Relevant bibliographies by topics / Biophysical stimulation

Academic literature on the topic 'Biophysical stimulation'

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Published: 6 September 2023

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Journal articles on the topic "Biophysical stimulation"

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Wang, Feng-Sheng, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, and Wei-Shiung Lian. "Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics." Antioxidants 10, no. 9 (August 30, 2021): 1394. http://dx.doi.org/10.3390/antiox10091394.

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Bone-forming cells build mineralized microstructure and couple with bone-resorbing cells, harmonizing bone mineral acquisition, and remodeling to maintain bone mass homeostasis. Mitochondrial glycolysis and oxidative phosphorylation pathways together with ROS generation meet the energy requirement for bone-forming cell growth and differentiation, respectively. Moderate mechanical stimulations, such as weight loading, physical activity, ultrasound, vibration, and electromagnetic field stimulation, etc., are advantageous to bone-forming cell activity, promoting bone anabolism to compromise osteoporosis development. A plethora of molecules, including ion channels, integrins, focal adhesion kinases, and myokines, are mechanosensitive and transduce mechanical stimuli into intercellular signaling, regulating growth, mineralized extracellular matrix biosynthesis, and resorption. Mechanical stimulation changes mitochondrial respiration, biogenesis, dynamics, calcium influx, and redox, whereas mechanical disuse induces mitochondrial dysfunction and oxidative stress, which aggravates bone-forming cell apoptosis, senescence, and dysfunction. The control of the mitochondrial biogenesis activator PGC-1α by NAD+-dependent deacetylase sirtuins or myokine FNDC/irisin or repression of oxidative stress by mitochondrial antioxidant Nrf2 modulates the biophysical stimulation for the promotion of bone integrity. This review sheds light onto the roles of mechanosensitive signaling, mitochondrial dynamics, and antioxidants in mediating the anabolic effects of biophysical stimulation to bone tissue and highlights the remedial potential of mitochondrial biogenesis regulators for osteoporosis.
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Moretti, Lorenzo, Davide Bizzoca, Giovanni Angelo Giancaspro, Giuseppe Danilo Cassano, Francesco Moretti, Stefania Setti, and Biagio Moretti. "Biophysical Stimulation in Athletes’ Joint Degeneration: A Narrative Review." Medicina 57, no. 11 (November 4, 2021): 1206. http://dx.doi.org/10.3390/medicina57111206.

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Osteoarthritis (OA) is the most prevalent degenerative joint disease and the main cause of pain and disability in elderly people. OA currently represents a significant social health problem, since it affects 250 million individuals worldwide, mainly adults aged over 65. Although OA is a multifactorial disease, depending on both genetic and environmental factors, it is reported that joint degeneration has a higher prevalence in former athletes. Repetitive impact and loading, joint overuse and recurrent injuries followed by a rapid return to the sport might explain athletes’ predisposition to joint articular degeneration. In recent years, however, big efforts have been made to improve the prevention and management of sports injuries and to speed up the athletes’ return-to-sport. Biophysics is the study of biological processes and systems using physics-based methods or based on physical principles. Clinical biophysics has recently evolved as a medical branch that investigates the relationship between the human body and non-ionizing physical energy. A physical stimulus triggers a biological response by regulating specific intracellular pathways, thus acting as a drug. Preclinical and clinical trials have shown positive effects of biophysical stimulation on articular cartilage, subchondral bone and synovia. This review aims to assess the role of pulsed electromagnetic fields (PEMFs) and extracorporeal shockwave therapy (ESWT) in the prevention and treatment of joint degeneration in athletes.
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Somers, Sarah M., Alexander A. Spector, Douglas J. DiGirolamo, and Warren L. Grayson. "Biophysical Stimulation for Engineering Functional Skeletal Muscle." Tissue Engineering Part B: Reviews 23, no. 4 (August 2017): 362–72. http://dx.doi.org/10.1089/ten.teb.2016.0444.

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Herness, M. S. "Neurophysiological and biophysical evidence on the mechanism of electric taste." Journal of General Physiology 86, no. 1 (July 1, 1985): 59–87. http://dx.doi.org/10.1085/jgp.86.1.59.

