Academic literature on the topic 'Biosafety'

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Journal articles on the topic "Biosafety"

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Truchaud, A., P. Schnipelsky, H. L. Pardue, J. Place, and K. Ozawa. "Increasing the biosafety of analytical systems in the clinical laboratory." Journal of Automatic Chemistry 16, no. 2 (1994): 67–70. http://dx.doi.org/10.1155/s1463924694000076.

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Biosafety is an important part of the know-how of all clinical laboratory professionals. Biosafely must have high priority in the design and use of analytical systems. Attention should be focused on reducing the handling of biological specimens, reducing biohazards to laboratory personnel, and on improving the labelling and containment of biohazardous materials. In this paper, biosafety issues are discussed in relation to the design of analytical systems, their use and maintenance.
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Voss, Andreas, Sigfrido Rangel-Frausto, and Jan Kluytmans. "Biosafety." Infection Control & Hospital Epidemiology 20, no. 9 (September 1999): 644. http://dx.doi.org/10.1017/s0195941700071253.

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Yu, Yingjie, Jianxun Ding, Yunhao Zhou, Haihua Xiao, and Guizhen Wu. "Biosafety chemistry and biosafety materials: A new perspective to solve biosafety problems." Biosafety and Health 4, no. 1 (February 2022): 15–22. http://dx.doi.org/10.1016/j.bsheal.2022.01.001.

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Galyukova, M. I. "Biosafety Architectonics." Lex Russica 75, no. 10 (October 18, 2022): 54–67. http://dx.doi.org/10.17803/1729-5920.2022.191.10.054-067.

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The paper examines the issues of biosafety as an independent direction of national security. The development of biotechnologies inevitably leads to the emergence of new threats to society and the state, requires a comprehensive study of the current legislation in the field of security. The paper elucidates scientific approaches to the definition of biosafety in a narrow and broad senses. The author notes that the appearance of the official definition of biosafety is a significant step in the development of the system of interdepartmental interaction and an independent direction of national security, but by no means a revolutionary novation. In addition, the paper provides a semantic and meaningful analysis of the concepts of biorisk, biohazard, biological factor, determines the relationship of biological threats and biotechnologies. The paper defines a new independent component of biological safety, namely, genetic safety. The author notes the positive dynamics of biosafety development as one of the directions of national policy and at the same time states obvious legislative and methodological gaps. First, a biohazard is the result of the transformation of a biorisk into a concrete factual circumstance that creates a real danger to human life and health, as well as the security of society, the state and humanity. Second, there is no concept of biotechnologies, their types and classification through the prism of biosafety. Third, genetic safety is an independent component of biological safety. The concept of «genetic safety» should be developed. Fourth, biosafety is an independent vector of the national policy of the state aimed at the effective prevention of biological threats, as well as the development of biotechnologies without risk to human life and health by creating a high-quality legislative framework, an adequate level of law enforcement, the formation of legal awareness and legal culture of the population.
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Desrosiers, R., and E. Hunter. "AIDS biosafety." Science 252, no. 5010 (May 31, 1991): 1231. http://dx.doi.org/10.1126/science.1953906.

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Byers, Karen. "Biosafety Tips." Applied Biosafety 7, no. 2 (June 2002): 94–95. http://dx.doi.org/10.1177/153567600200700209.

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Byers, Karen B. "Biosafety Tips." Applied Biosafety 7, no. 3 (September 2002): 164–66. http://dx.doi.org/10.1177/153567600200700311.

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Byers, Karen B. "Biosafety Tips." Applied Biosafety 7, no. 4 (December 2002): 250–53. http://dx.doi.org/10.1177/153567600200700408.

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Byers, Karen B. "Biosafety Tips." Applied Biosafety 8, no. 1 (March 2003): 27–29. http://dx.doi.org/10.1177/153567600300800108.

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Byers, Karen B. "Biosafety Tips." Applied Biosafety 8, no. 2 (June 2003): 81–84. http://dx.doi.org/10.1177/153567600300800207.

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Dissertations / Theses on the topic "Biosafety"

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Margaritis, D. "Biosafety and biosecurity : design, construction and facility management." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1551533/.

