Zhan-Guo, Kiran S. Toti, Ryan Campbell, R. Rama Suresh, Huijun Yang, and Kenneth A. Jacobson. "Allosteric Antagonism of the A2A Adenosine Receptor by a Series of Bitopic Ligands." Cells 9, no. 5 (May 12, 2020): 1200. http://dx.doi.org/10.3390/cells9051200.

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Allosteric antagonism by bitopic ligands, as reported for many receptors, is a distinct modulatory mechanism. Although several bitopic A2A adenosine receptor (A2AAR) ligand classes were reported as pharmacological tools, their receptor binding and functional antagonism patterns, i.e., allosteric or competitive, were not well characterized. Therefore, here we systematically characterized A2AAR binding and functional antagonism of two distinct antagonist chemical classes. i.e., fluorescent conjugates of xanthine amine congener (XAC) and SCH442416. Bitopic ligands were potent, weak, competitive or allosteric, based on the combination of pharmacophore, linker and fluorophore. Among antagonists tested, XAC, XAC245, XAC488, SCH442416, MRS7352 showed Ki binding values consistent with KB values from functional antagonism. Interestingly, MRS7396, XAC-X-BY630 (XAC630) and 5-(N,N-hexamethylene)amiloride (HMA) were 9–100 times weaker in displacing fluorescent MRS7416 binding than radioligand binding. XAC245, XAC630, MRS7396, MRS7416 and MRS7322 behaved as allosteric A2AAR antagonists, whereas XAC488 and MRS7395 antagonized competitively. Schild analysis showed antagonism slopes of 0.42 and 0.47 for MRS7396 and XAC630, respectively. Allosteric antagonists HMA and MRS7396 were more potent in displacing [3H]ZM241385 binding than MRS7416 binding. Sodium site D52N mutation increased and decreased affinity of HMA and MRS7396, respectively, suggesting possible preference for different A2AAR conformations. The allosteric binding properties of some bitopic ligands were rationalized and analyzed using the Hall two-state allosteric model. Thus, fluorophore tethering to an orthosteric ligand is not neutral pharmacologically and may confer unexpected properties to the conjugate.
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Stank, Lars, Annika Frank, Stefanie Hagenow, and Holger Stark. "Talipexole variations as novel bitopic dopamine D2 and D3 receptor ligands." MedChemComm 10, no. 11 (2019): 1926–29. http://dx.doi.org/10.1039/c9md00379g.

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Newitt, John A., Nancy D. Ulbrandt, and Harris D. Bernstein. "The Structure of Multiple Polypeptide Domains Determines the Signal Recognition Particle Targeting Requirement ofEscherichia coli Inner Membrane Proteins." Journal of Bacteriology 181, no. 15 (August 1, 1999): 4561–67. http://dx.doi.org/10.1128/jb.181.15.4561-4567.1999.

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ABSTRACT The signal recognition particle (SRP) targeting pathway is required for the efficient insertion of many polytopic inner membrane proteins (IMPs) into the Escherichia coli inner membrane, but in the absence of SRP protein export proceeds normally. To define the properties of IMPs that impose SRP dependence, we analyzed the targeting requirements of bitopic IMPs that are structurally intermediate between exported proteins and polytopic IMPs. We found that disruption of the SRP pathway inhibited the insertion of only a subset of bitopic IMPs. Studies on a model bitopic AcrB-alkaline phosphatase fusion protein (AcrB 265-AP) showed that the SRP requirement for efficient insertion correlated with the presence of a large periplasmic domain (P1). As previously reported, perturbation of the SRP pathway also affected the insertion of a polytopic AcrB-AP fusion. Even exhaustive SRP depletion, however, failed to block the insertion of any AcrB derivative by more than 50%. Taken together, these data suggest that many proteins that are normally targeted by SRP can utilize alternative targeting pathways and that the structure of both hydrophilic and membrane-spanning domains determines the degree to which the biogenesis of a protein is SRP dependent.
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Liu, Jiquan, Yeping Xu, Pedro B. Groszewicz, Martin Brodrecht, Claudia Fasel, Kathrin Hofmann, Xijuan Tan, Torsten Gutmann, and Gerd Buntkowsky. "Novel dirhodium coordination polymers: the impact of side chains on cyclopropanation." Catalysis Science & Technology 8, no. 20 (2018): 5190–200. http://dx.doi.org/10.1039/c8cy01493k.