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The phenomenon of electric taste was investigated by recording from the chorda tympani nerve of the rat in response to both electrical and chemical stimulations of the tongue with electrolytes in order to gain some insight into its mechanism on both a neurophysiological and biophysical basis. The maximum neural response levels were identical for an individual salt (LiCl, NaCl, KCl, or CaCl2), whether it was presented as a chemical solution or as an anodal stimulus through a subthreshold solution. These observations support the idea that stimulation occurs by iontophoresis of ions to the receptors at these current densities (less than 100 microA/cm2). Electric responses through dilute HCl were smaller than the chemically applied stimulations, but the integrated anodal responses appeared similar to chemical acid responses, as evidenced by an OFF response to both forms of stimuli. Hydrogen may be more permeant to the lingual epithelium and would thus be shunted away from the taste receptors during anodal stimulation. When the anion of electric taste was varied via subthreshold salt solutions, the response magnitude increased as the mobility of the anion decreased. The transport numbers of the salts involved adequately explains these differences. The physical aspects of ion migration occurring within the adapting fluid on the tongue are also discussed. Direct neural stimulation by the current appears to occur only at higher current densities (greater than 300 microA/cm2). If the taste cells of the tongue were inactivated with either iodoacetic acid (IAA) or N-ethyl maleimide (NEM), or removed with collagenase, then responses from the chorda tympani could be obtained only at these higher current densities. Latency measurements before and after IAA or NEM treatment corroborated these findings. The results are discussed in terms of several proposed mechanisms of electric taste and it is concluded that an ion accumulation mechanism can adequately explain the data.
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De Francesco, Francesco De, Pasquale Gravina, Stefano Varagona, Stefania Setti, Antonio Gigante, and Michele Riccio. "Biophysical Stimulation in Delayed Fracture Healing of Hand Phalanx: A Radiographic Evaluation." Biomedicines 10, no. 10 (October 9, 2022): 2519. http://dx.doi.org/10.3390/biomedicines10102519.

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Phalangeal fractures are common events among the upper limbs accounting for 10% of all human body fractures. Fracture complete healing process may persevere several months or years. Most phalangeal fractures present favorable union within 3 to 6 weeks. In the literature, biophysical stimulation has yielded favorable outcomes in the treatment of hand fractures. A survey involving hospitals in the US reported the use of biophysical stimulation (72%) in relation to nonhealing fractures at three months after trauma. A noninvasive procedure such as biophysical stimulation may be preferential prior to consideration of invasive procedures. In this retrospective study, we analyzed 80 phalangeal fractures, 43 of which did not show any radiographic sign of healing 30 days after surgery; on radiograms, we calculated radiographic data and the total active motion (TAM) for clinical comparison. All radiographic images were evaluated using Adobe Photoshop CS3 (version 10.0, Adobe Systems Inc., San Jose, CA, USA). We calculated the index of relative bone healing each month after surgery starting from 30 days, which was considered as T1, and followed up for a total of 6 months after stimulation (T6) with better results in stimulated groups. We concluded that prompt administration of biophysical stimulation supports fracture healing and yields an important improvement in the union rate compared with nontreatment. Above all, our patients experienced less injury-related distress between the fracture and repair period, which consequently reduced immobilization time, envisaging an early rehabilitation interval, with a better patient hand outcome.
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Kiran, Sneh, and Abha Rani Sinha. "Comparison of modified biophysical profile and vibroacoustic stimulation for intrapartum fetal assessment and prediction of perinatal outcome." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 4 (March 27, 2018): 1464. http://dx.doi.org/10.18203/2320-1770.ijrcog20181336.

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Background: Present study was undertaken to evaluate the effectiveness and safety of intrapartum modified biophysical profile along with vibroacoustic stimulation test in the assessment of fetal well-being compared with modified biophysical profile for women with a singleton pregnancy.Methods: This prospective study was carried out on a group of pregnant women of gestational age more than 35 weeks attending the labour room of obstetrics and gynecological department of Patna medical college and hospital, from October 2013 to October 2015. A total 220 pregnant women were selected and randomly divided into two groups, 110 women were given modified biophysical profile and 110 were underwent modified biophysical profile with VAST.Results: Among 110 women, who underwent modified biophysical profile, 80(72.7%) showed reactive response and 30(27.3%) showed non-reactive response. A total 110 women, in whom modified biophysical profile was combined with VAST, 100(91%) showed reactive response and 10 (9%) showed non-reactive response. Statistical comparison for predicting perinatal mortality was done. Modified biophysical profile with VAST had a high sensitivity (100% vs. 80%), specificity (92.5% vs. 75.2%), negative predictive value (100% vs. 98.7%) and positive predictive value (20% vs. 13.3%) as compared to modified biophysical profile. Test accuracy for predicting perinatal mortality was more than mBPP (92.7% vs.75.4%).Conclusions: Addition of VAST in place of NST in modified biophysical profile has high specificity & positive predictive value, shortens the testing time.
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Massari, Leo, Milena Fini, Ruggero Cadossi, Stefania Setti, and GianCarlo Traina. "Biophysical stimulation in osteonecrosis of the femoral head." Indian Journal of Orthopaedics 43, no. 1 (2009): 17. http://dx.doi.org/10.4103/0019-5413.45319.