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High containment laboratories play an important role in modern society allowing for the research and diagnosis of high-risk pathogens and infectious diseases whilst ensuring protection from unintentional harm to the local community as a result of escaped pathogens. This thesis focuses on the third function, investigating pressure integrity testing. A thorough literature review of biocontainment has been conducted to present the scientific knowledge in the area and identify knowledge gaps. The theoretical background of the current integrity tests was derived, and using the resulting mathematical formulas, a comparison of the theoretical prediction of common pressure integrity tests was conducted. Furthermore, real pressure integrity testing data from a state of the art Biosafety Level 4 (BSL-4) laboratory was analysed. The literature review and the numerical analysis identified key limitations of the current tests, showing the need for a new testing methodology. This study contributes to science by introducing a new pressure integrity testing methodology for high containment laboratories taking into consideration biocontainment and fumigation requirements. Furthermore, the most common leakage points in containment laboratories have been identified though a thorough in-situ investigation conducted at the commissioning stage of one of the largest biomedical facilities in the world. This study suggests that gross leaks are due to a failure in construction details and identifies the importance of quality assurance at the construction stage. Also, case studies based on the work conducted with Laing O'Rourke (the Industrial Sponsor of this EngD) are presented demonstrating the industrial application of this Doctorate in pressure integrity testing of high containment laboratories. It is expected by the Author that this research will have an impact on the industry as it can contribute to the establishment of a regulation controlling the airtightness levels of high containment laboratories, which could be implemented by the Health and Safety Executive (HSE) to ensure that high containment laboratories in the UK provide safe environments for the study of high-risk agents and infectious diseases.
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Loosen, Katja. "Das Biosafety-Protokoll von Cartagena zwischen Umweltvölkerrecht und Welthandelsrecht." Berlin Logos-Verl, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2748303&prov=M&dok_var=1&dok_ext=htm.

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Loosen, Katja. "Das Biosafety-Protokoll von Cartagena zwischen Umweltvölkerrecht und Welthandelsrecht /." Berlin : Logos Verlag, 2006. http://www.gbv.de/dms/spk/sbb/recht/toc/505260972.pdf.

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Du, Plessis Marthinus Johannes. "The international political economy of the Cartagena Protocol on biosafety." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52543.

