Journal articles: 'Biologically important compounds'

1

Hart, John P., and Malcolm R. Smyth. "Electroanalysis of biologically important compounds." Analytica Chimica Acta 244 (1991): 295–96. http://dx.doi.org/10.1016/s0003-2670(00)82517-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Covington, A. K. "Electroanalysis of biologically important compounds." Electrochimica Acta 36, no. 14 (January 1991): 2196. http://dx.doi.org/10.1016/0013-4686(91)85234-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Bartlett, P. N. "Electroanalysis of biologically important compounds." Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 310, no. 1-2 (July 1991): 454. http://dx.doi.org/10.1016/0022-0728(91)85283-u.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Perrett, D. "Electroanalysis of biologically important compounds." Chromatographia 38, no. 11-12 (June 1994): 792. http://dx.doi.org/10.1007/bf02269638.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Kissinger, P. T. "Electroanalysis of biologically important compounds." Journal of Chromatography B: Biomedical Sciences and Applications 568, no. 1 (July 1991): 270. http://dx.doi.org/10.1016/0378-4347(91)80364-i.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Mugesh, Govindasamy, Wolf-Walther du Mont, and Helmut Sies. "Chemistry of Biologically Important Synthetic Organoselenium Compounds." Chemical Reviews 101, no. 7 (July 2001): 2125–80. http://dx.doi.org/10.1021/cr000426w.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Deshmukh, A. R., B. Bhawal, D. Krishnaswamy, Vidyesh Govande, Bidhan Shinkre, and A. Jayanthi. "Azetidin-2-ones, Synthon for Biologically Important Compounds †." Current Medicinal Chemistry 11, no. 14 (July 1, 2004): 1889–920. http://dx.doi.org/10.2174/0929867043364874.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Moriarty, Robert M., Yi-Yin Ku, and Udai S. Gill. "Novel cyclopentadienyl ruthenium(II) complexes of biologically important compounds." Journal of the Chemical Society, Chemical Communications, no. 24 (1987): 1837. http://dx.doi.org/10.1039/c39870001837.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Honda, Y., R. Navarro-Gonzalez, and C. Ponnamperuma. "Chemical yields of biologically important compounds from electric discharges." International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 33, no. 3 (January 1989): 287. http://dx.doi.org/10.1016/1359-0197(89)90202-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Mugesh, Govindasamy, Wolf-Walther du Mont, and Helmut Sies. "ChemInform Abstract: Chemistry of Biologically Important Synthetic Organoselenium Compounds." ChemInform 32, no. 39 (May 24, 2010): no. http://dx.doi.org/10.1002/chin.200139275.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Karaaslan, Cigdem, and Sibel Suzen. "Electrochemical Behavior of Biologically Important Indole Derivatives." International Journal of Electrochemistry 2011 (2011): 1–10. http://dx.doi.org/10.4061/2011/154804.

Full text

Abstract:

Voltammetric techniques are most suitable to investigate the redox properties of a new drug. Use of electrochemistry is an important approach in drug discovery and research as well as quality control, drug stability, and determination of physiological activity. The indole nucleus is an essential element of a number of natural and synthetic products with significant biological activity. Indole derivatives are the well-known electroactive compounds that are readily oxidized at carbon-based electrodes, and thus analytical procedures, such as electrochemical detection and voltammetry, have been developed for the determination of biologically important indoles. This paper explains some of the relevant and recent achievements in the electrochemistry processes and parameters mainly related to biologically important indole derivatives in view of drug discovery and analysis.

APA, Harvard, Vancouver, ISO, and other styles

12

Berger, Rainer. "The Synthesis of Biologically Important Organic Compounds from Abiologic Systems." Bulletin des Sociétés Chimiques Belges 72, no. 3-4 (September 2, 2010): 255–63. http://dx.doi.org/10.1002/bscb.19630720309.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Gupta, Khushbu, and Tejpal Singh Chundawat. "Role of Enzymes in Synthesis of Biologically Important Organic Scaffolds." Asian Journal of Chemistry 31, no. 12 (November 16, 2019): 2698–706. http://dx.doi.org/10.14233/ajchem.2019.22205.

Full text

Abstract:

Green route of biogenic synthesis of heterocyclic compounds via microbes (bacteria, fungi, virus, yeast, algae, etc.) has the potential to deliver clean manufacturing technology. The application of biocatalysts for the synthesis of novel compounds has attracted increasing attention over the past few years and consequently, high demands have been placed on the identification of new biocatalysts for organic synthesis. Enzymes play an increasingly important role as biocatalysts in the synthesis of key intermediates for the pharmaceutical and chemical industry, and new enzymatic technologies. The characteristics of biocatalyst can be tailored with protein engineering and metabolic engineering methods to meet the desired process conditions. This review discusses the synthetic application of all the six classes of enzymes which are oxidoreductase, transferase, hydrolase, lyase, isomerase and ligase. Enzymes are highly selective catalysts and their contribution to regio-, chemo- and stereoselectivity of compounds were also discussed.

APA, Harvard, Vancouver, ISO, and other styles

14

Yu, Bin, Hui Xing, De-Quan Yu, and Hong-Min Liu. "Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update." Beilstein Journal of Organic Chemistry 12 (May 18, 2016): 1000–1039. http://dx.doi.org/10.3762/bjoc.12.98.

