Relevant bibliographies by topics / Bioinks or Additive manufacturing

Academic literature on the topic 'Bioinks or Additive manufacturing'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Bioinks or Additive manufacturing"

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Zhang, Chun-Yang, Chao-Ping Fu, Xiong-Ya Li, Xiao-Chang Lu, Long-Ge Hu, Ranjith Kumar Kankala, Shi-Bin Wang, and Ai-Zheng Chen. "Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering." Molecules 27, no. 11 (May 26, 2022): 3442. http://dx.doi.org/10.3390/molecules27113442.

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Three-dimensional (3D) bioprinting is one of the most promising additive manufacturing technologies for fabricating various biomimetic architectures of tissues and organs. In this context, the bioink, a critical element for biofabrication, is a mixture of biomaterials and living cells used in 3D printing to create cell-laden structures. Recently, decellularized extracellular matrix (dECM)-based bioinks derived from natural tissues have garnered enormous attention from researchers due to their unique and complex biochemical properties. This review initially presents the details of the natural ECM and its role in cell growth and metabolism. Further, we briefly emphasize the commonly used decellularization treatment procedures and subsequent evaluations for the quality control of the dECM. In addition, we summarize some of the common bioink preparation strategies, the 3D bioprinting approaches, and the applicability of 3D-printed dECM bioinks to tissue engineering. Finally, we present some of the challenges in this field and the prospects for future development.
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Theus, Andrea S., Liqun Ning, Boeun Hwang, Carmen Gil, Shuai Chen, Allison Wombwell, Riya Mehta, and Vahid Serpooshan. "Bioprintability: Physiomechanical and Biological Requirements of Materials for 3D Bioprinting Processes." Polymers 12, no. 10 (October 1, 2020): 2262. http://dx.doi.org/10.3390/polym12102262.

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Three-dimensional (3D) bioprinting is an additive manufacturing process that utilizes various biomaterials that either contain or interact with living cells and biological systems with the goal of fabricating functional tissue or organ mimics, which will be referred to as bioinks. These bioinks are typically hydrogel-based hybrid systems with many specific features and requirements. The characterizing and fine tuning of bioink properties before, during, and after printing are therefore essential in developing reproducible and stable bioprinted constructs. To date, myriad computational methods, mechanical testing, and rheological evaluations have been used to predict, measure, and optimize bioinks properties and their printability, but none are properly standardized. There is a lack of robust universal guidelines in the field for the evaluation and quantification of bioprintability. In this review, we introduced the concept of bioprintability and discussed the significant roles of various physiomechanical and biological processes in bioprinting fidelity. Furthermore, different quantitative and qualitative methodologies used to assess bioprintability will be reviewed, with a focus on the processes related to pre, during, and post printing. Establishing fully characterized, functional bioink solutions would be a big step towards the effective clinical applications of bioprinted products.
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Jose, Rod R., Maria J. Rodriguez, Thomas A. Dixon, Fiorenzo Omenetto, and David L. Kaplan. "Evolution of Bioinks and Additive Manufacturing Technologies for 3D Bioprinting." ACS Biomaterials Science & Engineering 2, no. 10 (April 7, 2016): 1662–78. http://dx.doi.org/10.1021/acsbiomaterials.6b00088.

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Ahangar, Pouyan, Megan E. Cooke, Michael H. Weber, and Derek H. Rosenzweig. "Current Biomedical Applications of 3D Printing and Additive Manufacturing." Applied Sciences 9, no. 8 (April 25, 2019): 1713. http://dx.doi.org/10.3390/app9081713.

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Additive manufacturing (AM) has emerged over the past four decades as a cost-effective, on-demand modality for fabrication of geometrically complex objects. The ability to design and print virtually any object shape using a diverse array of materials, such as metals, polymers, ceramics and bioinks, has allowed for the adoption of this technology for biomedical applications in both research and clinical settings. Current advancements in tissue engineering and regeneration, therapeutic delivery, medical device fabrication and operative management planning ensure that AM will continue to play an increasingly important role in the future of healthcare. In this review, we outline current biomedical applications of common AM techniques and materials.
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Temirel, Mikail, Sajjad Rahmani Dabbagh, and Savas Tasoglu. "Shape Fidelity Evaluation of Alginate-Based Hydrogels through Extrusion-Based Bioprinting." Journal of Functional Biomaterials 13, no. 4 (November 7, 2022): 225. http://dx.doi.org/10.3390/jfb13040225.

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Extrusion-based 3D bioprinting is a promising technique for fabricating multi-layered, complex biostructures, as it enables multi-material dispersion of bioinks with a straightforward procedure (particularly for users with limited additive manufacturing skills). Nonetheless, this method faces challenges in retaining the shape fidelity of the 3D-bioprinted structure, i.e., the collapse of filament (bioink) due to gravity and/or spreading of the bioink owing to the low viscosity, ultimately complicating the fabrication of multi-layered designs that can maintain the desired pore structure. While low viscosity is required to ensure a continuous flow of material (without clogging), a bioink should be viscous enough to retain its shape post-printing, highlighting the importance of bioink properties optimization. Here, two quantitative analyses are performed to evaluate shape fidelity. First, the filament collapse deformation is evaluated by printing different concentrations of alginate and its crosslinker (calcium chloride) by a co-axial nozzle over a platform to observe the overhanging deformation over time at two different ambient temperatures. In addition, a mathematical model is developed to estimate Young’s modulus and filament collapse over time. Second, the printability of alginate is improved by optimizing gelatin concentrations and analyzing the pore size area. In addition, the biocompatibility of proposed bioinks is evaluated with a cell viability test. The proposed bioink (3% w/v gelatin in 4% alginate) yielded a 98% normalized pore number (high shape fidelity) while maintaining >90% cell viability five days after being bioprinted. Integration of quantitative analysis/simulations and 3D printing facilitate the determination of the optimum composition and concentration of different elements of a bioink to prevent filament collapse or bioink spreading (post-printing), ultimately resulting in high shape fidelity (i.e., retaining the shape) and printing quality.
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Ojeda, Edilberto, África García-Barrientos, Nagore Martínez de Cestafe, José María Alonso, Raúl Pérez-González, and Virginia Sáez-Martínez. "Nanometric Hydroxyapatite Particles as Active Ingredient for Bioinks: A Review." Macromol 2, no. 1 (January 4, 2022): 20–29. http://dx.doi.org/10.3390/macromol2010002.

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Additive manufacturing (AM), frequently cited as three-dimensional (3D) printing, is a relatively new manufacturing technique for biofabrication, also called 3D manufacture with biomaterials and cells. Recent advances in this field will facilitate further improvement of personalized healthcare solutions. In this regard, tailoring several healthcare products such as implants, prosthetics, and in vitro models, would have been extraordinarily arduous beyond these technologies. Three-dimensional-printed structures with a multiscale porosity are very interesting manufacturing processes in order to boost the capability of composite scaffolds to generate bone tissue. The use of biomimetic hydroxyapatite as the main active ingredient for bioinks is a helpful approach to obtain these advanced materials. Thus, 3D-printed biomimetic composite designs may produce supplementary biological and physical benefits. Three-dimensional bioprinting may turn to be a bright solution for regeneration of bone tissue as it enables a proper spatio-temporal organization of cells in scaffolds. Different types of bioprinting technologies and essential parameters which rule the applicability of bioinks are discussed in this review. Special focus is made on hydroxyapatite as an active ingredient for bioinks design. The goal of such bioinks is to reduce the constraints of commonly applied treatments by enhancing osteoinduction and osteoconduction, which seems to be exceptionally promising for bone regeneration.
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Szychlinska, Marta Anna, Fabio Bucchieri, Alberto Fucarino, Alfredo Ronca, and Ugo D’Amora. "Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources." Journal of Functional Biomaterials 13, no. 3 (August 12, 2022): 118. http://dx.doi.org/10.3390/jfb13030118.

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In regenerative medicine and tissue engineering, the possibility to: (I) customize the shape and size of scaffolds, (II) develop highly mimicked tissues with a precise digital control, (III) manufacture complex structures and (IV) reduce the wastes related to the production process, are the main advantages of additive manufacturing technologies such as three-dimensional (3D) bioprinting. Specifically, this technique, which uses suitable hydrogel-based bioinks, enriched with cells and/or growth factors, has received significant consideration, especially in cartilage tissue engineering (CTE). In this field of interest, it may allow mimicking the complex native zonal hyaline cartilage organization by further enhancing its biological cues. However, there are still some limitations that need to be overcome before 3D bioprinting may be globally used for scaffolds’ development and their clinical translation. One of them is represented by the poor availability of appropriate, biocompatible and eco-friendly biomaterials, which should present a series of specific requirements to be used and transformed into a proper bioink for CTE. In this scenario, considering that, nowadays, the environmental decline is of the highest concerns worldwide, exploring naturally-derived hydrogels has attracted outstanding attention throughout the scientific community. For this reason, a comprehensive review of the naturally-derived hydrogels, commonly employed as bioinks in CTE, was carried out. In particular, the current state of art regarding eco-friendly and natural bioinks’ development for CTE was explored. Overall, this paper gives an overview of 3D bioprinting for CTE to guide future research towards the development of more reliable, customized, eco-friendly and innovative strategies for CTE.
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Rameshwar, Pranela, Vibha Harindra Savanur, Jean-Pierre Etchegaray, and Murat Guvendiren. "3D bioprinting as a designer organoid to assess pathological processes in translational medicine." Journal of 3D Printing in Medicine 6, no. 1 (March 2022): 37–46. http://dx.doi.org/10.2217/3dp-2021-0006.

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3D bioprinting is an additive manufacturing method, formulated with cells printed in bioinks of basic matrix such as hydrogels. Bioinks are relevant to precision medicine mainly due to recapitulation of tissue organoids with broad application. 3D bioprinting can address the issue of increased cost in drug development with overall benefit in healthcare. Despite research, solid and hematological cancer remain a clinical problem. Existing models such as patient-derived xenografts and organoids, although beneficial, have limitations. This perspective discusses 3D bioprinting in key clinical issues to hasten treatment to patients. The diseases addressed are aging, cancer metastasis, cancer dormancy and drug screening. The perspective also discusses the application for other diseases and the future for 3D bioprinting in medicine.
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Yang, Haowei, Kai-Hung Yang, Roger J. Narayan, and Shaohua Ma. "Laser-based bioprinting for multilayer cell patterning in tissue engineering and cancer research." Essays in Biochemistry 65, no. 3 (August 2021): 409–16. http://dx.doi.org/10.1042/ebc20200093.

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Abstract 3D printing, or additive manufacturing, is a process for patterning functional materials based on the digital 3D model. A bioink that contains cells, growth factors, and biomaterials are utilized for assisting cells to develop into tissues and organs. As a promising technique in regenerative medicine, many kinds of bioprinting platforms have been utilized, including extrusion-based bioprinting, inkjet bioprinting, and laser-based bioprinting. Laser-based bioprinting, a kind of bioprinting technology using the laser as the energy source, has advantages over other methods. Compared with inkjet bioprinting and extrusion-based bioprinting, laser-based bioprinting is nozzle-free, which makes it a valid tool that can adapt to the viscosity of the bioink; the cell viability is also improved because of elimination of nozzle, which could cause cell damage when the bioinks flow through a nozzle. Accurate tuning of the laser source and bioink may provide a higher resolution for reconstruction of tissue that may be transplanted used as an in vitro disease model. Here, we introduce the mechanism of this technology and the essential factors in the process of laser-based bioprinting. Then, the most potential applications are listed, including tissue engineering and cancer models. Finally, we present the challenges and opportunities faced by laser-based bioprinting.
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Albrecht, Franziska B., Freia F. Schmidt, Ann-Cathrin Volz, and Petra J. Kluger. "Bioprinting of 3D Adipose Tissue Models Using a GelMA-Bioink with Human Mature Adipocytes or Human Adipose-Derived Stem Cells." Gels 8, no. 10 (September 25, 2022): 611. http://dx.doi.org/10.3390/gels8100611.

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Adipose tissue is related to the development and manifestation of multiple diseases, demonstrating the importance of suitable in vitro models for research purposes. In this study, adipose tissue lobuli were explanted, cultured, and used as an adipose tissue control to evaluate in vitro generated adipose tissue models. During culture, lobule exhibited a stable weight, lactate dehydrogenase, and glycerol release over 15 days. For building up in vitro adipose tissue models, we adapted the biomaterial gelatin methacryloyl (GelMA) composition and handling to homogeneously mix and bioprint human primary mature adipocytes (MA) and adipose-derived stem cells (ASCs), respectively. Accelerated cooling of the bioink turned out to be essential for the homogeneous distribution of lipid-filled MAs in the hydrogel. Last, we compared manual and bioprinted GelMA hydrogels with MA or ASCs and the explanted lobules to evaluate the impact of the printing process and rate the models concerning the physiological reference. The viability analyses demonstrated no significant difference between the groups due to additive manufacturing. The staining of intracellular lipids and perilipin A suggest that GelMA is well suited for ASCs and MA. Therefore, we successfully constructed physiological in vitro models by bioprinting MA-containing GelMA bioinks.
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Dissertations / Theses on the topic "Bioinks or Additive manufacturing"

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Minck, Justin Stewart. "DEVELOPING A LOW COST BIOLOGICAL ADDITIVE MANUFACTURING SYSTEM FOR FABRICATING GEL EMBEDDED CELLULAR CONSTRUCTS." CSUSB ScholarWorks, 2019. https://scholarworks.lib.csusb.edu/etd/844.

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Organ transplantation has made great progress since the first successful kidney transplant in 1953 and now more than one million tissue transplants are performed in the United States every year (www.organdonor.gov/statistics-stories, 2015). However, the hope and success of organ transplants are often overshadowed by their reputation as being notoriously difficult to procure because of donor-recipient matching and availability. In addition, those that are fortunate enough to receive a transplant are burdened with a lifetime of immunosuppressants. The field of regenerative medicine is currently making exceptional progress toward making it possible for a patient to be their own donor. Cells from a patient can be collected, reprogrammed into stem cells, and then differentiated into specific cell types. This technology combined with recent advances in 3D printing provides a unique opportunity. Cells can now be accurately deposited with computerized precision allowing tissue engineering from the inside out (Gill, 2016). However, more work needs to be done as these techniques have yet to be perfected. Bioprinters can cost hundreds of thousands of dollars, and the bioink they consume costs thousands per liter. The resulting cost in development of protocols required for effective tissue printing can thus be cost-prohibitive, limiting the research to labs which can afford this exorbitant cost and in turn slowing the progress made in the eventual creation of patient derived stem cell engineered organs. The objective of my research is to develop a simple and low-cost introductory system for biological additive manufacturing (Otherwise known as 3D bioprinting). To create an easily accessible and cost-effective system several design constraints were implemented. First, the system had to use mechanical components that could be purchased “off-the-shelf” from commonly available retailers. Second, any mechanical components involved had to be easily sterilizable, modifiable, and compatible with open-source software. Third, any customized components had to be fabricated using only 3D printing and basic tools (i.e. saw, screwdriver, and wrench). Fourth, the system and any expendable materials should be financially available to underfunded school labs, in addition to being sterilizable, biocompatible, customizable, and biodegradable. Finally, all hardware and expendables had to be simple enough as to be operated by high school science students.
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Hintz, Madeline L. "Optimising breast implant geometry using 3-dimensional imaging." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/115013/1/115013_7535198_madeline_hintz_thesis.pdf.

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Three-dimensional printing has broad potential for the medical landscape as demonstrated in the two projects that comprise this thesis. Project one encompasses three-dimensional scanning of healthy volunteers to create equations that enable prediction of breast dimensions and volume directly from torso landmarks and measurements. Future development may streamline the creation of custom computer modelled breast implant scaffolds for three-dimensional printing and improve aesthetic outcomes. Project two outlines the creation, bioprinting and assessment of a new biological ink with components generally found in breast tumours. These techniques may be used in the future to create customised models for drug testing.
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Keil, Heinz Simon. "Quo vadis "Additive Manufacturing"." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-214719.

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Aus der Einführung: "Stehen wir am Rande einer bio-nanotechnologischen getriebenen Revolution, die unsere Art zu leben, zu arbeiten und miteinander umzugehen grundlegend verändern wird? Welchem gesellschaftspolitischen, wirtschaftlichen und technologischen Wandel haben wir uns zu stellen? Langfristige Entwicklungszyklen (Kondratieff, Schumpeter) führen zur nachhaltigen Weiterentwicklung der Zivilisation. Mittelfristige Entwicklungen wie die Trends Globalisierung, Urbanisierung, Digitalisierung (Miniaturisierung) und Humanisierung (Individualisierung), die immer stärker unser Umfeld und Handeln beeinflussen führen zu ganzheitlichen, weltumspannenden Grundtendenzen der gesellschaftlichen Weiterentwicklung. Die technologischen "Enabler" Computing, Biotechnology, Artifical Intelligence, Robotik, Nanotechnology, Additive Manufacturing und Design Thinking wirken beschleunigend auf die gesellschaftlichen Entwicklungen ein. Die technologischen Möglichkeiten beschleunigen sowohl gesellschaftspolitische Zyklen und zivilisatorische Anpassungen. Durch rasanten technologischen, wissenschaftlichen Fortschritt, zunehmende Globalisierungswirkungen, beschleunigte Urbanisierung und aber auch politischer Interferenzen sind die Veränderungsparameter eines dynamischen Geschäftsumfelds immer schnellere Transformationen ausgesetzt. Alle diese Richtungen zeigen das unsere gesellschaftliche Entwicklung inzwischen stark durch die Technik getrieben ist. Ob dies auch heißt, dass wir den Punkt der Singularität (Kurzweil) absehbar erreichen ist dennoch noch offen. ..."
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Leirvåg, Roar Nelissen. "Additive Manufacturing for Large Products." Thesis, Norges Teknisk-Naturvitenskaplige Universitet, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-20870.

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This thesis researches the possibility and feasibility of applying additive manufacturing technology in the manufacturing of propellers. The thesis concerns the production at the foundry Oshaug Metall AS. Their products consist of propellers and other large products cast in Nickel-Aluminium Bronze. This report looks at three approaches and applications for additive manufacturing at the foundry. These are additively manufactured pattern, sand mold and end metal parts. The available \emph{State of the Art} systems for the three approaches are listed and the systems suitability is discussed. The systems that meet the stated criteria are selected and further discussion on the advantages and disadvantages of the additive manufacturing approach to the application are carried out for the three respective applications. An experiment was carried out on a scaled propeller blade to measure the geometrical accuracy and surface quality of a 3D-printed pattern. The report is concluded with the conclusion to the stated task and recommendations for further work.
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Jun, Sung Yun. "Additive manufacturing for antenna applications." Thesis, University of Kent, 2018. https://kar.kent.ac.uk/68833/.

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This thesis presents methods to make use of additive manufacturing (AM) or 3D printing (3DP) technology for the fabrication of antenna and electromagnetic (EM) structures. A variety of 3DP techniques based on filament, resin, powder and nano-particle inks are applied for the development and fabrication of antennas. Fully and partially metallised 3D printed EM structures are investigated for operation at mainly microwave frequency bands. First, 3D Sierpinski fractal antennas are fabricated using binder jetting printing technique, which is an AM metal powder bed process. It follows with the introduction of a new concept of sensing liquids using and non-planer electromagnetic band gap (EBG) structure is investigated. Such structure can be fabricated with inexpensive fuse filament fabrication (FFF) in combination with conductive paint. As a third method, inkjet printing technology is used for the fabrication of antennas for origami paper applications. The work investigates the feasibility of fabricating foldable antennas for disposable paper drones using low-cost inkjet printing equipment. It then explores the applicability of inkjet printing on a 3D printing substrate through the fabrication of a circularly polarised patch antenna which combines stereolithography (SLA) and inkjet printing technology, both of which use inexpensive machines. Finally, a variety of AM techniques are applied and compared for the production of a diversity WLAN antenna system for customized wrist-worn application.
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Ranjan, Rajit. "Design for Manufacturing and Topology Optimization in Additive Manufacturing." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439307951.

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Lebherz, Matthias, and Jonathan Hartmann. "Commercializing Additive Manufacturing Technologies : A Business Model Innovation approach to shift from Traditional to Additive Manufacturing." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-36132.

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Additive Manufacturing is a fast-developing technology that is considered to be a game changer in the manufacturing industry. However, a technological innovation itself has no single objective value for a company. Indeed, it is widely acknowledged that the key aspect of a successful commercialization of a technological innovation is the linkage of the technology and the business model. Based on a qualitative study, which presents how companies have to develop their business model to commercialize AM, we conducted interviews with two Swedish small and medium-sized enterprises, which plan to invest in Additive Manufacturing. These two companies are HGF, a manufacturer of thermoplastic elastomers and rubber products, and Tylö, a manufacturer of heaters, steam generators, saunas, steam showers, and infrared saunas. In our analysis, we decided to analyse the cases successively, according to the nine building blocks of the Business Model Canvas. Firstly, we conducted a within-case analysis to analyse each case isolated from each other, and secondly a cross-case analysis to find possible nexuses, relations or, contrasts. The chapter conclusion provides an overall discussion of the most important findings emerging from the analysis with regard to the required changes within the current business model to capture value from the technology. We could find some disparities for two building blocks (channels and revenue streams). Thus, this implies that there is no universal approach to develop the business model to introduce Additive Manufacturing. Nevertheless, most of the required adjustments show accordance. While three building blocks turned out to remain largely the same (key partnerships, cost structure, and customer segments), four building blocks require important changes (key activities, key resources, value propositions, and customer relationships. The most important implications for those building blocks are presented in the following: Key activities: Upgrade product development Key resources: Establish additional production facilities (3D-printers, etc.) Gather new knowledge about AM Value propositions: Offer customized products Customer relationships: Closer relationship with the (end) customer  Enhance customer co-creation
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Khan, Imran. "Electrically conductive nanocomposites for additive manufacturing." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670587.

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La tesi se centra en l’ús de nanocomposites conductors elèctricament en la fabricació d’additius. En aquest escenari, dos tipus de nanocomposites estan preparats per utilitzar-los com a matèria primera per a la impressió de nanocomposites conductors elèctricament amb dos tipus diferents de matrius; (1) un polímer termoplàstic i (2) una resina termoestable. Els nanotubs de carboni es van utilitzar com a partícules conductores elèctriques de nanoestructura. Aquestes nanoestructures formen xarxes complexes en una matriu de polímer de manera que el material de la matriu es transforma d’un material aïllant en un material conductor elèctricament. La policaprolactona és un polímer semicristal·lí i es considera material matricial adequat entre la classe de polímers termoplàstics, ja que ofereix unes excel·lents característiques reològiques, de flux i elàstiques. Les cadenes es van imprimir mitjançant una extrusora bio i es va mesurar la conductivitat elèctrica en aquestes cadenes amb l’efecte de la deformació uniaxial. La microstructura canvia sota l’efecte de la deformació uniaxial, provocant una alteració de l’orientació de nanotubs de carboni a la matriu de policaprolactona. Com a conseqüència de la reordenació de nanotubs, les vies conductores es desorganitzen o s’organitzen que poden augmentar o disminuir la conductivitat elèctrica en els nanocomposites. Les radiacions del sincrotró s’utilitzen per sondar aquests canvis en la microestructura. Es van preparar diferents composicions mitjançant nanotubs de carboni i es van estudiar les mostres impreses en termes de conductivitat elèctrica i microestructura mitjançant radiacions de sincrotró. A partir de l’anàlisi, es proposa un model que pugui predir la conductivitat elèctrica sota l’efecte de la deformació uniaxial. En termes de polímers termoestables, s’introdueix un sistema senzill per a la impressió de nanocomposites basats en polímers termoset. En un dels capítols es proporciona un detall complet del sistema d’impressió i de la tinta nanocomposita. Es va preparar tinta de nanocomposites basada en epoxi per contenir nanotubs de carboni com a partícules de farciment amb una petita porció de polímer termoplàstic, policaprolactona. Les mostres impreses estan subjectes al biaix extern que indiquen que són conductores elèctricament. Es van preparar diferents composicions utilitzant resina glicidil bisfenol-A epoxi, trietilenetetramina, policaprolactona, nanotubs de carboni i es destaquen els problemes per obtenir una qualitat d’impressió adequada. Les mostres impreses es van estudiar en termes de conductivitat elèctrica estudiant la conductivitat elèctrica de corrent altern i directe. El sistema material s’explora quant al nivell de reticulació, l’estructura i la morfologia i el comportament tèrmic. Es presenta un model per als nanocomposites mitjançant dades d’impedància obtingudes mitjançant l’espectroscòpia dielèctrica de banda ampla. La impressora s’utilitzarà en un futur per imprimir dispositius funcionals a petita escala, inclosos dispositius d’emmagatzematge d’energia, p. bateries d’estat sòlid, supercondensadors i plaques d’elèctrodes per a aquest tipus de dispositius.
La fabricación aditiva (AM) es un proceso de fabricación de capas sucesivas de material para construir un objeto sólido tridimensional a partir de un modelo digital, a diferencia de las metodologías de fabricación sustractiva. AM ofrece la libertad de diseñar e innovar un producto para que se puedan obtener y revisar piezas complejas si es necesario, en un tiempo reducido en comparación con las tecnologías de fabricación tradicionales. En términos de su utilización total y generalizada, la tecnología tiene aplicaciones limitadas. Por motivos similares, la nanotecnología se considera la fuerza impulsora detrás de una nueva revolución industrial. Tiene la capacidad de incorporar funcionalidades específicas, que se producen debido a la escala nanométrica, a las partes deseadas para dispositivos funcionales como electrodos para dispositivos de almacenamiento de energía. La tesis se centra en el uso de nanocompuestos conductores de electricidad en la fabricación aditiva. En este escenario, dos tipos de nanocompuestos están preparados para usar como materia prima para la impresión de nanocompuestos conductores de electricidad que emplean dos tipos diferentes de material matricial; (1) un polímero termoplástico y (2) una resina termoestable. Los nanotubos de carbono se usaron como partículas de nanoestructura eléctricamente conductoras. Estas nanoestructuras forman redes complejas en una matriz polimérica de manera que el material de la matriz se transforma de un material aislante en un material eléctricamente conductor. La policaprolactona es un polímero semicristalino y se considera un material matriz adecuado entre la clase de polímeros termoplásticos, ya que ofrece excelentes características reológicas, de flujo y elásticas. Los hilos se imprimieron usando una extrusora biológica y se midió la conductividad eléctrica en estos hilos bajo el efecto de la deformación uniaxial. La microestructura cambia bajo el efecto de una deformación uniaxial que conduce a alterar la orientación de los nanotubos de carbono en la matriz de policaprolactona. Como consecuencia de la realineación de los nanotubos, las vías conductoras interrumpen u organizan, lo que puede aumentar o disminuir la conductividad eléctrica en los nanocompuestos. Las radiaciones de sincrotrón se utilizan para sondear tales cambios en la microestructura. Se prepararon diferentes composiciones usando nanotubos de carbono y las muestras impresas se estudiaron en términos de conductividad eléctrica y microestructura usando radiaciones sincrotrónicas. Basado en el análisis, se propone un modelo que puede predecir la conductividad eléctrica bajo el efecto de la deformación uniaxial. En términos de polímeros termoestables, se introduce un sistema simple para la impresión de nanocompuestos termoestables a base de polímeros. El detalle completo del sistema de impresión y la tinta de nanocompuestos se proporciona en uno de los capítulos. La tinta de nanocompuesto a base de epoxi se preparó para contener nanotubos de carbono como partículas de relleno con una pequeña porción de polímero termoplástico, policaprolactona. Las muestras impresas están sujetas al sesgo externo que indica que son eléctricamente conductoras. Se prepararon diferentes composiciones usando resina epoxi de glicidil bisfenol-A, trietilentetramina, policaprolactona, nanotubos de carbono y se resaltan los problemas para adquirir la calidad de impresión adecuada. Las muestras impresas se estudiaron en términos de conductividad eléctrica, estudiando la conductividad eléctrica de corriente alterna y continua. El sistema de materiales se explora en términos del nivel de reticulación, estructura y morfología y comportamiento térmico. Se presenta un modelo para los nanocompuestos utilizando datos de impedancia obtenidos mediante espectroscopía dieléctrica de banda ancha. La impresora se utilizará en el futuro para imprimir dispositivos funcionales a pequeña escala, incluidos dispositivos de almacenamiento de energía.
Additive manufacturing is a process of making successive layers of material to build a three-dimensional solid object from a digital model, as opposed to subtractive manufacturing methodologies. This technology offers the freedom to design and innovation of a product so that complex parts can be obtained and revise if needed, within a small time as compared to traditional manufacturing technologies. In terms of its full utilization and widespread, the technology has limited applications. On similar grounds, nanotechnology is considered as the driving force behind a new industrial revolution. It has the ability to incorporate specific functionalities, occur due to the nanometric scale, to desired parts that offer freedom to design functional devices like electrodes for energy storage devices. The thesis is focusing on the use of electrically conductive nanocomposites into additive manufacturing. In this scenario, two types of nanocomposites are prepared to use as raw material for printing of electrically conductive nanocomposites employing two different types of matrix material; (1) a thermoplastic polymer and (2) a thermoset resin. Carbon nanotubes were used as electrically conductive nanostructure particles. These nanostructures form complex networks into a polymer matrix such that the matrix material transforms from an insulative material into an electrically conductive material. Polycaprolactone is a semicrystalline polymer and it is considered suitable matrix material amongst the class of thermoplastic polymers as it offers excellent rheological, flow and the elastic characteristics. Strands were printed using a bio extruder and electrical conductivity was measured in these strands under the effect of uniaxial deformation. The microstructure changes under the effect of uniaxial deformation leading to alter the orientation of carbon nanotubes in the polycaprolactone matrix. As a consequence of realignment of nanotubes, conductive pathways either disrupt or organize which can increase or decrease an electrical conductivity in the nanocomposites. Synchrotron radiations are used to probe such changes in the microstructure. Two different compositions were prepared using carbon nanotubes and the printed samples are studied in terms of electrical conductivity and microstructure using synchrotron radiations. Based on the analysis, a model is proposed that can predict the orientation of carbon nanotubes under the effect of uniaxial deformation. In terms of thermoset polymers, a simple system is introduced for the printing of thermoset polymer (epoxy) based nanocomposites. Complete detail of the printing system is provided in one of the chapters. Epoxy-based nanocomposite ink was prepared to contain carbon nanotubes as filler particles with a small portion of thermoplastic polymer, polycaprolactone. The printed samples are subject to the external bias which indicate that these are electrically conductive. A complete methodology was provided for the preparation of nanocomposite ink. Different compositions were prepared using glycidyl bisphenol-A epoxy resin, triethylenetetramine, polycaprolactone, carbon nanotubes and issues are highlighted to acquire appropriate print quality. The printed samples were studied in terms of electrical conductivity studying alternating and direct current electrical conductivity. The material system is explored in terms of the level of crosslinking, structure and morphology and thermal behaviour. A model is presented for the nanocomposites using impedance data obtained through broadband dielectric spectroscopy. The printer will be used in future to print small scale functional devices including energy storage devices e.g. solid-state batteries, supercapacitors and electrode plates for such kind of devices.
Universitat Autònoma de Barcelona. Programa de Doctorat en Ciència de Materials
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Nopparat, Nanond, and Babak Kianian. "Resource Consumption of Additive Manufacturing Technology." Thesis, Blekinge Tekniska Högskola, Sektionen för ingenjörsvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3919.

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The degradation of natural resources as a result of consumption to support the economic growth of humans society represents one of the greatest sustainability challenges. In order to allow economic growth to continue in a sustainable way, it has to be decoupled from the consumption and destruction of natural resources. This thesis focuses on an innovative manufacturing technology called additive manufacturing (AM) and its potential to become a more efficient and cleaner manufacturing alternative. The thesis also investigates the benefits of accessing the technology through the result-oriented Product-Service Systems (PSS) approach. The outcome of the study is the quantification of raw materials and energy consumption. The scope of study is the application of AM in the scale model kit industry. The methods used are the life cycle inventory study and the system dynamics modeling. The result shows that AM has higher efficiency in terms of raw material usage, however it also has higher energy consumption in comparison to the more traditional manufacturing techniques. The result-oriented PSS approach is shown to be able to reduce the amount of manufacturing equipment needed, thus reducing the energy and raw materials used to produce the equipment, but does not completely decouple economic growth from the consumption of natural resources.
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McLearen, Luke J. "Additive manufacturing in the Marine Corps." Thesis, Monterey, California: Naval Postgraduate School, 2015. http://hdl.handle.net/10945/45903.

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Approved for public release; distribution is unlimited
As the Marine Corps continues to conduct small-unit distributed operations, the strain on its logistics intensifies. The Marine Corps must search for a solution to increase the efficiency and responsiveness of its logistics. One solution is using additive manufacturing, commonly referred to as 3D printing. This thesis answers the question of how additive manufacturing can improve the effectiveness of Marine Corps logistics. In order to answer the question, beneficial process(es), application(s), and level of integration are determined through a comparative analysis of current and future 3D-printing processes, examination of several civilian and military examples, and examination of the impact across current doctrine, organization, training, material, leadership, personnel, and facilities. Several issues should be addressed prior to the Marine Corps fully integrating 3D printers, such as the lack of certification and qualification standards, unreliable end product results, and determining ownership of intellectual property. When these issues are properly mitigated, the Marine Corps should procure printers for the purpose of manufacturing repair parts, tools, and other support aids. Marine Expeditionary Units should be the first units to receive the printers. If the printers are integrated properly, they could assist logisticians in supporting Marines conducting distributed operations throughout the battlefield.
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Books on the topic "Bioinks or Additive manufacturing"

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Killi, Steinar, ed. Additive Manufacturing. 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742: CRC Press, 2017. http://dx.doi.org/10.1201/9781315196589.

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Srivastava, Manu, Sandeep Rathee, Sachin Maheshwari, and T. K. Kundra. Additive Manufacturing. Boca Raton, FL : CRC Press/Taylor & Francis Group, 2019.: CRC Press, 2019. http://dx.doi.org/10.1201/9781351049382.

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Zhou, Kun, ed. Additive Manufacturing. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-04721-3.

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Pandey, Pulak Mohan, Nishant K. Singh, and Yashvir Singh. Additive Manufacturing. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003258391.

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Understanding additive manufacturing. Cincinnati, Ohio: Hanser Publications, 2011.

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Gebhardt, Andreas. Understanding Additive Manufacturing. München: Carl Hanser Verlag GmbH & Co. KG, 2011. http://dx.doi.org/10.3139/9783446431621.

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Kumar, Sanjay. Additive Manufacturing Solutions. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80783-2.

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Morar, Dominik. Additive Manufacturing (AM). Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-37153-1.

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Kumar, Sanjay. Additive Manufacturing Classification. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-14220-8.

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Gibson, Ian, David Rosen, Brent Stucker, and Mahyar Khorasani. Additive Manufacturing Technologies. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-56127-7.

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Book chapters on the topic "Bioinks or Additive manufacturing"

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Nulty, Jessica, Rossana Schipani, Ross Burdis, and Daniel J. Kelly. "Bioinks and Their Applications in Tissue Engineering." In Polymer-Based Additive Manufacturing, 187–218. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24532-0_9.

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Gebhardt, Andreas. "Direct Manufacturing – Rapid Manufacturing." In Additive Fertigungsverfahren, 457–526. München: Carl Hanser Verlag GmbH & Co. KG, 2016. http://dx.doi.org/10.3139/9783446445390.006.

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Gebhardt, Andreas, and Jan-Steffen Hötter. "Direct Manufacturing: Rapid Manufacturing." In Additive Manufacturing, 395–450. München: Carl Hanser Verlag GmbH & Co. KG, 2016. http://dx.doi.org/10.3139/9781569905838.006.

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Herrera Ramirez, Jose Martin, Raul Perez Bustamante, Cesar Augusto Isaza Merino, and Ana Maria Arizmendi Morquecho. "Additive Manufacturing." In Unconventional Techniques for the Production of Light Alloys and Composites, 89–102. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-48122-3_6.

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Rietzel, Dominik, Martin Friedrich, and Tim A. Osswald. "Additive Manufacturing." In Understanding Polymer Processing, 147–69. München: Carl Hanser Verlag GmbH & Co. KG, 2017. http://dx.doi.org/10.3139/9781569906484.007.

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de Witte, Dennis. "Additive Manufacturing." In Clay Printing, 53–81. Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-37161-6_5.

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Byskov, Jeppe, and Nikolaj Vedel-Smith. "Additive Manufacturing." In The Future of Smart Production for SMEs, 357–62. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-15428-7_32.

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Agarwal, Raj, Shrutika Sharma, Vishal Gupta, Jaskaran Singh, and Kanwaljit Singh Khas. "Additive manufacturing." In Additive Manufacturing, 77–97. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003258391-5.

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Dev, Saty, Rajeev Srivastava, Pushpendra Yadav, and Surya Prakash. "Additive Manufacturing." In Sustainability, Innovation and Procurement, 27–59. Boca Raton, FL : CRC Press/Taylor & Francis, 2020. |: CRC Press, 2019. http://dx.doi.org/10.1201/9780429430695-2.

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Gebhardt, Andreas, and Jan-Steffen Hötter. "Basics, Definitions, and Application Levels." In Additive Manufacturing, 1–19. München: Carl Hanser Verlag GmbH & Co. KG, 2016. http://dx.doi.org/10.3139/9781569905838.001.

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Conference papers on the topic "Bioinks or Additive manufacturing"

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Wu, Dazhong, Changxue Xu, and Srikumar Krishnamoorthy. "Predictive Modeling of Droplet Velocity and Size in Inkjet-Based Bioprinting." In ASME 2018 13th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/msec2018-6513.

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Additive manufacturing is driving major innovations in many areas such as biomedical engineering. Recent advances have enabled 3D printing of biocompatible materials and cells into complex 3D functional living tissues and organs using bioink. Inkjet-based bioprinting fabricates the tissue and organ constructs by ejecting droplets onto a substrate. Compared with microextrusion-based and laser-assisted bioprinting, it is very difficult to predict and control the droplet formation process (e.g., droplet velocity and size). To address this issue, this paper presents a new data-driven approach to predict droplet velocity and size in the inkjet-based bioprinting process. An imaging system was used to monitor the droplet formation process. To investigate the effects of excitation voltage, dwell time, and rise time on droplet velocity and droplet size, a full factorial design of experiments was conducted. Two predictive models were developed to predict droplet velocity and droplet size using random forests. The accuracy of the two predictive models was evaluated using the relative error. Experimental results have shown that the predictive models are capable of predicting droplet velocity and size with sufficient accuracy.
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Kryou, Christina, Panos Karakaidos, Symeon Papazoglou, Apostolos Klinakis, and Ioanna Zergioti. "Laser bioprinting and laser photo-crosslinking of cell-laden bioinks." In Laser 3D Manufacturing IX, edited by Henry Helvajian, Bo Gu, and Hongqiang Chen. SPIE, 2022. http://dx.doi.org/10.1117/12.2607113.

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Chansoria, Parth, and Rohan Shirwaiker. "Ultrasonically-Induced Patterning of Viable Cells in Viscous Bioinks During 3D Biofabrication." In ASME 2019 14th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/msec2019-2816.

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Abstract In attempts to engineer human tissues in the lab, bio-mimicking the cellular arrangement of natural tissues is critical to achieve the required biological and mechanical form and function. Although biofabrication employing cellular bioinks continues to evolve as a promising solution over polymer scaffold based techniques in creating complex multi-cellular tissues, the ability of most current biofabrication processes to mimic the requisite cellular arrangement is limited. In this study, we propose a novel biofabrication approach that uses forces generated by bulk standing acoustic waves (BSAW) to non-deleteriously align cells within viscous bioinks. We computationally determine the acoustic pressure pattern generated by BSAW and experimentally map the effects of BSAW frequency (0.71, 1, 1.5, 2 MHz) on the linear arrangement of two types of human cells (adipose-derived stem cells and MG63) in alginate. Computational results indicate a non-linear relationship between frequency and acoustic pressure amplitude. Experimental results demonstrate that the spacing between adjacent strands of aligned cells is affected by frequency (p < 0.0001), and this effect is independent of the cell type. Lastly, we demonstrate a synergistic technique of gradual crosslinking in tandem with the BSAW-induced alignment to entrap cells within crosslinked hydrogels. This study represents an advancement in engineered tissue biofabrication aimed at bio-mimicry.
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Wakimoto, Tomomasa, Ryoma Takamori, Soya Eguchi, and Hiroya Tanaka. "Growable Robot with 'Additive-Additive-Manufacturing'." In CHI '18: CHI Conference on Human Factors in Computing Systems. New York, NY, USA: ACM, 2018. http://dx.doi.org/10.1145/3170427.3188449.

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Jerpseth, Laura, Ketan Thakare, Zhijian Pei, and Hongmin Qin. "Experimental Investigation of Effects of Extrusion Pressure on Cell Growth of Bioprinted Algae Cells in Green Bioprinting." In ASME 2020 15th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/msec2020-8481.

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Abstract In bioprinting, biomaterials are deposited layer-by-layer to fabricate structures. Bioprinting has many potential applications in drug screening, tissue engineering, and regenerative medicine. Both animal cells and plant cells can be used to synthesize bioinks. Green bioprinting uses bioinks that have been synthesized using plant cells. Constructs fabricated via green bioprinting contain immobilized plant cells, with these cells arranged at desired locations. The constructs provide scaffolds for cell growth. Printing parameters affecting the growth of cells in green bioprinted constructs include print speed, needle diameter, extrusion temperature, and extrusion pressure. This paper reports a study to examine effects of extrusion pressure on cell growth (measured by cell count) in bioprinted constructs, using bioink containing Chlamydomonas reinhardtii algae cells. Three levels of extrusion pressure were used: 3, 5, and 7 bar. Cell counts in the bioprinted constructs were measured on the third and sixth days after bioprinting. It was found that, as extrusion pressure increased, cell count decreased on both the third and sixth days after bioprinting. Furthermore, the difference in cell counts between the third and the sixth days decreased as extrusion pressure increased. These trends suggest that increasing extrusion pressure during green bioprinting negatively affects cell growth. A possible reason for these trends is physical damage to or death of cells in the bioprinted constructs when extrusion pressure became higher.
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Cleary, William, Clinton Armstrong, David Huegel, and Thomas Pomorski. "Additive Manufacturing at Westinghouse." In 2021 28th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/icone28-68543.

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Abstract Additive manufacturing (AM) is an enabling technology for novel designs and complex shapes that cannot be produced using traditional manufacturing methods. For many nuclear applications, AM could help streamline manufacturing and the supply chain, and could potentially reduce production costs while achieving higher performance through improved heat transfer, thermal hydraulic (T/H) performance, material life and accident tolerance. These benefits would improve fuel reliability and operating margins. Additionally, there are a significant number of potential applications for light water reactors (LWRs) and next generation reactors. AM is also opening the potential to produce obsolete and legacy components which could enable plants to continue operations expediently as well as economically. The use of reverse engineering to digitize components lends itself to AM as this is the first step in producing a component with AM. The NRC (Nuclear Regulatory Commission) is actively engaged in the evaluation of AM as well as other Advanced Manufacturing Techniques to better regulate their usage as needed. Engagement with the NRC is important to ensure regulations are grounded in understanding these technologies. Several examples of additive manufacturing use, to improve performance and capabilities, are presented.
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Jordan, S., and M. DeBruin. "Additive Manufacturing Evaporative Casting." In MS&T17. MS&T17, 2017. http://dx.doi.org/10.7449/2017/mst_2017_281_288.

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Jordan, S., and M. DeBruin. "Additive Manufacturing Evaporative Casting." In MS&T17. MS&T17, 2017. http://dx.doi.org/10.7449/2017mst/2017/mst_2017_281_288.

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Choi, J., C. Johnson, and C. Pringle. "Freeform Additive Manufacturing Lab." In MS&T19. TMS, 2019. http://dx.doi.org/10.7449/2019mst/2019/mst_2019_246_253.

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"Embedded Tutorial: Additive Manufacturing." In 2020 36th Semiconductor Thermal Measurement, Modeling & Management Symposium (SEMI-THERM). IEEE, 2020. http://dx.doi.org/10.23919/semi-therm50369.2020.9142856.

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Reports on the topic "Bioinks or Additive manufacturing"

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Schraad, Mark William, and Marianne M. Francois. ASC Additive Manufacturing. Office of Scientific and Technical Information (OSTI), June 2015. http://dx.doi.org/10.2172/1186037.

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Crain, Zoe, and Roberta Ann Beal. Additive Manufacturing Overview. Office of Scientific and Technical Information (OSTI), June 2018. http://dx.doi.org/10.2172/1441284.

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Murph, S. NANO-ADDITIVE MANUFACTURING. Office of Scientific and Technical Information (OSTI), October 2019. http://dx.doi.org/10.2172/1572880.

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Korinko, P., A. Duncan, A. D'Entremont, P. Lam, E. Kriikku, J. Bobbitt, W. Housley, M. Folsom, and (USC), A. WIRE ARC ADDITIVE MANUFACTURING. Office of Scientific and Technical Information (OSTI), September 2018. http://dx.doi.org/10.2172/1475286.

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Peterson, Dominic S. Additive Manufacturing for Ceramics. Office of Scientific and Technical Information (OSTI), January 2014. http://dx.doi.org/10.2172/1119593.

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Pepi, Marc S., Todd Palmer, Jennifer Sietins, Jonathan Miller, Dan Berrigan, and Ricardo Rodriquez. Advances in Additive Manufacturing. Fort Belvoir, VA: Defense Technical Information Center, July 2016. http://dx.doi.org/10.21236/ad1012134.

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Torres Chicon, Nesty. Additive Manufacturing Technologies Survey. Office of Scientific and Technical Information (OSTI), August 2020. http://dx.doi.org/10.2172/1658439.

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Dehoff, Ryan R., and Michael M. Kirka. Additive Manufacturing of Porous Metal. Office of Scientific and Technical Information (OSTI), June 2017. http://dx.doi.org/10.2172/1362246.

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Sbriglia, Lexey Raylene. Embedding Sensors During Additive Manufacturing. Office of Scientific and Technical Information (OSTI), August 2015. http://dx.doi.org/10.2172/1209455.

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10

Grote, Christopher John. The Frontiers of Additive Manufacturing. Office of Scientific and Technical Information (OSTI), March 2016. http://dx.doi.org/10.2172/1240803.

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