Relevant bibliographies by topics / Biodegradable polymeric nanoparticles

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Biodegradable polymeric nanoparticles'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Biodegradable polymeric nanoparticles"

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Yuan, Xudong, Ling Li, Appu Rathinavelu, Jinsong Hao, Madhusudhanan Narasimhan, Matthew He, Viviene Heitlage, Linda Tam, Sana Viqar, and Mojgan Salehi. "siRNA Drug Delivery by Biodegradable Polymeric Nanoparticles." Journal of Nanoscience and Nanotechnology 6, no. 9 (September 1, 2006): 2821–28. http://dx.doi.org/10.1166/jnn.2006.436.

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RNA interference (RNAi) is an emerging technology in which the introduction of double-stranded RNA (dsRNA) into a diverse range of organisms and cell types causes degradation of the complementary mRNA. It offers a broad spectrum of applications in both biological and medical research. Small interference RNA (siRNA) was recently explored for its therapeutical potential. However, the drug delivery of siRNA oligos is very novel and is in great need of future research. To this end, a biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle drug carrier system was prepared to load siRNA oligos with desired physicochemical properties. The nanoparticles were characterized by scanning electron microscopy and laser diffraction particle sizer. The delivery of siRNA into the targeted 293T cells was observed using fluorescent-labeled double-stranded Cy3-oligos. The model siRNA oligos, si-GFP-RNA, were also successfully loaded into PLGA nanoparticles and delivered in 293T cells. The gene silencing effect and the inhibition of GFP expression were investigated using fluorescent microscopy. Both positive and negative controls were used to compare with the new siRNA nanoparticle delivery system. It was found that nanoparticles offered both effective delivery of siRNA and prominent GFP gene silencing effect. Compared to conventional carrier systems, the new biodegradable polymeric nanoparticle system may also offer improved formulation stability, which is practically beneficial and may be used in the future clinical studies of siRNA therapeutics.
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Swain, Suryakanta, and Debashish Ghose. "Biodegradable polymeric nanoparticles: An overview." Indian Journal of Pharmacy and Pharmacology 9, no. 3 (August 15, 2022): 141–42. http://dx.doi.org/10.18231/j.ijpp.2022.025.

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Athira TR, K Selvaraju, and NL Gowrishankar. "Biodegradable polymeric nanoparticles: The novel carrier for controlled release drug delivery system." International Journal of Science and Research Archive 8, no. 1 (February 28, 2023): 630–37. http://dx.doi.org/10.30574/ijsra.2023.8.1.0103.

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In the recent decades, polymers are widely used as biomaterials due to their favourable properties such as good biocompatibility, easy design and preparation, structural varieties and interesting bio-mimetic character. The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Concurrently, targeted delivery technologies are becoming increasingly important as a scientific area of investigation. The current review entails an in-depth discussion of biodegradable polymeric nanoparticles with respect to types, formulation aspects as well as site-specific drug targeting using various ligands modifying the surface of polymeric nanoparticles with special insights to the field of oncology. Ultimately the goal of polymeric nanoparticle drug delivery is the emergence of a nano-fabricated therapeutic drug release device with the capacity to enough hold and release of various active agents on demand.
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Patil, Vijay, and Asha Patel. "Biodegradable Nanoparticles: A Recent Approach and Applications." Current Drug Targets 21, no. 16 (December 14, 2020): 1722–32. http://dx.doi.org/10.2174/1389450121666200916091659.

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Biodegradable nanoparticles (NPs) are the novel carriers for the administration of drug molecules. Biodegradable nanoparticles have become popular recently because of their special features such as targeted delivery of drugs, improved bioavailability, and better therapeutic effectiveness to administer the drug at a constant rate. Polymeric NPs are very small-sized polymeric colloidal elements in which a drug of interest may be encapsulated or incorporated in their polymeric network or conjugated or adsorbed on the layer. Various polymers are employed in the manufacturing of nanoparticles, some of the frequently employed polymers are agents, chitosan, cellulose, gelatin, gliadin, polylactic acid, polylactic-co-glycolic acid, and pullulan. Nanoparticles have been progressively explored for the delivery of targeted ARVs to cells of HIV-infected and have performed the prolonged kinetic release. Drug embedded in this system can give better effectiveness, diminished resistance of drugs, reduction in systemic toxicity and symptoms, and also enhanced patient compliance. The present review highlights the frequently employed manufacturing methods for biodegradable nanoparticles, various polymers used, and its application in anti-retroviral therapy. Also, common evaluation parameters to check the purity of nanoparticles, ongoing and recently concluded clinical trials and patents filled by the various researchers, and the future implication of biodegradable NPs in an innovative drug delivery system are described. The biodegradable NPs are promising systems for the administration of a broad variety of drugs including anti-retroviral drugs, and hence biodegradable nanoparticles can be employed in the future for the treatment of several diseases and disorders.
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Karlsson, Johan, Hannah J. Vaughan, and Jordan J. Green. "Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments." Annual Review of Chemical and Biomolecular Engineering 9, no. 1 (June 7, 2018): 105–27. http://dx.doi.org/10.1146/annurev-chembioeng-060817-084055.