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Adhikari, Pramisha, Bing Xie, Ana Semeano, Alessandro Bonifazi, Francisco O. Battiti, Amy H. Newman, Hideaki Yano, and Lei Shi. "Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor." Biomolecules 11, no. 4 (April 13, 2021): 570. http://dx.doi.org/10.3390/biom11040570.

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The dopamine D2/D3 receptor (D2R/D3R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D3R over D2R is attractive because of D3R’s restricted tissue distribution with potentially fewer side-effects and its putative neuroprotective effect. However, the high sequence homology between the D2R and D3R poses a challenge in the development of D3R selective agonists. To address the ligand selectivity, bitopic ligands were designed and synthesized previously based on a potent D3R-preferential agonist PF592,379 as the primary pharmacophore (PP). This PP was attached to various secondary pharmacophores (SPs) using chemically different linkers. Here, we characterize some of these novel bitopic ligands at both D3R and D2R using BRET-based functional assays. The bitopic ligands showed varying differences in potencies and efficacies. In addition, the chirality of the PP was key to conferring improved D3R potency, selectivity, and G protein signaling bias. In particular, compound AB04-88 exhibited significant D3R over D2R selectivity, and G protein bias at D3R. This bias was consistently observed at various time-points ranging from 8 to 46 min. Together, the structure-activity relationships derived from these functional studies reveal unique pharmacology at D3R and support further evaluation of functionally biased D3R agonists for their therapeutic potential.
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Potapov, Andrei S., Evgenia A. Nudnova, Vladimir D. Ogorodnikov, Tatiana V. Petrenko, and Andrei I. Khlebnikov. "Synthesis of New Bitopic Tetra(pyrazolyl)-Ligands with Neopentane and O-Xylene Backbones." Scientific World Journal 2012 (2012): 1–5. http://dx.doi.org/10.1100/2012/798271.

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Several new bitopic pyrazole-containing ligands were prepared from the corresponding pyrazoles and tetrahalogen or tetratosyloxy derivatives of o-xylene and neopentane in a superbasic medium (KOH-DMSO).
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Schrage, Ramona, and Evi Kostenis. "Functional selectivity and dualsteric/bitopic GPCR targeting." Current Opinion in Pharmacology 32 (February 2017): 85–90. http://dx.doi.org/10.1016/j.coph.2016.12.001.

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Dissertations / Theses on the topic "Bitopic"

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Kirrbach, Jan Verfasser], Dieter [Akademischer Betreuer] [Langosch, Dieter [Akademischer Betreuer] Langosch, and Isaiah [Akademischer Betreuer] Arkin. "Mapping of the Human Bitopic Membrane Proteome for Self-Interacting Transmembrane Helices / Jan Kirrbach. Gutachter: Dieter (Prof. Dr.), Arkin, Isaiah Langosch. Betreuer: Dieter Langosch." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1031582592/34.

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Matera, C. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150203.