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Opitz, Alexander, Arnaud Falchier, Gary S. Linn, Michael P. Milham, and Charles E. Schroeder. "Limitations of ex vivo measurements for in vivo neuroscience." Proceedings of the National Academy of Sciences 114, no. 20 (May 1, 2017): 5243–46. http://dx.doi.org/10.1073/pnas.1617024114.

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A long history of postmortem studies has provided significant insight into human brain structure and organization. Cadavers have also proven instrumental for the measurement of artifacts and nonneural effects in functional imaging, and more recently, the study of biophysical properties critical to brain stimulation. However, death produces significant changes in the biophysical properties of brain tissues, making an ex vivo to in vivo comparison complex, and even questionable. This study directly compares biophysical properties of electric fields arising from transcranial electric stimulation (TES) in a nonhuman primate brain pre- and postmortem. We show that pre- vs. postmortem, TES-induced intracranial electric fields differ significantly in both strength and frequency response dynamics, even while controlling for confounding factors such as body temperature. Our results clearly indicate that ex vivo cadaver and in vivo measurements are not easily equitable. In vivo examinations remain essential to establishing an adequate understanding of even basic biophysical phenomena in vivo.
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Modolo, Julien, Alexandre Legros, Alex W. Thomas, and Anne Beuter. "Model-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation." Interface Focus 1, no. 1 (November 17, 2010): 61–74. http://dx.doi.org/10.1098/rsfs.2010.0509.

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Electric stimulation has been investigated for several decades to treat, with various degrees of success, a broad spectrum of neurological disorders. Historically, the development of these methods has been largely empirical but has led to a remarkably efficient, yet invasive treatment: deep brain stimulation (DBS). However, the efficiency of DBS is limited by our lack of understanding of the underlying physiological mechanisms and by the complex relationship existing between brain processing and behaviour. Biophysical modelling of brain activity, describing multi-scale spatio-temporal patterns of neuronal activity using a mathematical model and taking into account the physical properties of brain tissue, represents one way to fill this gap. In this review, we illustrate how biophysical modelling is beginning to emerge as a driving force orienting the development of innovative brain stimulation methods that may move DBS forward. We present examples of modelling works that have provided fruitful insights in regards to DBS underlying mechanisms, and others that also suggest potential improvements for this neurosurgical procedure. The reviewed literature emphasizes that biophysical modelling is a valuable tool to assist a rational development of electrical and/or magnetic brain stimulation methods tailored to both the disease and the patient's characteristics.
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Rakovic, D. "Biophysical bases of the acupuncture and microwave resonance stimulation." Фізика живого (Біофізика і далі) 9, no. 1 (2001): 23–34.

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Dissertations / Theses on the topic "Biophysical stimulation"

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Hannay, Gwynne George. "Mechanical and electrical environments to stimulate bone cell development." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16285/1/Gwynne_Hannay_Thesis.pdf.

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Healthy bone is bombarded with many different mechanical strain derived signals during normal daily activities. One of these signals is present as a direct connective tissue strain on the cells. However, there is also the presence of an electrically charged streaming potential during this straining. The electrical potential is created from the movement of charged fluid through the small bone porosities. To date, little focus has been applied to elucidating the possible synergistic effects of these two stimulants. The aim of this project was to evaluate the effects of mechanical strain and indirect electrical stimulation upon the development of bone forming osteoblast cells and any possible synergistic effects of the two stimulants. This aim was achieved by using a novel device, designed and developed with the capability of creating a cell substrate surface strain along with an exogenous electrical stimulant individually or at the same time. Proliferation and differentiation were determined as a measure of cellular development. The indirect electrical stimulation was achieved through the use of a pulsed electromagnetic field (PEMF) while the mechanical strain was produced from dynamic stretching of a deformable cell substrate. Strain and strain rate were modelled from recent studies proposing that relatively high frequency, low strain osteogenic mechanical stimulants are more indicative of what healthy bone would be experiencing during normal activities. The PEMF signal mimicked a clinically available bone growth stimulator signal. Results showed a PEMF stimulus on monolayers of SaOS-2 and MG-63 osteoblast-like cells leads to a depression in proliferation. A concomitant increase in alkaline phosphatase production was also observed for the SaOS-2 cultures, but not for the MG-63 cell line. It was hypothesised that this was due to the MG-63's lack of phenotypic maturity compared to the SaOS-2 cells. Mechanical strain of the cell substrate alone, at a relatively high frequency (5Hz) but small strain, did not significantly effect either cell proliferation or differentiation for the MG-63 cells. However, when the electrical and mechanical stimulants were combined a significant increase in cellular differentiation occurred with MG-63 cultures, revealing a possible synergistic effect of these two stimulants on the development of bone cells.
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Hannay, Gwynne George. "Mechanical and electrical environments to stimulate bone cell development." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16285/.

