Dissertations / Theses on the topic 'Biological substance'
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DARMAN, PAUL STEWART. "THE SYNTHESIS AND BIOLOGICAL EVALUATION OF ALPHA-MELANOTROPIN AND SUBSTANCE P PEPTIDE ANALOGUES (STRUCTURE, FUNCTION)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/187929.
Full textLindsay, Gregory W. "Enhanced Renal Sympathetic and Cardiovascular Responses to Substance P in Hypertension." Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2718.
Full textBondarenko, I. S., О. Г. Аврунін, O. Gryshkov, B. Glasmacher, S. I. Bondarenko, A. V. Krevsun, and M. V. Rakhimova. "Acoustomagnetic detection of magnetic nanoparticles in a model." Thesis, The International Journal of Artificial Organs, 2019. http://openarchive.nure.ua/handle/document/9878.
Full textLandis, Geoffrey Carrothers. "Synthesis and biological activities of tachykinin and opioid-related compounds, synthesis of unusual amino acids, and the investigations into the smooth muscle pharmacology of tachykinins." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184656.
Full textPlant, Christopher P. "NICOTINE AND METHYLPHENIDATE CHORNIC EXPOSURE ON ADULT CANNABINOID RECEPTOR AGONIST (CP 55,940) PLACE CONDITIONING IN MALE RATS." CSUSB ScholarWorks, 2016. https://scholarworks.lib.csusb.edu/etd/339.
Full textBotros, Milad. "Characterization of Substance P (SP) Aminoterminal SP (1-7) Binding in Brain Regions and Spinal Cord of the Male Rat : Studies on the Interaction with Opioid Related Pathways." Doctoral thesis, Uppsala universitet, Avdelningen för biologisk beroendeforskning, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9401.
Full textPloux, Olivier. "Synthèse d'analogues cycliques de la substance P : études biochimiques et structurales." Paris 6, 1986. http://www.theses.fr/1986PA066076.
Full textShamgochian, Maureen. "The Stimulation of Luteinizing Hormone Secretion from Anterior Pituitary Cells in Culture by Substance P: A Dissertation." eScholarship@UMMS, 1990. https://escholarship.umassmed.edu/gsbs_diss/129.
Full textSkog, Manfred. "Kvantifiering av näringsflöden i Recirkulerande Akvakultur (RAS) och nätkasseodling av lax (Salmo salar)." Thesis, Linköpings universitet, Biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-149624.
Full textSherwood, Alexander M. "Design, Synthesis and Biological Evaluation of Novel Compounds with CNS-Activity Targeting Cannabinoid and Biogenic Amine Receptors." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1831.
Full textStrickland, Justin Charles. "EXAMINING THE UTILITY OF BEHAVIORAL ECONOMIC DEMAND IN ADDICTION SCIENCE." UKnowledge, 2019. https://uknowledge.uky.edu/psychology_etds/154.
Full textHallberg, Mathias. "Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5745.
Full textBatten, Seth Richard. "MEASURING GLUTAMATE AND OXYGEN IN BRAIN REWARD CIRCUITS IN ANIMAL MODELS OF COCAINE ABUSE AND DECISION-MAKING." UKnowledge, 2019. https://uknowledge.uky.edu/psychology_etds/165.
Full textREYDAMS, Louise Hallal. "Substâncias psicoativas e ritmo biológico em uma amostra comunitária de jovens." Universidade Catolica de Pelotas, 2018. http://tede.ucpel.edu.br:8080/jspui/handle/jspui/728.
