Relevant bibliographies by topics / Biological activity

Academic literature on the topic 'Biological activity'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 July 2024

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Journal articles on the topic "Biological activity"

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Levchyck, N. Ya. "BIOLOGICAL ACTIVITY OF SUCCINIC ACIDS." Biotechnologia Acta 10, no. 6 (December 2017): 53–60. http://dx.doi.org/10.15407/biotech10.06.053.

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Tsyganenko, K. S., Ya I. Savchuk, L. T. Nakonechna, and I. M. Kurchenko. "The Biological Activity of Alternaria Species." Mikrobiolohichnyi Zhurnal 80, no. 4 (July 30, 2018): 78–87. http://dx.doi.org/10.15407/microbiolj80.04.078.

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Varbanets, L. D. "SEROLOGICAL AND BIOLOGICAL ACTIVITY OF LIPOPOLYSACCHARIDE." Biotechnologia Acta 8, no. 1 (March 23, 2015): 32–38. http://dx.doi.org/10.15407/biotech8.01.032.

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Varbanets, L. D. "SEROLOGICAL AND BIOLOGICAL ACTIVITY OF LIPOPOLYSACCHARIDE." Biotechnologia Acta 8, no. 1 (March 23, 2015): 56–62. http://dx.doi.org/10.15407/biotech8.01.056.

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Naumenko, K., A. Golovan, and S. Zagorodnya. "Prediction of Biological Activity of Triazoles Derivatives." Mikrobiolohichnyi Zhurnal 82, no. 1 (February 17, 2020): 51–61. http://dx.doi.org/10.15407/microbiolj82.01.051.

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Pirog, T. P. "INFLUENCE OF BIOLOGICAL INDUCTORS ON THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF MICROBIAL METABOLITES." Biotechnologia Acta 16, no. 6 (December 12, 2023): 17–33. http://dx.doi.org/10.15407/biotech16.06.017.

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The increasing antibiotic resistance is a severe concern for humanity. Co-cultivation of microorganisms is a promising method for obtaining new secondary antimicrobial metabolites. An effective strategy for co-cultivation of microorganisms involves the usage of certain biological inductors. The aim of this review is to summarize existing scientific research in the literature related to the influence of physiologically different types of biological inductors on the synthesis and biological activity of microbial secondary metabolites. An analysis of the literature has shown that in such studies, either live or inactivated cells of the inductor are added to the culture medium at significantly lower concentrations compared to the producer cells of the final metabolites, or the supernatant (filtrate) after cultivation of a competitive microorganism is used as an inductor. According to the literature and our own experimental studies, the using inductors is an effective approach not only for intensifying the synthesis of bacteriocins, surfactants, and antibiotics, but also for increasing their biological activity. Additionally, it often leads to the production of novel antimicrobial compounds that are not typical for the producer. However, the mechanisms of effect of inductors on the synthesis of biologically active secondary metabolites require further research, as the literature suggests that their introduction into the cultivation medium of producer does not always lead to an intensification of the synthesis of the final product. Moreover, the biological activity of secondary metabolites depends on the cultivation conditions of the producer, including the presence of biological inductors in the culture medium. Therefore, it is essential to conduct further research on the interaction between producers and competitive microorganisms to regulate the biological activity of the synthesised metabolites. In addition, there is a necessity to search for more cost-effective substrates for the biosynthesis of secondary metabolites, optimize the composition of the culture medium and expand the range of both pro- and eukaryotic inductors.
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Shukurov, C. Y. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW DITHIOCARBAMATE DERIVATIVES." Chemical Problems 18, no. 2 (2020): 174–80. http://dx.doi.org/10.32737/2221-8688-2020-2-174-180.

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Varbanets, L. D., Т. V. Bulyhina, L. А. Pasichnyk, and N. V. Zhytkevich. "Рantoea agglomerans lipopolysaccharides: structure, functional and biological activity." Ukrainian Biochemical Journal 91, no. 1 (January 28, 2019): 5–20. http://dx.doi.org/10.15407/ubj91.01.005.

