Relevant bibliographies by topics / Biomaterials Fabrication

Academic literature on the topic 'Biomaterials Fabrication'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Biomaterials Fabrication"

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Bettinger, Christopher J. "Synthesis and microfabrication of biomaterials for soft-tissue engineering." Pure and Applied Chemistry 81, no. 12 (October 31, 2009): 2183–201. http://dx.doi.org/10.1351/pac-con-09-07-10.

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Biomaterials synthesis and scaffold fabrication will play an increasingly important role in the design of systems for regenerative medicine and tissue engineering. These rapidly growing fields are converging as scaffold design must begin to incorporate multidisciplinary aspects in order to effectively organize cell-seeded constructs into functional tissue. This review article examines the use of synthetic biomaterials and fabrication strategies across length scales with the ultimate goal of guiding cell function and directing tissue formation. This discussion is parsed into three subsections: (1) biomaterials synthesis, including elastomers and gels; (2) synthetic micro- and nanostructures for engineering the cell–biomaterial interface; and (3) complex biomaterials systems design for controlling aspects of the cellular microenvironment.
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Shick, Tang Mei, Aini Zuhra Abdul Kadir, Nor Hasrul Akhmal Ngadiman, and Azanizawati Ma’aram. "A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering." Journal of Bioactive and Compatible Polymers 34, no. 6 (September 25, 2019): 415–35. http://dx.doi.org/10.1177/0883911519877426.

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The current developments in three-dimensional printing also referred as “additive manufacturing” have transformed the scenarios for modern manufacturing and engineering design processes which show greatest advantages for the fabrication of complex structures such as scaffold for tissue engineering. This review aims to introduce additive manufacturing techniques in tissue engineering, types of biomaterials used in scaffold fabrication, as well as in vitro and in vivo evaluations. Biomaterials and fabrication methods could critically affect the outcomes of scaffold mechanical properties, design architectures, and cell proliferations. In addition, an ideal scaffold aids the efficiency of cell proliferation and allows the movements of cell nutrient inside the human body with their specific material properties. This article provides comprehensive review that covers broad range of all the biomaterial types using various additive manufacturing technologies. The data were extracted from 2008 to 2018 mostly from Google Scholar, ScienceDirect, and Scopus using keywords such as “Additive Manufacturing,” “3D Printing,” “Tissue Engineering,” “Biomaterial” and “Scaffold.” A 10 years research in this area was found to be mostly focused toward obtaining an ideal scaffold by investigating the fabrication strategies, biomaterials compatibility, scaffold design effectiveness through computer-aided design modeling, and optimum printing machine parameters identification. As a conclusion, this ideal scaffold fabrication can be obtained with the combination of different materials that could enhance the material properties which performed well in optimum additive manufacturing condition. Yet, there are still many challenges from the printing methods, bioprinting and cell culturing that needs to be discovered and investigated in the future.
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Chow, Lesley W., and Jacob F. Fischer. "Creating biomaterials with spatially organized functionality." Experimental Biology and Medicine 241, no. 10 (May 2016): 1025–32. http://dx.doi.org/10.1177/1535370216648023.

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Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue’s biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biomaterial to recapitulate native tissue organization and function.
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Kuo, Shyh Ming, Shwu Jen Chang, Chun-Hsu Yao, and Ioannis Manousakas. "A PERSPECTIVE VIEW ON THE PREPARATION OF MICRO- AND NANOPARTICULATES OF BIOMATERIALS FROM ELECTROSTATIC AND ULTRASONIC METHODS." Biomedical Engineering: Applications, Basis and Communications 21, no. 05 (October 2009): 343–53. http://dx.doi.org/10.4015/s101623720900143x.

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Developments on tissue engineering, especially on tissue regeneration and drug delivery, demand also developments on biomaterials. Research on the preparation methods of biomaterials has exhibited remarkable advances in the recent years. Natural biomaterials, such as chitosan and collagen, or synthetic materials like poly(lactic acid) can be shaped in various forms. The parameters involved in the fabrication processes provide methodologies for control of the materials' properties, such as morphology, biodegradability, mechanical strength, and adhesion. As new applications develop for these materials, the preparation methods have to be optimized to achieve the desired material properties. These properties mostly not only mimic the conditions in the human body, but also may divert the microenvironment of cells in the diseased area in order to promote faster or guided healing and tissue regeneration. This review pays attention on some of the fabrication methods for biomaterial particulates of sizes in the micro- and nanoscale. The views expressed here focus on the many years of experience of the authors with electrostatic and ultrasonic fabrication methods. These methods are still under development and up to now can produce particulates of various sizes down to the nanometer scale with narrow size distributions. Such biomaterials that have extraordinary properties may provide ways for the development of remarkable biomedical applications.
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Abdullah, Turdimuhammad, Esra Su, and Adnan Memić. "Designing Silk-Based Cryogels for Biomedical Applications." Biomimetics 8, no. 1 (December 22, 2022): 5. http://dx.doi.org/10.3390/biomimetics8010005.

