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1

Levchyck, N. Ya. "BIOLOGICAL ACTIVITY OF SUCCINIC ACIDS." Biotechnologia Acta 10, no. 6 (December 2017): 53–60. http://dx.doi.org/10.15407/biotech10.06.053.

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Tsyganenko, K. S., Ya I. Savchuk, L. T. Nakonechna, and I. M. Kurchenko. "The Biological Activity of Alternaria Species." Mikrobiolohichnyi Zhurnal 80, no. 4 (July 30, 2018): 78–87. http://dx.doi.org/10.15407/microbiolj80.04.078.

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3

Varbanets, L. D. "SEROLOGICAL AND BIOLOGICAL ACTIVITY OF LIPOPOLYSACCHARIDE." Biotechnologia Acta 8, no. 1 (March 23, 2015): 32–38. http://dx.doi.org/10.15407/biotech8.01.032.

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4

Varbanets, L. D. "SEROLOGICAL AND BIOLOGICAL ACTIVITY OF LIPOPOLYSACCHARIDE." Biotechnologia Acta 8, no. 1 (March 23, 2015): 56–62. http://dx.doi.org/10.15407/biotech8.01.056.

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5

Naumenko, K., A. Golovan, and S. Zagorodnya. "Prediction of Biological Activity of Triazoles Derivatives." Mikrobiolohichnyi Zhurnal 82, no. 1 (February 17, 2020): 51–61. http://dx.doi.org/10.15407/microbiolj82.01.051.

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6

Pirog, T. P. "INFLUENCE OF BIOLOGICAL INDUCTORS ON THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF MICROBIAL METABOLITES." Biotechnologia Acta 16, no. 6 (December 12, 2023): 17–33. http://dx.doi.org/10.15407/biotech16.06.017.

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The increasing antibiotic resistance is a severe concern for humanity. Co-cultivation of microorganisms is a promising method for obtaining new secondary antimicrobial metabolites. An effective strategy for co-cultivation of microorganisms involves the usage of certain biological inductors. The aim of this review is to summarize existing scientific research in the literature related to the influence of physiologically different types of biological inductors on the synthesis and biological activity of microbial secondary metabolites. An analysis of the literature has shown that in such studies, either live or inactivated cells of the inductor are added to the culture medium at significantly lower concentrations compared to the producer cells of the final metabolites, or the supernatant (filtrate) after cultivation of a competitive microorganism is used as an inductor. According to the literature and our own experimental studies, the using inductors is an effective approach not only for intensifying the synthesis of bacteriocins, surfactants, and antibiotics, but also for increasing their biological activity. Additionally, it often leads to the production of novel antimicrobial compounds that are not typical for the producer. However, the mechanisms of effect of inductors on the synthesis of biologically active secondary metabolites require further research, as the literature suggests that their introduction into the cultivation medium of producer does not always lead to an intensification of the synthesis of the final product. Moreover, the biological activity of secondary metabolites depends on the cultivation conditions of the producer, including the presence of biological inductors in the culture medium. Therefore, it is essential to conduct further research on the interaction between producers and competitive microorganisms to regulate the biological activity of the synthesised metabolites. In addition, there is a necessity to search for more cost-effective substrates for the biosynthesis of secondary metabolites, optimize the composition of the culture medium and expand the range of both pro- and eukaryotic inductors.
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Shukurov, C. Y. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW DITHIOCARBAMATE DERIVATIVES." Chemical Problems 18, no. 2 (2020): 174–80. http://dx.doi.org/10.32737/2221-8688-2020-2-174-180.

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8

Varbanets, L. D., Т. V. Bulyhina, L. А. Pasichnyk, and N. V. Zhytkevich. "Рantoea agglomerans lipopolysaccharides: structure, functional and biological activity." Ukrainian Biochemical Journal 91, no. 1 (January 28, 2019): 5–20. http://dx.doi.org/10.15407/ubj91.01.005.

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9

Hassanein, M. M. M., F. S. Taha, S. M. Wagdy, and S. F. Hamed. "Evaluation of the biological activity of sunflower hull extracts." Grasas y Aceites 63, no. 2 (April 18, 2012): 184–92. http://dx.doi.org/10.3989/gya.072111.