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Hassanein, M. M. M., F. S. Taha, S. M. Wagdy, and S. F. Hamed. "Evaluation of the biological activity of sunflower hull extracts." Grasas y Aceites 63, no. 2 (April 18, 2012): 184–92. http://dx.doi.org/10.3989/gya.072111.

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Varbanets, L. D. "Structure, Function and Biological Activity of Lipopolysaccharide Lipid A." Mikrobiolohichnyi Zhurnal 78, no. 6 (November 30, 2016): 37–49. http://dx.doi.org/10.15407/microbiolj78.06.037.

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Dissertations / Theses on the topic "Biological activity"

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Lumley, James Andrew. "Molecular modelling of biological activity." Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393752.

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Hariparsad, Sidhika. "Biological activity of Sinularia notanda." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/53497.

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In 1963 the study of marine natural products was just beginning and there were only a handful of public records with only one of these publications reporting a new compound. There has since been 9220 papers published, reporting on 24 662 new compounds. Annually a variety of cembrane diterpenoids with a range of biological activities are reportedly isolated from marine soft coral, and most notably these compounds possess anticancer properties. The investigation of a marine soft coral, Sinularia notanda, for novel bioactive compounds is presented here. The aim was to identify compounds active against key HIV enzymes as well as against cervical cancer, an opportunistic malignancy affecting many HIV positive women in Sub-Saharan Africa. A methanol extract of S. notanda was prepared and the cytotoxicity of the crude extract tested against a cervical cancer (HeLa) cell line using sodium 2,3-bis-(2-methoxy-4-nitro- 5-sulfophenyl)-2H-tetrazolium- 5-carboxanilide (XTT). The crude extract was also tested for HIV-1 protease inhibition using a direct enzyme assay, and antioxidant activity determined using 1,1-diphenyl-2picrylhydrazyl (DPPH). Bioassay guided fractionation, column chromatography and thin layer chromatography were used to identify active fractions from the total extract as well as to isolate biologically active compounds. The isolated compounds were tested for cytotoxic activity against four different cell lines. Nuclear magnetic resonance spectroscopy and x-ray crystallography were used for structure determination. The crude ethyl acetate fraction of S. notanda had a 50% cytotoxic concentration (CC50) of 33.82 ?g/ml, exhibited moderate inhibition of HIV-1 protease (between 40 and 60% inhibition), was unable to inhibit reverse transcriptase and showed antioxidant activity at a concentration (IC50) of 76.15 ?g/ml. In comparison, the crude methanol fraction had a CC50 of 145.80 ?g/ml, showed significantly lower protease inhibition (p < 0.05), and showed antioxidant activity at an IC50 of 27.16 ?g/ml. Extracts from natural sources including soft coral are routinely screened for free radical scavenging ability and the DPPH assay is one of the fastest methods to do so. Free radicals are known to induce oxidative damage to biomolecules which can eventually lead to diseases such as cancer. Oxidative damage can also be caused by HIV infection and oxidative stress levels may be exacerbated by antiretroviral treatment. Free radical scavenging antioxidants can provide protection against the damage caused by reactive oxygen species and are therefore considered as important nutraceuticals. Structural elucidation of a crystal isolated from S. notanda using NMR and x-ray crystallography confirmed a unique cembrane diterpenoid structure. The identified compound [(1R,3R,5S,12R,13S,E)-12-hydroxy-5,9,13-trimethyl-16-methylene-4,14-dioxatricyclo[11.3.2.03,5]octadec-8-en-15-one] showed moderate HIV-1 protease inhibition. This compound was abbreviated as CPD1. A second isolated compound designated E7 was found to be toxic to human leukemic monocyte lymphoma (U937) cells at 25 ?g/ml resulting in cell viability of less than 10%. Structure elucidation of E7 by 1D and 2D NMR as well as mass spectrometric analysis confirmed this compound to be structurally identical to the one isolated as a crystal and it also exhibited similar cytotoxic behaviour. Although this is not the first time CPD1 has been isolated from a coral of the Sinularia genus, data presented in this dissertation represents the first time that the compound was isolated from S. notanda. In Sinularia flexiblis CPD1 was isolated as a ketone (carbon-oxygen double bond at C12) while in the current study it was isolated from S. notanda as an alcohol (hydroxyl group at C12). Ketones are produced from the oxidation of secondary alcohols and the change in functional groups at C12 of CPD1 could be attributed to different organic solvents being used for initial extraction. A third compound was isolated and showed < 50% inhibition of HeLa cell growth and > 90% inhibition of U937 cell growth at 50 ?g/ml. Structure elucidation data identified the compound as 3-caffeoylquinic acid. This compound is not synthesised by the coral itself but is produced by algae that the coral ingested. The cembrane diterpenoid isolated from S. notanda in this study showed moderate inhibition of HIV-1 protease and selective cytotoxicity towards the U937 lymphoma cell line (selectivity index > 2). These responses are not unusual as cembrane diterpenoids with anti-cancer potential are increasingly being isolated from soft corals.
Dissertation (MSc)--University of Pretoria, 2015.
Biochemistry
MSc
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VALLETTA, ELISA. "Metal complexes with biological activity." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266768.