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Background - An increasing number of receptor interactions depends on their physical association, and receptor hetero(di)mers usually show pharmacological and functional properties different from those of their constituent partners, thus behaving as new receptor entities. In particular, striatal dopaminergic transmission appears to be under the control of receptor heteromers containing D2 autoreceptors and non-alpha7 nicotinic acetylcholine receptors (nAChRs). This evidence encouraged an in-depth investigation of the biochemical and functional interactions between dopaminergic autoreceptors and nAChRs containing the beta2 subunit. Aims - The deliberate, rational design of bifunctional (multiple) ligands has gained a relevant interest in the medicinal chemistry research. These compounds may serve as suitable molecular probes to study in depth receptor architectures and, in some instances, represent innovative approaches for therapeutic intervention. The results of the present research project are directed to explore new potential pharmacological approaches to the therapy of nicotinic addiction on one hand and of Parkinson’s disease on the other. Methods - A common strategy was applied to the synthesis of two classes of designed bifunctional derivatives, that is we linked the chosen monovalent fragments with spacers of different length. Since the spacer should in principle not interfere with the ligand-receptor interactions involving the monomeric moieties, polymethylene chains were used to connect the pharmacophoric component parts. We synthesized bivalent derivatives formed by a) a D2/D3 agonist moiety and a nicotinic alpha4beta2 antagonist fragment and b) a D2/D3 antagonist moiety and a nicotinic alpha4beta2 agonist fragment. The structures of the parent ligands were selected after a critical inspection of the literature. Results - We initially prepared bivalent derivatives characterized by a D2/D3 agonist moiety and a nicotinic alpha4beta2 antagonist fragment. The structural features of the chosen selective alpha4beta2 antagonists were those of N-n-alkylnicotinium analogues (NONI and NDNI), whereas we chose 2-(aminomethyl)chromane (2-AMC) was the molecular portion endowed with the required D2/D3 receptor agonist properties. Bitopic compounds with the above cited molecular features should ideally inhibit dopamine release, a condition that could be exploited in therapeutic protocols for nicotine addiction. On the other hand, the synthesis of bivalent derivatives incorporating a D2/D3 antagonist moiety and a nicotinic alpha4beta2 agonist fragment was achieved using the D2/D3 antagonist Raclopride and the selective highly potent alpha4beta2 agonist A-84543 as building blocks. Bitopic compounds with such a molecular skeleton, able to recognize presynaptic heterodimeric receptor populations, should functionally enhance dopamine release, thus representing potential drug candidates for the treatment as Parkinson’s disease. Both classes of hybrid derivatives and their individual precursor ligands were assayed a) for their affinity and specificity at the nAChRs in striatal tissues and at the D2 receptor subtypes transfected into HEK cells, and b) for their functional activity, that is the capacity to favor or inhibit the release of [3H]dopamine (DA) from striatal slices stimulated by nicotinic agonists and/or the depolarizing agent potassium chloride. As an example, in the first group of derivatives, one of the bivalent compounds showed an interesting functional profile, since it totally inhibited the release of [3H]DA, being more potent than its parent nicotinic alpha4beta2antagonist. Conclusion - The PhD experimental activity was devoted to the design, synthesis, and structure-activity studies of two distinct groups of bifunctional ligands targeting specific nicotinic and dopaminergic receptor subtypes. The preliminary results obtained for some of the studied derivatives encourage a further deepening of their functional profile (i.e., with electrophysiological experiments) coupled with the proof of concept of a truly bivalent mode of action.
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Stenholm, Roland. "Time-Multiplexed Channel Switches for Dynamic Frequency Band Reallocation." Thesis, Linköpings universitet, Datorteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128793.

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A partially parallel reconfigurable channel switch is constructed for use in DFBR. Its permutation can be changed while running without any interruption in the streams of data. Three approaches are tried: one based on asorting network, one based on memories and multiplexers and one based on a Clos network. Variants with the pattern stored in memories and in shift registers are tried. They are implemented in automatically generated Verilog and synthesized for an FPGA. Their cost in terms of area use, memory use and maximum clock frequency is compared and the results show that the Clos based approach is superior in all aspects and that pattern data should not be saved in shift registers. The work is open source and available for download at https://github.com/channelswitch/channelswitch.
En delvis parallel och delvis seriell kanalswitch för användning inom DFBR skapas. Dess permutation kan ändras medan den kör utan avbrott i dataströmmen. Tre alternativ undersöks: ett baserat ett sorteringsnätverk, ett baserat på minnen och multiplexrar och ett som baseras på Clos-nätverk. Versioner med mönsterdata sparad i skiftregister och i minnen prövas. De implementeras i automatiskt genererad Verilog och synthesiseras för en FPGA. Deras kostnad i areaanvändning, minnesanvändning och maximal klockfrekvens jämförs. Resultaten visar i princip att Clos-nätverken är bäst i alla avseenden och att mönsterdata ska sparas i RAM-minnen och inte i skiftregister. Arbetet är open source och kan laddas ner från https://github.com/channelswitch/channelswitch.
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Li, Guan-Wei, and 李冠緯. "Self-assembly of bitopic membrane protein M2 of influenza A." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/13847684437632686457.

