Relevant bibliographies by topics / Biomedical applications of FBGs

Academic literature on the topic 'Biomedical applications of FBGs'

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Published: 6 September 2023

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Journal articles on the topic "Biomedical applications of FBGs"

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Shekhar, Himanshu, Kuldeep Jajoria, Chandan K. Jha, and Arup L. Chakraborty. "Fiber Bragg grating technology for biomedical ultrasound applications." Journal of the Acoustical Society of America 152, no. 4 (October 2022): A226. http://dx.doi.org/10.1121/10.0016090.

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Fiber Bragg gratings (FBGs) are a class of optical sensors that have been used widely in non destructive testing and monitoring. These sensors are compact, robust, inexpensive and immune to electromagnetic interference. FBGs serve as wavelength selective mirrors that reflect light at the Bragg wavelength. An applied strain results in a shift in the Bragg wavelength, which can be used to detect physical parameters such as temperature and pressure. Recent work suggests that FBGs could have potential for measurements in the biomedical ultrasound frequency range. In this presentation, I will provide an overview of ongoing work in our group on employing FBGs for applications in therapeutic ultrasound. Specifically, I will discuss calibration of these sensors along with their use in passive cavitation detection. I will also present recent results on detecting nonlinear waveforms relevant to focused ultrasound along with temperature measurement for thermal therapy. We envisage that these sensors will be useful in laboratory research environments, and for specialized therapy applications in the clinical setting.
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Zhang, Wen, Lianqing Zhu, Mingli Dong, Xiaoping Lou, and Feng Liu. "A Temperature Fiber Sensor Based on Tapered Fiber Bragg Grating Fabricated by Femtosecond Laser." Applied Sciences 8, no. 12 (December 14, 2018): 2616. http://dx.doi.org/10.3390/app8122616.

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A temperature fiber sensor based on tapered fiber Bragg grating (tapered FBG) fabricated by femtosecond laser has been proposed and realized with good reproducibility. Firstly, the fiber taper with 25 μm diameter and 1000 μm length is fabricated by arc-discharge elongation using two standard single-mode fibers. Secondly, two first-order FBGs are fabricated in tapered and non-tapered fiber regions for comparison. Both FBGs are point-by-point direct-written by femtosecond laser, and the grating lengths are 1000 μm. Thirdly, a temperature experiment is performed using a heating chamber, and experimental results show that in the range of 30~350 °C, the temperature sensitivity of the tapered FBG has increased from 11.0 pm/°C to 12.3 pm/°C. The tapered FBG proposed here can be further configured for sensing other parameters in physical, chemical, and biomedical applications.
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De Tommasi, Francesca, Chiara Romano, Daniela Lo Presti, Carlo Massaroni, Massimiliano Carassiti, and Emiliano Schena. "FBG-Based Soft System for Assisted Epidural Anesthesia: Design Optimization and Clinical Assessment." Biosensors 12, no. 8 (August 16, 2022): 645. http://dx.doi.org/10.3390/bios12080645.

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Fiber Bragg grating sensors (FBGs) are considered a valid sensing solution for a variety of medical applications. The last decade witnessed the exploitation of these sensors in applications ranging from minimally invasive surgery to biomechanics and monitoring physiological parameters. Recently, preliminary studies investigated the potential impact of FBGs in the management of epidural procedures by detecting when the needle reaches the epidural space with the loss of resistance (LOR) technique. In this article, we propose a soft and flexible FBG-based system capable of detecting the LOR, we optimized the solution by considering different designs and materials, and we assessed the feasibility of the optimized soft sensor (SS) in clinical settings. The proposed SS addresses some of the open challenges in the use of a sensing solution during epidural punctures: it has high sensitivity, it is non-invasive, the sensing element does not need to be inserted within the needle, and the clinician can follow the standard clinical practice. Our analysis highlights how the material and the design impact the system response, and thus its performance in this scenario. We also demonstrated the system’s feasibility of detecting the LOR during epidural procedures.
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KOT, Marcin, Łukasz MAJOR, Roman MAJOR, Jurgen LACKNER, and Maureen PONTIE. "COATINGS WITH ADVANCED MICROSTRUCTURE FOR BIOMEDICAL APPLICATIONS." Tribologia 272, no. 2 (April 30, 2017): 77–83. http://dx.doi.org/10.5604/01.3001.0010.6301.