Full text

Abstract:

Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these compounds, enantioenriched 3-hydroxyoxindole scaffolds also exist in natural products and have proven to possess promising biological activities. A large number of catalytic asymmetric strategies toward the construction of 3-hydroxyoxindoles based on transition metal catalysis and organocatalysis have been reported in the last decades. Additionally, 3-hydroxyoxindoles as versatile precursors have also been used in the total synthesis of natural products and for constructing structurally novel scaffolds. In this review, we aim to provide an overview about the catalytic asymmetric synthesis of biologically important 3-substituted 3-hydroxyoxindoles and 3-hydroxyoxindole-based further transformations.

APA, Harvard, Vancouver, ISO, and other styles

15

Škvareninová, Katarína, Štefan Baláž, Ernest Šturdík, Miroslav Veverka, Jana Adamcová, and Jana Olexová. "Biologically Important Physicochemical Properties of Some Cephalosporins." Collection of Czechoslovak Chemical Communications 57, no. 8 (1992): 1739–46. http://dx.doi.org/10.1135/cccc19921739.

Full text

Abstract:

In the series of cephalosporin derivatives, consisting of eight 7-(R1-CH2-CO-NH)cephalosporanic acids and of seven analogical compounds with 3-acetoxymethyl replaced by 3-CH3, physicochemical properties, which are expected to play a role in their antibacterial effects (the transport rate parameters and partition coefficients in the systems 1-octanol-water and 1-octanol-buffer, dissociation constants of the 4-carboxyl group, reactivity towards L-glutathione imitating the nucleophilic groups of the cell components and hydrolysis rate parameters), were determined. Linear dependences were observed between the partition coefficients and the π-constants of the varying substituents as well as between reactivity towards SH-groups of L-glutathione and OH-groups. The relationship between the transport rate parameters and partition coefficients, both measured in buffered as well as non-buffered system, was described by a common non-linear equation.

APA, Harvard, Vancouver, ISO, and other styles

16

Sinko, J., J. Rajchard, Z. Balounova, and L. Fikotova. " Biologically active substances from water invertebrates: a review." Veterinární Medicína 57, No. 4 (May 18, 2012): 177–84. http://dx.doi.org/10.17221/5914-vetmed.

Full text

Abstract:

Some species of invertebrates especially bryozoans (Bryozoa syn. Ectoprocta) and marine sponges (Porifera) are very important sources of pharmacologically exploitable compounds. These substances are probably produced to protect themselves from fish predators and may be an advantage in competition. The real sources of compounds with these antipredatory effects are probably not marine invertebrates themselves, but microscopic symbionts or food which they feed on. Bryostatins from bryozoan species Bugula neritina are produced by a bacterial symbiont called Candidatus Endobugula sertula. They have significant anti-cancer effects, but also other therapeutic benefits. Compounds with the structure of bryostatins were also discovered in some other invertebrates. Sponges are a source of many compounds, e.g., ara-A (vidarabine), manzamine, lasonolides, spongistatins, peloruside and others with antimicrobial, anti-cancer, immunosuppressive and similar activities. Other important sources of compounds with medical effects are tunicates (Tunicata syn. Urochordata) and some snails (Mollusca). One drug was developed from tunicates – Yondelis against refractory soft-tissue sarcomas. Certain other drugs originate from snails: e.g., prialt, which acts against chronic pain in spinal cord injury.  

APA, Harvard, Vancouver, ISO, and other styles

17

Thakur, Abhinay, Rohit Sharma, Vivek Sheel Jaswal, Eugenie Nepovimova, Ashun Chaudhary, and Kamil Kuca. "Psoralen: A Biologically Important Coumarin with Emerging Applications." Mini-Reviews in Medicinal Chemistry 20, no. 18 (December 7, 2020): 1838–45. http://dx.doi.org/10.2174/1389557520666200429101053.

Full text

Abstract:

Coumarin belongs to a class of lactones that are fundamentally comprised of a benzene ring fused to an α-pyrone ring; these lactones are known as benzopyrones. Similarly, coumarin has a conjugated electron-rich framework and good charge-transport properties. Plants produce coumarin as a chemical response to protect themselves from predation. Coumarins are used in different products, such as cosmetics, additives, perfumes, aroma enhancers in various tobaccos and some alcoholic drinks, and they play a relevant role in natural products and in organic and medicinal chemistry. In addition, as candidate drugs, many coumarin compounds have strong pharmacological activity, low toxicity, high bioavailability and better curative effects and have been used to treat various types of diseases. Various endeavors were made to create coumarin-based anticoagulant, antimicrobial, antioxidant, anticancer, antidiabetic, antineurodegenerative, analgesic and anti-inflammatory agents. A class of chemical compounds called furocoumarins has phototoxic properties and is naturally synthesized via the fusion of coumarin to a furan ring in different plant species. Psoralens belong to the furocoumarin class and occur naturally in various plants, e.g., lemons, limes, and parsnips. Angelicin is an isomer of psoralens, and most furocoumarins, e.g., xanthotoxin, bergapten, and nodekenetin, are derivatives of psoralens or angelicin. The present work demonstrated that psoralen molecules exhibit anti-tumoral activity against breast cancer and influence different intracellular signals to maintain the high survival of breast cancer cells. Psoralens perform different functions, e.g., antagonize metabolic pathways, protease enzymes, and cell cycle progression and even interfere in the crosslinking between receptors and growth factor mitogenic signaling.