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Healthy bone is bombarded with many different mechanical strain derived signals during normal daily activities. One of these signals is present as a direct connective tissue strain on the cells. However, there is also the presence of an electrically charged streaming potential during this straining. The electrical potential is created from the movement of charged fluid through the small bone porosities. To date, little focus has been applied to elucidating the possible synergistic effects of these two stimulants. The aim of this project was to evaluate the effects of mechanical strain and indirect electrical stimulation upon the development of bone forming osteoblast cells and any possible synergistic effects of the two stimulants. This aim was achieved by using a novel device, designed and developed with the capability of creating a cell substrate surface strain along with an exogenous electrical stimulant individually or at the same time. Proliferation and differentiation were determined as a measure of cellular development. The indirect electrical stimulation was achieved through the use of a pulsed electromagnetic field (PEMF) while the mechanical strain was produced from dynamic stretching of a deformable cell substrate. Strain and strain rate were modelled from recent studies proposing that relatively high frequency, low strain osteogenic mechanical stimulants are more indicative of what healthy bone would be experiencing during normal activities. The PEMF signal mimicked a clinically available bone growth stimulator signal. Results showed a PEMF stimulus on monolayers of SaOS-2 and MG-63 osteoblast-like cells leads to a depression in proliferation. A concomitant increase in alkaline phosphatase production was also observed for the SaOS-2 cultures, but not for the MG-63 cell line. It was hypothesised that this was due to the MG-63's lack of phenotypic maturity compared to the SaOS-2 cells. Mechanical strain of the cell substrate alone, at a relatively high frequency (5Hz) but small strain, did not significantly effect either cell proliferation or differentiation for the MG-63 cells. However, when the electrical and mechanical stimulants were combined a significant increase in cellular differentiation occurred with MG-63 cultures, revealing a possible synergistic effect of these two stimulants on the development of bone cells.
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Xing, Shu. "Intercellular communication between bone cells induced by mechanical stimulation." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114355.

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Mechanical loading is crucial in modulating the physiology and architecture of bone. Previous experiments indicated intercellular communication among osteoblasts upon mechanical stimulation, suggesting the involvement of a soluble signal mediator. Extracellular adenosine triphosphate (ATP) functions as signaling molecules in many cell regulation processes, therefore appears to be a prone candidate. ATP acts on osteoblasts through multiple P2 receptors. To provide insights on the roles of individual receptors, we modeled ATP concentration dependence for different P2 receptors. Next, the process of ATP degradation and the diffusion of ATP, adenosine diphosphate (ADP) and adenosine monophosphate (AMP) are modeled. To confirm the predictions of the model, we initiated experiments to measure ATP release from mechanically stimulated osteoblasts. Firefly luciferase assay successfully measures ATP using a luminometer and a charge coupled device (CCD) camera. Local indentation with a AFM cantilever is applied to mechanically stimulate an osteoblast. Preliminary results on real time imaging of ATP release from osteoblasts are reported.
Le chargement mécanique est crucial dans la modulation de la physiologie et de l'architecture de l'os. Des expériences antérieures ont indiqué la communication intercellulaire entre les ostéoblastes lors de la stimulation mécanique. Ces résultats suggèrent l'implication d'un médiateur soluble. L'adénosine triphosphate (ATP) extracellulaire fonctionne comme des molécules de signalisation dans de nombreux processus de régulation cellulaire. Celle-ci semble être un candidat à risque. L'ATP agit sur les ostéoblastes via les récepteurs P2. Ici, la concentration d'ATP pour chacun de ces récepteurs P2 a été modélisée mathématiquement pour mieux comprendre leur rôle. Le processus de dégradation de l'ATP et la diffusion de l'ATP, adénosine diphosphate (ADP) et adénosine monophosphate (AMP) ont aussi été modélisés. Avec le luminomètre, nous étions capables de mesurer avec succès l'ATP par dosage de la luciférase de luciole. Des images de haute résolution de la détection d'ATP ont été obtenues avec un dispositif à transfert de charge (CCD). Enfin, l'indentification locale avec une pointe de microscopie à force atomique (MFA) est appliquée mécaniquement pour stimuler un ostéoblaste. Les résultats préliminaires sur l'imagerie en temps réel de la libération d'ATP à partir d'ostéoblastes sont présentés.
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Huang, Huang. "Integrin Adhesion Response to Chemical and Mechanical Stimulation." Thesis, University of Missouri - Columbia, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13877168.

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Garnham, Carolyn Wendy. "A study of aspects of nerve stimulation with time-varying magnetic fields." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245642.

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Khayat, Ghazaleh. "Low frequency stimulation of stem cells in dynamic culture modulates differentiation pathways." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119594.