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Cancer is a group a diseases that involves abnormal cell growth with potential to invade or spread to other parts of the body, and it represents the second leading cause of death in developed countries. Cisplatin is one of the most chemotherapeutic drug. In spite of its great efficacy, it shows several side effects and most patients develop a resistance to cisplatin. To overcome the cisplatin resistance, drugs are often administered in combination in order to exploit the drug synergy. After discovery of cisplatin, the research focused on metal complexes less toxic, more effective and that exploit synergistic effect when used in combination. In this work I studied new copper, zinc and vanadium complexes with biological activity. I tested in vitro the studied compounds alone and in combination with drug currently in use against a panel of wild type tumour cell lines and their cisplatin-resistant sublines. I applied chemometric tools such as experimental design (ED) and artificial neural networks (ANNs) to the biochemical data collected. Finally, I used the artificial neural networks to evaluate the cell culture cross-contamination. I selected a new family of copper(II) complexes with 1,10-phenanthroline (phen), 1,10-phenanthrolin-5,6-dione (phendione), and 1,10-phenanthrolin-5,6-diol (phendiol) for the synthesis of new antiproliferative agents. Considering that the DNA is an important target for several cytotoxic metal complexes, I studied the interaction of these Cu(II) complexes with DNA. I tested the ligands and complexes against normal and tumour derived human cell lines. I tested combinations of the studied complexes and cisplatin for their potential synergistic effect against a panel of wild type tumour cell lines and their cisplatin-resistant sublines. I evaluated the selectivity of drug combinations testing the compounds also against ex vivo cultures of human normal cell lines. Considering that the synergy may arise from a chemical reaction among the drugs, I studied the possible formation of new adducts between cisplatin, copper(II) complexes and glutathione. I studied the phospholipid profile of wild type human cancer cell lines and their cisplatin-resistant sublines, given that changes in lipid composition and distribution on the cell membranes have been observed in cancer cells. The in vitro cultured cell lines are widely used as model in biomedical research and the cross-contamination of cell lines represents a highly relevant problem. The ex-post discovery of erroneous results and conclusions led to paper retraction and many high-impact journals started to adopt a zero-tolerance policy requiring confirmation of cell line identity as prerequisite for publication. On the base of these considerations, I decided to develop and validate a method for evaluation of cell culture cross-contamination. I also studied zinc and vanadium complexes. Zinc is an essential metal ion involved in a wide variety of biological processes and several proteins bind zinc for their proper functioning. I studied zinc complexes with the drug methimazole (MeImHS) and its anion (MeImS) in order to provide information for the structure prediction and reactivity of Zn-metalloproteins and -metalloenzymes. Vanadium plays a number of roles in biological systems and vanadocene dichloride was the first discovered vanadium species with antitumour activity. Considering that the mechanism of the anticancer agent vanadocene dichloride is closely related to the biotransformation in the blood plasma, I studied the speciation of vanadocene dichloride in the plasma under physiological conditions. In order to prepare new metal complexes, I also synthesized and characterized a new group of Schiff base ligands derived from salicyladehyde and six natural amino acids. For the analysis of the collected data, I used the ED to set up the experiments for the evaluation of the synergistic effect of drug combinations, and for the study of the possible formation of new adducts between cisplatin, glutathione and studied complexes. I used ANNs for predict and quantify the synergism of drugs, and for the evaluation of cell culture cross-contamination levels.
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Rey, Carrizo Matías. "New polycyclic amines with biological activity." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285111.