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Polymeric nanoparticles have tremendous potential to improve the efficacy of therapeutic cancer treatments by facilitating targeted delivery to a desired site. The physical and chemical properties of polymers can be tuned to accomplish delivery across the multiple biological barriers required to reach diverse subsets of cells. The use of biodegradable polymers as nanocarriers is especially attractive, as these materials can be designed to break down in physiological conditions and engineered to exhibit triggered functionality when at a particular location or activated by an external source. We present how biodegradable polymers can be engineered as drug delivery systems to target the tumor microenvironment in multiple ways. These nanomedicines can target cancer cells directly, the blood vessels that supply the nutrients and oxygen that support tumor growth, and immune cells to promote anticancer immunotherapy.
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Guzman, Luis A., Vinod Labhasetwar, Cunxian Song, Yangsoo Jang, A. Michael Lincoff, Robert Levy, and Eric J. Topol. "Local Intraluminal Infusion of Biodegradable Polymeric Nanoparticles." Circulation 94, no. 6 (September 15, 1996): 1441–48. http://dx.doi.org/10.1161/01.cir.94.6.1441.

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Soppimath, Kumaresh S., Tejraj M. Aminabhavi, Anandrao R. Kulkarni, and Walter E. Rudzinski. "Biodegradable polymeric nanoparticles as drug delivery devices." Journal of Controlled Release 70, no. 1-2 (January 2001): 1–20. http://dx.doi.org/10.1016/s0168-3659(00)00339-4.

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GOMEZGAETE, C., N. TSAPIS, M. BESNARD, A. BOCHOT, and E. FATTAL. "Encapsulation of dexamethasone into biodegradable polymeric nanoparticles." International Journal of Pharmaceutics 331, no. 2 (March 1, 2007): 153–59. http://dx.doi.org/10.1016/j.ijpharm.2006.11.028.

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Kumari, Avnesh, Sudesh Kumar Yadav, and Subhash C. Yadav. "Biodegradable polymeric nanoparticles based drug delivery systems." Colloids and Surfaces B: Biointerfaces 75, no. 1 (January 2010): 1–18. http://dx.doi.org/10.1016/j.colsurfb.2009.09.001.

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Leimann, Fernanda Vitória, Maiara Heloisa Biz, Karine Cristine Kaufmann, Wallace José Maia, Odinei Hess Honçalves, Lucio Cardozo Filho, Claudia Sayer, and Pedro Henrique Hermes de Araújo. "Characterization of progesterone loaded biodegradable blend polymeric nanoparticles." Ciência Rural 45, no. 11 (November 2015): 2082–88. http://dx.doi.org/10.1590/0103-8478cr20141288.

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ABSTRACT: The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV/PLLA blend nanoparticles was investigated in this research. Nanoparticles were produced by miniemulsion/solvent evaporation technique with lecithin as surfactant and were characterized regarding to z-average diameter (Dz) and polydispersity (PDI), progesterone recovery yield and encapsulation efficiency. Possible interactions between progesterone and the polymer matrices were investigated by Fourier Transform Infrared Spectroscopy (FTIR). High recoveries (up to 102.43±1.80% for the PHBV/PLLA blend) and encapsulation efficiencies (up to 99.53±0.04% for PCL) were achieved and the nanoparticles presented narrow size distribution (0.12±0.03 for PLLA). PCL nanoparticles (217.5±2.12nm) presented significant difference with the Dz from all the other formulations (P<0.05). The most evident interaction between progesterone and the nanoparticles polymeric matrix was found to PHBV/PCL due to the increase in the intensity of the band located in 1631 cm-1.
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Dissertations / Theses on the topic "Biodegradable polymeric nanoparticles"

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Jo, Ami. "The Design of Biodegradable Polyester Nanocarriers for Image-guided Therapeutic Delivery." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/97220.

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Multiple hurdles, such as drug solubility, stability, and physical barriers in the body, hinder bioavailability of many promising therapeutics. Polymeric nanocarriers can encapsulate the therapeutics to protect non-target areas from side effects but also protect the drug from premature degradation for increased circulation and bioavailability. To capitalize on these advantages, the polymer nanoparticle must be properly engineered for increased control in size distribution, therapeutic encapsulation, colloidal stability, and release kinetics. However, each application requires a specific set of characteristics and properties. Being able to tailor these by manipulation of different design parameters is essential to optimize nanoparticles for the application of interest. This study of nanoparticle fabrication and characterization takes us a step closer to building effective delivery systems tailored for specific treatments. Poly(ethylene oxide)-b-poly(D,L-lactic acid) (PEO-b-PDLLA) based nanoparticles were produced to range from 100-200 nm in size. They were fluorescently labeled with a hydrophobic dye 6-13 bis(triisopropylsilylethynyl) pentacene (TIPS pentacene) at an optimal loading of 0.5 wt% with respect to the core. Surfaces were successfully coated with streptavidin to be readily functionalized with various biotinylated compounds such as PD-L1 antibodies or A488 fluorophore. Using the same PEO-b-PDLLA, iron oxide and a conjugated polymer poly(2- methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene) (MEH-PPV) were co-encapsulated to form fluorescently labeled magnetic particles. Using poly(lactic-co-glycolic acid), CRISPR-Cas9 plasmids were encapsulated at 1.6 wt% and most of the payload released within the first 24 hours. The incorporated plasmids were intact enough to have mammalian macrophages successfully express the bacterial protein Cas9. Using similar PLGA based particles, the surface was functionalized with streptavidin and bound to the surface of bacteria as an active carrier for increased penetration of solid tumors averaging ~23 particles per bacterium. PEO-b-PLGA based particles were used in conjunction with a hydrophobic salt former to encapsulate a peptide designed to reduce platelet binding to cancer cells and mitigate extravasation. The peptide encapsulated was increased from < 2 wt% without salt former to 8.5 wt% with the used of hexadecyl phosphonic acid. Although the applications across these projects can be broad, the fundamentals and important design parameters considered contribute to the overarching field of effective carriers for drug delivery.
Ph. D.
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Heffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.