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Living cells, depending on their physiological functions, are subjected to a variety of mechanical stimulation. The magnitude and frequency of such mechanical stimulation varies dramatically in different organs. Oscillatory mechanical stimulation at relatively high frequancies, as occurs in walking, respiration and circulation, is one of the most extensively studied schemes. However, the stimulation at extremely low frequencies is rarely examined. This research investigates the effects of relatively low frequency mechanical stimulation in molecular scale, on different cell types. Throughout the work presented in this document, the emphasis was on the stem cells differentiation, and primary cells dedifferentiation. The results suggested that performing extremely slow activities, namely low frequency movements, significantly affects the differentiation pathways of stem cells. In addition, it was found that slow movement of surface culture area enhances phenotypical characteristics of primary cells.
Toutes les cellules vivantes, selon leur fonctions physiologiques, sont soumises à différentes stimulations mécaniques. L'ampleur et la fréquence de ces stimulations mécaniques varies considérablement d'un organe à un autre. Les stimulations oscillantes dues notamment à la marche, la respiration et la circulation sanguine sont largement étudiées. Par contre, les travaux concernant les stimulations a très faibles fréquences sont rare. Cette recherche examine les effets sur différents types de molécules, des stimulations mécaniques à relativement basse fréquence, à l'échelle moléculaire. Tout au long du travail présenté ici, l'accent a été mis sur la différenciation des cellules souches et la dedifférenciation des cellules primaires. Les résultats suggèrent que la pratique d'activités extrêmement lentes, à savoir les mouvements à basse fréquence, affectent, de manière significative, le mécanisme de différentiation des cellules souches. En outre, il a été constaté que les mouvements lents à la surface des cultures améliorent les caractéristiques phénotypiques des cellules primaires.
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Bin, Abdulwahab Sami S. A. "The use of Functional Electrical Stimulation (FES) in maintaining or improving the ability to stand and transfer in people with Multiple Sclerosis." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316398.

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Yue, Zhang. "Opto-Magneto-Electrical Nanoactuators for Wireless Cell Stimulation." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/670924.

