Journal articles: 'Biomaterials platform'

1

Okulov, I. V., A. V. Okulov, I. V. Soldatov, B. Luthringer, R. Willumeit-Römer, T. Wada, H. Kato, J. Weissmüller, and J. Markmann. "Open porous dealloying-based biomaterials as a novel biomaterial platform." Materials Science and Engineering: C 88 (July 2018): 95–103. http://dx.doi.org/10.1016/j.msec.2018.03.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Nurzynska, Aleksandra, Katarzyna Klimek, Iga Swierzycka, Krzysztof Palka, and Grazyna Ginalska. "Porous Curdlan-Based Hydrogels Modified with Copper Ions as Potential Dressings for Prevention and Management of Bacterial Wound Infection—An In Vitro Assessment." Polymers 12, no. 9 (August 23, 2020): 1893. http://dx.doi.org/10.3390/polym12091893.

Full text

Abstract:

Bacterial infections at the wound site still remain a huge problem for current medicine, as they may lead to development of chronic wounds. In order to prevent such infections, there is a need to use wound dressings that possess ability to inhibit bacterial colonization. In this study, three new curdlan-based biomaterials modified with copper ions were fabricated via simple and inexpensive procedure, and their structural, physicochemical, and biological properties in vitro were evaluated. Received biomaterials possessed porous structure, had ability to absorb high amount of simulated wound fluid, and importantly, they exhibited satisfactory antibacterial properties. Nevertheless, taking into account all evaluated properties of new curdlan-based biomaterials, it seems that Cur_Cu_8% is the most promising biomaterial for management of wounds accompanied with bacterial infections. This biomaterial exhibited the best ability to reduce Escherichia coli and Staphylococcus aureus growth and moreover, it absorbed the highest amount of simulated wound fluid as well as enabled optimal water vapor transmission. Furthermore, Cur_Cu_8% biomaterial possessed the best values of selective indexes, which determine its potential safety in vitro. Thus, Cur_Cu_8% hydrogel may be considered as a promising candidate for management of infected wounds as well as it may constitute a good platform for further modifications.

APA, Harvard, Vancouver, ISO, and other styles

3

Park, Kijun, Yeontaek Lee, and Jungmok Seo. "Recent Advances in High-throughput Platforms with Engineered Biomaterial Microarrays for Screening of Cell and Tissue Behavior." Current Pharmaceutical Design 24, no. 45 (April 16, 2019): 5458–70. http://dx.doi.org/10.2174/1381612825666190207093438.

Full text

Abstract:

In the last decades, bioengineers have developed myriad biomaterials for regenerative medicine. Development of screening techniques is essential for understanding complex behavior of cells in the biological microenvironments. Conventional approaches to the screening of cellular behavior in vitro have limitations in terms of accuracy, reusability, labor-intensive screening, and versatility. Thus, drug screening and toxicology test through in vitro screening platforms have been underwhelming. Recent advances in the high-throughput screening platforms somewhat overcome the limitations of in vitro screening platforms via repopulating human tissues’ biophysical and biomchemical microenvironments with the ability to continuous monitoring of miniaturized human tissue behavior. Herein, we review current trends in the screening platform in which a high-throughput system composed of engineered microarray devices is developed to investigate cell-biomaterial interaction. Furthermore, diverse methods to achieve continuous monitoring of cell behavior via developments of biosensor integrated high-throughput platforms, and future perspectives on high-throughput screening will be provided.

APA, Harvard, Vancouver, ISO, and other styles

4

Guzzi, Elia A., Giovanni Bovone, and Mark W. Tibbitt. "Universal Nanocarrier Ink Platform for Biomaterials Additive Manufacturing." Small 15, no. 51 (November 25, 2019): 1905421. http://dx.doi.org/10.1002/smll.201905421.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Jayasinghe, Suwan N., Jensen Auguste, and Chris J. Scotton. "Platform Technologies for Directly Reconstructing 3D Living Biomaterials." Advanced Materials 27, no. 47 (October 28, 2015): 7794–99. http://dx.doi.org/10.1002/adma.201503001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Huang, Xiao, Jasper Z. Williams, Ryan Chang, Zhongbo Li, Eric Gai, David M. Patterson, Yu Wei, Wendell A. Lim, and Tejal Desai. "DNA-scaffolded biomaterials enable modular and tunable presentation of proteins to control immune cell therapies." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 86.19. http://dx.doi.org/10.4049/jimmunol.204.supp.86.19.

Full text

Abstract:

Abstract Advanced biomaterials can be used to spatially and temporally control immune cell activities to improve the efficacy and safety of cell therapies. Precise immune cell modulation demands multi-modal display of functional proteins on biomaterials with a high level of control. Here, we developed biodegradable immune cell engaging particles (ICEp) with synthetic short DNA as scaffolds for efficient and tunable protein loading. We demonstrate the precise ratiometric control of anti-CD3 and anti-CD28 antibodies on this biodegradable platform can impact the quality of ex vivo expanded human primary T cells. Furthermore, the high-density presentation of antigens, difficult to achieve by other chemistries, is necessary for controlling the activity of engineered T cells in vivo. Antigen-presenting ICEp injected intratumorally can provide a local priming signal for systemically administered AND-gate chimeric antigen receptor (CAR) T cells that recognize dual antigens: the first antigen on ICEp activates CAR expression to target the second antigen on tumor cells. This leads to local tumor clearance while sparing uninjected tumors that model potentially cross-reactive healthy tissues. This modularly functionalized biomaterial thus provides a flexible platform to achieve sophisticated control of cell-based immunotherapies.

APA, Harvard, Vancouver, ISO, and other styles

7

Houston, Katelyn R., Sarah M. Brosnan, Laurel M. Burk, Yueh Z. Lee, J. C. Luft, and Valerie S. Ashby. "Iodinated polyesters as a versatile platform for radiopaque biomaterials." Journal of Polymer Science Part A: Polymer Chemistry 55, no. 13 (May 2, 2017): 2171–77. http://dx.doi.org/10.1002/pola.28596.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Riha, Shaima Maliha, Manira Maarof, and Mh Busra Fauzi. "Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review." Polymers 13, no. 10 (May 12, 2021): 1546. http://dx.doi.org/10.3390/polym13101546.