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The paper presents the effect of the complex architecture of Cr/CrN+a-C:H coatings on their mechanical and tribological properties. These advanced coatings were compared with CrN single coatings and Cr/CrN multilayers. All of them were deposited by the magnetron sputtering technique. The conducted tests allowed nanohardness, elasticity modulus, fracture toughness, and adhesion of coatings to steel substrates to be determined. Tribological tests were carried out under dry friction and in the presence of phosphate-buffered saline PBS and foetal bovine serum FBS. For all test conditions, the friction coefficient and the wear index of the produced coatings were determined. The lowest wear and the lowest coefficient of friction are exhibited by coatings with complex Cr/CrN+a-C:H architecture. Furthermore, they are also resistant to the highly corrosive PBS environment.
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Chaitin, Hersh, Michael L. Lu, Michael B. Wallace, and Yunqing Kang. "Development of a Decellularized Porcine Esophageal Matrix for Potential Applications in Cancer Modeling." Cells 10, no. 5 (April 29, 2021): 1055. http://dx.doi.org/10.3390/cells10051055.

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Many decellularized extracellular matrix-derived whole organs have been widely used in studies of tissue engineering and cancer models. However, decellularizing porcine esophagus to obtain decellularized esophageal matrix (DEM) for potential biomedical applications has not been widely investigated. In this study a modified decellularization protocol was employed to prepare a porcine esophageal DEM for the study of cancer cell growth. The cellular removal and retention of matrix components in the porcine DEM were fully characterized. The microstructure of the DEM was observed using scanning electronic microscopy. Human esophageal squamous cell carcinoma (ESCC) and human primary esophageal fibroblast cells (FBCs) were seeded in the DEM to observe their growth. Results show that the decellularization process did not cause significant loss of mechanical properties and that blood ducts and lymphatic vessels in the submucosa layer were also preserved. ESCC and FBCs grew on the DEM well and the matrix did not show any toxicity to cells. When FBS and ESCC were cocultured on the matrix, they secreted more periostin, a protein that supports cell adhesion on matrix. This study shows that the modified decellularization protocol can effectively remove the cell materials and maintain the microstructure of the porcine esophageal matrix, which has the potential application of studying cell growth and migration for esophageal cancer models.
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Binetti, Leonardo, Alicja Stankiewicz, and Lourdes S. M. Alwis. "Graphene-Oxide and Hydrogel Coated FBG-Based pH Sensor for Biomedical Applications." Proceedings 2, no. 13 (December 3, 2018): 789. http://dx.doi.org/10.3390/proceedings2130789.

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A hydrogel coated fibre grating-based pH sensor for biomedical applications has been realised, where Graphene Oxide (GO) had been used to enhance the bonding between the coating and the fibre. Two methods of deposition of GO were analysed i.e., evaporation and co-electroplating. The paper concludes that the system of GO evaporated on the fibre + the hydrogel has a sensitivity much higher, (6.1 ± 0.5) pm/pH, than the system of Cu and GO co-electroplated + the hydrogel, (1.9 ± 0.1) pm/pH, for a pH range between 2 to 10. The other conclusion is that the first system has a less coating bonding energy with the optical fibre whereas the second system has a stronger bonding energy, with better durability.
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Kanellos, George T., George Papaioannou, Dimitris Tsiokos, Christos Mitrogiannis, George Nianios, and Nikos Pleros. "Two dimensional polymer-embedded quasi-distributed FBG pressure sensor for biomedical applications." Optics Express 18, no. 1 (December 22, 2009): 179. http://dx.doi.org/10.1364/oe.18.000179.

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Safoine, Meryem, Alexandra Côté, Romane Leloup, Cindy Jean Hayward, Marc-André Plourde Campagna, Jean Ruel, and Julie Fradette. "Engineering naturally-derived human connective tissues for clinical applications using a serum-free production system." Biomedical Materials 17, no. 5 (August 11, 2022): 055011. http://dx.doi.org/10.1088/1748-605x/ac84b9.

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Abstract The increasing need for tissue substitutes in reconstructive surgery spurs the development of engineering methods suited for clinical applications. Cell culture and tissue production traditionally require the use of fetal bovine serum (FBS) which is associated with various complications especially from a translational perspective. Using the self-assembly approach of tissue engineering, we hypothesized that all important parameters of tissue reconstruction can be maintained in a production system devoid of FBS from cell extraction to tissue reconstruction. We studied two commercially available serum-free medium (SFM) and xenogen-free serum-free medium (XSFM) for their impact on tissue reconstruction using human adipose-derived stem/stromal cells (ASCs) in comparison to serum-containing medium. Both media allowed higher ASC proliferation rates in primary cultures over five passages compared with 10% FBS supplemented medium while maintaining high expression of mesenchymal cell markers. For both media, we evaluated extracellular matrix production and deposition necessary to engineer manipulatable tissues using the self-assembly approach. Tissues produced in SFM exhibited a significantly increased thickness (up to 6.8-fold) compared with XSFM and FBS-containing medium. A detailed characterization of tissues produced under SFM conditions showed a substantial 50% reduction of production time without compromising key tissue features such as thickness, mechanical resistance and pro-angiogenic secretory capacities (plasminogen activator inhibitor 1, hepatocyte growth factor, vascular endothelial growth factor, angiopoietin-1) when compared to tissues produced in the control FBS-containing medium. Furthermore, we compared ASCs to the frequently used human dermal fibroblasts (DFs) in the SFM culture system. ASC-derived tissues displayed a 2.4-fold increased thickness compared to their DFs counterparts. In summary, we developed all-natural human substitutes using a production system compatible with clinical requirements. Under culture conditions devoid of bovine serum, the resulting engineered tissues displayed similar and even superior structural and functional properties over the classic FBS-containing culture conditions with a considerable 50% shortening of production time.
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Masud, Usman, Muhammad Rizwan Amirzada, Hassan Elahi, Faraz Akram, Ahmed Zeeshan, Yousuf Khan, Muhammad Khurram Ehsan, et al. "Design of Two-Mode Spectroscopic Sensor for Biomedical Applications: Analysis and Measurement of Relative Intensity Noise through Control Mechanism." Applied Sciences 12, no. 4 (February 11, 2022): 1856. http://dx.doi.org/10.3390/app12041856.