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Thesis (Ph.D.)--Biomedical Engineering, Georgia Institute of Technology, 2008.
Committee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.
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COLOMBO, FEDERICO. "Innovative approach for the treatment and the diagnosis of rheumatoid arthritis exploiting polymeric biodegradable nanoparticles targeting synovial endothelium." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2917682.

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Rheumatoid arthritis (RA) is an autoimmune disease affecting joints due to the persistent inflammation of the synovial tissue. It affects 1% of the worldwide population with high socioeconomic costs. Patients usually require lifetime treatments in order to prevent late stage of the disease, which leads to a condition of disability and pain. Despite the introduction of biological drugs, Methotrexate (MTX) is still the gold standard. However, it shows some weakness such as inefficacy or adverse events after long term usage. For this reason, there is the need to develop drugs with an improved safety profile and higher therapeutic efficacy. Moreover, it is of primary importance to develop diagnostics with enhanced sensitivity and tissue specificity. In order to meet these needs, the purpose of this work is to develop a nanotechnological agent capable to delivery its content, such as drugs or diagnostic tracers, specifically into pathological joints, avoiding healthy tissues. These aims have been achieved exploiting peculiar features of biodegradable nanoparticles (BNPs), such as improved pharmacokinetic and bioavailability, associated to a peptide specific for the inflamed synovia. Recently, the heterogeneity of the molecules present in the endothelium has allowed to develop peptides capable to target vessels of specific tissues. In this project, a cyclic peptide able to target the microvasculature of the inflamed synovia has been exploited to drive BNPs only into inflamed joints. BNPs have been characterized for their physicochemical features, polymers’ toxicity and drug release. Targeted polymeric nanoparticles (tBNPs) demonstrated, both in vitro and in vivo, to preferentially bind inflamed synovial tissue, and their accumulation depends from the degree of inflammation. Targeted BNPs loaded with MTX showed higher efficacy compared to free MTX in two different animal models of RA. In addition, reduced dose of tBNPs-MTX demonstrated to maintain its efficacy, showing fewer side effects compared with systemic administration of free MTX. This new therapeutic approach provided a new mechanism of action from approved therapy and suggest potential application in non-responding patients. All these evidences highlight the potential use of tBNPs as biocompatible and adaptable tool for the diagnosis and the treatment of RA showing important efficacy, reduced side effects and with the potential to enhance the sensitivity of several imaging technologies.
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Cella, C. "Development of biodegradable nanoparticles for targeting Tumor Associated Macrophages: synthesis, investigation of the role of the surfactant and surface decoration in complex media." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/366594.

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Tumor Associated Macrophages (TAMs) are involved in cancer proliferation, thus strategies to deplete them represent promising tools for chemotherapy. Pharmacological agents with multiple activities such as curcumin and RNA interference have been proposed; however their employment in therapeutics has been limited because of low systemic bioavailability. Accordingly, this thesis described as an innovative therapeutic approach for cancer treatment the development of polymeric nanoparticles (NPs) able to (i) increase pharmacokinetics properties of biomacromolecules and poor water soluble drugs, and (ii) guarantee TAMs specific targeting. The safe and versatile polymer Poly(Lactic-co-Glycolic)Acid (PLGA) has been used for the synthesis of NPs by both single (OW) and double (WOW) emulsion-solvent evaporation techniques. Different synthetic parameters have been taken into consideration, with particular focus on the surfactant role. As alternative to the commonly used Poly Vinyl Alcohol (PVA), a newly synthetized polymer (amino-PVA) and Calcium Sterate (CSt) have been investigated for their ability to modulate surface charge and biocompatibility. NPs with solid or core-shell structures, whose size was tailored between 200 and 300 nm, were obtained and a thorough characterization has been performed, with the help of innovative techniques such as single particle optical extinction and scattering (SPES) method. Both amino-PVA and CSt stabilized NPs were found to be able to load curcumin and biomacromolecules, either alone or in combination. Strategies for surface decoration with the employment of D-mannose as specific molecule to guarantee TAMs recognition were proposed. Finally, cytocompatibility of the amino-PVA and CSt stabilized NPs have been assessed.
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Yilgor, Pinar. "Sequential Growth Factor Delivery From Polymeric Scaffolds For Bone Tissue Engineering." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611188/index.pdf.