APA, Harvard, Vancouver, ISO, and other styles

18

Baláž, Štefan, Ernest Šturdík, Regina Ujhelyová, Dušan Valigura, Michal Uher, Miroslav Veverka, Václav Konečný, Jana Adamcová, Peter Michalík, and Július Brtko. "Biologically Important Physicochemical Properties of Kojic Acid Derivatives." Collection of Czechoslovak Chemical Communications 58, no. 3 (1993): 693–701. http://dx.doi.org/10.1135/cccc19930693.

Full text

Abstract:

Physicochemical properties (hydrophobicity, acidity, metal complexing ability), which are expected to play a role in biological activity of kojic acid derivatives, were determined for 35 compounds. The structure-property relationship were analysed with the aim to predict the properties of new derivatives and to obtain the data for formulation of quantitative structure-time-activity relationships. Linear correlations were found between hydrophobicity expressed as decadic logarithm of the 1-octanol/buffer partition coefficient and the sum of fragment constants and correlation factors according to Leo and Hansch as well as between acidity and a set of Hammett constants of the varying substituents.

APA, Harvard, Vancouver, ISO, and other styles

19

Roberts, Stanley M., M. Gabriella Santoro, and Eugene S. Sickle. "The emergence of the cyclopentenone prostaglandins as important, biologically active compounds." Journal of the Chemical Society, Perkin Transactions 1, no. 15 (July 9, 2002): 1735–42. http://dx.doi.org/10.1039/b110043m.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Parkash, Ram, Hari Om Gupta, and Jatinder Dutt. "Chronopotentiometric studies of certain biologically important compounds at tubular graphite electrode." Collection of Czechoslovak Chemical Communications 56, no. 9 (1991): 1833–37. http://dx.doi.org/10.1135/cccc19911833.

Full text

Abstract:

The chronopotentiometric studies of certain phenothiazines in hydrodynamic systems at a solution flow-through tubular graphite electrode were carried out in sulfuric acid of different concentrations. A well-defined single wave (involving 2 electrons) in 0.1M H2SO4 and two waves (involving 1 electron each) in 2.0M H2SO4 were observed. Phenothiazines are oxidized trough the formation of a monocation radical by the elimination of one electron from the lone pair of N-atom. The monocation radical is stable in sulfuric acid of a moderate concentration and is unstable in neutral or less acidic solutions. The cation radical undergoes instantaneous hydrolysis yielding sulfoxide, thus presenting an overall two-electron oxidation of the phenothiazine derivatives. The suitability of the chronopotentiometric technique for their determination was established.

APA, Harvard, Vancouver, ISO, and other styles

21

Winterbourn, Christine C., and Diana Metodiewa. "Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide." Free Radical Biology and Medicine 27, no. 3-4 (August 1999): 322–28. http://dx.doi.org/10.1016/s0891-5849(99)00051-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Roberts, Stanley M., M. Gabriella Santoro, and Eugene S. Sickle. "The Emergence of the Cyclopentenone Prostaglandins as Important, Biologically Active Compounds." ChemInform 34, no. 1 (January 7, 2003): no. http://dx.doi.org/10.1002/chin.200301235.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Elkhateeb, Waill A., Dina E. El-Ghwas, and Daba GM. "Mushrooms and Lichens the Factory of Important Secondary Metabolites: Review." Journal of Biomedical Research & Environmental Sciences 4, no. 6 (June 2023): 1072–82. http://dx.doi.org/10.37871/jbres1770.

Full text

Abstract:

Mushrooms and lichens are plentiful source of nutritional and medicinal compounds. However, medicinal uses of the mushrooms and lichens still need to be worked out for their biological activities. Mushrooms and Lichens have reserved their position centuries ago as food and medicine. They are rich in nutrients and in biologically active compounds that belong to different chemical classes. Capabilities of different members of mushrooms and Lichens have encouraged researchers to investigate further applications of these macrofungi and lichens in fields of food and pharmaceutical industries and also other than food and pharmaceutical industries. This review, aims to put together Lentinan, schizophyllan, Betulinans A and B, ganoderic acid, cordycepin and usnic acid under light spot through representing their importance as biological activities exerted by ever one. Further studies and investigations are fortified in order to find more about these interesting natural products.

APA, Harvard, Vancouver, ISO, and other styles

24

Naicker, Tricia. "Special Issue: Advances in the Synthesis of Biologically Important Intermediates/Drugs." Applied Sciences 13, no. 4 (February 13, 2023): 2390. http://dx.doi.org/10.3390/app13042390.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Karan, Ram, Pooja Agarwal, Mukty Sinha, and Neelima Mahato. "Recent Advances on Quinazoline Derivatives: A Potential Bioactive Scaffold in Medicinal Chemistry." ChemEngineering 5, no. 4 (October 26, 2021): 73. http://dx.doi.org/10.3390/chemengineering5040073.