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The design of an intracavity spectroscopy based two-mode biomedical sensor involves a thorough investigation of the system. For this purpose, the individual components that are present in the system must be examined. This work describes the principle of two very important gadgets, namely the Fibre Bragg Grating (FBG), and the tunable coupler. We adhere to a Petri network scheme to model and analyze the performance of the FBG, and the results mirror strikingly low difference in the values of Bragg Wavelength during its ascending and descending operational principle, thereby maintaining the accuracy of the sensor’s results. Next, a pseudocode is developed and implemented for the investigation of the optical coupler in LabView. The values of its maximum output power are determined, and the coupling ratio for various values of controlling voltage is determined at three different wavelengths. The hysteresis results mirror an extremely low difference between the forward and reverse values in the results. Both the results of the FBG and the coupler are thereby extremely reliable to use them in the laser system, as evident from the respective intensity noise outcomes, as well as the experimentation on substances of interest (Dichloro Methane and Propofol).
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He, Yanlin, Xu Zhang, Lianqing Zhu, Guangkai Sun, Xiaoping Lou, and Mingli Dong. "Optical Fiber Sensor Performance Evaluation in Soft Polyimide Film with Different Thickness Ratios." Sensors 19, no. 4 (February 15, 2019): 790. http://dx.doi.org/10.3390/s19040790.

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To meet the application requirements of curvature measurement for soft biomedical robotics and flexible morphing wings of aircraft, the optical fiber Bragg grating (FBG) shape sensor for soft robots and flexible morphing wing was implemented. This optical FBG is embedded in polyimide film and then fixed in the body of a soft robot and morphing wing. However, a lack of analysis on the embedded depth of FBG sensors in polyimide film and its sensitivity greatly limits their application potential. Herein, the relationship between the embedded depth of the FBG sensor in polyimide film and its sensitivity and stability are investigated. The sensing principle and structural design of the FBG sensor embedded in polyimide film are introduced; the bending curvatures of the FBG sensor and its wavelength shift in polyimide film are studied; and the relationship between the sensitivity, stability, and embedded depth of these sensors are verified experimentally. The results showed that wavelength shift and curvature have a linear relationship. With the sensor’s curvature ranging from 0 m−1 to 30 m−1, their maximum sensitivity is 50.65 pm/m−1, and their minimum sensitivity is 1.96 pm/m−1. The designed FBG sensor embedded in polyimide films shows good consistency in repeated experiments for soft actuator and morphing wing measurement; the FBG sensing method therefore has potential for real applications in shape monitoring in the fields of soft robotics and the flexible morphing wings of aircraft.
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Dissertations / Theses on the topic "Biomedical applications of FBGs"

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Child, Hannah. "Nanoparticles for biomedical applications." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3583/.

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Modern day medicine is on the brink of a new age of therapy, which aims to harness the natural power of molecular biology for disease treatment. This therapy could include replacement of dysfunctional genes that cause disorders such as cystic fibrosis (Lommatzsch and Aris, 2009), or silencing the overexpression of genes that cause disorders such as cancer (Pelengaris and Khan, 2003). In both examples, the treatment of these genetic diseases lies in the delivery of synthetic nucleic acids into diseased cells, the former being called gene replacement therapy (Dobson, 2006a), and the latter being called RNA interference (RNAi) therapy (Whitehead et al., 2009). While these techniques have long been in use as genetic research tools for gene transfection or silencing in vitro, their translation for use in clinical disease treatment has yet to be achieved. The main problem facing the development of these novel therapies is the specific delivery of nucleic acids into diseased cells within the body. It is hoped that nanoparticles (NPs) can be used to overcome this problem, by acting as vehicles to transport nucleic acids through the body for specific delivery into diseased cells. This feat can be aided by the attachment of additional functional molecules such as cell penetrating peptides (CPPs), targeting peptides, additional drug types and molecules for imaging during treatment. Many different NP design strategies are currently under development. It is essential for new designs to be extensively tested for toxicity and efficiency in human cells before they can be successfully released into the clinic. As part of this effort, this PhD project has investigated two different NP design strategies for drug delivery: 1) the use of a magnetic field (MF) and a CPP to increase the delivery of iron oxide magnetic NPs (mNPs) to cells grown in tissueequivalent 3D collagen gels, and 2) gold NPs (AuNPs) for the delivery of siRNA to silence the c-myc oncogene for cancer treatment. In the first investigation, a MF and the CPP penetratin were found to increase mNP delivery to cells grown in 3D. In the second investigation, AuNPs were assessed in a range of different cell types (grown in 2D) for their performance in 4 main areas; cellular toxicity, cellular uptake, c-myc knockdown and effect on the cell cycle.
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Hughes-Brittain, Nanayaa Freda. "Photoembossing for biomedical applications." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8294.

