Dissertations / Theses on the topic 'Biomedical fluid mechanics'
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Kumar, Krishna Nandan. "Acoustic Studies on Nanodroplets, Microbubbles and Liposomes." Thesis, The George Washington University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10639706.
Full textMicrobubbles and droplets are nanometer to micron size biocompatible particles which are primarily used for drug delivery and contrast imaging. Our aim is to broaden the use of microbubbles from contrast imaging to other applications such as measuring blood pressure. The other goal is to develop in situ contrast agents (phase shift droplets) which can be used for applications such as cancer tumor imaging. Therefore, the focus is on developing and validating the concept using experimental and theoretical methods. Below is an overview of each of the projects performed on droplets and microbubbles.
Phase shift droplets vaporizable by acoustic stimulation offer many advantages over microbubbles as contrast agents due to their higher stability and possibility of smaller sizes. In this study, the acoustic droplet vaporization (ADV) threshold of a suspension of PFP droplets (400-3000nm) was acoustically measured as a function of the excitation frequency by examining the scattered signals, fundamental, sub- and second-harmonic. This work presents the experimental methodology to determine ADV threshold. The threshold increases with frequency: 1.25 MPa at 2.25 MHz, 2.0 MPa at 5 MHz and 2.5 MPa at 10 MHz. The scattered response from droplets was also found to match well with that of independently prepared lipid-coated microbubble suspension in magnitude as well as trends above the threshold value. Additionally, we have employed classical nucleation theory (CNT) to investigate the ADV, specifically the threshold value of the peak negative pressure required for vaporization. The theoretical analysis predicts that the ADV threshold increases with increasing surface tension of the droplet core and frequency of excitation, while it decreases with increasing temperature and droplet size. The predictions are in qualitative agreement with experimental observations.
A technique to measure the ambient pressure using microbubbles was developed. Here we are presenting the results of an in vitro study aimed at developing an ultrasound-aided noninvasive pressure estimation technique using contrast agents--Definity®, a lipid coated microbubble, and an experimental PLA (Poly lactic acid) microbubbles. Scattered responses from these bubbles have been measured in vitro as a function of ambient pressure using a 3.5 MHz acoustic excitation of varying amplitude. At an acoustic pressure of 670 kPa, Definity ® microbubbles showed a linear decrease in subharmonic signal with increasing ambient pressure, registering a 12dB reduction at an overpressure of 120 mm Hg. Ultrasound contrast microbubbles experience widely varying ambient blood pressure in different organs, which can also change due to diseases. Pressure change can alter the material properties of the encapsulation of these microbubbles. Here the characteristic rheological parameters of contrast agent Definity and Targestar are determined by varying the ambient pressure (in a physiologically relevant range 0-200 mmHg). Four different interfacial rheological models are used to characterize the microbubbles. Both the contrast agents show an increase in their interfacial dilatational viscosity and interfacial dilatational elasticity with ambient pressure.
It has been well established that liposomes prepared following a careful multi-step procedure can be made echogenic. Our group as well as others experimentally demonstrated that freeze-drying in the presence of mannitol is a crucial component to ensure echogenicity. Here, we showed that freeze-dried aqueous solutions of excipients such as mannitol, meso-erythritol, glycine, and glucose that assume a crystalline state, when dispersed in water creates bubbles and are echogenic even without any lipids. We also present an explanation for the bubble generation process because of dissolution of mannitol.
Langeard, Olivier. "Numerical study of a Navier-Stokes flow through a fibrous porous medium." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/15944.
Full textYousefi, Koupaei Atieh. "Biomechanical Interaction Between Fluid Flow and Biomaterials: Applications in Cardiovascular and Ocular Biomechanics." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595335168435434.
Full textKadel, Saurav. "Computational Assessment of Aortic Valve Function and Mechanics under Hypertension." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1594243694736478.
Full textNasar, Abouzied. "Eulerian and Lagrangian smoothed particle hydrodynamics as models for the interaction of fluids and flexible structures in biomedical flows." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/eulerian-and-lagrangian-smoothed-particle-hydrodynamics-as-models-for-the-interaction-of-fluids-and-flexible-structures-in-biomedical-flows(507cd0db-0116-4258-81f2-8d242e8984fa).html.
Full textShrestha, Liza. "CFD study on effect of branch sizes in human coronary artery." Thesis, University of Iowa, 2010. https://ir.uiowa.edu/etd/885.
Full textCopploe, Antonio. "Bioengineered Three-dimensional Lung Airway Models to Study Exogenous Surfactant Delivery." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1505482360585247.
Full textBenmadda, El Mostafa. "Etude de l'ecoulement pulse d'un fluide incompressible dans une conduite elastique : application a la circulation arterielle." Poitiers, 1987. http://www.theses.fr/1987POIT2267.