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Tissue engineering is a promising alternative strategy to produce artificial bone substitutes
however, the control of the cell organization and cell behavior to create fully functional 3-D constructs has not yet been achieved. To overcome these, activities have been concentrated on the development of multi-functional tissue engineering scaffolds capable of delivering the required bioactive agents to initiate and control cellular activities. The aim of this study was to prepare tissue engineered constructs composed of polymeric scaffolds seeded with mesenchymal stem cells (MSCs) carrying a nanoparticulate growth factor delivery system that would sequentially deliver the growth factors in order to mimic the natural bone healing process. To achieve this, BMP-2 and BMP-7, the osteogenic growth factors, were encapsulated in different polymeric nanocapsules (poly(lactic acid-co-glycolic acid) (PLGA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)) with different properties (degradation rates, crystallinity) and, therefore, different release rates to achieve the early release of BMP-2 followed by the release of BMP-7, as it is in nature. Initially, these nanoparticulate delivery systems were characterized and then the effect of single, simultaneous and sequential delivery of BMP-2 and BMP-7 from these delivery systems was studied in vitro using rat bone marrow MSCs. The effect of using these two growth factors in a sequential manner by mimicking their natural bioavailability timing was shown with maximized osteogenic activity results. BMP-2 loaded PLGA nanocapsules were subcutaneously implanted into Wistar rats and according to initial results, their biocompatibility as well as the positive effect of BMP-2 release on the formation of osteoclast-like cells was shown. To complete the construction of the bioactive scaffold, this nanoparticulate sequential delivery system was incorporated into two different types of polymeric systems
natural (chitosan) and synthetic (poly(&
#949
-caprolactone) (PCL)). 3-D fibrous scaffolds were produced using these materials by wet spinning and 3-D plotting. Incorporation of nanocapsules into 3-D chitosan scaffolds was studied by two different methods: incorporation within and onto chitosan fibers. Incorporation into 3-D PCL scaffolds was achieved by coating the nanocapsules onto the fibers of the scaffolds in an alginate layer. With both scaffold systems, incorporation of nanocapsule populations capable of delivering BMP-2 and BMP-7 in single, simultaneous and sequential fashion was achieved. As with free nanocapsules, the positive effect of sequential delivery on the osteogenic differentiation of MSCs was shown with both scaffold systems, creating multi-functional scaffolds capable of inducing bone healing.
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Quintanar-Guerrero, David. "Étude de nouvelles techniques d'obtention de suspensions de nanoparticules à partir de polymères préformés." Lyon 1, 1997. http://www.theses.fr/1997LYO1T270.

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Kaur, Jasmeet. "Properties of biologically relevant nanocomposites: effects of calcium phosphate nanoparticle attributes and biodegradable polymer morphology." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33981.

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This research is directed toward understanding the effect of nanoparticle attributes and polymer morphology on the properties of the nanocomposites with analogous nanoparticle chemistry. In order to develop this understanding, polymer nanocomposites containing calcium phosphate nanoparticles of different specific surface areas and shapes were fabricated and characterized through thermal and thermomechanical techniques. Nanoparticles were synthesized using reverse microemulsion technique. For nanocomposites with different surface area particles, the mobility of amorphous polymer chains was restricted significantly by the presence of particles with an interphase network morphology at higher loadings. Composites fabricated with different crystallinity matrices showed that the dispersion characteristics and reinforcement behavior of nanoparticles were governed by the amount of amorphous polymer fraction available. The study conducted on the effect of nanoparticle shape with near-spherical and nanofiber nanoparticles illustrated that the crystallization kinetics and the final microstructure of the composites was a function of shape of the nanoparticles. The results of this research indicate that nanoparticle geometry and matrix morphology are important parameters to be considered in designing and characterizing the structure-property relationship in polymer nanocomposites.
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Li, Yonghui. "Biodegradable poly(lactic acid) nanocomposites: synthesis and characterization." Diss., Kansas State University, 2011. http://hdl.handle.net/2097/8543.

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Doctor of Philosophy
Department of Grain Science and Industry
X. Susan Sun
Biobased polymers derived from renewable resources are increasingly important due to acute concerns about the environmental issues and limited petroleum resources. Poly(lactic acid) (PLA) is such a polymer that has shown great potential to produce biodegradable plastics. However, low glass transition temperature (Tg), low thermal stability, slow biodegradation rate, and high cost limit its broad applications. This dissertation seeks to overcome these limitations by reinforcing PLA with inorganic nanoparticles and low-cost agricultural residues. We first synthesized PLA nanocomposites by in situ melt polycondensation of L-lactic acid and surface-hydroxylized nanoparticles (MgO nanocrystals and TiO2 nanowires) and investigated the structure-property relationships. PLA grafted nanoparticles (PLA-g-MgO, PLA-g-TiO2) were isolated from the bulk nanocomposites via repeated dispersion/centrifugation processes. The covalent grafting of PLA chains onto nanoparticle surface was confirmed by Fourier transform infrared spectroscopy and thermalgravimetric analysis (TGA). Transmission electron microscopy and differential scanning calorimetry (DSC) results also sustained the presence of the third phase. Morphological images showed uniform dispersion of nanoparticles in the PLA matrix and demonstrated a strong interfacial interaction between them. Calculation based on TGA revealed that more than 42.5% PLA was successfully grafted into PLA-g-MgO and more than 30% was grafted into PLA-g-TiO2. Those grafted PLA chains exhibited significantly increased thermal stability. The Tg of PLA-g-TiO2 was improved by 7 °C compared with that of pure PLA. We also reinforced PLA with low-value agricultural residues, including wood flour (WF), soy flour (SF), and distillers dried grains with solubles (DDGS) by thermal blending. Tensile measurements and morphological images indicated that methylene diphenyl diisocyanate (MDI) was an effective coupling agent for PLA/WF and PLA/DDGS systems. MDI compatibilized PLA/WF and PLA/DDGS composites showed comparable tensile strength and elongation at break as pure PLA, with obviously increased Young’s modulus. Increased crystallinity was observed for PLA composites with SF and DDGS. Such PLA composites have similar or superior properties compared with pure PLA, especially at a lower cost and higher biodegradation rate than pure PLA. The results from this study are promising. These novel PLA thermoplastic composites with enhanced properties have potential for many applications, such as packaging materials, textiles, appliance components, autoparts, and medical implants.
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Nastiti, Christofori Maria Ratna Rini. "Development and evaluation of polymeric nanoparticle formulations for triamcinolone acetonide delivery." Thesis, Curtin University, 2007. http://hdl.handle.net/20.500.11937/613.

