Dissertations / Theses on the topic 'Biomaterials Fabrication'
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Dougherty, Shelley A. "Template-assisted fabrication of nano-biomaterials." Digital WPI, 2009. https://digitalcommons.wpi.edu/etd-dissertations/351.
Full textHuadmai, Jerawala. "A novel processing route for the fabrication of porous magnesium biomaterials." Thesis, University of Canterbury. Engineering, 2005. http://hdl.handle.net/10092/6460.
Full textMayor, Elizabeth Laura. "Fabrication and Characterization of Electrospun Poly-Caprolactone-Gelatin Composite Cuffs for Tissue Engineered Blood Vessels." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-theses/512.
Full textGrey, Casey. "Tissue Engineering Scaffold Fabrication and Processing Techniques to Improve Cellular Infiltration." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3652.
Full textCoffigniez, Marion. "Additive manufacturing of 3D architectured metallic biomaterials by robocasting." Thesis, Lyon, 2021. http://www.theses.fr/2021LYSEI007.
Full textBeyond the personalisation aspect that it can bring to the medical field, additive manufacturing also gives access to the elaboration of cellular structures. These structures, with controlled porosity, make it possible both to modulate the mechanical properties of the object and to promote the cellular invasion necessary in tissue engineering. Among the metals commonly used in orthopaedic surgery, titanium alloys are those with the rigidity least distant from that of bone. This study therefore focuses on the development of structures made of Ti6-Al-4V, but also of magnesium since it has the advantage of being resorbable in the body. The scaffolds are obtained by robocasting, a process consisting of extruding, layer by layer, a pasty ink made up of powder and binder. The structures have then to be debinded and sintered at high temperature to achieve their final properties. For Ti-6Al-4V structures, a parametric study is carried out to evaluate the possibilities and limits of the process in terms of structures (and microstructures), chemical compositions and mechanical properties obtained. After optimisation, it is possible to obtain parts with two levels of interconnected porosities (intra-filament (interconnected) microporosity, beneficial for cell adhesion according to the literature, and drawn macropores), keeping a specific yield strength higher than that of bone (105 MPa.cm³/g) and a Young's modulus close to that of bone (28-30 GPa). An intra-filament porosity gradient can also be obtained by varying the powder size within a single part. Concerning magnesium, a binder compatible with the reactivity of the powder (ethanol base) has been identified and the first steps of the process (printing, debinding) are therefore quite feasible for this material. However, conventional sintering of (pure) magnesium is complicated by its reactivity. Alternative sintering methods are therefore being investigated (liquid phase sintering, Spark Plasma Sintering)
Janakiraman, Vijayakumar. "DESIGN, FABRICATION AND CHARACTERIZATION OF BIFURCATING MICROFLUIDIC NETWORKS FOR TISSUE-ENGINEERED PRODUCTS WITH BUILT-IN MICROVASCULATURE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196457966.
Full textTu, Xiaolong. "Fabrication et étude de scaffolds multidimensionnels pour l'ingénierie cellulaire et tissulaire." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEE045/document.
Full textThe objective of this work is to develop a method of engineering multi-dimensional scaffolds for cell culture and tissue formation. We firstly applied a 3D printing technique to produce the designed frame in PEGDA and then filled the free-space of the frame with a gelatin gel. After freezing and drying, a hybrid 3D scaffold made of gelatin porous structures and PEDGA backbone was obtained, which supported culture and differentiation of neural progenitor cells. To more easily integrate into a microfluidic device, we also designed a 2D scaffold in form of a thin layer of honeycomb frame of PEGDA and self-assembled porous structure of PCL. Such a patch form scaffold could be used for cell culture and gene transfection, showing advantages over the conventional methods in terms of nutrients and soluble factors uptake. Finally, we fabricated a soft patch made of an elastic frame in PDMS and a monolayer of gelatin nanofibers to facilitate cardiac differentiation from human induced pluripotent stem cells. As expected, we achieved a cardiac generation with higher contraction strength and a higher beating homogeneity comparing to the conventional approaches. All together, we demonstrated the utility of hybrid scaffolds for micro-tissue engineering which could impact the future studies in the fields of tissue engineering, drug screening and regenerative medicine
Petet, Thomas J. Jr. "Characterization of Poly(dimethylsiloxane) Blends and Fabrication of Soft Micropillar Arrays for Force Detection." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4649.
Full textJames, Colby M. "Assessment of electrospinning as an in-house fabrication technique for blood vessel mimic cellular scaffolding." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/185.