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10

Varbanets, L. D. "Structure, Function and Biological Activity of Lipopolysaccharide Lipid A." Mikrobiolohichnyi Zhurnal 78, no. 6 (November 30, 2016): 37–49. http://dx.doi.org/10.15407/microbiolj78.06.037.

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11

Brovarska, O. S., L. D. Varbanets, and S. V. Kalinichenko. "Chemical Characterization and Biological Activity of Escherichia coli Lipopolysaccharides." Mikrobiolohichnyi Zhurnal 82, no. 6 (November 30, 2020): 35–42. http://dx.doi.org/10.15407/microbiolj82.06.035.

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Lipopolysaccharides (LPS) are specific components of the cell envelope of gram-negative bacteria, located at the external surface of their outer membrane and performing a number of important physicochemical and biological functions. The widespread in nature are representatives of Enterobacteriaceae family. Among them there are saprotrophic, useful human symbionts, as well as causative agents of acute intestinal infections. The role of saprophytic intestinal microbiota is not limited only to its participation in the digestion process. The endotoxin released as a result of self-renewal of the cell pool of Escherichia coli partially enters the portal blood and performs antigenic stimulation of the macroorganism. In addition, a small amount of endotoxin can also be released by live gram-negative bacteria, which, given the large population of E. coli in the intestine, can create a sufficiently high concentration of endotoxin. Aim. The study of composition and biological activity of lipopolysaccharides of new E. coli strains, found in the human body. Methods. The objects of investigation were strains of Escherichia coli, isolated from healthy patients at the epidemiological center in Kharkiv. Lipopolysaccharides were extracted from dried cells by 45% phenol water solution at 65–68°С by Westphal and Jann method. The amount of carbohydrates was determined by phenol-sulfuric method. Carbohydrate content was determined in accordance to the calibration curve, which was built using glucose as a standard. The content of nucleic acids was determined by Spirin method, protein − by Lowry method. Serological activity of LPS was investigated by double immunodiffusion in agar using the method of Ouchterlony. Results. In all studied E. coli LPS (2884, 2890, 2892), glucose was dominant monosaccharide (40.5, 41.1, 67.3%, respectively). LPS also contained rhamnose (1.8, 22.9, 1.6%, respectively), ribose (3.5, 6.1, 3.6%, respectively) and galactose (4.1, 20.2, 18.3%, respectively). E. coli 2884 LPS also contained arabinose (1.0%) and mannose (44.8%), while E. coli strains 2890 and 2892 LPS contained heptose (9.7 and 7.8%, respectively). Lipid A composition was presented by fatty acids with a carbon chain length from C12 to C18. As the predominant components were 3-hydroxytetradecanoic (39.2–51.3%) as well as tetradecanoic (23.1–28.5%), dodecanoic (8.9–10.9%), hexadecanoic (4.3–7.2%) and octadecanoic (1.8–2.4%) acids. Unsaturated fatty acids: hexadecenoic (2.0–17.9%) and octadecenoic (3.4–4.2%) have been also identified. It was found that octadecanoic and octadecenoic acids were absent in the LPS of 2884 and 2892 strains, respectively. In SDS-PAAG electrophoresis, a bimodal distribution typical for S-forms of LPS was observed. The studied LPS were toxic and pyrogenic. Double immunodiffusion in agar by Ouchterlony revealed that the tested LPS exhibited an antigenic activity in the homologous system. In heterologous system E. coli 2892 LPS had cross reactivity with LPS of E. coli 2890 and М-17. Since the structure of the O-specific polysaccharide (OPS) of E. coli M-17 was established by us earlier, the results of serological reactions make it possible to suggest an analogy of the E. coli 2892 and 2890 OPS structures with that of E. coli М-17 and their belonging to the same serogroup. Conclusions. The study of the composition and biological activity of LPS of new strains of Escherichia coli 2884, 2890 and 2892, isolated from the body of almost healthy patients, expands our knowledge about the biological characteristics of the species.
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12

Yuldasheva, N. K., S. D. Gusakova, D. X. Nurullaeva, R. P. Zakirova, E. R. Kurbanova, and N. T. Farmanova. "Biological Activity Of Oats Fruit Lipids (Avena Sativa L.)." American Journal of Agriculture and Biomedical Engineering 02, no. 09 (September 27, 2020): 67–70. http://dx.doi.org/10.37547/tajabe/volume02issue09-11.