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Surface topography is known to be important in biomedical applications such as scaffolds for tissue regeneration and has been shown to affect wettability and cell behaviour. Traditionally, topographical effects such as surface texturing have been generated using methods such as photolithography, soft lithography, thermal embossing, and laser/electron beam techniques. This thesis introduces a relatively new technique known as photoembossing to create surface texturing for biomedical applications. Photoembossing is used to produce surface texturing on polymer surfaces by patterned ultraviolet (UV) exposure of a photopolymer blend without an etching step or an expensive mould. After a short general introduction and a literature review, the first experimental chapters describe surface patterning of poly(methyl methacrylate) (PMMA) photopolymer substrates by photoembossing. PMMA is blended with an acrylate monomer and photoinitiator by dissolution in a volatile solvent and processed into films by wire bar coating, and fibres are produced by electrospinning. Surface texture is achieved on both films and fibres by photoembossing. Endothelial cell culture shows that the substrates are biocompatible and cells readily adhere to the surface. In tissue regeneration applications, scaffold degradation is often important to allow tissue in-growth. Thus, in subsequent studies polylactide-co-glycolide (PLGA) is used as a polymer binder. PLGA blended with a triacrylate monomer showed partial degradation after 10 weeks, with a cross-linked acrylate network remaining. Endothelial cell adhesion was even better on the PLGA photopolymer substrates compared to PMMA. Furthermore, surface texture improved cell adhesion and proliferation on the PLGA photopolymer. To obtain completely degradable substrates, thiol monomer was used in addition to the acrylate to produce ester bonds after the thiol-ene reaction, which is cleavable by hydrolysis. Accelerated degradation in sodium hydroxide (NaOH) showed complete degradation of this photopolymer system. The degradation rate of the photopolymer could be tuned by the molecular weight of the acrylate monomer, with low molecular weight monomers degrading more slowly than high molecular weight species. Furthermore, the height of the surface relief structures could be enhanced by using low-molecular-weight acrylate monomers. Endothelial cell culture revealed biocompatibility of the blend and cells were able to adhere after 24 hours of seeding. This thesis demonstrates that photoembossing is a viable technique in producing surface texture for tissue engineering applications. This surface texture can be achieved on both biocompatible and biodegradable photopolymer films and fibres.
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Abbas, Aiman Omar Mahmoud. "Chitosan for biomedical applications." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/771.

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Chitosan, a copolymer of glucosamine and N-acetyl glucosamine, is a polycationic, biocompatible and biodegradable polymer. In addition, chitosan has different functional groups that can be modified with a wide array of ligands. Because of its unique physicochemical properties, chitosan has great potential in a range of biomedical applications, including tissue engineering, non-viral gene delivery and enzyme immobilization. In our work, the primary amine groups of chitosan were utilized for chitosan modification through biotinylation using N-hydroxysuccinimide chemistry. This was followed by the addition of avidin which strongly binds to biotin. Biotinylated ligands such as polyethylene glycol (PEG) and RGD peptide sequence, or biotinylated enzymes such as trypsin, were then added to modify the surface properties of the chitosan for a variety of purposes. Modified chitosans were formulated into nano-sized particles or cast into films. Different factors affecting fabrication of chitosan particles, such as the pH of the preparation, the inclusion of polyanions, the charge ratios and the degree of deacetylation and the molecular weight of chitosan were studied. Similarly, parameters affecting the fabrication of chitosan films, such as cross-linking, were investigated for potential applications in tissue engineering and enzyme immobilization. It was found that the inclusion of dextran sulfate resulted in optimum interaction between chitosan and DNA, as shown by the high stability of these nanoparticles and their high in vitro transfection efficiencies in HEK293 cells. When applying these formulations as DNA vaccines in vivo, chitosan nanoparticles loaded with the ovalbumin antigen and the plasmid DNA encoding the same antigen resulted in the highest antibody response in C57BL/6 mice. Furthermore, engineering of the surface of chitosan nanoparticles was done by utilizing the avidin-biotin interaction for attaching PEG and RGD. The modified formulations were tested for their in vitro gene delivery properties and it was found that these ligands improved gene transfection efficiencies significantly. Chitosan nanoparticles were optimized further for enzyme immobilization purposes using sodium sulfate and glutaraldehyde as physical and chemical cross-linking agents, respectively. These particles and chitosan films were used for immobilizing trypsin utilizing several techniques. Enzyme immobilization via avidin-biotin interaction resulted in high immobilization efficiency and high enzymatic activity in different reaction conditions. Additionally, the immobilized trypsin systems were stable and amenable to be regenerated for multiple uses. Finally, glutaraldehyde cross-linked chitosan films were modified with PEG and RGD for their cell repellant and cell adhesion properties, respectively, using avidin-biotin interaction. This method was again effective in engineering chitosan surfaces for modulating cell adhesion and proliferation. In conclusion, using avidin-biotin technique to modify biotinylated chitosan surfaces is a facile method to attach a wide variety of ligands in mild reaction conditions, while preserving the functionality of these ligands.
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Zomer, Volpato Fabio. "Composites for Biomedical Applications." Doctoral thesis, Università degli studi di Trento, 2010. https://hdl.handle.net/11572/368680.