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Thesis (MA)--University of Stellenbosch, 2001.
ENGLISH ABSTRACT: The development of the global biotechnology industry largely coincided with the development of the US biotechnology industry. This resulted in this industry's oligopolistic and centralised nature where only a few multinational chemical and pharmaceutical companies control most biotechnology processes and production of commodities emanating from these processes. The governance of biotechnology has, until recently, been dominated by state actors who have endeavoured to secure national interests, including those of large multinational corporations (MNCs) based within their boundaries. The technological ability of developed states to exploit and use unevenly distributed resources to their advantage means that an uneven relationship exists between these and poor developing countries. This has been highlighted by differences in public opinion about the role and application of biotechnology in society. While some opinions favour the use and application of biotechnology to enhance food supplies and boost production levels and trade, other opinions caution against the possible hazards that genetically manipulated organisms (GMOs) hold for the environment and human existence. The commercialisation of biotechnology has resulted in the exponential growth of genetically manipulated crops in especially the United States and countries like Argentina and Canada. These countries produce large surpluses of staple grains such as corn and soya and try to sell these to countries with food supply problems. The clash in commercial interests stemming from developed countries' insistence on the protection of intellectual property rights (IPR) on genetically manipulated (GM) seeds has caused considerable conflict with poor farmers who will not be able to sustain their livelihoods if they cannot save seeds for future harvests. This is one aspect of the problems surrounding the protection of knowledge products that is exacerbated by the scientific uncertainty pertaining to the risk involved with biotechnology. While some observers agitate for precaution with the use of GMOs, others feel that a lack of scientific proof of harm is sufficient grounds for proceeding with developments in biotechnology. Conversely, there are some that feel that biotechnology is market driven instead of human needs driven, ultimately resulting in developing countries receiving very little benefit from it. The Cartagena Protocol on biosafety was drafted to address some of the difficulties involved with the transboundary movement of GMOs. Although it holds very specific advantages for developing countries, as a regulatory framework it is limited in its scope and application. Developing countries are limited in their policy options to address their need to protect biodiversity and secure their food supply. This means that considerable challenges and constraints await these countries in utilising global governance of public goods and building their human and technological capacities.
AFRIKAANSE OPSOMMING: Die ontwikkeling van die globale biotegnologie-industrie het grootliks saamgeval met die ontwikkeling van die Verenigde State se biotegnologie-industrie. Dit het aanleiding gegee tot hierdie industrie se oligopolistiese en gesentraliseerde aard waar slegs enkele multinasionale chemiese en farmaseutiese maatskappye die meeste biotegnologie prosesse en die vervaardiging van kommoditeite uit daardie prosesse beheer. Die regering van biotegnologie was tot onlangs oorheers deur staatsakteurs wie gepoog het om nasionale belange te beskerm, insluitend die belange van multinasionale korporasies (MNK) wat vanuit hulle grondgebied funksioneer. Die tegnologiese vermoë van ontwikkelde state om oneweredig verspreide hulpbronne tot eie gewin te benut beteken dat 'n ongelyke verhouding bestaan tussen hierdie en arm ontwikkelende state. Dit word beklemtoon deur verskille in openbare mening oor die rol en aanwending van biotegnologie in die samelewing. Terwyl sekere opinies ten gunste van die aanwending van biotegnologie vir die verbetering van voedselbronne en produksievlakke en handel is, dui ander opinies op die moontlike gevare wat geneties gemanipuleerde organismes (GMOs) vir die omgewing en menslike voortbestaan inhou. Die kommersialisering van biotegnologie het gelei tot die eksponensiële groei van geneties gemanipuleerde gewasse in veral die Verenigde State en state soos Argentinië en Kanada. Hierdie state produseer groot hoeveelhede stapelgrane soos mielies en soja en poog om dit te verkoop aan state met voedselvoorsieningsprobleme. Die botsing in kommersiële belange wat spruit uit ontwikkelde state se aandrang op die beskerming van intellektuele eiendomsreg op geneties gemanipuleerde saad veroorsaak beduidende konflik met arm landbouers wie nie hulle lewensonderhoud kan verseker as hulle nie saad kan berg vir toekomstige saaiseisoene nie. Dit is een aspek van die problematiek rondom die beskerming van kennisprodukte wat vererger word deur die wetenskaplike onsekerheid wat gepaard gaan met die risiko's van biotegnologie. Terwyl sekere waarnemers vir waaksaamheid pleit in die gebruik van GMOs, is daar ander wat voel dat 'n gebrek aan wetenskaplike bewyse van skade genoegsame gronde is vir die voortsetting van ontwikkelings in biotegnologie. Insgelyks is daar diegene wat meen dat biotegnologie markgedrewe in plaas van menslike behoefte gedrewe is, wat uiteindelik daartoe lei dat ontwikkelende state baie min voordeel daaruit trek. Die Kartagena Protokoloor bioveiligheid is opgestel om van die probleme betrokke by die oorgrens verskuiwing van GMOs aan te spreek. Hoewel dit spesifieke voordele vir ontikkelende state inhou is dit as reguleringsraamwerk beperk in omvang en aanwending. Ontwikkelende state het beperkte beleidsopsies om hulle behoefte om biodiversiteit te beskerm en voedselvoorsiening te verseker, aan te spreek. Dit beteken dat beduidende uitdagings en beperkings hierdie state in die benutting van globale regering van openbare goedere vir die bou van menslike en tegnologiese kapasiteite in die gesig staar.
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Agutter, Paula Anne. "Computational fluid dynamics as a tool for quantitative biosafety studies." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286672.

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モニカ, ラコヴィタ, and Monica Racovita. "Policies of genetically modified crops in India: food security and biosafety politics." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12252585/?lang=0, 2011. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12252585/?lang=0.

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Joy, Faida. "Biosafety Regulation: a comparative analysis of the South African and Ugandan experience." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/4478.

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This study provides a critical and comparative analysis of biosafety regulation in South Africa and Uganda. The overall objective of the study is to establish which country prescribes a more adequate regulatory regime. Biosafety regulation under international and regional law is the first key aspect that this paper examines. This is done in order to set out a context under which domestic biosafety regulation is examined. This study argues that international law generally sets minimum standards while regional law sets higher standards for biosafety regulation. The second key area examined is biosafety regulation in South Africa. The paper sets out an overview of the relevant biosafety laws in South Africa and conducts a critical analysis of these laws pointing out their strengths and weaknesses. The study is premised on the argument that South African regulatory regime is inadequate for purposes of regulating biosafety. The third part of this paper focuses on Uganda's regulatory regime. A similar analysis was carried where the study found that the Ugandan regime is reasonably adequate for purposes of protection of the environment and human health. The final key aspect of this paper is a comparative analysis of biosafety regulation in South Africa and Uganda. This is done thematically, setting out differences and similarities. This part examines the extent to which South Africa and Uganda have attempted to comply with their international obligations. This paper concludes that, although the Ugandan regulatory regime (both existing and proposed) has some weaknesses, it is a more adequate regime than the South African one. Further, Uganda is more compliant with the biosafety Protocol and the African Model Law than South Africa.
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Kingiri, Ann Njoki. "An enquiry into biosafety regulations implementation in Kenya : perspectives and roles of scientists." Thesis, Open University, 2009. http://oro.open.ac.uk/54654/.