Full text

Abstract:

This paper intended to explore and discover recent therapeutic agents in the area of medicinal chemistry for the treatment of various diseases. Heterocyclic compounds represent an important group of biologically active compounds. In the last few years, heterocyclic compounds having quinazoline moiety have drawn immense attention owing to their significant biological activities. A diverse range of molecules having quinazoline moiety are reported to show a broad range of medicinal activities like antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, antibacterial, antioxidant and other activities. This study accelerates the designing process to generate a greater number of biologically active candidates.

APA, Harvard, Vancouver, ISO, and other styles

26

Siddharth, Saket, and Ravishankar V. Rai. "Actinomycetes as a Paramount Source of Biologically Important Enzyme Inhibitors – “A Boon to Mankind”." Current Bioactive Compounds 15, no. 1 (February 6, 2019): 19–30. http://dx.doi.org/10.2174/1573407213666170116161747.

Full text

Abstract:

Background:Bioactive compounds from microorganisms have been widely studied for several biological, therapeutic and pharmaceutical importances. Bacterial secondary metabolites have proven their worth as a prolific source of antibiotics, antifungal, antiviral, anticholesterol and immunosuppressant. The majority of inhibitors are secondary metabolites of varying chemical moieties produced by microorganisms among which actinomycetes are most important due to their tremendous diversity. Actinomycetes are most economically and commercially important prokaryotes known for their metabolic versatility. They have gained attention due to their ability to produce novel bioactive compounds with many applications. This review provides an overview on well-established actinobacterial bioactive compounds used as enzyme inhibitors for the treatment and management of diseases and their future perspectives.Objective:We focused on actinobacterial bioactive compounds which were reported to possess enzyme inhibition activity. An extensive search on well-acknowledged enzyme inhibitors was done by referring to peer-reviewed research papers. The papers were screened on the basis of the significance of research work done.Results:The research papers referred in this review article suggest the potential of bioactive compounds as therapeutically important enzyme inhibitors. The actinobacterial compounds were found to possess enzyme inhibition potential and could be developed into an antibacterial, antifungal, antimetastatic, antidiabetic and antihypertensive agent. These inhibitors were structurally elucidated and belonged to the class of peptides, proteins and pseudotrisaccharides.Conclusion:The findings of this review paper highlight the enormous potential of actinomycetes and bioactive compounds as enzyme inhibitors of therapeutic and pharmaceutical importance.

APA, Harvard, Vancouver, ISO, and other styles

27

Amadi, Ugochukwu B., Martin O. C. Ogwuegbu, Conrad K. Enenebeaku, and Gerald O. Onyedika. "A Review on Synthesis, Lanthanide Complexes and Biological Activites of Hydrazone Derivatives of Hydrazinecarbothioamides." International Research Journal of Pure and Applied Chemistry 24, no. 5 (September 11, 2023): 54–63. http://dx.doi.org/10.9734/irjpac/2023/v24i5825.

Full text

Abstract:

Hydrazinecarbothioamides are important intermediates with biological activities in organic chemistry synthesis, especially in the synthesis of biologically active heterocyclic scaffolds and compounds. The uniqueness in of synthesis and a wild range of pharmaceutical, medicinal biological potentials and properties, their preferred application as building brick in and the synthesis of heterocyclic and other important organic compounds and nonlinear optical (NLO) materials have made them attractive derivatives of thiosemicarbazides in the recent years. In this review, a detailed account in terms of synthesis and applications of their hydrazone derivatives and their lanthanide complexes are presented .Further, the biological and analytical applications of newly reported ligands and their complexes are reported. The wide investigation of the lanthanide (III) coordination complexes with organic ligands are mainly due to their structures and strong potential biological and pharmacological properties of hydrazones as derivatives of hydrazinecarbothioamides possess sites that play important roles in the formation of heterocyclics and other biologically active scaffolds.

APA, Harvard, Vancouver, ISO, and other styles

28

Kochetkov, Konstantin A., Olga N. Gorunova, and Natalia A. Bystrova. "Biologically Oriented Hybrids of Indole and Hydantoin Derivatives." Molecules 28, no. 2 (January 6, 2023): 602. http://dx.doi.org/10.3390/molecules28020602.

Full text

Abstract:

Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of important hybrid molecules. The series of hybrid compounds containing indoles and imidazolidin-2-one moiety with direct C–C bond were synthesized using an amidoalkylation one-pot reaction. All compounds were investigated as a growth regulator for germination, growth and development of wheat seeds (Triticum aestivum L). Their effect on drought resistance at very low concentrations (4 × 10−5 M) was evaluated. The study highlighted identified the leading compounds, 3a and 3e, with higher growth-regulating activity than the indole-auxin analogues.

APA, Harvard, Vancouver, ISO, and other styles

29

Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, and Divya Rama. "Synthetic applications of biologically important Mannich bases: An updated review." Open Access Research Journal of Biology and Pharmacy 7, no. 2 (March 30, 2023): 001–15. http://dx.doi.org/10.53022/oarjbp.2023.7.2.0015.