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Clinical treatments based on electrical stimulation of excitable cells have been efficacious for a variety of diseases. However, these devices are often limited by their bulkiness, need for wiring electrodes and inability to target specific cells. Implantable devices that can directly convert optical or magnetic energy to localized electrical output to actuate cells are promising alternatives. This thesis focused on the development of opto-electric and magneto-opto-electric nanomaterials for wireless cell stimulation. Currently, the opto-electric stimulators usually require low penetration visible light and high intensities, the magneto-electric stimulators usually provide poor spatial and temporal precision. In this thesis, two types of nanomaterials have been developed to overcome these challenges. The first nanomaterial was based on Si/Au nanopillars to achieve opto-electric stimulation in the first and second NIR biological windows with ultralow light intensities. We started with the rational design and analysis, the FDTD simulations predicted that Si nanopillars capped by Au nanodiscs exhibited 6-fold enhancement of the light absorption compared with the plain Si wafer, such enhancement is due to the excitation of novel hybrid metal/dielectric resonances. Next, an exhaustive experimental opto-electric-chemical analysis of Si/Au nanostructures was presented. In particular, the short Si/Au nanopillars gave the highest opto-electric performance, achieving a photovoltage of 80 mV at ultralow light intensity of 0.44 µW/mm2, showing a frequency window of 50-200 Hz to maximize the photovoltage and photocurrent. Finally, the biocompatibility of the Si/Au nanostructures was validated by cell viability assays. The second nanomaterial was composed of arrays of hollow FeGa/ZnO nanodomes integrated onto soft, flexible and biocompatible elastomeric film. The proposed magneto-electric stimulation is based on the magnetostriction of FeGa and the piezoelectricity of ZnO, the opto-electric stimulation is based on the NIR light absorption of FeGa and the pyroelectric response of ZnO. The magnetic behaviour results revealed that the hexagonal-close-packed arrays with 400 nm diameter provided the lowest saturation magnetic field and minimal remanence. The photothermal test showed intense optical heating for light wavelengths of 808 nm and 1064 nm. The biocompatibility was proved by evaluating the bone Saos-2 cells viability. Therefore, the Si/Au and FeGa/ZnO nanoactuators present new platforms for wireless cell modulation through NIR light and magnetic field, which may be broadly applicable to both fundamental biological studies and clinical therapeutics.
Los tratamientos clínicos basados en la estimulación eléctrica de células excitables han sido eficaces y ampliamente utilizados para una variedad de enfermedades. Sin embargo, estos dispositivos a menudo están limitados por su volumen, la necesidad de electrodos con cableado externo y la incapacidad de actuar en células específicas. Los dispositivos implantables que pueden convertir la energía óptica o magnética en estímulos localizados eléctricos o térmicos para activar las células, son alternativas prometedoras. Esta tesis se centró en el desarrollo de nanomateriales opto-eléctricos y magneto-opto-eléctricos para la estimulación celular inalámbrica. Actualmente, los estimuladores opto-eléctricos generalmente requieren luz visible de baja penetración y altas intensidades, y los estimuladores magnetoeléctricos generalmente proporcionan una precisión espacial y temporal deficiente. En esta tesis, se han desarrollado dos tipos de nanomateriales para superar estos desafíos. El primer nanomaterial se basó en nanopilares Si/Au para lograr la estimulación opto-eléctrica en la primera y segunda ventanas biológicas del infrarrojo cercano con intensidades de luz ultrabajas. Las simulaciones teóricas predijeron que los nanopilares de Si coronados por nanodiscos Au exhiben una mejora de 6 veces en la absorción de luz en comparación con la oblea de Si simple. Tal mejora se debe a la excitación de nuevas resonancias híbridas de metal/dieléctrico. A continuación, se presentó un exhaustivo análisis experimental opto-eléctrico-químico de los nanopilares de Si/Au. Los nanopilares cortos de Si/Au dieron el mayor rendimiento opto-eléctrico, logrando un fotovoltaje de 80 mV a una intensidad de luz ultrabaja de 0,44 µW/mm2, que fue 11 veces mayor que la oblea p-n Si simple. La fotocorriente también mostró una mejora sustancial de 2.5 veces, mostrando una combinación de corrientes capacitivas y faradaicas inducidas por la luz que pueden ajustarse con la densidad de los nanopilares Si/Au. Además, los nanopilares cortos de Si/Au mostraron una ventana de frecuencia de 50-200 Hz para maximizar la fotovoltaje y la fotocorriente. Finalmente, la biocompatibilidad de las nanoestructuras Si/Au fue validada por ensayos de viabilidad celular. El segundo nanomaterial estaba compuesto por matrices de nanocúpulas huecas de FeGa/ZnO integradas en una película elastomérica flexible y biocompatible. La estimulación magnetoeléctrica propuesta se basa en la magnetostricción del FeGa y la piezoelectricidad del ZnO. La estimulación optoeléctrica se basa en la absorción de luz infrarroja por el FeGa y la respuesta piroeléctrica del ZnO. Los resultados del comportamiento magnético revelaron que las matrices hexagonales empaquetadas con un diámetro de 400 nm proporcionaron el campo magnético de saturación más bajo y una remanencia mínima. El análisis fototérmico mostró un intenso calentamiento óptico para longitudes de onda de luz de 808 nm y 1064 nm. La biocompatibilidad se demostró evaluando la viabilidad de las células Saos-2 óseas. En conclusión, los actuadores celulares nanoestructurados de Si/Au y FeGa/ZnO constituyen nuevas plataformas para la modulación electrofisiológica inalámbrica mediante luz infrarroja y campo magnético. Mirando hacia el futuro, son prometedores como nanoactuadores inyectables e implantables in vivo debido a las posibles optimizaciones, como la fabricación en sustratos flexibles y la funcionalización de su superficie para su unión a tipos celulares específicos, que podrían ser ampliamente aplicables tanto a los estudios biológicos fundamentales como a terapias clínicas.
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Valiulis, Vladas. "The effect of transcranial magnetic stimulation on brain bioelectrical activity." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140925_135043-14839.

