Relevant bibliographies by topics / Biomanufacturing applications

Academic literature on the topic 'Biomanufacturing applications'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Biomanufacturing applications"

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Mann, Madison M., Toriana N. Vigil, Samantha M. Felton, William E. Fahy, Mason A. Kinkeade, Victoria K. Kartseva, Mary-Jean C. Rowson, Abigail J. Frost, and Bryan W. Berger. "Proteins in Synthetic Biology with Agricultural and Environmental Applications." SynBio 1, no. 1 (November 21, 2022): 77–88. http://dx.doi.org/10.3390/synbio1010006.

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Synthetic biology tools have become increasingly prevalent as we look to nature for biological approaches to complex problems. With an ever-growing global population, issues of food safety and security, as well as addressing pollution and striving for sustainability are of the utmost importance. In this review, we first highlight synthetic biology techniques such as directed evolution as a toolset for protein engineering and show direct applications for food safety and security. Moreover, we offer an introduction to creative approaches for biosensor design and development and spotlight a few innovative examples. Finally, we address biomanufacturing with direct applications, as well as biomanufacturing to improve natural processes.
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Sugita, Naohiko, and Mamoru Mitsuishi. "Special Issue on Biomanufacturing." International Journal of Automation Technology 8, no. 1 (January 5, 2014): 73. http://dx.doi.org/10.20965/ijat.2014.p0073.

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The development of medical devices and systems is essential for improving quality of life and reducing global healthcare costs. Machine tools are increasingly used in the medical, automotive, airplane, and electronics fields thanks to advances in manufacturing technology. The processing of artificial implants and biomaterials, for example, and parts of medical devices such as endoscopes are manufactured with multiaxis machine tools. This demand is expected to increase as society ages. Equipment used in diagnostics and surgery has also developed rapidly. Despite the use of advanced diagnostics such as computed tomography (CT) and magnetic resonance imaging (MRI), however, surgery still largely depends on the skill and sense of the surgeon. Advanced manufacturing technologies are thus needed to achieve these desired attributes. Biomanufacturing requires expertise in basic manufacturing processes such as cutting, electrophysical and chemical processes, forming, and abrasive processes. These, in turn, must be integrated into machine design, surface modification, precision engineering, and metrology within the overarching frameworks of design, life cycle engineering and assembly, production systems, and organization. Biomanufacturing is thus defined as the application of design and manufacturing technologies for reducing cost while advancing safety, quality, efficiency and speed in healthcare services and biomedical sciences. Biomanufacturing provides an excellent platform for converging innovations in precision engineering, nanotechnology, biotechnology, information technology, and cognitive sciences. This special issue presents the latest in research advances, practical and theoretical applications, and case studies on biomanufacturing. The papers featured in this issue provide aid in the development of next-generation manufacturing technologies. We thank the authors for their invaluable contributions and the reviewers for their ever- useful advice. We know you will find this special issue both fascinating and worthwhile.
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Yuan, Jianhua, Jianglin Cao, Fei Yu, Jie Ma, Dong Zhang, Yijing Tang, and Jie Zheng. "Microbial biomanufacture of metal/metallic nanomaterials and metabolic engineering: design strategies, fundamental mechanisms, and future opportunities." Journal of Materials Chemistry B 9, no. 33 (2021): 6491–506. http://dx.doi.org/10.1039/d1tb01000j.

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Biomanufacturing metal/metallic nanomaterials with ordered micro/nanostructures, controllable functions, and promising properties is of great importance in both fundamental studies and practical applications.
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Vilkhovoy, Michael, Abhinav Adhikari, Sandra Vadhin, and Jeffrey D. Varner. "The Evolution of Cell Free Biomanufacturing." Processes 8, no. 6 (June 8, 2020): 675. http://dx.doi.org/10.3390/pr8060675.

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Cell-free systems are a widely used research tool in systems and synthetic biology and a promising platform for manufacturing of proteins and chemicals. In the past, cell-free biology was primarily used to better understand fundamental biochemical processes. Notably, E. coli cell-free extracts were used in the 1960s to decipher the sequencing of the genetic code. Since then, the transcription and translation capabilities of cell-free systems have been repeatedly optimized to improve energy efficiency and product yield. Today, cell-free systems, in combination with the rise of synthetic biology, have taken on a new role as a promising technology for just-in-time manufacturing of therapeutically important biologics and high-value small molecules. They have also been implemented at an industrial scale for the production of antibodies and cytokines. In this review, we discuss the evolution of cell-free technologies, in particular advancements in extract preparation, cell-free protein synthesis, and cell-free metabolic engineering applications. We then conclude with a discussion of the mathematical modeling of cell-free systems. Mathematical modeling of cell-free processes could be critical to addressing performance bottlenecks and estimating the costs of cell-free manufactured products.
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Afghah, Ferdows, Caner Dikyol, Mine Altunbek, and Bahattin Koc. "Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing." Applied Sciences 9, no. 17 (August 28, 2019): 3540. http://dx.doi.org/10.3390/app9173540.