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There is a need to develop the next generation of medical products that require biomaterials with improved properties. The versatility of various gels has pushed them to the forefront of biomaterials research. Cryogels, a type of gel scaffold made by controlled crosslinking under subzero or freezing temperatures, have great potential to address many current challenges. Unlike their hydrogel counterparts, which are also able to hold large amounts of biologically relevant fluids such as water, cryogels are often characterized by highly dense and crosslinked polymer walls, macroporous structures, and often improved properties. Recently, one biomaterial that has garnered a lot of interest for cryogel fabrication is silk and its derivatives. In this review, we provide a brief overview of silk-based biomaterials and how cryogelation can be used for novel scaffold design. We discuss how various parameters and fabrication strategies can be used to tune the properties of silk-based biomaterials. Finally, we discuss specific biomedical applications of silk-based biomaterials. Ultimately, we aim to demonstrate how the latest advances in silk-based cryogel scaffolds can be used to address challenges in numerous bioengineering disciplines.
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Zhang, Bin, Rodica Cristescu, Douglas B. Chrisey, and Roger J. Narayan. "Solvent-based Extrusion 3D Printing for the Fabrication of Tissue Engineering Scaffolds." International Journal of Bioprinting 6, no. 1 (January 17, 2020): 19. http://dx.doi.org/10.18063/ijb.v6i1.211.

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Three-dimensional (3D) printing has been emerging as a new technology for scaffold fabrication to overcome the problems associated with the undesirable microstructure associated with the use of traditional methods. Solvent-based extrusion (SBE) 3D printing is a popular 3D printing method, which enables incorporation of cells during the scaffold printing process. The scaffold can be customized by optimizing the scaffold structure, biomaterial, and cells to mimic the properties of natural tissue. However, several technical challenges prevent SBE 3D printing from translation to clinical use, such as the properties of current biomaterials, the difficulties associated with simultaneous control of multiple biomaterials and cells, and the scaffold-to-scaffold variability of current 3D printed scaffolds. In this review paper, a summary of SBE 3D printing for tissue engineering (TE) is provided. The influences of parameters such as ink biomaterials, ink rheological behavior, cross-linking mechanisms, and printing parameters on scaffold fabrication are considered. The printed scaffold structure, mechanical properties, degradation, and biocompatibility of the scaffolds are summarized. It is believed that a better understanding of the scaffold fabrication process and assessment methods can improve the functionality of SBE-manufactured 3D printed scaffolds.
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Park, In Woo, Kyung Won Kim, Yunhwa Hong, Hyun Ji Yoon, Yonghun Lee, Dham Gwak, and Kwang Heo. "Recent Developments and Prospects of M13- Bacteriophage Based Piezoelectric Energy Harvesting Devices." Nanomaterials 10, no. 1 (January 2, 2020): 93. http://dx.doi.org/10.3390/nano10010093.

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Recently, biocompatible energy harvesting devices have received a great deal of attention for biomedical applications. Among various biomaterials, viruses are expected to be very promising biomaterials for the fabrication of functional devices due to their unique characteristics. While other natural biomaterials have limitations in mass-production, low piezoelectric properties, and surface modification, M13 bacteriophages (phages), which is one type of virus, are likely to overcome these issues with their mass-amplification, self-assembled structure, and genetic modification. Based on these advantages, many researchers have started to develop virus-based energy harvesting devices exhibiting superior properties to previous biomaterial-based devices. To enhance the power of these devices, researchers have tried to modify the surface properties of M13 phages, form biomimetic hierarchical structures, control the dipole alignments, and more. These methods for fabricating virus-based energy harvesting devices can form a powerful strategy to develop high-performance biocompatible energy devices for a wide range of practical applications in the future. In this review, we discuss all these issues in detail.
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Przekora, Agata. "Current Trends in Fabrication of Biomaterials for Bone and Cartilage Regeneration: Materials Modifications and Biophysical Stimulations." International Journal of Molecular Sciences 20, no. 2 (January 20, 2019): 435. http://dx.doi.org/10.3390/ijms20020435.

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The aim of engineering of biomaterials is to fabricate implantable biocompatible scaffold that would accelerate regeneration of the tissue and ideally protect the wound against biodevice-related infections, which may cause prolonged inflammation and biomaterial failure. To obtain antimicrobial and highly biocompatible scaffolds promoting cell adhesion and growth, materials scientists are still searching for novel modifications of biomaterials. This review presents current trends in the field of engineering of biomaterials concerning application of various modifications and biophysical stimulation of scaffolds to obtain implants allowing for fast regeneration process of bone and cartilage as well as providing long-lasting antimicrobial protection at the site of injury. The article describes metal ion and plasma modifications of biomaterials as well as post-surgery external stimulations of implants with ultrasound and magnetic field, providing accelerated regeneration process. Finally, the review summarizes recent findings concerning the use of piezoelectric biomaterials in regenerative medicine.
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Vesvoranan, Oraya, Amritha Anup, and Katherine R. Hixon. "Current Concepts and Methods in Tissue Interface Scaffold Fabrication." Biomimetics 7, no. 4 (October 4, 2022): 151. http://dx.doi.org/10.3390/biomimetics7040151.

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Damage caused by disease or trauma often leads to multi-tissue damage which is both painful and expensive for the patient. Despite the common occurrence of such injuries, reconstruction can be incredibly challenging and often may focus on a single tissue, which has been damaged to a greater extent, rather than the environment as a whole. Tissue engineering offers an approach to encourage repair, replacement, and regeneration using scaffolds, biomaterials and bioactive factors. However, there are many advantages to creating a combined scaffold fabrication method approach that incorporates the treatment and regeneration of multiple tissue types simultaneously. This review provides a guide to combining multiple tissue-engineered scaffold fabrication methods to span several tissue types concurrently. Briefly, a background in the healing and composition of typical tissues targeted in scaffold fabrication is provided. Then, common tissue-engineered scaffold fabrication methods are highlighted, specifically focusing on porosity, mechanical integrity, and practicality for clinical application. Finally, an overview of commonly used scaffold biomaterials and additives is provided, and current research in combining multiple scaffold fabrication techniques is discussed. Overall, this review will serve to bridge the critical gap in knowledge pertaining to combining different fabrication methods for tissue regeneration without disrupting structural integrity and biomaterial properties.
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Chen, Chang Jun, and Min Zhang. "Fabrication Methods of Porous Tantalum Metal Implants for Use as Biomaterials." Advanced Materials Research 476-478 (February 2012): 2063–66. http://dx.doi.org/10.4028/www.scientific.net/amr.476-478.2063.