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13

Vsevolod Horyachko, Vsevolod, Oksana Hoholyuk, Taras Ryzhyi, and Serhiy Rendzinyak. "Mathematical model of electrical activity of biological network areas." Computational Problems of Electrical Engineering 9, no. 2 (November 10, 2019): 8–12. http://dx.doi.org/10.23939/jcpee2019.02.008.

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In the paper, the mathematical model describing the generation of action potential and propagation of an impulse in the neuron's filaments on the basis of the analysis of parametric electriс circuits with distributed parameters and the mathematical model of synaptic interneuron connections are proposed. Developed models allow taking into account the influence of such factors as geometric, physical and chemical parameters of the neuron's filaments and the presence of different neurotransmitters in chemical synapses on transmitting a neural impulse. Further, such models can be used for investigating the conditions of neuron firing at spatial and time integration of input signals, as well as for the simulation of neuromuscular junctions.
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14

Gupta, Monika. "Synthesis and Biological Activity of 6-Substituted Pyrimidine-2,4- Dionesderivatives." International Journal of Pharmacognosy & Chinese Medicine 5, no. 1 (2021): 1–9. http://dx.doi.org/10.23880/ipcm-16000211.

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Cancer is a terrible disease and second leading cause of death, behind cardio-vascular disease in the world. At present, there are three main methods of cancer treatment: surgery, radiation therapy and chemotherapy. Pyrimidineis a six-membered heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3. Pyrimidine derivatives occupy a distinct and unique place in chemotherapy. The chemotherapeutic efficacy of pyrimidine derivatives is related to their ability to inhibit vital enzymes responsible for DNA biosynthesis as dihydrofolatereductase (DHFR), thymidylatesynthetase (TSase), thymidine phosphorylase (TPase) and reverse transcriptase (RTase). In the present study involves synthesis of 6-Substituted pyrimidine 2,4-diones derivatives. The synthesized compounds were subjected to antimicrobial activity against Gram negative E. coli (MTCC 40) and S. aureus (MTCC 87). The synthesized compounds possessed good to moderate antibacterial activity. Compounds 1, 2, 3a possessed good antibacterial activity when compared with standard however the compounds 2a, 2b, 2d, 1b, 1d, 1e possessed moderate activity. 1c, 1d, 1a, 2e, 2c were observed to be totally inactive compounds. The derivatives with electron withdrawing substituent on the phenyl ring at para position had poor activity in comparison to derivatives possessing no or electron donating substituents. The structures of the synthesized compounds were established by IR and NMR spectral studies.
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15

Remeš, J., and R. Šíša. "Biological activity of anthropogenic soils after spoil-bank forest reclamation." Journal of Forest Science 53, No. 7 (January 7, 2008): 299–307. http://dx.doi.org/10.17221/2075-jfs.

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The paper presents the results of relatively long-term research focused on spoil bank revitalization pro-cesses in the North Bohemian Brown Coal Basin after the first three years of observations. The biological activity of soil (namely catalase and phosphatase activity), indicators of basal and potential soil respiration, ammonification and growth, development and nutrition status of forest plantations were selected as indicators of this revitalization process. These parameters were determined in five localities of different age of reclamation where different technological approaches and tree species compositions were used. The results confirm the distinct time dependence of revitalization processes. From the aspect of biological activity older reclamations are close to natural forest soil. The enrichment of top soil layer with organic matter before the plantation (by ploughing in cellulose fibres and peat addition) increased some parameters of soil biological activity. The positive amelioration effect of black alder (<i>Alnus glutinosa</i>) was also confirmed.
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16

Bohdan, Anna, Yanina Romanenko, Mikhail Zavhorodnii, Maryna Kornet, Vasyl Shupeniuk, Amaladoss Nepolraj, Olena Klimova, and Oleksandr Brazhko. "Design, Synthesis and Biological Activity of the 4-Thioquinoline Derivative." Chemistry & Chemical Technology 17, no. 4 (December 25, 2023): 774–85. http://dx.doi.org/10.23939/chcht17.04.774.