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This thesis explores the perspectives and related behavioural shifts of the heterogeneous Kenyan scientific community in the development and subsequent implementation of biosafety regulations. Kenya's biotechnology innovation system has been driven largely by the contradictory framing of biotechnology as a scientific tool for innovation and international competitiveness on the one hand, and as a technology that has adverse effects on the environment on the other. A transition towards an integrated regulatory system over the last one and half decades had entailed unprecedented institutional configurations and changes in behavioural patterns of the scientific community. To analyse the role of the scientific community in shaping the regulatory process and instruments in the evolving biotechnology innovation system, the thesis draws on interviews, documentary analysis and observation data collected from a wide range of scientist and non scientist actors. It finds that, as scientists adapt to institutional changes necessitated by the biotechnology innovation transition, they have been reconstituting themselves consciously and unconsciously around different linear and non linear modes of knowledge production. In the process, learning has occurred, knowledge has been produced and diffused impacting on both technological innovation and emergence of a regulatory regime. The latter is however bounded up in the former. The thesis further finds that the capacity to influence the regulatory process and instruments was spurred not only by the individualised scientific expertise, but also by the relationships and coalitions built around the different regulatory phases. Knowledge produced in this regulatory context challenges the application of knowledge theories in the light of its potential to influence scientific practice and regulatory policy instruments. From lessons and insights drawn from theories of knowledge, the emerging policies and practices are skewed towards a narrow, linear form of technical and scientific expertise, thus ignoring many underpinning factors that are important for emergence of socially desirable processes and policies. The study recommends reconceptualisation of both scientific practice and policymaking in reflexive and systemic ways that encourage incremental learning.
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Cuevas, Edmund B. "Biosecurity and biosafety systems in the Philippines and New Zealand : A cross-case analysis." Thesis, University of Canterbury. Forestry, 2005. http://hdl.handle.net/10092/6883.

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There is a growing importance for both biosecurity and biosafety globally and locally. In this context, this study examined and compared the biosecurity and biosafety systems of the Philippines and New Zealand. This study also considered the central issue of whether the international idea that biosecurity should be the strategic and integrated approach covering and encompassing biosafety and other related instruments, is present or being practised in the national context. This study utilised a qualitative research framework. It followed a case study approach as a process and a product of analysis, and employed triangulation technique of in-depth interviews, observation and used of pertinent/documents in gathering the relevant data and information. This study found that there are complexity of systems, policies, legislation, regulations, and cross-cutting issues that surround biosecurity and biosafety in the Philippines and New Zealand. In terms of biosecurity encompassing biosafety in the local context, this study revealed that such a concept is not yet present in the Philippines, whilst, to some extent it is happening in New Zealand. This study concluded that unless steps are taken to make national policies better informed, enhance understanding of the nature and relevance of biosecurity, and set strategic and operational priorities, then there will be a continuing overlap between biosecurity and biosafety at the national or local level.
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Wint, Sandra Marie Elizabeth. "Requirements for national capacity building under the framework of the Cartagena Protocol on Biosafety." Thesis, University of Sussex, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413315.

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Books on the topic "Biosafety"

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Egziabher, Tewolde Berhan Gebre. Biosafety & biodiversity. Addis Ababa: Environmental Protection Authority, 2010.

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Heinsohn, Patricia A., Robert R. Jacobs, and Beth A. Concoby, eds. Biosafety Reference Manual. 2700 Prosperity Ave., Suite 250 Fairfax, VA 22031: American Industrial Hygiene Association, 1995. http://dx.doi.org/10.3320/978-0-932627-65-0.

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Brandenberg, Oliver. Biosafety resource book. Rome: Food and Agriculture Organization of the United Nations, 2011.