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Porous tantalum; biomaterials; bone ingrowth; laser cladding; Abstract. Porous tantalum, a new low modulus metal with a characteristic appearance similar to cancellous/trabecular bone, is currently available for use in several orthopedic applications (hip and knee arthroplasty, spine surgery, and bone graft substitute). The open-cell structure of repeating dodecahedrons is produced via carbon vapor deposition/infiltration of commercially pure tantalum onto a vitreous carbon scaffolding. This transition metal maintains several interesting biomaterial properties, including: a high volumetric porosity (70-80%), low modulus of elasticity (3MPa), and high frictional characteristics. Tantalum has excellent biocompatibility and is safe to use in vivo as evidenced by its historical and current use in pacemaker electrodes, cranioplasty plates and as radiopaque markers. The bioactivity and biocompatibility of porous tantalum stems from its ability to form a self-passivating surface oxide layer. This surface layer leads to the formation of a bone-like apatite coating in vivo and affords excellent bone and fibrous in-growth properties allowing for rapid and substantial bone and soft tissue attachment. Tantalum-chondrocyte composites have yielded successful early results in vitro and may afford an option for joint resurfacing in the future. The development of porous tantalum is in its early stages of evolution and the following represents a review of its biomaterial properties and fabrication methods for applications as implant biomaterials.
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Dissertations / Theses on the topic "Biomaterials Fabrication"

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Dougherty, Shelley A. "Template-assisted fabrication of nano-biomaterials." Digital WPI, 2009. https://digitalcommons.wpi.edu/etd-dissertations/351.

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"“One-dimensional” nanostructures like nanotubes and nanorods hold great potential for a wide variety of applications. In particular, one-dimensional nanostructures may be able to provide many significant advantages over traditional spherical particles for drug delivery applications. Recent studies have shown that long, filamentous particles circulate longer within the body than spherical particles, giving them more time to reach the target area and deliver their payload more efficiently. In addition, studies investigating the diffusion of drugs through nanochannels have shown that the drug diffusion profiles can be controlled by varying the nanochannel diameter when the drug diameter and nanochannel diameter are close in size. The combination of increased circulation time and controllable drug release profiles give onedimensional nanostructure great potential for future drug release applications. To fully realize this potential, a simple, low cost, and versatile fabrication method for one-dimensional nanostructures needs to be developed and exploited. The objective of this work is to demonstrate the versatility of template-assisted nanofabrication methods by fabricating a variety of unique protein and polymer one-dimensional nanostructures. This demonstration includes the adaptation of two different template-assisted methods, namely layer-by-layer assembly and template wetting, to fabricate glucose oxidase nanocapsules with both ends sealed, segmented polystyrene and poly(methyl methacrylate) nanorods, and poly(L-lactide)-poly(methyl methacrylate) core-shell nanowires with adjustable shell layer thicknesses. The unique nanostructure morphologies that were achieved using our novel fabrication methods will open the arena for future research focused on process control and optimization for specific applications."
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Huadmai, Jerawala. "A novel processing route for the fabrication of porous magnesium biomaterials." Thesis, University of Canterbury. Engineering, 2005. http://hdl.handle.net/10092/6460.

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Metallic biomaterials continue to play an essential role to assist with the repair or replacement of natural bone that has become diseased or damaged. Metals have high mechanical strength making them better suited to load-bearing applications than polymeric and ceramic biomaterials [1]. At present, stainless steel, Co-Cr alloys and Ti alloys are three main metallic biomaterials used as bone prosthesis [2, 3]. Although these metals are, in monolithic form, biocompatible, fine debris particles and/or ions released over the lifetime of the implantation, coming into contact with the surrounding tissue appear to be not biocompatible. The abnormally high levels of metal ions and/or particles are believed to be associated with carcinogenic, toxic, inflammatory and allergic reactions eventually leading to the prosthesis aseptic loosening [4-10]. High mechanical stiffness of the three metals is also believed to associate with bone resorption – a situation where bone around the implant becomes thinner or more porous. The high stiffness metal, once implanted, changes the distribution of applied load in the adjacent bone [11, 12]. Recently, there have been interests in using magnesium and its alloy as a metallic biomaterial. Magnesium is a bioresorbable metal with an ability to enhance bone healing process [13, 14]. It also has lower stiffness making it more resemble to that of natural bone in terms of mechanical properties. This work presented in this thesis involves an investigation a manufacturing route that is feasible and viable for producing Mg foam for tissue engineering and bone implant applications. The microstructure and mechanical properties of Mg foam is studied and tested then compared with natural human bone.
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Mayor, Elizabeth Laura. "Fabrication and Characterization of Electrospun Poly-Caprolactone-Gelatin Composite Cuffs for Tissue Engineered Blood Vessels." Digital WPI, 2015. https://digitalcommons.wpi.edu/etd-theses/512.