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Substance use disorder is related to numerous mental and physical health problems, associated with several functional impairments that affect several aspects of the life of the individual with the disorder. The objective of this study was to evaluate the relationship between psychoactive substances and biological rhythm in a community sample of young people. It is a cross-sectional population-based study with adults aged 24 to 30 years living in the urban area of the city of Pelotas, RS. The sample selection was performed by multi-stage conglomerates. Socio-demographic data were collected from the sample and substance abuse or dependence was assessed through the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), as well as the biological rhythm was evaluated through the Biological Rhythm Interview of Assessment Neuropsychiatry (BRIAN). A total of 1241 subjects were evaluated. The prevalence of substance use disorders in the sample was as follows: alcohol 14.1% (n=175), tobacco 30.8% (n=382), cannabis 10.5% (n=130), cocaine/crack 8.4% (n=104) and other psychoactive substance use disorder 9.2% (n=114). In the model of linear regression adjustment, alcohol use disorder was able to predict change in sleep/social pattern (p<0.001), activity (p=0.024), eating pattern (p=0.049) and overall rhythm (p<0.001). Other psychoactive substance use disorder was also predictive of changes in the sleep/social pattern (p <0.001), activity (p<0.001), eating pattern (p<0.001) and overall rhythm (p<0.001). Our findings suggest that individuals with alcohol and other psychoactive use disorders presented greater changes in sleep/social patterns, activity and food patterns, as well as greater disruptions in maintaining the overall biological rhythm.
O transtorno por uso de substâncias está relacionado a inúmeros problemas de saúde mental e física, associado a diversos prejuízos funcionais que afetam diversos aspectos da vida do indivíduo portador do transtorno. O objetivo deste estudo foi avaliar a relação entre substâncias psicoativas e ritmo biológico em uma amostra comunitária de jovens. Trata-se de um estudo transversal de base populacional com adultos de 24 a 30 anos de idade residentes da zona urbana da cidade de Pelotas-RS. A seleção amostral foi realizada por conglomerados com múltiplos estágios. Foram coletados dados sócio-demográfico da amostra e o abuso ou dependência de substâncias foi avaliado através do Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), bem como o ritmo biológico foi avaliado através da Biological Rhythm Interview of Assessment Neuropsychiatry (BRIAN). Foram avaliados 1241 sujeitos. As prevalências de transtornos por uso de substâncias na amostra foram as seguintes: álcool 14,1% (n=175), tabaco 30,8% (n=382), cannabis 10,5% (n=130), cocaína/crack 8,4% (n=104) e uso de outra substância psicoativas 9,2% (n=114). No modelo de ajuste por Regressão Linear, transtorno por uso de álcool foi capaz de predizer mudança no padrão de sono/social (p<0,001), atividade (p=0,024), alimentação (p=0,049) e ritmo global (p<0,001). Além disso, o transtorno por uso de outras substâncias psicoativas também foi capaz de predizer mudanças no padrão de sono/social (p<0,001), atividade (p<0,001), alimentação (p<0,001) e ritmo global (p<0,001). Nossos sugerem que os indivíduos com transtorno por uso de álcool e outras substâncias psicoativas apresentaram maiores alterações no padrão de sono/social, na atividade e no padrão alimentar, bem como, apresentaram maiores disrupturas na manutenção do ritmo biológico global.
Zhao, Renzun. "Management strategy of landfill leachate and landfill gas condensate." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77186.
Full textPh. D.
Al-Chalabi, F. T. "Biological interactions between growth regulating substances and herbicides in weed control." Thesis, Bangor University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233243.
Full textNisbet, Lorna A. "The analysis and detection of new psychoactive substances in biological matrices." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7213/.
Full textArunotayanun, W. "Chemical and biological studies on natural and synthetic Novel Psychoactive Substances." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1432658/.
Full textMagnusson, Kristina. "The Impact of Nandrolone Decanoate on Neuropeptidergic Mechanisms Related to Cognition, Aggression, Reward and Dependence." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107483.
Full textÖstlund, Eva. "Growth factors and vasoactive substances in intrauterine growth restriction and preeclampsia /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-5046-6/.
Full textKarlsson, Frida. "Estrogenic Substances in Plastic Bottles." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37117.
Full textVi lever i en tid där plast och plastprodukter finns överallt runt omkring oss och har en stor del i vår vardag. Många kemiska ämnen kan återfinnas i plastprodukter, såsom plastflaskor, och kan ha en stor inverkan inte bara på den växande kroppen hos barn utan även ge endokrina störningar hos vuxna människor. Detta kan till exempel ske genom att ämnen kan binda till och påverka östrogenreceptorn (ER) i cellerna. Den här studien fokuserar på plastflaskor gjorda av olika typer av plast och med varierande storlek och användningsområde. Syftet med studien var att se huruvida några östrogena substanser kunde lakas ut i vatten som förvarades i flaskorna. Flaskorna fylldes med avjoniserat vatten och förvarades i 70°C i 72 timmar. Östrogenaktiviteten i vattnet mättes sedan i en cellbaserad testmetod, kallad U2OS-luc assay, där den samlade biologiska effekten av alla östrogena ämnen kan mätas. Effekten uttrycks som bioassay-derived estradiol equivalents (Bio-EEQ). Vatten från polypropenflaskan (PP) gav det högsta Bio-EEQ på 0,5 pg/ml medan högdensitetspolyeten (HDPE) gav 0,3 pg/ml och polyetylentereftalat (PET) ett Bio-EEQ på 0,04 pg/ml. Dessa resultat indikerar att plastflaskorna läcker ut små mängder östrogenlika ämnen. Vidare studier behöver göras för att avgöra huruvida detta läckage utgör någon risk för människor.
Villafranca, Steven Wayne. "The effect of early psychostimulant treatment on abuse liability and dopamine receptors." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2824.
Full textSifi, Bouaziz. "Valorisation des écorces de chêne (quercus pedunculata) et de leurs substances hydrosolubles." Nancy 1, 1987. http://www.theses.fr/1987NAN10108.
Full textEsaka, Yukihiro. "DEVELOPMENT OF SEPARATION METHODS FOR BIOLOGICAL SUBSTANCES BY CAPILLARY ELECTROPHORESIS AND LIQUID CHROMATOGRAPHY." Kyoto University, 1995. http://hdl.handle.net/2433/78069.
Full textMignogna, Kristin. "Genome-Wide Systems Genetics of Alcohol Consumption and Dependence." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5946.
Full textBeard, Daniel A. "Advection and diffusion of substances in tissues containing complex vascular networks /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8015.
Full textHale, Kerry Anne. "The formation, synthesis and reactions of humic polymers in chemical and biological systems." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329937.
Full textShort, Douglas Mackay. "Chemical mechanisms underlying some biological reactions mediating the cytotoxicity and therapeutic potential of nitric oxide." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14102.
Full textØrskov, Christensen Janne. "Evaluation of an in vitro lipid digestion model : testing poorly soluble drug substances and lipid-based formulations /." [Cph.] : Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/jannechristensen.htm.
Full textKumar, Ketan. "Product management framework for the development of automation solutions for biologics drug substance manufacturing." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/126904.
Full textThesis: S.M., Massachusetts Institute of Technology, Department of Chemical Engineering, May, 2020
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 119-122).
This thesis presents a product management framework for the development of innovative manufacturing automation solutions, and the application of this framework to the development of automation for a continuous biomanufacturing platform at Amgen. A recently formed team at Amgen - Next Gen Automation (Drug Substance)(NGA(DS)) - is working to develop innovative automation solutions that support Amgen's strategic initiatives. Being an innovation team, NGA(DS) faces uncertainty regarding what aspects of the existing process are best suited to be improved using automation and what the best automation solutions are to achieve these results. The framework presented in this thesis provides NGA(DS) a methodology to develop useful solutions in the presence of this uncertainty. Supporting automation development for the continuous biomanufacturing platform is one of the work streams of NGA(DS), and was used as a case study for the development of the product management framework. Several prominent innovation and product management frameworks were lever-aged in the development of the framework for this project, including Lean Startup and Disciplined Entrepreneurship. As recommended by the sources studied, this project modelled innovation as a collaborative and iterative process of testing hypotheses regarding the value of the product being developed. Specific tools and concepts were applied from the source frameworks, as relevant to the teams's needs. The framework developed in this project consisted of two phases - Opportunity Analysis and Solution Development - with multiple data collection and analysis activities in each phase. Results from the activities were validated through reviews by the NGA(DS) team leadership and other relevant Subject Matter Experts within Amgen. The framework developed in this project is intended to guide future decision making for product development activities by NGA(DS).
by Ketan Kumar.
M.B.A.
S.M.
M.B.A. Massachusetts Institute of Technology, Sloan School of Management
S.M. Massachusetts Institute of Technology, Department of Chemical Engineering
Zouzou, Michel. "Contribution à l'étude de quelques effets de l'acide borique in situ (Coleoptile de blé, hypocotyle de tournesol; Comparaison avec les acides phenylacétique et indolyl-3 acétique) et in vivo (développement de la plantule de tournesol; Croissance." Besançon, 1988. http://www.theses.fr/1988BESA2035.
Full textMännlová, Adriana. "Studium biologické aktivity superabsorpčních polymerů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-316167.
Full textDunand, Christophe. "Perception d'un signal xyloglucane par des protéines membranaires et mise en évidence d'activité xyloglucane endotransglycosylane induite." Université Joseph Fourier (Grenoble ; 1971-2015), 1997. http://www.theses.fr/1997GRE10111.
Full textKozelková, Aneta. "Studium botnavosti a biologické aktivity hydrogelů huminových kyselin." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2013. http://www.nusl.cz/ntk/nusl-216989.
Full textGrove, Mette. "Development and characterisation of lipid-based formulations for oral delivery of poorly soluble drug substances /." Cph. : The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, 2006. http://www.dfuni.dk/index.php/Mette_Grove/3071/0/.
Full textHoward, Patricia Ann. "Analysis of mesh strategies for rapid source location in chemical/biological attacks." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0430104-144332.
Full textMitra, Ganguli Tora. "Modulation of Voltage-Gated N-Type Calcium Channels by G Protein-Coupled Receptors Involves Lipids and Proteins: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/389.
Full textMohd, Fauzi Fazlin Binti. "In silico target prediction : applications to traditional medicine and novel psychoactive substances and the extension to biological space." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708743.
Full textSwitalla, Simone [Verfasser]. "Characterization of local respiratory irritation and inflammation after acute exposure to biological and chemical substances in PCLS / Simone Switalla." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2011. http://d-nb.info/1013364341/34.
Full textFlorentin, Irène. "Caracterisation fonctionnelle comparative de substances immunomodulatrices." Paris 6, 1987. http://www.theses.fr/1987PA066374.
Full textZebiri, Ilhem. "Etude phytochimique et biologique de cinq espèces de la flore péruvienne. Evaluation de leurs propriétés antileishmanienne et cytotoxique." Thesis, Reims, 2015. http://www.theses.fr/2015REIMS043/document.
Full textThis work presents the phytochemical study of five Peruvian plants, Myrsine latifolia, M. congesta and M. sessiliflora (Primulaceae ex Myrsinaceae), Poraqueiba sericea (Icacinaceae) and Dendrobangia boliviana (Cardiopteridaceae ex Icacinaceae). The study of the three Myrsine enabled us to isolate eleven compounds already known in the literature which were tested for their antileishmanial (screening of Leishmania promastigotes luminescence) and cytotoxic activities (in vitro test on fibroblasts). The results were negative for both activities. From the stems of Poraqueiba sericea we were able to isolate eleven compounds including six triterpenes, three monodesmosides saponins described for the first time in this plant family and two secoiridoides. Various biological activities have been evaluated for these molecules: leishmanicidal, cytotoxic and anti-elastase activities. Only the last testing has suggested activities for two tripterpénoïdes and the secologanoside. From Dendrobangia boliviana fourteen saponins have been isolated including twelve novel glycosides of the serjanique or phytolaccinique acids. The analysis by LC-NMR allowed us to identify five other saponins with new structures. These compounds were tested for their biological activities and showed no hemolytic activity and three of them showed a cytotoxicity on fibroblasts. The antileishmanial test showed no activity. In bioautography (HPTLC) these saponins showed an interesting potential for different biological activities (tyrosinase, α and β-glucosidase and acetylcholinesterase)
Gupta, Abhinav. "Characterization and treatment of UV quenching substances and organic nitrogen in landfill leachates and thermal hydrolysis/anaerobic digestion centrate." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/22049.
Full textThe study aimed at characterizing landfill leachate and centrate fractions to develop an understanding that might help design on-site treatment methods. Leachates varying in on-site treatment and ages were fractionated on basis of hydrophobic nature. Humic substances were the major UV light quenching fractions. Majority of the humic substances were > 1 kDa molecular weight cut off (MWCO) indicating that membrane treatment might be effective for UV quenching substances removal. UV absorbing substances were found to be more bio-refractory than organic carbon. Significant decrease in humic substances with long term landfilling indicated that age was important in determining the potential for leachates to impact the UV disinfection. Organic nitrogen was observed to be hydrophilic in nature (mostly < 1 kDa). Proteins which are easily biodegradable contributed around one-third of the organic nitrogen.
For thermal hydrolysis centrate, the optimum treatment depended on particle size and hydrophobic nature. Biological treatment was observed to be more effective for the removal of
organic matter and UV254 quenching substances for fractions < 300 kDa. Biological treatment had little impact on organic nitrogen. Coagulation-flocculation is an effective treatment for higher molecular weight (MW) fractions whereas a membrane bioreactor would be more suitable for smaller MW fractions.
Master of Science
David, Jan. "Produkce, charakterizace a návrh aplikací regenerovaných huminových kyselin." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2011. http://www.nusl.cz/ntk/nusl-233322.
Full textJohnson, Robert Jean. "Plant growth regulators : an alternative to frequent mowing /." Thesis, Monterey, California : Naval Postgraduate School, 1990. http://handle.dtic.mil/100.2/ADA232051.
Full textThesis Advisor(s): Carrick, Pual M. "June 1990." Description based on signature page. DTIC Identifier(s): Plant growth regulators, growth indicators. Author(s) subject terms: Plant growth regulators, growth indicators. Includes bibliographical references (p. 39-40). Also available online.
Fernandez, Nadia. "Separation et etude des composants de liaison cellulaires fixant les substances aromatiques polycycliques." Toulouse 3, 1987. http://www.theses.fr/1987TOU30247.
Full textMiller, Mark W. "Optimizing high-rate activated sludge: organic substrate for biological nitrogen removal and energy recovery." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/78208.
Full textPh. D.
Buś, Tanja [Verfasser], Ulrich Sigmar [Gutachter] Schubert, and Thomas [Gutachter] Heinze. "The enhanced delivery of biologically active substances by tailor-made polymers / Tanja Buś ; Gutachter: Ulrich Sigmar Schubert, Thomas Heinze." Jena : Friedrich-Schiller-Universität Jena, 2019. http://d-nb.info/1206605014/34.
Full textКіндя, Валерій Ілліч, Валерий Ильич Киндя, and Valerii Illich Kindia. "Концентрація деяких біологічно активних сполук в соєвій олії, отриманой методом пересування з бобів, вирощених в умовах Сумської області." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32161.
Full textSloss, Ian. "The effects of ethanol on memory and neuroplasticity in a vertebrate and an invertebrate model of learning." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/65381/.
Full textBallade, Tosco Armelle. "Identification et caractérisation par spectrométrie de masse de substances à activités biologiques produites par des souches de BacillusS." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14240.
Full textCompounds produced by Bacillus bacteria present a major interest because of their biological activities. The aim of this work was to develop a reliable analytical methodology to extract these compounds, and to characterize them by mass spectrometry and by their biological activities. A first approach by MALDI-ToF mass spectrometry doesn’t give satisfactory results because of strong spectral suppression effects. Therefore, we have designed a second strategy which combined two analytical technologies. First, compounds and lipopeptides families were separated by analytical liquid chromatography and analysed by ESI-IT. Then, collected fractions were characterized by MALDI-Q-ToF (and ESI-Q-ToF) in order to determine accurate mass measurements and obtain complementary product ion spectra. This process led us to establish identification criteria of compounds and lipopeptides families which have known structures. This characterization is based of retention times in chromatography, accrurate mass measurements and fragmentation schemes. We have achieved the same experiments with non identified compounds and then assessed their biological activity by agar well diffusion test.This strategy allows to obtain a screening of whole of the biomolecules produced by bacillus strains and establishes a link between structure and biological activity. This methodology, designed for cultures in liquid medium, was then adapted to cultures in Petri disches in order to analyse compounds producted at the bacterial colony scale