Full text

Abstract:

Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.

APA, Harvard, Vancouver, ISO, and other styles

9

Lachowski, Dariusz, Carlos Matellan, Ernesto Cortes, Alberto Saiani, Aline F. Miller, and Armando E. del Río Hernández. "Self-Assembling Polypeptide Hydrogels as a Platform to Recapitulate the Tumor Microenvironment." Cancers 13, no. 13 (June 30, 2021): 3286. http://dx.doi.org/10.3390/cancers13133286.

Full text

Abstract:

The tumor microenvironment plays a critical role in modulating cancer cell migration, metabolism, and malignancy, thus, highlighting the need to develop in vitro culture systems that can recapitulate its abnormal properties. While a variety of stiffness-tunable biomaterials, reviewed here, have been developed to mimic the rigidity of the tumor extracellular matrix, culture systems that can recapitulate the broader extracellular context of the tumor microenvironment (including pH and temperature) remain comparably unexplored, partially due to the difficulty in independently tuning these parameters. Here, we investigate a self-assembled polypeptide network hydrogel as a cell culture platform and demonstrate that the culture parameters, including the substrate stiffness, extracellular pH and temperature, can be independently controlled. We then use this biomaterial as a cell culture substrate to assess the effect of stiffness, pH and temperature on Suit2 cells, a pancreatic cancer cell line, and demonstrate that these microenvironmental factors can regulate two critical transcription factors in cancer: yes-associated protein 1 (YAP) and hypoxia inducible factor (HIF-1A).

APA, Harvard, Vancouver, ISO, and other styles

10

Lesnikowski, Z. "DNA as Platform for New Biomaterials. Metal-Containing Nucleic Acids." Current Organic Chemistry 11, no. 4 (March 1, 2007): 355–81. http://dx.doi.org/10.2174/138527207780059358.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Baino, Francesco. "Copper-Doped Ordered Mesoporous Bioactive Glass: A Promising Multifunctional Platform for Bone Tissue Engineering." Bioengineering 7, no. 2 (May 21, 2020): 45. http://dx.doi.org/10.3390/bioengineering7020045.

Full text

Abstract:

The design and development of biomaterials with multifunctional properties is highly attractive in the context of bone tissue engineering due to the potential of providing multiple therapies and, thus, better treatment of diseases. In order to tackle this challenge, copper-doped silicate mesoporous bioactive glasses (MBGs) were synthesized via a sol-gel route coupled with an evaporation-induced self-assembly process by using a non-ionic block co-polymer as a structure directing agent. The structure and textural properties of calcined materials were investigated by X-ray powder diffraction, scanning-transmission electron microscopy and nitrogen adsorption-desorption measurements. In vitro bioactivity was assessed by immersion tests in simulated body fluid (SBF). Preliminary antibacterial tests using Staphylococcus aureus were also carried out. Copper-doped glasses revealed an ordered arrangement of mesopores (diameter around 5 nm) and exhibited apatite-forming ability in SBF along with promising antibacterial properties. These results suggest the potential suitability of copper-doped MBG powder for use as a multifunctional biomaterial to promote bone regeneration (bioactivity) and prevent/combat microbial infection at the implantation site, thereby promoting tissue healing.

APA, Harvard, Vancouver, ISO, and other styles

12

You, Zhengwei, and Yadong Wang. "A Versatile Synthetic Platform for a Wide Range of Functionalized Biomaterials." Advanced Functional Materials 22, no. 13 (March 30, 2012): 2812–20. http://dx.doi.org/10.1002/adfm.201102024.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Sosnik, Alejandro. "Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art." ISRN Pharmaceutics 2014 (April 9, 2014): 1–17. http://dx.doi.org/10.1155/2014/926157.

Full text

Abstract:

Pharmaceutical research and development aims to design products with ensured safety, quality, and efficacy to treat disease. To make the process more rational, coherent, efficient, and cost-effective, the field of Pharmaceutical Materials Science has emerged as the systematic study of the physicochemical properties and behavior of materials of pharmaceutical interest in relation to product performance. The oral route is the most patient preferred for drug administration. The presence of a mucus layer that covers the entire gastrointestinal tract has been exploited to expand the use of the oral route by developing a mucoadhesive drug delivery system that showed a prolonged residence time. Alginic acid and sodium and potassium alginates have emerged as one of the most extensively explored mucoadhesive biomaterials owing to very good cytocompatibility and biocompatibility, biodegradation, sol-gel transition properties, and chemical versatility that make possible further modifications to tailor their properties. The present review overviews the most relevant applications of alginate microparticles and nanoparticles for drug administration by the oral route and discusses the perspectives of this biomaterial in the future.

APA, Harvard, Vancouver, ISO, and other styles

14

Melero, Anna, Andre Senna, Juliana Domingues, Adriana Motta, Moema Haussen, Antonio Riul Junior, Eliana Duek, and Vagner Botaro. "Chelating Effect of Cellulose Acetate Hydrogel Crosslinked with EDTA Dianhydride Used as a Platform for Cell Growth." Advances in Materials Science and Engineering 2019 (September 15, 2019): 1–11. http://dx.doi.org/10.1155/2019/8684753.

