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Journal articles on the topic 'BioInorganic Chemistry, Medicinal Chemistry'

Author: Grafiati

Published: 6 September 2023

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1

Nurchi, Valeria M., and Guido Crisponi. "Editorial: Applications of Medicinal Bioinorganic Chemistry." Current Medicinal Chemistry 25, no. 1 (January 22, 2018): 3–4. http://dx.doi.org/10.2174/092986732501180122141500.

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2

Schatzschneider, Ulrich. "Bioinorganic Medicinal Chemistry. Edited by Enzo Alessio." Angewandte Chemie International Edition 50, no. 46 (October 21, 2011): 10765–67. http://dx.doi.org/10.1002/anie.201104828.

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3

Schatzschneider, Ulrich. "Bioinorganic Medicinal Chemistry. Herausgegeben von Enzo Alessio." Angewandte Chemie 123, no. 46 (October 21, 2011): 10953–55. http://dx.doi.org/10.1002/ange.201104828.

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4

Kostova, Irena. "Editorial to the Special Issue: “Synthesis of Organic Ligands and Their Metal Complexes in Medicinal Chemistry”." Molecules 27, no. 11 (June 6, 2022): 3644. http://dx.doi.org/10.3390/molecules27113644.

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5

Cohen, Seth M. "New approaches for medicinal applications of bioinorganic chemistry." Current Opinion in Chemical Biology 11, no. 2 (April 2007): 115–20. http://dx.doi.org/10.1016/j.cbpa.2007.01.012.

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6

Reedijk, Jan. "Bioinorganic chemistry." Science of Nature 74, no. 2 (February 1987): 71–77. http://dx.doi.org/10.1007/bf00366080.

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7

Erxleben, Andrea. "Transition metal salen complexes in bioinorganic and medicinal chemistry." Inorganica Chimica Acta 472 (March 2018): 40–57. http://dx.doi.org/10.1016/j.ica.2017.06.060.

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8

Ravichandran, S., R. M. Madhumitha Sri, Mahrukh Mehraj, and Chundru Sowmya. "The importance of transition metals as drug." International Journal of Clinical Biochemistry and Research 9, no. 1 (March 15, 2022): 1–3. http://dx.doi.org/10.18231/j.ijcbr.2022.001.

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The last few decades have seen enormous advances in the area of bioinorganic chemistry, attracting scientists from various disciplines including chemistry, biology, agriculture and medicine. Metals are very important constituents preferred by nature that function in bio-chemical method for living organisms. Metal complexes are essential in the area of catalysis, material science, photochemistry and bio systems. Medicinal chemistry may exploit the unique feature of metal ions in concern with design of new drugs. The recent advancement in emerging field of inorganic chemistry, the act of transition metal complexes as therapeutic compound has becoming increasingly important. From the survey of literature inorganic chemistry have made possible formation that leads to number of transition metal complexes having organiclig and can be used as therapeutic agent. The present review paper focus the scope and recent progress in the area of bioinorganic chemistry with new opportunities to the synthesis of metal-based drugs.

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9

Nurchi, Valeria M. "Medicinal bio-inorganic chemistry: papers from the Third International Summer School of Bioinorganic Medicinal Chemistry, Cagliari, Italy." Journal of Inorganic Biochemistry 199 (October 2019): 110798. http://dx.doi.org/10.1016/j.jinorgbio.2019.110798.

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10

Bhabak, Krishna P., Bhaskar J. Bhuyan, and Govindasamy Mugesh. "Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes." Dalton Transactions 40, no. 10 (2011): 2099. http://dx.doi.org/10.1039/c0dt01057j.

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11

Guo, Zijian, and Jing Zhao. "Editorial overview: Bioinorganic chemistry: Bio-medicinal functions of metal complexes." Current Opinion in Chemical Biology 43 (April 2018): A4—A5. http://dx.doi.org/10.1016/j.cbpa.2018.02.013.

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12

Andrade, Marta A., and Luísa M. D. R. S. Martins. "Novel Chemotherapeutic Agents - The Contribution of Scorpionates." Current Medicinal Chemistry 26, no. 41 (January 8, 2020): 7452–75. http://dx.doi.org/10.2174/0929867325666180914104237.