Full textKaul, Himanshu. "A multi-paradigm modelling framework for simulating biocomplexity." Thesis, University of Oxford, 2013. https://ora.ox.ac.uk/objects/uuid:a3e6913d-b4c1-49fd-88fb-7e7155de2e2f.
Full textSmith, Amy. "Multi-scale modelling of blood flow in the coronary microcirculation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e6f576a2-75d9-4778-a640-a1e8551141a6.
Full textMcCormick, Matthew. "Ventricular function under LVAD support." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:0d49ba30-b508-4c69-9ba6-b398d4338c01.
Full textChambers, Andrea Marie. "Stressed and Strung Out: The Development and Testing of an In Vivo Like Bench-top Bioreactor for the Observation of Cells Under Shear Stress." University of Dayton / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1438218205.
Full textLouison, Charles Davidson. "A biomedical device business plan for Medicraften Devices Inc. to develop a fluid medication dispenser." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36730.
Full textIncludes bibliographical references (leaf 32).
This thesis surrounds an analysis to understand what it would take for a company to successfully launch a prescription fluid dispensing device. This device would in theory be able to dispense medication at any time daily in correspondence to a patient's prescription. This thesis does not surround the actual development of a prototype, but gives a clear background into its technology. Other areas of research in this report include potential alliances and acquisitions of this company. This report gives a background into the target market, how the market will benefit from this device, and who the potential competitors of this device could be. Also explored are a potential advisory board for this company and how staff will be organized. Although the people on the advisory board and company's staff do exist, they are not actually involved in the conception of the thesis' device. This thesis uses techniques learned in management, engineering, and biomedical enterprise courses at MIT to give a real world case of how an effective biomedical device company can be formed and effectively managed.
by Charles Davidson Louison.
S.B.
Ranga, Adrian. "Fluid-structure interaction in the aortic valve : implications for surgery and prosthesis design." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83925.
Full textHosseinipour, Milad. "Design and Development of an Intra-Ventricular Assistive Device For End Stage Congestive Heart Failure Patients: Conceptual Design." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1372726495.
Full textDoyle, Matthew G. "Simulation of blood flow in a ventricular assist device with fluid-structure interaction effects." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26630.
Full textShaffer, Nicholas. "Magnetic Resonance Image-Based Hydrodynamic Analysis of Cerebrospinal Fluid Motion in Type I Chiari Malformation." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1417545898.
Full textVan, der Merwe Schalk Willem. "A MEMS based valveless micropump for biomedical applications." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4230.
Full textENGLISH ABSTRACT: The valveless micropump holds great potential for the biomedical community in applications such as drug delivery systems, blood glucose monitoring and many others. It is also a critical component in many a lab-on-a-chip device, which in turn promises to improve our treatment and diagnosis capabilities for diseases such as diabetes, tuberculosis, and HIV/AIDS. The valveless micropump has attracted attention from researchers on the grounds of its simple design, easy manufacturability and sensitive fluid handling characteristics, which are all important in biomedical applications. The pump consists of a pump chamber with a diffuser and nozzle on opposing sides of the pump chamber. The flow into the diffuser and nozzle is induced by an oscillating piezoelectric disc located on top of the pump chamber. The nozzle and diffuser rectify the flow in one direction, due to different pressure loss coefficients. The design process however is complex. In this study, we investigate the characteristics of a diffuser / nozzle based micropump using detailed computational fluid dynamic (CFD) analyses. Significant parameters are derived using the Buckingham-Pi theorem. In part based on this, the respective shapes of the diffuser and of the nozzle of the micropump are selected for numerical investigation. Hence the influence of the selected parameters on the flow rate of the micropump is studied using three-dimensional transient CFD analyses. Velocity profiles from the CFD simulations are also compared to the Jeffery-Hamel solution for flow in a wedge shaped channel. Significant similarities exist between the data and the predicted Jeffery-Hamel velocity profiles near the exit of the diffuser. Three different diffuser geometries were simulated at three frequencies. The flow rate and direction of flow are shown to be highly sensitive to inlet and outlet diffuser shapes, with the absolute flow rate varying by as much as 200% for the geometrical perturbations studied. Entrance losses at both the diffuser inlet and nozzle inlet appear to dominate the flow resistance at extremely laminar flow conditions with the average Reynolds number of Reave ≈ 500.