Full text

Abstract:

The use of biomaterials capable of achieving controlled release of drugs or chemical and physical interactions with living organisms causes these new materials to be studied in depth to better target their future applications. An example of this is the use of materials that have in their physical structure elements with chelating effects, capable of interacting with the ions and cations present in the cell culture media, drugs, and other elements capable of interacting with the human body. In this work, cellulose acetate hydrogel (HAC) crosslinked with EDTAD (ethylenediaminetetraacetic acid dianhydride) showed a significant chelating effect capable of altering the adhesion of mesenchymal cells in the first days of in vitro tests. This result became our main question in this work, and by using new cell viability assays, it was verified that the hydrogel interacted with the culture medium, removed the salts present, such as Ca2+ and Mg2+, and promoted a decrease in the amount of cells adhered to the material but not cell death. After saturation of Ca2+ and Mg2+, we obtained an improvement in cell adhesion. Electrochemical impedance spectroscopy (EIS) results also verified the dynamics of linked or mobile loads in the volume and interface regions of HAC-EDTA and the presence of characteristic bands related to the interaction between calcium and magnesium present in the culture medium with HAC-EDTA. The DMA traction test showed that there was no dynamic-mechanical change in the structure of the material at temperatures between 20 and 60°C, which is ideal for this studied biomaterial. The purpose of these tests is to aid in the characterization of future biomaterials, where the physicochemical interaction of some of them is often confused with a false cytotoxicity, which in fact may only be an easily identifiable and adaptable structural feature.

APA, Harvard, Vancouver, ISO, and other styles

15

Yu, JunJie, Su A. Park, Wan Doo Kim, Taeho Ha, Yuan-Zhu Xin, JunHee Lee, and Donghyun Lee. "Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering." Polymers 12, no. 12 (December 11, 2020): 2958. http://dx.doi.org/10.3390/polym12122958.

Full text

Abstract:

Three-dimensional (3D) bioprinting technology has emerged as a powerful biofabrication platform for tissue engineering because of its ability to engineer living cells and biomaterial-based 3D objects. Over the last few decades, droplet-based, extrusion-based, and laser-assisted bioprinters have been developed to fulfill certain requirements in terms of resolution, cell viability, cell density, etc. Simultaneously, various bio-inks based on natural–synthetic biomaterials have been developed and applied for successful tissue regeneration. To engineer more realistic artificial tissues/organs, mixtures of bio-inks with various recipes have also been developed. Taken together, this review describes the fundamental characteristics of the existing bioprinters and bio-inks that have been currently developed, followed by their advantages and disadvantages. Finally, various tissue engineering applications using 3D bioprinting are briefly introduced.

APA, Harvard, Vancouver, ISO, and other styles

16

Li, Jia, Bo-Xiang Wang, De-Hong Cheng, and Yan-Hua Lu. "Eco-Friendly Bio-Hydrogels Based on Antheraea Pernyi Silk Gland Protein for Cell and Drug Delivery." Gels 8, no. 7 (June 23, 2022): 398. http://dx.doi.org/10.3390/gels8070398.

Full text

Abstract:

The Antheraea Pernyi silk gland protein originates from natural organisms and synthesized by tussah silk glands and has widely potential biomaterial applications due to the superior biocompatibility. This study investigates the Antheraea Pernyi silk gland protein-based drug-loaded bio-hydrogels for bioengineered tissue fabricated by using an eco-friendly method without the harsh extracting process and the usage of toxic chemicals. The drug-loaded bio-hydrogels exhibited a porous structure and interconnected pore walls. The swelling ratio and water absorption of drug-loaded bio-hydrogels were, respectively, above 95% and 1.5 × 103%. The cumulative release of drug loaded hydrogels all reached more than 90% within 4 h, and this indicates the potential of drug-loaded hydrogels as future drug-carrying biomaterials. RSC96 Schwann cells cultured on drug-loaded hydrogels for 72 h under cell culture medium show no toxic effects and more pro-proliferative effects. The results suggest the suitability of drug-loaded bio-hydrogels as natural biopolymer for the potential in vitro RSC96 cell culture platform and other biomaterial applications.

APA, Harvard, Vancouver, ISO, and other styles

17

Palacio-Castañeda, Valentina, Rik Oude Egberink, Arbaaz Sait, Lea Andrée, Benedetta Maria Sala, Negar Hassani Besheli, Egbert Oosterwijk, et al. "Mimicking the Biology of Engineered Protein and mRNA Nanoparticle Delivery Using a Versatile Microfluidic Platform." Pharmaceutics 13, no. 11 (November 17, 2021): 1944. http://dx.doi.org/10.3390/pharmaceutics13111944.

Full text

Abstract:

To investigate the delivery of next-generation macromolecular drugs, such as engineered proteins and mRNA-containing nanoparticles, there is an increasing push towards the use of physiologically relevant disease models that incorporate human cells and do not face ethical dilemmas associated with animal use. Here, we illustrate the versatility and ease of use of a microfluidic platform for studying drug delivery using high-resolution microscopy in 3D. Using this microfluidic platform, we successfully demonstrate the specific targeting of carbonic anhydrase IX (CAIX) on cells overexpressing the protein in a tumor-mimicking chip system using affibodies, with CAIX-negative cells and non-binding affibodies as controls. Furthermore, we demonstrate this system’s feasibility for testing mRNA-containing biomaterials designed to regenerate bone defects. To this end, peptide- and lipid-based mRNA formulations were successfully mixed with colloidal gelatin in microfluidic devices, while translational activity was studied by the expression of a green fluorescent protein. This microfluidic platform enables the testing of mRNA delivery from colloidal biomaterials of relatively high densities, which represents a first important step towards a bone-on-a-chip platform. Collectively, by illustrating the ease of adaptation of our microfluidic platform towards use in distinct applications, we show that our microfluidic chip represents a powerful and flexible way to investigate drug delivery in 3D disease-mimicking culture systems that recapitulate key parameters associated with in vivo drug application.

APA, Harvard, Vancouver, ISO, and other styles

18

Chan, Ming-Hsien, Zhi-Xuan Chang, Chi-Ying F. Huang, L. James Lee, Ru-Shi Liu, and Michael Hsiao. "Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment." Nanoscale Horizons 7, no. 4 (2022): 352–67. http://dx.doi.org/10.1039/d1nh00637a.

Full text

Abstract:

Hybrid inorganic/organic nanoparticles with exosomes can be applied as a novel platform for drug delivery systems. This biomimetic nanoplatform combines the functions of natural biomaterials to efficiently carry drugs to the center of cancer cells.