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Influenza is a major health problem worldwide, as the periodic pandemics of the 20th century have highlighted. Some countermeasures have been developed and have indeed diminish the devastating effects of the disease, such as modern health care, vaccination and novel medicines. Yet, the threat of a recombinant mutant virus that could affect millions of people and the recently discovered resistance of some virus strains to the current available treatments, render the need for new ways of fighting influenza A virus urgent. In the present dissertation we have taken amantadine as a model, an antiviral drug in disuse at the moment due to the appearance of resistant strains, that targets a viral proton channel named M2. Thus, we have synthesized and evaluated several polycyclic amines as potential wild-type M2 channel blockers and amantadine-resistant mutants, like V27A, as well. We have succeeded in the obtention of highly potent wild-type and V27A inhibitors and most remarkable, some of them exhibited a dual activity on both M2 channels. Noteworthy, among the prepared compounds, a polycyclic guanidine presented the higher activity ever recorded against the V27A mutant. Again working with polycyclic molecules but from a more theoretical point of view, the monomer, dimer and dihydrodimer of a highly strained pyramidalized alkene were synthesized and fully characterized. Importantly, the dimer featured four cyclohexanes in a frozen boat conformation and possessed hydrogen flagpole interactions that were relevant to theoretical organic chemists.
La grip presenta un greu problema arreu del món, com les pandèmies del segle XX han demostrat. S’han pres algunes mesures per lluitar-hi que han realment disminuït els efectes devastadors de la malaltia, com son la hospitalització moderna, la vacunació i les noves medicines. Tot i així, l’amenaça d’un virus recombinant mutant que pugui afectar a milions de persones i la recentment descoberta resistència d’algunes soques del virus als tractaments actuals, han provocat que la necessitat per a noves maneres de lluitar contra la grip A sigui urgent. En la present Tesi, hem pres amantadina com a model, un medicament antiviral actualment en desús degut a l’aparició de soques resistents, que té com a diana un canal de protons del virus anomenat M2. Així doncs, hem sintetitzat i avaluat diverses amines policícliques com a potencials blocadors del canal salvatge M2 i mutants resistents a amantadine, com el V27A, també. Hem tingut èxit en l’obtenció de potents inhibidors del canal salvatge i del V27A i lo més destacable és que alguns han mostrat una activitat dual en ambos canals M2. Cap remarcar que, entre els compostos preparats,una guanidina policíclica va presentar l’activitat més alta mai enregistrada contra el mutant V27A. Seguint amb les molècules policícliques però des d’un punt de vista més teòric, el monomer, dimer i dihidrodimer de un alqué altament piramidalitzat van ser sintetitzats i completament caracteritzats. Cal subratllar que, el dimer posseïa quatre ciclohexans en conformació bot congelat i mostrava interaccions entre els hidrògens flagpole que eren rellevants per als químics orgànics teòrics.
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Thornton, Mark Russell Henry. "The biological activity of sulphated dextrins." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271563.

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Lee, Kok-Onn. "The biological activity of TSH (Thyrotropin)." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335319.

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Holding, Jeremy David. "Cisplatin : protein binding and biological activity." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257185.