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碩士
國立陽明大學
生醫光電研究所
104
Ion channels are pore-forming proteins in charge of permeability of specific ions on lipid bilayer by electrochemical gradients. They exist not only in every cellular membrane but in most of viruses and reveal the key part in how cells and viruses work. To investigate how ion channel proteins interact with each other from the aspect of biophysics, there is a program built for helping the user to generate the whole energy profile. This program of ion channel assembly (PICA) has 5 degrees of freedom (DOFs), namely, D, θ r, θ t, N and h, in order to describe each of the ion channel structures. PICA screens every point of DOF in the range the user is setting. Unlike other existing docking program or software that they search space all around the target proteins for proper conformation, PICA only search the space around the side surface of trans-membrane domain (TMD) of protein to find the its possible pore structure. Thus, it is more like a 2 dimensional search method rather than 3 dimensional search algorithm like other programs for globular proteins. The situation of PICA is different from those of the others tools. PICA is built under the assumption that pore-forming proteins are assembled on lipid bilayer of endoplasmic reticulum; that also is, these pore-forming proteins don’t need to be tilted at big angles and is assembled together under the lipid environment whose dielectric constant is nearly 2. An important feature of PICA is that the displacement of the structure includes the Cα atoms and sidechain. It turns out that the Root-Mean-Square Deviation (RMSD) values of top 10 structures are large; however, all of top 10 structures form proper orientation of residues to function as channels. In this research, I also performed other docking software and programs to assemble M2 proton channel of influenza A virus. These software and programs are Molecular Operating Environment (MOE), Sam, M-ZDOCK and Rosetta. In order to see how well it is on predicting pore structures of membrane proteins, RMSD comparison of backbones between original structure and prediction is applied. I also checked the top 10 prediction structures which these software and programs provided to user. Most of these prediction results failed to reproduce the actual structure of the M2 proton channel, and even though RMSD values of some of the predictions are small enough that they seem promising. In the case of M2 proton channel, the pore structure of the M2 channel must have four His and four Trp positioned inside the pore region in order to be proton conducting. The His of channel function as a pH sensor and the Trp forms the ion gate of the channel3. Most of the prediction results of existing software and programs have presented incorrect orientation of His and Trp. The final comparison tells the users that PICA provided ten proper structures to the user, and Sam provided the two, and M-ZDOCK provided the one and both MOE and Rosetta failed to provide any proper structures on the docking of M2 proton channel of influenza A virus.
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MARTINO, MARIA VITTORIA. "Progettazione, sintesi e valutazione farmacologica preliminare di ligandi e modulatori dei recettori colinergici centrali." Doctoral thesis, 2015. http://hdl.handle.net/2158/986407.

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Il lavoro effettuato in questi 3 anni di dottorato è stato svolto nell’ambito del progetto PRIN 2009, basato sulla ricerca di sostanze in grado di modulare, direttamente o indirettamente, i recettori colinergici a livello centrale; lo scopo è quello di sviluppare molecole in grado di migliorare i processi cognitivi, quindi utilizzabili nel trattamento di patologie caratterizzate da deficit cognitivo come morbo Alzheimer, schizofrenia, mild cognitive impairment. Le linee di ricerca su cui si è sviluppato tale progetto andavano in 3 direzioni: - Ricerca di ligandi muscarinici selettivi; - Ricerca di sostanze dotate di attività nootropa formalmente correlate al Piracetam. -Ricerca di ligandi nicotinici; Le prime due sono oggetto della mia tesi di dottorato; i due diversi ambiti verranno descritti separatamente.
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XIE, ZHENG-ZHONG, and 謝正忠. "Fault diagnosis of bitonic sorters." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/09408158729234113650.