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Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.
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Chan, Weng Wan, Fang Yu, Quang Bach Le, Sixun Chen, Marcus Yee, and Deepak Choudhury. "Towards Biomanufacturing of Cell-Derived Matrices." International Journal of Molecular Sciences 22, no. 21 (November 3, 2021): 11929. http://dx.doi.org/10.3390/ijms222111929.

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Cell-derived matrices (CDM) are the decellularised extracellular matrices (ECM) of tissues obtained by the laboratory culture process. CDM is developed to mimic, to a certain extent, the properties of the needed natural tissue and thus to obviate the use of animals. The composition of CDM can be tailored for intended applications by carefully optimising the cell sources, culturing conditions and decellularising methods. This unique advantage has inspired the increasing use of CDM for biomedical research, ranging from stem cell niches to disease modelling and regenerative medicine. However, while much effort is spent on extracting different types of CDM and exploring their utilisation, little is spent on the scale-up aspect of CDM production. The ability to scale up CDM production is essential, as the materials are due for clinical trials and regulatory approval, and in fact, this ability to scale up should be an important factor from the early stages. In this review, we first introduce the current CDM production and characterisation methods. We then describe the existing scale-up technologies for cell culture and highlight the key considerations in scaling-up CDM manufacturing. Finally, we discuss the considerations and challenges faced while converting a laboratory protocol into a full industrial process. Scaling-up CDM manufacturing is a challenging task since it may be hindered by technologies that are not yet available. The early identification of these gaps will not only quicken CDM based product development but also help drive the advancement in scale-up cell culture and ECM extraction.
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Neville, Jonathan J., Joe Orlando, Kimberly Mann, Bethany McCloskey, and Michael N. Antoniou. "Ubiquitous Chromatin-opening Elements (UCOEs): Applications in biomanufacturing and gene therapy." Biotechnology Advances 35, no. 5 (September 2017): 557–64. http://dx.doi.org/10.1016/j.biotechadv.2017.05.004.

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Kis, Zoltán, Hugo Sant'Ana Pereira, Takayuki Homma, Ryan M. Pedrigi, and Rob Krams. "Mammalian synthetic biology: emerging medical applications." Journal of The Royal Society Interface 12, no. 106 (May 2015): 20141000. http://dx.doi.org/10.1098/rsif.2014.1000.

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In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON–OFF switches, categorized into transcriptional, post-transcriptional, translational and post-translational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks to drug discovery, drug delivery, receptor-activating gene circuits and mammalian biomanufacturing processes.
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Papathanasiou, Maria M., Baris Burnak, Justin Katz, Nilay Shah, and Efstratios N. Pistikopoulos. "Assisting continuous biomanufacturing through advanced control in downstream purification." Computers & Chemical Engineering 125 (June 2019): 232–48. http://dx.doi.org/10.1016/j.compchemeng.2019.03.013.

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Skylar-Scott, Mark A., Sebastien G. M. Uzel, Lucy L. Nam, John H. Ahrens, Ryan L. Truby, Sarita Damaraju, and Jennifer A. Lewis. "Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels." Science Advances 5, no. 9 (September 2019): eaaw2459. http://dx.doi.org/10.1126/sciadv.aaw2459.

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Engineering organ-specific tissues for therapeutic applications is a grand challenge, requiring the fabrication and maintenance of densely cellular constructs composed of ~108 cells/ml. Organ building blocks (OBBs) composed of patient-specific–induced pluripotent stem cell–derived organoids offer a pathway to achieving tissues with the requisite cellular density, microarchitecture, and function. However, to date, scant attention has been devoted to their assembly into 3D tissue constructs. Here, we report a biomanufacturing method for assembling hundreds of thousands of these OBBs into living matrices with high cellular density into which perfusable vascular channels are introduced via embedded three-dimensional bioprinting. The OBB matrices exhibit the desired self-healing, viscoplastic behavior required for sacrificial writing into functional tissue (SWIFT). As an exemplar, we created a perfusable cardiac tissue that fuses and beats synchronously over a 7-day period. Our SWIFT biomanufacturing method enables the rapid assembly of perfusable patient- and organ-specific tissues at therapeutic scales.
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Dissertations / Theses on the topic "Biomanufacturing applications"

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Padmaperuma, Gloria. "Microalgal co-cultures for biomanufacturing applications." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/20714/.