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Cox, Kaleb Woodrow. "Synthesis and Biological Activity of Indolinones." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1421165680.

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Catti, Federica. "4,5-dihydropyrazoles : novel chemistry and biological activity." Thesis, St Andrews, 2007. http://hdl.handle.net/10023/351.

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Reed, Anita A. C. "The biological activity of fracture non-unions." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249459.

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Books on the topic "Biological activity"

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1948-, Williams R. Sanders, and Wallace Andrew G. 1935-, eds. Biological effects of physical activity. Champaign, Ill: Human Kinetics Books, 1989.

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Gang, David R., ed. The Biological Activity of Phytochemicals. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-7299-6.

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Pichot, P., P. Berner, R. Wolf, and K. Thau, eds. Biological Psychiatry, Higher Nervous Activity. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-8329-1.

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World Congress of Psychiatry (7th 1983 Vienna, Austria). Biological psychiatry, higher nervous activity. New York: Plenum Press, 1985.

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E, Benfield R., ed. Structures and biological effects. Berlin: Springer-Verlag, 1993.

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Vaughan, D., and R. E. Malcolm, eds. Soil Organic Matter and Biological Activity. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5105-1.

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Sukumaran, Muralidharan. Modelling the biological activity of s.coelicolor. Manchester: UMIST, 1995.

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1949-, Basava Channa, and Anantharamaiah G. M. 1947-, eds. Peptides: Design, synthesis, and biological activity. Boston: Birkhäuser, 1994.

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D, Vaughan, and Malcolm R. E, eds. Soil organic matter and biological activity. Dordrecht: M. Nijhoff/W. Junk, 1985.

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D, Lawson Larry, Bauer Rudolf 1956-, American Chemial Society. Division of Agricultural and Food Chemistry., and American Chemical Society Meeting, eds. Phytomedicines of Europe: Chemistry and biological activity. Washington, DC: American Chemical Society, 1998.

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Book chapters on the topic "Biological activity"

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Batista-Navarro, Riza Theresa. "Biological Activity." In Encyclopedia of Systems Biology, 110. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_1337.

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Likhtenshtein, Gertz I. "Water Basic Properties and Activity." In Biological Water, 1–12. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82503-4_1.

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Saeidnia, Soodabeh, Ahmad Reza Gohari, Azadeh Manayi, and Mahdieh Kourepaz-Mahmoodabadi. "Biological and Pharmacological Activity." In SpringerBriefs in Pharmacology and Toxicology, 41–56. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-25026-7_5.

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Neu, H. C. "Structure-activity relationships: biological." In The Chemistry of β-Lactams, 101–28. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2928-2_3.

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Agrofoglio, L. A., and S. R. Challand. "Biological activity of acyclonucleosides." In Acyclic, Carbocyclic and L-Nucleosides, 136–73. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-007-0816-7_3.

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Dayan, Franck E., and Stephen O. Duke. "Biological Activity of Allelochemicals." In Plant-derived Natural Products, 361–84. New York, NY: Springer US, 2009. http://dx.doi.org/10.1007/978-0-387-85498-4_17.

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Seaman, Fred, Ferdinand Bohlmann, Christa Zdero, and Tom J. Mabry. "Biological Activity of Diterpenes." In Diterpenes of Flowering Plants, 485–92. New York, NY: Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4612-3274-2_5.

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Li, Bin, Li Wang, Weibin Bai, Wei Chen, Fang Chen, and Chi Shu. "Biological Activity of Anthocyanins." In Anthocyanins, 253–78. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-7055-8_13.

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Yoneyama, Koichi, Xiaonan Xie, and Kaori Yoneyama. "Strigolactones and Biological Activity." In Natural Products, 3583–604. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_155.

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Geigert, John. "Indispensable Potency (Biological Activity)." In The Challenge of CMC Regulatory Compliance for Biopharmaceuticals, 407–30. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-31909-9_12.

