Academic literature on the topic 'Biomatériaux complexes'
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Journal articles on the topic "Biomatériaux complexes":
Catros, Sylvain, Mathilde Fénelon, Hugo De Oliveira, Ghannaa Shayya, Joanna Babilotte, Olivier Chassande, and Jean-Christophe Fricain. "Impression 3D et bioimpression pour la régénération osseuse en chirurgie orale." médecine/sciences 40, no. 1 (January 2024): 92–97. http://dx.doi.org/10.1051/medsci/2023202.
Dissertations / Theses on the topic "Biomatériaux complexes":
Aloui, Eya. "Formulation de biomatériaux innovants à base de complexes biomacromoléculaires." Thesis, Strasbourg, 2020. http://www.theses.fr/2020STRAE012.
A new era in the design of biomaterials should emerge to deal simultaneously with issues related to toxicity of degradation products, infections and controlled release. Albumin-based materials are arousing growing interest due to their biocompatibility, biodegradability, biofunctionality and manufacturability. In the present study, a new class of materials based exclusively on albumin is designed. These materials are obtained by a salt-assisted compaction, where albumin solutions are mixed with salts and evaporated at 37 °C. After salt removal through washing, stable and water-insoluble solid albumin materials are produced. These materials present many advantages such as stability, good mechanical properties, reduced cost and ease of production and manufacture. Furthermore, biological evaluation shows that they are not cytotoxic, do not induce inflammation and allow the adhesion and proliferation of epithelial cells without additional surface functionalization. In addition, porous albumin sponges are easily produced using salt-assisted compaction. Therefore, these new materials are promising candidates for the development of biodegradable implantable devices and scaffolds for tissue engineering
Tirado, Viloria Patricia Carolina. "Nouveaux biomatériaux saloplastiques basés sur des complexes de polyélectrolytes ultracentrifugés." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00788462.
Ciobanu, Bogdan Constantin. "De nouveaux biomatériaux polymères complexes pour la modélisation de la cinétique de libération de médicaments." Thesis, Pau, 2013. http://www.theses.fr/2013PAUU3014/document.
The main objective of the PhD thesis entitled “Complex polymeric biomaterials for modeling the drug release kinetics” was to bring contributions in modeling the release kinetics of active ingredients from polymer-drug systems, attempting to reduce the "burst effect"' and increase the release time. The basic idea of the thesis was, in a first stage, the encapsulation of the drug in liposomes -lipid vesicles capable of drug transport- and their subsequent inclusion in polymeric hydrogels in the rationale of creating two "barriers" in drug release process. First, obtained hydrogels are based on chitosan/gelatin and chitosan/poly(vinyl alcohol) partly covalently crosslinked with glutaraldehyde and dominantly ionically with anion sulfate or tripolyphosphate. A second category is based on chitosan hydrogels, alone or in combination with poly(vinyl alcohol), crosslinked with tannic acid through numerous hydrogen bonds. Hydrogels were characterized structurally, morphologically, in terms of the behavior in aqueous media and thermal stability, the qualities of biomaterial (hemocompatibility and cytotoxicity), the ability to include and release a model compound (calcein) free or encapsulated in liposomes. Dependence of properties (swelling, release of soluble compounds included) on the preparation process parameters (amount of crosslinker, polymers ratio used, chitosan molecular weight) is established. Performing calcein release kinetic studies (calcein included directly in hydrogels or encapsulated in liposomes subsequently dispersed in hydrogels) proves the correctness of the starting hypothesis: whatever type of crosslinking applied for the preparation of hydrogels, the release of calcein from complex systems (hydrogel-liposomes-calcein) is much delayed without manifesting practically "burst effect". The paper concludes with a chapter with modeling the release kinetics from the studied systems and with the Conclusions and Perspectives. Given the potential application of such hydrogels in the form of films for treating skin conditions, preliminary results of levofloxacin release from a transdermal system that simulates human dermis are shown
Hardy, Alexandre. "Biomatériaux fonctionnels à base de complexes de polyélectrolytes compactés de type chitosan/alginate : conception, caractérisation et premières évaluations biologiques." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF024/document.
Nowadays, many chronic diseases, such as cancer or osteoarthritis, still need new modalities of treatment. Natural biomaterials able to convey active substances represent a solution to this problematic. Lately, several research works have been conducted on a new type of biomaterial named Compact Polyelectrolyte Complexes (CoPEC). As part of this thesis, CoPEC have been prepared from two biosourced polyelectrolytes, chitosan and alginate, functionalized with β-cyclodextrin (βCD). Through an in vitro inflammation model, the non-cytotoxic βCD-chitosan/alginate CoPEC has displayed intrinsic anti-inflammatory properties. Moreover, this CoPEC has demonstrated a capacity to host and release piroxicam and prednisolone, two model hydrophobic active substances. Finally, a strategy to include hydrophilic active substances into the material has been implemented.Thus, the newly CoPEC is promising because it can exhibit an intrinsic anti-inflammatory effect as well as other therapeutic effects through the inclusion of active substances into the cyclodextrins
Lalevée, Gautier. "Complexes polyélectrolytes d'acide hyaluronique et de chitosane pour des applications biomédicales." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1075.
This work is devoted to the elaboration of polyelectrolyte complexes systems combining two oppositely-charged polyelectrolytes and to the study of their potential application as - injectable dermal fillers. Hyaluronic acid as polyanion (carboxylic groups -COO as negative charges) was complexed with the only naturally-occuring polycation named + chitosan (amine groups -NH3 as positive charges). The factors impacting the formation of hyaluronic acid - chitosan complexes and their physico-chemical properties were investigated. We used a new technique of complexation developed in the laboratory through the desalting of highly salted mixtures, and systematically investigated the impact of pH in the range 2.5 - 6.5, corresponding to the complexation domain of hyaluronic acid and chitosan. This process allowed the progressive elimination of the salts and the slow restoration of the attractive electrostatic interactions resp onsible for the self-assembly of the two polyelectrolytes. Various physical forms were obtained: macroscopic aggregates, soluble complexes, colloidal suspensions or hydrogels. During this work, we observed for the first time the formation of hyaluronic acid-chitosan hydrogels exhibiting a very unusual hyper-stretchability, only at acidic pH. Therefore, an alternate approach consisted in taking advantage of the chitosan ability to gel in alkaline medium. By using a similar process, we were then able to form physically-crosslinked hyaluronic acid-chitosan hydrogels stable at physiological pH and osmolarity and still able to undergo high deformations. Moreover, these systems could be submitted to steam sterilization and could be formulated so as to be injectable. Hence, these hydrogels gathered all the conditions to be good candidates as injectable biomaterials, these hydrogels were then tested in vivo on a rabbit model to evaluate their biocompatibility and suitability for intradermal applications
Tirado, Viloria Patricia Carolina. "New saloplastic biomaterials based on ultracentrifuged polyelectrolyte complexes." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAF034.
This work was aimed to the develop of a new kind of materials of polyelectrolytes complexes. These materials were obtained by the ultracentrifugation of complexes either of natural or synthetic origin. The polyelectrolytes systems as well as the conditions under which these materials could be obtained, followed by the selection of the optimal system to further studies was described. PAA/PAH CoPECs was chosen as synthetic model systems and its physiochemical properties (composition, structure and mechanical properties) were here deeply described. We demonstrated that the composition, structure and mechanical properties can be controlled by changing the assembly conditions (pH, concentration of the polyelectrolytes, [NaCl], speed and order of addition). Moreover, the environmental conditions ([NaCl] and pH) were also used to control the porosity and pores size of the PAA/PAH CoPECs. Finally their ability to serve as scaffold for enzyme immobilization was also studied. We optimized the assembly conditions to keep the maximum of the activity. We also demonstrated that the CoPECs structure provides the stabilization in long term as well as the protection of the enzyme from high temperature. Thus, PAA/PAH CoPECs is a potential and suitable candidates as scaffold for tissue engineering and for the immobilization of enzymes
Faudemer, Gonzague. "Contribution de l'analyse mécanique à l'étude des implants et des biomatériaux dentaires." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-00841306.
Petay, Margaux. "Multimodal and multiscale analysis of complex biomaterials : optimization and constraints of infrared nanospectroscopy measurements." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASF092.
In the biomedical field, understanding the physicochemical changes at the cellular level in tissues can be crucial for unraveling the mechanisms of pathological phenomena. However, the number of techniques providing chemical descriptions at the cellular/molecular level is limited. Infrared (IR) nanospectroscopy techniques, particularly AFM-IR (Atomic Force Microscopy-infrared), are promising as they offer materials' chemical descriptions at the nanometer scale. Up to now, AFM-IR is mainly used in biology for studying individual cells or micro-organisms, but its direct application in biological tissues is relatively scarce due to tissue sections' complex nature. Yet, many applications could benefit from such description, such as mineralization phenomena in breast tissue. Breast microcalcifications (BMCs) are calcium-based deposits (such as calcium oxalate and calcium phosphate) hypothesized to be associated with some breast pathologies, including cancer. Despite increased research over the past decade, BMCs' formation process and connection with breast conditions remain poorly understood. Still, BMCs nanoscale chemical speciation might offer new insights into their chemical architecture. However, breast biopsies typically range from a few millimeters to a few centimeters, containing many BMCs ranging from hundreds of nanometers to a millimeter. Thus, a breast biopsy multiscale characterization strategy is required to provide both a global chemical description of the sample and a fine chemical description of BMCs. We, thus, propose a new multimodal and multiscale approach to investigate BMCs' morphological properties using scanning electron microscopy and their chemical composition at the microscale using IR spectromicroscopy, extending up to the nanometer scale thanks to AFM-IR analysis. Although AFM-IR measurements of inorganic and crystalline objects can be challenging due to their specific optical and mechanical properties, we demonstrate AFM-IR capabilities to characterize pathological deposits directly in biological tissues. Furthermore, implementing a multimodal and multiscale methodology comes with significant challenges in terms of sample preparation, measurements, data processing, and data management, as well as their interpretation: challenges which will be outlined and addressed
Costalat, Marie. "Structure et mécanisme d’élaboration de biomatériaux par complexation contrôlée de polysaccharides." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10265/document.
Our work dealt with the development of a controlled method of polyelectrolyte complexation. The complexation is a spontaneous process, under kinetic control and irreversible in the case of polysaccharides such as the chitosan and polysulfates, essentially dextran sulfate or heparin. A consequence of this kinetic control is the requirement to work at high dilution to obtain objects of colloidal size. Moreover, the obtained nanovectors were not always adapted for use in physiological media. The control of the association of polysaccharides was achieved by screening the attractive electrostatic interactions in the presence of sodium chloride at concentration at least equal to 2 mol. L-1. Removal of salt by dialysis resulted in the formation of hydrogels, whose characteristics and properties depended mainly on the charge ratio n +/ n- and the kinetics of the salt elimination. Thus, massive or dispersed hydrogels were formed at polymer concentrations up to 30 times higher than by the methods under kinetic control. Furthermore, this technology allowed the encapsulation of active ingredients in the particles that could also be functionalized with biomolecules for targeting. The major result of this work was the control over the associations between oppositely charged polysaccharides which provided colloidal and massive systems of high potentialities in biomedical applications
Mujica, Randy. "Layer-by-Layer assembly of nanocellulose composite films with bio-inspired helicoidal superstructures." Thesis, Strasbourg, 2020. http://www.theses.fr/2020STRAE011.
The remarkable optical and mechanical properties of natural materials are often associated with the complexity of their hierarchical structures. One of the most complexes is the helical structure which consists of several layers of unidirectionally aligned fibers whose orientation rotates with respect to their neighboring layers. This so-called Bouligand microstructure is responsible for the enhanced impact resistance of the shell of some crustaceans as well as the preferential reflection of circularly polarized light of certain fruits and insects. Here, we fabricated complex bio-inspired thin films made of cellulose nanofibrils and poly(vinylamine) using the layer-by-layer (LbL) approach and grazing incidence spraying (GIS), a method allowing to control the in-plane alignment of anisotropic nano-objects like cellulose nanofibrils. We demonstrated the independent direction of alignment of each cellulose layer, which allowed the preparation of thin films with well-defined internal structures, namely, unidirectional, cross-ply or helical arrangement of the reinforcing nanofibrils, which is impossible to achieve by any other fabrication process. The optical properties of these films were characterized by circular dichroism (CD) and by Mueller matrix ellipsometry. The chirality observed for helicoidal films is controlled by the rotation direction, the pitch, and the number of layers. The mechanical properties of these cellulose-based films were studied by various nanoindentation methods. A nano-contact fatigue methodology showed an increased ductility of the unidirectional and helicoidal films, which can be indirectly related to enhanced absorption of energy of this material owing to their internal structure
Conference papers on the topic "Biomatériaux complexes":
Gellee, T., and B. Philippe. "Utilisation combinée des biomatériaux xénogéniques et d’os autologue en chirurgie reconstructrice préimplantaire : Réflexions à propos de quatre indications méconnues." In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206602008.
Keller, P. "De la reconstruction simple à la reconstruction complexe, pourquoi prélever de l’os autogène ?" In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206601003.
Catros, S. "A quoi servent les Bio-Imprimantes 3D ?" In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206601012.
Raidot, J., F. Scheid, P. O. Sage, J. M. Offerle, and P. Keller. "Intérêts et techniques de greffe autogène pour la reconstruction de défauts osseux verticaux postérieurs mandibulaires." In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206603006.