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The aims of this study were to develop polymeric NP formulations for triamcinolone acetonide (TA) delivery, from biodegradable and biocompatible hydrophobic polymers, which provide sustained release, prolonged stability and low toxicity, and to assess the toxicity of TA NPs (TA-NPs) compared to TA alone upon BALB/c 3T3 and ARPE 19 cell culture models.The study involved investigation of three different types of polymers: poly(D,L,lactide) (PDLLA), poly(D,L,lactide-co-glycolide)(PLGA) and methoxypolyethyleneglycol poly(D,L,lactide-co-glycolide)(mPEG PLGA). Two different methods were studied in the TA-NPs preparation: spontaneous emulsification solvent diffusion and emulsification solvent evaporation methods.The results show that emulsification-solvent evaporation method was superior to spontaneous emulsification solvent diffusion in terms of yield, loading and entrapment efficiency. TA-NPs synthesised of mPEG PLGA exhibited the smallest particle size, highest efficiency and fastest release of TA, whereas PDLLA produced large TA-NPs with the slowest TA release. The toxicity study revealed that BALB/c 3T3 was more sensitive than ARPE 19 and was concentration dependent in response to 24 hour exposure of either TA or TA-NPs, while ARPE 19 appeared to be less sensitive to the exposure. All NPs were less toxic than TA in all concentrations, in both cell models.
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Hawkins, Ashley Marie. "BIODEGRADABLE HYDROGELS AND NANOCOMPOSITE POLYMERS: SYNTHESIS AND CHARACTERIZATION FOR BIOMEDICAL APPLICATIONS." UKnowledge, 2012. http://uknowledge.uky.edu/cme_etds/10.

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Hydrogels are popular materials for biological applications since they exhibit properties like that of natural soft tissue and have tunable properties. Biodegradable hydrogels provide an added advantage in that they degrade in an aqueous environment thereby avoiding the need for removal after the useful lifetime. In this work, we investigated poly(β-amino ester) (PBAE) biodegradable hydrogel systems. To begin, the factors affecting the macromer synthesis procedure were studied to optimize the reproducibility of the resulting hydrogels made and create new methods of tuning the properties. Hydrogel behavior was then tuned by altering the hydrophilic/hydrophobic balance of the chemicals used in the synthesis to develop systems with linear and two-phase degradation profiles. The goal of the research was to better understand methods of controlling hydrogel properties to develop systems for several biomedical applications. Several systems with a range of properties were synthesized, and their in vitro behavior was characterized (degradation, mechanical properties, cellular response, etc.). From these studies, materials were chosen to serve as porogen materials and an outer matrix material to create a composite scaffold for tissue engineering. In most cases, a porous three dimensional scaffold is ideal for cellular growth and infiltration. In this work, a composite with a slow degrading outer matrix PBAE with fast degrading PBAE microparticles was created. First, a procedure for developing porogen particles of controlled size from a fast-degrading hydrogel material was developed. Porogen particles were then entrapped in the outer hydrogel matrix during polymerization. The resulting composite systems were degraded and the viability of these systems as tissue engineering scaffolds was studied. In a second area of work, two polymer systems, one PBAE hydrogel and one sol-gel material were altered through the addition of iron oxide nanoparticles to create materials with remote controlled properties. Iron oxide nanoparticles have the ability to heat in an alternating magnetic field due to the relaxation processes. The incorporation of these nanoscale heating sources into thermosensitive polymer systems allowed remote actuation of the physical properties. These materials would be ideal for use in applications where the system can be changed externally such as in remote controlled drug delivery.
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Books on the topic "Biodegradable polymeric nanoparticles"

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De, Arnab, Rituparna Bose, Ajeet Kumar, and Subho Mozumdar. Targeted Delivery of Pesticides Using Biodegradable Polymeric Nanoparticles. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1689-6.

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Springer. Targeted Delivery of Pesticides Using Biodegradable Polymeric Nanoparticles. Springer London, Limited, 2013.

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Bose, Rituparna, Arnab De, Ajeet Kumar, and Subho Mozumdar. Targeted Delivery of Pesticides Using Biodegradable Polymeric Nanoparticles. Springer, 2013.

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Wohlbier, Thomas. Nanohybrids. Materials Research Forum LLC, 2021. http://dx.doi.org/10.21741/9781644901076.

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The book covers preparation, designing and utilization of nanohybrid materials for biomedical applications. These materials can improve the effectiveness of drugs, promote high cell growth in new scaffolds, and lead to biodegradable surgical sutures. The use of hybrid magneto-plasmonic nanoparticles may lead to non-invasive therapies. The most promising materials are based on silica nanostructures, polymers, bioresorbable metals, liposomes, biopolymeric electrospun nanofibers, graphene, and gelatin. Much research focuses on the development of biomaterials for cell regeneration and wound healing applications.
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Book chapters on the topic "Biodegradable polymeric nanoparticles"

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Fattal, Elias, Hervé Hillaireau, Simona Mura, Julien Nicolas, and Nicolas Tsapis. "Targeted Delivery Using Biodegradable Polymeric Nanoparticles." In Fundamentals and Applications of Controlled Release Drug Delivery, 255–88. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0881-9_10.

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Kempe, Kristian, and Joseph A. Nicolazzo. "Biodegradable Polymeric Nanoparticles for Brain-Targeted Drug Delivery." In Neuromethods, 1–27. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0838-8_1.

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Das, Nandita G., and Sudip K. Das. "Development of Biodegradable Polymeric Nanoparticles for Systemic Delivery." In Healthy Ageing and Longevity, 155–86. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-54490-4_6.