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Y, Richmond Jonathan, and American Biological Safety Association, eds. Anthology of biosafety. Mundelein, IL: American Biological Safety Association, 1999.

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1940-, Kennedy M. E., and Laboratory Centre for Disease Control (Canada), eds. Laboratory biosafety guidelines. 2nd ed. Ottawa: Laboratory Centre for Disease Control, Health Canada, 1996.

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Laboratory Centre for Disease Control (Canada), Canada. Dept. of National Health and Welfare., and Medical Research Council (Canada), eds. Laboratory biosafety guidelines. Ottawa, Ont: Dept. of National Health and Welfare, 1990.

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Biosafety Act, 2002. Zomba, Malawi: Govt. Printer, 2003.

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Elizabeth, Hodson de Jaramillo, Sensi Alessandra, and Food and Agriculture Organization of the United Nations, eds. Biosafety resource book. Rome: Food and Agriculture Organization of the United Nations, 2011.

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Hambleton, P., J. Melling, and T. T. Salusbury, eds. Biosafety in Industrial Biotechnology. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1352-6.

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Schmidt, Erwin R., and Thomas Hankeln, eds. Transgenic Organisms and Biosafety. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61460-6.

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Book chapters on the topic "Biosafety"

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Falkner, Robert. "Biosafety." In Essential Concepts of Global Environmental Governance, 24. Second edition. | Abingdon, Oxon; New York: Routledge, 2021.: Routledge, 2020. http://dx.doi.org/10.4324/9780367816681-10.

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Gupta, Aarti. "Biotechnology and Biosafety." In The Handbook of Global Climate and Environment Policy, 89–106. Oxford, UK: John Wiley & Sons Ltd, 2013. http://dx.doi.org/10.1002/9781118326213.ch6.

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Gupta, Varsha, Manjistha Sengupta, Jaya Prakash, and Baishnab Charan Tripathy. "Biosafety and Bioethics." In Basic and Applied Aspects of Biotechnology, 503–20. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0875-7_24.

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Kavanagh, Vanessa, and Linda Hall. "Biology and Biosafety." In Triticale, 3–13. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22551-7_1.

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Mertsching, Jürgen. "Biosafety und Biosecurity." In Handbuch für mikrobiologische Laboratorien der Schutz- und Sicherheitsstufen 1–4, 1–31. Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-34105-3_1.

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Fleming, Diane O. "Prudent Biosafety Practices." In Biological Safety, 361–71. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815899.ch19.

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ten Have, Henk, and Maria do Céu Patrão Neves. "Safety (See Biosafety)." In Dictionary of Global Bioethics, 939. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54161-3_463.

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ten Have, Henk, and Maria do Céu Patrão Neves. "Biosafety (See Biosecurity)." In Dictionary of Global Bioethics, 199. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-54161-3_96.

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Sinha, Archana, and Pramod Kumar Pandey. "Biosafety and Hygiene." In Breeding and Culture of Freshwater Ornamental Fish, 195–208. London: CRC Press, 2023. http://dx.doi.org/10.1201/9781003456858-12.

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Ludlow, Karinne, Stuart J. Smyth, and José Falck-Zepeda. "Ensuring Functional Biosafety Systems." In Socio-Economic Considerations in Biotechnology Regulation, 277–93. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9440-9_19.

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Conference papers on the topic "Biosafety"

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BAKANIDZE, LELA, PAATA IMNADZE, SHOTA TSANAVA, and NIKOLOZ TSERTSVADZE. "NEW GEORGIAN LEGISLATION ON BIOSAFETY." In The 32nd Session of International Seminars and International Collaboration. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812701787_0025.

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Kassirov, I. S., and A. S. Dolgova. "DEVELOPMENT OF EXPRESSION CASSETTE FOR EFFICIENT PRODUCTION OF NS1 PROTEIN OF THE DENGE VIRUS." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-209.

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Nagornykh, A. M., A. I. Tyumentsev, M. A. Tyumentseva, and V. G. Akimkin. "ANALYSIS OF PROMISING OPPORTUNITIES FOR THE USE OF GENOME EDITING TECHNOLOGIES IN CATTLE AND PIG INDUSTRY IN TERMS OF SURVIVAL OF YOUNG ANIMALS IN THE NEONATAL PERIOD." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-104.

