Relevant bibliographies by topics / Biokonjugation

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Biokonjugation'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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Journal articles on the topic "Biokonjugation"

1

Zhang, Chi, Ekaterina V. Vinogradova, Alexander M. Spokoyny, Stephen L. Buchwald, and Bradley L. Pentelute. "Arylierungschemie für die Biokonjugation." Angewandte Chemie 131, no. 15 (February 15, 2019): 4860–92. http://dx.doi.org/10.1002/ange.201806009.

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van Berkel, Sander S., Mark B. van Eldijk, and Jan C. M. van Hest. "Staudinger-Ligation als Methode zur Biokonjugation." Angewandte Chemie 123, no. 38 (September 2, 2011): 8968–89. http://dx.doi.org/10.1002/ange.201008102.

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3

Schroedter, Andrea, and Horst Weller. "Ligandendesign und Biokonjugation kolloidaler Gold-Nanopartikel." Angewandte Chemie 114, no. 17 (September 2, 2002): 3346–50. http://dx.doi.org/10.1002/1521-3757(20020902)114:17<3346::aid-ange3346>3.0.co;2-r.

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4

Ohata, Jun, Samuel C. Martin, and Zachary T. Ball. "Metallvermittelte Funktionalisierung natürlicher Peptide und Proteine: Biokonjugation mit Übergangsmetallen." Angewandte Chemie 131, no. 19 (March 4, 2019): 6238–64. http://dx.doi.org/10.1002/ange.201807536.

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5

Dibowski, Harald, and Franz P Schmidtchen. "Biokonjugation von Peptiden durch Palladium-katalysierte C-C-Kreuzkupplung in Wasser." Angewandte Chemie 110, no. 4 (February 16, 1998): 487–89. http://dx.doi.org/10.1002/(sici)1521-3757(19980216)110:4<487::aid-ange487>3.0.co;2-s.

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6

Kasper, Marc‐André, Maria Glanz, Andreas Stengl, Martin Penkert, Simon Klenk, Tom Sauer, Dominik Schumacher, et al. "Cysteinselektive phosphonamidatbasierte Elektrophile für modulare Biokonjugationen." Angewandte Chemie 131, no. 34 (April 29, 2019): 11751–56. http://dx.doi.org/10.1002/ange.201814715.

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7

Ziegler, Thomas, Sonja Gerling, and Martin Lang. "Herstellung von Biokonjugaten durch Ugi-Reaktion." Angewandte Chemie 112, no. 12 (June 16, 2000): 2202–5. http://dx.doi.org/10.1002/1521-3757(20000616)112:12<2202::aid-ange2202>3.0.co;2-6.

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8

Barcikowski, S., C. Rehbock, U. Taylor, W. Kues, and D. Rath. "Durchflussreaktor zur Synthese von Nanopartikel-Biokonjugaten für die Reproduktionsbiologie." Chemie Ingenieur Technik 84, no. 8 (July 25, 2012): 1187. http://dx.doi.org/10.1002/cite.201250040.

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9

Kühnle, Romina I., and Hans G. Börner. "Calciumionen als Schalter zur reversiblen Steuerung der Sekundär- und Quartärstrukturen in Biokonjugaten." Angewandte Chemie 123, no. 19 (April 8, 2011): 4592–95. http://dx.doi.org/10.1002/ange.201100141.

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Dissertations / Theses on the topic "Biokonjugation"

1

Schroedter, Andrea. "Biokonjugation und Selbstorganisation von Gold- und Halbleiter-Nanokristallen." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966302699.

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2

Castillo, Gómez Juan Daniel [Verfasser]. "Kopplungsfähige Thiocarbamoylbenzamidine als Liganden zur Biokonjugation von Rhenium und Technetium / Juan Daniel Castillo Gómez." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1070820024/34.

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Roth, Patrick [Verfasser], and Ulrich [Gutachter] Schatzschneider. "Metalltricarbonyl-basierte CO-releasing molecules (CORMs): Variation der Freisetzungskinetik und Biokonjugation / Patrick Roth ; Gutachter: Ulrich Schatzschneider." Würzburg : Universität Würzburg, 2021. http://d-nb.info/1236547950/34.