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Sumana, M., A. Thirumurugan, P. Muthukumaran, and K. Anand. "Biodegradable Natural Polymeric Nanoparticles as Carrier for Drug Delivery." In Integrative Nanomedicine for New Therapies, 231–46. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36260-7_8.

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Akagi, Takami, Masanori Baba, and Mitsuru Akashi. "Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine." In Polymers in Nanomedicine, 31–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/12_2011_150.

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Fufă, Oana, Oana Fuf, George Mihail Vlăsceanu, Georgiana Dolete, Daniela Cabuzu, Rebecca Alexandra Puiu, Andreea Cîrjă, Bogdan Nicoară, and Alexandru Mihai Grumezescu. "Nanostructurated Composites Based on Biodegradable Polymers and Silver Nanoparticles." In Handbook of Composites from Renewable Materials, 585–621. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119441632.ch144.

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Debnath, Sujit Kumar, Barkha Singh, Nidhi Agrawal, and Rohit Srivastava. "EPR-Selective Biodegradable Polymer-Based Nanoparticles for Modulating ROS in the Management of Cervical Cancer." In Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 2863–89. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-5422-0_127.

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Debnath, Sujit Kumar, Barkha Singh, Nidhi Agrawal, and Rohit Srivastava. "EPR-Selective Biodegradable Polymer-Based Nanoparticles for Modulating ROS in the Management of Cervical Cancer." In Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 1–28. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-1247-3_127-1.

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Malviya, Neelesh, Sapna Malviya, Rajiv Saxena, Vishakha Chauhan, and Manisha Dhere. "Smart Biodegradable Polymeric Nanoparticles." In Advancements in Controlled Drug Delivery Systems, 257–80. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8908-3.ch011.

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Biodegradable polymers are defined as polymers that can be degraded by the micro-organism within a suitable period. Biodegradable polymers are degraded by enzymatic hydrolysis and oxidation to non-toxic small molecules, which can be metabolized by or excreted from the body. Biodegradable polymers and their degraded products do not cause any serious effects on the environment. Biodegradable polymers are also called smart biodegradable polymers because of their ability to respond to very slight changes in the surrounding environment. Smart biodegradable polymers have immense potential in drug delivery systems since they are able to release, at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers. Smart polymeric materials respond with a considerable change in their properties to small changes in their environment: environmental stimuli like temperature, pH, chemicals, and light. In this chapter, synthesis, characterization, and various applications of smart nanoparticles are summarized.
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Singh, Vijay Kumar, and Raj K. Keservani. "Application of Nanoparticles as a Drug Delivery System." In Pharmaceutical Sciences, 128–53. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1762-7.ch006.

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Small colloidal particles having their diameter in the range of 50 to 500nm are defined as Nanoparticles. These are usually prepared either by using biodegradable or non-biodegradable polymers and are usually classified in two broad categories: (1) Nanocapsules: a type of reservoir system in which an oil or aqueous core is surrounded by a polymeric membrane. (2) Nanospheres: a type of matrix system. Preparation of nanoparticle as a drug delivery system is one of the most widely accepted approach since the prepration of nanoparticle were easy and convenient to scale up. Their high stability and conveniently easy to freeze-dried their preparations provide some additional advantages to choose Nanoparticles as a good drug delivery system. Inspite of them Nanoparticles were were able to achieve with success tissue targeting of many drugs (antibiotics, cytostatics, peptides and proteins, nucleic acids, etc.).
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Conference papers on the topic "Biodegradable polymeric nanoparticles"

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Alquadeib, Bushra. "Encapsulation of Sertraline in Biodegradable Polymeric Nanoparticles." In The 9th World Congress on New Technologies. Avestia Publishing, 2023. http://dx.doi.org/10.11159/icepr23.132.

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Li, Wengang, and Qasim Sahu. "A Review: Progress of Diverter Technology for Oil and Gas Production Applications in the Past Decade." In Gas & Oil Technology Showcase and Conference. SPE, 2023. http://dx.doi.org/10.2118/214118-ms.

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Abstract Diversion technologies is becoming widely used as part of multistage fracturing operation and acid stimulation especially in carbonate formations completed with extended reach or multilateral wells. Further importance is gained during the development of unconventional resources where large number of stages are required with enhanced stimulated reservoir volume (SRV) per fracture. This is achieved by improving the fracture network and complexity using far field or deep diversion techniques. Diversion gained more value since it was an enabler for more efficient refracturing jobs since it can divert treatment from existing fractures. One of the main functions of diverters is to direct the stimulation fluid toward the desired treatment interval to increase the efficiency of productivity enhancement process. A diverter could be either mechanical or chemical. Mechanical diverters include packers, ball sealers, coil tubing, and particulate diverting agents such as benzoic acid flakes, rock salts, wax beads and fiber. Chemical diverter is mostly used as temporary barrier of fluid during treatments, and will get converted back afterwards by chemical means. Chemical diverter can be divided into two main types: polymer-based diverter and surfactant-based diverter. In the past decade, biodegradable diverter has been developed according to the concern of both environmental protection and less formation damage. Relative permeability modifier (RPM) can also be used as diverter in some cases. All the above diversion techniques will either divert the fluid in the wellbore or deep inside the formation based on the objective of the treatment and type of fluid used. This paper covers diverters in both injectors and producers with the applications of matrix acidizing, acid fracturing and hydraulic fracturing. In matrix acidizing, polymer-based acid gel is one of the most applied diverters. Adding N2/CO2 to form foamed acid, the treatment efficiency could be further enhanced with less formation damage. Viscoelastic surfactant (VES) improved acidizing was also applied in many cases. Fiber based acidizing fluid proposed to be effective in carbonate formation. Multi-stage acid frac jobs were done in 2011 in tight gas carbonate formations. A new trend of acid frac is to use CO2 energized fracturing fluid for tight, sour gas formations. Far-field fracturing mechanism was studied by means of solid particulate diverting agents. Eco-friendly and biodegradable diverters were applied for zonal isolation. Nanoparticles, as new generation of diverters, have been used for EOR as foaming agents since beginning of this decade, especially at HTHP conditions; nanoparticle stabilizers were applied in polymeric gel and VES system to enhance the stability for diversion fluid. To make the best performance of diverters, limitation on working conditions of each type of diverter would be identified, such as cost, temperature range, pH range, size distribution, and compatibility with fluid additives.
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Zhu, Ming-Qiang, Guo-Feng Zhang, Zhe Hu, Wen-Liang Gong, Matthew P. Aldred, and Zhen-Li Huang. "Biodegradable polymer nanoparticles with photoswitchable fluorescence for super-resolution bioimaging." In Novel Techniques in Microscopy. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/ntm.2013.nm2b.7.