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Strong, durable terminal regions that can be easily handled by researchers and surgeons are a key factor in the successful fabrication of tissue engineered blood vessels (TEBV). The goal of this study was to fabricate and characterize electrospun cuffs made of poly-caprolactone (PCL) combined with gelatin that reinforce and strengthen each end of cell-derived vascular tissue tubes. PCL is ideal for vascular tissue engineering applications due to its mechanical properties; however, PCL alone does not support cell attachment. Therefore, we introduced gelatin, a natural matrix-derived protein, into the electrospun material to promote cell adhesion. This work compared the effects of two different methods for introducing gelatin into the PCL materials: gelatin coating and gelatin co-electrospinning. Porosity, pore size, fiber diameter, and mechanical properties of the electrospun materials were measured in order to compare the features of gelatin PCL composites that have the greatest impact on cellular infiltration. Porosity was quantified by liquid intrusion, fiber diameter and pore size were measured using scanning electron microscopy, and tensile mechanical testing was used to evaluate strength, elastic modulus, and extensibility. Attachment and outgrowth of smooth muscle cells onto cuff materials was measured to evaluate differences in cellular interactions between materials by using a metabolic attachment assay and a cellular outgrowth assay. Finally, cuffs were fused with totally cell-derived TEBV and the integration of cuffs with tissue was evaluated by longitudinal pull to failure testing and histological analysis. Overall, these cuffs were shown to be able to add length and increase strength to the ends of TEBV for tube cannulation and manipulation during in vitro culture. In particular, PCL:gelatin cospun cuffs were shown to improve cellular attachment and cuff fusion compared to pure PCL cuffs, while still increasing the strength of the TEBV terminal ends.
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Grey, Casey. "Tissue Engineering Scaffold Fabrication and Processing Techniques to Improve Cellular Infiltration." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3652.

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Electrospinning is a technique used to generate scaffolds composed of nano- to micron-sized fibers for use in tissue engineering. This technology possesses several key weaknesses that prevent it from adoption into the clinical treatment regime. One major weakness is the lack of porosity exhibited in most electrospun scaffolds, preventing cellular infiltration and thus hosts tissue integration. Another weakness seen in the field is the inability to physically cut electrospun scaffolds in the frontal plane for subsequent microscopic analysis (current electrospun scaffold analysis is limited to sectioning in the cross-sectional plane). Given this it becomes extremely difficult to associate spatial scaffold dynamics with a specific cellular response. In an effort to address these issues the research presented here will discuss modifications to electrospinning technology, cryosectioning technology, and our understanding of cellular infiltration mechanisms into electrospun scaffolds. Of note, the hypothesis of a potentially significant passive phase of cellular infiltration will be discussed as well as modifications to cell culture protocols aimed at establishing multiple passive infiltration phases during prolonged culture to encourage deep cellular infiltration.
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Coffigniez, Marion. "Additive manufacturing of 3D architectured metallic biomaterials by robocasting." Thesis, Lyon, 2021. http://www.theses.fr/2021LYSEI007.

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Au-delà de l'aspect de personnalisation qu'elle peut apporter au domaine médical, la fabrication additive donne aussi accès à l'élaboration de structures cellulaires. Ces structures, de porosité maîtrisée, permettent à la fois de moduler les propriétés mécaniques de l'objet, mais aussi de favoriser l'invasion cellulaire nécessaire en ingénierie tissulaire. Parmi les métaux communément utilisés en chirurgie orthopédique, les alliages de titane sont ceux présentant la rigidité la moins éloignée de celle de l'os. Cette étude porte donc sur l'élaboration de structures en Ti6-Al-4V, mais aussi en magnésium puisqu’il présente l'avantage d'être résorbable dans l'organisme. Les scaffolds sont obtenus par robocasting, procédé consistant à extruder, couche par couche une encre pâteuse constituée de poudre et de liant. Les structures sont ensuite déliantées et frittées à haute température pour atteindre leurs propriétés finales. Concernant les structures en Ti-6Al-4V, une étude paramétrique est effectuée pour évaluer les possibilités et les limites du procédé en termes de structures (et microstructures), de compositions chimiques et de propriétés mécaniques obtenues.Après optimisation, il est possible d'obtenir des pièces présentant deux niveaux de porosités interconnectées (microporosité intra-filament (interconnectée), bénéfique pour l'accroche cellulaire d'après la littérature, et macropores dessinées), gardant une limite d'élasticité spécifique supérieure à celle de l'os (105 MPa.cm³/g) et un module d'Young proche de celui de l'os (28-30 GPa). Un gradient de la porosité intra-filamentaire peut également être obtenu en faisant varier la taille de poudre au sein d’une seule et même pièce. Concernant le magnésium, un liant compatible avec la réactivité de la poudre (base éthanol) a pu être identifié et les premières étapes du procédé (impression, déliantage) sont donc tout à fait réalisables pour ce matériau. Toutefois, le frittage conventionnel du magnésium (pur) s'avère compliqué du fait de sa réactivité. Des alternatives de frittage sont donc étudiées (frittage en phase liquide, SPS)
Beyond the personalisation aspect that it can bring to the medical field, additive manufacturing also gives access to the elaboration of cellular structures. These structures, with controlled porosity, make it possible both to modulate the mechanical properties of the object and to promote the cellular invasion necessary in tissue engineering. Among the metals commonly used in orthopaedic surgery, titanium alloys are those with the rigidity least distant from that of bone. This study therefore focuses on the development of structures made of Ti6-Al-4V, but also of magnesium since it has the advantage of being resorbable in the body. The scaffolds are obtained by robocasting, a process consisting of extruding, layer by layer, a pasty ink made up of powder and binder. The structures have then to be debinded and sintered at high temperature to achieve their final properties. For Ti-6Al-4V structures, a parametric study is carried out to evaluate the possibilities and limits of the process in terms of structures (and microstructures), chemical compositions and mechanical properties obtained. After optimisation, it is possible to obtain parts with two levels of interconnected porosities (intra-filament (interconnected) microporosity, beneficial for cell adhesion according to the literature, and drawn macropores), keeping a specific yield strength higher than that of bone (105 MPa.cm³/g) and a Young's modulus close to that of bone (28-30 GPa). An intra-filament porosity gradient can also be obtained by varying the powder size within a single part. Concerning magnesium, a binder compatible with the reactivity of the powder (ethanol base) has been identified and the first steps of the process (printing, debinding) are therefore quite feasible for this material. However, conventional sintering of (pure) magnesium is complicated by its reactivity. Alternative sintering methods are therefore being investigated (liquid phase sintering, Spark Plasma Sintering)
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Janakiraman, Vijayakumar. "DESIGN, FABRICATION AND CHARACTERIZATION OF BIFURCATING MICROFLUIDIC NETWORKS FOR TISSUE-ENGINEERED PRODUCTS WITH BUILT-IN MICROVASCULATURE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1196457966.