APA, Harvard, Vancouver, ISO, and other styles

19

Vainieri, Maria L., Mauro Alini, Avner Yayon, Gerjo J. V. M. van Osch, and Sibylle Grad. "Mechanical Stress Inhibits Early Stages of Endogenous Cell Migration: A Pilot Study in an Ex Vivo Osteochondral Model." Polymers 12, no. 8 (August 6, 2020): 1754. http://dx.doi.org/10.3390/polym12081754.

Full text

Abstract:

Cell migration has a central role in osteochondral defect repair initiation and biomaterial-mediated regeneration. New advancements to reestablish tissue function include biomaterials and factors promoting cell recruitment, differentiation and tissue integration, but little is known about responses to mechanical stimuli. In the present pilot study, we tested the influence of extrinsic forces in combination with biomaterials releasing chemoattractant signals on cell migration. We used an ex vivo mechanically stimulated osteochondral defect explant filled with fibrin/hyaluronan hydrogel, in presence or absence of platelet-derived growth factor-BB or stromal cell-derived factor 1, to assess endogenous cell recruitment into the wound site. Periodic mechanical stress at early time point negatively influenced cell infiltration compared to unloaded samples, and the implementation of chemokines to increase cell migration was not efficient to overcome this negative effect. The gene expression at 15 days of culture indicated a marked downregulation of matrix metalloproteinase (MMP)13 and MMP3, a decrease of β1 integrin and increased mRNA levels of actin in osteochondral samples exposed to complex load. This work using an ex vivo osteochondral mechanically stimulated advanced platform demonstrated that recurrent mechanical stress at early time points impeded cell migration into the hydrogel, providing a unique opportunity to improve our understanding on management of joint injury.

APA, Harvard, Vancouver, ISO, and other styles

20

Shin, Dong-Myeong, Suck Won Hong, and Yoon-Hwae Hwang. "Recent Advances in Organic Piezoelectric Biomaterials for Energy and Biomedical Applications." Nanomaterials 10, no. 1 (January 9, 2020): 123. http://dx.doi.org/10.3390/nano10010123.

Full text

Abstract:

The past decade has witnessed significant advances in medically implantable and wearable devices technologies as a promising personal healthcare platform. Organic piezoelectric biomaterials have attracted widespread attention as the functional materials in the biomedical devices due to their advantages of excellent biocompatibility and environmental friendliness. Biomedical devices featuring the biocompatible piezoelectric materials involve energy harvesting devices, sensors, and scaffolds for cell and tissue engineering. This paper offers a comprehensive review of the principles, properties, and applications of organic piezoelectric biomaterials. How to tackle issues relating to the better integration of the organic piezoelectric biomaterials into the biomedical devices is discussed. Further developments in biocompatible piezoelectric materials can spark a new age in the field of biomedical technologies.

APA, Harvard, Vancouver, ISO, and other styles

21

Moroni, L., A. van Boxtel, C. A. van Blitterswijk, and G. A. Higuera. "420 A Platform of Porous Biomaterials as 3D Culture Systems for Cancer Biology." European Journal of Cancer 48 (July 2012): S102. http://dx.doi.org/10.1016/s0959-8049(12)71102-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Soares, Diana G., Ester A. F. Bordini, W. Benton Swanson, Carlos A. de Souza Costa, and Marco C. Bottino. "Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies." Clinical Oral Investigations 25, no. 8 (June 28, 2021): 4749–79. http://dx.doi.org/10.1007/s00784-021-04013-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Kim, Hyeongmin, and Jaehwi Lee. "Strategies to Maximize the Potential of Marine Biomaterials as a Platform for Cell Therapy." Marine Drugs 14, no. 2 (January 26, 2016): 29. http://dx.doi.org/10.3390/md14020029.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Bagó, Juli R., Elisabeth Aguilar, Maria Alieva, Carolina Soler-Botija, Olaia F. Vila, Silvia Claros, José A. Andrades, José Becerra, Nuria Rubio, and Jerónimo Blanco. "In Vivo Bioluminescence Imaging of Cell Differentiation in Biomaterials: A Platform for Scaffold Development." Tissue Engineering Part A 19, no. 5-6 (March 2013): 593–603. http://dx.doi.org/10.1089/ten.tea.2012.0073.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Piñón, Tessa M., Alessandro R. Castelli, Linda S. Hirst, and Jay E. Sharping. "Fiber-optic trap-on-a-chip platform for probing low refractive index contrast biomaterials." Applied Optics 52, no. 11 (April 8, 2013): 2340. http://dx.doi.org/10.1364/ao.52.002340.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Liu, Wen-Dong, and Bai Yang. "Patterned surfaces for biological applications: A new platform using two dimensional structures as biomaterials." Chinese Chemical Letters 28, no. 4 (April 2017): 675–90. http://dx.doi.org/10.1016/j.cclet.2016.09.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Mendoza-Martinez, Ana Karen, Daniela Loessner, Alvaro Mata, and Helena S. Azevedo. "Modeling the Tumor Microenvironment of Ovarian Cancer: The Application of Self-Assembling Biomaterials." Cancers 13, no. 22 (November 16, 2021): 5745. http://dx.doi.org/10.3390/cancers13225745.

Full text

Abstract:

Ovarian cancer (OvCa) is one of the leading causes of gynecologic malignancies. Despite treatment with surgery and chemotherapy, OvCa disseminates and recurs frequently, reducing the survival rate for patients. There is an urgent need to develop more effective treatment options for women diagnosed with OvCa. The tumor microenvironment (TME) is a key driver of disease progression, metastasis and resistance to treatment. For this reason, 3D models have been designed to represent this specific niche and allow more realistic cell behaviors compared to conventional 2D approaches. In particular, self-assembling peptides represent a promising biomaterial platform to study tumor biology. They form nanofiber networks that resemble the architecture of the extracellular matrix and can be designed to display mechanical properties and biochemical motifs representative of the TME. In this review, we highlight the properties and benefits of emerging 3D platforms used to model the ovarian TME. We also outline the challenges associated with using these 3D systems and provide suggestions for future studies and developments. We conclude that our understanding of OvCa and advances in materials science will progress the engineering of novel 3D approaches, which will enable the development of more effective therapies.