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Saha, Debasish, Apoorva Agarwal, Jaydeep Bhattacharya, Debes Ray, Vinod K. Aswal, and Joachim Kohlbrecher. "The role of solvent in the formation of biodegradable polymer nanoparticles." In DAE SOLID STATE PHYSICS SYMPOSIUM 2018. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5112880.

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Aykaç, Ahmet, and İzel Ok. "Investigations and Concerns about the Fate of Transgenic DNA and Protein in Livestock." In International Students Science Congress. Izmir International Guest Student Association, 2021. http://dx.doi.org/10.52460/issc.2021.046.

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Hydrogels are biocompatible and swollen materials that have been used as a wound dressing for years. Among them, chitosan-based hydrogels have become popular in the wound healing process owing to their low toxic, biocompatible, biodegradable, antibacterial properties. Chitosan (CS) has been used either as a pure form or incorporated with polymers or nanoparticles to increase antimicrobial activity and stability. In this context, zinc oxide nanoparticles (ZnO NPs) have been used to enhance antibacterial activity and mesoporous silica nanoparticles (MSN) have been employed to develop mechanical strength and control of drug release time. In this study, we report the synthesis and fully characterizations of ZnO NPs, MSN and the hydrogel by using dynamic light scattering (DLS), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR). We have also prepared and characterized chitosan-based hydrogels functionalized by MSNs and ZnO NPs.
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Asmatulu, R., A. Garikapati, H. E. Misak, Z. Song, S. Y. Yang, and P. Wooley. "Cytotoxicity of Magnetic Nanocomposite Spheres for Possible Drug Delivery Systems." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-40269.

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Cytotoxicity test is a rapid and standardized in vitro method to determine the harmful effects of materials used for biomedical purposes, such as drug carriers, implants and their coatings, biosensors and surgical/medical devices. In the present study, sol-gel driven nickel ferrite (NiFe2O4) and cobalt ferrite (CoFe2O4) nanoparticles (10–25 nm) at different concentrations were incorporated into biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), using oil-in-oil emulsion/solvent evaporation technique, and then the cytotoxicity of magnetic nanocomposite spheres was characterized using raw cells. The test provides the toxicity of the products prior to their real applications, which may limit animal experimentation, remove potential toxic compounds and reduce the downstream costs. The cytotoxicity results showed that both magnetic nanocomposite spheres were toxic at some degree to the raw cells; however, the cobalt ferrite nanoparticles in nanocomposite spheres are more toxic than the nickel ferrite nanoparticles.
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Sandri, Monica, Michele Iafisco, Silvia Panseri, Elisa Savini, and Anna Tampieri. "Fully Biodegradable Magnetic Micro-Nanoparticles: A New Platform for Tissue Regeneration and Theranostic." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93223.

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Nowadays, magnetic materials are receiving special attention due to their potential applications in different fields and in particular in medicine. Magnetic micro-nano-particles have been progressively employed as support materials for enzyme immobilization, and have been used as drug-delivery vehicles, contrast agents for magnetic resonance imaging as well as heat mediators for hyperthermia-based anti-cancer treatments and many other exciting biomedical applications. Magnetic materials have also attracted a big interest in the field of bone tissue regeneration because it has been demonstrated that magnetic nanoparticles have effect of osteoinduction even without external magnetic force. Therefore, one of the most big challenge in this field is the production of magnetic materials with good biocompatibility and biodegradability. In fact, the long-term effects in the human body of iron oxide (maghemite or magnetite), the most popular magnetic phase used in medicine and biotechnology, are not yet completely assessed. To this aim, in this work we developed an innovative biocompatible and bioresorbable superparamagnetic-like phase by doping nano-hydroxyapatite with Fe2+/Fe3+ ions (FeHA). Moreover the same magnetic nanoparticles were used as nano-particulate emulsifier for the preparation of hollow hybrid Fe-HA-poly(L-lactic) acid (PLLA) micro-nano-spheres. PLLA has been used because poly(α-hydroxy-esters) are the most frequently used synthetic polymers for biomedical applications owing to their biocompatibility, hydrolytic degradation process and proper mechanical properties. These micro-nanospheres could be used as new type of scaffold for hard tissue regeneration. In fact, spherical scaffold display several advantages respect to the monolithic counterpart e.g., (i) improving control over sustained delivery of therapeutic agents, signalling biomolecules and even pluripotent stem cells, (ii) serving as stimulus-sensitive delivery vehicles for triggered release, (iii) introducing porosity and/or improve the mechanical properties of bulk scaffolds by acting as porogen or reinforcement phase, (iv) supplying compartmentalized micro-reactors for dedicated biochemical processes, (v) functioning as cell delivery vehicle, and, finally, (vi) giving possibility of preparing injectable and/or mouldable formulations to be applied by using minimally invasive surgery. Moreover, the same magnetic materials could find applications in nanomedicine as a multifunctional carrier. Their magnetic functionality could be utilized to move them into the body towards target organs by an external magnetic field. Furthermore, the superparamagnetic feature of the nanoparticles could allow to tailor the release of the therapeutic agent by switching (on-off) the external magnetic field and/or to treat cancer cells by hyperthermia.
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Yeo, Leslie Y., and James R. Friend. "Surface Acoustic Waves: A New Paradigm for Driving Ultrafast Biomicrofluidics." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18517.