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In the past few years, significant progress in the study of scaffolds for cells grow has taken place. This research has led to the development of a wide variety of metallic, polymeric, ceramic and composite biomaterials. This thesis describes the development of a novel composite system with tunable morphological and mechanical properties, ease of production and capability to guide the biological response. The composite system was composed by polyamide 6 (PA6) and carboxyl-functionalized multi-walled carbon nanotubes (MWCNT), which were used as reinforcement agents in the polymer matrix. Electrospinning was used as the fabrication technique for the production of anisotropic networks. Physical and biological properties of the nets were evaluated focusing on the effect of the filler addition. It was observed that the production technique induced the alignment of MWCNT within the nanofiber axis and the formation of a roughness on the fiber's surface. The biological properties of MG63 and MRC5 cell lines were enhanced if compared with the neat PA6 networks due to surface modification caused by the filler addition.
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Zomer, Volpato Fabio. "Composites for Biomedical Applications." Doctoral thesis, University of Trento, 2010. http://eprints-phd.biblio.unitn.it/334/1/PhD_Thesis_Zomer_Volpato%2C_Fabio.pdf.

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In the past few years, significant progress in the study of scaffolds for cells grow has taken place. This research has led to the development of a wide variety of metallic, polymeric, ceramic and composite biomaterials. This thesis describes the development of a novel composite system with tunable morphological and mechanical properties, ease of production and capability to guide the biological response. The composite system was composed by polyamide 6 (PA6) and carboxyl-functionalized multi-walled carbon nanotubes (MWCNT), which were used as reinforcement agents in the polymer matrix. Electrospinning was used as the fabrication technique for the production of anisotropic networks. Physical and biological properties of the nets were evaluated focusing on the effect of the filler addition. It was observed that the production technique induced the alignment of MWCNT within the nanofiber axis and the formation of a roughness on the fiber's surface. The biological properties of MG63 and MRC5 cell lines were enhanced if compared with the neat PA6 networks due to surface modification caused by the filler addition.
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Chin, Suk Fun. "Superparamagnetic nanoparticles for biomedical applications." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0128.

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[Truncated abstract] In the past decade, the synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) has received considerable attention due to their potential applications in biomedical fields. However, success in size and shape control of the SPIONs has been mostly achieved through organic routes using large quantities of toxic or/and expensive precursors in organic reaction medium at high reaction temperature. This has limited the biomedical applications of SPIONs and therefore, development of a synthetic method under aqueous condition that is reproducible, scalable, environmentally benign, and economically feasible for industrial production is of paramount importance in order to fully realise their practical applications. Spinning Disc Processing (SDP) has been used to synthesise superparamagnetic magnetite (Fe3O4) nanoparticles at room temperature via a modified chemical precipitation method under continuous flow condition and offer a potential alternative to be applied to SPIONs production. SDP has extremely rapid mixing under plug flow conditions, effective heat and mass transfer, allowing high throughput with low wastage solvent efficiency. The synthesis process involves passing ammonia gas over a thin aqueous film of Fe2+/3+ which is introduced through a jet feed close to the centre of a rapidly rotating disc (500-2500 rpm). Synthetic parameters such as precursor concentrations, temperature, flow rate, disc speed, and surface texture influence the particle sizes. ... Magnetic silica microspheres are receiving great attention for possible applications in magnetic targeting drug delivery, bioseparation and enzyme isolation. However, the current available methods for preparation suffer from the setback of low loading of Fe3O4 nanoparticles in the silica microsphere, which result in low magnetic moment, thereby limiting their practical applications. Therefore it is of considerable importance to develop new alternative synthetic methods for fabricating magnetic silica microspheres with high magnetic nanoparticles loading. Superparamagentic Fe3O4 nanoparticles (8-10 nm diameter) and curcumin have been encapsulated in mesoporous silica in a simple multiplestep self assembly approach process with high Fe3O4 nanoparticles loading (37%). The synthesis involves loading of curcumin in the Cetyltrimethylammonium bromide (CTAB) micellar rod in the presence of superparamagnetic Fe3O4 nanoparticles via a parallel synergistic approach. The synthesised magnetic mesoporous silica composite material is stable, superparamagnetic with high saturation magnetisation before and after curcumin leaching experiment. Under physiological pH in phosphate buffer, the curcumin is slowly released over several days. These magnetic mesoporous silica are expected to have great potential as targeted drug delivery systems.
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Zurutuza, Amaia. "Novel microgels for biomedical applications." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248836.