Full text

Abstract:

Mannich bases are the beta-amino ketones carrying compounds. Mannich reaction is a nucleophilic addition reaction (nucleophiles such as halogen ions (I-, Br-, Cl- ), the hydroxide ion (OH- ), cyanide ion (CN-), ammonia and water, which involves the condensation of three components, viz., ammonia or a primary amine or a secondary amine or with amides, a non-enolizable aldehyde, usually formaldehyde and a compound containing an active hydrogen atom. These three compounds condense with the concomitant release of the water molecule to produce a new base known as a mannich base, in which the active hydrogen is replaced by an amino methyl group. During the past decades, there has been a great deal of interest in the synthesis of mannich bases. Mannich base can be synthesized by using microwave irradiation, one pot, catalyst-free, retrospective asymmetric synthesis, solvent-free and ultrasonic-assisted synthetic techniques. The literature studies enlighten the fact that mannich bases are a key step in the synthesis of a wide variety of natural products, pharmaceuticals and so forth. Mannich bases play a vital role in the coordination chemistry and the development of metal complexes. Mannich bases have remained an important and popular area of research due to their simple synthesis, adaptability and diverse range of applications. Thus, mannich bases and their derivatives may be further used for enormous biological applications with potent effects.

APA, Harvard, Vancouver, ISO, and other styles

30

Kurbanoglu, Sevinc, Mehmet Altay Unal, and Sibel A. Ozkan. "Recent developments on electrochemical flow injection in pharmaceuticals and biologically important compounds." Electrochimica Acta 287 (October 2018): 135–48. http://dx.doi.org/10.1016/j.electacta.2018.04.217.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Yang, Yu-pei, Nusrat Hussain, Liu Zhang, Yan-zhe Jia, Yu-qing Jian, Bin Li, Muhammad Iqbal Choudhary, Atta-ur Rahman, and Wei Wang. "Kadsura coccinea: A rich source of structurally diverse and biologically important compounds." Chinese Herbal Medicines 12, no. 3 (July 2020): 214–23. http://dx.doi.org/10.1016/j.chmed.2020.03.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Tylko, Grzegorz, Wincenty M. Kilarski, and Marek Mikrut. "Indirect Measurement of Biologically Important Compounds by Means of X-Ray Microanalysis." Microchimica Acta 139, no. 1-4 (May 1, 2002): 189–93. http://dx.doi.org/10.1007/s006040200060.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Honda, Yasuhiro, Rafael Navarro-González, and Cyril Ponnamperuma. "A quantitative assay of biologically important compounds in simulated primitive earth experiments." Advances in Space Research 9, no. 6 (January 1989): 63–66. http://dx.doi.org/10.1016/0273-1177(89)90209-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Karpenko, Yu V., S. M. Kulish, and N. А. Al Halaf. "Biologically oriented synthesis of medicines (BIODS) based on heterylpoxid 2,5-disubstituted 1,3,4-oxadiazoles (Part 2)." Current issues in pharmacy and medicine: science and practice 14, no. 3 (October 25, 2021): 390–98. http://dx.doi.org/10.14739/2409-2932.2021.3.243664.

Full text

Abstract:

Heterocyclic compounds make a very important branch of organic chemistry, and it has always been an interesting area of study in medical chemistry. They are present in a variety of drugs, vitamins and biologically active compounds. Over two decades, 1,3,4-oxadiazoles have been of interest to chemists owing to their diverse therapeutic potential; the studies focus mainly on the principles of combinatorial chemistry with a broad spectrum of biological activity. In the continuation of the review article, the general literature sources that consider chemical heteryl derivatives of 2,5-disubstituted 1,3,4-oxadiazoles as important synthetic substrates and precursors for biologically oriented synthesis, are systematized. Heterocyclic 1,3,4-oxadiazoles and their derivatives are widely used as antibacterial, fungicidal, anti-inflammatory, antidiabetic, anticancer, antitubercular, antioxidant, antimalarial, analgesic, anticonvulsant, antidepressant and anti-HIV drugs. It is important to note that the combination of 1,3,4-oxadiazole nuclei with different heterocyclic moieties in some cases had synergistic effect. The aim of the work is the search for new activities, systematization and generalization of literature sources on methods of biologically oriented drug synthesis (BIODS) based on heteryl derivatives of 2,5-disubstituted 1,3,4-oxadiazoles. Conclusions. The article analyzes, generalizes and systematizes the data obtained from the literature that describes the results of the study of the biological activity of 1,3,4-oxadiazoles, which allowed to confirm their diverse pharmacological and biological potential. It is established that oxadiazoscafold as the main structural component is found in various biologically active compounds which evidences the relevance of its further studies as a perspective structural matrix for construction of drug-like molecules. The analysis of the presented material demonstrates the significance and prospectivity of biologically oriented drugs of this segment of the chemistry of nitrogen-containing heterocycles.

APA, Harvard, Vancouver, ISO, and other styles

35

Yang, Yan-Tao, Jun-Fang Zhu, Guochao Liao, Hai-Jiang Xu, and Bin Yu. "The Development of Biologically Important Spirooxindoles as New Antimicrobial Agents." Current Medicinal Chemistry 25, no. 19 (May 30, 2018): 2233–44. http://dx.doi.org/10.2174/0929867325666171129131311.