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Surface acoustic waves (SAWs), which are 10 MHz order surface waves roughly 10 nm in amplitude propagating on the surface of a piezoelectric substrate, can offer a powerful method for driving fast microfluidic actuation and microparticle or biomolecule manipulation. We demonstrate that sessile drops can be linearly translated on planar substrates or fluid can be pumped through microchannels at typically one to two orders of magnitude faster than that achievable through current microfluidic technologies. Micromixing can be induced in the same microchannel in which fluid is pumped using the SAW simply by changing the SAW frequency to superimpose a chaotic oscillatory flow onto the uniform through flow. Strong inertial microcentrifugation for micromixing and particle concentration or separation can also be induced via symmetry-breaking. At low SAW amplitudes below that at which flow commences, the transverse standing wave that arises across the microchannel afford particle aggregation and hence sorting on nodal lines. Other microfluidic manipulations are also possible with the SAW. For example, capillary waves excited on a sessile drop by the SAW can be exploited for microparticle or nanoparticle collection and sorting. At higher amplitudes, the large substrate accelerations drives rapid destabilization of the drop interface giving rise to inertial liquid jets or atomization to produce 1–10 μm monodispersed aerosol droplets. These have significant implications for microfluidic chip mass spectrometry interfacing or pulmonary drug delivery. The atomization also provides a convenient means for the synthesis of 150–200 nm polymer or protein particles or to encapsulate proteins, peptides and other therapeutic molecules within biodegradable polymeric shells for controlled release drug delivery. The atomization of thin films containing polymer solutions, in addition, gives produces a unique regular, long-range spatial polymer spot patterning effect whose size and spacing are dependent on the SAW frequency, thus offering a simple and powerful method for surface patterning without requiring physical or chemical templating.
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Krasnoshtanova, Alla, and Anastasiya Bezyeva. "DETERMINATION OF THE OPTIMAL CONCENTRATIONS OF PECTIN AND CALCIUM CHLORIDE FOR THE SYNTHESIS OF CHITOSAN-PECTIN MICROPARTICLES." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b1/v3/09.

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"The oral route of drug inclusion is the most convenient for the patient. In addition to ease of use, this method of drug inclusion has such advantages as non-invasiveness of inclusion, absence of complications during injection; comparative safety for the organism due to the passage of the active substance and auxiliary compounds through the gastrointestinal tract; the possibility of introducing larger doses of the drug at one time. However, despite the obvious advantages, the oral route of inclusion has a number of significant disadvantages that significantly limit its use for a number of drugs. Among them are: relatively slow therapeutic action of the drug with this route of inclusion; the aggressive effect of a number of drugs (for example, antibiotics) on the gastrointestinal tract; low bioavailability of a number of substances (especially high molecular weight hydrophilic compounds), caused by poor permeability of the intestinal epithelium for hydrophilic and large molecules, as well as enzymatic and chemical degradation of the active substance in the gastrointestinal tract. There are various approaches used in the development of oral drug delivery systems. In particular, for the targeted delivery of drugs, it is proposed to use nano- and microcapsules with mucoadhesive properties. Among the polymers used for the synthesis of these microparticles, it is preferable to use pH-dependent, gelable biopolymers that change their structure depending on the acidity of the environment. Microcapsules obtained from compounds with the above properties are capable of protecting the active substance (or from the active substance) in the stomach environment and ensuring its release in the intestine. These properties are possessed by such polysaccharides as alginate, pectin, carrageenan, xylan, etc. The listed biopolymers are non-toxic, biocompatible, and biodegradable, which makes microparticles containing these polysaccharides promising as oral drug delivery systems. To impart mucoadhesive properties to nanoparticles, complexes of the listed polymers with chitosan are used. In this research, pectin, a polysaccharide formed mainly by residues of galacturonic acid, was used as a structural polymer. The concentrations of substances in the initial solutions were selected that were optimal for the synthesis of microcapsules. The main parameters for evaluating the resulting microparticles were the size of the capsules (less than 1 μm for oral inclusion), the zeta-potential, showing the tendency of the microparticles to stick together, and the completeness of the binding of the microparticles to chitosan. It was found that the optimal solutions for the synthesis of microparticles are: 15.7 ml of a solution of pectin 0.093% by weight, 3.3 ml of a solution of chitosan 0.07% by weight and 1.0 ml of a solution of CaCl2 20 mM. The diameter of the microparticles obtained by this method was 700-800 nm, and the value of their zetta-potential, equal to - (34 ± 3) mV, does not cross the particle adhesion threshold. It was also found that the synthesis of microparticles at these concentrations of calcium chloride provides the most complete binding of chitosan to their surface, which increases the mucoadhesive properties of microparticles."
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