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4

Steinmeyer, Jeannine [Verfasser], and H. A. [Akademischer Betreuer] Wagenknecht. "Biokonjugation eines Farbstoffpaares als fluoreszentes Modul für siRNA, Aptamere und boronsäuremodifizierte DNA / Jeannine Steinmeyer ; Betreuer: H.-A. Wagenknecht." Karlsruhe : KIT-Bibliothek, 2018. http://d-nb.info/1170230490/34.

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5

Horstmann, Benjamin [Verfasser], Markus [Akademischer Betreuer] Biesalski, Franz-Josef [Akademischer Betreuer] Meyer-Almes, Harald [Akademischer Betreuer] Kolmar, and Christina [Akademischer Betreuer] Thiele. "Stimulussensitive Polymersysteme zur Biokonjugation an Proteinen am Beispiel der Histondeacetylase-ähnliche Amidohydrolase / Benjamin Horstmann. Betreuer: Markus Biesalski ; Franz-Josef Meyer-Almes ; Harald Kolmar ; Christina Thiele." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2015. http://d-nb.info/1112044299/34.

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6

Zarafshani, Zoya. "Chain-end functionalization and modification of polymers using modular chemical reactions." Phd thesis, Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2012/5972/.

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Taking advantage of ATRP and using functionalized initiators, different functionalities were introduced in both α and ω chain-ends of synthetic polymers. These functionalized polymers could then go through modular synthetic pathways such as click cycloaddition (copper-catalyzed or copper-free) or amidation to couple synthetic polymers to other synthetic polymers, biomolecules or silica monoliths. Using this general strategy and designing these co/polymers so that they are thermoresponsive, yet bioinert and biocompatible with adjustable cloud point values (as it is the case in the present thesis), the whole generated system becomes "smart" and potentially applicable in different branches. The applications which were considered in the present thesis were in polymer post-functionalization (in situ functionalization of micellar aggregates with low and high molecular weight molecules), hydrophilic/hydrophobic tuning, chromatography and bioconjugation (enzyme thermoprecipitation and recovery, improvement of enzyme activity). Different α-functionalized co/polymers containing cholesterol moiety, aldehyde, t-Boc protected amine, TMS-protected alkyne and NHS-activated ester were designed and synthesized in this work.
In dieser Arbeit wurden mittels der ATRP Methode sowie durch Benutzung funktioneller Initiatoren verschiedene Funktionalitäten an der α- und ω-Position der synthetischen Polymere (Kettenenden) eingeführt. Diese funktionalisierten Polymere können durch modulare synthetische Methoden wie z.B. die “Klick-Zykloaddition” (kupferkatalysiert oder auch kupferfreie Methoden möglich), Amidierung mit anderen synthetischen Polymeren oder Biomolekülen, oder auch mit Silikatmonolithen gekuppelt werden. Den beschriebenen Strategien folgend und unter Benutzung von thermoresponsiven, bioinerten und biokompartiblen (Co-) Polymeren mit einstellbaren Trübungspunkten können mittels Temperaturänderungen leicht steuerbare, „smarte“ Polymersysteme für verschiedene Anwendungen hergestellt werden. Im Rahmen dieser Arbeit wurden speziell Anwendungen wie die Postfunktionalisierung (in situ Funktionalisierung mizellarer Aggregate mit Molekülen, die sowohl niedrige als auch höhere Molekulargewichte aufweisen), hydrophiles/hydrophobes Tuning von Polymeren, Chromatographie an Polymeren sowie Biokonjugation von Polymeren (Enzymthermoprezipitation und -Gewinnung, Enzymaktivitätsmodifizierung) genauer untersucht. Es wurden verschiedene α-funktionalisierte (Co-)Polymere, die Cholesterol, Aldehyde, t-Boc geschützte Amine, TMS-geschützte Alkine und NHS-aktivierte Ester entwickelt und hergestellt und mittels passender ATRP Initiatoren eingeführt.
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Ennen, Franka, Susanne Boye, Albena Lederer, Mihaela Cernescu, Hartmut Komber, Bernhard Brutschy, Brigitte Voit, and Dietmar Appelhans. "Biohybrid structures consisting of biotinylated glycodendrimers and proteins: influence of the biotin ligand’s number and chemical nature on the biotin–avidin conjugation." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A36421.

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We present the bioconjugation of avidin as a central and/or bridging building block with mono-, bi- and tetravalent biotinylated glycodendrimers to fabricate defined supramolecular nanostructures for future (bio)medical applications. For this purpose mono-, bi- and tetravalent biotinylated glycodendrimers, decorated with short alkyl-linked or long PEG-linked biotin ligands, were synthesized and characterized by NMR, IR and mass spectrometry and HABA displacement assay. Various techniques (UV/Vis, DLS, TEM, LILBID-MS and AF4) were used in order to obtain information about the structural properties of different conjugates of avidin and mono-, bi- and tetravalent biotinylated glycodendrimers. The biotin ligand’s spacer length, its chemical structure and the degree of biotin functionalization are essential parameters in the formation of nanostructures with avidin having a controlled composition and size dimension up to 100 nm. Biohybrid structures with avidin as a central unit require monovalent glycodendrimers with PEG-linked biotin, while bi- and tetravalent glycodendrimers with short alkyl-linked biotin ligands are more efficient than their counterparts with longer PEG–biotin ligands in the fabrication of defined biohybrid structures (∅ up to 100 nm) with avidin as a bridging unit. The most dominating key issue, combined with other conjugation issues, is the optimal ligand–receptor stoichiometry to fabricate biohybrid structures with diameter of <20, <30 or up to 100 nm.
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Ferl, Sandra, Gerd Wunderlich, René Smits, Alexander Hoepping, Anne Naumann, and Jörg Kotzerke. "Synthesis of a new HYNIC-DAPI derivative for labelling with ⁹⁹ᵐTechnetium and its in vitro evaluation in an FRTL5 cell line." Royal Society of Chemistry, 2015. https://tud.qucosa.de/id/qucosa%3A36278.

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4′,6-Diamidine-2-phenylindole (DAPI) is a common fluorochrome that is able to bind to deoxyribonucleic acid (DNA) with distinct, sequence-dependent enhancement of fluorescence. This work presents the synthesis of a new multifunctional compound that includes the fluorescent dye as a ⁹⁹ᵐTechnetium (⁹⁹ᵐTc) carrier. A new technique for the bioconjugation of DAPI with 6-hydrazinonicotinic acid (HYNIC) through an amide linkage was developed. The radiolabelling was performed with HYNIC as a chelator and N-IJ2-hydroxy-1,1-bisIJhydroxymethyl)ethyl)glycine (tricine) as a coligand. Furthermore, experimental evidence showed that ⁹⁹ᵐTc complexes with DAPI as DNA-binding moieties are detectable in living Fischer rat thyroid follicular cell line 5 (FRTL5) and their nuclei. The investigations indicated further that the new HYNIC-DAPI derivative is able to interact with double-stranded DNA. This establishes the possibility of locating ⁹⁹ᵐTc in close proximity to biological structures of living cells, of which especially the genetic information-carrying cell compartments are at the centre of interest. In this context, further investigations are related to the radiotoxic effects of DNA-bound ⁹⁹ᵐTc-HYNIC-DAPI derivatives and dosimetric calculations.
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9

Guhrenz, Chris, Vladimir Sayevich, Florian Weigert, Eileen Hollinger, Annett Reichhelm, Ute Resch-Genger, Nikolai Gaponik, and Alexander Eychmüller. "Transfer of Inorganic-Capped Nanocrystals into Aqueous Media." American Chemical Society, 2017. https://tud.qucosa.de/id/qucosa%3A33352.

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We report on a novel and simple approach to surface ligand design of CdSe-based nanocrystals (NCs) with biocompatible, heterobifunctional polyethylene glycol (PEG) molecules. This method provides high transfer yields of the NCs into aqueous media with preservation of the narrow and symmetric emission bands of the initial organic-capped NCs regardless of their interior crystal structure and surface chemistry. The PEG-functionalized NCs show small sizes, high photoluminescence quantum yields of up to 75%, as well as impressive optical and colloidal stability. This universal approach is applied to different fluorescent nanomaterials (CdSe/CdS, CdSe/CdSCdxZn1–xS, and CdSe/CdS/ZnS), extending the great potential of organic-capped NCs for biological applications.
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10

Baumann, Alice Leonie. "Electrophilic Phosphonothiolates for Cysteine-selective Bioconjugations." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/22194.

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In dieser Arbeit wurden ungesättigte Vinyl- und Ethynylphosphonothiolate hergestellt und als Linker für Cystein-selektive Proteinmodifikationen verwendet. Zunächst wurde, ausgehend von ungesättigten Phosphoniten und elektrophilen Disulfiden als Startmaterialien, eine Syntheseroute zur Herstellung von ungesättigten Phosphonothiolaten entwickelt. Die hohe Chemoselektivität dieser Reaktion ermöglichte die Einführung von Vinylphosphonothiolaten auf ungeschützten Modellpeptiden und dem Protein Ubiquitin. Es konnte gezeigt werden, dass ungesättigte Phosphonothiolate unter neutralen bis leicht basischen Bedingungen selektiv mit Thiolen reagieren und sich daher als Linker für Cystein-selektive Proteinmodifikationen eignen. Die Vielseitigkeit der hier entwickelten Biokonjugationsmethode wurde in drei Anwendungen demonstriert. Ausgehend von dem Vinylphoshonothiolat-modifizierten Ubiquitin konnten homogene Ubiquitin-Protein-Konjugate erzeugt werden; zum einen ein nicht hydrolysierbares Diubiquitin-Konjugat und zum anderen ein Ubiquitin-α–Synuclein-Konjugat. Des Weiteren wurden ungesättigte Phosphonothiolate als Linker in Antikörper-Wirkstoff-Konjugaten getestet. Hier zeigte sich, dass insbesondere Vinylphosphonothiolat-Linker Potential zur Herstellung von stabilen Antikörper-Konjugaten aufweisen. Schließlich wurden Vinylphosphonothiolate als Linker verwendet, um sowohl Chaperon-bindende Antikörper als auch Deubiquitinasen (DUBs) mit photoreaktiven Crosslinkern auszustatten um damit dynamische Protein-Interaktionen zu untersuchen. Insgesamt ermöglicht das hier entwickelte Verfahren die chemoselektive Umwandlung von elektrophilen Disulfiden in elektrophile Vinyl- und Ethynylphosphonothiolate, wodurch Reaktivität für eine Thioladdition induziert wird. Dadurch können zwei komplexe, thiolhaltige Moleküle selektiv konjugiert werden, was insbesondere für die Herstellung von homogen modifizierten Peptid- und Proteinkonjugaten von Bedeutung ist.
In this work, unsaturated vinyl- and ethynylphosphonothiolates were synthesised and used as linkers for cysteine-selective protein modifications. First, a synthetic route for the generation of unsaturated phosphonothiolates was developed, using unsaturated phosphonites and electrophilic disulfides as starting materials. The high chemoselectivity of this reaction enabled the introduction of vinylphosphonothiolates on unprotected model peptides and the protein ubiquitin. It could then be shown that unsaturated phosphonothiolates react selectively with thiols under neutral to slightly basic conditions and are therefore suitable as linkers for cysteine-selective protein modifications. The versatility of the herein developed bioconjugation method was demonstrated in three applications. First, starting from the vinylphosphonothiolate-modified ubiquitin, homogeneous ubiquitin-protein conjugates could be generated, in particular a non-hydrolyzable diubiquitin conjugate and a ubiquitin-α-synuclein conjugate. Second, the suitability of unsaturated phosphonothiolates as linkers for the generation of stable antibody-drug conjugates was tested. Vinylphosphonothiolate linkers thereby showed potential to produce stable antibody conjugates. Finally, vinylphosphonothiolates were used as linkers to conjugate both chaperone-binding antibodies and deubiquitinases (DUBs) to photo-reactive crosslinkers in order to investigate dynamic protein interactions. Overall, the herein developed methodology enables the chemoselective conversion of electrophilic disulfides into electrophilic vinyl- and ethynylphosphonothiolates, which in turn react selectively with thiols. As a result, two complex, thiol-containing molecules can be selectively conjugated, which is particularly important for the production of homogeneously modified peptide and protein conjugates.
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