APA, Harvard, Vancouver, ISO, and other styles

28

Tacchi, Franco, Josué Orozco-Aguilar, Danae Gutiérrez, Felipe Simon, Javier Salazar, Cristian Vilos, and Claudio Cabello-Verrugio. "Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration." Nanomedicine 16, no. 28 (December 2021): 2521–38. http://dx.doi.org/10.2217/nnm-2021-0224.

Full text

Abstract:

Skeletal muscle is integral to the functioning of the human body. Several pathological conditions, such as trauma (primary lesion) or genetic diseases such as Duchenne muscular dystrophy (DMD), can affect and impair its functions or exceed its regeneration capacity. Tissue engineering (TE) based on natural, synthetic and hybrid biomaterials provides a robust platform for developing scaffolds that promote skeletal muscle regeneration, strength recovery, vascularization and innervation. Recent 3D-cell printing technology and the use of nanocarriers for the release of drugs, peptides and antisense oligonucleotides support unique therapeutic alternatives. Here, the authors present recent advances in scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration and perspectives for future endeavors.

APA, Harvard, Vancouver, ISO, and other styles

29

Griesser, Stefani S., Marek Jasieniak, Krasimir Vasilev, and Hans J. Griesser. "Antimicrobial Peptides Grafted onto a Plasma Polymer Interlayer Platform: Performance upon Extended Bacterial Challenge." Coatings 11, no. 1 (January 8, 2021): 68. http://dx.doi.org/10.3390/coatings11010068.

Full text

Abstract:

To combat infections on biomedical devices, antimicrobial coatings have attracted considerable attention, including coatings comprising naturally occurring antimicrobial peptides (AMPs). In this study the aim was to explore performance upon extended challenge by bacteria growing in media above samples. The AMPs LL37, Magainin 2, and Parasin 1 were selected on the basis of well-known membrane disruption activity in solution and were covalently grafted onto a plasma polymer platform, which enables application of this multilayer coating strategy to a wide range of biomaterials. Detailed surface analyses were performed to verify the intended outcomes of the coating sequence. Samples were challenged by incubation in bacterial growth media for 5 and 20 h. Compared with the control plasma polymer surface, all three grafted AMP coatings showed considerable reductions in bacterial colonization even at the high bacterial challenge of initial seeding at 1 × 107 CFU, but there were increasing numbers of dead bacteria attached to the surface. All three grafted AMP coatings were found to be non-toxic to primary fibroblasts. These coatings thus could be useful to produce antibacterial surface coatings for biomaterials, though possible consequences arising from the presence of dead bacteria need to be studied further, and compared to non-fouling coatings that avoid attachment of dead bacteria.

APA, Harvard, Vancouver, ISO, and other styles

30

Griesser, Stefani S., Marek Jasieniak, Krasimir Vasilev, and Hans J. Griesser. "Antimicrobial Peptides Grafted onto a Plasma Polymer Interlayer Platform: Performance upon Extended Bacterial Challenge." Coatings 11, no. 1 (January 8, 2021): 68. http://dx.doi.org/10.3390/coatings11010068.

Full text

Abstract:

To combat infections on biomedical devices, antimicrobial coatings have attracted considerable attention, including coatings comprising naturally occurring antimicrobial peptides (AMPs). In this study the aim was to explore performance upon extended challenge by bacteria growing in media above samples. The AMPs LL37, Magainin 2, and Parasin 1 were selected on the basis of well-known membrane disruption activity in solution and were covalently grafted onto a plasma polymer platform, which enables application of this multilayer coating strategy to a wide range of biomaterials. Detailed surface analyses were performed to verify the intended outcomes of the coating sequence. Samples were challenged by incubation in bacterial growth media for 5 and 20 h. Compared with the control plasma polymer surface, all three grafted AMP coatings showed considerable reductions in bacterial colonization even at the high bacterial challenge of initial seeding at 1 × 107 CFU, but there were increasing numbers of dead bacteria attached to the surface. All three grafted AMP coatings were found to be non-toxic to primary fibroblasts. These coatings thus could be useful to produce antibacterial surface coatings for biomaterials, though possible consequences arising from the presence of dead bacteria need to be studied further, and compared to non-fouling coatings that avoid attachment of dead bacteria.

APA, Harvard, Vancouver, ISO, and other styles

31

Lu, Shao-Lun, Pei-Yu Chao, Wei-Wen Liu, Kun Han, Jason Chia-Hsien Cheng, and Pai-Chi Li. "Longitudinal shear wave elasticity measurements of millimeter-sized biomaterials using a single-element transducer platform." PLOS ONE 17, no. 4 (April 6, 2022): e0266235. http://dx.doi.org/10.1371/journal.pone.0266235.

Full text

Abstract:

Temporal variations of the extracellular matrix (ECM) stiffness profoundly impact cellular behaviors, possibly more significantly than the influence of static stiffness. Three-dimensional (3D) cell cultures with tunable matrix stiffness have been utilized to characterize the mechanobiological interactions of elasticity-mediated cellular behaviors. Conventional studies usually perform static interrogations of elasticity at micro-scale resolution. While such studies are essential for investigations of cellular mechanotransduction, few tools are available for depicting the temporal dynamics of the stiffness of the cellular environment, especially for optically turbid millimeter-sized biomaterials. We present a single-element transducer shear wave (SW) elasticity imaging system that is applied to a millimeter-sized, ECM-based cell-laden hydrogel. The single-element ultrasound transducer is used both to generate SWs and to detect their arrival times after being reflected from the side boundaries of the sample. The sample’s shear wave speed (SWS) is calculated by applying a time-of-flight algorithm to the reflected SWs. We use this noninvasive and technically straightforward approach to demonstrate that exposing 3D cancer cell cultures to X-ray irradiation induces a temporal change in the SWS. The proposed platform is appropriate for investigating in vitro how a group of cells remodels their surrounding matrix and how changes to their mechanical properties could affect the embedded cells in optically turbid millimeter-sized biomaterials.