Full text

Abstract:

Background: Antibiotic resistance is one of the biggest threats to global health today, leading to higher medical costs and increased mortality. Because of the emergence and rapid spread of new resistance mechanisms globally, a growing number of infections are becoming harder to treat as the antibiotics used to treat them become less effective. Therefore, the development of new effective antimicrobial agents is still urgently needed. In last decades, a large number of structurally novel spirooxindoles have been synthesized mainly based on the ylide intermediates generated in situ and further assessed for their antimicrobial activity against different types of bacteria, leading to the discovery of some potent lead compounds with antimicrobial potentials. Objective: The aim of this review to submarize recent advances on the synthesis, structure- activity relationship studies (SARs) and antimicrobial activity of spirooxindoles. Methods: Peer-reviewed research work on spirooxindoles with antimicrobial activity were downloaded from bibliographic databases and analyzed based on their chemoptypes. Results: 50 papers were retrieved from the literature databases, of which 20 papers described the synthesis and antimicrobial activity of spirooxindoles. Conclusion: This review highlights the importance of spirooxindoles as potential antimicrobial agents. The antimicrobial activity of spirooxindoles against different types of bacteria is less studied, mainly centering on primary antimicrobial assessment, some of these compounds have showed interesting antimicrobial activity. However, the current study is only limited to primary antimicrobial assessment, no detailed modes of action are investigated.

APA, Harvard, Vancouver, ISO, and other styles

36

Salakhutdinov, Nariman F., Konstantin P. Volcho, and Olga I. Yarovaya. "Monoterpenes as a renewable source of biologically active compounds." Pure and Applied Chemistry 89, no. 8 (July 26, 2017): 1105–17. http://dx.doi.org/10.1515/pac-2017-0109.

Full text

Abstract:

AbstractMonoterpenes and their derivatives play an important role in the creation of new biologically active compounds including drugs. The review focuses on the data on various types of biological activity exhibited by monoterpenes and their derivatives, including analgesic, anti-inflammatory, anticonvulsant, antidepressant, anti-Alzheimer, anti-Parkinsonian, antiviral, and antibacterial (anti-tuberculosis) effects. Searching for novel potential drugs among monoterpene derivatives shows great promise for treating various pathologies. Special attention is paid to the effect of absolute configuration of monoterpenes and monoterpenoids on their activity.

APA, Harvard, Vancouver, ISO, and other styles

37

Mithlesh, Pawan K. Pareek, Hemraj Chippa, Ravikant, and Krishan G. Ojha. "Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety." Collection of Czechoslovak Chemical Communications 75, no. 3 (2010): 275–87. http://dx.doi.org/10.1135/cccc2009051.

Full text

Abstract:

2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.

APA, Harvard, Vancouver, ISO, and other styles

38

Hosny, Mona A., Wafaa A. Mokbe, and Emtithal A. El-Sawi. "Synthesis and Evaluation of Important Biologically Active Heterocyclic Compounds: Schiff Bases, Oxadiazole and Pyrazolyl Derivatives." JOURNAL OF ADVANCES IN CHEMISTRY 9, no. 2 (April 7, 2013): 1892–99. http://dx.doi.org/10.24297/jac.v9i2.2341.

Full text

Abstract:

In this work, we prepared an excellent yield of (2-oxo-2H-pyrano[3,2-h] quinolin-4-yl) acetic acid; compound (1) and from the reaction of it with hydrazine hydrate (100%) we obtain 2-(2-oxo-2H-pyrano [3,2-h] quinolin-4-yl) aceto hydrazide (2) which is the starting material for the synthesis of several series of new compounds: such as schiff’s bases (3a-e) and compound (4) in good yields, hydrazide derivatives like compound (5), derivatives of mercapto oxadiazole as compound (6) and derivatives of pyrazolyl as compound (7). All these compounds were found to possess high antimicrobial activity against G+ and G- bacteria and against antifungal as described in scheme (1). Anticancer activity was screened only for compound (1). The IC50 value of it against breast cancer was found = 6.83 µM comparable with that of the drug of doxorubicin which has IC50 = 5.6. As a result these newly compounds from (1) to (7) are considerable as potent compounds for various pharmacological activities.

APA, Harvard, Vancouver, ISO, and other styles

39

Panda, Siva S., Adel S. Girgis, Marian N. Aziz, and Mohamed S. Bekheit. "Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold." Molecules 28, no. 2 (January 7, 2023): 618. http://dx.doi.org/10.3390/molecules28020618.

Full text

Abstract:

Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways. The present article summarizes the recent development of both natural and synthetic spirooxindole-containing compounds prepared from isatin or its derivatives reported in the last five years. The spirooxindoles are categorized based on their mentioned biological properties.

APA, Harvard, Vancouver, ISO, and other styles

40

Rajchard, J. "Sex pheromones in amphibians: a review ." Veterinární Medicína 50, No. 9 (March 28, 2012): 385–89. http://dx.doi.org/10.17221/5637-vetmed.