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"Algebraic study of generalization and redundancy of the bitonic sorter." 2003. http://library.cuhk.edu.hk/record=b5891445.

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Qian Zhengfeng.
Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.
Includes bibliographical references (leaves 127-129).
Abstracts in English and Chinese.
Chapter Chapter 1 --- Groundwork --- p.1
Chapter 1.1 --- Introduction --- p.1
Chapter 1.2 --- Exchange Patterns --- p.5
Chapter 1.3 --- Multistage Networks --- p.9
Chapter 1.3.1 --- Multistage Networks --- p.9
Chapter 1.3.2 --- Banyan-type Networks --- p.11
Chapter 1.4 --- Networks of Sorting Cells --- p.15
Chapter 1.5 --- Symbolic Representation and Matrix Representation --- p.19
Chapter 1.5.1 --- Symbolic Representation of a Multistage Interconnection Network --- p.19
Chapter 1.5.2 --- Symbolic Representation of a Network of Sorting Cells --- p.21
Chapter 1.5.3 --- Matrix Representation of a Network of Sorting Cells --- p.22
Chapter 1.6 --- Summary --- p.24
Chapter Chapter 2 --- Construction of Generalized Bitonic Sorters by Merging Rotated Monotonic Sequences --- p.25
Chapter 2.1 --- Merging Networks --- p.25
Chapter 2.1.1 --- Recursive 2-stage Construction --- p.26
Chapter 2.1.2 --- UC/CU Non-blocking Switches --- p.35
Chapter 2.1.3 --- Circular Sorters and Merging Networks --- p.41
Chapter 2.2 --- Construction of Generalized Bitonic Sorters --- p.48
Chapter 2.2.1 --- Bitonic Ar-sorters and Bitonic Dr-sorters --- p.48
Chapter 2.2.2 --- Algorithms for Construction of Generalized Bitonic Sorters by Merging Rotated Monotonic Sequences --- p.51
Chapter 2.3 --- Summary --- p.73
Chapter Chapter 3 --- Construction of Generalized Bitonic Sorters by Cross-k Cell Rearrangement --- p.74
Chapter 3.1 --- Cross-k Cell Rearrangement on a Multistage Network --- p.74
Chapter 3.1.1 --- Intra-stage Cell Rearrangement --- p.74
Chapter 3.1.2 --- Equivalence of Networks --- p.77
Chapter 3.1.3 --- Cross-k Cell Rearrangement --- p.80
Chapter 3.2 --- Construction of Generalized Bitonic Sorters --- p.85
Chapter 3.3 --- Summary --- p.99
Chapter Chapter 4 --- Redundancy of the Bitonic Network --- p.100
Chapter 4.1 --- Counting of Identified Generalized Bitonic Sorters --- p.100
Chapter 4.2 --- Redundancy of the Bitonic Network --- p.110
Epilogue --- p.112
Appendix C Program for Exhaustive Search of 8×8 Generalized Bitonic Sorters --- p.113
References --- p.127
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Zhou, Jun Jie, and 周俊杰. "Fault diagnosis and tolerance of banyan networks and bitonic sorters." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/79589418381336385292.

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LIN, QUN-XIANG, and 林群翔. "On bitonic sorting network for an arbitrary number of keys." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/66621094291821020727.

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Books on the topic "Bitopic"

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Bitopia. Boston, Massachusetts: Olivander Press, 2012.

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Kitevski, Marko. Bitovi prikazni i anegdoti. Skopje: Kameleon, 2010.

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Mandzhukov, P. G. Skopska Crna Gora: Bitovi beleški. Skopje: Knigoizdatelstvo Mi-An, 2011.

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Sgurev, Vasil. 32-bitovi mikrokompi͡u︡tŭrni rabotni stant͡s︡ii za avtomatizat͡s︡ii͡a︡ na proektiraneto. Sofii͡a︡: Izd-vo na Bŭlgarskata akademii͡a︡ na naukite, 1989.