APA, Harvard, Vancouver, ISO, and other styles

32

Misawa, Nobuo, Toshihisa Osaki, and Shoji Takeuchi. "Membrane protein-based biosensors." Journal of The Royal Society Interface 15, no. 141 (April 2018): 20170952. http://dx.doi.org/10.1098/rsif.2017.0952.

Full text

Abstract:

This review highlights recent development of biosensors that use the functions of membrane proteins. Membrane proteins are essential components of biological membranes and have a central role in detection of various environmental stimuli such as olfaction and gustation. A number of studies have attempted for development of biosensors using the sensing property of these membrane proteins. Their specificity to target molecules is particularly attractive as it is significantly superior to that of traditional human-made sensors. In this review, we classified the membrane protein-based biosensors into two platforms: the lipid bilayer-based platform and the cell-based platform. On lipid bilayer platforms, the membrane proteins are embedded in a lipid bilayer that bridges between the protein and a sensor device. On cell-based platforms, the membrane proteins are expressed in a cultured cell, which is then integrated in a sensor device. For both platforms we introduce the fundamental information and the recent progress in the development of the biosensors, and remark on the outlook for practical biosensing applications.

APA, Harvard, Vancouver, ISO, and other styles

33

Câmara-Pereira, Eliana dos Santos, Ana Emília Holanda Rolim, Evelyn Reale, Rafael Barreto, Lilian Campos, Aryon de Almeida Barbosa Junior, Alexandre Malta Rossi, Silvia Rachel de Albuquerque-Santos, and Fabiana Paim Rosa. "Analysis of Bone Repair Tissue after Implantation of Biomaterials and Application of Vibratory Waves." Materials Science Forum 775-776 (January 2014): 9–12. http://dx.doi.org/10.4028/www.scientific.net/msf.775-776.9.

Full text

Abstract:

Bone tissue in ideal conditions morphofunctional remodeling properly. The bone can be affected by fractures, tumors, hormonal dysfunction, senescence, genetic modifications, among others. In such circumstances, the proper diet, drug use, exercise and other factors are important to the prevention of bone mineral loss. The effect of kinesiotherapy obtained through the application of vibratory waves administered through the vibrating platform, Juvent1000 ® already been established in the prevention of bone mineral density, muscular trophism, among other systems in humans. The response by analyzing bone tissue of bone repair in critical defect is not known in experimental animals and in human clinical. This research evaluated the osteogenic potential critical defect in the calvaria of rats subjected to the application of vibratory waves obtained by vibrating platform and implant in the critical defect of rat calvaria. The bone tissue response was evaluated showed satisfactory results obtained in biological points 15, 45 and 120 days.

APA, Harvard, Vancouver, ISO, and other styles

34

Baláž, Matej. "Eggshell membrane biomaterial as a platform for applications in materials science." Acta Biomaterialia 10, no. 9 (September 2014): 3827–43. http://dx.doi.org/10.1016/j.actbio.2014.03.020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Kucherov, Yu S., V. N. Lobanov, V. S. Medovy, M. I. Cheldiev, and P. B. Chuchkalov. "SYSTEM OF AUTOMATIC MICROSCOPIC ANALYSIS OF BIOMATERIALS FOR DIAGNOSTICS OF ONCOLOGICAL PATHOLOGIES USING TRAINED NEURAL NETWORKS AND TELEMEDICAL CONSULTATIONS." Issues of radio electronics, no. 5 (June 8, 2019): 76–81. http://dx.doi.org/10.21778/2218-5453-2019-5-76-81.

Full text

Abstract:

Labor intensity, complexity of morphology, the shortage of qualified specialists do not allow full use of the diagnostic potential of microscopic analysis of biomaterials in mass population surveys. The article discusses the technology of creating an Automatic Scan Microscope Analyzer of Oncological Pathologies (ASMAOP) that uses neural network learning during regular telemedicine consultations with expert evaluation of digital copies of biomaterials produced by a scanning microscope. The scheme of work of ASMAOP in the composition of a telemedicine network, hardware solutions including platform for deep learning are considered. The purpose of creation of ASMAOP is to perform microscopic analyses at the level of the experienced experts with a significant advantage in performance and availability.

APA, Harvard, Vancouver, ISO, and other styles

36

Hendrikse, Simone I. S., Sergio Spaans, E. W. Meijer, and Patricia Y. W. Dankers. "Supramolecular Platform Stabilizing Growth Factors." Biomacromolecules 19, no. 7 (April 20, 2018): 2610–17. http://dx.doi.org/10.1021/acs.biomac.8b00219.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Barata, D., E. Provaggi, C. van Blitterswijk, and P. Habibovic. "Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study cell–material interactions." Lab on a Chip 17, no. 23 (2017): 4134–47. http://dx.doi.org/10.1039/c7lc00802c.

Full text

Abstract:

Microfluidic screening platforms offer new possibilities for performingin vitrocell-based assays with higher throughput and in a setting that has the potential to closely mimic the physiological microenvironment.

APA, Harvard, Vancouver, ISO, and other styles

38

Mas-Moruno, Carlos, Roberta Fraioli, Fernando Albericio, José María Manero, and F. Javier Gil. "Novel Peptide-Based Platform for the Dual Presentation of Biologically Active Peptide Motifs on Biomaterials." ACS Applied Materials & Interfaces 6, no. 9 (April 15, 2014): 6525–36. http://dx.doi.org/10.1021/am5001213.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

BECKER, MATTHEW, DILLON SEROSKI, SCOTT STIMPSON, CLAYTON E. MATHEWS, GREG HUDALLA, and EDWARD A. PHELPS. "Supramolecular Biomaterials as a Biomimetic Platform for Investigating Immunopathological Processes of Human Type 1 Diabetes." Diabetes 67, Supplement 1 (May 2018): 99—OR. http://dx.doi.org/10.2337/db18-99-or.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Lahr, Christoph A., Marietta Landgraf, Alvaro Sanchez-Herrero, Hoang Phuc Dang, Ferdinand Wagner, Onur Bas, Laura J. Bray, et al. "A 3D-printed biomaterials-based platform to advance established therapy avenues against primary bone cancers." Acta Biomaterialia 118 (December 2020): 69–82. http://dx.doi.org/10.1016/j.actbio.2020.10.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Tomić, Simonida Lj, Jovana S. Vuković, Marija M. Babić Radić, Vuk V. Filipović, Dubravka P. Živanović, Miloš M. Nikolić, and Jasmina Nikodinovic-Runic. "Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration." Polymers 15, no. 3 (January 24, 2023): 589. http://dx.doi.org/10.3390/polym15030589.