Full textPal, Ramendra K. "Fabrication of flexible, biofunctional architectures from silk proteins." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4995.
Full textSeregin, Vladimir Victor. "Part I, Fabrication and surface modification of composite biomaterials based on silicon and calcium disilicide Part II, Synthesis and characterization of erbium doped silicon nanocrystals encapsulated by aluminum and zinc oxides /." Fort Worth, Tex. : Texas Christian University, 2006. http://etd.tcu.edu/etdfiles/available/etd-04252006-145309/unrestricted/seregin.pdf.
Full textGuduru, Rakesh. "Bionano Electronics: Magneto-Electric Nanoparticles for Drug Delivery, Brain Stimulation and Imaging Applications." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/979.
Full textKelly, Jennifer Yvonne DeSimone Joseph M. "Novel fluoroelastomers composed of tetrafluoroethylene and vinylidene fluoride oligomers synthesized in carbon dioxide for use in soft lithography to enable a platform for the fabrication of shape- and size-specific, monodisperse biomaterials." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1934.
Full textTitle from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.
Toledo, Dennis. "Cobalt Ferrite Nanoparticles Fabricated via Co-precipitation in Air: Overview of Size Control and Magnetic Properties." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2298.
Full textLavielle, Nicolas. "Fabrication de nanofibres et nanoparticules de biopolyesters pour la libération contrôlée d'un composé modèle." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01063059.
Full textYang, Luyuan. "Fabrication of ultrathin films from regenerated silk fibroin solution for biomaterial applications." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/fabrication-of-ultrathin-films-from-regenerated-silk-fibroin-solution-for-biomaterial-applications(49e95f65-30d7-44d2-8b70-8e1f164c0137).html.
Full textKang, Byoung Sam. "Fabrication and characterization of compound semiconductor sensors for pressure, gas, chemical, and biomaterial sensing." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0012990.
Full textQiu, Weiguo. "Fabrication and Characterization of Recombinant Silk-elastinlike Protein Fibers for Tissue Engineering Applications." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/201490.
Full textSosale, Ganesh. "AUTOMATING THE PROCESS OF FABRICATING UNIFORM-SIZED CELL SPHEROIDS FOR THREE-DIMENSIONAL BIOPRINTING." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3956.
Full textKhadka, Dhan Bahadur. "Fabricating and Characterizing Physical Properties of Electrospun Polypeptide-based Nanofibers." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4707.
Full textXie, Sibai. "Characterization and Fabrication of Scaffold Materials for Tissue Engineering." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1366303111.
Full textNatesan, Pooja Vardhini. "Fabrication and characterization of polycaprolactone/graphene oxide electrospun scaffolds for tissue engineering applications." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17129.
Full textA recente evolução científica no campo da engenharia de tecidos (TE) criou oportunidades únicas para fabricar tecidos de substituição de órgãos artificiais em laboratório a partir de combinações de matrizes extracelulares (andaimes), células e moléculas biologicamente ativas. adicionalmente, a formulação de compósitos poliméricos reforçados com cargas nanométricas como o óxido de grafeno (GO) mostrou ser possível uma grande melhoria de várias propriedades destes compósitos em relação aos polímeros simples. No presente estudo, matrizes fibrosas de policaprolactona (PCL) e de PCL-GO foram preparadas através de eletrofiação sob diferentes condições. Foi analisado o efeito de vários parâmetros de electrofiação tais como, peso molecular do polímero, solventes, concentração, caudal, tensão e distância de trabalho, sobre a morfologia das fibras eletrofiado. A incorporação de GO nas fibras de PCL alterou a morfologia, química de superfície e as propriedades mecânicas das fibras de PCL compósitos, o que foi comprovado por meio de várias técnicas de caracterização. As matrizes fibrosas de PCL-GO com a concentração de GO de 0,1% em peso demonstraram ser a combinação mais interessante para estudos futuros em TE.
Scientific advancements in the field of tissue engineering (TE) have created unique opportunities to fabricate artificial tissue or organ replacement components in the laboratory from combinations of engineered extracellular matrices (scaffolds), cells and biologically active molecules. Polymer composites reinforced with nanosized graphene oxide (GO) fillers have shown large improvement of various properties over the pristine polymers. In the present study, polycaprolactone (PCL) and PCL-GO fibres were prepared through electrospinning under different conditions. The effect of several electrospinning parameters (polymer molecular weight, solvent system, concentration, flow rate, voltage and working distance) on the morphology of the electrospun fibres was investigated. The GO nanosheets were successfully incorporated into the PCL fibres and the changes in the morphology, surface chemistry and mechanical properties were analyzed through various characterization techniques. The PCL-GO electrospun fibres with GO concentration of 0.1 wt% was found to be the most attractive combination which can be utilized for future TE applications.
Caves, Jeffrey Morris. "Architecturally defined scaffolds from synthetic collagen and elastin analogues for the fabrication of bioengineered tissues." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31731.
Full textCommittee Chair: Elliot L. Chaikof; Committee Member: Ajit Yoganathan; Committee Member: Larry McIntire; Committee Member: Marc Levenston; Committee Member: Mark Allen. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Jahadakbar, Ahmadreza. "The Additively Manufactured Porous NiTi and Ti-6Al-4V in Mandibular Reconstruction: Introducing the Stiffness-Matched and the Variable Stiffness Options for the Reconstruction Plates." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470321666.
Full textJalal, Ahmed Hasnain. "Multivariate Analysis for the Quantification of Transdermal Volatile Organic Compounds in Humans by Proton Exchange Membrane Fuel Cell System." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3886.
Full textPhilip, Merene. "Fabrication and Characterization of Poly(2-Hydroxyethyl Methacrylate) Microparticle Sensors." Thesis, 2013. http://hdl.handle.net/1969.1/149293.
Full text"Fused Filament Fabrication of Prosthetic Components for Trans-Humeral Upper Limb Prosthetics." Doctoral diss., 2017. http://hdl.handle.net/2286/R.I.45939.
Full textDissertation/Thesis
Doctoral Dissertation Biomedical Engineering 2017
(6623510), Reaz Chowdhury. "ROLL-TO-ROLL FABRICATION OF CELLULOSE NANOCRYSTAL NANOCOMPOSITE FOR GAS BARRIER AND THERMAL MANAGEMENT APPLICATIONS." Thesis, 2019.
Find full textCellulose nanocrystals (CNCs) and its composite coatings may impart many benefits in packaging, electronic, optical, etc. applications; however, large-scale coating production is a major engineering challenge. To fill this knowledge gap, a potential large-scale manufacturing technique, roll-to-roll reverse gravure processing, has been described in this work for the manufacture of CNC and CNC-poly(vinyl alcohol) (PVA) coatings on a flexible polymer substrate. Various processing parameters which control the coating structure and properties were examined. The most important parameters in controlling liquid transfers were gravure roll, gravure speed, substrate speed, and ink viscosity. After successful fabrication, coating adhesion was investigated with a crosshatch adhesion test. The surface roughness and morphology of the coating samples were characterized by atomic force microscopy and optical profilometer. The Hermans order parameter (S) and coating transparency were measured by UV–Vis spectroscopy. The effect of viscosity on CNC alignment was explained by the variation of shear rate, which was controlled by the micro-gravure rotation. Finally, the CNC alignment effect was investigated for gas barrier and thermal management applications.
In packaging applications, cellulose nanomaterials may impart enhanced gas barrier performance due to their high crystallinity and polarity. In this work, low to superior gas barrier pristine nanocellulose films were produced using a shear-coating technique to obtain a range of anisotropic films. Induction of anisotropy in a nanocellulose film can control the overall free volume of the system which effectively controls the gas diffusion path and hence, controlled anisotropy results in tunable barrier properties. The highest anisotropy materials showed a maximum of 900-fold oxygen barrier improvement compared to the isotropic arrangement of nanocellulose film. The Bharadwaj model of nanocomposite permeability was modified for pure nanoparticles, and the CNC data were fitted with good agreement. Overall, the oxygen barrier performance of anisotropic nanocellulose films was 97 and 27 times better than traditional barrier materials such as biaxially oriented poly(ethylene terephthalate) (BoPET) and ethylene vinyl alcohol copolymer (EVOH), respectively, and thus could be utilized for oxygen-sensitive packaging applications.
The in-plane thermal conductivity of CNC - PVA composite films containing different PVA molecular weights, CNC loadings and varying order parameters (S) were investigated for potential application in thermal management of flexible electronics. Isotropic CNC - PVA bulk films with 10-50 wt% PVA solid loading showed significant improvement in thermal conductivity compared to either one component system (PVA or CNC). Furthermore, anisotropic composite films exhibited in-plane thermal conductivity as high as ~ 3.45 W m-1 K-1 in the chain direction, which is higher than most polymeric materials used as substrates for flexible electronics. Such an improvement can be attributed to the inclusion of PVA as well as to a high degree of CNC orientation. The theoretical model was used to study the effect of CNC arrangement (both isotropic and anisotropic configurations) and interfacial thermal resistance on the in-plane thermal conductivity of the CNC-PVA composite films. To demonstrate an application for flexible electronics, thermal images of a concentrated heat source on both neat PVA and CNC-PVA composite films were taken that showed the temperature of the resulting hot spot was lower for the composite films at the same power dissipation."PART I: FABRICATION AND SURFACE MODIFICATION OF COMPOSITE BIOMATERIALS BASED ON SILICON AND CALCIUM DISILICIDE; PART II: SYNTHESIS AND CHARACTERIZATION OF ERBIUM DOPED SILICON NANOCRYSTALS ENCAPSULATED BY ALUMINUM AND ZINC OXIDES." Texas Christian University, 2006. http://etd.tcu.edu/etdfiles/available/etd-04252006-145309/.
Full textRadhakrishnan, Krishna. "Design & Fabrication of Bio-responsive Drug Carriers Based on Protamine & Chondroitin Sulphate Biopolymers." Thesis, 2014. http://etd.iisc.ernet.in/handle/2005/2734.
Full textWang, Yu-chi, and 王羽淇. "A novel PGA-chitosan biomaterial fabrication, modification and biomedical applications." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/68334917199354753338.
Full text國立臺灣大學
化學工程學研究所
91
Abstract In recent years, free tissue transfers, which require tissue or organ substitutes to repair/replace the damaged/diseased organs or tissues have been developed. The immediate problem is the shortage in donor availability. To solve this problem, people use the technology of tissue engineering, which elucidates the structure-function relationships in normal and diseased tissues, to create tissue or organ replacements. Biomaterials play an important role in many of these activities, for example, serving as matrices to guide tissue regeneration, releasing polypeptide growth factors and stimulating cellular response to an antificial implant. This study focused on the development of a novel biomaterial, the modification of the biomaterial, and the application of this novel biomaterial. In the first part, a freeze-fixing method was used to prepare a novel porous PGA-chitosan hybrid matrices (P/C matrices) containing 70% of PGA. The P/C matrices prepared at -20℃ have 100-200 m interconnected micropores in the interior region, with a porous layer present on the bottom and top of the matrices. Another set of the P/C hybrid matrices with freezing temperature at -80℃ were also prepared. The pore size of these matrices is 70-80 m. Fibroblast cells cultured on these P/C matrixes exhibited high viability and maintained spindle morphology, suggesting good biocompatibility for the P/C matrices. It can be concluded that the P/C matrices, due to their high porosity, biocompatibility and degradability, are a promising biomaterial. In the second part, I focus to the surface modification of a biomaterial to enhance its function. The use of wheat germ agglutinin (WGA), a commonly used lectin, covalently bound on to chitosan films to improve the biocompatibility and specificity of chitosan films via oligosaccharide-mediated cell adhesion was examined. After seeding for 12 h, the ratio of live fibroblast cells was about 80% on the WGA-modified chitosan films but at the same time only 65% cells were alive on the control chitosan films. The percentage of live cells on the WGA-modified chitosan films and the chitosan films increased to nearly 100% and 85%, respectively, at 48 h after seeding. The DNA staining revealed that a portion of fibroblasts cultivated on the chitosan films were undergoing apoptosis. In contrast, fibroblasts growing on the WGA-modified chitosan films did not show any indication of apoptosis. Further, the evaluation of the heat shock protein (HSP) mRNA expression in the cells using the reverse transcription-polymerase chain reaction (RT-PCR) method indicated that HSP 90 expression was enhanced on the chitosan films and decreased to normal levels on the WGA-modified chitosan films. Taken together, our data suggest that the use of WGA to enhance the cell-biomaterial interaction is a promising way to achieve appropriate cell adhesion and proliferation, the two key issues in tissue engineering. The third part was to address new applications of this novel P/C biomaterial. Endometriosis, a disease that affects many women in reproductive age, is defined as the presence of endometrial tissue outside its normal location. Although treatment options have improved considerably in recent years, but such as unexplained pelvic problems and infertility still remain. In this study, the growth-inhibitory effect of a novel P/C material-based biological spray on endometriosis was evaluated. Flow cytometry analysis reveled that both fractions of early apoptotic and late apoptotic cells increased in the endometrial cells treated with this P/C spray. This is the first trial using the P/C spray to successfully inhibit cell proliferation by inducing apoptosis. Therefore, this novel P/C spray should have great application potential in endometriosis therapy.
Kascholke, Christian. "Novel Oligomeric Biodegradable Crosslinkers For Hybrid Biomaterial Fabrication For Regenerative Purposes." 2017. https://ul.qucosa.de/id/qucosa%3A21530.
Full textLemos, Isabel Alexandra Fernandes. "Fabrication and characterization of modified macroporous bioceramics for bone regeneration." Doctoral thesis, 2008. http://hdl.handle.net/10216/11252.
Full textLemos, Isabel Alexandra Fernandes. "Fabrication and characterization of modified macroporous bioceramics for bone regeneration." Tese, 2008. http://hdl.handle.net/10216/11252.
Full textChen, GINGER. "Fabrication of a Bioactive Scaffold Material for Meniscus Tissue Engineering." Thesis, 2013. http://hdl.handle.net/1974/8475.
Full textThesis (Master, Chemical Engineering) -- Queen's University, 2013-11-20 15:36:06.12
Venkitachalam, Subramaniam Mukund. "Fabrication of biomaterial scaffolds and in vitro biocampatibility testing with endothelial cells and platelets." 2010. http://digital.library.okstate.edu/etd/Venkitachalam_okstate_0664M_10758.pdf.
Full textHUANG, HAN-SHU, and 黃瀚樞. "Development of a bioprinter for fabricating scaffold of solid fiber using Polymer biomaterial solution." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/3sr267.
Full text國立臺北科技大學
製造科技研究所
107
Low-temperature deposition manufacturing(LDM) is only one method of bioprinting that fabricates bioscaffold using Polymer biomaterial solution. LDM technology's feature is its pore structures of scaffolds, which is advantageous in cell culture. Unfortunately, the feature declines mechanical properties of the scaffolds. LDM technology is not suitable for fabricating scaffolds of higher mechanical strength requirements. Therefore, the Development of a bioprinter for fabricating bioscaffold of solid fiber using Polymer biomaterial solution will be proposed in this research. The process fabricates bioscaffolds with solid fiber; through the process of which solvent evaporation reduces the volume of the material. The system proposed consists of four modules which allows the produced objects a maximum build volume of 200mm×200mm×100mm. The first module is in charge of moving the nozzle in the XYZ direction, while the second and third controls the temperature of the material and build platform, respectively. The last module adjusts the airflow that controls the evaporation of the solvent of material. Finally, diverse 3D models with different structures were fabricated in order to inspect the performance of the bioprinter.
Li, Ying, and 李穎. "Fabrication and characterization of biomolecules composites for design and development of biomaterial devices, biosensors and energy applications." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/f2baf2.
Full text國立臺北科技大學
工程科技研究所
101
The thesis work proposes was to synthesize novel nanomaterials like graphene, carbon nanotubes based biomolecules for application in fabrication of biosensors, biofuel cells and solar cells. The research includes the synthesis of carbon based nanocomposite and their different morphologies, biosynthesis of nanomaterials, bioelectrode modification, characterization of biomolecules modified electrodes, and their applications. The research focus will be mainly in selection of various suitable compounds/biomolecules for carbon nanotubes, Fullerene, graphene based on nanocomposite, and other morphology composites, and their characterization. The main work is the application for the prepared nanocomposite for electrode modification. The modified electrodes were tested for their electrocatalytic activities. CNT-based sensors generally have higher sensitivities, lower limits of detection, and faster electron transfer kinetics than traditional carbon electrodes. Many variables were tested and then optimized to create a CNT-based sensor. This study highlights different biomolecules and compares electrode design techniques for selective analyte detection. Carbon nanotubes possess similar dimensions to many biological molecules used within biosensors. MWCNTs can be oxidized to form surface carboxyl groups which can then be modified to allow covalent linking to enzymes or others. The design of biofuel cells involves the application of enzymes or microorganisms as catalyst for the targeted oxidation and reduction of specific fuel and oxidizer substrates at both electrodes to generate an electrical power output. The emergence of biofuel cells is driven by the need for clean methods of producing electricity from renewable fuel sources, and the ever-increasing depletion of fossil fuels. Dye molecules for sensor devices exhibits interesting enhancement in the electrocatalytic activity towards the oxidation or reduction of several biochemical and inorganic compounds. Dye for the functionalization of CNTs or Graphene leads to the construction of efficient electrochemical sensors. The above mentioned functional materials/ligands are both electrochemically active and photoactive. So, by using these dye molecules/polymers functionalized CNTs can enhance electrocatalysis and photoelectrocatalysis of various analyte reactions. This photoelectrocatalysis studies could be very helpful for developing new type of biosensors.
Walker, Andrew. "Relating the structure of insect silk proteins to function." Phd thesis, 2013. http://hdl.handle.net/1885/140997.
Full text