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Tu, Xiaolong. "Fabrication et étude de scaffolds multidimensionnels pour l'ingénierie cellulaire et tissulaire." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEE045/document.

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L'objectif de ce travail est de développer une méthode d'ingénierie de scaffolds multidimensionnels pour la culture cellulaire et l’ingénierie tissulaire. Nous avons d'abord appliqué une technique d'impression 3D pour produire un scaffold en PEGDA et ensuite rempli l'espace libre du scaffold avec du gel de gélatine. Après la congélation et le séchage, un scaffold hybride en PEGDA avec des structures fine de gélatine a été obtenu, qui a été ensuite valisé par la culture et la différenciation des cellules progénitrices neuronales. Pour intégrer plus facilement dans un dispositif microfluidique, nous avons également conçu un scaffold 2D sous forme d’une couche mince de nid d'abeilles de PEGDA rempli des structures poreuses auto-assemblée de PCL. Ce scaffold 2D a été utilisé pour la culture cellulaire et la transfection des gènes, montrant des avantages par rapport aux méthodes classiques en termes d'absorption des nutriments et des facteurs solubles. Enfin, nous avons fabriqué un scaffold mous constitué d’une couche mince de nid d'abeilles en élastomère de PDMS et d’une monocouche de nanofibres de gélatine pour faciliter la différenciation cardiaque à partir des cellules souches pluripotentes humaine. Comme prévu, nous avons réalisé une génération cardiaque avec une contraction plus forte et une homogénéité de battement plus élevée par rapport aux approches classiques. Tous ensemble, nous avons démontré l'utilité des scaffolds hybrides pour l'ingénierie micro-tissulaire qui pourraient avoir un impact sur les études futures dans les domaines de l'ingénierie tissulaire, du criblage des médicaments et de la médecine régénératrice
The objective of this work is to develop a method of engineering multi-dimensional scaffolds for cell culture and tissue formation. We firstly applied a 3D printing technique to produce the designed frame in PEGDA and then filled the free-space of the frame with a gelatin gel. After freezing and drying, a hybrid 3D scaffold made of gelatin porous structures and PEDGA backbone was obtained, which supported culture and differentiation of neural progenitor cells. To more easily integrate into a microfluidic device, we also designed a 2D scaffold in form of a thin layer of honeycomb frame of PEGDA and self-assembled porous structure of PCL. Such a patch form scaffold could be used for cell culture and gene transfection, showing advantages over the conventional methods in terms of nutrients and soluble factors uptake. Finally, we fabricated a soft patch made of an elastic frame in PDMS and a monolayer of gelatin nanofibers to facilitate cardiac differentiation from human induced pluripotent stem cells. As expected, we achieved a cardiac generation with higher contraction strength and a higher beating homogeneity comparing to the conventional approaches. All together, we demonstrated the utility of hybrid scaffolds for micro-tissue engineering which could impact the future studies in the fields of tissue engineering, drug screening and regenerative medicine
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Petet, Thomas J. Jr. "Characterization of Poly(dimethylsiloxane) Blends and Fabrication of Soft Micropillar Arrays for Force Detection." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4649.

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Diseases involving fibrosis cause tens of thousands of deaths per year in the US alone. These diseases are characterized by a large amount of extracellular matrix, causing stiff abnormal tissues that may not function correctly. To take steps towards curing these diseases, a fundamental understanding of how cells interact with their substrate and how mechanical forces alter signaling pathways is vital. Studying the mechanobiology of cells and the interaction between a cell and its extracellular matrix can help explain the mechanisms behind stem cell differentiation, cell migration, and metastasis. Due to the correlation between force, extracellular matrix assembly, and substrate stiffness, it is vital to make in vitro models that more accurately simulate biological stiffness as well as measure the amount of force and extracellular matrix assembly. To accomplish this, blends of two types of poly(dimethylsiloxane) (PDMS) were made and the material properties of these polymer blends were characterized. A field of 5µm or 7µm microscopic pillars (referred to as posts) with a diameter of 2.2µm were fabricated from these blends. Each combination of PDMS blend and post height were calibrated and the stiffness was recorded. Additionally, polymer attachment experiments were run to ensure cells survived and had a normal phenotype on the different blends of PDMS when compared to pure PDMS. Finally, cells were placed onto a field of posts and their forces were calculated using the new stiffness found for each blend of post. Varying the PDMS material stiffness using blends allow posts to be much more physiologically relevant and help to create more accurate in vitro models while still allowing easy and accurate force measurement. More biologically relevant in vitro models can help us acquire more accurate results when testing new drugs or examining new signaling pathways.
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James, Colby M. "Assessment of electrospinning as an in-house fabrication technique for blood vessel mimic cellular scaffolding." DigitalCommons@CalPoly, 2009. https://digitalcommons.calpoly.edu/theses/185.