Full text

Abstract:

Amphibians are interesting animals, very often kept by aquarists and vivarists. Their ability of intraspecific chemical signalization belongs to very interesting biological features. The skin glands of anurans secrete various biologically active compounds. The pheromones are peptides consisting of various numbers of amino acid residues and their synthesis is regulated by hormones (e.g. prolactin and androgens). Similarly, the responsiveness of the vomeronasal epithelium to some of these compounds is enhanced by some hormonal substances (prolactin and oestrogen). Hypophyseal hormones, arginine vasotocin and gonadotropin-releasing hormone are involved in the humoral regulation of pheromone discharge. The storage of some compounds with pheromonal activity in a biologically inactive form was also proved. The pheromones have an important role in sexual relationships. These chemosignals increase female receptivity and are probably involved in the mate choice. The courtship pheromone signals may be conserved across related species. Chemosignals play an important role in female attraction and/or territorial announcement. In addition to sex pheromones, various neuropeptides, antimicrobial and other biologically active peptides were found in skin glands of these amphibians. The infochemical system can be disturbed by a chemical influence in the environment.

APA, Harvard, Vancouver, ISO, and other styles

41

El-Behairy, Mohammed Farrag, Rasha M. Hassan, and Eirik Sundby. "Enantioselective Chromatographic Separation and Lipase Catalyzed Asymmetric Resolution of Biologically Important Chiral Amines." Separations 8, no. 10 (September 30, 2021): 165. http://dx.doi.org/10.3390/separations8100165.

Full text

Abstract:

Cyanoacetamides are vital synthons in synthetic organic chemistry. However, methods to enantiopure cyanoacetamides have not yet been well explored. In this work, the preparation of cyanoacetamide synthons RS-(1a–4a) or methoxyacetamides RS-(1b–4b) in enantiopure/enriched form was investigated. Compounds S-1, S-2, R-1b, R-1a, andR-2b were prepared in enantiopure form (ee > 99%) while compounds S-4, R-2a, and R-4a were achieved in ee 9%, 80%, and 76%, respectively. Many baselines enantioselective HPLC separations of amines 1–4, their cyanoacetamides (1a–4a), and methoxyacetamides (1b–4b) were achieved by utilizing diverse mobile-phase compositions and two cellulose-based CSPs (ODH® and LUX-3® columns). Such enantioselective HPLC separations were used to monitor the lipase-catalyzed kinetic resolution of amines RS-(1–4).

APA, Harvard, Vancouver, ISO, and other styles

42

Ziarani, Ghodsi M., Fatemeh Mohajer, Razieh Moradi, and Parisa Mofatehnia. "The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds." Current Organic Synthesis 16, no. 7 (December 26, 2019): 953–67. http://dx.doi.org/10.2174/1570179416666190925162215.

Full text

Abstract:

Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I and III) and novel microtubule assembly inhibitors. It should be mentioned that spiro-pyrazole also has biological activities like cytotoxic, antimicrobial, anticonvulsant, antifungal, anticancer, anti-inflammatory, and cardiotonic activities. Objective: Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses. This review disclosed the advances in the use of urazole as the starting material in the synthesis of various biologically active molecules from 2006 to 2019. Conclusion: Compounds of urazole (1,2,4-triazolidine-3,5-dione) are the most important molecules which are highly active from the biological perspective in the pharmaceuticals as well as polymers. In summary, many protocols for preparations of the urazole derivatives from various substrates in multi-component reactions have been reported from different aromatic and aliphatic groups which have had carbonyl groups in their structures. It is noted that several catalysts have been synthesized to afford applicable molecules with urazole scaffolds. In some papers, being environmentally friendly, short time reactions and high yields are highlighted in the protocols. There is a room to synthesize new catalysts and perform new reactions by manipulating urazole to produce biologically active compounds, even producing chiral urazole component as many groups of chiral urazole compounds are important from biological perspective.

APA, Harvard, Vancouver, ISO, and other styles

43

Nakagama, Tatsuro, Masaaki Yamada, and Shigetaka Suzuki. "Screening of chemiluminescent systems for the determination of some biologically important organic compounds." Analytica Chimica Acta 217 (1989): 371–76. http://dx.doi.org/10.1016/s0003-2670(00)80420-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Antropova, Irina G., Aleksandra A. Revina, Elena S. Kurakina, and Eldar P. Magomedbekov. "Radiation Chemical Investigation of Antioxidant Activity of Biologically Important Compounds from Plant Materials." ACS Omega 5, no. 11 (March 11, 2020): 5976–83. http://dx.doi.org/10.1021/acsomega.9b04335.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Dembitsky, Valery M., Dmitri O. Levitsky, Tatyana A. Gloriozova, and Vladimir V. Poroikov. "Acetylenic Aquatic Anticancer Agents and Related Compounds." Natural Product Communications 1, no. 9 (September 2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100914.

Full text

Abstract:

Although acetylenes are common as components of terrestrial plants, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from aquatic organisms: cyanobacteria, algae, fungi, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV inhibitory, and immuno-suppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities of more than 230 acetylenic metabolites isolated from aquatic organisms. With the computer program PASS some additional biological activities are also predicted, which point toward possible new applications of these compounds. This review emphasizes the role of aquatic acetylenic compounds as an important source of leads for drug discovery.

APA, Harvard, Vancouver, ISO, and other styles

46

Bhabhor, Falguni, K. Satish, Hiren Variya, and Vikram Panchal. "Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-Clubbed Chalcone Derivatives." International Letters of Chemistry, Physics and Astronomy 63 (January 2016): 83–89. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.63.83.

