Relevant bibliographies by topics / Biomaterials for orthopedic applications

Academic literature on the topic 'Biomaterials for orthopedic applications'

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Published: 6 September 2023

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Journal articles on the topic "Biomaterials for orthopedic applications"

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Allizond, Valeria, Sara Comini, Anna Maria Cuffini, and Giuliana Banche. "Current Knowledge on Biomaterials for Orthopedic Applications Modified to Reduce Bacterial Adhesive Ability." Antibiotics 11, no. 4 (April 15, 2022): 529. http://dx.doi.org/10.3390/antibiotics11040529.

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A significant challenge in orthopedics is the design of biomaterial devices that are able to perform biological functions by substituting or repairing various tissues and controlling bone repair when required. This review presents an overview of the current state of our recent research into biomaterial modifications to reduce bacterial adhesive ability, compared with previous reviews and excellent research papers, but it is not intended to be exhaustive. In particular, we investigated biomaterials for replacement, such as metallic materials (titanium and titanium alloys) and polymers (ultra-high-molecular-weight polyethylene), and biomaterials for regeneration, such as poly(ε-caprolactone) and calcium phosphates as composites. Biomaterials have been designed, developed, and characterized to define surface/bulk features; they have also been subjected to bacterial adhesion assays to verify their potential capability to counteract infections. The addition of metal ions (e.g., silver), natural antimicrobial compounds (e.g., essential oils), or antioxidant agents (e.g., vitamin E) to different biomaterials conferred strong antibacterial properties and anti-adhesive features, improving their capability to counteract prosthetic joint infections and biofilm formation, which are important issues in orthopedic surgery. The complexity of biological materials is still far from being reached by materials science through the development of sophisticated biomaterials. However, close interdisciplinary work by materials scientists, engineers, microbiologists, chemists, physicists, and orthopedic surgeons is indeed necessary to modify the structures of biomaterials in order to achieve implant integration and tissue regeneration while avoiding microbial contamination.
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Cao, Jian, Zhongxing Liu, Limin Zhang, Jinlong Li, Haiming Wang, and Xiuhui Li. "Advance of Electroconductive Hydrogels for Biomedical Applications in Orthopedics." Advances in Materials Science and Engineering 2021 (January 22, 2021): 1–13. http://dx.doi.org/10.1155/2021/6668209.

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Electroconductive hydrogels (EHs) are promising composite biomaterials of hydrogels and conductive electroactive polymers, incorporating bionic physicochemical properties of hydrogels and conductivity, electrochemistry, and electrical stimulation (ES) responsiveness of conductive electroactive polymers. The biomedical domain has increasingly seen EHs’ application to imitating the biological and electrical properties of human tissues, acclaimed as one of the most effective biomaterials. Bone’s complex bioelectrochemical properties and the corresponding stem cell differentiation affected by electrical signal elevate EHs’ application value in repairing and treating bone, cartilage, and skeletal muscle. Noteworthily, the latest orthopedic biological applications require broader information of EHs. Except for presenting the classification and synthesis of EHs, this review recapitulates the advance of EHs application to orthopedics in the past five years and discusses the pertinent development tendency and challenge, aiming to provide a reference for EHs application direction and prospect in orthopedic therapy.
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Balasundaram, Ganesan, and Thomas J. Webster. "Nanotechnology and biomaterials for orthopedic medical applications." Nanomedicine 1, no. 2 (August 2006): 169–76. http://dx.doi.org/10.2217/17435889.1.2.169.

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Aoki, Kaoru, Nobuhide Ogihara, Manabu Tanaka, Hisao Haniu, and Naoto Saito. "Carbon nanotube-based biomaterials for orthopaedic applications." Journal of Materials Chemistry B 8, no. 40 (2020): 9227–38. http://dx.doi.org/10.1039/d0tb01440k.

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Aggarwal, Divyanshu, Vinod Kumar, and Siddharth Sharma. "Drug-loaded biomaterials for orthopedic applications: A review." Journal of Controlled Release 344 (April 2022): 113–33. http://dx.doi.org/10.1016/j.jconrel.2022.02.029.

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Zaokari, Younis, Alicia Persaud, and Amr Ibrahim. "Biomaterials for Adhesion in Orthopedic Applications: A Review." Engineered Regeneration 1 (2020): 51–63. http://dx.doi.org/10.1016/j.engreg.2020.07.002.

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Zaman, Hainol Akbar, Safian Sharif, Mohd Hasbullah Idris, and Anisah Kamarudin. "Metallic Biomaterials for Medical Implant Applications: A Review." Applied Mechanics and Materials 735 (February 2015): 19–25. http://dx.doi.org/10.4028/www.scientific.net/amm.735.19.

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Stainless steel, titanium alloys and cobalt chromium molybdenum alloys are classified under the metallic biomaterials whereby various surgical implants, prosthesis and medical devices are manufactured to replace missing body parts which may be lost through accident, trauma, disease, or congenital conditions. Among these materials, cobalt chromium molybdenum alloys are the common cobalt base alloy used for orthopedic implants due their excellence properties which include high corrosion resistance, high strength, high hardness, high creep resistance, biocompatibility and greater wear resistance. This paper summarises the various aspects and characteristic of metallic biomaterials such as stainless steel, titanium and cobalt chromium alloys for medical applications especially for orthopedic implant. These include material properties, biocompatibility, advantages and limitations for medical implants applications.
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Mödinger, Yvonne, Graciosa Teixeira, Cornelia Neidlinger-Wilke, and Anita Ignatius. "Role of the Complement System in the Response to Orthopedic Biomaterials." International Journal of Molecular Sciences 19, no. 11 (October 27, 2018): 3367. http://dx.doi.org/10.3390/ijms19113367.

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Various synthetic biomaterials are used to replace lost or damaged bone tissue that, more or less successfully, osseointegrate into the bone environment. Almost all biomaterials used in orthopedic medicine activate the host-immune system to a certain degree. The complement system, which is a crucial arm of innate immunity, is rapidly activated by an implanted foreign material into the human body, and it is intensely studied regarding blood-contacting medical devices. In contrast, much less is known regarding the role of the complement system in response to implanted bone biomaterials. However, given the increasing knowledge of the complement regulation of bone homeostasis, regeneration, and inflammation, complement involvement in the immune response following biomaterial implantation into bone appears very likely. Moreover, bone cells can produce complement factors and are target cells of activated complement. Therefore, new bone formation or bone resorption around the implant area might be greatly influenced by the complement system. This review aims to summarize the current knowledge on biomaterial-mediated complement activation, with a focus on materials primarily used in orthopedic medicine. In addition, methods to modify the interactions between the complement system and bone biomaterials are discussed, which might favor osseointegration and improve the functionality of the device.
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R, Nagalakshmi, M. Kalpana, and M. Jeyakanthan. "Development of Hydroxyapatite Coating on Titanium Alloy for Orthopedic Applications." ECS Transactions 107, no. 1 (April 24, 2022): 18647–61. http://dx.doi.org/10.1149/10701.18647ecst.

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Biomaterials are synthetic materials that are utilized to restore or replace damaged or diseased human body parts, allowing them to regain their original form and function to improve the quality and longevity of human life. Titanium and its alloys have long been employed in biomedical applications due to its remarkable features, such as good biocompatibility, resistance to bodily fluid effects, tremendous tensile strength, flexibility, and high corrosion resistance. Titanium and its alloys have a unique combination of strength and biocompatibility that makes them suitable for medical or recreational purposes. If these materials are used as bio-implant, it releases toxic ions like aluminium and vanadium in the body fluid environment after implantation. [1-3] To overcome the problem, Ti6Al4V alloy was coated with hydroxyapatite (HAp), which provides better bioactivity, osteocompatibility, and antibacterial activity. This layer prevents the further passing of ions from the biomaterial and improves the tissue growth on the bone. The present work is to synthesize HAp from snail shells using a simple wet precipitation method.[4] The waste material of snail shells can be utilized for the development of the HAp, which was non-toxic, eco-friendly, and also to improve bioactivity and biocompatibility of the biomaterials. The prepared HAp was coated on the Ti6Al4V alloy by using the electro-deposition method.[5] Thermal analysis of obtained CaO powder was investigated by TG–DTA analysis. The coated alloy was characterized by various techniques such as FTIR, XRD, TG-DTA, FESEM, EDAX, AFM, and antibacterial activity.
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Barros, Joana, Fernando Jorge Monteiro, and Maria Pia Ferraz. "Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections." International Journal of Molecular Sciences 23, no. 19 (October 1, 2022): 11658. http://dx.doi.org/10.3390/ijms231911658.

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One of the most serious complications following the implantation of orthopedic biomaterials is the development of infection. Orthopedic implant-related infections do not only entail clinical problems and patient suffering, but also cause a burden on healthcare care systems. Additionally, the ageing of the world population, in particular in developed countries, has led to an increase in the population above 60 years. This is a significantly vulnerable population segment insofar as biomaterials use is concerned. Implanted materials are highly susceptible to bacterial and fungal colonization and the consequent infection. These microorganisms are often opportunistic, taking advantage of the weakening of the body defenses at the implant surface–tissue interface to attach to tissues or implant surfaces, instigating biofilm formation and subsequent development of infection. The establishment of biofilm leads to tissue destruction, systemic dissemination of the pathogen, and dysfunction of the implant/bone joint, leading to implant failure. Moreover, the contaminated implant can be a reservoir for infection of the surrounding tissue where microorganisms are protected. Therefore, the biofilm increases the pathogenesis of infection since that structure offers protection against host defenses and antimicrobial therapies. Additionally, the rapid emergence of bacterial strains resistant to antibiotics prompted the development of new alternative approaches to prevent and control implant-related infections. Several concepts and approaches have been developed to obtain biomaterials endowed with anti-infective properties. In this review, several anti-infective strategies based on biomaterial engineering are described and discussed in terms of design and fabrication, mechanisms of action, benefits, and drawbacks for preventing and treating orthopaedic biomaterials-related infections.
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Dissertations / Theses on the topic "Biomaterials for orthopedic applications"

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Vidal, Girona Elia. "Development of metallic functionalized biomaterials with low elastic modulus for orthopedic applications." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671888.

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Titanium (Ti) and Ti alloys have been used for decades for bone implants and prostheses due to its mechanical reliability and good biocompatibility. However, implant-related infections, lack of osseointegration with the surrounding bone, and the mismatch of mechanical properties between implant and bone, remain among the leading reasons for implant failure. In the present PhD thesis, two strategies have been studied to increase implant viability: fabrication of porous Ti structures and surface functionalization. The stiffness mismatch between titanium implant and bone can cause significant bone resorption, which can lead to serious complications such as periprosthetic fracture during or after revision surgery. Titanium surface plays a major role in the bone prosthesis interactions, not only to promote initial cell adhesion but also to avoid bacterial adhesion. One strategy studied in the thesis has been the development and manufacturing of porous Ti structures. A scaffold with a porosity of 75% has been prepared by direct ink writing, with the objective of reducing the apparent modulus elasticity of Ti prostheses. In this work, porous Ti structures with a stiffness and compressive strength of 2.6 GPa and 64.5 MPa respectively has been manufactured. To this end, a new ink formulation was designed based on the mixture of a thermosensitive hydrogel with Ti irregular powder particles with a mean particle size of 22.45 μm. A thermal treatment was optimized to ensure the complete elimination of the binder before the sintering process, in order to avoid contamination of the titanium structures. The understanding of infections is closely linked to the concept of the “race for the surface”. The winner of this race (cell versus bacteria) decides if a solid anchoring between implant and bone will be achieved or if bacterial growth will lead to a periprosthetic infection. Another strategy studied on this thesis focuses on the functionalization of the Ti surface. First, surface of Ti scaffolds were functionalized with a cell adhesion fibronectin recombinant fragment for optimizing cell adhesion. Additionally, a multifunctional coating based on the potential of calcium phosphate coatings to be used as carriers for drug delivery was also studied to achieve a balance between cell attachment and reduction of bacterial adhesion. Porous Ti structures have been successfully coated with a one-step pulsed electrodeposition process achieving a uniform calcium phosphate layer both on the inner and outer the surface of the scaffold, with adhesion strengths over 22 MPa. The codeposition of an antibacterial agent with a pulsed and reverse pulsed electrodeposition was achieved on both smooth and open-cell Ti surfaces. The release rate of the antibacterial agent can be modulated within hours or days timeframe by adjusting the coating conditions and without altering the antimicrobial potential of the loaded antibacterial agent itself. The biofunctionalized coatings exhibited a noteworthy in vitro antibacterial activity against S. aureus and E. coli bacteria strains, with a significant decrease of viable attached bacteria to the treated surfaces. Cell culture tests also showed that Ti structures loaded with the antibacterial agent presented an improved cell adhesion compared to that of untreated Ti. Therefore, the proposed strategies can efficiently improve orthopedic implants in terms of improving biointegration and microbial adhesion resistance.
El titani (Ti) i els seus aliatges s'han emprat durant dècades per a implants i pròtesis òssies a causa de la seva fiabilitat mecànica i bona biocompatibilítat. Tanmateix, les infeccions relacionades amb els implants, la manca d'osteointegració amb l'os circumdant i el desajust de les propietats mecàniques entre l'implant i l'os, continuen sent els principals motius de fallida de l'implant En la present tesi doctoral, s'han estudiat dues estratègies per augmentar la viabilitat de l'implant fabricació d'estructures poroses de Ti i funcionalització superficial. El desajust de la rigidesa entre l'implant de titani i l'os pot causar una reabsorció òssia important, que pot provocar complicacions greus com la fractura periprotètica durant o després de la cirurgia de revisió . La superfície del titani té un paper important en les interaccions os-pròtesi, no només per promoure l'adhesió inicial de les cèl·lules, sinó també per evitar l'adhesió bacteriana. Una estratègia estudiada a la tesi ha estat el desenvolupament i fabricació d'estructures poroses de Ti. S'ha preparat un andamiatge amb una porositat del 75% mitjançant Direct lnk Writing, amb l'objectiu de reduir l'elasticitat del mòdul aparent de les pròtesis de Ti. En aquest treball, s'han fabricat estructures poroses de Ti amb una rigidesa i resistència a la compressió de 2,6 GPa i 64,5 MPa respectivament. Per això, es va dissenyar una nova formulació de tinta basada en la barreja d'un hidrogel termosensible amb partícules de pols irregulars de Ti amb una mida mitjana de partícula de 22,45 µm. Es va optimitzar un tractament tèrmic per assegurar l’eliminació completa de l'aglutinant abans del procés de sinterització, per evitar la contaminació de les estructures de titani. La lluita contra les infeccions està estretament lligada al concepte de "carrera per la superfície". El guanyador d'aquesta carrera (cèl·lula contra bacteris) decideix si s'aconseguirà un ancoratge sòlid entre l'implant i l'os o si el creixement bacterià conduirà a una infecció periprotètica. Una altra estratègia estudiada en aquesta tesi se centra en la funcionalització de la superfície de Ti. En primer lloc, la superfície d'andamiatges de Ti es va funcionalitzar amb un fragment recombinant fibronectina d'adhesió cel·lular per optimitzar l’adhesió cel·lular. A més, també es va estudiar un recobriment multifuncional basat en l'ús de recobriments de fosfat de calci com a portadors per a l'alliberament de medicaments per aconseguir un equilibri entre la adhesió cel·lular i la reducció de l'adhesió bacteriana. Les estructures poroses de Ti s'han recobert amb èxit amb un procés d'electrodeposició polsada d'un pas, aconseguint una capa uniforme de fosfat de calci tant a la superfície interna com exterior de les estructures, amb resistències d’adhesió superiors a 22 MPa. La co-deposició d'un agent antibacterià amb una electrodeposició polsada i polsada inversa es va aconseguir tant a les superfícies de Ti d'estructura oberta coma les llises. La velocitat de l'agent antibacterià es pot modular en un terminí d'hores o dies ajustant les condicions de recobriment i sense alterar el potencial antimicrobià del propi agent antibacterià carregat. Els recobriments biofuncionalitzats van mostrar una notable activitat antibacteriana in vitro contra les soques de bacteris S. aureus i E. coli, amb una disminució significativa de bacteris adherits viables a les superfícies tractades. Les proves de cultiu cel·lular també van demostrar que les estructures de Ti carregades de l'agent antimicrobià presentaven una millor adhesió cel·lular en comparació amb la Ti no tractat. Per tant. les estratègies proposades poden millorar els implants ortopèdics de manera eficient en termes de millora de la biointegració la resistència a l'adherència microbiana.
Ciència i enginyeria de materials
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Clem, William Charles. "Mesenchymal stem cell interaction with nanonstructured biomaterials for orthopaedic applications." Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/clem.pdf.

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Thesis (Ph. D.)--University of Alabama at Birmingham, 2008.
Additional advisors: Yogesh K. Vohra, Xu Feng, Jack E. Lemons, Timothy M. Wick. Description based on contents viewed July 8, 2009; title from PDF t.p. Includes bibliographical references.
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Smith, Michael E. "Method Development for On-Site Air Quality Analysis and Design of Hydrogen Sensors for Orthopedic Applications." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1583999801696302.

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Raghuraman, Kapil. "Synthesis and Evaluation of a Zn-Bioactive Glass Series to Prevent Post-Operative Infections in Craniofacial Applications." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525241500626456.

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Ahn, Edward Sun 1972. "Nanostructured apatites as orthopedic biomaterials." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8627.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2001.
Includes bibliographical references.
Historically, using suitable mechanical replacements for bone has been a priority in designing permanent, load-bearing orthopedic implants. As a result, the biomaterials used in these implants have been largely limited to bioinert titanium-based alloys, as well as to polycrystalline alumina and zirconia ceramics. However, analysis of implants incorporating these traditional biomaterials indicated that most failures involved an unstable implant-tissue interface and/or a mismatch of the mechanical behavior of the implant with the surrounding tissues. As a result, up to 20% of patients receiving permanent, load-bearing implants may undergo a revision operation. The objective of this research was to develop an alternative biomaterial that combined both mechanical resilience and an osteoconductive surface to provide a stable interface with the surrounding connective tissue so that the need for revision operations may be significantly reduced. In the effort to address the issue of mechanical strength and bioactivity simultaneously, hydroxyapatite (HAP) has generated considerable interest. Though a commonly used bioceramic, HAP has been limited by its processability. This material is sensitive to non-stoichiometry and impurities during synthesis and processing due to its complex composition and crystal structure (Ca10(P04)6(OH)2, P63/m).
(cont.) Consequently, conventionally processed HAP materials lack phase purity and homogeneity. Densification of HAP requires high temperatures that result in grain growth and decomposition into undesired phases with poor mechanical and chemical stability. To circumvent densification at high temperatures, glassy additives have been introduced to promote liquid-phase sintering at a lower temperature. However, the presence of a secondary glassy phase gave rise to poor mechanical characteristics. Hence, clinical applications of HAP have been limited to powders, coatings, porous bodies, and non-load-bearing implants. To overcome the deficiencies of conventionally processed HAP, nanostructure processing was applied, which allowed for materials design from the molecular level. By using an aqueous chemical precipitation technique, a fully dense, transparent, nanostructured HAP-based bioceramic that exhibited superior mechanical properties and enhanced tissue bonding was obtained. Processing parameters affecting the molecular and structural development of HAP were used to tailor HAP stoichiometry, crystallite size, morphology and surface chemistry for optimal thermal stability and sinterability. Unlike conventionally processed HAP, the stoichiometric, equiaxed, nanocrystalline HAP powders demonstrated significantly enhanced sinterability by fully densifying at a remarkably low temperature of 900ʻC with pressure-assisted sintering.
(cont.) Furthermore, high-resolution electron micrographs illustrated that the sintered compact possessed a uniform and ultrafine microstructure with an average grain size of -100 nm, with no glassy or amorphous interfaces along the grain boundaries. The crystallinity of the HAP grains and grain boundaries and the minimal flaw sizes could be credited for the superior strength of nanostructured HAP compared to conventional HAP. Compared to polycrystalline HAP, nanocrystalline HAP also provided greater osteoblast function. In vitro experiments indicated that nanocrystalline HAP surfaces enhanced cell attachment, proliferation and mineralization. The larger grain boundary volume resulting from the ultrafine microstructure might have enhanced protein adsorption, ...
by Edward Sun Ahn.
Ph.D.
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Devlin, Sean M. "Improving Degradable Biomaterials for Orthopedic Fixation Devices." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/394989.

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Bioengineering
Ph.D.
Current degradable orthopedic fixation devices do not typically facilitate tissue integration during healing. Proposed here is a novel combination of processing methods to enhance the tissue integration capability of degradable thermoplastics used in temporary orthopedic fixation devices. The provision of open pores in devices used to affix reconstructed hard tissues would allow for local cells to infiltrate during the healing process. Any openly porous structure is inherently weakened in comparison to its monolithic peers (i.e. decreased relative bulk modulus), such that the matrix materials must be made more resilient in keep the device from becoming friable. These processing methods aim to improve degradable surgical fixation devices at multiple levels of design: both through the inclusion of porous morphology, processing changes, and additives to regain mechanical integrity. Biomimetic pores are added for cellular infiltration by dissolving a porogen’s interpenetrating polymer network. The addition of open pores significantly reduces the bulk stiffness. More uniform phase separation has led to better pores, but the objects still need more resilience. Carbon nanomaterials are used to improve on the mechanics and surface chemistry of the polymer matrix material, composites of polylactide/nanodiamond are produced through cryogenic milling and solid state polycondensation. The addition of minute amounts of functionalized nanodiamond has remedied the brittle failure of the material, by cryogenic milling and solid state polycondensation of poly((D,L)lactide-co-glycolide) and hydroxyl functionalized detonation nanodiamonds. This composite has also demonstrated increased cytocompatability with 7F2 osteoblasts, as analyzed by cellular adhesion through fluorescence microscopy and alamar blue assay.
Temple University--Theses
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Ensing, Geert Tone. "Prevention and treatment of biomaterial related infection in orthopedics a study of application of ultrasound and of antibiotic release /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/291344038.

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Gianforcaro, Anthony L. "Improvement Of Biodegradable Biomaterials For Use In Orthopedic Fixation Devices." Master's thesis, Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/599834.

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Bioengineering
M.S.
Current orthopedic internal fixation devices, such as pins and screws, are typically made from metals and have a long list of complications associated with them. Most notably, complications such as infection or decreased wound healing arise from revisional surgeries needed to remove the used hardware. A new class of fixation devices is being produced from biodegradable biomaterials to eliminate the need for revisional surgery by being naturally broken down in the body. While currently available polymers lack the necessary mechanical properties to match bone strength, the incorporation of small amounts of hydroxylated nanodiamonds has been proven to increase the mechanical properties of the native polymer to better resemble native bone. Additionally, modern polymers used in biodegradable fixation devices have degradation rates that are too slow to match the growth of new bone. Poly-(D, L)-lactic-co-glycolic acid (PDLG) incorporated with hydroxylated nanodiamonds has not only been proven to start out stronger, but then also helps the polymer degrade faster when compared to the pure polymer in vivo and prevents effusion of the polymer into the surrounding environment. Nanodiamond incorporation is accomplished via solid state polycondensation of PDLG to create a uniform material with increased mechanical properties, faster degradation rates, and enhanced calcification when tested in simulated body fluid.
Temple University--Theses
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Wong, Kai-lun, and 黄棨麟. "Strontium-substituted hydroxyapatite reinforced polyetheretherketone biomaterials in orthopaedic implants." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42182505.

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Wong, Kai-lun. "Strontium-substituted hydroxyapatite reinforced polyetheretherketone biomaterials in orthopaedic implants." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42182505.

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Books on the topic "Biomaterials for orthopedic applications"

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Kim, Kyo-Han. Surface modification of titanium for biomaterial applications. Hauppauge, N.Y: Nova Science Publishers, 2009.

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(Ramaswamy), Narayanan R., and Rautray Tapash R, eds. Surface modification of titanium for biomaterial applications. New York: Nova Science Publishers, 2010.

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Li, Bingyun, and Thomas Webster, eds. Orthopedic Biomaterials. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89542-0.

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Li, Bingyun, and Thomas Webster, eds. Orthopedic Biomaterials. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73664-8.

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Inc, Medical Data International. U.S. markets for orthopedic biomaterials. Santa Ana, Calif. (5 Hutton Centre Dr. Suite 1100, 92707): Medical Data International, 2000.

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Ravi, Prakash, and International Symposium on Biomaterials in Orthopaedics (1989 : Institute of Technology, Banaras Hindu University), eds. Biomaterials in orthopaedics. Varanasi, India: School of Biomedical Engineering, Institute of Technology, Banaras Hindu University, 1990.

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Wise, Donald L., Debra J. Trantolo, David E. Altobelli, Michael J. Yaszemski, and Joseph D. Gresser, eds. Human Biomaterials Applications. Totowa, NJ: Humana Press, 1996. http://dx.doi.org/10.1007/978-1-4757-2487-5.

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1937-, Wise Donald L., ed. Human biomaterials applications. Totowa, NJ: Humana Press, 1996.

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Biomaterials for bone regenerative medicine. Stafa-Zuerich: Trans Tech, 2010.

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J, Yaszemski Michael, ed. Biomaterials in orthopedics. New York: M. Dekker, 2004.

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Book chapters on the topic "Biomaterials for orthopedic applications"

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Hickey, Dan, and Thomas Webster. "Nanotechnology for Orthopedic Applications: From Manufacturing Processes to Clinical Applications." In Orthopedic Biomaterials, 3–20. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89542-0_1.

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de Guzman, Roche C. "Materials for Orthopedic Applications." In Orthopedic Biomaterials, 367–98. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73664-8_14.

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Yang, Ke, Lili Tan, Peng Wan, Xiaoming Yu, and Zheng Ma. "Biodegradable Metals for Orthopedic Applications." In Orthopedic Biomaterials, 275–309. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73664-8_11.

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Nath, Shekhar, and Bikramjit Basu. "Materials for Orthopedic Applications." In Advanced Biomaterials, 53–100. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470891315.ch3.

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Kang, Jason, Krystal Hughes, Malcolm Xing, and Bingyun Li. "Orthopedic Applications of Silver and Silver Nanoparticles." In Orthopedic Biomaterials, 63–83. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73664-8_3.

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Nijsure, Madhura P., and Vipuil Kishore. "Collagen-Based Scaffolds for Bone Tissue Engineering Applications." In Orthopedic Biomaterials, 187–224. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73664-8_8.

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Prabhu, Balaji, Andreas Karau, Andrew Wood, Mahrokh Dadsetan, Harald Liedtke, and Todd DeWitt. "Bioresorbable Materials for Orthopedic Applications (Lactide and Glycolide Based)." In Orthopedic Biomaterials, 287–344. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89542-0_13.

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Yang, Jingzhou. "Progress of Bioceramic and Bioglass Bone Scaffolds for Load-Bearing Applications." In Orthopedic Biomaterials, 453–86. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89542-0_18.

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Kankilic, Berna, Eda Ciftci Dede, Petek Korkusuz, Muharrem Timuçin, and Feza Korkusuz. "Apatites for Orthopedic Applications." In Clinical Applications of Biomaterials, 65–90. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56059-5_3.

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Johnson, Ian, Jiajia Lin, and Huinan Liu. "Surface Modification and Coatings for Controlling the Degradation and Bioactivity of Magnesium Alloys for Medical Applications." In Orthopedic Biomaterials, 331–63. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73664-8_13.

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Conference papers on the topic "Biomaterials for orthopedic applications"

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Gong, Haibo, Antonios Kontsos, Yoontae Kim, Peter I. Lelkes, Qingwei Zhang, Donggang Yao, Kavan Hazeli, and Jack G. Zhou. "Micro Characterization of Mg and Mg Alloy for Biodegradable Orthopedic Implants Application." In ASME 2012 International Manufacturing Science and Engineering Conference collocated with the 40th North American Manufacturing Research Conference and in participation with the International Conference on Tribology Materials and Processing. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/msec2012-7395.

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Magnesium as a candidate metallic biomaterial for biodegradable orthopedic implants was evaluated in-vitro in terms of degradation behavior, biocompatibility and mechanical property both in macro- and micro-scale. Micro structure of pure Mg and AZ61 after degradation in both simulated body fluid (SBF) and cell culture environment were analyzed. Different from AZ61, pure Mg degraded at a higher rate and attracted large amount of salt precipitation which formed a layer covering the surface. Much less pitting degradation and salt deposition were observed on both pure Mg and AZ61 in cell culture environment compared to in SBF. After culturing for 7 days, EAhy926 cells growing on AZ61 showed significant higher proliferation rate as of cells growing on pure Mg. Higher proliferation rates indicated that cells grew better on slow-degrading AZ61 than on fast-degrading pure Mg. Cells growing on AZ61 proliferated much better and assembled together to form a consistent tissue-like micro-structure, while cells spread and reached out on the surface of pure Mg, possibly due to low cell density and lack of cellular communication. The elastic modulus and tensile yield strength of magnesium are closer to those of natural bone than other commonly used metallic biomaterials. It was shown that Mg was biodegradable, biocompatible and had appropriate mechanical strength, thus Mg and its alloys showed great potential for deployment in a new generation of biodegradable orthopedic implants.
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Mahmoud, Rahmatul, Quang Nguyen, Gordon Christopher, and Paul F. Egan. "3D Printed Food Design and Fabrication Approach for Manufacturability, Rheology, and Nutrition Trade-Offs." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-70663.

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Abstract 3D printing enables the production of personalized designs that are desirable in the medical industry for applications including orthopedics, tissue engineering, and personalized nutrition. Currently, the design process relies on trial-and-error approaches, especially for biomaterial development, and there is a need for methodologies to streamline the design process to facilitate automation. Here, we investigate a design methodology for printing foods by mixing novel biomaterial combinations informed by rheological measurements that indicate printability. The process consists of first printing basic designs with chocolate, marzipan, and potato biomaterials known to print consistently. Rheological measurements are collected for these materials and compared to a novel pumpkin biomaterial. The pumpkin had a higher complex modulus and lower mechanical loss tangent than all other biomaterials, therefore motivating the addition of rheological agents to reach more favorable properties. Varied concentrations of corn starch and guar gum were added to the pumpkin to improve printability while altering the nutrient distribution. A 4% inclusion of guar gum provided the most consistent pumpkin prints. A complex 3D object was fabricated with the 4% guar gum pumpkin material, therefore demonstrating the merits in using rheological properties to inform printability for use in design automation routines. The design approach enabled comparisons of relative nutrition and printability trade-offs to demonstrate a proof-of-concept user interface for design automation to facilitate customized food production. Further research to develop a complete design methodology for linking rheological properties to printability would promote consistent prediction of print quality for novel formulations to support design automation, with potential generalizability for diverse biomaterials.
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Salahshoor, M., and Y. B. Guo. "Machining Characteristics of High Speed Dry Milling of Biodegradable Magnesium-Calcium Alloy." In ASME 2010 International Manufacturing Science and Engineering Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/msec2010-34310.

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Metallic degradable biomaterials have attracted a huge attention lately for orthopedic fixation applications. Binary magnesium and calcium (Mg-Ca) alloys have emerged as a promising choice in terms of biocompatibility to avoid stress shielding and provide sufficient mechanical strength. In this paper, efficient and ecologic machining of a lab-made Mg-Ca alloy with 0.8 wt% calcium, cutting speeds of up to 47 m/s, and without coolant are investigated. Polycrystalline diamond inserts are applied and the possibilities of flank built-up formation, chip ignition, and tool wear are sought during the cutting experiments with the aid of a developed on-line, optical monitoring system. Chip morphology characteristics produced by different combinations of cutting parameters, i.e. cutting speed, feed, and depth of cut are studied.
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Iskandar, Maria E., Jaclyn Y. Lock, Arash Aslani, and Huinan Liu. "Controlling the Biodegradation of Magnesium Implants Through Nanostructured Coatings." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65901.

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Magnesium (Mg) alloys, a novel class of degradable, metallic biomaterials, have attracted growing interest as a promising alternative for medical implant and device applications due to their advantageous mechanical and biological properties. Moreover, magnesium is biodegradable in the physiological environments. The major obstacle for Mg to be used as medical implants is its rapid degradation in physiological fluids. Therefore, the present key challenge lies in controlling Mg degradation rate in the physiological environment. The objective of this study is to develop a nanostructured-hydroxyapatite (nHA) coating on Mg implants to control the degradation and bone tissue integration of the implants. Nanostructured-HA coatings are deposited on magnesium using the Spire’s patented TPA process to moderate the aggressive degradation of magnesium and to improve fast osteointegration between magnesium and natural bone. Morphology and element compositions were characterized using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) analysis. The degradation of nHA coated Mg and uncoated Mg was investigated by incubating samples in phosphate buffered saline (PBS) under standard cell culture conditions. The degradation results suggest the nanocoatings positively mediated magnesium degradation. Therefore, nHA coatings are promising for controlling the biodegradation of magnesium-based orthopedic implants and devices.
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Sivarasu, Sudesh, Sam Prasanna James, and T. Lazar Mathew. "Finite Element Method Oriented Failure Analysis of Medical Implants: Artificial Knee." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16145.

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The application of Finite Element Modelling in Medical Applications has been evolving as the field of high importance especially in the development of medical devices. The Total Knee Arthroplasty [TKA] has been in existence for over 6 decades till now. The generic artificial knee implants used in the TKA have the restriction in its range of motion with around 90 degrees. A new design allowing flexion extension range of over 120 degrees was designed with a view to facilitate partial squatting and the same is used for the analysis purpose. The new design of the artificial knee has a flexion extension range of 130 degrees. The higher flexion of the knee is obtained by use of the rotating platform knee design principle and also by adopting a multi-radii approach for the femoral component design. The loading conditions of 10 times the body weight are considered for structural analyses of the novel knee. A maximum load of 700Kg were subjected on the knee implants. The finite element analyses of the designs were carried out based on standard biomaterial used in orthopedic implants. In this paper we have discussed the results of analyses of an artificial knee with Ti alloy. The results of the analyses were used in identifying areas of extreme stresses within the design and the spot prone for higher deformation. Based on these results slight modification on the designs was carried out. The results are also verified whether the body is within the linear deformation levels. As the results obtained were very satisfactory the models have been recommended for prototyping.
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Salahshoor, M., and Y. B. Guo. "Surface Integrity of Biodegradable Magnesium-Calcium (Mg-Ca) Alloy by Low Plasticity Burnishing." In STLE/ASME 2010 International Joint Tribology Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ijtc2010-41214.

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When a device is implanted into the body, into either hard or soft tissue, the body will respond. While the bulk material of the device is often important for integrity and mechanical success, the device surface is at the interface with biology. Major effort has been spent modifying a biomaterial surface in order to elicit or inhibit a biological response. Metallic biodegradable Magnesium-Calcium (Mg-Ca) alloys have attracted an increased attention for orthopedic fixation applications. This research focuses on low plasticity burnishing (LPB) as a novel surface modification technique that is added to the surface to control biodegradation as a biological response. The effects of burnishing pressure as an important process parameter on surface integrity characteristics such as surface roughness, surface topography, and residual stresses are investigated. Burnished surface roughness is smaller than the machined ones. However, some amount of waviness is observed which might be due to large diameter of the burnishing ball and sever plastic deformation. High compressive residual stresses are measured on the burnished surface.
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Salahshoor, M., and Y. B. Guo. "Surface Integrity of Magnesum-Calcium Orthopedic Biomaterial Procesed by Dry High-Speed Face Milling." In ASME 2010 5th Frontiers in Biomedical Devices Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/biomed2010-32062.

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Biodegradable magnesium-calcium (Mg-Ca) implants have the ability to gradually dissolve and absorb into the human body after implantation. The critical issue that hinders the application of Mg-Ca implants is its poor corrosion resistance to human body fluids. A promising approach to tackle this issue is tailoring the surface integrity characteristics of the orthopedic implants to get an appropriate corrosion kinetic. High speed face milling of biodegradable Mg-Ca alloy is used in this study as a possible way to achieve that goal. Polycrystalline diamond inserts are used to avoid material adhesion and likely fire hazards. All the cutting tests are performed without using coolant to keep the manufacturing process ecological. High cutting speed of 40 m/s and 200 μm depth of cut are applied in a broad range of feed values to cover finish and rough cutting regimes. The effect of feed as a key machining parameter which defines the amount and duration of thermo-mechanical load and ultimately provides higher chances for surface integrity changes are investigated.
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Weng, L., D. A. Stout, and T. J. Webster. "Nanophase magnesium for orthopedic applications." In 2012 38th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2012. http://dx.doi.org/10.1109/nebc.2012.6207047.

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Sharma, Anu, and Gayatri Sharma. "Biomaterials and their applications." In 2ND INTERNATIONAL CONFERENCE ON CONDENSED MATTER AND APPLIED PHYSICS (ICC 2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5032847.

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Puckett, Sabrina, Jing Lu, and Thomas Webster. "Nano patterned titanium for orthopedic applications." In 2007 IEEE 33rd Annual Northeast Bioengineering Conference. IEEE, 2007. http://dx.doi.org/10.1109/nebc.2007.4413356.

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