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Conference papers on the topic "Biological activity"

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Česnek, Michal, and Antonín Holý. "Biological activity of selected guanidinopurines." In XIIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2005. http://dx.doi.org/10.1135/css200507249.

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Novosjolova, Irina, Ērika Bizdēna, Ilona Mandrika, Ramona Petrovska, Jānis Kloviņš, and Māris Turks. "Biological activity profile of triazolylpurine nucleosides." In XVIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414337.

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Dolezal, Martin, Lukas Palek, Zuzana Roslerova, Jiri Kunes, Vladimir Buchta, and Katarina Kralova. "Substituted Pyrazinecarboxamides: Preparation and Biological Activity." In The 8th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2004. http://dx.doi.org/10.3390/ecsoc-8-01972.

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Shevchenko, Tat'yana, Yulia Ustinova, and G. B. Uzunov. "DETERMINATION OF THE BIOLOGICAL ACTIVITY OF SHUNGITE." In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-153.

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Barron, L. D., Lutz Hecht, Z. Q. Wen, Steven J. Ford, and A. F. Bell. "Vibrational Raman optical activity of biological molecules." In Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, edited by Jouko E. Korppi-Tommola. SPIE, 1993. http://dx.doi.org/10.1117/12.146174.

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Barron, L. D., A. R. Gargaro, Lutz Hecht, Z. Q. Wen, and W. Hug. "Vibrational Raman optical activity of biological molecules." In Moscow - DL tentative, edited by Sergei A. Akhmanov and Marina Y. Poroshina. SPIE, 1991. http://dx.doi.org/10.1117/12.57291.

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Safitri, Wulan Nur, Vina Maulidya, Agung Rahmadani, and Laode Rijai. "Synthesis and biological activity of chlorochalcone derivative." In INTERNATIONAL CONFERENCE ON ENERGY AND ENVIRONMENT (ICEE 2021). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0059499.

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Avila, Carolina Martins, Ilton B. D. de Castro, Karin J. P. Rocha, Carmen V. Ferreira, and Ronaldo A. Pilli. "Synthesis and Biological Activity of Fostriecin Analogs." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0166-1.

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Winterfeldt, E. "Steroidal Pyrazines, synthetic Advances and biological Activity." In The 2nd International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 1998. http://dx.doi.org/10.3390/ecsoc-2-01692.

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Molebny, Vasyl V., and Valeri V. Marienko. "Optical activity measurement of multicomponent biological substances." In Europto Biomedical Optics '93, edited by Nathan I. Croitoru and Riccardo Pratesi. SPIE, 1994. http://dx.doi.org/10.1117/12.167324.

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Reports on the topic "Biological activity"

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Peter Pryfogle. Monitoring Biological Activity at Geothermal Power Plants. Office of Scientific and Technical Information (OSTI), September 2005. http://dx.doi.org/10.2172/911257.

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CORPS OF ENGINEERS OMAHA NE. Biological Opinion Compliance Report and Permit Activity Report. Fort Belvoir, VA: Defense Technical Information Center, March 1999. http://dx.doi.org/10.21236/ada382674.

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Katz, Christopher E., and Jeffrey Aube. Synthesis, Conformational Analysis, and Biological Activity of Proposed Vitronectin Antagonists. Fort Belvoir, VA: Defense Technical Information Center, April 2001. http://dx.doi.org/10.21236/ada395699.

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Cho, Tae Joon, Vincent A. Hackley, Feng Yi, David A. LaVan, Vytas Reipa, Alessandro Tona, Bryant C. Nelson, Christopher M. Sims, and Natalia Farkas. Preparation, Characterization, and Biological Activity of Stability-Enhanced Polyethyleneimine-Conjugated Gold Nanoparticles (Au-PEI@NIST) for Biological Application. National Institute of Standards and Technology, September 2021. http://dx.doi.org/10.6028/nist.sp.1200-29.