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Cantini, Eleonora. "Switchable surfaces for biomedical applications." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8040/.

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Switchable oligopeptides, able to expose of conceal biomolecules on a surface, upon the application of an electrical potential, represent a versatile tool for the development of novel devices, presenting potential biomedical applications. Recently, several studies have demonstrated the applicability of smart devices for the control of protein binding and cellular response. In this work; a detailed analysis of the steric requirements necessary to develop a mixed oligopeptide Self-Assembled Monolayer (SAM) presenting an optimum switching ability will be described. The influence of both the SAM components surface ratio and the switching unit length on the mixed SAMs switching performance will be investigated. The findings of this investigation will be used to develop, for the first time, a platform, based on electrically switchable oligopeptides, able to control the interaction between an antigen and its relative antibody. The influence of the biological medium on the oligopeptide switching ability will also be investigated. Finally, an orthogonal functionalisation strategy, will be investigated in detail, together with a new platform able to promote human sperm cells adhesion. The results of this research thesis will also represent the first building blocks towards the development of glass-gold rnicropattemed surfaces able to control the calcium signalling in human sperm cells, presenting potential applications in the improvement of in-vitro fertilisation (NF) treatments success rates.
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Christiansen, Michael G. (Michael Gary). "Magnetothermal multiplexing for biomedical applications." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111248.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2017.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 170-176).
Research on biomedical applications of magnetic nanoparticles (MNPs) has increasingly sought to demonstrate noninvasive actuation of cellular processes and material responses using heat dissipated in the presence of an alternating magnetic field (AMF). By modeling the dependence of hysteresis losses on AMF amplitude and constraining AMF conditions to be physiologically suitable, it can be shown that MNPs exhibit uniquely optimal driving conditions that depend on controllable material properties such as magnetic anisotropy, magnetization, and particle volume. "Magnetothermal multiplexing," which relies on selecting materials with substantially distinct optimal AMF conditions, enables the selective heating of different kinds of collocated MNPs by applying different AMF parameters. This effect has the potential to extend the functionality of a variety of emerging techniques with mechanisms that rely on bulk or nanoscale heating of MNPs. Experimental investigations on methods for actuating deep brain stimulation, drug release, and shape memory polymer response are summarized, with discussion of the feasibility and utility of applying magnetothermal multiplexing to similar systems. The possibility of selective heating is motivated by a discussion of various models for heat dissipation by MNPs in AMFs, and then corroborated with experimental calorimetry measurements. A heuristic method for identifying materials and AMF conditions suitable for multiplexing is demonstrated on a set of iron oxide nanoparticles doped with various concentrations of cobalt. Design principles for producing AMFs with high amplitude and ranging in frequency from 15kHz to 2.5MHz are explained in detail, accompanied by a discussion of the outlook for scalability to clinically relevant dimensions. The thesis concludes with a discussion of the state of the field and the broader lessons that can be drawn from the work it describes.
by Michael G. Christiansen.
Ph. D.
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Degani, Ismail. "Biomedical applications of holographic microscopy." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/118494.

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Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, System Design and Management Program, 2018.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 77-79).
Identifying patients with aggressive cancers is a major healthcare challenge in resource-limited settings such as sub-Saharan Africa. Holographic imaging techniques have been shown to perform diagnostic screening at low cost in order to meet this clinical need, however the computational and logistical challenges involved in deploying such systems are manifold. This thesis aims to make two specific contributions to the field of point-of-care diagnostics. First, it documents the design and construction of low-cost holographic imaging hardware which can serve as a template for future research and development. Second, it presents a novel deep-learning architecture that can potentially lower the computational burden of digital holography by replacing existing image reconstruction methods. We demonstrate the effectiveness of the algorithm by reconstructing biological samples and quantifying their structural similarity relative to spatial deconvolution methods. The approaches explored in this work could enable a standalone holographic platform that is capable of efficiently performing diagnostic screening at the point of care.
by Ismail Degani.
S.M. in Engineering and Management
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Books on the topic "Biomedical applications of FBGs"

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Djokić, Stojan S., ed. Biomedical Applications. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-3125-1.