Full text

Abstract:

In this present work base catalyzed method used for formation of Chalcone of (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) reacted with derivatives of S-benzo [d] thiol-2yl-2-chloroethanethioate (Ia-f) resulted in formation of corresponding derivatives of (E)-S-benzo [d] thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (IIIa-f) was confirmed by spectral characterization such as IR,1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel Gram-positive and Gram-negative bacteria as well as fungi.

APA, Harvard, Vancouver, ISO, and other styles

47

Bhabhor, Falguni, K. Satish, Hiren Variya, and Vikram Panchal. "Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-Clubbed Chalcone Derivatives." International Letters of Chemistry, Physics and Astronomy 63 (January 4, 2016): 83–89. http://dx.doi.org/10.56431/p-8hbuet.

Full text

Abstract:

In this present work base catalyzed method used for formation of Chalcone of (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) reacted with derivatives of S-benzo [d] thiol-2yl-2-chloroethanethioate (Ia-f) resulted in formation of corresponding derivatives of (E)-S-benzo [d] thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (IIIa-f) was confirmed by spectral characterization such as IR, 1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel Gram-positive and Gram-negative bacteria as well as fungi.

APA, Harvard, Vancouver, ISO, and other styles

48

Kraszewski, Adam, and Jacek Stawinski. "H-Phosphonates: Versatile synthetic precursors to biologically active phosphorus compounds." Pure and Applied Chemistry 79, no. 12 (January 1, 2007): 2217–27. http://dx.doi.org/10.1351/pac200779122217.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Kucherenko, L. I., T. S. Brytanova, and A. S. Hotsulia. "Synthesis, molecular docking, and ADME analysis of a series of 4-amino-3,5-dimethyl-1,2,4-triazole derivatives." Current issues in pharmacy and medicine: science and practice 16, no. 2 (July 3, 2023): 147–53. http://dx.doi.org/10.14739/2409-2932.2023.2.281039.

Full text

Abstract:

The heterocyclic system of 1,2,4-triazole enables the successful creation of promising biologically active compounds. By creating a range of derivatives based on 4-amino-3,5-dimethyl-1,2,4-triazole, the spectrum of potential biologically active compounds can be expanded. The aim of the work was the synthesis and in silico justification of the prospects for the search for biologically active compounds among 4-amino-3,5-dimethyl-1,2,4-triazole derivatives. Materials and methods. The work uses modern methods for synthesizing organic compounds, followed by confirmation of their individuality and structure through the analysis of physical-chemical parameters and spectroscopic techniques such as 1H NMR, IR spectroscopy, elemental analysis, and chromatography-mass spectrometry. To assess the similarity of the synthesized compounds to medicinal products, the SwissADME online tool was employed. The probability of impact on a number of enzyme systems (cyclooxygenase-2, lanosterol 14α-demethylase, anaplastic lymphoma kinase) was estimated using molecular docking. Results. A series of newly synthesized derivatives of 4-amino-3,5-dimethyl-1,2,4-triazole was obtained, and the synthesis conditions were optimized and their structures were confirmed. It was determined that there is a high probability of influencing lanosterol 14α-demethylase, highlighting the significance of further research on the antifungal activity of the synthesized compounds. Additionally, the potential influence on the activity of cyclooxygenase-2 and anaplastic lymphoma kinase was discovered. However, the probability of exhibiting the corresponding activities, namely anti-inflammatory and anti-cancer, is low. Physical indicators, parameters of pharmacokinetics, and drug-likeness are important, which determines the prospects of creating biologically active substances based on the synthesized series of compounds. Conclusions. A series of 4-((R-iden)amino)-3,5-dimethyl-1,2,4-triazoles were synthesized, and their general physical-chemical properties were determined. The overall potential for creating innovative biological products based on these compounds was assessed using in silico methods for predicting the activity of substances.

APA, Harvard, Vancouver, ISO, and other styles

50

Pejic, Natasa, Slobodan Anic, and Ljiljana Kolar-Anic. "Analytical applications of oscillatory chemical reactions: Determination of some pharmaceuticaly and biologically important compounds." Chemical Industry 66, no. 2 (2012): 153–64. http://dx.doi.org/10.2298/hemind110912081p.

Full text

Abstract:

Novel analytical methods for quantitive determination of analytes based on perturbations of oscillatory chemical reactions realized under open reactor conditions (continuosly fed well stirred tank reactor, CSTR), have been developed in the past twenty years. The proposed kinetic methods are generally based on the ability of the analyzed substances to change the kinetics of the chemical reactions matrix. The unambiguous correlation of quantitative characteristics of perturbations, and the amount (concentration) of analyte expressed as a regression equation, or its graphics (calibration curve), enable the determination of the unknown analyte concentration. Attention is given to the development of these methods because of their simple experimental procedures, broad range of linear regression ( 10-7 10-4 mol L-1) and low limits of detection of analytes ( 10-6 10-8 mol L1, in some cases even lower than 10-12 mol L-1). Therefore, their application is very convenient for routine analysis of various inorganic and organic compounds as well as gases. This review summarizes progress made in the past 5 years on quantitative determination of pharmaceutically and biologically important compounds.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Biologically important compounds'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles