Journal articles on the topic 'Biological psychology not elsewhere classified'
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Koretzky, Martin B., and Alexis S. V. Rosenoer. "MMPI Assessment of Posttraumatic Stress Disorder among Alcoholic Vietnam Veterans." Psychological Reports 60, no. 2 (April 1987): 359–65. http://dx.doi.org/10.2466/pr0.1987.60.2.359.
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One hundred Vietnam-era male veterans in a Veterans Administration. 28-day inpatient alcohol treatment program were classified into combat and noncombat groups according to whether they served in Vietnam or elsewhere during the Vietnam conflict. The MMPI scores of the two groups were compared according to a diagnostic decision-rule developed by Keane, Malloy, and Fairbank in 1984 for posttraumatic stress disorder. Chi-squared analysis showed that the combat group passed the decision-rule in significantly higher numbers than the noncombat group. The results provide evidence that the F-2-8 decision-rule to determine this diagnosis applies to alcoholic as well as nonalcoholic populations.
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Cabanac, Michel. "The evolutionary point of view: Rationality is elsewhere." Behavioral and Brain Sciences 19, no. 2 (June 1996): 322. http://dx.doi.org/10.1017/s0140525x00042898.
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AbstractBaron has provided some examples of nonconsequentialism in decision making and describes them as biases; these may be the remnants of the biological origin of decision making. One may argue that decisions are made on the basis not of rationality but affective processes. Behavior follows the trend toward maximizing pleasure. This mechanism might explain apparent nonconsequentialism.
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Thomson, Kaivo, and Anthony Watt. "Investigating cognitive style differences in the perception of biological motion associated with visuospatial processing." Polish Psychological Bulletin 44, no. 1 (March 1, 2013): 50–55. http://dx.doi.org/10.2478/ppb-2013-0006.
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Abstract The purpose of the study was to compare the visuospatial decision-making error scores related to the perception of biological motion of individuals categorized as field dependent or field independent. A sample of 69 participants aged 18-27 years (M = 21.91, SD = 2.39) that included 33 males and 36 females completed the experiment. Cognitive style was assessed using the Group Embedded Figure Test. Perception of biological motion was evaluated using two different point-light stimuli developed from video images of a ballet dancer’s performance of a correct and incorrect turn in the fifth position. The results showed that individuals classified as field independent made significantly fewer visuospatial processing errors. The findings are considered and discussed in relation to theoretical perspectives associated with both cognitive processing and cognitive style.
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Zeki, S., O. R. Goodenough, and Oliver R. Goodenough. "Responsibility and punishment: whose mind? A response." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 359, no. 1451 (November 29, 2004): 1805–9. http://dx.doi.org/10.1098/rstb.2004.1548.
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Cognitive neuroscience is challenging the Anglo-American approach to criminal responsibility. Critiques, in this issue and elsewhere, are pointing out the deeply flawed psychological assumptions underlying the legal tests for mental incapacity. The critiques themselves, however, may be flawed in looking, as the tests do, at the psychology of the offender. Introducing the strategic structure of punishment into the analysis leads us to consider the psychology of the punisher as the critical locus of cognition informing the responsibility rules. Such an approach both helps to make sense of the counterfactual assumptions about offender psychology embodied in the law and provides a possible explanation for the human conviction of the existence of free will, at least in others.
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Lesieur, Henry R., and Richard J. Rosenthal. "Pathological gambling: A review of the literature (prepared for the American Psychiatric Association task force on DSM-IV committee on disorders of impulse control not elsewhere classified)." Journal of Gambling Studies 7, no. 1 (1991): 5–39. http://dx.doi.org/10.1007/bf01019763.
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Edwards, Robert R., Claudia Campbell, Robert N. Jamison, and Katja Wiech. "The Neurobiological Underpinnings of Coping With Pain." Current Directions in Psychological Science 18, no. 4 (August 2009): 237–41. http://dx.doi.org/10.1111/j.1467-8721.2009.01643.x.
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The biopsychosocial model treats pain as resulting from a complex interaction of biological, psychological, and social factors. Individual differences in approaches to coping with pain-related symptoms are important determinants of pain-related outcomes, and are often classified under the “psychological” category within the biopsychosocial model. However, engagement in various cognitive, affective, and behavioral pain-coping strategies appears to exert biological effects, which we review here. Pain-coping activities such as catastrophizing, distracting oneself from pain sensations, or reappraisal of pain may exert effects on activity in a variety of pain-processing and pain-modulatory circuits within the brain, as well affect the functioning of neuromuscular, immune, and neuroendocrine systems. The interface between pain-related neurobiology and the use of specific pain-coping techniques represents an important avenue for future pain research.
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Lyon, Pamela. "Of what is “minimal cognition” the half-baked version?" Adaptive Behavior 28, no. 6 (September 6, 2019): 407–24. http://dx.doi.org/10.1177/1059712319871360.
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“Minimal cognition” is used in certain sectors of the cognitive sciences to make a kind of ontological claim that may be unique in the biological sciences: that a function operating in organisms living today is not a fully fledged version of that function (the nature of which remains unspecified), but, rather, exhibits the minimal requirements for whatever it is, properly conceived. Evidence suggests that elsewhere in the life sciences, deployment of minimizing qualifiers relative to a biological function appears largely restricted to two scenarios: first, attenuated functioning and, second, evolution of the function, real or synthetic. The article argues that “minimal cognition” and “proto-cognitive” were introduced at the turn of this century by cognitive researchers seeking to learn directly from evolved behavior, ecology and physiology. A terminological straitjacket imposed on the central object of cognitive science at its beginning necessitated the move. An alternative terminology is proposed, based on a phyletically neutral definition of cognition as a biological function; a candidate mechanism is explored; and a bacterial example presented. On this story, cognition is like respiration: ubiquitously present, from unicellular life to blue whales and every form of life in between, and for similar reasons: staying alive requires it.
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Ziegler, Matthias, Stefan Schmukle, Boris Egloff, and Markus Bühner. "Investigating Measures of Achievement Motivation(s)." Journal of Individual Differences 31, no. 1 (January 2010): 15–21. http://dx.doi.org/10.1027/1614-0001/a000002.
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After a long debate there is now growing agreement that implicit and explicit achievement motivation can be seen as distinct constructs. One of their major differences lies in their predictive validity, which supposedly differs depending on the setting. Empirical evidence exists to the effect that different explicit measures based on different theoretical concepts build one construct. For implicit measures, however, such evidence is lacking. Thus, scores on three implicit and three explicit achievement motivation measures, an intelligence test, and a Big 5 questionnaire were obtained (N = 150) as well as two criteria. The explicit achievement motivation measures were classified as being based either on Murray’s or on McClelland’s theory. Results replicate the idea of a common construct for explicit measures but not for implicit measures. The assumed predictions did not occur for all tests and disappeared when controlling for intelligence.
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DeVivo, Renée, Lauren Zajac, Asim Mian, Anna Cervantes-Arslanian, Eric Steinberg, Michael L. Alosco, Jesse Mez, Robert Stern, and Ronald Killany. "Differentiating Between Healthy Control Participants and Those with Mild Cognitive Impairment Using Volumetric MRI Data." Journal of the International Neuropsychological Society 25, no. 08 (May 27, 2019): 800–810. http://dx.doi.org/10.1017/s135561771900047x.
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AbstractObjective:To determine whether volumetric measures of the hippocampus, entorhinal cortex, and other cortical measures can differentiate between cognitively normal individuals and subjects with mild cognitive impairment (MCI).Method:Magnetic resonance imaging (MRI) data from 46 cognitively normal subjects and 50 subjects with MCI as part of the Boston University Alzheimer’s Disease Center research registry and the Alzheimer’s Disease Neuroimaging Initiative were used in this cross-sectional study. Cortical, subcortical, and hippocampal subfield volumes were generated from each subject’s MRI data using FreeSurfer v6.0. Nominal logistic regression models containing these variables were used to identify subjects as control or MCI.Results:A model containing regions of interest (superior temporal cortex, caudal anterior cingulate, pars opercularis, subiculum, precentral cortex, caudal middle frontal cortex, rostral middle frontal cortex, pars orbitalis, middle temporal cortex, insula, banks of the superior temporal sulcus, parasubiculum, paracentral lobule) fit the data best (R2= .7310, whole model test chi-square = 97.16,p< .0001).Conclusions:MRI data correctly classified most subjects using measures of selected medial temporal lobe structures in combination with those from other cortical areas, yielding an overall classification accuracy of 93.75%. These findings support the notion that, while volumes of medial temporal lobe regions differ between cognitively normal and MCI subjects, differences that can be used to distinguish between these two populations are present elsewhere in the brain.
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Clack, Samuel, and Tony Ward. "The Classification and Explanation of Depression." Behaviour Change 36, no. 1 (February 26, 2019): 41–55. http://dx.doi.org/10.1017/bec.2019.4.
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AbstractIn the field of psychopathology there is still a lack of consensus on how mental disorders, such as depression, should be classified and explained. Many of our current classifications suffer from disorder heterogeneity and are conceptually vague. While some researchers have argued that mental disorders are better explained from a biological perspective, others have made the case for pluralistic and integrative explanations. Using depression as an extended example, we explore the challenges in classifying and explaining psychopathology. We begin by evaluating the current approaches to classification, including frameworks for what we consider a mental disorder. This is followed by a detailed summary of current explanatory perspectives in psychiatry. The relationship between classification and explanation presents unique theoretical challenges in understanding mental disorders. We suggest that by adjusting our focus from understanding syndromes to clinical phenomena we can advance our understanding of mental disorders.
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Randler, Christoph, Lisa Stadler, Christian Vollmer, and Juan Francisco Diaz-Morales. "Relationship Between Depressive Symptoms and Sleep Duration/Chronotype in Women." Journal of Individual Differences 33, no. 3 (January 2012): 186–91. http://dx.doi.org/10.1027/1614-0001/a000089.
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There are few studies suggesting that chronotype or morningness-eveningness (M/E) is a predictor of depressive symptoms. A sample of 277 women (university students) of a mean age of 22.25 years ± (SD) 2.47 participated in this study. We used the Composite Scale of Morningness to assess circadian typology, the Patient Health Questionnaire (PHQ-9) to assess depressive symptomatology, and – because M/E as well as depressive symptoms are associated with personality – we controlled for personality using a short measure of the Big Five Inventory as well as including a scale to measure hypochondriasis. There were 28 women classified with moderate, one with moderately severe, and three with severe depression. Negative correlations existed between CSM score, average sleep duration, extraversion, conscientiousness, and PHQ-9 scores, and positive correlations between hypochondriasis, neuroticism, and PHQ-9 scores. In a hierarchical regression, the model predicts 28% of variance in the PHQ-9 scores. Personality explained 15%, hypochondriasis accounted for 8%, and sleep duration and M/E added another 5%. The results suggest that the influence of morningness-eveningness (β = –0.102) is weaker than the influence of sleep duration (β = –0.194).
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Kropotov, Juri D. "Functional neuromarkers for neuropsychology." Acta Neuropsychologica 16, no. 1 (March 20, 2018): 1–7. http://dx.doi.org/10.5604/01.3001.0011.6504.
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This article is written to commemorate the 40th year of the scientific career of Professor Maria Pąchalska, Head of the Department of Neuropsychology and Neurorehabilitation at Krakow University, President of the Polish Neuropsychological Society, and the Editor-in-chief of Acta Neuropsychologica, with whom I have been collaborating for over ten years. The subject matter of our work includes the introduction of HBI methodology to clinics and the search for neuromarkers in particular disease entities. What is the new methodology we are talking about? In general, we think of a biomarker (or biological marker) as a characteristic that can be objectively measured and evaluated as an index of normal or pathological biological processes. For disorders of the central nervous system, biomarkers can be classified as clinical, neuroimaging, biochemical or genetic, according to the type of information they provide. Expectations for the development of biomarkers are high, since they could lead to a significant improvement in diagnosing and possibly preventing neurological and psychiatric diseases. Neuroimaging is an array of neuroscience methods that include the techniques of magnetic resonance imaging (MRI), functional MRI (fMRI), and PET (positron emission tomography), as well as Electroencephalogram (EEG) and Magnetoencephalogram (MEG) techniques, such as quantitative EEG (QEEG), event related de/synchronization (ERD/ERS) and event-related potentials (ERPs).
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Jones, Doug. "Looks and Living Kinds: Varieties of Racial Cognition in Bahia, Brazil." Journal of Cognition and Culture 9, no. 3-4 (2009): 247–69. http://dx.doi.org/10.1163/156770909x12489459066309.
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AbstractPsychological research in the USA and elsewhere suggests that race is regarded as an underlying, inherited “essential” trait, like membership in a biological species. Yet Brazil has often been regarded as very different from the USA: as a country in which racial variation is seen as more continuous than categorical, more a matter of appearance than descent. This study tests alternative theories of racial cognition in Bahia, Brazil. Data include racial classification of drawings and photographs, judgments of similarity – dissimilarity between racial categories, ideas about expected and possible race of offspring from inter-racial unions, heritability of racial and non-racial traits, and conservation of race through changes in appearance. The research demonstrates consensus over time in appearance-based classification, yet race is also thought of as an “essential” trait. However, racial essences can be mixed, with a person containing the hereditary potential of multiple races, so that race in Bahia does not define clear-cut groups or discrete “living kinds.” If essentialism is the shared core of folk theories of race, there may be more variability and room for social construction in the categorization of mixed-race individuals.
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Duschek, Stefan, Natalie S. Werner, Gustavo A. Reyes del Paso, and Rainer Schandry. "The Contributions of Interoceptive Awareness to Cognitive and Affective Facets of Body Experience." Journal of Individual Differences 36, no. 2 (April 10, 2015): 110–18. http://dx.doi.org/10.1027/1614-0001/a000165.
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Experience of one’s own body relies on signals arising within the body as well as on exteroceptive information, and on appraisal of cognitive and affective aspects of these signals. The present study investigated the impact of sensitivity to internal signals, that is, interoceptive awareness, on interindividual differences in cognitive and emotional aspects of body experience. Subjects with accurate (n = 30) versus poor (n = 30) interoceptive awareness, classified via a heartbeat perception task, completed the Body Consciousness Questionnaire and the Body Appraisal Inventory. Possible effects of emotional state on body experience were controlled for using measures of mood and anxiety. While the groups did not differ in their emotional state, individuals with accurate cardiac interoceptive awareness exhibited higher subjective sensitivity to bodily sensations and a more positive body image, characterized by stronger body-related self-confidence, greater satisfaction with physical appearance, greater perceived bodily self-control, as well as reduced hypochondriacal concerns, sexual discontent, and shame. The present findings extend earlier research on the importance of perception of physical cues for emotion, cognition, and behavior regulation. Our results underline the contribution of interoceptive information to body experience, where interindividual differences in the accessibility of such information modulate cognitive and affective facets of body image.
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Harland, R., E. Antonova, G. S. Owen, M. Broome, S. Landau, Q. Deeley, and R. Murray. "A study of psychiatrists' concepts of mental illness." Psychological Medicine 39, no. 6 (December 18, 2008): 967–76. http://dx.doi.org/10.1017/s0033291708004881.
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BackgroundThere are multiple models of mental illness that inform professional and lay understanding. Few studies have formally investigated psychiatrists' attitudes. We aimed to measure how a group of trainee psychiatrists understand familiar mental illnesses in terms of propositions drawn from different models.MethodWe used a questionnaire study of a sample of trainees from South London and Maudsley National Health Service (NHS) Foundation Trust designed to assess attitudes across eight models of mental illness (e.g. biological, psychodynamic) and four psychiatric disorders. Methods for analysing repeated measures and a principal components analysis (PCA) were used.ResultsNo one model was endorsed by all respondents. Model endorsement varied with disorder. Attitudes to schizophrenia were expressed with the greatest conviction across models. Overall, the ‘biological’ model was the most strongly endorsed. The first three components of the PCA (interpreted as dimensions around which psychiatrists, as a group, understand mental illness) accounted for 56% of the variance. Each main component was classified in terms of its distinctive combination of statements from different models: PC1 33% biological versus non-biological; PC2 12% ‘eclectic’ (combining biological, behavioural, cognitive and spiritual models); and PC3 10% psychodynamic versus sociological.ConclusionsTrainee psychiatrists are most committed to the biological model for schizophrenia, but in general are not exclusively committed to any one model. As a group, they organize their attitudes towards mental illness in terms of a biological/non-biological contrast, an ‘eclectic’ view and a psychodynamic/sociological contrast. Better understanding of how professional group membership influences attitudes may facilitate better multidisciplinary working.
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Valiunas, D., A. Alminaite, J. Staniulis, R. Jomantiene, and R. E. Davis. "First Report of Alder Yellows Phytoplasma in the Eastern Baltic Region." Plant Disease 85, no. 10 (October 2001): 1120. http://dx.doi.org/10.1094/pdis.2001.85.10.1120b.
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Alnus glutinosa (alder) is widespread in Europe and is an important component of biological diversity in natural forest ecosystems in the Baltic Region. In 2000, diseased trees of A. glutinosa exhibiting characteristically phytoplasmal disease symptoms of shoot proliferation and leaf yellowing were observed in Aukstaitija National Park, Lithuania. In other parts of Europe, alder is affected by a phytoplasmal disease known as alder yellows, which is characterized by symptoms that include yellowing and reduced leaf size, die-back of branches, and decline of trees (2,3). Proliferation of shoots has not been previously reported with this disease. An association between alder yellows and infection by a phytoplasma has been reported in A. glutinosa in Germany and Italy, and a phytoplasma has been found in A. glutinosa in France and Hungary (2,4). We examined symptomatic alder from Lithuania using nested polymerase chain reaction (PCR) (1), primed by P1/P7 and followed by R16F2n/R16R2 (F2n/R2), for amplification of phytoplasmal ribosomal (r) DNA. The results indicated the presence of a phytoplasma, designated ALY-L, in the diseased alder. We classified the ALY-L phytoplasma through restriction fragment length polymorphism (RFLP) analysis of 16S rDNA. A 1.2-kbp fragment (F2n-R2 segment) of rDNA, amplified in PCR primed by F2n/R2, was analyzed using single endonuclease enzyme digestion with AluI, MseI, KpnI, HhaI, HaeIII, HpaI, HpaII, RsaI, HinfI, TaqI, Sau3AI, BfaI, and ThaI. On the basis of collective RFLP patterns, phytoplasma ALY-L was classified as a member of group 16SrV (group V, elm yellows group), subgroup C. The amplified 16S rDNA was cloned in Escherichia coli and sequenced, and the sequence was deposited in the GenBank data library (Accession No. AY028789). Nucleotide sequence alignment revealed that 16S rDNA from phytoplasma ALY-L shared 100% sequence similarity with 16S rDNA (GenBank Accession No. Y16387) from a phytoplasma associated with alder yellows (ALY) disease in Italy. The results support the conclusion that a strain of ALY phytoplasma is present in Lithuania. Phytoplasmas belonging to groups 16SrI (aster yellows phytoplasma group) and III (X-disease phytoplasma group) have been found in herbaceous plant species in Lithuania. This report records the first finding of a group V phytoplasma, and the first finding of a phytoplasma in a tree species in the eastern Baltic Region. These findings contribute knowledge about the diversity of phytoplasmas in the Baltic Region and the distribution of ALY phytoplasma in Europe. Apparently, A. glutinosa may be infected by the phytoplasma but not develop obvious disease symptoms, as has been reported elsewhere (3). Thus, it is possible that ALY-L phytoplasma is widespread, but as yet undetected, throughout the geographic range of alder in the Baltic Region. This possibility is supported by the finding of the monophagous leafhopper vector (Oncopsis alni) of ALY phytoplasma throughout Europe (cited in Maixner and Reinert [3]). Further research is needed to assess the impact of phytoplasmal infections such as those by ALY-related phytoplasma strains on trends in biological diversity in the natural forest ecosystems of the Baltic Region and elsewhere in Europe. References: (1) R. Jomantiene et al. Int. J. Syst. Bacteriol. 48:269, 1998. (2) W. Lederer and E. Seemüller. Eur. J. For. Pathol. 21:90, 1991. (3) M. Maixner and W. Reinert. Eur. J. Plant Pathol. 105:87, 1999. (4) R. Mäurer et al. Phytopathology 83:971, 1993.
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Pais, Marcos, Júlia Loureiro, Vagner do Vale, Marcia Radanovic, Leda Talib, Florindo Stella, and Orestes Forlenza. "Heterogeneity of Cerebrospinal Fluid Biomarkers Profiles in Individuals with Distinct Levels of Cognitive Decline: A Cross-Sectional Study." Journal of Alzheimer's Disease 81, no. 3 (June 1, 2021): 949–62. http://dx.doi.org/10.3233/jad-210144.
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Background: Decreased cerebrospinal fluid (CSF) concentrations of the amyloid-β (Aβ), along with increased total (T-tau) and phosphorylated tau protein (P-tau), are widely accepted as core biomarkers of Alzheimer’s disease (AD) pathology. Nonetheless, there are a few remaining caveats that still preclude the full incorporation of AD biomarkers into clinical practice. Objective: To determine the frequency of clinical-biological mismatches in a clinical sample of older adults with varying degrees of cognitive impairment. Methods: 204 participants were enrolled for a cross-sectional assessment and allocated into diagnostic groups: probable AD (n = 60, 29.4%); MCI (n = 84, 41.2%); or normal cognition (NC, n = 60, 29.4%). CSF concentrations of Aβ42, T-tau, and 181Thr-P-tau were determined, and Aβ42/P-tau ratio below 9.53 was used as a proxy of AD pathology. The AT(N) classification was further used as a framework to ascertain the biological evidence of AD. Results: The majority (73.7%) of patients in the AD group had the Aβ42/P-tau ratio below the cut-off score for AD, as opposed to a smaller proportion in the MCI (42.9%) and NC (23.3%) groups. In the latter, 21 subjects (35%) were classified as A+, 28 (46.7%) as T+, and 23 (38.3%) as N + . In the AD group, 66.7%of the cases were classified as A+, 78.3%as T+, and 80%as N+. Conclusion: Analysis of CSF biomarkers was able to discriminate between AD, MCI, and NC. However, clinical-biological mismatches were observed in a non-negligible proportion of cases.
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Bannister, Frank, and Dan Remenyi. "Acts of Faith: Instinct, Value and it Investment Decisions." Journal of Information Technology 15, no. 3 (September 2000): 231–41. http://dx.doi.org/10.1177/026839620001500305.
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Although well over 1000 journal articles, conference papers, books, technical notes and theses have been written on the subject of information technology (IT) evaluation, only a relatively small subset of this literature has been concerned with the core issues of what precisely is meant by the term ‘value’ and with the process of making (specifically) IT investment decisions. All too often, the problem and highly complex issue of value is either simplified, ignored or assumed away. Instead the focus of much of the research to date has been on evaluation methodologies and, within this literature, there are different strands of thought which can be classified as partisan, composite and meta approaches to evaluation. Research shows that a small number of partisan techniques are used by most decision makers with a minority using a single technique and a majority using a mixture of such techniques of whom a substantial minority use a formal composite approach. It is argued that, in mapping the set of evaluation methodologies on to what is termed the investment opportunity space, that there is a limit to what can be achieved by formal rational evaluation methods. This limit becomes evident when decision makers fall back on ‘gut feel’ and other non-formal/rigorous ways of making decisions. It is suggested that an understanding of these more complex processes and decision making, in IT as elsewhere, needs tools drawn from philosophy and psychology.
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Waller, Michael, Rachel F. Buckley, Colin L. Masters, Francis R. Nona, Sandra J. Eades, and Annette J. Dobson. "Deaths with Dementia in Indigenous and Non-Indigenous Australians: A Nationwide Study." Journal of Alzheimer's Disease 81, no. 4 (June 15, 2021): 1589–99. http://dx.doi.org/10.3233/jad-201175.
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Background: The prevalence of dementia is generally reported to be higher among Indigenous peoples. Objective: The rates and coding of dementia mortality were compared between Indigenous and non-Indigenous Australians. Methods: De-identified individual records on causes of death for all people aged 40 years or more who died in Australia between 2006 and 2014 (n = 1,233,084) were used. There were 185,237 records with International Classification of Diseases, Tenth Revision, codes for dementia (Alzheimer’s Disease, vascular dementia, or unspecified dementia) as the underlying cause of death or mentioned elsewhere on the death certificate. Death rates were compared using Poisson regression. Logistic regression was used to assess whether dementia was more likely to be classified as ‘unspecified’ type in Indigenous Australians. Results: The rates of death with dementia were 57% higher in Indigenous Australians, compared to non-Indigenous, relative rate (RR) 1.57, 95% confidence interval (CI) (1.48, 1.66), p < 0.0001. This excess of deaths was highest at ages below 75 (RRs > 2, test for interaction p < 0.0001), and among men (test for interaction p < 0.0001). When the underreporting of Indigenous status on the death certificate was taken into account the relative rate increased to 2.17, 95% CI (2.07, 2.29). Indigenous Australians were also more likely to have their dementia coded as ‘unspecified’ on their death certificate (Odds Ratio 1.92, 95% CI (1.66, 2.21), p < 0.0001), compared to the non-Indigenous group. Conclusion: This epidemiological analysis based on population level mortality data demonstrates the higher dementia-related mortality rate for Indigenous Australians especially at younger ages.
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Laessle, Reinhold, and Esther Hilterscheid. "Stress-Induced Release of Eating-Related Hormones in Young Women Classified as Restrained and Unrestrained Eaters." Neuropsychobiology 78, no. 1 (2019): 27–30. http://dx.doi.org/10.1159/000498866.
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Das, Karumampoyil Sakthidas Anoop, Dhanya Radhamany, and Freerk Molleman. "Community Structure in an Isolated Tropical Forest Biome: One Year of Fruit-Feeding Butterfly Trapping in Four Habitats in the Western Ghats, India." Diversity 15, no. 1 (December 28, 2022): 36. http://dx.doi.org/10.3390/d15010036.
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Insect communities in tropical forests tend to be structured vertically and with respect to tree fall gaps and edges. Furthermore, insect communities vary over time. Insight into such habitat specificity and temporal variation is needed to design and interpret biodiversity surveys and to compare conservation value among habitats. Some aspects of tropical insect community structure, such as the proportion of canopy specialists and temporal variation, vary among biogeographical regions and climatic zones. To date, few regions have been sampled systematically, so generalization remains difficult. We compared fruit-feeding butterfly communities among understory, canopy, natural treefalls, and forest edge, in a tropical forest of the Western Ghats, a strip of rainforest that is isolated from Sundaland, the large rainforest block of South-East Asia. During a yearlong study, we captured 3018 individuals belonging to 32 species and representing 14 genera. While some butterflies were captured in the canopy, no species was significantly more abundant in the canopy than in the understory. This observation was contrary to studies elsewhere in the tropics where 14–55% of the species could be classified as canopy specialists. Even though the largest number of species was captured at forest edges, species diversity was highest in the gaps. The communities at the forest edge differed importantly from those in treefall gaps: at the forest edge, we caught grassland species in addition to the forest species. Larger treefall gaps had higher butterfly abundance than smaller gaps. Both abundance and diversity peaked during the late monsoon season, and all common species in our sample also peaked during this period. The spatiotemporal community structure appears to depend on biogeography (less vertical stratification further from large forest blocks) and climate (more synchrony among species in seasonal abundance when there is a more severe dry season).
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Ross, Colin A. "Ethics of CIA and Military Contracting by Psychiatrists and Psychologists." Ethical Human Psychology and Psychiatry 9, no. 1 (March 2007): 25–34. http://dx.doi.org/10.1891/152315007780493799.
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There have been extensive, systematic violations of human rights by American psychiatrists, psychologists, and neurosurgeons throughout the second half of the twentieth century. These violations have occurred at the leading medical schools with funding from the Central Intelligence Agency (CIA) and the U.S. military. Experiments have involved brain electrodes, LSD, hypnosis, the creation of Manchurian candidates, the development of biological, chemical, and nonlethal weapons, and the implantation of false memories and creation of amnesia. Many experiments were conducted on unwitting civilians and none involved documented consent, adequate outside review, or representation for the experimental subjects, or any meaningful follow-up. Because such still-classified mind control programs are undoubtedly ongoing, there should be disclosure requirements for psychologists and psychiatrists presenting or publishing in subject areas related to their CIA and military contracts, just as there are for civilians in relationships with drug companies.
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Varsadiya, Milan, Tim Urich, Gustaf Hugelius, and Jiří Bárta. "Fungi in Permafrost-Affected Soils of the Canadian Arctic: Horizon- and Site-Specific Keystone Taxa Revealed by Co-Occurrence Network." Microorganisms 9, no. 9 (September 13, 2021): 1943. http://dx.doi.org/10.3390/microorganisms9091943.
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Permafrost-affected soil stores a significant amount of organic carbon. Identifying the biological constraints of soil organic matter transformation, e.g., the interaction of major soil microbial soil organic matter decomposers, is crucial for predicting carbon vulnerability in permafrost-affected soil. Fungi are important players in the decomposition of soil organic matter and often interact in various mutualistic relationships during this process. We investigated four different soil horizon types (including specific horizons of cryoturbated soil organic matter (cryoOM)) across different types of permafrost-affected soil in the Western Canadian Arctic, determined the composition of fungal communities by sequencing (Illumina MPS) the fungal internal transcribed spacer region, assigned fungal lifestyles, and by determining the co-occurrence of fungal network properties, identified the topological role of keystone fungal taxa. Compositional analysis revealed a significantly higher relative proportion of the litter saprotroph Lachnum and root-associated saprotroph Phialocephala in the topsoil and the ectomycorrhizal close-contact exploring Russula in cryoOM, whereas Sites 1 and 2 had a significantly higher mean proportion of plant pathogens and lichenized trophic modes. Co-occurrence network analysis revealed the lowest modularity and average path length, and highest clustering coefficient in cryoOM, which suggested a lower network resistance to environmental perturbation. Zi-Pi plot analysis suggested that some keystone taxa changed their role from generalist to specialist, depending on the specific horizon concerned, Cladophialophora in topsoil, saprotrophic Mortierella in cryoOM, and Penicillium in subsoil were classified as generalists for the respective horizons but specialists elsewhere. The litter saprotrophic taxon Cadophora finlandica played a role as a generalist in Site 1 and specialist in the rest of the sites. Overall, these results suggested that fungal communities within cryoOM were more susceptible to environmental change and some taxa may shift their role, which may lead to changes in carbon storage in permafrost-affected soil.
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Desbiez, A. L. J., D. Kluyber, G. F. Massocato, L. G. R. Oliveira-Santos, and N. Attias. "Spatial ecology of the giant armadillo Priodontes maximus in Midwestern Brazil." Journal of Mammalogy 101, no. 1 (November 20, 2019): 151–63. http://dx.doi.org/10.1093/jmammal/gyz172.
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Abstract The giant armadillo (Priodontes maximus) is the largest living armadillo. This naturally rare and poorly known species is endemic to South America and classified as “Vulnerable” by the IUCN. Here we explored aspects of the spatial ecology of P. maximus in Midwestern Brazil to gain insights on its ecology and biology to support conservation efforts. In 8 years, we identified 50 individuals of P. maximus and monitored 23 of them using telemetry methods. To characterize site fidelity and home range, we fitted individual continuous-time movement models and estimated Autocorrelated Kernel Density Estimates. We built a Structural Equation Model to evaluate how home-range area and daily displacement are related to each other, to sampling effort, and to individual characteristics. We estimated home-range overlap between pairs of different sexes using a bias-corrected Bhattacharyya coefficient. Finally, we formulated a canonical density estimation formula to characterize minimum population density. We gathered a total of 12,168 locations of P. maximus. The best-fitted movement models indicated site fidelity for all individuals and a median adult home-range area of 2,518 ha. Median adult daily displacement was 1,651 m. Home-range area scales positively with daily displacement and daily displacement scales positively with body mass. Median home-range overlap between pairs was low (4%) and adult females presented exclusive home ranges among themselves. Median minimum density was 7.65 individuals per 100 km2 (CI = 5.68–10.19 ind/100 km2). Our results are congruent with characterizing P. maximus as a generally asocial species, most likely promiscuous/polygynous, that establishes large, long-term home ranges, which grants the population a naturally low density. Spatial patterns and biological characteristics obtained in this study can be used to guide future conservation strategies for P. maximus in the Pantanal wetlands and elsewhere.
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Narayan, Angela J., Melissa J. Hagan, Emily Cohodes, Luisa M. Rivera, and Alicia F. Lieberman. "Early Childhood Victimization and Physical Intimate Partner Violence During Pregnancy: A Developmental and Person-Oriented Approach." Journal of Interpersonal Violence 34, no. 1 (April 4, 2016): 3–26. http://dx.doi.org/10.1177/0886260516639261.
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Intimate partner violence (IPV) victimization during pregnancy is a major public health concern, yet little is known about how risk factors for IPV during pregnancy may depend on whether women have histories of victimization dating back to early childhood (ages 0-5 years). This study examined whether risk factors for physical IPV victimization during pregnancy (a pregnancy that was not planned and prenatal substance use) differed for women with versus without early childhood victimization. Participants were 236 ethnically diverse, low-income biological mothers ( M = 30.94 years; 50.0% Latina, 16.9% Caucasian, 13.1% African American, and 16.9% multiracial) of children aged 0 to 6 years. Mothers were classified into four groups based on whether they had experienced early childhood victimization and physical IPV victimization during pregnancy with the target child. Multinomial logistic regressions, controlling for demographic characteristics, examined whether a pregnancy not planned and prenatal substance use predicted group membership. Compared to mothers with early victimization only, mothers with both early childhood victimization and physical IPV during pregnancy were more than 3 times as likely to report that their pregnancy with the target child was not planned. In follow-up analyses, mothers with early victimization and physical IPV during pregnancy also reported higher lifetime parity than mothers with physical IPV during pregnancy but no early victimization. Early childhood victimization may place women on a risk pathway to physical IPV during pregnancy, particularly if the pregnancy is not planned. Prevention and policy efforts should screen women for early childhood victimization to understand risks for physical IPV during pregnancy.
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Zimmerman, William F. "Organisms and Artifacts: Design in Nature and Elsewhere. Life and Mind: Philosophical Issues in Biology and Psychology. By Tim Lewens. A Bradford Book. Cambridge (Massachusetts): MIT Press. $32.00. xi + 183 p; ill.; index. ISBN: 0‐262‐12261‐8. 2004." Quarterly Review of Biology 80, no. 2 (June 2005): 233. http://dx.doi.org/10.1086/433073.
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Venyo, Anthony Kodzo-Grey. "Signet Ring Cell Carcinoma of the Prostate Gland: A Review and Update." Cancer Research and Cellular Therapeutics 5, no. 3 (July 26, 2021): 01–14. http://dx.doi.org/10.31579/2640-1053/082.
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Signet-ring cell carcinoma of the prostate gland (SRCCP) an uncommon and aggressive malignant tumour of the prostate gland which is characterized by histopathology examination features of compression of the nucleus into the form of a crescent by a large cytoplasmic vacuole. SRCCPs that have so far been reported have been either (a) primary tumours, metastatic tumours with the primary tumour elsewhere with the gastro-intestinal tract being the site of the primary tumour but the primary tumour could originate elsewhere, and additionally some reported SRCCPs have been classified as carcinoma of unknown primary. SRCCP could be a pure tumour or a tumour that is contemporaneously associated with other types of tumour including various variants of adenocarcinoma. SRCCP can manifest in various ways including: Incidental finding following prostatectomy that has been undertaken for a presumed benign prostatic hyperplasia, lower urinary tract symptoms, visible and non-visible haematuria, raised levels of serum PSA but some SRCCPs have been diagnosed with normal / low levels of serum PSA, there may be a history of dyspepsia in cases of metastatic signet-ring cell carcinoma in association with contemporaneous primary signet-ring cell carcinoma of the stomach or there may be a past history of surgical treatment for signet-ring cell carcinoma of the gastrointestinal tract, or bleeding from the gastrointestinal tract in cases of upper gastrointestinal tract and rectal bleeding as well as change in bowel habit for primary tumours of the anorectal region, retention of urine, and rarely a rectal mass in the case of SRCCP with an anorectal primary tumour. In order to exclude a primary signet ring cell carcinoma elsewhere, a detailed past medical history is required as well as radiology imaging including contrast – enhanced computed tomography (CECT) scan and contrast-enhanced magnetic resonance imaging (CEMRI) scan as well as upper gastrointestinal endoscopy and colonoscopy to exclude a primary lesion within the gastrointestinal tract. Diagnosis of SRCCP requires utilization of the histopathology and immunohistochemistry examination features of prostate biopsy, prostatic chips obtained from trans-urethral resection of prostate specimen or radical prostatectomy specimen. SRCCPs upon immunohistochemistry staining studies tend to show tumour that tend to exhibit positive staining for the following tumour markers as follows: PSA – positive staining for PSA has been variable in some studies, AE1/AE3, CAM 5.2, Ki-67 with a mean of 8%, PAS-diastase, Mucicarmine (50%), Alcian blue (60%), Alpha-methyl-acyl coenzyme A racemase (P504S), and Cytokeratin 5/6. SRCCPs also tend to exhibit negative staining for: Bcl2 (rare positive), and CEA (80%). Traditionally the treatment of Primary Signet-Ring Cell Carcinoma of the Prostate Gland has tended to be similar to the treatment of the traditional adenocarcinoma of the prostate gland which does include: hormonal treatment, radiotherapy, and surgery. Nevertheless, considering that primary SRCCPs and metastatic SRCCPs that have been reported in the literature have generally tended to be associated with an aggressive biological behaviour, even though there is no consensus opinion on the treatment of the disease it would be strongly recommended that these tumours that tend to be associated with rapid progress of the disease and poor survival there is an urgent need to treat all these tumours with aggressive surgery including radical prostatectomy plus adjuvant therapies including: radical radiotherapy, combination chemotherapy, selective prostatic angiography and super-selective embolization of the artery feeding the tumour including intra-arterial infusion of chemotherapy agents directly to the tumour, radiofrequency ablation of the tumour as well as irreversible electroporation of the tumour which should form part of a global multicentre study of various treatment options. With regard to metastatic signet-ring cell carcinomas of the prostate gland with a contemporaneous primary tumour elsewhere the primary tumour should also be treated by radical and complete excision of the primary tumour plus radical surgery and aggressive adjuvant therapy. Considering that SRCCPs have tendered not to respond well to available chemotherapy agents, there is need for urologists, oncologists, and pharmacotherapy research workers to identify new chemotherapy medicaments that would more effectively and safely destroy signet-ring cell tumours in order to improve upon the prognosis.
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Wallin, Anders, Veronica Milos, Magnus Sjögren, Leonardo Pantoni, and Timo Erkinjuntti. "Classification and Subtypes of Vascular Dementia." International Psychogeriatrics 15, S1 (July 2003): 27–37. http://dx.doi.org/10.1017/s1041610203008937.
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Vascular dementia (VaD) is a heterogeneous entity with a large clinicopathological spectrum. It has been classified and subclassified in many different ways. The difficulty in identifying the various subtypes is a problem in the diagnostic process. For clinical purposes, it is desirable to find subtypes of VaD that are homogeneous enough to allow meaningful comparisons across studies. This article presents candidates for such subtypes: poststroke dementia, subcortical VaD, and combined Alzheimer's disease and VaD (AD + VaD). The first two candidates are easy to identify. Poststroke dementia occurs with cognitive decline in close temporal relation to a transient ischemic attack. Subcortical VaD has a relatively homogeneous clinical picture for which detailed criteria are suggested. AD + VaD is more difficult to identify but is possible, sometimes with the aid of neuroimaging and/or biological markers.
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Di Carlo, Pasquale, Giulio Pergola, Linda A. Antonucci, Aurora Bonvino, Marina Mancini, Tiziana Quarto, Antonio Rampino, Teresa Popolizio, Alessandro Bertolino, and Giuseppe Blasi. "Multivariate patterns of gray matter volume in thalamic nuclei are associated with positive schizotypy in healthy individuals." Psychological Medicine 50, no. 9 (July 30, 2019): 1501–9. http://dx.doi.org/10.1017/s0033291719001430.
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AbstractBackgroundPrevious models suggest biological and behavioral continua among healthy individuals (HC), at-risk condition, and full-blown schizophrenia (SCZ). Part of these continua may be captured by schizotypy, which shares subclinical traits and biological phenotypes with SCZ, including thalamic structural abnormalities. In this regard, previous findings have suggested that multivariate volumetric patterns of individual thalamic nuclei discriminate HC from SCZ. These results were obtained using machine learning, which allows case–control classification at the single-subject level. However, machine learning accuracy is usually unsatisfactory possibly due to phenotype heterogeneity. Indeed, a source of misclassification may be related to thalamic structural characteristics of those HC with high schizotypy, which may resemble structural abnormalities of SCZ. We hypothesized that thalamic structural heterogeneity is related to schizotypy, such that high schizotypal burden would implicate misclassification of those HC whose thalamic patterns resemble SCZ abnormalities.MethodsFollowing a previous report, we used Random Forests to predict diagnosis in a case–control sample (SCZ = 131, HC = 255) based on thalamic nuclei gray matter volumes estimates. Then, we investigated whether the likelihood to be classified as SCZ (π-SCZ) was associated with schizotypy in 174 HC, evaluated with the Schizotypal Personality Questionnaire.ResultsPrediction accuracy was 72.5%. Misclassified HC had higher positive schizotypy scores, which were correlated with π-SCZ. Results were specific to thalamic rather than whole-brain structural features.ConclusionsThese findings strengthen the relevance of thalamic structural abnormalities to SCZ and suggest that multivariate thalamic patterns are correlates of the continuum between schizotypy in HC and the full-blown disease.
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Holst, Søren, Dorte Lystrup, and John L. Taylor. "Firesetters with intellectual disabilities in Denmark." Journal of Intellectual Disabilities and Offending Behaviour 10, no. 4 (November 28, 2019): 72–81. http://dx.doi.org/10.1108/jidob-10-2019-0021.
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Purpose The purpose of this paper is to gather epidemiologicalinformation concerning firesetters with intellectual disabilities (ID) in Denmark to identify the assessment and treatment needs of this population and inform further research in this area. Design/methodology/approach The records held by the Danish Ministry of Justice concerning all firesetters with ID convicted of deliberate firesetting were reviewed for the period January 2001 to December 2010 inclusive. File information was extracted for 83 offenders concerning: demographic and personal characteristics; mental health characteristics; offending behaviour; offence-specific factors; and motives for offending. A sub-group of seven offenders were interviewed to explore some of the themes that emerged from the file review. Findings The majority of study participants were male and were classified as having mild ID and around 50 per cent had additional mental health problems. Many came from disturbed and deprived backgrounds. Two-thirds had set more than one fire and over 60 per cent had convictions for offences other than firesetting. Alcohol was involved in the firesetting behaviour in a significant proportion of cases (25 per cent). The motives for setting fires were – in descending order – communication (of anger, frustration and distress), fire fascination and vandalism. Interviews with participants indicated the important communicative function of firesetting, the difficulties people had in talking about and acknowledging their firesetting behaviour, and lack of access to targeted interventions. Research limitations/implications Interventions for Danish firesetters with ID, as for firesetters with ID elsewhere, need to target the communicative function of this behaviour, along with offenders’ lack of insight and initial reluctance to accept responsibility for their behaviour and associated risks. Adjunctive treatment is required to address the psychiatric comorbidity experienced by many of these offenders, along with the alcohol use/misuse that is associated with many of these offences. Originality/value This is the first study concerning nature and needs of firesetters with ID in Denmark.
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Ross, Don. "Internal Recurrence." Dialogue 37, no. 1 (1998): 155–62. http://dx.doi.org/10.1017/s0012217300047648.
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Paul Churchland does not open his latest book,The Engine of Reason, the Seat of the Soul, modestly. He begins by announcing, “This book is about you. And me … More broadly still, it is about every creature that ever swam, or walked, or flew over the face of the Earth” (p. 3). A few sentences later, he says, “Fortunately, recent research into neural networks … has produced the beginnings of a real understanding of how the biological brain works—a real understanding, that is, of howyouwork, and everyone else like you” (p. 3). The implicit identification here of “me and you and everyone” with “the biological brain” might lead an uncharitable reader to view Churchland's book as “Eliminativism for the non-specialist,” that is, as an attempt to popularize the view of the mindbody problem with which, among his professional peers, Churchland has long been identified. However, I think that such a readingwouldbe uncharitable. He is, of course, frequently sceptical about the utility of folk psychology, but in this book he is much less concerned to disparage folk psychology as a failedtheory(by contrast with, for example, the arguments in Churchland 1979) than to urge the more modest view that the more we understand the brain, the better we shall be at helping those whose brains are damaged in ways that interfere seriously with the fulfilment of their lives. Hence, I am inclined to take him at his word when he says in the Preface that “The book is motivated first of all by sheer excitement over the new picture that is now emerging … [and] … also by the idea that this is information that the public needs to know” (p. xi). What excites Churchland so, at least overtly, is not the negative thesis he has defended elsewhere that folk-psychological terms fail to refer; his enthusiasm is mainly reserved for the positive thesis that minds are, essentially, interacting assemblies of recurrent neural networks. It is therefore this positive thesis, and Churchland's defence of it, that I will assess in the following discussion.
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Mościcki, Eve K. "Epidemiology of Suicide." International Psychogeriatrics 7, no. 2 (June 1995): 137–48. http://dx.doi.org/10.1017/s1041610295001931.
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This article presents the epidemiology of suicide with a special focus on suicides among the elderly, and discusses the known risk factors for suicide within a framework designed to encourage a systematic approach to theory testing and prevention. Throughout the world, suicide rates are highest among the elderly. The risk factors for suicide can be classified as distal or proximal, and, within these broad categories, as sociodemographic, psychiatric, biological, familial, and situational. Mental and addictive disorders are the major risk factors for suicide in all age groups. Other risk factors include male gender, disrupted marital status, prior suicide attempt, reduced brain stem serotonergic activity, family history of psychiatric disorder or suicide, a firearm in the home, and a recent, severely stressful life event. Since risk factors for suicide rarely occur in isolation, prevention efforts are more likely to succeed if multiple risk factors are targeted.
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Farrington, David P. "Motivations for conduct disorder and delinquency." Development and Psychopathology 5, no. 1-2 (1993): 225–41. http://dx.doi.org/10.1017/s0954579400004363.
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AbstractMotivational ideas in psychology and their relation to causes are reviewed. Key ideas include hedonism, arousal, rational decision-making, reinforcement, and impulsivity. Motivations proposed for different acts classified as conduct disorder or delinquency are discussed as well as motivational constructs in delinquency theories. It is concluded that theories should include energizing, directing, inhibiting, and decision-making stages at a minimum. Empirical studies of motivations for delinquency that involve asking youth to give reasons for their acts are also reviewed. The most common motivations reported are utilitarian (seeking money or material goods) and hedonistic (seeking excitement or pleasure). It is pointed out that the validity of motivational theories is a separate issue from the validity of verbal reports of motivations. People may be aware of immediate situational motivations but unaware of longer term biological, psychological, or social factors. A program of research on the energizing, directing, and inhibiting of antisocial behavior is recommended and on the relative effectiveness, in reducing conduct disorder and delinquency, of programs targeting these different stages.
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Laakso, Maria. "Nuorten lokerointi ja kehittyminen Salla Simukan nuortendystopiaromaaneissa Jäljellä ja Toisaalla." Sananjalka 60, no. 60. (December 17, 2018): 204–16. http://dx.doi.org/10.30673/sja.70037.
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Coming of age and classification of adolescents In Salla Simukka’s YA-dystopias Jäljellä and Toisaalla
Finnish YA-author Salla Simukka takes a current societal problem into the center of her novel pair Jäljellä (Left Over, not translated, 2012) and Toisaalla (Elsewhere, not translated, 2012). These novels criticize the current system, where even young children are forced to choose specialized studies and make decisions that affect their whole future. This is a consequence on a modern western information society, where branches of knowledge are differentiated. These theme Simukka’s novels handle with the methods off dystopic fiction.
Both novels depict a dystopic world, where adolescents are classified into groups based on their personality and their talents. Both novels depict a world very much like our own, but the time of the story lies in the near future. As usual to the dystopic fiction the author pics up some existing progressions from the reality and then extends those conditions into a future, and this way the flaws of the current conditions are revealed. In my article I claim, that Simukka’s novels take under critical consideration the whole Western concept of coming of age. Especially crucial is the idea of growth as being something controllable. In western cultures the growing up of an individual is standardized and regulated by institutions and fields of science such us daycare, school, medicine, and psychology. In Simukka’s novels this idea is exaggerated but still recognizable.
The motif of classifications or sorting the adolescents has lately been popular in YA-fantasy and YA-dystopia. Simukka’s novels borrow from two bestsellers: J.K. Rowling’s Harry Potter -series (1997–2007), and Veronica Roth’s Divergent-series (2011–2013). These examples seem to prove, that the idea of adolescents of being sorted or being classified is important in contemporary genre fiction targeting young audiences. Sorting or classification as motifs seem to be connected to the contemporary understanding of youth and growing up.
In this article I consider the classification motif in Simukka’s novel. I consentrate especially to the connections between the motif and the wider theme of growing up. I examine the motif beside the Western ideas of growth and coming of age. Besides that I also study the different genre frames Simukka’s novels use to discuss of growing up in contemporary society. These genre traditions include dystopic fiction, YA-literature and fairytale. In this article I propose, that the classification motif allegorizes the demands set to adolescents in contemporary society but also appeals to the young readers as a fantasy of belonging to the group.
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B, Bhagwat Ashlesha, and Khedkar K. M. "Impurity Profiling: A Review." Asian Journal of Pharmaceutical Research and Development 10, no. 2 (May 8, 2022): 135–43. http://dx.doi.org/10.22270/ajprd.v10i2.1052.
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Impurities are any substances, such as starting materials or intermediates, that coexist with the parent drug or arise from side reactions. Interest in impurities present in APIs continues to grow. Nowadays, not only purity profile but also impurity profile is mandated by various regulatory agencies. Impurity profiling is a generic name for a group of analytical working groups such as describing, quantifying and characterizing identified and unidentified impurities present in a new drug substance. Impurity profiling is a novel approach aimed at detecting, identifying, structuring and quantifying organic and inorganic impurities and residual solvents in pharmaceuticals. Various regulatory bodies, such as ICH, USFDA, UKMHRA, and India's CDSCO, focus on impurity profiling and have formulated guidelines for impurity management and restriction. Impurities are classified into different categories based on their origin, type of composition, and biological safety. The presence of these unwanted chemicals or substances may affect the safety and effectiveness of the final medicinal product. This review focuses on the sources of impurities, their classification, and various analytical methods for the identification and quantification of impurities. Terms such as residual solvent, by-product, transformation product, decomposition product, reaction product, and related products are often used to define impurities.
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Itoigawa, N., T. Minami, K. Kondo-Ikemura, H. Tachibana, T. Kanazawa, S. Shimizu, J. Kamada, and H. Tanabe. "Parenting and Family Support in Japan for 6- to 8-year-old Children Weighing under 1000 Grams at Birth." International Journal of Behavioral Development 19, no. 3 (September 1996): 477–90. http://dx.doi.org/10.1177/016502549601900302.
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The purpose of this study was to explore the variables related to paternal involvement in the caregiving of 6- to 8-year-old extremely low-birthweight (ELBW) children, specifically, sociodemographic factors related to the family or individual biological factors related to ELBW. Thirty-three children with a mean birthweight of 845.5 grams and a mean gestational age of 27.4 weeks participated in this research. Approximately 29% of their fathers were classified by the mothers as nonco-operative in overall child care. The paternal involvement in caregiving was related to the sociodemographic variables of the family; the co-operative fathers were proportionally more often from families where the child had no older female sibling(s) and/or grandparent(s), whereas the nonco-operative fathers were proportionally more often from families where the child had older female sibling(s) and/or grandparent(s). The individual perinatal risk variables and IQ, and the paternal variables (age, socioeconomic status) were not related to the paternal co-operativeness. Our sample mothers seemed to have raised their children in more difficult parenting and economic situations, and to have received proportionally more support from grandparent(s) than did typical Japanese mothers. The children's relationships with peers differed between the paternal co-operative and nonco-operative groups; there were proportionally more children from the nonco-operative group who preferred to play alone than to play with peer(s) at the ages of 3-5 years. Thus, scarce paternal involvement in the process of caregiving appeared to influence the children's sociability.
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Brice, Kylie L., Pankaj Trivedi, Thomas C. Jeffries, Michaela D. J. Blyton, Christopher Mitchell, Brajesh K. Singh, and Ben D. Moore. "The Koala (Phascolarctos cinereus) faecal microbiome differs with diet in a wild population." PeerJ 7 (April 1, 2019): e6534. http://dx.doi.org/10.7717/peerj.6534.
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BackgroundThe diet of the koala (Phascolarctos cinereus) is comprised almost exclusively of foliage from the genusEucalyptus(family Myrtaceae).Eucalyptusproduces a wide variety of potentially toxic plant secondary metabolites which have evolved as chemical defences against herbivory. The koala is classified as an obligate dietary specialist, and although dietary specialisation is rare in mammalian herbivores, it has been found elsewhere to promote a highly-conserved but low-diversity gut microbiome. The gut microbes of dietary specialists have been found sometimes to enhance tolerance of dietary PSMs, facilitating competition-free access to food. Although the koala and its gut microbes have evolved together to utilise a low nutrient, potentially toxic diet, their gut microbiome has not previously been assessed in conjunction with diet quality. Thus, linking the two may provide new insights in to the ability of the koala to extract nutrients and detoxify their potentially toxic diet.MethodThe 16S rRNA gene was used to characterise the composition and diversity of faecal bacterial communities from a wild koala population (n = 32) comprising individuals that predominately eat either one of two different food species, one the strongly preferred and relatively nutritious speciesEucalyptus viminalis, the other comprising the less preferred and less digestible speciesEucalyptus obliqua.ResultsAlpha diversity indices indicated consistently and significantly lower diversity and richness in koalas eatingE. viminalis. Assessment of beta diversity using both weighted and unweighted UniFrac matrices indicated that diet was a strong driver of both microbial community structure, and of microbial presence/absence across the combined koala population and when assessed independently. Further, principal coordinates analysis based on both the weighted and unweighted UniFrac matrices for the combined and separated populations, also revealed a separation linked to diet. During our analysis of the OTU tables we also detected a strong association between microbial community composition and host diet. We found that the phyla Bacteroidetes and Firmicutes were co-dominant in all faecal microbiomes, with Cyanobacteria also co-dominant in some individuals; however, theE. viminalisdiet produced communities dominated by the generaParabacteroidesand/orBacteroides, whereas theE. obliqua-associated diets were dominated by unidentified genera from the family Ruminococcaceae.DiscussionWe show that diet differences, even those caused by differential consumption of the foliage of two species from the same plant genus, can profoundly affect the gut microbiome of a specialist folivorous mammal, even amongst individuals in the same population. We identify key microbiota associated with each diet type and predict functions within the microbial community based on 80 previously identifiedParabacteroidesand Ruminococcaceae genomes.
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Nigg, Joel, Molly Nikolas, Karen Friderici, Leeyoung Park, and Robert A. Zucker. "Genotype and neuropsychological response inhibition as resilience promoters for attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder under conditions of psychosocial adversity." Development and Psychopathology 19, no. 3 (June 2007): 767–86. http://dx.doi.org/10.1017/s0954579407000387.
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Whereas child personality, IQ, and family factors have been identified as enabling a resilient response to psychosocial adversity, more direct biological resilience factors have been less well delineated. This is particularly so for child attention-deficit/hyperactivity disorder (ADHD), which has received less attention from a resilience perspective than have associated externalizing disorders. Children from two independent samples were classified as resilient if they avoided developing ADHD, oppositional defiant disorder (ODD), or conduct disorder (CD) in the face of family adversity. Two protective factors were examined for their potential relevance to prefrontal brain development: neuropsychological response inhibition, as assessed by the Stop task, and a composite catecholamine genotype risk score. Resilient children were characterized in both samples by more effective response inhibition, although the effect in the second sample was very small. Genotype was measured in Sample 1, and a composite high risk genotype index was developed by summing presence of risk across markers on three genes expressed in prefrontal cortex: dopamine transporter, dopamine D4 receptor, and noradrenergic alpha-2 receptor. Genotype was a reliable resilience indicator against development of ADHD and CD, but not ODD, in the face of psychosocial adversity. Results illustrate potential neurobiological protective factors related to development of prefrontal cortex that may enable children to avoid developing ADHD and CD in the presence of psychosocial adversity.
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Pizzonia, Kendra L., Andrew M. Bryant, Leatha A. Clark, Brian C. Clark, and Julie A. Suhr. "A-11 Investigating Gene–Gene Interactions by Cognitive Domain in Healthy Older Adults." Archives of Clinical Neuropsychology 36, no. 6 (August 30, 2021): 1051. http://dx.doi.org/10.1093/arclin/acab062.29.
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Abstract Objective ApoE is a well-known gene carrying risk for Alzheimer’s disease and is associated with memory performance while the COMT gene is associated with executive functioning but is understudied. The present study investigated these gene interactions across cognitive domains. Method A larger study on gait and aging recruited 89 healthy community-dwelling adults over the age of 60. The primary analyses included 82 participants (67% female, mean age = 74.61, SD = 6.71). The analyses on executive functioning included 72 participants (65% female, mean age = 73.02, SD = 4.99) who completed all measures of interest. ApoE status was defined as presence/absence of Ɛ4. The rs4680 gene on the COMT allele was classified into Val/Met, Val/Val, and Met/Met genotypes. Biological sex was included as a binary term (i.e., male/female). Index variables and age corrected standard scores on the Repeatable Battery for the Assessment of Neuropsychological Status, verbal fluency, and Trail Making Test were included. Results Gene–gene interactions were found for overall cognitive functioning, immediate memory, and semantic fluency. There were main effects of sex for overall cognitive functioning, immediate memory, delayed memory, and semantic fluency. There were main effects for COMT for delayed memory and a main effect for both COMT and ApoE for visuospatial functioning, coding, and verbal fluency (all p’s < 0.05). There were no ApoE x COMT x Sex interactions and Trail Making Test B was not related to either gene or sex. Conclusion(s) Our findings suggest that both COMT and ApoE (and their interaction) influence cognition. Future research should investigate gene–gene interactions in larger samples with more comprehensive cognitive batteries.
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Thakare, VJ, AA Pande, VB Mahajan, AG Gedam, MM Todkar, and MB Satghare. "MULTIDISCIPLINARY FORENSIC ANALYSIS ACTS AS AN EYEWITNESS TO LINK THE CRIME- CULPRIT- CRIME SCENE- DECEASED. - AN INTERESTING CASE STUDY." International Journal of Engineering Applied Sciences and Technology 7, no. 4 (August 1, 2022): 99–108. http://dx.doi.org/10.33564/ijeast.2022.v07i04.014.
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: Different types of evidence found on the crime scene can be classified into biological, chemical, physical, and digital. Biological evidence is a person's body fluids, hair, tissue, etc, chemical evidence is any material used in the crime such as poison, drugs, inflammable substances, chili powder, etc, objects such as weapons, soil, fibers, broken glass piece, etc constitute physical evidence and digital evidence includes CCTV footage, online purchase history of weapons, mobile phones, pen drive, etc. These evidences are analyzed by different disciplines of forensic science like Biology, DNA, Chemistry, Toxicology, Ballistics, and Cyber. In a gruesome murder that took place in broad daylight, the victim's car was surrounded by a few people at a traffic signal. Car's window glasses were broken and he was brutally murdered using sharp-edged weapons. Forensic Science Laboratory helped the investigating agency to collect evidences at the crime scene. Almost every discipline of forensic science was involved in the analysis of the evidences found (biological, chemical, physical and digital). Detection, assessment and interpretation of the evidences aided to fix the crime scene, the presence of the accused on the crime scene and his involvement in the crime. This multidisciplinary analysis freed the investigating agency from dependency on eyewitnesses. Thus, scientific evidence from various disciplines of forensic science contributed their part and completed the whole picture of murder.
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Kotyuk, Eszter, Anna Magi, Andrea Eisinger, Orsolya Király, Andrea Vereczkei, Csaba Barta, Mark D. Griffiths, et al. "Co-occurrences of substance use and other potentially addictive behaviors: Epidemiological results from the Psychological and Genetic Factors of the Addictive Behaviors (PGA) Study." Journal of Behavioral Addictions 9, no. 2 (June 2020): 272–88. http://dx.doi.org/10.1556/2006.2020.00033.
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AbstractBackground and aimsChanges in the nomenclature of addictions suggest a significant shift in the conceptualization of addictions, where non-substance related behaviors can also be classified as addictions. A large amount of data provides empirical evidence that there are overlaps of different types of addictive behaviors in etiology, phenomenology, and in the underlying psychological and biological mechanisms. Our aim was to investigate the co-occurrences of a wide range of substance use and behavioral addictions.MethodsThe present epidemiological analysis was carried out as part of the Psychological and Genetic Factors of the Addictive Behaviors (PGA) Study, where data were collected from 3,003 adolescents and young adults (42.6% males; mean age 21 years). Addictions to psychoactive substances and behaviors were rigorously assessed.ResultsData is provided on lifetime occurrences of the assessed substance uses, their co-occurrences, the prevalence estimates of specific behavioral addictions, and co-occurrences of different substance use and potentially addictive behaviors. Associations were found between (i) smoking and problematic Internet use, exercising, eating disorders, and gambling (ii) alcohol consumption and problematic Internet use, problematic online gaming, gambling, and eating disorders, and (iii) cannabis use and problematic online gaming and gambling.ConclusionsThe results suggest a large overlap between the occurrence of these addictions and behaviors and underlies the importance of investigating the possible common psychological, genetic and neural pathways. These data further support concepts such as the Reward Deficiency Syndrome and the component model of addictions that propose a common phenomenological and etiological background of different addictive and related behaviors.
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Krishna, Peddarapu Rama, and Pothuraju Rajarajeswari. "EapGAFS: Microarray Dataset for Ensemble Classification for Diseases Prediction." International Journal on Recent and Innovation Trends in Computing and Communication 10, no. 8 (August 31, 2022): 01–15. http://dx.doi.org/10.17762/ijritcc.v10i8.5664.
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Microarray data stores the measured expression levels of thousands of genes simultaneously which helps the researchers to get insight into the biological and prognostic information. Cancer is a deadly disease that develops over time and involves the uncontrolled division of body cells. In cancer, many genes are responsible for cell growth and division. But different kinds of cancer are caused by a different set of genes. So to be able to better understand, diagnose and treat cancer, it is essential to know which of the genes in the cancer cells are working abnormally. The advances in data mining, machine learning, soft computing, and pattern recognition have addressed the challenges posed by the researchers to develop computationally effective models to identify the new class of disease and develop diagnostic or therapeutic targets. This paper proposed an Ensemble Aprior Gentic Algorithm Feature Selection (EapGAFS) for microarray dataset classification. The proposed algorithm comprises of the genetic algorithm implemented with aprior learning for the microarray attributes classification. The proposed EapGAFS uses the rule set mining in the genetic algorithm for the microarray dataset processing. Through framed rule set the proposed model extract the attribute features in the dataset. Finally, with the ensemble classifier model the microarray dataset were classified for the processing. The performance of the proposed EapGAFS is conventional classifiers for the collected microarray dataset of the breast cancer, Hepatities, diabeties, and bupa. The comparative analysis of the proposed EapGAFS with the conventional classifier expressed that the proposed EapGAFS exhibits improved performance in the microarray dataset classification. The performance of the proposed EapGAFS is improved ~4 – 6% than the conventional classifiers such as Adaboost and ensemble.
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Álvarez-Sánchez, Lourdes, Carmen Peña-Bautista, Miguel Baquero, and Consuelo Cháfer-Pericás. "Novel Ultrasensitive Detection Technologies for the Identification of Early and Minimally Invasive Alzheimer’s Disease Blood Biomarkers." Journal of Alzheimer's Disease 86, no. 3 (April 5, 2022): 1337–69. http://dx.doi.org/10.3233/jad-215093.
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Background: Single molecule array (SIMOA) and other ultrasensitive detection technologies have allowed the determination of blood-based biomarkers of Alzheimer’s disease (AD) for diagnosis and monitoring, thereby opening up a promising field of research. Objective: To review the published bibliography on plasma biomarkers in AD using new ultrasensitive techniques. Methods: A systematic review of the PubMed database was carried out to identify reports on the use of blood-based ultrasensitive technology to identify biomarkers for AD. Results: Based on this search, 86 works were included and classified according to the biomarker determined. First, plasma amyloid-β showed satisfactory accuracy as an AD biomarker in patients with a high risk of developing dementia. Second, plasma t-Tau displayed good sensitivity in detecting different neurodegenerative diseases. Third, plasma p-Tau was highly specific for AD. Fourth, plasma NfL was highly sensitive for distinguishing between patients with neurodegenerative diseases and healthy controls. In general, the simultaneous determination of several biomarkers facilitated greater accuracy in diagnosing AD (Aβ42/Aβ40, p-Tau181/217). Conclusion: The recent development of ultrasensitive technology allows the determination of blood-based biomarkers with high sensitivity, thus facilitating the early detection of AD through the analysis of easily obtained biological samples. In short, as a result of this knowledge, pre-symptomatic and early AD diagnosis may be possible, and the recruitment process for future clinical trials could be more precise. However, further studies are necessary to standardize levels of blood-based biomarkers in the general population and thus achieve reproducible results among different laboratories.
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Abdul Rahman, Mohd Zahir, Robiatul Adawiyah Mohd@Amat, Zul Azlin Razali, Mohd Zohdi Mohd Amin, Shah Rizul Izyan Zulkiply, and Ahmad Murshidi Mustapa. "Pendekatan Terapi Waswas Menurut Perspektif Sarjana Islam Di Era Ketamadunan Islam Abad Ke 8 Sehingga 19 Masihi." Sains Insani 3, no. 3 (December 6, 2018): 15–20. http://dx.doi.org/10.33102/sainsinsani.vol3no3.67.
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Waswas atau kecelaruan obsesif-kompulsif (OCD) merupakan antara sepuluh beban penyakit utama di seluruh dunia yang diklasifikasikan oleh World Health Organization (WHO) (Murray, 1996). Sehubungan itu, kupasan terhadap isu waswas ini dari aspek rawatan dan penyelidikan banyak dirujuk kepada psikiatri moden dan klinikal psikologi. Walaubagaimanapun pendekatan rawatan waswas menurut sarjana Islam di era ketamadunan Islam kurang diketengahkan kepada masyarakat. Justeru, objektif kajian adalah untuk mengumpul dan mengenal pasti fokus rawatan waswas oleh sarjana Islam pada abad ke 8 sehingga abad 19 Masihi di bawah pemerintahan khilafah Islam berteraskan empat domain hidup iaitu biologi, psikologi, sosial dan spiritual. Manakala dari aspek metode, kajian mengaplikasi sepenuhnya kajian kualitatif berasaskan dokumentasi. Hasil kajian mendapati bahawa terdapat sebanyak 10 terapi berasaskan biologi, 6 pendekatan psikologi, 3 pendekatan bersifat sosial dan 2 amalan beserta 8 doa sebagai pendekatan rawatan secara spiritual. Penemuan ini amat berharga kepada masyarakat Islam kerana keperluan dalam keseimbangan empat elemen ini penting bagi mengatasi masalah waswas dan tidak hanya tertumpu kepada pendekatan rawatan bersifat spiritual.Abstract: Waswas or obsessive-compulsive disorder (OCD) is one of ten major illnesses worldwide are classified by the World Health Organization (WHO) (Murray, 1996). In this regard, the focus on this issue of treatment and research has been widely referred to modern psychiatry and clinical psychology. However, waswas treatment based on Islamic scholars in Islamic civilisation era less highlighted to the community. Thus, the objective of the study is to collect and identify the focus of waswas treatment by Islamic scholars in 8 century until 19 century under the reign of Caliph of Islam is based on four domains of life that is biological, psychological, social and spiritual. While, the methodological approach taken in this study is a qualitative research through documentation. The findings show that there are 10 biological-based therapies, 6 psychological approaches, 3 social approaches and 2 practices and 8 dua’ as a spiritual approach. These findings are very very valuable to the Muslim community because the needs in this important balance four elements to overcome waswas and not just focused on spiritual approaches.
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Levy, Boaz, Amanda Priest, Tyler Delaney, Jacqueline Hogan, and Farahdeba Herrawi. "Toward Pre-Diagnostic Detection of Dementia in Primary Care." Journal of Alzheimer's Disease 86, no. 1 (March 8, 2022): 479–90. http://dx.doi.org/10.3233/jad-215242.
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Background: Preventing dementia warrants the pragmatic engagement of primary care. Objective: This study predicted conversion to dementia 12 months before diagnosis with indicators that primary care can utilize within the practical constraints of routine practice. Methods: The study analyzed data from the Alzheimer’s Disease Neuroimaging Initiative (Total sample = 645, converting participants = 54). It predicted the conversion from biological (plasma neurofilament light chain), cognitive (Trails Making Test– B), and functional (Functional Activities Questionnaire) measures, in addition to demographic variables (age and education). Results: A Gradient Booster Trees classifier effectively predicted the conversion, based on a Synthetic Minority Oversampling Technique (n = 1,290, F1 Score = 92, AUC = 94, Recall = 87, Precision = 97, Accuracy = 92). Subsequent analysis indicated that the MCI False Positive group (i.e., non-converting participants with cognitive impairment flagged by the model for prospective conversion) scored significantly lower on multiple cognitive tests (Montreal Cognitive Assessment, p < 0.002; ADAS-13, p < 0.0004; Rey Auditory Verbal Learning Test, p < 0.002/0.003) than the MCI True Negative group (i.e., correctly classified non-converting participants with cognitive impairment). These groups also differed in CSF tau levels (p < 0.04), while consistent effect size differences emerged in the all-pairwise comparisons of hippocampal volume and CSF Aβ1 - 42. Conclusion: The model effectively predicted 12-month conversion to dementia and further identified non-converting participants with MCI, in the False Positive group, at relatively higher neurocognitive risk. Future studies may seek to extend these results to earlier prodromal phases. Detection of dementia before diagnosis may be feasible and practical in primary care settings, pending replication of these findings in diverse clinical samples.
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Rosenthal, Richard. "The categorization of pathological gambling and the Impulse-Control Disorders Not Elsewhere Classified." Journal of Gambling Issues, no. 15 (December 1, 2005). http://dx.doi.org/10.4309/jgi.2005.15.15.
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"Joy, Not Elsewhere Classified—Towards a Contemporary Psychological Understanding of Spiritual (and Secular) Awakening." International Journal of Transpersonal Studies 37, no. 2 (September 1, 2018). http://dx.doi.org/10.24972/ijts.2018.37.2.66.
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Harris, Charlie L., Brian M. Goldman, Pinar Gurkas, Crystal Butler, and Priscilla Bookman. "Superwoman’s kryptonite: The superwoman schema and perceived barriers to weight management among U.S. Black women." Journal of Health Psychology, January 28, 2022, 135910532110689. http://dx.doi.org/10.1177/13591053211068974.
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The role that the superwoman schema (SWS) plays in U.S. Black women’s perceptions of barriers (biological, psychological, and sociological) to healthy weight management is unknown. This exploratory study examined whether 122 women classified as normal weight, overweight or obese differed in their perceptions of types of barriers and if the SWS predicted perceived barriers to weight management. Women classified as obese reported more barriers than those classified as normal weight. The SWS uniquely positively predicted perceived psychological and sociological barriers. Our findings suggest that the SWS may play a vital role in the self-management of weight in U.S. Black women.
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Harris, Paul L. "Young children’s representation of people who are elsewhere—Or dead." International Journal of Behavioral Development, December 22, 2022, 016502542211442. http://dx.doi.org/10.1177/01650254221144268.
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Given the legacy of John Bowlby, Attachment theory has often portrayed separation from a caregiver as likely to provoke protest, despair, and ultimately detachment in infants and young children. Indeed, the emotional challenge of separation is built into a key measurement tool of Attachment theory, the Strange Situation. However, James Robertson, one of Bowlby’s leading collaborators, voiced dissent. He argued that young children can cope with separations—even when they last for several days or weeks. They are able to keep the absent person in mind provided an alternative, familiar caregiver remains available. Observational and experimental findings lend support to Robertson’s claim. Recent analyses of natural language provide further support. Although young toddlers (ranging from 20 to 26 months) often make contact- or attachment-related comments about absent caregivers, such comments become less frequent with age whereas reflective references to absent caregivers—comments that do not express contact-related concerns about their absence—are often produced by young toddlers and remain frequent throughout early childhood. Children’s early-emerging ability to keep an absent attachment figure in mind raises intriguing questions about their responses to the permanent absence of an attachment figure—as in the case of death. Consistent with contemporary research showing that many grieving adults report continuing bonds to a deceased attachment figure—rather than a gradual process of emotional detachment—children also report such continuing bonds. By implication, children and adults are prone to construe the death of a loved one not just as a biological endpoint that terminates the possibility of any continuing relationship but instead as a departure that can be bridged by a continuation of the earlier bond in an altered form.
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Ramašauskas, Olegas, Ilona Rupšienė, and Mantas Kazlauskas. "Digital filters creation of seabed image processing." Lietuvos matematikos rinkinys 56 (December 20, 2015). http://dx.doi.org/10.15388/lmr.b.2015.21.
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Nowadays visual information is extracted using a variety of physical methods and cannot always be easily perceived by the human eye, properly recognized and classified. Such large amounts of information provided by the modern image-making equipment is difficult and sometimes impossible objectively evaluate. Research of digital images carried out at the Klaipėda University with a focus on marine research topic. The combination of new underwater technology as remotely operating vehicles, high-resolution video imagery, and seafloor mosaics creating provides new opportunities for marine geological or biological studies. While these underwater techniques are now well-engineered, there is still a lack of methods for the automatic analysis of the acquired image data. In this paper, the video mosaic quality and processing problems discussed. Believes that the versatility of abstract techniques to tailor the fields of biomedical sciences, applied robotics and elsewhere. This could be listed as a main purpose of presented work.