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Throughout his history, man has selected animals that have the most useful features by carrying out their intraspecific crossing leading to the fixation of these features. Survival in the neonatal period has always remained one of the most important factors in breeding animals, and with the advent of genome editing, through which mutations, often negative for health, appear in the genome, the high survival rate of genetically edited animals becomes a paramount issue.
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Belyaeva, V. V., N. V. Kozyrina, U. А. Kuimova, М. D. Goliusova, and А. N. Narkevich. "BEHAVIOURAL PATTERNS FOR PROPHYLAXIS OF COVID-19: SURVEY OF MEDICAL PROFESSIONALS AND AIDS PATIENTS." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-125.

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Terekhova, M. I., E. V. Rogacheva, I. A. Derevyanchenko, and L. A. Kraeva. "WHOLE-GENOME SEQUENCING-BASED ANTIBIOTIC RESISTANCE PROFILE OF LISTERIA MONOCYTOGENES STRAINS FROM SAINT-PETERSBURG AND THE VOLOGDA REGION." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-109.

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The increasing number of antibiotic-resistant isolates of L. monocytogenes is required to establish a genotypic resistance profile to ensure appropriate antibiotic therapy of listeriosis. In this study, whole-genome sequencing and de novo assembly was performed on L. monocytogenes strains from St. Petersburg and the Vologda region. We obtained the MLST ST, phylogenetic lineage and PCR-serogroups in silico for isolates under the study, revealed genes and mutations associated with antibiotic resistance. In general, the genetic composition was similar between the strains from different regions and included a wide range of antibiotic resistance mechanisms. Listeria strains possessed genes that code for resistance to β-lactam antibiotics, fluoroquinolones, tetracyclines and macrolides, — classes that are commonly used in the treatment of listeria infection. The present study is important in the sanitary and epidemiological surveillance of listeriosis in Russia.
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Tyumentsev, A. I., M. A. Tyumentseva, and V. G. Akimkin. "DEVELOPMENT OF APPROACHES FOR ENDOTOXIN REMOVAL FROM PROTEIN PREPARATIONS ON THE EXAMPLE OF NUCLEASES OF THE CRISPR/CAS SYSTEM." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-113.

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Removal of bacterial endotoxins from solutions of recombinant proteins is one of the most important issues in the preparation of highly purified preparations suitable for in vivo use. An optimal technology for obtaining preparations purified from bacterial endotoxins has been proposed using purification of preparations of recombinant nucleases of the CRISPR/CAS system as an example. Efficacy of developed technology was compared with other available methods. Removal of bacterial endotoxins was carried out using Triton X-114 detergent added to a concentration of 1% to a solution containing the recombinant protein. It was shown that the content of bacterial endotoxins in solutions of purified proteins obtained according to the proposed technology is 0.3–1.5 EU/ml.
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Tyumentseva, M. A., A. I. Tyumentsev, and V. G. Akimkin. "DEVELOPMENT OF APPROACHES FOR DETECTION OF GENOME-INTEGRATED PROVIRAL DNA OF THE HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) IN ULTRA LOW CONCENTRATIONS USING THE CRISPR/CAS SYSTEM." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-118.

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For the effective functioning of supervisory and health monitoring services, it is necessary to introduce modern molecular technologies into their practice. Therefore, the task of developing new effective methods for detecting pathogen, for example HIV, based on CRISPR/CAS genome editing systems, remains urgent. In the present work, guide RNAs and specific oligonucleotides were developed for preliminary amplification of highly conserved regions of the HIV-1 genome. The developed guide RNAs make it possible to detect single copies of HIV-1 proviral DNA in vitro as part of CRISPR/CAS ribonucleoprotein complexes in biological samples after preliminary amplification.
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Faizuloev, E. B., A. N. Kaira, T. R. Uzbekov, A. A. Poromov, E. A. Volynskaya, O. A. Svitich, and V. V. Zverev. "GENETIC STRUCTURE OF HIGH AND LOW RISK HUMAN PAPILLOMAVIRUSES CIRCULATING IN THE RUSSIAN FEDERATION." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-123.

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Stashko, T. V. "MAIN CLINICAL AND DEMOGRAPHIC COVID-19 INDICATORS DURING THE MAXIMUM SPREAD SARS-COV-2 PANDEMIC BY THE EXAMPLE OF THE INFECTIOUS HOSPITAL IN THE MOSCOW OBLAST." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-176.