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High demands in consumer goods and pressures from governments to meet environmental regulations have pushed industries to find innovative, carbon-neutral solutions. Sustainable methods in biotechnology are sought to increase productivity whilst keeping at bay one of the major problems in monoculture production routes: contamination. The use of engineered consortia is seen as a viable option. In nature, microorganisms exist as part of complicated networks known as consortia. Within the consortia, each member plays a role in facilitating communication, tasks distribution, nutrients acquisition and protection. This emerging field uses the conundrums that govern natural microbial assemblages to create artificial co-culture within the laboratory. Purpose fit, co-cultures have been created, to enhance productivity yields of desired products, for bioremediation and to circumvent contamination. The use of microalgae in co-cultures is the focus of this study. Microalgae have application in many fields and are ideal candidates for bioproduction and carbon sequestration. The results of two different systems are presented, which aim to increase the productivity of microalgae biomass and of β-carotene or lipids. The natural consortium of Dunaliella salina, Halomonas and Halobacterium salinarum showed both an increase in microalgae cell concentration by 79% and higher β-carotene productivity compared to the monoculture. This association also showed that Halomonas is able to aid D. salina when subjected to abiotic stress. The artificial co-culture of Scenedesmus obliquus and Rhodosporidium toruloides showed an increase in microalgae biomass by 20%; however, the FAME levels of 26% dw were not a significant increase, compared to monocultures. Both systems demonstrated that if one member of the assemblage is in dire stress, this stress will translate to the entire community. Characterisation of exopolymeric substances and metabolites provided a fuller picture on how these microorganisms co-exist. Additionally, a novel method, duo-plates, was developed and successfully tested to trap metabolites within co-cultures.
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Bas, Onur. "Deterministic design & additive biomanufacturing of biomimetic soft network composites for tissue engineering applications." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/116584/10/Onur_Bas_Thesis.pdf.

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Design strategies inspired by nature open up new avenues in materials design and facilitate the development of innovative materials outperforming their conventionally engineered counterparts. In this thesis, bioinspired design principles based on the physicochemical and morphological properties of soft biological materials were used to develop functional soft network composites (SNCs) intended for soft tissue engineering applications. These SNCs consist of a network of 3D printed microfibres and a hydrogel matrix mimicking the collagens and proteoglycans present in native extracellular matrices, respectively. Our results suggest that this new class of composites are suitable for tissue engineering a broad range of soft tissues including cartilage, skin, ligament, tendon, muscle and heart valve.
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Book chapters on the topic "Biomanufacturing applications"

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Singh, Sunpreet, Chander Prakash, Manjeet Singh, Guravtar Singh Mann, Munish Kumar Gupta, Rupinder Singh, and Seeram Ramakrishna. "Poly-lactic-Acid: Potential Material for Bio-printing Applications." In Biomanufacturing, 69–87. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13951-3_3.

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Bhushan, Jagat, and Vishakha Grover. "Additive Manufacturing: Current Concepts, Methods, and Applications in Oral Health Care." In Biomanufacturing, 103–22. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13951-3_5.

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Zia, Abdul Wasy. "Effective Heat Treatment for Improvement in Diamond-like Carbon Coatings for Biomedical Applications." In Biomanufacturing, 205–24. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13951-3_10.

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Ranjan, Nishant, Rupinder Singh, and IPS Ahuja. "Material Processing of PLA-HAp-CS-Based Thermoplastic Composite Through Fused Deposition Modeling for Biomedical Applications." In Biomanufacturing, 123–36. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-13951-3_6.

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Szyszka, Taylor N., Lachlan S. R. Adamson, and Yu Heng Lau. "Encapsulin Nanocompartments for Biomanufacturing Applications." In Microbial Production of High-Value Products, 309–33. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-06600-9_12.

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Lian, Xiaojun, and Sean P. Palecek. "Biomanufacturing Human Pluripotent Stem Cells for Therapeutic Applications." In Advances in Stem Cell Research, 29–48. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-940-2_3.