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Transcranial magnetic stimulation (TMS) is a modern non invasive method of drug resistant psychiatric disorder treatment. TMS physiology research is hindered by variable, often controversial results. In most studies main attention is being focused on immediate effects after single TMS procedure rather than the influence of a complete therapy course. It is considered that variability of results in TMS practice is caused by different stimulation parameters and imprecision of stimulated area placement in the brain. Although TMS therapy is often viewed as a milder alternative to electroconvulsive therapy (ECT), comparative physiological studies of these two methods are very rare. The aim of this study was to evaluate the effect of rTMS therapy course on bioelectrical brain activity and compare it to an ECT effect. Research included the effect of high and low frequency (10 Hz and 1 Hz) TMS on EEG band power spectrum and auditory evoked potential P300, using both standard and neuronavigated target positioning. TMS evoked EEG changes were also compared to the changes of ECT. Change dynamics after several months of TMS therapy were also measured. Results showed that after TMS therapy the most notable change in the brain occurs in the form of delta power increase. When using standard positioning 10 Hz TMS evokes more diverse and intense EEG band power spectrum changes than the 1 Hz TMS. Application of neuronavigation system decreases theta and alpha band power changes in 10 Hz TMS... [to full text]
Transkranijinė magnetinė stimuliacija (TMS) – tai modernus neinvazinis vaistams rezistentiškų psichiatrinių sutrikimų gydymo būdas. Fiziologiniai TMS tyrimai pasižymi įvairiais, dažnai prieštaringais rezultatais, daugeliu atvejų didžiausias dėmesys skiriamas betarpiškiems poveikiams po vienos TMS procedūros, bet ne po pilno terapinio kurso. Manoma, kad rezultatų įvairovę TMS praktikoje įtakoja skirtingi stimuliacijos parametrai ir netikslumai parenkant stimuliuojamą zoną smegenyse. Nors TMS terapija dažnai traktuojama kaip švelnesnė alternatyva elektros impulsų terapijai (EIT), palyginamųjų fiziologinių šių metodikų tyrimų labai trūksta. Darbo tikslas buvo įvertinti TMS terapijos kurso poveikį bioelektriniam galvos smegenų aktyvumui ir palyginti jį su EIT terapijos poveikiu. Buvo tirta aukšto ir žemo dažnių (10 Hz ir 1 Hz) TMS terapijos įtaka EEG dažnių galios spektrui bei sukeltiniam klausos potencialui P300, naudojant standartinį ir neuronavigacinį taikinio pozicionavimą. TMS sukelti EEG pokyčiai palyginti su EIT terapijos sukeltais EEG pokyčiais, išmatuota TMS terapijos sąlygotų pokyčių dinamika kelių mėnesių bėgyje. Rezultatai parodė, kad TMS terapijos pasekoje smegenyse ryškiausiai padidėja delta dažnio galia. Naudojant standartinį pozicionavimą 10 Hz TMS sukėlė įvairesnius ir intensyvesnius EEG galios spektro pokyčius nei 1 Hz TMS. Pritaikius neuronavigacinę sistemą 10 Hz TMS atveju sumažėjo teta ir alfa dažnių galios pokyčiai. Praėjus keliems mėnesiams nuo TMS... [toliau žr. visą tekstą]
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Ment, Stephanie. "Effects of seven days of continuous capacitive electrical stimulation on bone growth around titanium implants in the rat tibia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0035/MQ64407.pdf.

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Books on the topic "Biophysical stimulation"

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Rosenberg, Nahum. Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8.

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Behari, Jitendra. Biophysical bone behavior. Singapore: John Wiley, 2009.

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service), SpringerLink (Online, ed. Cochlear Mechanics: Introduction to a Time Domain Analysis of the Nonlinear Cochlea. Boston, MA: Springer US, 2012.

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He, Bin. Neural Engineering. 2nd ed. Boston, MA: Springer US, 2013.

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Rosenberg, Nahum. Autologous Bone Grafting and Regeneration: Clinical Applications of Biophysical Osteoblast Stimulation. Springer International Publishing AG, 2022.

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TENS equipment, techniques, and biophysical principles. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199673278.003.0003.

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The purpose of the electrical current delivered during TENS is to generate nerve impulses in peripheral nerve fibres to modulate the flow of nociceptive information and reduce pain. The characteristics of the electrical currents (i.e. stimulating parameters) and physiology at the electrode–skin interface will influence which nerve fibres are excited. Conventional TENS and acupuncture-like TENS are two techniques developed to stimulate different types of nerve fibres. The purpose of this chapter is to overview the biophysical principles of TENS and to explain how these principles have been used to inform clinical practice by covering TENS equipment and the standard TENS device, the electrical characteristics of currents produced by a standard TENS device, lead wires and electrodes, the physiology at the electrode–skin interface including nerve fibre activation by TENS, and TENS techniques used in clinical practice, including conventional TENS and acupuncture-like TENS (AL-TENS).
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Stegeman, Dick F., and Michel J. A. M. Van Putten. Recording of neural signals, neural activation, and signal processing. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199688395.003.0005.

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This chapter discusses recording of electrophysiological signals in the context of clinical neurophysiology. We first discuss the interpretation of signals and differences between signals in terms of their underlying (electro)physiology. As a most prominent aspect of applied electrophysiology, the biophysics of volume conduction in extracellular space is discussed. We also present some basics of advanced procedures to analyse neurophysiological data. Aspects of electrical stimulation are treated too, including recent developments in diagnostic and therapeutic constant current stimulation. We finally discuss the background of hazardous electric currents and the safety of bioelectric equipment. Aspects that are relevant in the digitization and post-processing of data are briefly reviewed.
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Electric treatment of hemorrhoids. San Diego, California, USA: Rick A. Shacket, 1989.

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Implantable Neural Prostheses 2 Techniques And Engineering Approaches. Springer, 2010.

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He, Bin. Neural Engineering. Springer, 2013.

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Book chapters on the topic "Biophysical stimulation"

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Loffler, Susanne, and J. Luis Luján. "Chapter 2 Biophysical Fundamentals of Neural Excitation." In Deep Brain Stimulation, 25–50. Pan Stanford Publishing Pte. Ltd. Penthouse Level, Suntec Tower 3 8 Temasek Boulevard Singapore 038988: Pan Stanford Publishing, 2016. http://dx.doi.org/10.1201/9781315364759-3.

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Rosenberg, Nahum. "The Theoretical Context of Biophysical Stimulation of Osteoblasts." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 3–12. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_1.

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Rosenberg, Nahum. "Selected Research Methodologies of Biophysical Stimulation of Osteoblast." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 13–36. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_2.

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Ryaby, James T. "Biophysical Stimulation Using Electrical, Electromagnetic, and Ultrasonic Fields." In Bone Regeneration and Repair, 291–309. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-863-3:291.

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Rosenberg, Nahum. "Evolving Clinical Modalities for Bone Regeneration by Biophysical Stimulation." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 71–73. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_9.

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Rosenberg, Nahum. "Determination of In Vitro Generated Bone Tissue." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 37–43. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_3.

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Rosenberg, Nahum. "To Summarize." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 75–76. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_10.

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Rosenberg, Nahum. "The Clinical Potential of the In Vitro Generated Bone-Like Tissue." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 49–54. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_5.

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Rosenberg, Nahum. "Distraction Osteogenesis." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 65–69. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_8.

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Rosenberg, Nahum. "The Osseointegration Potential of Engineered Bone-Like Tissue μm." In Biophysical Osteoblast Stimulation for Bone Grafting and Regeneration, 45–47. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-06920-8_4.

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Conference papers on the topic "Biophysical stimulation"

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Vdovina, Nadezhda, Stanislav Darovskikh, and Darya Kochkina. "A Biophysical Approach to the Prevention of Cancer Diseases." In Special Session on Non-invaisive Neuro-stimulation in Neurorehabilitation Tasks. SCITEPRESS - Science and Technology Publications, 2019. http://dx.doi.org/10.5220/0007411605590563.

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Beyeler, Michael. "Biophysical model of axonal stimulation in epiretinal visual prostheses." In 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER). IEEE, 2019. http://dx.doi.org/10.1109/ner.2019.8716969.

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Mahadevan-Jansen, Anita. "Insight into the Biophysical Mechanisms of Infrared Neural Stimulation." In Optics and the Brain. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/brain.2016.bm2d.2.

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Ryaby, James T., Robert J. Fitzsimmons, Frank P. Magee, Allan M. Weinstein, and David J. Baylink. "Biophysical stimulation of tissue healing mediated by IGF-II." In 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.5760963.

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Ryaby, Fitzsimmons, Magee, and Weinstein. "Biophysical Stimulation Of Tissue Healing Mediated By IGF-II." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.589710.

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Fernandes, Sofia R., João Meneses, Abhishek Datta, Sandra Amado, Nuno Alves, and Paula Pascoal-Faria. "Comparison of electromagnetic stimulation fields generated by different experimental setups: A biophysical analysis." In INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS ICNAAM 2020. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0081338.

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Mofrad, Mohammad R. K. "Molecular Mechanosensors and Focal Adhesion Mechanotransduction." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19707.

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Cellular response to mechanical stimulation is mediated by both biochemical mechanisms via changes in gene expression and by biophysical mechanisms via mechanically induced changes in specific molecules’ structure and function. These mechanically responsive molecules can be described as the cell’s mechanosensors and can function to initiate processes such as focal adhesion formation. A series of molecular dynamics investigations explore the mechanosensor function of key molecules involved in focal adhesion formation and cytoskeletal dynamics.
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Jiang, Fuchang, Bach T. Nguyen, Behzad Elahi, Julie Pilitsis, and Laleh Golestanirad. "Effect of Biophysical Model Complexity on Predictions of Volume of Tissue Activated (VTA) during Deep Brain Stimulation." In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) in conjunction with the 43rd Annual Conference of the Canadian Medical and Biological Engineering Society. IEEE, 2020. http://dx.doi.org/10.1109/embc44109.2020.9175300.

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"BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION." In International Conference on Bio-inspired Systems and Signal Processing. SciTePress - Science and and Technology Publications, 2008. http://dx.doi.org/10.5220/0001062300520057.

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Mishchenko, Mikhail A., Denis I. Bolshakov, Valery V. Matrosov, and Ilya V. Sysoev. "Excitation of electronic neuron-like generator with pulse stimulation." In Computational Biophysics and Nanobiophotonics, edited by Boris N. Khlebtsov and Dmitry E. Postnov. SPIE, 2022. http://dx.doi.org/10.1117/12.2625963.

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Reports on the topic "Biophysical stimulation"

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Anderson, William S., and Pawel Kudela. Biophysical Model of Cortical Network Activity and the Influence of Electrical Stimulation. Fort Belvoir, VA: Defense Technical Information Center, October 2015. http://dx.doi.org/10.21236/ad1008305.

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