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One of the promising areas in the creation of bioregulators is the modeling of compounds that combine several pharmacophores. The design of new highly efficient and low-toxic cytoprotectors is largely based on the derivatives of nitrogen-containing heterocycles, and quinoline plays a significant role among these compounds. The researchers evaluated the toxicity of the tested compounds in silico, in vitro, and in vivo, which allowed determiningseveral factors that affect the level of toxic action of 4-thioquinoline derivatives and the direction of non-toxic substances in this sequence. The studied 4-thioquinolines showed a moderate antiradical action in the experiment, inferior to the reference antioxidant Acetylcysteine. The most active compounds are 7-chloro-4-thioquinoline derivatives with propanoic acid residues in the 4th position. 2-(7-chloroquinolin-4-ylthio)propanoic acid and sodium salt of 2-amino-3-((7-chloroquinolin-4-yl)thio)propanoic acid showed the most promising results and their antioxidant action was higher than Tiotriazolin (the comparator) by 27 % and 41 %, respectively. The studied compounds showed a protective effect under H2O2-induced oxidative stress against male sperm according to the main indicators of sperm fertility. It was found that the compounds withresidues of succinic acid, cysteamine, or cysteine in the molecule structure are not inferior to reference drugs. On average, 2-((7-chloroquinolin-4-yl)thio)succinic acid and 2-((quinolin-4-yl)thio)ethanaminedihydrochloride exceeded the comparison drug Acetylcysteine and were on a par with the effect of Ascorbic acid.
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17

Inamori, Yoshihiko, Chikaaki Muro, Eiko Sajima, Motoharu Katagiri, Yukiko Okamoto, Hajime Tanaka, Yoshikazu Sakagami, and Hiroshi Tsujibo. "Biological Activity of Purpurogallin." Bioscience, Biotechnology, and Biochemistry 61, no. 5 (January 1997): 890–92. http://dx.doi.org/10.1271/bbb.61.890.

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18

Morita, Yasuhiro, Eiko Matsumura, Toshihiro Okabe, Mitsunobu Shibata, Masaaki Sugiura, Tatsuhiko Ohe, Hiroshi Tsujibo, Nakao Ishida, and Yoshihiko Inamori. "Biological Activity of Tropolone." Biological & Pharmaceutical Bulletin 26, no. 10 (2003): 1487–90. http://dx.doi.org/10.1248/bpb.26.1487.

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19

El-Shazly, M., M. Saleh, L. Coulton, G. Andrew, M. Beneton, R. Hannon, and R. Eastell. "Biological activity in nonunions." Journal of Orthopaedic Trauma 13, no. 4 (May 1999): 313. http://dx.doi.org/10.1097/00005131-199905000-00083.

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20

Özsoylu, Şinasi. "Biological Activity of Calcitriol." Archives of Pediatrics & Adolescent Medicine 141, no. 10 (October 1, 1987): 1039. http://dx.doi.org/10.1001/archpedi.1987.04460100017006.

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21

Formánek, P., and V. Vránová. "The effect of spruce stand thinning on biological activity in soil." Journal of Forest Science 49, No. 11 (January 16, 2012): 523–30. http://dx.doi.org/10.17221/4795-jfs.

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The effect of thinning of young spruce stands by 500 trees/ha on biological activity in the soil profile was studied in the mountainous area of the Moravian-Silesian Beskids. The biological activity of soil was determined under optimal laboratory conditions by tests of soil respiration, catalase activity and intensity of cellulose decomposition. No statistically significant differences were found between the individual biological tests when the two experimental stands were compared (P-level 0.05). All biological activities within each stand were correlated, and significant correlations were found between biological activities in the soil and ammonium nitrogen content.
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22

Abd El Baky, H. H., F. K. El Baz, G. S. El Baroty, O. I. Abd El-Salam, and E. A. Ibrahim. "Structural characterization and Biological Activity of Sulfolipids from selected Marine Algae." Grasas y Aceites 64, no. 5 (October 23, 2013): 561–71. http://dx.doi.org/10.3989/gya.050213.

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23

Tashenov, Y. O., K. V. Van Hecke, Y. M. Suleimen, and K. Akatan. "Crystal structure and biological activity of tetra-tosyl derivative of quercetin." BULLETIN of the L.N. Gumilyov Eurasian National University. Chemistry. Geography. Ecology Series 123, no. 2 (2018): 27–32. http://dx.doi.org/10.32523/2616-6771-2019-123-2-8-27-32.

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24

Růžková, M., L. Růžek, and K. Voříšek. "Soil biological activity of mulching and cut/harvested land set aside." Plant, Soil and Environment 54, No. 5 (May 19, 2008): 204–11. http://dx.doi.org/10.17221/396-pse.

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Formerly arable luvic chernozem set aside for ten years (1997–2006) with different herbaceous cover (grass, legumes and their mixtures) and agronomical practices (mulching and cut/harvesting) was studied. The experimental plot was maintained as black, spontaneous and controlled fallows from 1997 until July 2003 (BD period). In July 2003 the plots were desiccated by glyphosate herbicide and were run as a black fallow until August 2004 (AD). The last period (AG) was characterized by monoculture of Italian ryegrass cut/harvested twice a year until October 2006. The experimental soils were characterized with 18 parameters. Mulched plots in all periods (BD, AD and AG) were evaluated as highly microbial active plots. The black fallow (BD) permanently maintained by glyphosate herbicide was the lowest in biological parameters. The desiccation caused a highly significant increase (<I>P</I> < 0.01) of nitrates in topsoil, but in following period (AG) their significant decrease was detected. Desiccation enhanced carbon immobilization into microbial cells especially on mulched and cut/harvested sites (BD, AD). Due to mulching accumulation of soil organic matter highly significantly increased (<I>P</I> < 0.01). This induced a highly significant (<I>P</I> < 0.01) increase in the basal respiration (AD, AG) as the soil organic matter accumulated in the period BD was intensively mineralized.
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25

Kurmantayeva, Gulnissa, Alexandr Borisovich Marchenko, Svetlana Aleksandrovna Ivasenko, Rosa Battalovna Seidakhmetova, Marlen Kemelbekovich Smagulov, and Gayane Abdulkhakimovna Atazhanova. "Chemical composition and biological activity of essential oil of Nepeta pannonica." Bulletin of the Karaganda University. “Biology, medicine, geography Series” 104, no. 4 (December 30, 2021): 46–52. http://dx.doi.org/10.31489/2021bmg4/46-52.

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Search for new sources of biologically active substances from plants of local flora is a promising area of modern phytochemical science. The article examines the composition of essential oil samples obtained from Nepeta pannonica, growing in the Karaganda region with the use of gas-chromatography-mass spectrometry method. The differences in the chemical composition of the oil depending by the plant organs have been identified. The main component of essential oil is nepetalactone. For the analysis, a unified method for determining the component composition of essential oils, as well as an Agilent Technologies 7890A chromatograph system with a 5975C inert MSD mass spectrometric detector were used. According to the data, the following substances were identified in the essential oils of the plant — 1,8-cineole, nepetalactone, germacrene D, screening of essential oil of Nepeta pannonica for antimicrobial and analgesic activity.
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26

Lutsenko, T. N., M. V. Kovalenko, and O. Yu Galkin. "Validation of biological activity testing procedure of recombinant human interleukin-7." Ukrainian Biochemical Journal 89, no. 1 (February 21, 2017): 82–89. http://dx.doi.org/10.15407/ubj89.01.082.

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27

Vivcharyk, M. M., O. O. Ilchenko, S. M. Levchenko, and Z. Yu Tkachuk. "Complexation of RNA with mannitol, its spectral characteristics and biological activity." Reports of the National Academy of Sciences of Ukraine, no. 10 (November 16, 2016): 78–83. http://dx.doi.org/10.15407/dopovidi2016.10.078.

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28

Mahabish, Mahabish, and Jaya Verma. "An Assessment on Medicinal Uses and Biological Activity of Bryophyllum Pinnatum." International Journal of Research Publication and Reviews 5, no. 4 (April 11, 2024): 5145–49. http://dx.doi.org/10.55248/gengpi.5.0424.1058.

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29

Kurniawan, Ilham, and Hafizh Zahra. "Review: Gallotannins; Biosynthesis, Structure Activity Relationship, Anti-inflammatory and Antibacterial Activity." Current Biochemistry 8, no. 1 (June 30, 2021): 1–16. http://dx.doi.org/10.29244/cb.8.1.1.

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Tannins are one of the main compounds in plants with potential health benefits. Gallotannin is one of the biologically active tannins groups produced by some medicinal plants. Gallotannins is a hydrolyzable tannin compound biosynthesized through gallic acid, shikimic acid, and pentagalloylglucose pathways. Gallotannins can be separated by cascade solvent extraction procedures, column chromatography, and preparative HPLC. This review focuses on the discussion of biosynthesis and structure-activity relationship of tannins as antibacterial and anti-inflammatory. The structure-activity relationship (SAR) and biological activity of gallotannins is caused by the molecular bonds between gallotannins and certain other compounds, especially proteins, which make complex compounds, change physiological and morphological processes in bacterial cells or tissues. The biological activities of gallotannin include anti-inflammatory, anticancer or antitumour, antiviral, antioxidant, antibacterial, and antidiabetic. This review used the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) method approach in a short, concise, and clear summary about tannins through various references. Keywords: Biological activities, Biosynthesis, Gallotannins
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Novruzov, E. N. "Biologically Active Compounds and Biological Activity of Physalis alkekengi (Solanaceae)." Растительные ресурсы 56, no. 3 (2020): 280–88. http://dx.doi.org/10.31857/s0033994620020077.

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31

Večeřová, Renata. "Colloid silver and its biological activity." Klinická farmakologie a farmacie 30, no. 3 (December 1, 2016): 18–20. http://dx.doi.org/10.36290/far.2016.024.

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32

Yarosh, M., T. Pirog, and O. Skrotska. "Biological activity of microbial polysaccharides." Scientific Works of National University of Food Technologies 26, no. 6 (December 2020): 44–55. http://dx.doi.org/10.24263/2225-2924-2020-26-6-7.

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33

Kaushik, Niranjan, Nitin Kumar, Anoop Kumar, and Umesh K. Singh. "Tetrazoles: Synthesis and Biological Activity." Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 18, no. 1 (September 19, 2018): 3–21. http://dx.doi.org/10.2174/1871522218666180525100850.

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34

Mancianti, Francesca, and Valentina Virginia Ebani. "Biological Activity of Essential Oils." Molecules 25, no. 3 (February 5, 2020): 678. http://dx.doi.org/10.3390/molecules25030678.

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35

Goc, Anna. "Biological activity of vanadium compounds." Open Life Sciences 1, no. 3 (September 1, 2006): 314–32. http://dx.doi.org/10.2478/s11535-006-0029-z.

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AbstractVanadium compounds are characterised by a broad spectrum of action in vivo and in vitro. Their insulin-mimetic activity is manifested in their ability to normalize changes observed in both clinical and experimental diabetes (i.e. hyperglycaemia, hyperlipidaemia, lowered cell sensitivity to insulin) through the regulation of carbohydrate and lipid metabolism and the removal of secondary symptoms of this disease (as e.g. retinopathy, cardiomyopathy, nephropathy). Nevertheless, vanadium is considered to be a toxic element in both cationic and anionic form, although the latter type has more serious side effects. This is accounted for by the faster absorption of anionic forms, although the chemical structure, geometry, and the manner of synthesis of its derivatives also contributes to this elevated toxicity. Besides their antidiabetic properties, vanadium derivatives have also been observed to influence processes related to mitogenic cell responses (apoptosis, proliferation, neoplastic transformation). However, both anti-and pro-neoplastic properties of vanadium are reported.
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Ahmed, Saeed, Mohammad Ashraf ., Abdul Jabbar ., Khalid Hussain Janba ., M. Shafiq Khan ., Nisar-ur-Rahman ., and Munawar Hussain . "Biological Activity of Dipterygium glaucum." Pakistan Journal of Biological Sciences 9, no. 6 (March 1, 2006): 1173–74. http://dx.doi.org/10.3923/pjbs.2006.1173.1174.

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37

Derevianko, S. V., A. V. Vasylchenko, and N. I. Maharramzade. "BIOLOGICAL ACTIVITY OF NICKEL NANOPARTICLES." Agriciltural microbiology 31 (July 7, 2020): 36–43. http://dx.doi.org/10.35868/1997-3004.31.36-43.

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Objective. Study the biological activity of nickel nanoparticles (Ni NPs) against pathogenic viruses and fungi, pathogens of farm animals and plants, investigate their bactericidal and growthregulating properties. Methods. Virological, microbiological and statistical. Virucidal activity of NiNPs was evaluated by the difference of virus titres in the control and under the action of NPs, bactericidal — by the difference of bacterial titres, fungicidal and fungistatic — by the difference of diameters of fungal colonies, growth-regulating — by the difference in leaf blade length and roots ofgerms of winter wheat. The antiviral activity of NPs was determined in the culture of versenalisedembryonic porcine kidney cells. Bactericidal activity was investigated in a liquid digest medium.Fungistatic activity was determined on wort agar. Wheat germs were germinated in Petri dishesaccording to generally accepted methods. The viral titre was calculated by Reed-Muench method.The bacterial titre was determined by seeding the suspensions on agar medium. Statistical processing was performed in Microsoft Office Excel and statsoft STATISTICA 12, using Student's t-test,post-hoc tests: Fisher’s least significant difference test and Duncan’s new multiple range test.Results. It was found that Ni NPs show high virucidal activity against Teschovirus A strainDniprovskyi-34, reducing the virus titre by 2.46 lg TCD50/cm3, and have a chemotherapeutic indexof 4. Ni NPs have low fungistatic activity against Acremonium cucurbitacearum 502, reducing theaverage diameter of colonies by 6.58 to 20.22 %. Regarding Acremonium strictum 048 and Fusarium sp. 072, Ni NPs have a slight stimulating activity, increasing the average diameter of the colonies by 10.18 to 12.44 % and 14.84 to 22.18 %, respectively. Under the action of Ni NPs, the titre ofBacillus subtilis ІМВ В-7023 and Pseudomonas chlororaphis subsp. aureofaciens UKM B-306(2687) upon the cultivation of bacteria in meat-peptone broth significantly (by 80.96 to 82.77 %and 15.67 to 36.39 %, respectively) increases. Ni NPs exhibits growth-promoting properties onwheat germs, increasing the average length of leaf blades and roots by 41.79 and 36.76 %, respectively. Conclusion. According to the study findings, Ni NPs cannot be recommended for the creation of antifungal preparations. Further research is needed to develop Ni NP-based antiviral preparations, virucidal and disinfecting agents, growth- regulating products for cultivated plants, and toincrease the titre of beneficial soil bacteria.
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38

Kamernitskii, A. V., I. G. Reshetova, E. I. Chernoburova, and N. E. Voishvillo. "Biological activity of transformed steroids." Pharmaceutical Chemistry Journal 19, no. 7 (July 1985): 462–66. http://dx.doi.org/10.1007/bf00766682.

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Kamernitskii, A. V., I. S. Levina, L. E. Kulikova, G. V. Nikitina, and V. V. Korkhov. "Biological activity of transformed steroids." Pharmaceutical Chemistry Journal 24, no. 3 (March 1990): 181–84. http://dx.doi.org/10.1007/bf00771697.

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40

Moanta, Anca, Luciana Alexandrescu, Andra Marinescu, Catalina Ionescu, and Madalina Dragoi. "ESSENTIAL OILS WITH BIOLOGICAL ACTIVITY." Annals of the University of Craiova, Series Chemistry 27, no. 2 (December 2021): 27–33. http://dx.doi.org/10.52846/auc.chem.2021.2.03.

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Essential oils from the leaves and the flowers of lavender and from lemon peel were extracted using steam distillation. These oils were separated using thin layer chromatography and characterized using FTIR spectroscopy
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41

Moanta, Anca, Luciana Alexandrescu, Andra Marinescu, Catalina Ionescu, and Madalina Dragoi. "ESSENTIAL OILS WITH BIOLOGICAL ACTIVITY." Annals of the University of Craiova, Series Chemistry 27, no. 2 (December 2021): 27–33. http://dx.doi.org/10.52846/aucchem.2021.2.03.

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Essential oils from the leaves and the flowers of lavender and from lemon peel were extracted using steam distillation. These oils were separated using thin layer chromatography and characterized using FTIR spectroscopy
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42

Vasileva, S. R., M. S. Lytkin, and S. S. Kuzmina. "BIOLOGICAL ACTIVITY OF YAKUT HONEY." Научное обозрение. Биологические науки (Scientific Review. Biological Sciences), no. 4 2019 (2019): 56–60. http://dx.doi.org/10.17513/srbs.1173.

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43

Drobin, Yu D., A. A. Zubenko, L. N. Fetisov, A. N. Bodryakov, M. A. Bodryakova, and K. N. Kononenko. "Biological Activity of Pyridine Derivatives." Veterinaria i kormlenie, no. 2 (April 2019): 31–32. http://dx.doi.org/10.30917/att-vk-1814-9588-2019-2-11.

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44

KAKINUMA, Katsumi. "Biological Activity and Computational Chemistry." Journal of the agricultural chemical society of Japan 67, no. 9 (1993): 1277–80. http://dx.doi.org/10.1271/nogeikagaku1924.67.1277.

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45

WEISER, M., J. FINK-GREMMELS, and L. LEISTNER. "BIOLOGICAL ACTIVITY OF TREMORGENIC MYKOTOXINS." Mycotoxins 1988, no. 1Supplement (1988): 125–26. http://dx.doi.org/10.2520/myco1975.1988.1supplement_125.

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46

Mendel, Ralf R. "Molybdenum: biological activity and metabolism." Dalton Transactions, no. 21 (2005): 3404. http://dx.doi.org/10.1039/b505527j.

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Shaw, Deborah, Ian R. Poxton, and John R. W. Govan. "Biological activity ofBurkholderia (Pseudomonas) cepacialipopolysaccharide." FEMS Immunology & Medical Microbiology 11, no. 2 (April 1995): 99–106. http://dx.doi.org/10.1111/j.1574-695x.1995.tb00095.x.

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48

Giacobino, J. P. "Uncoupling protein 3 biological activity." Biochemical Society Transactions 29, no. 6 (November 1, 2001): 774–77. http://dx.doi.org/10.1042/bst0290774.

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The hypothesis that uncoupling protein 3 (UCP3) is an uncoupling protein involved in heat dissipation is not unequivocally supported. An update of in vitro, ex vivo and in vivo studies testing this hypothesis is presented. Data are provided showing that exercise induces a fatty acid-dependent increase in muscle UCP3 mRNA in humans. The proposed positive correlation between glycolytic capacity and UCP3 level in various muscle-fibre types in the mouse is reassessed. Finally, an association between an intronic polymorphism of UCP3 and adiposity is reported.
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Giacobino, J. P. "Uncoupling protein 3 biological activity." Biochemical Society Transactions 29, no. 5 (October 1, 2001): A98. http://dx.doi.org/10.1042/bst029a098c.

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Gallo, Maria F., Markus J. Steiner, Marcia M. Hobbs, Lee Warner, Denise J. Jamieson, and Maurizio Macaluso. "Biological Markers of Sexual Activity." Sexually Transmitted Diseases 40, no. 6 (June 2013): 447–52. http://dx.doi.org/10.1097/olq.0b013e31828b2f77.

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