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: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

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13

Constable, Edwin C., Catherine E. Housecroft, Marc Creus, Karl Gademann, Bernd Giese, Thomas R. Ward, Wolf-D. Woggon, and Antoinette Chougnet. "Bioorganic and Bioinorganic Chemistry." CHIMIA International Journal for Chemistry 64, no. 12 (December 15, 2010): 846–54. http://dx.doi.org/10.2533/chimia.2010.846.

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14

Chayen, J. "Principles of bioinorganic chemistry." Cell Biochemistry and Function 13, no. 2 (June 1995): 153–54. http://dx.doi.org/10.1002/cbf.290130214.

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15

Vignais, P. "The bioinorganic chemistry of nickel." Biochimie 72, no. 5 (May 1990): 375–76. http://dx.doi.org/10.1016/0300-9084(90)90036-g.

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16

Keppler, Bernhard, Markus Galanski, and Annette Rompel. "Editorial: Topics in Bioinorganic Chemistry." Chemistry & Biodiversity 5, no. 8 (August 2008): 1435–36. http://dx.doi.org/10.1002/cbdv.200890133.

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17

Dawson, John H. "Bioinorganic chemistry: principles and practice." Chemistry & Biology 2, no. 3 (March 1995): 137–38. http://dx.doi.org/10.1016/1074-5521(95)90067-5.

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18

Rybak-Akimova, Elena. "Bioinorganic chemistry: A short course." Applied Biochemistry and Biotechnology 104, no. 2 (February 2003): 157–58. http://dx.doi.org/10.1007/s12010-003-0002-5.

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19

Notaro, Anna, and Gilles Gasser. "First Workshop on Metals in Medicine (2019): Translational Research in Medicinal Bioinorganic Chemistry." ChemBioChem 21, no. 19 (June 26, 2020): 2706–7. http://dx.doi.org/10.1002/cbic.202000329.

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20

Tyeklar, Zoltan, and Kenneth D. Karlin. "Copper-dioxygen chemistry: a bioinorganic challenge." Accounts of Chemical Research 22, no. 7 (July 1989): 241–48. http://dx.doi.org/10.1021/ar00163a003.

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21

Orzeł, Łukasz, Maria Oszajca, Justyna Polaczek, Dominika Porębska, Rudi van Eldik, and Grażyna Stochel. "High-Pressure Mechanistic Insight into Bioinorganic NO Chemistry." Molecules 26, no. 16 (August 16, 2021): 4947. http://dx.doi.org/10.3390/molecules26164947.

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Pressure is one of the most important parameters controlling the kinetics of chemical reactions. The ability to combine high-pressure techniques with time-resolved spectroscopy has provided a powerful tool in the study of reaction mechanisms. This review is focused on the supporting role of high-pressure kinetic and spectroscopic methods in the exploration of nitric oxide bioinorganic chemistry. Nitric oxide and other reactive nitrogen species (RNS) are important biological mediators involved in both physiological and pathological processes. Understanding molecular mechanisms of their interactions with redox-active metal/non-metal centers in biological targets, such as cofactors, prosthetic groups, and proteins, is crucial for the improved therapy of various diseases. The present review is an attempt to demonstrate how the application of high-pressure kinetic and spectroscopic methods can add additional information, thus enabling the mechanistic interpretation of various NO bioinorganic reactions.

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22

Armstrong, Andrea F., and John F. Valliant. "The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy." Dalton Transactions, no. 38 (2007): 4240. http://dx.doi.org/10.1039/b709843j.

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23

Iakovidis, Isidoros, Ioannis Delimaris, and Stylianos M. Piperakis. "Copper and Its Complexes in Medicine: A Biochemical Approach." Molecular Biology International 2011 (June 15, 2011): 1–13. http://dx.doi.org/10.4061/2011/594529.

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The fundamental role of copper and the recognition of its complexes as important bioactive compounds in vitro and in vivo aroused an ever-increasing interest in these agents as potential drugs for therapeutic intervention in various diseases. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new opportunities offered by the flourishing technologies of medicinal chemistry, is creating an exciting scenario for the development of a novel generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to summarize all the available-to-date information on these issues.

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24

Kravchik, M. V., I. A. Novikov, S. Yu Petrov, and S. E. Avetisov. "Bioinorganic chemistry of open-angle glaucoma: A review." Journal of Trace Elements in Medicine and Biology 62 (December 2020): 126652. http://dx.doi.org/10.1016/j.jtemb.2020.126652.

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25

Kola, Arian, Federico Nencioni, and Daniela Valensin. "Bioinorganic Chemistry of Micronutrients Related to Alzheimer’s and Parkinson’s Diseases." Molecules 28, no. 14 (July 17, 2023): 5467. http://dx.doi.org/10.3390/molecules28145467.

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Metal ions are fundamental to guarantee the regular physiological activity of the human organism. Similarly, vitamins play a key role in many biological functions of the metabolism, among which are coenzymes, redox mediators, and antioxidants. Due to their importance in the human organism, both metals and vitamins have been extensively studied for their involvement in neurodegenerative diseases (NDs). However, the full potential of the interaction between vitamins and metal ions has not been fully explored by researchers yet, and further investigation on this topic is needed. The aim of this review is to provide an overview of the scientific literature on the implications of vitamins and selected metal ions in two of the most common neurodegenerative diseases, Alzheimer’s and Parkinson’s disease. Furthermore, vitamin–metal ion interactions are discussed in detail focusing on their bioinorganic chemistry, with the perspective of arousing more interest in this fascinating bioinorganic field.

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26

Maurya, R. C., and H. Singh. "Oxovanadium(IV) Complexes Involving O,O‐Donor Environment of Bioinorganic and Medicinal Relevance." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 34, no. 2 (March 1, 2004): 269–90. http://dx.doi.org/10.1081/sim-120028301.

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27

Thorp, H. Holden. "Bioinorganic chemistry and drug design: here comes zinc again." Chemistry & Biology 5, no. 6 (June 1998): R125—R127. http://dx.doi.org/10.1016/s1074-5521(98)90166-1.

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28

Meyer, Franc. "Bioinorganic Chemistry. A Short Course. Von Rosette M. Roat-Malone." Angewandte Chemie 115, no. 48 (December 15, 2003): 6104. http://dx.doi.org/10.1002/ange.200385959.

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29

Bryan, R. F. "Bioinorganic chemistry: inorganic elements in the chemistry of lifr by W. Kaim and B. Swederski." Acta Crystallographica Section B Structural Science 51, no. 2 (April 1, 1995): 264. http://dx.doi.org/10.1107/s010876819509985x.

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30

Hecel, Aleksandra, Paulina Kolkowska, Karolina Krzywoszynska, Agnieszka Szebesczyk, Magdalena Rowinska-Zyrek, and Henryk Kozlowski. "Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy." Current Medicinal Chemistry 26, no. 4 (April 1, 2019): 624–47. http://dx.doi.org/10.2174/0929867324666170920125943.

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Silver is a non-essential element with promising antimicrobial and anticancer properties. This work is a detailed summary of the newest findings on the bioinorganic chemistry of silver, with a special focus on the applications of Ag+ complexes and nanoparticles. The coordination chemistry of silver is given a reasonable amount of attention, summarizing the most common silver binding sites and giving examples of such binding motifs in biologically important proteins. Possible applications of this metal and its complexes in medicine, particularly as antibacterial and antifungal agents and in cancer therapy, are discussed in detail. The most recent data on silver nanoparticles are also summarized.

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31

Tsantis, Sokratis T., Demetrios I. Tzimopoulos, Malgorzata Holynska, and Spyros P. Perlepes. "Oligonuclear Actinoid Complexes with Schiff Bases as Ligands—Older Achievements and Recent Progress." International Journal of Molecular Sciences 21, no. 2 (January 15, 2020): 555. http://dx.doi.org/10.3390/ijms21020555.

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Even 155 years after their first synthesis, Schiff bases continue to surprise inorganic chemists. Schiff-base ligands have played a major role in the development of modern coordination chemistry because of their relevance to a number of interdisciplinary research fields. The chemistry, properties and applications of transition metal and lanthanoid complexes with Schiff-base ligands are now quite mature. On the contrary, the coordination chemistry of Schiff bases with actinoid (5f-metal) ions is an emerging area, and impressive research discoveries have appeared in the last 10 years or so. The chemistry of actinoid ions continues to attract the intense interest of many inorganic groups around the world. Important scientific challenges are the understanding the basic chemistry associated with handling and recycling of nuclear materials; investigating the redox properties of these elements and the formation of complexes with unusual metal oxidation states; discovering materials for the recovery of trans-{UVIO2}2+ from the oceans; elucidating and manipulating actinoid-element multiple bonds; discovering methods to carry out multi-electron reactions; and improving the 5f-metal ions’ potential for activation of small molecules. The study of 5f-metal complexes with Schiff-base ligands is a currently “hot” topic for a variety of reasons, including issues of synthetic inorganic chemistry, metalosupramolecular chemistry, homogeneous catalysis, separation strategies for nuclear fuel processing and nuclear waste management, bioinorganic and environmental chemistry, materials chemistry and theoretical chemistry. This almost-comprehensive review, covers aspects of synthetic chemistry, reactivity and the properties of dinuclear and oligonuclear actinoid complexes based on Schiff-base ligands. Our work focuses on the significant advances that have occurred since 2000, with special attention on recent developments. The review is divided into eight sections (chapters). After an introductory section describing the organization of the scientific information, Sections 2 and 3 deal with general information about Schiff bases and their coordination chemistry, and the chemistry of actinoids, respectively. Section 4 highlights the relevance of Schiff bases to actinoid chemistry. Sections 5–7 are the “main menu” of the scientific meal of this review. The discussion is arranged according the actinoid (only for Np, Th and U are Schiff-base complexes known). Sections 5 and 7 are further arranged into parts according to the oxidation states of Np and U, respectively, because the coordination chemistry of these metals is very much dependent on their oxidation state. In Section 8, some concluding comments are presented and a brief prognosis for the future is attempted.

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32

Klein, Axel. "Bioinorganic Chemistry: A Practical Course. Von Nils Metzler-Nolte und Ulrich Schatzschneider." Angewandte Chemie 122, no. 13 (March 17, 2010): 2329–30. http://dx.doi.org/10.1002/ange.200906918.

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33

Nogueira, Thais Cristina Mendonça, Lucas dos Santos Cruz, Maria Cristina Lourenço, and Marcus Vinicius Nora de Souza. "Design, Synthesis and Anti-tuberculosis Activity of Hydrazones and N-acylhydrazones Containing Vitamin B6 and Different Heteroaromatic Nucleus." Letters in Drug Design & Discovery 16, no. 7 (June 27, 2019): 792–98. http://dx.doi.org/10.2174/1570180815666180627122055.

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Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal ,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5´-phosphate (PLP) is the most important and active form acting as a critical cofactor. These compounds are very useful in medicinal chemistry because of their structure and functionalities and are also used in bioinorganic chemistry as ligands for complexation with metals. Methods: In this study, a series of hydrazones 1a-g and N-acylhydrazones 2a-f containing vitamin B6 have been synthesized from commercial pyridoxal hydrochloride and the appropriate aromatic or heteroaromatic hydrazine or N-acylhydrazine. All synthesized compounds have been fully characterized and tested against Mycobacterium tuberculosis. Results: Among the N-acylhydrazones derivatives 2a-f, 2d (para- pyridine substituted Nacylhydrazone; MIC = 10.90 µM) exhibited the best activity. The ortho-pyridine derivative 2b exhibited intermediate activity (MIC = 87.32 µM), and the meta-pyridine derivative 2c was inactive. In case of the hydrazone series 1a-g, 7-chloroquinoxaline derivative 1f (MIC = 72.72 µM) showed the best result, indicating that the number of nitrogen and chlorine atoms in the radical moiety play an important role in the anti-tuberculosis activity of the quinoxaline derivatives (1f and 1g). Conclusion: The data reported herein indicates that the isoniazid derivative 2d (MIC = 10.90 µM) exhibited the best activity in the N-acylhydrazone series and; the quinoxaline nucleus derivative 1f (MIC = 72.72 µM) was the most active compound in the hydrazone series.

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34

Freisinger, Eva, and Roland K. O. Sigel. "The Bioinorganic Periodic Table." CHIMIA International Journal for Chemistry 73, no. 3 (March 27, 2019): 185–93. http://dx.doi.org/10.2533/chimia.2019.185.

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35

Johnstone, Timothy C., and Stephen J. Lippard. "Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]." JBIC Journal of Biological Inorganic Chemistry 19, no. 4-5 (February 11, 2014): 667–74. http://dx.doi.org/10.1007/s00775-014-1109-6.

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36

Tialiou, Alexia, Jiamin Chin, Bernhard K. Keppler, and Michael R. Reithofer. "Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment." Biomedicines 10, no. 6 (June 15, 2022): 1417. http://dx.doi.org/10.3390/biomedicines10061417.

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Since their first discovery, N-heterocyclic carbenes have had a significant impact on organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they are exceptionally well suited to stabilize Au(I) and Au(III) complexes in biological environments. Over the last decade, the development of rationally designed NHCAu(I/III) complexes to specifically target DNA has led to a new “gold rush” in bioinorganic chemistry. This review aims to summarize the latest advances of NHCAu(I/III) complexes that are able to interact with DNA. Furthermore, the latest advancements on acyclic diamino carbene gold complexes with anticancer activity are presented as these typically overlooked NHC alternatives offer great additional design possibilities in the toolbox of carbene-stabilized gold complexes for targeted therapy.

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37

Gupta, Rupal, Jenna Yehl, Mingyue Li, and Tatyana Polenova. "51V magic angle spinning NMR spectroscopy and quantum chemical calculations in vanadium bio-inorganic systems: current perspective." Canadian Journal of Chemistry 93, no. 9 (September 2015): 929–37. http://dx.doi.org/10.1139/cjc-2014-0557.

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In recent years, 51V magic angle spinning (MAS) NMR spectroscopy has been widely used to characterize vanadium centers in biology, biomimetic complexes, and inorganic compounds of medicinal and industrial relevance. It has been demonstrated that 51V NMR parameters are sensitive probes of the coordination geometry and chemical environment of the metal center, beyond the first coordination sphere. To establish the relationships between NMR parameters and structure of the vanadium centers, over the past decade a large series of coordination complexes have been analyzed by MAS NMR spectroscopy. It has been demonstrated that the interpretation of the NMR parameters requires the use of theoretical methods, such as density functional (DFT) theory, whereby the experimental NMR observables are linked to the electronic and structural properties of a molecule. DFT calculations have been successfully employed to not only predict NMR parameters but to also yield valuable information regarding the structure and function of various vanadium compounds. In this report, we review the current state of the field, and present a survey of bioinorganic vanadium complexes as well as vanadium-dependent haloperoxidases analyzed using 51V MAS NMR spectroscopy and DFT calculations, to illustrate the rich information content available from such a combined approach.

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38

Watly, Joanna, Aleksandra Hecel, Paulina Kolkowska, Henryk Kozlowski, and Magdalena Rowinska-Zyrek. "Poly-Xaa Sequences in Proteins - Biological Role and Interactions with Metal Ions: Chemical and Medical Aspects." Current Medicinal Chemistry 25, no. 1 (January 22, 2018): 22–48. http://dx.doi.org/10.2174/0929867324666170428104928.

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Background: The understanding of the bioinorganic and coordination chemistry of metalloproteins containing unusual poly-Xaa sequences, in which a single amino acid is repeated consecutively, is crucial for describing their metal binding-structure-function relationship, and therefore also crucial for understanding their medicinal potential. To the best of our knowledge, this is the first systematic review on metal complexes with polyXaa sequences. Methods: We performed a thorough search of high quality peer reviewed literature on poly-Xaa type of sequences in proteins, focusing on their biological importance and on their interactions with metal ions. Results: 228 papers were included in the review. More than 70% of them discussed the role of metal complexes with the studied types of sequences. In this work, we showed numerous medically important and chemically fascinating examples of possible ‘poly-Xaa' metal binding sequences. Conclusion: Poly-Xaa sequences, in which a single amino acid is repeated consecutively, are often not only tempting binding sites for metal ions, but very often, together with the bound metal, serve as structure determinants for entire proteins. This, in turn, can have consequences for the whole organism. Such sequences in bacterial metal chaperones can be a possible target for novel, antimicrobial therapeutics.

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39

Rabinovich, Mikhail L. "Concepts and Models in Bioinorganic Chemistry. By Heinz-Bernhard Kraatz and Niels Metzler-Nolte." Biotechnology Journal 3, no. 3 (March 2008): 420–21. http://dx.doi.org/10.1002/biot.200890031.

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40

Meggers, Eric. "Concepts and Models in Bioinorganic Chemistry. Edited by Heinz-Bernhard Kraatz and Nils Metzler-Nolte." ChemBioChem 8, no. 1 (January 2, 2007): 145. http://dx.doi.org/10.1002/cbic.200600395.

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41

Stoppa, Valentina, Edoardo Battistel, Marco Baron, Paolo Sgarbossa, Andrea Biffis, Gregorio Bottaro, Lidia Armelao, and Cristina Tubaro. "Dinuclear gold(I) Complexes with Bidentate NHC Ligands as Precursors for Alkynyl Complexes via Mechanochemistry." Molecules 27, no. 13 (July 5, 2022): 4317. http://dx.doi.org/10.3390/molecules27134317.

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The use of alkynyl gold(I) complexes covers different research fields, such as bioinorganic chemistry, catalysis, and material science, considering the luminescent properties of the complexes. Regarding this last application, we report here the synthesis of three novel dinuclear gold(I) complexes of the general formula [(diNHC)(Au-C≡CPh)2]: two Au-C≡CPh units are connected by a bridging di(N-heterocyclic carbene) ligand, which should favor the establishment of semi-supported aurophilic interactions. The complexes can be easily synthesized through mechanochemistry upon reacting the pristine dibromido complexes [(diNHC)(AuBr)2] with phenylacetylene and KOH. Interestingly, we were also able to isolate the monosubstituted complex [(diNHC)(Au-C≡CPh)(AuBr)]. The gold(I) species were fully characterized by multinuclear NMR spectroscopy and mass spectrometry. The emission properties were also evaluated, and the salient data are comparable to those of analogous compounds reported in the literature.

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42

Maurya, R. C., and S. Rajput. "Oxovanadium(IV) complexes of bioinorganic and medicinal relevance: synthesis, characterization, and 3D molecular modeling and analysis of some oxovanadium(IV) complexes involving O,O-donor environment." Journal of Molecular Structure 687, no. 1-3 (January 2004): 35–44. http://dx.doi.org/10.1016/j.molstruc.2003.08.023.

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43

Bartos, Adrian, and Joanna Sikora. "Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings." International Journal of Molecular Sciences 24, no. 4 (February 11, 2023): 3634. http://dx.doi.org/10.3390/ijms24043634.

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Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Complex organic structures with numerous aromatic moieties make up the majority of this list. This review fills a more overlooked niche by gathering, outlining and setting out conclusions regarding less prominent cases of ferroptosis induced by bioinorganic compounds and reported on within the last few years. The article contains a short summary of the application of bioinorganic chemicals based on gallium, several chalcogens, transition metals and elements known as human toxicants used for the purpose of evoking ferroptotic cell death in vitro or in vivo. These are used in the form of free ions, salts, chelates, gaseous and solid oxides or nanoparticles. Knowledge of how exactly these modulators promote or inhibit ferroptosis could be beneficial in the context of future therapies aimed against cancer or neurodegenerative diseases, respectively.

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44

Constable, Edwin C., Valérie Chaurin, Catherine E. Housecroft, and Amina Wirth. "In-Strand Metallated Nucleic Acids – Novel Bioinorganic Constructs." CHIMIA International Journal for Chemistry 59, no. 11 (November 1, 2005): 832–35. http://dx.doi.org/10.2533/000942905777675660.

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45

Shaik, Sason. "Computational Inorganic and Bioinorganic Chemistry. Herausgegeben von Edward I. Solomon, Robert A. Scott und R. Bruce King." Angewandte Chemie 122, no. 18 (April 19, 2010): 3177–79. http://dx.doi.org/10.1002/ange.201000436.

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46

Chiaverini, Lorenzo, Alessandro Pratesi, Damiano Cirri, Arianna Nardinocchi, Iogann Tolbatov, Alessandro Marrone, Mariagrazia Di Luca, Tiziano Marzo, and Diego La Mendola. "Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation." Molecules 27, no. 8 (April 16, 2022): 2578. http://dx.doi.org/10.3390/molecules27082578.

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Auranofin (AF, hereafter) is an orally administered chrysotherapeutic agent approved for the treatment of rheumatoid arthritis that is being repurposed for various indications including bacterial infections. Its likely mode of action involves the impairment of the TrxR system through the binding of the pharmacophoric cation [AuPEt3]+. Accordingly, a reliable strategy to expand the medicinal profile of AF is the replacement of the thiosugar moiety with different ligands. Herein, we aimed to prepare the AF analogue bearing the acetylcysteine ligand (AF-AcCys, hereafter) and characterize its anti-staphylococcal activity. Biological studies revealed that AF-AcCys retains an antibacterial effect superimposable with that of AF against Staphylococcus aureus, whereas it is about 20 times less effective against Staphylococcus epidermidis. Bioinorganic studies confirmed that upon incubation with human serum albumin, AF-AcCys, similarly to AF, induced protein metalation through the [AuPEt3]+ fragment. Additionally, AF-AcCys appeared capable of binding the dodecapeptide Ac-SGGDILQSGCUG-NH2, corresponding to the tryptic C-terminal fragment (488–499) of hTrxR. To shed light on the pharmacological differences between AF and AF-AcCys, we carried out a comparative experimental stability study and a theoretical estimation of bond dissociation energies, unveiling the higher strength of the Au–S bond in AF-AcCys. From the results, it emerged that the lower lipophilicity of AF-AcCys with respect to AF could be a key feature for its different antibacterial activity. The differences and similarities between AF and AF-AcCys are discussed, alongside the opportunities and consequences that chemical structure modifications imply.

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Jobelius, Hannah, Gabriella Bianchino, Franck Borel, Philippe Chaignon, and Myriam Seemann. "The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives." Molecules 27, no. 3 (January 21, 2022): 708. http://dx.doi.org/10.3390/molecules27030708.

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The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria. The absence of this pathway in mammalians makes it an interesting target for the discovery of novel anti-infectives. As last enzyme of this pathway, IspH is an oxygen sensitive [4Fe-4S] metalloenzyme that catalyzes 2H+/2e- reductions and a water elimination by involving non-conventional bioinorganic and bioorganometallic intermediates. After a detailed description of the discovery of the [4Fe-4S] cluster of IspH, this review focuses on the IspH mechanism discussing the results that have been obtained in the last decades using an approach combining chemistry, enzymology, crystallography, spectroscopies, and docking calculations. Considering the interesting druggability of this enzyme, a section about the inhibitors of IspH discovered up to now is reported as well. The presented results constitute a useful and rational help to inaugurate the design and development of new potential chemotherapeutics against pathogenic organisms.

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Maurya, R. C., and S. Rajput. "Neutral dioxovanadium(V) complexes of biomimetic hydrazones ONO donor ligands of bioinorganic and medicinal relevance: Synthesis via air oxidation of bis(acetylaceto-nato)oxovanadium(IV), characterization, biological activity and 3D molecular modeling." Journal of Molecular Structure 833, no. 1-3 (May 2007): 133–44. http://dx.doi.org/10.1016/j.molstruc.2006.09.022.

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Dimiza, Filitsa, Amalia Barmpa, Antonios Chronakis, Antonios G. Hatzidimitriou, Yiannis Sanakis, Athanasios N. Papadopoulos, and George Psomas. "Iron(III) Complexes with Non-Steroidal Anti-Inflammatory Drugs: Structure, Antioxidant and Anticholinergic Activity, and Interaction with Biomolecules." International Journal of Molecular Sciences 24, no. 7 (March 28, 2023): 6391. http://dx.doi.org/10.3390/ijms24076391.

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One the main research goals of bioinorganic chemists is the synthesis of novel coordination compounds possessing biological potency. Within this context, three novel iron(III) complexes with the non-steroidal anti-inflammatory drugs diflunisal and diclofenac in the presence or absence of the nitrogen donors 1,10-phenanthroline or pyridine were isolated and characterized by diverse techniques. The complexes were evaluated for their ability to scavenge in vitro free radicals such as hydroxyl, 1,1-diphenyl-2-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, revealing their selective potency towards hydroxyl radicals. The in vitro inhibitory activity of the complexes towards the enzymes acetylcholinesterase and butyrylcholinesterase was evaluated, and their potential to achieve neuroprotection appeared promising. The interaction of the complexes with calf-thymus DNA was examined in vitro, revealing their ability to intercalate in-between DNA nucleobases. The affinity of the complexes for serum albumins was evaluated in vitro and revealed their tight and reversible binding.

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Maurya, R. C., J. Chourasia, M. H. Martin, S. Roy, A. K. Sharma, and P. Vishwakarma. "Dioxomolybdenum(VI) chelates of bioinorganic, catalytic, and medicinal relevance: Studies on some cis-dioxomolybdenum(VI) complexes involving O, N-donor 4-oximino-2-pyrazoline-5-one derivatives." Arabian Journal of Chemistry 8, no. 3 (May 2015): 293–306. http://dx.doi.org/10.1016/j.arabjc.2011.01.010.

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