Full text

Abstract:

Scaffolding biomaterials are gaining great importance due to their beneficial properties for medical purposes. Targeted biomaterial engineering strategies through the synergy of different material types can be applied to design hybrid scaffolding biomaterials with advantageous properties for biomedical applications. In our research, a novel combination of the bioactive agent Manuka honey (MHo) with 2-hydroxyethyl methacrylate/gelatin (HG) hydrogel scaffolds was created as an efficient bioactive platform for biomedical applications. The effects of Manuka honey content on structural characteristics, porosity, swelling performance, in vitro degradation, and in vitro biocompatibility (fibroblast and keratinocyte cell lines) of hybrid hydrogel scaffolds were studied using Fourier transform infrared spectroscopy, the gravimetric method, and in vitro MTT biocompatibility assays. The engineered hybrid hydrogel scaffolds show advantageous properties, including porosity in the range of 71.25% to 90.09%, specific pH- and temperature-dependent swelling performance, and convenient absorption capacity. In vitro degradation studies showed scaffold degradability ranging from 6.27% to 27.18% for four weeks. In vitro biocompatibility assays on healthy human fibroblast (MRC5 cells) and keratinocyte (HaCaT cells) cell lines by MTT tests showed that cell viability depends on the Manuka honey content loaded in the HG hydrogel scaffolds. A sample containing the highest Manuka honey content (30%) exhibited the best biocompatible properties. The obtained results reveal that the synergy of the bioactive agent, Manuka honey, with 2-hydroxyethyl methacrylate/gelatin as hybrid hydrogel scaffolds has potential for biomedical purposes. By tuning the Manuka honey content in HG hydrogel scaffolds advantageous properties of hybrid scaffolds can be achieved for biomedical applications.

APA, Harvard, Vancouver, ISO, and other styles

42

Xu, Weigao, Nannan Mao, and Jin Zhang. "Graphene: A Platform for Surface-Enhanced Raman Spectroscopy." Small 9, no. 8 (March 26, 2013): 1206–24. http://dx.doi.org/10.1002/smll.201203097.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Han, Sheng, Dongqing Wu, Shuang Li, Fan Zhang, and Xinliang Feng. "Graphene: A Two-Dimensional Platform for Lithium Storage." Small 9, no. 8 (March 13, 2013): 1173–87. http://dx.doi.org/10.1002/smll.201203155.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Gudziunas, Vaidotas, Aurelijus Domeika, Linas Puodžiukynas, and Renata Gustiene. "Quantitative assessment of the level of instability of a single-plane balance platform." Technology and Health Care 30, no. 1 (December 29, 2021): 291–307. http://dx.doi.org/10.3233/thc-219011.

Full text

Abstract:

BACKGROUND: Balance training on unstable surfaces is widely used in medicine and sports. The main disadvantage of balance platforms is weakly definable assessment of the level of instability (IL) they create. OBJECTIVE: To evaluate the mechanical characteristics of a suspended single-plane instability balance platform which determines quantitative instability characteristics. METHODS: Three criteria influencing the IL were evaluated: 1. The displacement of the platform board by changing the position of the object on the board; 2. Amount of force required for board displacement; 3. The vibration damping of the platform. RESULTS: 1. 1IL the displacement of the object on the board affected 0.66 cm. the displacement of the board relative to the platform frame; 2IL – 0.79 cm; 3IL – 0.91 cm.; 2. A force of 2.64 is required for a board displacement of 1IL compared to 2IL and 5.76 times that of 3IL. 3. Damping factor 1IL – 0.015, 2IL – 0.006, 3IL – 0.003. CONCLUSIONS: 1. The longer the suspension, the change in the position of the object on the board affects the greater movement of the board relative to the platform. 2. Different IL can be compared with each other depending on how different the force required to cause the board to move. 3. The platform dampens vibrations weakly, but the damping between 1 and 3 IL differs about 5 times.

APA, Harvard, Vancouver, ISO, and other styles

45

França, Cristiane Miranda, Anthony Tahayeri, Nara Sousa Rodrigues, Shirin Ferdosian, Regina Maria Puppin Rontani, Grigoriy Sereda, Jack L. Ferracane, and Luiz E. Bertassoni. "The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials." Lab on a Chip 20, no. 2 (2020): 405–13. http://dx.doi.org/10.1039/c9lc00915a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Ellis, Morgan, and Elizabeth Lipke. "3094 Production of Engineered Cardiac Tissue for Disease Modeling." Journal of Clinical and Translational Science 3, s1 (March 2019): 18–19. http://dx.doi.org/10.1017/cts.2019.45.