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Bugorkova, S. A., E. A. Chumachkova, A. L. Kravtsov, S. A. Portenko, V. A. Kozhevnikov, A. Yu Goncharova, E. V. Naidenova, O. V. Kedrova, E. S. Kazakova, and S. A. Shcherbakova. "IMMUNOLOGICAL DISORDERS IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA DURING THE COVID-19 EPIDEMIC IN SARATOV OBLAST." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-127.

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Reports on the topic "Biosafety"

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King, Bruce W. Biosafety Manual. Office of Scientific and Technical Information (OSTI), May 2010. http://dx.doi.org/10.2172/983284.

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Siegel, Dina. Principles of Biosafety. Office of Scientific and Technical Information (OSTI), November 2022. http://dx.doi.org/10.2172/1900435.

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Caskey, Susan Adele, Jennifer M. Gaudioso, Reynolds Mathewson Salerno, Stefan M. Wagner, Mika Shigematsu, George Risi, Joe Kozlovac, Vibeke Halkjaer-Knudsen, and Esmeralda Prat. Biosafety Risk Assessment Methodology. Office of Scientific and Technical Information (OSTI), October 2010. http://dx.doi.org/10.2172/1325209.

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Dickens, Brian Scott, Melanie Ann Chavez, Donovan J. Heimer, Ryan Knudsen, and Celina Carmelita Velasquez. Biosafety Level 3 Recon Training. Office of Scientific and Technical Information (OSTI), April 2017. http://dx.doi.org/10.2172/1352397.

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Siegel, Dina. Principles of Biosafety Course # 31701. Office of Scientific and Technical Information (OSTI), September 2022. http://dx.doi.org/10.2172/1887109.

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Schuerger, Caroline, Sara Abdulla, and Anna Puglisi. Mapping Biosafety Level-3 Laboratories by Publications. Center for Security and Emerging Technology, August 2022. http://dx.doi.org/10.51593/20220019.

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Biosafety Level-3 laboratories (BSL-3) are an essential part of research infrastructure and are used to develop vaccines and therapies. The research conducted in them provides insights into host-pathogen interactions that may help prevent future pandemics. However, these facilities also potentially pose a risk to society through lab accidents or misuse. Despite their importance, there is no comprehensive list of BSL-3 facilities, or the institutions in which they are housed. By systematically assessing PubMed articles published in English from 2006-2021, this paper maps institutions that host BSL-3 labs by their locations, augmenting current knowledge of where high-containment research is conducted globally.
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Revill, James, and Kai Ilchmann. Assessing the SecBio Platform Proposal for the Biological Weapons Convention. UNIDIR, December 2022. http://dx.doi.org/10.37559/wmd/22/bwc/04.

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Biosecurity and biosafety are important aspects of the life sciences and they have been discussed in the Biological Weapons Convention (BWC) on several occasions. Moreover, several initiatives are underway to advance biosecurity and safety. However, these initiatives are often context specific and the effective implementation of biosecurity and biosafety measures around the globe remains inadequate. To address this gap, in 2022, France, Senegal and Togo submitted a revised proposal to the BWC for the “establishment of an international platform dedicated to biosecurity and biosafety: SecBio”. The proposal includes three pillars: a searchable repository for biosafety- and biosecurity-related materials; a learning module; and a forum for expert networking to exchange information, data and best practices. To this end, this report draws lessons from past initiatives to develop repositories, learning modules and expert forums in order to inform the development of the SecBio platform (and any such similar initiatives). The report begins with an overview of the importance of biosafety and biosecurity in the context of the BWC. It then proceeds to look at each of the platform pillars in turn, drawing from past experiences to identify lessons and develop options for state parties to consider.
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Serna, Kassandra, and Giulio M. Mancini. Draft Libya Legislative Framework for Biosafety and Biosecurity. Office of Scientific and Technical Information (OSTI), December 2014. http://dx.doi.org/10.2172/1173190.

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Research Institute (IFPRI), International Food Policy. Socioeconomic considerations in biosafety decisionmaking Methods and implementation. Washington, DC: International Food Policy Research Institute, 2013. http://dx.doi.org/10.2499/9780896292079.

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Siegel, Dina Mary. Biosafety- A Regulatory Primer for DOE/NNSA Sites. Office of Scientific and Technical Information (OSTI), May 2017. http://dx.doi.org/10.2172/1356119.

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