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Peter R. Jaffe, John Komlos, Derick Brown. Hydrogen as an Indicator to Assess Biological Activity During Trace-Metal Bioremediation. Office of Scientific and Technical Information (OSTI), September 2005. http://dx.doi.org/10.2172/850337.

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Abhijeet P. Borole, Choo Y. Hamilton, Karen Miller, Brian Davison, Matthew Grossman, and Robert Shong. Improving Enzyme Activity and Broadening Selectivity for Biological Desulfurization and Upgrading of Petroleum Feedstocks. Office of Scientific and Technical Information (OSTI), May 2003. http://dx.doi.org/10.2172/812037.

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Pryfogle, Peter Albert. Comparison of Selective Culturing and Biochemical Techniques for Measuring Biological Activity in Geothermal Process Fluids. Office of Scientific and Technical Information (OSTI), September 2000. http://dx.doi.org/10.2172/911015.

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Samish, Michael, K. M. Kocan, and Itamar Glazer. Entomopathogenic Nematodes as Biological Control Agents of Ticks. United States Department of Agriculture, September 1992. http://dx.doi.org/10.32747/1992.7568104.bard.

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This research project was aimed to create a basis for the use of entomopathogenic nematodes (Steinernematidae an Heterorhabditidae) for biological control of ticks. The specific objectives were to determinate: 1) Nematode virulence to various. 2) Host-parasite interactions of nametodes and ticks. 3) Effect of environmental factors of tick habitats on nematode activity. 4) To test nematodes (anti tick activity) in defined field trials. Throughout the project 12 nematode strains from five species were tested in laboratory assays against all developmental stages of eight tick species. All tick species were found susceptible to nematode infection. The nematode strains the IS-5 and IS-12 of Heterorhabditis bacteriophora were found to be the most virulent. Engorged adults, particularly females, were the most susceptible stages. Despite the high susceptibility, ticks are not suitable hosts for nematode development and propagation. Entomopathogenic namatodes enter ticks and kill them by releasing the symbiotic bacteria from their foregut. Under favorable conditions, i.e. moist soil, moderate temperature (22-27oC) and sandy soil, nematode efficacy against B. annulatus engorged females was very high (>5% w/w) and high animal manure concentration in soil adversely effect nematode efficacy. In field trails, nematodes were effective when soil moisture was maintained at high levels. The results indicate that under favorable conditions the nematodes show promise as a biological control method for ticks. However, we still face several potential obstacles to the use of nematodes under less favorable conditions.
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James J. Celentano, James J. Celentano. How Do Ion Channels Really Work, Fundamentals of Biological Electrical Activity, the Bits of the Brain? Experiment, December 2016. http://dx.doi.org/10.18258/8757.

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Spiers, Donald, Arieh Gertler, Harold Johnson, and James Spain. An In Vitro and In Vivo Investigation of the Diverse Biological Activities of Bovine Placental Lactogen. United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568087.bard.

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In order to understand the structure-function relationship of bovine placental lactogen (bPL) and initiate production of material for in vivo testing, 28 different bPL analogues were prepared by either truncation or site-directed mutagenesis. The effect of these mutations was determined by measuring binding capacity, ability to homodimerize extracellular domains (ECDs) of several lactogenic and somatogenic receptors, and by in vitro bioassays. Two analogues were prepared in large amounts for in vivo studies. These studies (a) identified the residues responsible for the somatogenic activity of bPL (K73, G133, T188) and for both lactogenic and somatogenic activity (N-terminus, K185, Y190); (b) allowed preparation of bPL analogues with selectively abolished or reduced somatogenic activity; and (c) provided a tool to understand the kinetic difference between lactogenic and somatogenic receptors. In vivo studies using rodent and dairy models showed that bovine growth hormone (bGH) is superior to bPL in stimulating growth and lactation. Likewise, bGH has greater somatogenic activity in different age groups and thermal environments. Initial studies of bPL analog T188 suggest that its lactogenic potential is superior to bGH. Effective experimental models have now been developed and tested for analysis of new bPL analogs.
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