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Intravascular devices, such as stents, must be rigorously tested before they can be approved by the FDA. This includes bench top in vitro testing to determine biocompatibility, and animal model testing to ensure safety and efficacy. As an intermediate step, a blood vessel mimic (BVM) testing method has been developed that mimics the three dimensional structure of blood vessels using a perfusion bioreactor system, human derived endothelial cells, and a biocompatible polymer scaffold used to support growth of the blood vessel cells. The focus of this thesis was to find an in-house fabrication method capable of making cellular scaffolding for use in the BVM. Research was conducted based on three aims. The first aim was to survey possible fabrication methods to choose a technique most appropriate for producing BVM scaffolding. The second aim was to set up the selected fabrication method (electrospinning) in-house at Cal Poly and gain understanding of the process. The third aim was to evaluate consistency of the technique. The work described in this thesis determined that electrospinning is a viable fabrication technique for producing scaffolding for BVM use. Electrospun scaffolding is highly tailorable, and a structure that mimics the natural organization of nano sized collagen fibers is especially desirable when culturing endothelial cells. An electrospinning apparatus was constructed in house and a series of trial experiments was conducted to better understand the electrospinning process. A consistency study evaluated scaffold reproducibility between different spins and within individual spins while setting a baseline that can be used for comparison in future work aimed at electrospinning.
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Pal, Ramendra K. "Fabrication of flexible, biofunctional architectures from silk proteins." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4995.

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Advances in the biomedical field require functional materials and processes that can lead to devices that are biocompatible, and biodegradable while maintaining high performance and mechanical conformability. In this context, a current shift in focus is towards natural polymers as not only the structural but also functional components of such devices. This poses material-specific functionalization and fabrication related questions in the design and fabrication of such systems. Silk protein biopolymers from the silkworm show tremendous promise in this regard due to intrinsic properties: mechanical performance, optical transparency, biocompatibility, biodegradability, processability, and the ability to entrap and stabilize biomolecules. The unique ensemble of properties indicates opportunities to employ this material into numerous biomedical applications. However, specific processing, functionalization, and fabrication techniques are required to make a successful transition from the silk cocoon to silk-based devices. This research is focused on these challenges to form silk-based functional material and devices for application in areas of therapeutics, bio-optics, and bioelectronics. To make silk proteins mechanically conformable to biological tissues, the first exploration is directed towards the realization of precisely micro-patterned silk proteins in flexible formats. The optical properties of silk proteins are investigated by showing the angle-dependent iridescent behavior of micropatterned proteins, and developing soft micro-optical devices for light concentration and focusing. The optical characteristics and fabrication process reported in the work can lead to the future application of silk proteins in flexible optics and electronics. The microfabrication process of silk proteins is further extended to form shape-defined silk protein microparticles. Here, the specificity of shape and the ability to form monodisperse shapes can be used as shape encoded efficient cargo and contrast agents. Also, these particles can efficiently entrap and stabilize biomolecules for drug delivery and bioimaging applications. Next, a smart confluence of silk sericin and a synthetic functional polymer PEDOT:PSS is shown. The composite materials obtained have synergistic effects from both polymers. Silk proteins impart biodegradability and patternability, while the intrinsically conductive PEDOT:PSS imparts electrical conductivity and electrochemical activity. Conductive micro architectures on rigid as well as flexible formats are shown via a green, water-based fabrication process. The applications of the composite are successfully demonstrated by realizing biosensing and energy storage devices on rigid or flexible forms. The versatility of the approach will lead to the development of a variety of applications such as in bio-optics, bioelectronics, and in the fundamental study of cellular bio electrogenic environments. Finally, to expand the applicability of reported functional polymers and composites beyond the microscale, a method for silk nano-patterning via electron beam lithography is explored. The technique enables one-step fabrication of user defined structures at the submicron and nano-scales. By virtue of acrylate chemistry, a very low energetic beam and dosage are required to form silk nano-architectures. Also, the process can form both positive and negative features depending on the dosage. The fabrication platform can also form nano scale patterns of the conductive composite. The conductive measurements confirm the formation of conductive nanowires and the ability of silk sericin to entrap PEDOT:PSS particles in nanoscale features.
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Books on the topic "Biomaterials Fabrication"

1

M, Chakravartula Ayyana, ed. Mechanics of biomaterials: Fundamental principles for implant design. Cambridge: Cambridge University Press, 2011.

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Chu, Paul K., and Xuanyong Liu. Biomaterials Fabrication and Processing Handbook. Taylor & Francis Group, 2008.

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Chu, Paul K., and Xuanyong Liu. Biomaterials Fabrication and Processing Handbook. Taylor & Francis Group, 2008.

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(Editor), Paul K. Chu, and Xuanyong Liu (Editor), eds. Biomaterials Fabrication and Processing Handbook. CRC, 2008.

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Chu, Paul K., and Xuanyong Liu, eds. Biomaterials Fabrication and Processing Handbook. CRC Press, 2008. http://dx.doi.org/10.1201/9780849379741.

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Chu, Paul K., and Xuanyong Liu. Biomaterials Fabrication and Processing Handbook. Taylor & Francis Group, 2008.

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Kuanr, Bijoy Kumar, Pooja Agarwal, Anjali Gupta, and Divya Bajpai Tripathy. Polymeric Biomaterials: Fabrication, Properties and Applications. Taylor & Francis Group, 2023.

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Kuanr, Bijoy Kumar, Pooja Agarwal, Anjali Gupta, and Divya Bajpai Tripathy. Polymeric Biomaterials: Fabrication, Properties and Applications. Taylor & Francis Group, 2023.