Full text

Abstract:

OBJECTIVES/SPECIFIC AIMS: Cardiovascular diseases (CVD) is the leading cause of death worldwide in both men and women due to lack of cardiac regeneration after disease or damaged is caused. There are many challenges to studying CVD since native cardiomyocytes cannot be cultured in vitro. With the advancements in biomaterial and pluripotent stem cells research, scientists are now able to produce engineered cardiac tissue models in vitro that mimic the native myocardium. This study shows our methods for producing engineered cardiac tissue with potential applications in cardiac regeneration, disease modeling, and scalable production. METHODS/STUDY POPULATION: In this study, human induced pluripotent stem cells (hiPSCs) were combined with two different photocrosslinkable hybrid biomaterials, poly (ethylene)- glycol fibrinogen (PF) and gelatin methacrylate (GelMa), in various tissue geometries to form 3D human engineered cardiac tissues (3D-hECTs). To study tissue growth and contraction, image and video analysis was performed at specific timepoints. To analyze differentiation efficiency and cell population, flow cytometry was performed using cardiac markers. To evaluate gene expression, qPCR was performed using pluripotency and cardiac specific primers. RESULTS/ANTICIPATED RESULTS: Direct cardiac differentiation of encapsulated hiPSCs resulted in synchronously contracting 3D-hECTs in both biomaterials and all tissue geometries. Spontaneous contractions started on Day 7 and increased in velocity, frequency, and synchronicity over time. 3D-hECTs had high cell viability with > 70% of cells positive for cardiac markers. Engineered tissues showed appropriate temporal changes in gene expression over time with pluripotency gene expression decreasing and cardiac gene expression increasing. DISCUSSION/SIGNIFICANCE OF IMPACT: This study shows the potential for direct differentiation of encapsulated hiPSCs to produce physiologically relevant engineered cardiac tissues. Resulting 3D-hECTS showed features of mature myocardium with appropriate cardiomyocyte populations, mechanical motion, and gene expression. Using this platform, we are able to produce engineered cardiac tissue in a variety of biomaterials and tissue geometries to study new therapeutics, mechanism of disease, and scalable tissue culture.

APA, Harvard, Vancouver, ISO, and other styles

47

Ferreira, Mónica V., Wilhelm Jahnen-Dechent, and Sabine Neuss. "Standardization of Automated Cell-Based Protocols for Toxicity Testing of Biomaterials." Journal of Biomolecular Screening 16, no. 6 (April 25, 2011): 647–54. http://dx.doi.org/10.1177/1087057111405380.

Full text

Abstract:

Advances in high-throughput screening (HTS) instrumentation have led to enormous reduction of costs (e.g., of pipetting stations) and to the development of smaller instruments for automation of day-to-day routines in small research laboratories. In the biomaterials community, there has been an increasing interest for standardized screening protocols to identify cell type–specific cytocompatible biomaterials suitable for tissue engineering (TE) applications. In this study, the authors established a multiplexed assay protocol for toxicity screening of biomaterials using a low- to medium-throughput robotic liquid handling station (LHS). The protocol contains analysis of viability, cytotoxicity, and apoptosis combined in one assay. This study includes performance results of a side-by-side comparison of the EpMotion 5070 LHS and conventional pipetting/dispensing systems. Critical parameters were optimized each for a given platform. Higher accuracy and reproducibility were achieved for LHS compared to manually treated samples. The practicability and accuracy of the method in a typical small laboratory setting were tested by running daily routine tasks by trained and untrained laboratory staff. In addition, advantages and disadvantages as well as the step-by-step application protocol are reported. The approach described provides a potential utility in screening biomaterials toxicity, allowing researchers to meet the needs of low- and medium-throughput laboratories.

APA, Harvard, Vancouver, ISO, and other styles

48

Zhao, Gaoqian, Jiaxin Li, Fangfang lv, Xiaochun Wang, Qing Dong, Dandan Liu, Jinchao Zhang, Zhenhua Li, Xiaohan Zhou, and Huifang Liu. "Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy." ACS Biomaterials Science & Engineering 7, no. 11 (October 12, 2021): 5154–64. http://dx.doi.org/10.1021/acsbiomaterials.1c00912.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Sokullu, Emel, Zeynel Levent Cücük, Misagh Rezapour Sarabi, Mehmet Tugrul Birtek, Hesam Saghaei Bagheri, and Savas Tasoglu. "Microfluidic Invasion Chemotaxis Platform for 3D Neurovascular Co-Culture." Fluids 7, no. 7 (July 13, 2022): 238. http://dx.doi.org/10.3390/fluids7070238.

Full text

Abstract:

Advances in microfabrication and biomaterials have enabled the development of microfluidic chips for studying tissue and organ models. While these platforms have been developed primarily for modeling human diseases, they are also used to uncover cellular and molecular mechanisms through in vitro studies, especially in the neurovascular system, where physiological mechanisms and three-dimensional (3D) architecture are difficult to reconstruct via conventional assays. An extracellular matrix (ECM) model with a stable structure possessing the ability to mimic the natural extracellular environment of the cell efficiently is useful for tissue engineering applications. Conventionally used techniques for this purpose, for example, Matrigels, have drawbacks of owning complex fabrication procedures, in some cases not efficient enough in terms of functionality and expenses. Here, we proposed a fabrication protocol for a GelMA hydrogel, which has shown structural stability and the ability to imitate the natural environment of the cell accurately, inside a microfluidic chip utilizing co-culturing of two human cell lines. The chemical composition of the synthesized GelMA was identified by Fourier transform infrared spectrophotometry (FTIR), its surface morphology was observed by field emission electron microscopy (FESEM), and the structural properties were analyzed by atomic force microscopy (AFM). The swelling behavior of the hydrogel in the microfluidic chip was imaged, and its porosity was examined for 72 h by tracking cell localization using immunofluorescence. GelMA exhibited the desired biomechanical properties, and the viability of cells in both platforms was more than 80% for seven days. Furthermore, GelMA was a viable platform for 3D cell culture studies and was structurally stable over long periods, even when prepared by photopolymerization in a microfluidic platform. This work demonstrated a viable strategy to conduct co-culturing experiments as well as modeling invasion and migration events. This microfluidic assay may have application in drug delivery and dosage optimization studies.

APA, Harvard, Vancouver, ISO, and other styles

50

Moraes, Christopher, GongHao Wang, Yu Sun, and Craig A. Simmons. "A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays." Biomaterials 31, no. 3 (January 2010): 577–84. http://dx.doi.org/10.1016/j.biomaterials.2009.09.068.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Biomaterials platform'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles