Journal articles: 'Biodistribution studies'

1

Begent, R. H. J., and K. D. Bagshawe. "Biodistribution studies." Advanced Drug Delivery Reviews 22, no. 3 (December 1996): 325–29. http://dx.doi.org/10.1016/s0169-409x(96)00442-5.

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Silva Lima, Beatriz, and Mafalda Ascensão Videira. "Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies." Molecular Therapy - Methods & Clinical Development 8 (March 2018): 183–97. http://dx.doi.org/10.1016/j.omtm.2018.01.003.

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Huang, Ying, Mike Havert, Denise Gavin, Mercedes Serabian, Lee Lee Ong, Maritza C. McIntyre, Nicolas Ferry, et al. "Biodistribution studies: understanding international expectations." Molecular Therapy - Methods & Clinical Development 3 (2016): 16022. http://dx.doi.org/10.1038/mtm.2016.22.

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Castro-Balado, Ana, Cristina Mondelo-García, Miguel González-Barcia, Irene Zarra-Ferro, Francisco J. Otero-Espinar, Álvaro Ruibal-Morell, Pablo Aguiar, and Anxo Fernández-Ferreiro. "Ocular Biodistribution Studies Using Molecular Imaging." Pharmaceutics 11, no. 5 (May 16, 2019): 237. http://dx.doi.org/10.3390/pharmaceutics11050237.

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Classical methodologies used in ocular pharmacokinetics studies have difficulties to obtain information about topical and intraocular distribution and clearance of drugs and formulations. This is associated with multiple factors related to ophthalmic physiology, as well as the complexity and invasiveness intrinsic to the sampling. Molecular imaging is a new diagnostic discipline for in vivo imaging, which is emerging and spreading rapidly. Recent developments in molecular imaging techniques, such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI), allow obtaining reliable pharmacokinetic data, which can be translated into improving the permanence of the ophthalmic drugs in its action site, leading to dosage optimisation. They can be used to study either topical or intraocular administration. With these techniques it is possible to obtain real-time visualisation, localisation, characterisation and quantification of the compounds after their administration, all in a reliable, safe and non-invasive way. None of these novel techniques presents simultaneously high sensitivity and specificity, but it is possible to study biological procedures with the information provided when the techniques are combined. With the results obtained, it is possible to assume that molecular imaging techniques are postulated as a resource with great potential for the research and development of new drugs and ophthalmic delivery systems.

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Gonçalves, C., M. F. M. Ferreira, A. C. Santos, M. I. M. Prata, C. F. G. C. Geraldes, J. A. Martins, and F. M. Gama. "Studies on the biodistribution of dextrin nanoparticles." Nanotechnology 21, no. 29 (July 5, 2010): 295103. http://dx.doi.org/10.1088/0957-4484/21/29/295103.

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Ferreira de Carvalho Patricio, Beatriz, Maria Helena Madruga Lima-Ribeiro, Maria Tereza dos Santos Correia, Ana Maria dos Anjos Carneiro-Leão, Marta de Souza Albernaz, Thiago Barboza, Sergio Augusto Lopes de Souza, and Ralph Santos-Oliveira. "Radiolabeling of Cramoll 1,4: Evaluation of the Biodistribution." International Journal of Peptides 2011 (June 30, 2011): 1–3. http://dx.doi.org/10.1155/2011/945397.

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The cramoll 1,4 is a well-studied lectin. However, few studies about its biodistribution have been done before. In this study, we radiolabeled the cramol 1,4 with Tc-99m and analyzed the biodistribution. The results showed that the cramol has an abnormal uptake by the bowel with reflections on its clearance mechanism.

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Simões, Ana V. C., Sara M. A. Pinto, Mário J. F. Calvete, Célia M. F. Gomes, Nuno C. Ferreira, Miguel Castelo-Branco, Jordi Llop, Mariette M. Pereira, and Antero J. Abrunhosa. "Synthesis of a new 18F labeled porphyrin for potential application in positron emission tomography. In vivo imaging and cellular uptake." RSC Advances 5, no. 120 (2015): 99540–46. http://dx.doi.org/10.1039/c5ra16103g.

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Synthesis, labeling and initial biodistribution studies of a new [¹⁸F] radiolabeled meso-tetraphenylporphyrin (radiochemical purity >95%). Includes human bladder tumor cell uptake and biodistribution data.

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Angra, Pawan K., Aladin Siddig, Henry Nettey, Nishil Desai, Carl Oettinger, and Martin J. D'Souza. "Pharmacokinetic and biodistribution studies of Amphotericin B microspheres." Journal of Microencapsulation 26, no. 7 (November 2009): 627–34. http://dx.doi.org/10.3109/02652040802587173.

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Ding, Hong, and Fang Wu. "Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics." Theranostics 2, no. 11 (2012): 1040–53. http://dx.doi.org/10.7150/thno.4652.

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Acar, Çigdem, Serap Teksöz, Perihan Ünak, F. Zümrüt Biber Müftüler, and E. Ilker Medine. "Somatostatin with 99mTc and Biodistribution Studies in Rats." Cancer Biotherapy and Radiopharmaceuticals 22, no. 6 (December 2007): 748–54. http://dx.doi.org/10.1089/cbr.2007.0340.

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YOSHIOKA, Yasuo. "NanoSafety Studies of Nanomaterials about Biodistribution and Immunotoxicity." YAKUGAKU ZASSHI 131, no. 2 (February 1, 2011): 221–24. http://dx.doi.org/10.1248/yakushi.131.221.

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Qingnuan, Li, Zhang Xiaodong, Sheng Rong, and Li Wenxin. "Preparation of () Re-AEDP and its biodistribution studies." Applied Radiation and Isotopes 53, no. 6 (December 2000): 993–97. http://dx.doi.org/10.1016/s0969-8043(99)00271-7.

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Danis, A., M. Cucu, G. Dumitrescu, M. Ciubotariu, D. Dorcioman, and E. Iancu. "Uranium internal contamination studies. Biodistribution, retention and elimination." Radiation Measurements 25, no. 1-4 (January 1995): 351–54. http://dx.doi.org/10.1016/1350-4487(95)00112-r.

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Epaule, Céline, Andrey Maksimenko, Gérard Bastian, Joachim Caron, Didier Desmaële, Fatima Zouhiri, Patrick Couvreur, and Jean Doucet. "X-ray microfluorescence for biodistribution studies of nanomedicines." International Journal of Pharmaceutics 531, no. 1 (October 2017): 343–49. http://dx.doi.org/10.1016/j.ijpharm.2017.08.106.

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15

Cekic, Betul, Ayfer Yurt Kilcar, Fazilet Zumrut Biber Muftuler, Perihan Unak, and Emin Ilker Medine. "Radiolabeling of methanol extracts of yarrow (Achillea millefolium l) in rats." Acta Cirurgica Brasileira 27, no. 5 (May 2012): 294–300. http://dx.doi.org/10.1590/s0102-86502012000500003.

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PURPOSE: Current study is focused on extraction with methanol, purification, labeling with 131I using iodogen method of the yarrow plant and investigating in vivo biological activity using biodistribution and imaging studies on healthy animal models. The aim of the study is to contribute plant extracts to discover new drugs in the diagnosis and treatment of several diseases. METHODS: Nine female and nine male healthy Wistar albino rats, which were approximately 100-150 g in weight, were used for biodistribution studies. For imaging studies four healthy male Balb-C mice were used. Quality control studies were done utilizing thin layer radio chromatography (TLRC) and high performance liquid chromatography (HPLC) methods. For biodistribution studies, 131I radiolabeled Peak 7 (131I-Peak 7) was sterilized and injected into the tail veil of rats and imaging studies were obtained using Kodak FX PRO in vivo Imaging System. RESULTS: The radiolabeling yield of each purified the bioactive extracts of the yarrow plant, seven peaks was between 79 and 92%. The highest radiolabeling yield was calculated for 131I radiolabeled seventh peak (131I-Peak 7) (92.78±5.04, n=5). For this reason the biodistribution and imaging studies were done for 131I-Peak 7. That's why; these studies with Peak 7 were carried out. CONCLUSION: Peak 7 was radiolabeled with 131I in high yield for using imaging and therapeutic studies in nuclear medical applications.

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Cekic, Betul, Fazilet Zumrut Biber Muftuler, Ayfer Yurt Kılcar, Cigdem Ichedef, and Perihan unak. "Effects of broccoli extract on biodistribution and labeling blood components with 99mTc-GH." Acta Cirurgica Brasileira 26, no. 5 (October 2011): 339–45. http://dx.doi.org/10.1590/s0102-86502011000500003.

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PURPOSE: People consume vegetables without the knowledge of the side effects of the biological and chemical contents and interactions between radiopharmaceuticals and herbal extract. To this end, current study is focused on the effects of broccoli extract on biodistribution of radiolabeled glucoheptonate (99mTc-GH) and radiolabeling of blood components. METHODS: GH was labeled with 99mTc. Quality control studies were done utilizing TLC method. Biodistribution studies were performed on male rats which were treated via gavage with either broccoli extract or SF as control group for 15 days. Blood samples were withdrawn from rats' heart. Radiolabeling of blood constituents performed incubating with GH, SnCl2 and 99m Tc. RESULTS: Radiochemical yield of 99mTc-GH is 98.46±1.48 % (n=8). Biodistribution studies have shown that according to the control, the treated group with broccoli has approximately 10 times less uptake in kidney. The percentage of the radioactivity ratios of the blood components is found to be same in both groups. CONCLUSIONS: Although there is no considerable effect on the radiolabeling of blood components, there is an outstanding change on the biodistribution studies especially on kidneys. The knowledge of this change on kidney uptake may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in Nuclear Medicine.

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Khmelev, A. "Topical Issues of Radiopharmaceuticals Appliance in PET Studies." Medical Radiology and radiation safety 66, no. 5 (November 2, 2021): 66–77. http://dx.doi.org/10.12737/1024-6177-2021-66-5-66-77.

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CONTENT Introduction 1. Requirements to radiopharmaceuticals 2. Factors affecting the biodistribution in organism 3. Uptake and localization mechanisms 4. Appliance in PET studies of biological processes and diagnostics 5. Aspects of regulation of radiopharmaceuticals circulation Conclusion

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Pena-Rodríguez, Eloy, Maria Lajarin-Reinares, Aida Mata-Ventosa, Sandra Pérez-Torras, and Francisco Fernández-Campos. "Dexamethasone-Loaded Lipomers: Development, Characterization, and Skin Biodistribution Studies." Pharmaceutics 13, no. 4 (April 11, 2021): 533. http://dx.doi.org/10.3390/pharmaceutics13040533.

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Follicular targeting has gained more attention in recent decades, due to the possibility of obtaining a depot effect in topical administration and its potential as a tool to treat hair follicle-related diseases. Lipid core ethyl cellulose lipomers were developed and optimized, following which characterization of their physicochemical properties was carried out. Dexamethasone was encapsulated in the lipomers (size, 115 nm; polydispersity, 0.24; zeta-potential (Z-potential), +30 mV) and their in vitro release profiles against dexamethasone in solution were investigated by vertical diffusion Franz cells. The skin biodistribution of the fluorescent-loaded lipomers was observed using confocal microscopy, demonstrating the accumulation of both lipomers and fluorochromes in the hair follicles of pig skin. To confirm this fact, immunofluorescence of the dexamethasone-loaded lipomers was carried out in pig hair follicles. The anti-inflammatory (via TNFα) efficacy of the dexamethasone-loaded lipomers was demonstrated in vitro in an HEK001 human keratinocytes cell culture and the in vitro cytotoxicity of the nanoformulation was investigated.

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19

Biber Muftuler, F. Z., P. Unak, S. Teksoz, C. Acar, S. Yolcular, and Y. Yürekli. "131I labeling of tamoxifen and biodistribution studies in rats." Applied Radiation and Isotopes 66, no. 2 (February 2008): 178–87. http://dx.doi.org/10.1016/j.apradiso.2007.08.005.

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20

Caiolfa, V. R., M. Zamai, A. Fiorino, E. Frigerio, C. Pellizzoni, R. d’Argy, A. Ghiglieri, et al. "Polymer-bound camptothecin: initial biodistribution and antitumour activity studies." Journal of Controlled Release 65, no. 1-2 (March 2000): 105–19. http://dx.doi.org/10.1016/s0168-3659(99)00243-6.

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21

Henriksen-Lacey, Malou, Vincent Bramwell, and Yvonne Perrie. "Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution Studies." Pharmaceutics 2, no. 2 (March 31, 2010): 91–104. http://dx.doi.org/10.3390/pharmaceutics2020091.

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22

Unak, P., F. Y. Lambrecht, F. Z. Biber, İ. E. Medine, and S. Teksoz. "Labeling of famotidine with99mTc and biodistribution studies on rats." Journal of Radioanalytical and Nuclear Chemistry 261, no. 3 (2004): 587–91. http://dx.doi.org/10.1023/b:jrnc.0000037099.75789.29.

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23

Schott, Margaret E., Jeffrey Schlom, Kathleen Siler, Diane E. Milenic, Diane Eggensperger, David Colcher, Roberta Cheng, W. Jack Kruper, William Fordyce, and William Goeckeler. "Biodistribution and preclinical radioimmunotherapy studies using radiolanthanide-labeled immunoconjugates." Cancer 73, S3 (February 1, 1994): 993–98. http://dx.doi.org/10.1002/1097-0142(19940201)73:3+<993::aid-cncr2820731337>3.0.co;2-7.

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Berridge, Marc S., Donald L. Heald, and Zhenghong Lee. "Imaging studies of biodistribution and kinetics in drug development." Drug Development Research 59, no. 2 (June 2003): 208–26. http://dx.doi.org/10.1002/ddr.10220.

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Hu, Xiao, Fei-Fei Yang, Li-Hui Quan, Chun-Yu Liu, Xin-Min Liu, Carsten Ehrhardt, and Yong-Hong Liao. "Pulmonary delivered polymeric micelles – Pharmacokinetic evaluation and biodistribution studies." European Journal of Pharmaceutics and Biopharmaceutics 88, no. 3 (November 2014): 1064–75. http://dx.doi.org/10.1016/j.ejpb.2014.10.010.

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26

Mäkilä⁎, J. A., A. Kiviniemi, H. Liljenbäck, J. Mäkelä, T. Saanijoki, P. Virta, H. Lönnberg, T. Laitala-Leinonen, and A. Roivainen. "Preclinical biodistribution studies of 68Ga-labeled anti-miR15b molecules." Bone 50 (May 2012): S90—S91. http://dx.doi.org/10.1016/j.bone.2012.02.269.

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27

Fernández-Moreira, Vanesa, Juan V. Alegre-Requena, Raquel P. Herrera, Isabel Marzo, and M. Concepción Gimeno. "Synthesis of luminescent squaramide monoesters: cytotoxicity and cell imaging studies in HeLa cells." RSC Advances 6, no. 17 (2016): 14171–77. http://dx.doi.org/10.1039/c5ra24521d.

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Luminescent squaramide monoesters functionalised with fluorophore groups have been explored as cytotoxic and imaging agents. The biodistribution behaviour differs depending on the fluorescent moiety; lysosomal and nuclear localisation have been observed.

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Moholkar, Disha Nagesh, Raghuram Kandimalla, Farrukh Aqil, and Ramesh Gupta. "Abstract 372: Biodistribution and tumor targeting of exosomes using mouse models." Cancer Research 82, no. 12_Supplement (June 15, 2022): 372. http://dx.doi.org/10.1158/1538-7445.am2022-372.

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Abstract Biodistribution studies are relevant models for understanding the fundamental preclinical information of the distribution of drugs to the potential target organs, which provide insight on which on-target or off-target effects might be expected. One of our research focuses is the study of uptake and distribution of bovine milk- and colostrum-derived exosomes, functionalized exosomes and exosomes in polyethyleneimine (PEI) matrix (EPM) using near-infrared fluorescent dye in rodents. Previously, when DiR dye was loaded onto milk exosomes, biodistribution studies showed that route of administration had a significant influence on the tissue distribution with somewhat uniform biodistribution with oral gavage while predominated liver accumulation with the i.v. route. In this study, we show biodistribution of colostrum exosomes, EPM and tumor targeting by attaching tumor targeting ligand, folic acid (FA). We studied the biodistribution of these formulations using exosomes labeled with Alexa Fluor 750 (AF750) in wild-type mice and subcutaneous lung tumor-bearing mice. In various studies we tested: i) biodistribution of exosomes vs EPM, ii) effect of different administration routes such as intravenous (i.v.), oral (p.o.), subcutaneous (s.c.), intranasal (i.n.) and intramuscular (i.m.) on biodistribution, and iii) tumor targeting using FA-functionalized exosomes and EPM. Uniform tissue distribution was observed upon oral administration of exosomes while predominant hepatic accumulation was observed with i.v. administration. The i.n. route resulted in pre-dominant accumulation in lung, whereas i.m. and s.c. delivery had almost similar distribution as observed with i.v. route. The distribution of exosomes and EPM matrix was largely similar. We observed that the fluorescent signals from AF750-labeled FA-Exo and FA-EPM treatment revealed higher tumor accumulation of exosomes as compared to non-functionalized exosomes and EPM, respectively due to overexpression of folate receptors. Time-dependent distribution showed accumulation of EPM in tumors at later time point. The EPM formulations could be detected at the sites otherwise difficult to target such as brain and lymph nodes after systemic administration, thus indicating suitability of these formulations to cross physiological barriers. To validate the therapeutic potential, FA-EPM was loaded with 15 μg siKRAS and injected intravenously to orthotopic A549 lung tumor-bearing mice. Significant reduction in tumor volume (67%; p <0.001) and tumor weight (76%; p <0.001) was observed which corroborated the significant knockdown of KRAS protein (p <0.01). Thus, this novel approach can be used as a nano ‘platform’ for drug delivery due to its increased circulating half-life, high uptake by target cells, and ability to load a diverse range of pharmaceutical therapeutics including biologics such as siRNA. (Supported from Duggan Endowment and 3P biotechnologies, Inc.) Citation Format: Disha Nagesh Moholkar, Raghuram Kandimalla, Farrukh Aqil, Ramesh Gupta. Biodistribution and tumor targeting of exosomes using mouse models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 372.

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29

Song, Wantong, Zhaohui Tang, Dawei Zhang, Neal Burton, Wouter Driessen, and Xuesi Chen. "Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography." RSC Advances 5, no. 5 (2015): 3807–13. http://dx.doi.org/10.1039/c4ra09735a.

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30

England, Christopher G., Emily B. Ehlerding, Reinier Hernandez, Brian T. Rekoske, Stephen A. Graves, Haiyan Sun, Glenn Liu, Douglas G. McNeel, Todd E. Barnhart, and Weibo Cai. "Preclinical Pharmacokinetics and Biodistribution Studies of 89 Zr-Labeled Pembrolizumab." Journal of Nuclear Medicine 58, no. 1 (August 4, 2016): 162–68. http://dx.doi.org/10.2967/jnumed.116.177857.

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31

Kamiyama, Yoshiteru, Yoichi Naritomi, Yuu Moriya, Syunsuke Yamamoto, Tsukasa Kitahashi, Toshihiko Maekawa, Masahiro Yahata, et al. "Biodistribution studies for cell therapy products: Current status and issues." Regenerative Therapy 18 (December 2021): 202–16. http://dx.doi.org/10.1016/j.reth.2021.06.005.

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32

Falzarano, Maria Sofia, Elena Bassi, Chiara Passarelli, Paola Braghetta, and Alessandra Ferlini. "Biodistribution Studies of Polymeric Nanoparticles for Drug Delivery in Mice." Human Gene Therapy 25, no. 11 (November 2014): 927–28. http://dx.doi.org/10.1089/hum.2014.073.

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Hendrickson, O. D., A. V. Zherdev, I. V. Gmoshinskii, and B. B. Dzantiev. "Fullerenes: In vivo studies of biodistribution, toxicity, and biological action." Nanotechnologies in Russia 9, no. 11-12 (November 2014): 601–17. http://dx.doi.org/10.1134/s199507801406010x.

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34

Novakova, K., M. Laznicek, F. Rypacek, and L. Machova. "125I-Labeled PLA/PEO Block Copolymer: Biodistribution Studies in Rats." Journal of Bioactive and Compatible Polymers 17, no. 4 (July 2002): 285–96. http://dx.doi.org/10.1106/088391102027534.

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35

Kainthan, Rajesh Kumar, and Donald E. Brooks. "Unimolecular Micelles based on Hydrophobically Derivatized Hyperbranched Polyglycerols: Biodistribution Studies." Bioconjugate Chemistry 19, no. 11 (November 19, 2008): 2231–38. http://dx.doi.org/10.1021/bc800090v.

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Mladenovska, K., I. E. Janevik, D. M. Glavas, F. E. Kumbaradzi, and K. Goracinova. "Biodistribution studies of BSA loaded gelatin microspheres after peroral application." International Journal of Pharmaceutics 242, no. 1-2 (August 2002): 251–53. http://dx.doi.org/10.1016/s0378-5173(02)00168-0.

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Hendrickson, Olga D., Sergey G. Klochkov, Oksana V. Novikova, Irina M. Bravova, Elena F. Shevtsova, Irina V. Safenkova, Anatoly V. Zherdev, Sergey O. Bachurin, and Boris B. Dzantiev. "Toxicity of nanosilver in intragastric studies: Biodistribution and metabolic effects." Toxicology Letters 241 (January 2016): 184–92. http://dx.doi.org/10.1016/j.toxlet.2015.11.018.

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Qingnuan, Li, Xiu yan, Zhang Xiaodong, Liu Ruili, Du qieqie, Shun Xiaoguang, Chen Shaoliang, and Li Wenxin. "Preparation of 99mTc-C60(OH)x and its biodistribution studies." Nuclear Medicine and Biology 29, no. 6 (August 2002): 707–10. http://dx.doi.org/10.1016/s0969-8051(02)00313-x.

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39

Tesan, Fiorella, Cristal Cerqueira-Coutinho, Jimena Salgueiro, Marta de Souza Albernaz, Suyenne Rocha Pinto, Sara Rhaissa Rezende Dos Reis, Emerson Soares Bernardes, Diego Chiapetta, Marcela Zubillaga, and Ralph Santos-Oliveira. "Characterization and biodistribution of bevacizumab TPGS-based nanomicelles: Preliminary studies." Journal of Drug Delivery Science and Technology 36 (December 2016): 95–98. http://dx.doi.org/10.1016/j.jddst.2016.09.011.

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Novais, C. M., P. B. Pujatti, M. A. S. Castro, M. A. Soares, M. E. De Lima, C. Simal, and R. Gouv?a dos Santos. "99mTc radiolabeling of crotoxin as a tool for biodistribution studies." Journal of Radioanalytical and Nuclear Chemistry 269, no. 3 (September 2006): 591–95. http://dx.doi.org/10.1007/s10967-006-0270-y.

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Zhang, Zizhu, Zhong Yong, Congjun Jin, Zewen Song, Shaihong Zhu, Tong Liu, Yang Chen, Yizheng Chong, Xinru Chen, and Yongmao Zhou. "Biodistribution studies of boronophenylalanine in different types of skin melanoma." Applied Radiation and Isotopes 163 (September 2020): 109215. http://dx.doi.org/10.1016/j.apradiso.2020.109215.

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Esmaeili, Farnaz, Rassoul Dinarvand, Mohammad Hossein Ghahremani, Mohsen Amini, Hasti Rouhani, Nima Sepehri, Seyed Nasser Ostad, and Fatemeh Atyabi. "Docetaxel–Albumin Conjugates: Preparation, In Vitro Evaluation and Biodistribution Studies." Journal of Pharmaceutical Sciences 98, no. 8 (August 2009): 2718–30. http://dx.doi.org/10.1002/jps.21599.

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Sun, Hui, Quanwei Yin, Aihua Zhang, and Xijun Wang. "UPLC-MS/MS performing pharmacokinetic and biodistribution studies of rhein." Journal of Separation Science 35, no. 16 (July 2, 2012): 2063–68. http://dx.doi.org/10.1002/jssc.201200378.

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Patt, J. T., J. E. Spang, G. Westera, and P. A. Schubiger. "[C-11]N-methylhomoepibatidine: radiolabelling and biodistribution studies in mice." Journal of Labelled Compounds and Radiopharmaceuticals 43, no. 2 (February 2000): 127–36. http://dx.doi.org/10.1002/(sici)1099-1344(200002)43:2<127::aid-jlcr299>3.0.co;2-u.

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Saidi, Mouldi, K. Kothari, M. R. A. Pillai, Amri Hassan, H. D. Sarma, P. R. Chaudhari, T. P. Unnikrishnan, A. Korde, and Zohra Azzouz. "Cyclopentadienyl technetium (99mTc) tricarbonyl piperidine conjugates: biodistribution and imaging studies." Journal of Labelled Compounds and Radiopharmaceuticals 44, no. 9 (2001): 603–18. http://dx.doi.org/10.1002/jlcr.491.

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Urbano, Nicoletta, Manuel Scimeca, Anna Tolomeo, Vincenzo Dimiccoli, Elena Bonanno, and Orazio Schillaci. "Novel Biological and Molecular Characterization in Radiopharmaceutical Preclinical Design." Journal of Clinical Medicine 10, no. 21 (October 21, 2021): 4850. http://dx.doi.org/10.3390/jcm10214850.

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In this study, the potential of a digital autoradiography system equipped with a super resolution screen has been evaluated to investigate the biodistribution of a 18F-PSMA inhibitor in a prostate cancer mouse model. Twelve double xenograft NOD/SCID mice (LNCAP and PC3 tumours) were divided into three groups according to post-injection time points of an 18F-PSMA inhibitor. Groups of 4 mice were used to evaluate the biodistribution of the radiopharmaceutical after 30-, 60- and 120-min post-injection. Data here reported demonstrated that the digital autoradiography system is suitable to analyse the biodistribution of an 18F-PSMA inhibitor in both whole small-animal bodies and in single organs. The exposure of both whole mouse bodies and organs on the super resolution screen surface allowed the radioactivity of the PSMA inhibitor distributed in the tissues to be detected and quantified. Data obtained by using a digital autoradiography system were in line with the values detected by the activity calibrator. In addition, the image obtained from the super resolution screen allowed a perfect overlap with the tumour images achieved under the optical microscope. In conclusion, biodistribution studies performed by the autoradiography system allow the microscopical modifications induced by therapeutic radiopharmaceuticals to be studied by comparing the molecular imaging and histopathological data at the sub-cellular level.

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Visbal, Renso, Vanesa Fernández-Moreira, Isabel Marzo, Antonio Laguna, and M. Concepción Gimeno. "Cytotoxicity and biodistribution studies of luminescent Au(i) and Ag(i) N-heterocyclic carbenes. Searching for new biological targets." Dalton Transactions 45, no. 38 (2016): 15026–33. http://dx.doi.org/10.1039/c6dt02878k.

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Vojtek, Martin, Edgar Pinto, Salomé Gonçalves-Monteiro, Agostinho Almeida, M. P. M. Marques, Helder Mota-Filipe, Isabel M. P. L. V. O. Ferreira, and Carmen Diniz. "Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies." Analytical Methods 12, no. 39 (2020): 4806–12. http://dx.doi.org/10.1039/d0ay01328e.

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The paper describes validated micro-method suitable for quantitative analysis of palladium- and platinum-based anticancer drugs in 11 distinct animal tissues/biofluids obtained from multi-organ pharmacokinetic/biodistribution animal studies.

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Izquierdo-Sánchez, Vanessa, Saé Muñiz-Hernández, Héctor Vázquez-Becerra, Judith Pacheco-Yepez, Mario Romero-Piña, Oscar Arrieta, and Luis Medina. "Biodistribution and Tumor Uptake of 67Ga-Nimotuzumab in a Malignant Pleural Mesothelioma Xenograft." Molecules 23, no. 12 (November 29, 2018): 3138. http://dx.doi.org/10.3390/molecules23123138.

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Malignant pleural mesothelioma (MPM) is the most common tumor of the pulmonary pleura. It is a rare and aggressive malignancy, generally associated with continuous occupational exposure to asbestos. Only a multimodal-approach to treatment, based on surgical resection, chemotherapy and/or radiation, has shown some benefits. However, the survival rate remains low. Nimotuzumab (h-R3), an anti-EGFR (epidermal growth factor receptor) humanized antibody, is proposed as a promising agent for the treatment of MPM. The aim of this research was to implement a procedure for nimotuzumab radiolabeling to evaluate its biodistribution and affinity for EGF (epidermal growth factor) receptors present in a mesothelioma xenograft. Nimotuzumab was radiolabeled with 67Ga; radiolabel efficiency, radiochemical purity, serum stability, and biodistribution were evaluated. Biodistribution and tumor uptake imaging studies by microSPECT/CT in mesothelioma xenografts revealed constant nimotuzumab uptake at the tumor site during the first 48 h after drug administration. In vivo studies using MPM xenografts showed a significant uptake of this radioimmunoconjugate, which illustrates its potential as a biomarker that could promote its theranostic use in patients with MPM.

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Zhang, Bin, Jing Zhu, Hongwei Gu, and Shengming Deng. "Biodistribution and Acute Toxicity of Intravenous Multifunctional 125I-Radiolabeled Fe3O4-Ag Heterodimer Nanoparticles in Mice." Journal of Nanomaterials 2018 (November 11, 2018): 1–6. http://dx.doi.org/10.1155/2018/3150351.

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Fe3O4-Ag125I heterostructured radionuclide nanoparticles (NPs) have been developed as a novel type of dual-modality imaging agents for single-photon emission computerized tomography (SPECT) and magnetic resonance imaging (MRI). However, the biodistribution and toxicity of Fe3O4-Ag125I NPs remain largely unknown. Therefore, we investigated the biodistribution and biological action of Fe3O4-Ag125I NPs in mice by acute toxicity experiments (exposures over 7 days). The bioaccumulation of Fe3O4-Ag125I NPs was studied via in vivo experiments. The serum biochemistry and hematology were analyzed to reveal potential functional changes. The histopathological changes were observed by using an electron microscope. Biodistribution analysis revealed that Fe3O4-Ag125I NPs were mainly accumulated in the liver and spleen. The activities of liver enzymes (ALT and AST) were increased in Fe3O4-Ag125I NP-challenged groups compared with the control groups. Collectively, liver and spleen were the major target organs for accumulation of Fe3O4-Ag125I NPs. Damage of liver tissue was observed in the Fe3O4-Ag125I NP-challenged groups compared with the control groups. Further studies on surface coating of Fe3O4-Ag with targeted materials are highly necessary for safe medical applications of Fe3O4-AgNPs as dual-modality imaging agents.

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Journal articles on the topic 'Biodistribution studies'

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