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Kuanr, Bijoy Kumar, Pooja Agarwal, Anjali Gupta, and Divya Bajpai Tripathy. Polymeric Biomaterials: Fabrication, Properties and Applications. Taylor & Francis Group, 2023.

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Gilson, Khang, Kim Moon Suk, and Lee Hai Bang, eds. A manual for biomaterials: Scaffold fabrication technology. Singapore: World Scientific, 2007.

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Book chapters on the topic "Biomaterials Fabrication"

1

Seidi, Azadeh, and Murugan Ramalingam. "Protocols for Biomaterial Scaffold Fabrication." In Integrated Biomaterials in Tissue Engineering, 1–23. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118371183.ch1.

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Ishikawa, Kunio, Shigeki Matsuya, Yumiko Suzuki, Koh-ichi Udoh, Masaharu Nakagawa, and Kiyoshi Koyano. "Fabrication of Apatite Monolith from Calcium Sulphate." In Advanced Biomaterials VI, 533–36. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.533.

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Li, Hu, Hong Song Fan, and Xing Dong Zhang. "Fabrication of Porous Titanium with Biomechanical Compatibility." In Advanced Biomaterials VI, 611–14. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.611.

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Lu, Xia, Li Ang Xing, Pei Zhi Wang, and Jun Fu. "Fabrication and Bioactivity of Porous Titanium Implant." In Advanced Biomaterials VII, 613–16. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.613.

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Hiraoka, Yosuke, Ueda Hiroki, Yu Kimura, and Yasuhiko Tabata. "Fabrication and Characterization of Mechanically Reinforced Collagen Sponge." In Advanced Biomaterials VI, 385–88. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.385.

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Scott, Taylor E., and Scott A. Guelcher. "Chapter 9. Advanced Scaffold Fabrication using Additive Manufacturing." In Biomaterials Science Series, 226–51. Cambridge: Royal Society of Chemistry, 2022. http://dx.doi.org/10.1039/9781839166013-00226.

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Amirthalingam, Sivashanmugam, and Jayakumar Rangasamy. "Chitosan-Based Biosensor Fabrication and Biosensing Applications." In Chitosan for Biomaterials III, 233–55. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/12_2021_85.

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Starly, Binil. "Computer-Aided Process Planning for the Layered Fabrication of Porous Scaffold Matrices." In Printed Biomaterials, 39–55. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1395-1_3.

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Wang, Xin Long, Z. Wang, Hong Song Fan, Yu Mei Xiao, and Xing Dong Zhang. "Fabrication of Porous Hydroxyapatite Ceramics by Microwave Sintering Method." In Advanced Biomaterials VI, 529–32. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.529.

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Lee, Jin Woo, Byung Kim, Geun Bae Lim, and Dong Woo Cho. "Scaffold Fabrication with Biodegradable Poly(propylene fumarate) Using Microstereolithography." In Advanced Biomaterials VII, 141–44. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.141.

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Conference papers on the topic "Biomaterials Fabrication"

1

Huang, N., P. Yang, R. Guenzel, P. K. Chu, and T. F. Xi. "SURFACE MODIFICATION OF BLOOD CONTACTING BIOMATERIALS." In Processing and Fabrication of Advanced Materials VIII. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812811431_0025.

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Mahmoud, Rahmatul, Quang Nguyen, Gordon Christopher, and Paul F. Egan. "3D Printed Food Design and Fabrication Approach for Manufacturability, Rheology, and Nutrition Trade-Offs." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-70663.

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Abstract 3D printing enables the production of personalized designs that are desirable in the medical industry for applications including orthopedics, tissue engineering, and personalized nutrition. Currently, the design process relies on trial-and-error approaches, especially for biomaterial development, and there is a need for methodologies to streamline the design process to facilitate automation. Here, we investigate a design methodology for printing foods by mixing novel biomaterial combinations informed by rheological measurements that indicate printability. The process consists of first printing basic designs with chocolate, marzipan, and potato biomaterials known to print consistently. Rheological measurements are collected for these materials and compared to a novel pumpkin biomaterial. The pumpkin had a higher complex modulus and lower mechanical loss tangent than all other biomaterials, therefore motivating the addition of rheological agents to reach more favorable properties. Varied concentrations of corn starch and guar gum were added to the pumpkin to improve printability while altering the nutrient distribution. A 4% inclusion of guar gum provided the most consistent pumpkin prints. A complex 3D object was fabricated with the 4% guar gum pumpkin material, therefore demonstrating the merits in using rheological properties to inform printability for use in design automation routines. The design approach enabled comparisons of relative nutrition and printability trade-offs to demonstrate a proof-of-concept user interface for design automation to facilitate customized food production. Further research to develop a complete design methodology for linking rheological properties to printability would promote consistent prediction of print quality for novel formulations to support design automation, with potential generalizability for diverse biomaterials.
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Honarmandi, Peyman. "Fabrication of Single-Crystal Nanospherical Hydroxyapatite Powder for Biomedical Applications." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13326.

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The competence and compatibility of biomaterials is always challenging and demanding in biotech industries. Hydroxyapatite (HAp) is a useful biomaterial for biological applications due to its especial properties. In this paper, a dry mechanochemical process is introduced to produce hydroxyapatite nanoparticles. Structural and morphological properties of HAp powder are studied by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The results show that the single-crystal HAp nanospherical particles are successfully produced during milling process. Two different metallic and polymeric vials are applied and the results are compared for both vials. The results verify that the HAp nanoparticles are single crystal and their sizes are in the ranges of 12–24 nm.
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Sanders, Joan E., Sam T. Bishop, Charlotte E. Stiles, and Philipp K. Schuessler. "Fibroin and Polymer-Based Fibroporous Biomaterials: Candidate Materials for Biomechanical Implants?" In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0919.