AFRIKAANSE OPSOMMING: Die kleplosemikropomp hou groot potensiaal in vir die biomediese gemeenskap in toepassings soos medisyne dosering sisteme, bloed glukose monitering en baie ander. Dit is ook ’n kritiese komponent in “lab-on-chip” sisteme, wat beloof om die behandeling en diagnose van siektes soos suikersiekte, tuberkulose enMIV/VIGS te verbeter. Die kleplose mikropomp het tot dusver die aandag van navorsers geniet as gevolg van sy eenvoudige ontwerp, maklike vervaardiging en sensitiewe vloeistof hantering. Hierdie kenmerke is krities inmenige biomediese toepassings. Die pomp bestaan uit ’n pompkamer met ’n diffusor en ’n mondstuk aan teenoorstaande kante van die pompkamer. Vloei in die diffusor en mondstuk in word geinduseer deur ’n ossillerende piëso-elektiese skyf wat bo-op die pompkamer geleë is. Weens verskillende druk verlies koëffisinëte van die diffusor en diemondstuk word die vloei in een rigting gerig. Die ontwerp-proses is egter kompleks. In hierdie studie word die eienskappe van die diffusor /mondstuk ondersoek deur gebruik temaak van gedetailleerde numeriese vloei-dinamiese analises. Belangrike parameters word afgelei deur gebruik te maak van die Buckingham-Pi teorema. Gedeeltelik gebaseer hierop word die onderskeidelike vorms van die diffusor en die mondstuk van die mikropomp geselekteer vir numeriese ondersoek. Gevlolglik word die invloed van die geselekteerde parameters op die vloei tempo van diemikropomp ondersoek deur gebruik temaak van drie-dimensionele tyd afhanklike numeriese vloei-dinamiese analises. Snelheids profiele van hierdie simulasiesword vergelykmet die Jeffrey-Hamel oplossing vir die vloei in ’n wigvormige kanaal. Daar is oorwegende ooreenkomstighede tussen hierdie data en die voorspelde Jeffrey-Hamel snelheids profiele veral by die uitgang van die diffusor. Drie verskillende diffusor vorms is by drie frekwensies gesimuleer. Daar is bewys dat die vloei tempo en vloeirigting baie sensitief is vir inlaat- en uitlaat diffusor vorms en dat die absolute vloei tempo kan varieermet soveel as 200%vir die geometriese versteuringswat ondersoek is. Inlaat verliese by beide die diffusor inlaat en die mondstuk inlaat, blyk om die vloei weerstand te domineer waar die vloei uiters laminêr ismet ’n gemiddelde Reynolds getal van Regem ≈ 500
Heidari, Pahlavian Soroush. "Non-Invasive Assessment of Cerebrospinal Fluid and Brain Tissue Biomechanics using MRI and Computational Modeling." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522060187703491.
Full textRidzon, Matthew C. "Quantifying Cerebellar Movement With Fluid-Structure Interaction Simulations." University of Akron / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1590752448366714.
Full textCudjoe, Edward. "Tribocorrosion Behavior of Metallic Implants: A Comparative Study of CoCrMo and Ti6Al4V in Simulated Synovial Fluids." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu156634015910627.
Full textTHYAGARAJ, SURAJ. "In Vitro Investigation Of Cerebrospinal Fluid Dynamics In Chiari Malformation By 4D Phase Contrast MRI." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1462548992.
Full textSethaput, Thunyaseth. "Mathematical Model for Hemodynamic and Intracranial Windkessel Mechanism." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1363149368.
Full textTakaddus, Ahmed Tasnub. "Numerical Investigations of Unobstructed and Obstructed Human Ureter Peristalsis." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1516150297659937.
Full textShupe, Andrew C. "Convective Flow Patterns of a Three Generation Bifurcation Model." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1353035707.
Full textTorkaman, Saeed. "Experimental and Computational Study of Intraglottal Pressures in a Three-Dimensional Model with a Non-Rectangular Glottal Shape." University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302011788.
Full textCelestin, Carey Jr. "Computational Fluid Dynamics Applied to the Analysis of Blood Flow Through Central Aortic to Pulmonary Artery Shunts." ScholarWorks@UNO, 2015. http://scholarworks.uno.edu/td/1972.
Full textChen, Xiaodong. "Fluid-Structure Interaction Modeling of Epithelial Cell Deformation during Microbubble Flows in Compliant Airways." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332208862.
Full textMcElroy, Mark Allen. "A Procedure for Generating Finite Element Models (FEM) of Abdominal Aortic Aneurysms with Fluid Boundary Conditions Derived from Magnetic Resonance Imaging (MRI) Velocimetry." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1284670607.
Full textSheer, Francis Joseph. "Multi-Scale Computational Modeling of Fluid-Structure Interactions and Adhesion Dynamics in the Upper Respiratory System." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316287639.
Full textIBRAHIMY, ALAADDIN. "Computational Methodology to Estimate Resistance to Cerebrospinal Fluid Motion in the Spinal Canal for Chiari Patients with Specific and Nonspecific Symptoms." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1574449883152461.
Full textYun, Brian Min. "Simulations of pulsatile flow through bileaflet mechanical heart valves using a suspension flow model: to assess blood damage." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/53378.
Full textRahman, Roussel. "Analysis and Sensitivity Study of Zero-Dimensional Modeling of Human Blood Circulation Network." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1494769445938849.
Full textLiu, Janet. "Design of a Novel Tissue Culture System to Subject Aortic Tissue to Multidirectional Bicuspid Aortic Valve Wall Shear Stress." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527077368757049.
Full textRifai, Bassel. "Cavitation-enhanced delivery of therapeutics to solid tumors." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:374b2ee1-0711-4994-8434-bf90358d9e47.
Full textWright, Darrel W. "Pressure losses experienced by liquid flow through straight PDMS microchannels of varying diameters." Honors in the Major Thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1527.
Full textBachelors
Engineering and Computer Science
Mechanical Engineering
Lind, Anne-Li. "Biomarkers for Better Understanding of the Pathophysiology and Treatment of Chronic Pain : Investigations of Human Biofluids." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-326180.
Full textUppsala Berzelii Technology Centre for Neurodiagnostics
Nanna, W. L. Bryan. "Arterial fluid mechanics computations with the stabilized space-time fluid-structure interaction techniques." Thesis, 2007. http://hdl.handle.net/1911/20565.
Full textCragin, Timothy L. "Stabilized space-time fluid-structure interaction techniques with the continuum element." Thesis, 2007. http://hdl.handle.net/1911/20497.
Full textHaque, Sara Salim. "Applications of Nanoparticle Image Velocimetry in Nanofluids." 2011. http://trace.tennessee.edu/utk_gradthes/974.
Full textΜανόπουλος, Χρήστος. "Πειραματικός και θεωρητικός προσδιορισμός "περισταλτικών αντλιών αίματος"." Thesis, 1999. http://nemertes.lis.upatras.gr/jspui/handle/10889/3174.
Full textJoly, Florian. "Numerical Insights for AAA Growth Understanding and Predicting: Morphological and Hemodynamic Risk Assessment Features and Transient Coherent Structures Uncovering." Thèse, 2019. http://hdl.handle.net/1866/22597.
Full textShajahan, T. K. "Studies Of Spiral Turbulence And Its Control In Models Of Cardiac Tissue." Thesis, 2008. http://hdl.handle.net/2005/759.
Full textMengistu, Meron. "The effects of fluid shear stress on micro-mechanical properties and mechanotransduction events in endothelial cells." 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3314475.
Full text"Numerical studies of fluid-structure interactions in biomechanical systems." Tulane University, 2007.
Find full textacase@tulane.edu
(11205849), Patrick A. Giolando. "Mathematical and Computational Modeling in Biomedical Engineering." Thesis, 2021.
Find full textMathematical and computational modeling allow for the rationalization of complex phenomenon observed in our reality. Through the careful selection of assumptions, the intractable task of simulating reality can be reduced to the simulation of a practical system whose behavior can be replicated. The development of computational models allow for the full comprehension of the defined system, and the model itself can be used to evaluate the results of thousands of simulate experiments to aid in the rational design process.
Biomedical engineering is the application of engineering principles to the field of medicine and biology. This discipline is composed of numerous diverse subdisciplines that span from genetic engineering to biomechanics. Each of these subdisciplines is concerned with its own complex and seemingly chaotic systems, whose behavior is difficult to characterize. The development and application of computational modeling to rationalize these systems is often necessary in this field and will be the focus of this thesis.
This thesis is centered on the development and application of mathematical and computational modeling in three diverse systems in biomedical engineering. First, computational modeling is employed to investigate the behavior of key proteins in the post-synapse centered around learning and memory. Second, computational modeling is utilized to characterize the drug release rate from implantable drug delivery depots, and produce a tool to aid in the tailoring of the release rate. Finally, computational modeling is utilized to understand the motion of particles through an inertial focusing microfluidics chip and optimize the size selective capture efficiency.
Yum, Kyungsuk. "Interfacing nanomaterials with fluids and living biological systems /." 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3363123.
Full textSource: Dissertation Abstracts International, Volume: 70-06, Section: B, page: 3757. Adviser: Min-Feng Yu. Includes bibliographical references (leaves 93-110). Available on microfilm from Pro Quest Information and Learning.
Lightstone, Noam S. "Design of a Bioreactor to Mimic Hemodynamic Shear Stresses on Endothelial Cells in Microfluidic Systems." Thesis, 2014. http://hdl.handle.net/1807/65572.
Full textFurse, Alexander. "Development of a Low Cost Swing-phase Control Mechanism." Thesis, 2010. http://hdl.handle.net/1807/25587.
Full textXie, Xueying. "Modeling viscoelastic free surface and interfacial flows, with applications to the deformation of droplets and blood cells." Thesis, 2006. http://hdl.handle.net/1911/18995.
Full text