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Marklein, Ross A., Morgan Mantay, Cheryl Gomillion, and James N. Warnock. "Biomanufacturing of Mesenchymal Stromal Cells for Therapeutic Applications." In Cell Engineering, 267–306. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79871-0_9.

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Huang, Boyang, Henrique Almeida, Bopaya Bidanda, and Paulo Jorge Bártolo. "Additive Biomanufacturing Processes to Fabricate Scaffolds for Tissue Engineering." In Virtual Prototyping & Bio Manufacturing in Medical Applications, 95–124. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-35880-8_5.

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Liu, Fengyuan, Cian Vyas, Jiong Yang, Gokhan Ates, and Paulo Jorge Bártolo. "A Review of Hybrid Biomanufacturing Systems Applied in Tissue Regeneration." In Virtual Prototyping & Bio Manufacturing in Medical Applications, 187–213. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-35880-8_8.

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Bakeev, Katherine A., and Jose C. Menezes. "Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing." In Process Analytical Technology, 521–43. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470689592.ch16.

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Conference papers on the topic "Biomanufacturing applications"

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Zhou, Yi Yu. "The impact of the “vaccine fraud incident” on the biomanufacturing industry - Based on the domino effect." In 2019 5TH INTERNATIONAL CONFERENCE ON GREEN POWER, MATERIALS AND MANUFACTURING TECHNOLOGY AND APPLICATIONS (GPMMTA 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5137865.

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Almeida, Henrique A., and Paulo J. Ba´rtolo. "The Use of Schwartz Geometries for Scaffold Design in Tissue Engineering Applications." In ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2010. http://dx.doi.org/10.1115/esda2010-25385.

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Additive biomanufacturing processes are increasingly recognised as ideal techniques to produce scaffolds for tissue engineering applications. Scaffolds provide a temporary mechanical and vascular support for tissue regeneration while shaping the in-growth tissues. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and pore distribution and optimal vascularisation, with both surface and structural compatibility. Surface compatibility means a chemical, biological and physical suitability to the host tissue. Structural compatibility corresponds to an optimal adaptation to the mechanical behaviour of the host tissue. Recent advances in the tissue engineering field are increasingly relying on modelling and simulation. The design of optimised scaffolds based on the fundamental knowledge of its microstructure is a relevant topic of research. This paper proposes the use of novel geometric structures based on the Triple Periodic Minimal Surfaces formulation, namely the Schwartz primitives, one of the a sub-classes of Triple Periodic Minimal Surfaces. Schwartz primitives enables the design of vary high surface-to-volume ratio structures with high porosity and mechanical/vascular properties. With the use of a computational tool combining structural, computational fluid dynamics and topological optimisation schemes, it is possible to predict and optimise both mechanical and vascular behaviour of scaffolds for soft and hard tissue applications, with different topological architectures and levels of porosity. This tool is particularly important to quantify the structural heterogeneity and scaffold mechanical properties with a designed microstructure subjected to either a single or a multiple load distribution. This computational tool enables the simulation of biological flows in vascular passages of scaffolds. The blood flow considered in this study is a complex fluid comprising a suspension of red blood cells, white blood cells and platelets within a newtonian plasma.
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Almeida, Henrique A., and Paulo J. Ba´rtolo. "Computer Simulation and Optimisation of Tissue Engineering Scaffolds: Mechanical and Vascular Behaviour." In ASME 2008 9th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2008. http://dx.doi.org/10.1115/esda2008-59460.

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Additive biomanufacturing processes are increasingly recognised as ideal techniques to produce scaffolds for tissue engineering applications. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and pore distribution and optimal vascularisation, with both surface and structural compatibility. Surface compatibility means a chemical, biological and physical suitability to the host tissue. Structural compatibility corresponds to an optimal adaptation to the mechanical behaviour of the host tissue. Recent advances in tissue engineering field are increasingly relying on modelling and simulation. This paper proposes a novel computational tool combining structural, computational fluid dynamics and topological optimisation schemes, to predict and optimise both mechanical and vascular behaviour of scaffolds for soft and hard tissue applications, with different topological architectures and levels of porosity. This tool is particularly important to quantify the structural heterogeneity and scaffold mechanical properties with a designed microstructure subjected to either a single or a multiple load distribution. This computational tool enables the simulation of biological flows in vascular passages of scaffolds. The blood flow considered in this study is a complex fluid comprising a suspension of red blood cells, white blood cells and platelets within a newtonian plasma. A topological optimisation scheme is being developed to obtain the ideal scaffold topological architectures.
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