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Abstract A technique from the paper manufacturing industry was used to manufacture fibroporous meshes for potential biomaterial implant applications. Meshes were made from small diameter (10 μm) bombyx mori cocoon silk (fibroin). Meshes with a range of fiber lengths were created, though at long fiber lengths flocculation (clumping of fibers) tended to occur. Load-deformation curves were nonlinear with lower slopes at high loads than at low loads, contrary to natural soft-tissue biomaterials. Single fiber in vivo studies to evaluate tissue response sensitivity to biomaterial architectural features demonstrated reduced fibrous encapsulation for smaller diameter fibers (2.6 μm) than larger ones (10 μm). Thus the use of small diameter fibers in biomaterial fibrous implants is a viable concept, and it should be pursued. However, alternative methods to the paper manufacturing process will need to be used for mesh fabrication.
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Boland, Thomas, Xiaofeng Cui, Aditya Chaubey, Timothy C. Burg, Richard E. Groff, and Karen J. L. Burg. "Precision Printing of Cells and Biomaterials Onto 3D Matrices." In ASME 2007 International Manufacturing Science and Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/msec2007-31023.

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The long term goal of our work is to develop a fabrication technique that allows precision placement of cells inside biomaterial constructs. Such spatial and temporal control of the chemistry and pattern geometry can provide new insights into fundamental aspects of cell-surface interactions. For example, cellular development can be dramatically effected by constraining cells to spread over a specific cell-surface contact area. The cell and biomaterial printing techniques developed here may prove particularly useful for exploring the interactions of anchorage-dependent cells with their environment in vitro. Our recent studies addressed the simultaneous printing of endothelial cells and biomaterials. The studies further demonstrated that cells can be printed onto polymer scaffolds or fibers without significant loss of cell activity. A combination of these methods may result in the construction of vascularized tissue with mechanical properties approaching those of native tissue.
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Weigel-Jech, M., F. Niewiera, and S. Fatikow. "Towards automated handling of biomaterials for nano-biosensor fabrication." In 2010 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM). IEEE, 2010. http://dx.doi.org/10.1109/aim.2010.5695848.

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Qiu, Weiguo, Joseph Cappello, and Xiaoyi Wu. "Fabrication of Genetically Engineered Silk-Elastin-Like Protein Polymer Fibers." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-190980.

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Micro- and submicro-diameter protein fibers are fundamental building blocks of extra- and intra-cellular matrices, providing structural support, stability and protection to cells, tissues and organism [1]. Fabricating performance fibers of both naturally derived and genetically engineered proteins has been extensively pursued for a variety of biomedical applications, including tissue engineering and drug delivery [2]. Silk-elastin-like proteins (SELPs), consisting of tandemly repeated polypeptide sequences derived from silk and elastin, have been biosynthesized using recombinant DNA technique [3]. Their potential as a biomaterials in the form of hydrogels continues to be explored [4, 5]. This study will focus on the fabrication of robust, micro-diameter SELP fibers as biomaterials for tissue engineering applications.
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Nakayama, Atsushi, Yasuaki Kumamoto, Atsushi Taguchi, and Katsumasa Fujita. "Photoinitiator-free micro/nano fabrication of biomaterials with nonlinear deep UV excitation." In Advanced Fabrication Technologies for Micro/Nano Optics and Photonics XV, edited by Georg von Freymann, Eva Blasco, and Debashis Chanda. SPIE, 2022. http://dx.doi.org/10.1117/12.2608630.

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9

Jung, W., B. Paulson, K. Choi, J. Y. Son, T. Nazari, S. H. Park, J. H. Kim, and K. Oh. "Fabrication and characteristics of thin-film waveguides based on DNA biomaterials." In SPIE Organic Photonics + Electronics, edited by Manfred Eich, Jean-Michel Nunzi, and Rachel Jakubiak. SPIE, 2013. http://dx.doi.org/10.1117/12.2024713.

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Lu, Lin, Robert S. Dembzynski, Mark J. Mondrinos, David Wootton, Peter I. Lelkes, and Jack Zhou. "Manufacturing System Development for Fabrication of Bone Scaffold." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80937.

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Musculoskeletal conditions are a major health concern in United States because of a large aging population and increased occurrence of sport-related injuries. The need for bone substitutes is especially important. Traditional treatments of bone-defect have many of limitations. Bone tissue engineering may offer a less painful alternative to traditional bone grafts with lower risk of infection. This research integrates biomimetic modeling, solid freeform fabrication (SFF), systems and control, and tissue engineering in one intelligent system for structured, highly porous biomaterials, which will be applied to bone scaffolds. Currently a new SFF-based fabrication system has been developed, which uses a pressurized extrusion to print highly biocompatible and water soluble sucrose bone scaffold porogens. To date, this system can build simple bone structures. In parallel we are utilizing a commercial rapid prototyping (RP) machine to fabricate thermoplastic porogens of various designs to determine the feasibility of injecting a highly viscous scaffold material into porogens. Materials which have been successfully used to make scaffolds by injection include calcium phosphate cement (CPC), molten poly-caprolactone (PCL), 90/10 and 80/20 (v/v %) composite of PCL and calcium phosphate (CaPO4,). Results presented for the injection method include characterization of attainable feature resolution of the RP machine, as well as preliminary cell-biomaterial interaction data demonstrating biocompatibility of CPC scaffolds. The preliminary results using a commercial rapid prototyping machine have demonstrated that the indirect porogen technique can improve 2–4 folds the resolution of SFF system in fabricating bone scaffolds. The resultant scaffolds demonstrate that the defined porous structures will be suitable for tissue engineering applications.
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