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R, Kraleva, Nauchen t͡s︡entŭr po vŭtreshna tŭrgovii͡a︡, uslugite i mestnata promishlenost (Sofia, Bulgaria), and Otraslov t͡s︡entŭr za nauchna i tekhnicheska informat͡s︡ii͡a︡ (Sofia, Bulgaria), eds. Sistema za izuchavane tŭrseneto na bitovi uslugi: Tekhniko-ikonomicheski pokazateli. Sofii͡a︡: [s.n.], 1985.

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Minko, Minkov, Marinov St, Totev Ĭordan, and Programno-t͡s︡elevi kolektiv po edinna sistema za sot͡s︡ialno-demografska statistika (Bulgaria), eds. Kulturno-bitovi uslovii͡a︡ na zhivot na naselenieto v NR Bŭlgarii͡a︡. Sofii͡a︡: T͡S︡entralno statistichesko upravlenie, 1990.

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Kiril, Aleksiev, Ivanov Stefan inzh, Vasileva Marii͡a︡ inzh, and Bulgaria. Komitet po teritorialno i selishtno ustroĭstvo., eds. Kont͡s︡ept͡s︡ii͡a︡ za obezvrezhdane i opolzotvori͡a︡vane na tvŭrdite bitovi otpadŭt͡s︡i v NRB do 2010 godina. Sofii͡a︡: Kom-t po teritorialno i selishtno ustroĭstvo pri Ministerskii͡a︡ sŭvet, 1989.

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Il, Kopralev, and T͡S︡entur za nauchno-izsledovatelska i inzhenerno-vnedritelska deĭnost "Koopprogres.", eds. Prognoza za razvitie na kooperativnite bitovi uslugi v N R B do 2,000 godina. Sofii͡a︡: T͡S︡entr. kooperativen sŭi͡u︡z, T͡S︡entŭr za nauchno-izsledovatelska i inzhenerno-vnedritelska deĭnost "Koopprogres", 1986.

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Daskalova-Zheli͡azkova, Nevena. Karioti: Etnicheska prinadlezhnost i kulturno-bitovi cherti v krai͡a na XIX i nachaloto na XX vek. Sofii͡a: Izd-vo na Bŭlgarskata akademii͡a na naukite, 1989.

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Bulgaria. Komitet po teritorialno i selishtno ustroĭstvo. Sbornik ot normativni dokumenti v oblastta na tretiraneto na tvŭrdite bitovi otpadŭt͡s︡i (TBO) i pochistvaneto na naselenite mesta. Sofii͡a︡: Ministerski sŭvet, Komitet po teritorialno i selishtno ustroĭstvo, 1989.

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Book chapters on the topic "Bitopic"

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Raab, Wolfgang. "Bitoric." In Encyclopedia of Ophthalmology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-35951-4_695-1.

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Raab, Wolfgang. "Bitoric." In Encyclopedia of Ophthalmology, 262. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-540-69000-9_695.

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Weik, Martin H. "bitoric lens." In Computer Science and Communications Dictionary, 126. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_1615.

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Kielmann, Thilo, Sergei Gorlatch, Utpal Banerjee, Rocco De Nicola, Jack Dongarra, Piotr Luszczek, Paul Feautrier, et al. "Bitonic Sort." In Encyclopedia of Parallel Computing, 139–46. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-09766-4_124.

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Kielmann, Thilo, Sergei Gorlatch, Utpal Banerjee, Rocco De Nicola, Jack Dongarra, Piotr Luszczek, Paul Feautrier, et al. "Bitonic Sorting, Adaptive." In Encyclopedia of Parallel Computing, 146–57. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-09766-4_101.

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Kielmann, Thilo, Sergei Gorlatch, Utpal Banerjee, Rocco De Nicola, Jack Dongarra, Piotr Luszczek, Paul Feautrier, et al. "Bitonic Sorting Network." In Encyclopedia of Parallel Computing, 146. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-09766-4_2217.

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Mankowski, Michal, and Mikhail Moshkov. "Optimal Bitonic Tour." In Dynamic Programming Multi-Objective Combinatorial Optimization, 135–45. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63920-4_12.

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Bove, Ana, and Thierry Coquand. "Formalising Bitonic Sort in Type Theory." In Lecture Notes in Computer Science, 82–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11617990_6.

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Gronemann, Martin. "Bitonic st-orderings for Upward Planar Graphs." In Lecture Notes in Computer Science, 222–35. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-50106-2_18.

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Gronemann, Martin. "Bitonic st-orderings of Biconnected Planar Graphs." In Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications, 162–73. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-662-45803-7_14.

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Conference papers on the topic "Bitopic"

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Potapov, Andrei, Andrei Khlebnikov, and Evgenia Nidnova. "Synthesis of new bitopic tetra(pyrazolyl)-ligands with neopentane and o-xylene backbones." In The 15th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00739.

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Prabhu, Varun Vijay, Sara Morrow, Caroline A. Cuoco, Abed R. Kawakibi, Jinkyu Jung, Neel Madhukar, Matthew J. Garnett, et al. "Abstract 5688: IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5688.

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Liszka, Kathy J., and Kenneth E. Batcher. "A Generalized Bitonic Sorting Network." In 1993 International Conference on Parallel Processing - ICPP'93 Vol1. IEEE, 1993. http://dx.doi.org/10.1109/icpp.1993.23.

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Lee, De-lei, and Kenneth Batcher. "On Sorting Multiple Bitonic Sequences." In 1994 International Conference on Parallel Processing (ICPP'94). IEEE, 1994. http://dx.doi.org/10.1109/icpp.1994.137.

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Angermeier, J., E. Sibirko, R. Wanka, and J. Teich. "Bitonic Sorting on Dynamically Reconfigurable Architectures." In Distributed Processing, Workshops and Phd Forum (IPDPSW). IEEE, 2011. http://dx.doi.org/10.1109/ipdps.2011.164.

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dos Santos, Lucca, Edson Tavares de Camargo, and Elias P. Duarte Jr. "Uma Implementação MPI Tolerante a Falhas do Algoritmo Bitonic Sort." In XX Workshop de Testes e Tolerância a Falhas. Sociedade Brasileira de Computação - SBC, 2019. http://dx.doi.org/10.5753/wtf.2019.7714.

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Abstract:
O Bitonic Sort executa a ordenação através de operações de divisão e mesclagem de sequências bitônicas. Uma sequência é dita bitônica se seus elementos crescem e decrescem a partir de algum ponto. Apesar de muitas variantes do algoritmo encontradas na literatura, não se conhece uma implementação paralela capaz de tolerar falhas de processos em tempo de execução. Este trabalho apresenta uma implementação MPI do Bitonic Sort capaz de suportar até n-1 falhas de processos, onde n é o total de processos. A mais recente especificação de tolerância a falhas proposta pelo MP-Fórum é empregada no desenvolvimento da solução. Resultados experimentais mostram a eficiência da implementação na ordenação de até 1 bilhão de números inteiros.
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Panda, Anukul Chandra, Pankaj K. Sa, and Banshidhar Majhi. "Bitonic sort in shared SIMD array processor." In the 2011 International Conference. New York, New York, USA: ACM Press, 2011. http://dx.doi.org/10.1145/1947940.1947998.

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Even, Shimon, S. Muthukrishnan, Michael S. Paterson, and Süleyman Cenk Sahinalp. "Layout of the batcher bitonic sorter (extended abstract)." In the tenth annual ACM symposium. New York, New York, USA: ACM Press, 1998. http://dx.doi.org/10.1145/277651.277683.

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Couturier, Raphaël. "Formal engineering of the bitonic sort using PVS." In 2nd Irish Workshop on Formal Methods. BCS Learning & Development, 1998. http://dx.doi.org/10.14236/ewic/fm1998.2.

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Li, Jian. "An Improved Dynamic Programming Algorithm for Bitonic TSP." In 2nd International Symposium on Computer, Communication, Control and Automation. Paris, France: Atlantis Press, 2013. http://dx.doi.org/10.2991/isccca.2013.7.

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