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service), SpringerLink (Online, ed. Biomedical Applications. Boston, MA: Springer US, 2012.

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S, Abd-El-Aziz Alaa, ed. Biomedical applications. Hoboken, N.J: Wiley-Interscience, 2004.

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Vermette, Patrick. Biomedical applications of polyurethanes. Georgetown, Tex: Landes Bioscience, 2001.

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Klajnert, Barbara, Ling Peng, and Valentin Cena, eds. Dendrimers in Biomedical Applications. Cambridge: Royal Society of Chemistry, 2013. http://dx.doi.org/10.1039/9781849737296.

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Andrianov, Alexander K. Polyphosphazenes for biomedical applications. Hoboken, N.J: Wiley, 2009.

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Gopi, Sreerag, Preetha Balakrishnan, and Nabisab Mujawar Mubarak, eds. Nanotechnology for Biomedical Applications. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7483-9.

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Labhasetwar, Vinod, and Diandra L. Leslie-Pelecky, eds. Biomedical Applications of Nanotechnology. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470152928.

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Ježek, Jan, Jan Hlaváček, and Jaroslav Šebestík. Biomedical Applications of Acridines. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63953-6.

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Rai, Mahendra, Avinash P. Ingle, and Serenella Medici, eds. Biomedical Applications of Metals. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-74814-6.

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Book chapters on the topic "Biomedical applications of FBGs"

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Bakshi, Mandeep Singh, and Gurinder Kaur Ahluwalia. "Biomedical Applications." In Applications of Chalcogenides: S, Se, and Te, 263–83. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41190-3_7.

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Hastings, G. W. "Biomedical Applications." In Carbon Fibres and Their Composites, 261–71. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70725-4_17.

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Schultz, Jerome S. "Biomedical Applications." In Synthetic Membranes: Science, Engineering and Applications, 647–65. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4712-2_22.

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Popot, Jean-Luc. "Biomedical Applications." In Membrane Proteins in Aqueous Solutions, 659–82. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-73148-3_15.

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Méndez, Vicenç, Sergei Fedotov, and Werner Horsthemke. "Biomedical Applications." In Reaction–Transport Systems, 245–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-11443-4_8.

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Roppolo, Ignazio, Annalisa Chiappone, Alessandro Chiadò, Gianluca Palmara, and Francesca Frascella. "Biomedical Applications." In High Resolution Manufacturing from 2D to 3D/4D Printing, 155–89. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-13779-2_7.

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Baylón, Karen, Elisabetta Ceretti, Claudio Giardini, and Maria Luisa Garcia-Romeu. "Forming Applications." In Biomedical Devices, 49–77. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119267034.ch3.

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Özel, Tuğrul, Elisabetta Ceretti, Thanongsak Thepsonthi, and Aldo Attanasio. "Machining Applications." In Biomedical Devices, 99–120. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119267034.ch5.

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Yadav, Shakti Kumar, Sompal Singh, and Ruchika Gupta. "Applications of Statistics." In Biomedical Statistics, 3–7. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-32-9294-9_1.

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Özel, Tuğrul, Joaquim De Ciurana Gay, Daniel Teixidor Ezpeleta, and Luis Criales. "Laser Processing Applications." In Biomedical Devices, 79–98. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119267034.ch4.

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Conference papers on the topic "Biomedical applications of FBGs"

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Korganbayev, Sanzhar, Yerzhan Orazayev, Sultan Sovetov, Ali Bazyl, Daniele Tosi, Emiliano Schena, Carlo Massaroni, Riccardo Gassino, Alberto Vallan, and Guido Perrone. "Thermal gradient estimation with fiber-optic chirped FBG sensors: Experiments in biomedical applications." In 2017 IEEE SENSORS. IEEE, 2017. http://dx.doi.org/10.1109/icsens.2017.8234119.

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Kanellos, George T., Dimitris Tsiokos, Nikos Pleros, Paul Childs, and Stavros Pissadakis. "Enhanced durability FBG-based sensor pads for biomedical applications as human-machine interface surfaces." In 2011 International Workshop on Biophotonics. IEEE, 2011. http://dx.doi.org/10.1109/iwbp.2011.5954848.

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Goebel, Thorsten A., Maximilian Weissflog, Ria G. Krämer, Maximilian Heck, Daniel Richter, and Stefan Nolte. "Tuning multichannel filters based on FBG in multicore fibers." In Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XIX, edited by Peter R. Herman, Michel Meunier, and Roberto Osellame. SPIE, 2019. http://dx.doi.org/10.1117/12.2513850.

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Yang, Jianjun, Jiansheng Liu, Baorui Yu, Minghui Ma, Jingyuan Hu, Hongfeng Shao, Xin Zhao, and Zheng Zheng. "Shape sensing based on dual-comb demodulation of a fiber Bragg grating sensing array." In Conference on Lasers and Electro-Optics/Pacific Rim. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleopr.2022.ctha6d_01.

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Abstract:
A system for realizing shape sensing based on the single-cavity dual-comb spectroscopy technology and a dense all-identical fiber Bragg grating (FBG) sensor array is demonstrated. High spatial resolution and small measurement error can be realized with the proposed system, based on two-dimensional shaping sensing experiments. This scheme could find applications in real-time monitoring of flexible structures and facilitate the development of novel robotics and biomedical devices.
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Saccomandi, P., M. A. Caponero, A. Polimadei, M. Francomano, D. Formica, D. Accoto, E. Tamilia, F. Taffoni, G. Di Pino, and E. Schena. "An MR-compatible force sensor based on FBG technology for biomedical application." In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2014. http://dx.doi.org/10.1109/embc.2014.6944929.

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Faustov, A., P. Saffari, C. Koutsides, A. Gusarov, M. Wuilpart, P. Megret, K. Kalli, and L. Zhang. "Highly radiation sensitive Type IA FBGs for dosimetry applications." In 2011 12th European Conference on Radiation and Its Effects on Components and Systems (RADECS). IEEE, 2011. http://dx.doi.org/10.1109/radecs.2011.6131460.

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Laffont, Guillaume. "Challenging Applications for Regenerated FBGs Focus on Temperature Sensing." In Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides. Washington, D.C.: OSA, 2014. http://dx.doi.org/10.1364/bgpp.2014.bm2d.1.

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Yang, Shiquan, Zhaohui Li, Shuzhong Yuan, Xiaoyi Dong, Guiyun Kai, and Qida Zhao. "Dual-wavelength actively mode-locked erbium-doped fiber laser using FBGs." In High-Power Lasers and Applications, edited by L. N. Durvasula. SPIE, 2003. http://dx.doi.org/10.1117/12.478265.

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Gouvêa, Paula M. P. "Applications of FBGs in Oil & Gas and in Aeronautics." In Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/bgpp.2016.bm5b.1.

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Czaplińska, Katarzyna, Wiktoria Kondrusik, Piotr Araszkiewicz, and Konrad Markowski. "Superstructure FBGs induction through applying of the pressing force." In Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2019, edited by Ryszard S. Romaniuk and Maciej Linczuk. SPIE, 2019. http://dx.doi.org/10.1117/12.2538122.

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Reports on the topic "Biomedical applications of FBGs"

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Gao, Jun. Biomedical Applications of Microfluidic Technology. Office of Scientific and Technical Information (OSTI), March 2014. http://dx.doi.org/10.2172/1126675.

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Zimmerman, J. BMDO Technologies for Biomedical Applications. Fort Belvoir, VA: Defense Technical Information Center, December 1997. http://dx.doi.org/10.21236/ada338549.

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Kuehl, Michael, Susan Marie Brozik, David Michael Rogers, Susan L. Rempe, Vinay V. Abhyankar, Anson V. Hatch, Shawn M. Dirk, et al. Biotechnology development for biomedical applications. Office of Scientific and Technical Information (OSTI), November 2010. http://dx.doi.org/10.2172/1011213.

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Chait, Richard, and Julius Chang. Roundtable on Biomedical Engineering Materials and Applications. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada396606.

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Felberg, Lisa E. Computational simulations and methods for biomedical applications. Office of Scientific and Technical Information (OSTI), July 2017. http://dx.doi.org/10.2172/1488415.

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Chait, Richard, Teri Thorowgood, and Toni Marechaux. Roundtable on Biomedical Engineering Materials and Applications. Fort Belvoir, VA: Defense Technical Information Center, September 2002. http://dx.doi.org/10.21236/ada407761.

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Radparvar, M. Imaging systems for biomedical applications. Final report. Office of Scientific and Technical Information (OSTI), June 1995. http://dx.doi.org/10.2172/192410.

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Chait, Richard. Roundtable on Biomedical Engineering Materials and Applications. Fort Belvoir, VA: Defense Technical Information Center, September 2000. http://dx.doi.org/10.21236/ada391253.

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Peer, Akshit. Periodically patterned structures for nanoplasmonic and biomedical applications. Office of Scientific and Technical Information (OSTI), August 2017. http://dx.doi.org/10.2172/1505186.

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Sun, Xiaoxing. Mesoporous silica nanoparticles for biomedical and catalytical applications. Office of Scientific and Technical Information (OSTI), January 2011. http://dx.doi.org/10.2172/1029607.

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