Relevant bibliographies by topics / Biochemistry and Cell Biology

Academic literature on the topic 'Biochemistry and Cell Biology'

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Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Biochemistry and Cell Biology"

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BURRIDGE, K., and L. MOLONY. "Talin: Biochemistry and Cell Biology." Advances in Molecular and Cell Biology 3 (1990): 95–109. http://dx.doi.org/10.1016/s1569-2558(08)60445-2.

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Luzio, J. P. "Cell Biology (Molecular and Cell Biochemistry Series)." Trends in Genetics 8, no. 7 (July 1992): 258. http://dx.doi.org/10.1016/0168-9525(92)90401-o.

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RASMUSSEN, N. "Cell fractionation biochemistry and the origins of ?cell biology?" Trends in Biochemical Sciences 21, no. 8 (August 1996): 319–21. http://dx.doi.org/10.1016/0968-0004(96)10041-4.

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Holst, Otto, Artur J. Ulmer, Helmut Brade, Hans-Dieter Flad, and Ernst Th Rietschel. "Biochemistry and cell biology of bacterial endotoxins." FEMS Immunology & Medical Microbiology 16, no. 2 (December 1996): 83–104. http://dx.doi.org/10.1111/j.1574-695x.1996.tb00126.x.

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McDevitt, Cahir A., and Raymond R. Miller. "Biochemistry, cell biology, and immunology of osteoarthritis." Current Opinion in Rheumatology 1, no. 3 (October 1989): 303–14. http://dx.doi.org/10.1097/00002281-198901030-00011.

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Artus, Nancy N., Shauna C. Somerville, Christopher R. Somerville, and George H. Lorimer. "The biochemistry and cell biology of photorespiration." Critical Reviews in Plant Sciences 4, no. 2 (January 1986): 121–47. http://dx.doi.org/10.1080/07352688609382221.

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Ishii, Eiichi, and Shaw Watanabe. "Biochemistry and Biology of the Langerhans Cell." Hematology/Oncology Clinics of North America 1, no. 1 (March 1987): 99–118. http://dx.doi.org/10.1016/s0889-8588(18)30688-9.

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Hofius, Daniel, and Uwe Sonnewald. "Vitamin E biosynthesis: biochemistry meets cell biology." Trends in Plant Science 8, no. 1 (January 2003): 6–8. http://dx.doi.org/10.1016/s1360-1385(02)00002-x.

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Sabatini, David D. "Philip Siekevitz: Bridging biochemistry and cell biology." Journal of Cell Biology 189, no. 1 (March 29, 2010): 3–5. http://dx.doi.org/10.1083/jcb.201002147.

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Philip Siekevitz, an Emeritus Professor at the Rockefeller University who made pioneering contributions to the development of modern cell biology, passed away on December 5th, 2009. He was a creative and enthusiastic scientist, as well as a great experimentalist who throughout his lifetime transmitted the joy of practicing science and the happiness that comes with the acquisition of new knowledge. He was a man of great integrity, with a thoroughly engaging personality and a humility not often found in people of his talent.
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Figon, Florent, and Jérôme Casas. "Ommochromes in invertebrates: biochemistry and cell biology." Biological Reviews 94, no. 1 (July 10, 2018): 156–83. http://dx.doi.org/10.1111/brv.12441.

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Dissertations / Theses on the topic "Biochemistry and Cell Biology"

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Camacho, Diogo Mayo. "In silico cell biology and biochemistry: a systems biology approach." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/27960.

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In the post-"omic" era the analysis of high-throughput data is regarded as one of the major challenges faced by researchers. One focus of this data analysis is uncovering biological network topologies and dynamics. It is believed that this kind of research will allow the development of new mathematical models of biological systems as well as aid in the improvement of already existing ones. The work that is presented in this dissertation addresses the problem of the analysis of highly complex data sets with the aim of developing a methodology that will enable the reconstruction of a biological network from time series data through an iterative process. The first part of this dissertation relates to the analysis of existing methodologies that aim at inferring network structures from experimental data. This spans the use of statistical tools such as correlations analysis (presented in Chapter 2) to more complex mathematical frameworks (presented in Chapter 3). A novel methodology that focuses on the inference of biological networks from time series data by least squares fitting will then be introduced. Using a set of carefully designed inference rules one can gain important information about the system which can aid in the inference process. The application of the method to a data set from the response of the yeast Saccharomyces cerevisiae to cumene hydroperoxide is explored in Chapter 5. The results show that this method can be used to generate a coarse-level mathematical model of the biological system at hand. Possible developments of this method are discussed in Chapter 6.
Ph. D.
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Agüera-González, Sonia. "Cell biology on NKG2D ligands and NK cell recognition." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609348.

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Chambers, Jeremy W. "Studies in the biochemistry and cell biology of Trypanosoma brucei hexokinases." Connect to this title online, 2007. http://etd.lib.clemson.edu/documents/1202500780/.

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Trotman, Jackson B. "New Insights into the Biochemistry and Cell Biology of RNA Recapping." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523896565730483.

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Delorme, Marilyne. "Downregulation of ATRX disrupts cell proliferation and cell cycle progression." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27627.

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ATRX is a chromatin remodelling protein of the SNF2 family of chromatin remodelling proteins. Mutations in the ATRX gene have been shown to cause the ATR-X syndrome, an X-linked mental retardation disorder. ATRX is part of a chromatin-remodelling complex with Daxx that localizes to PML nuclear bodies or pericentromeric heterochromatin and is thought to regulate gene expression. In mice, Atrx inactivation results in embryonic lethality whereas conditional forebrain specific Atrx ablation showed impaired development and disorganization of the cortex. Furthermore, ATRX phosphorylation was shown to be cell cycle dependant, suggesting an important role for ATRX in cell cycle regulation. In this study we investigated the effects of ATRX downregulation in cell culture models, using siRNA transient transfection, a clone expressing an shRNA targeted to ATRX, and Atrxnull MEFs. ATRX downregulated cells showed reduced growth rates and cell cycle defects at the G1 and S phases of the cell cycle. Moreover, ATRX ablation was associated with an altered Rb phosphorylation status and decreased expression of the cyclin A and E2F-1 proteins. Taken together our results suggest that ATRX may play a significant role in cell cycle progression that is pertinent for proper development.
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Hussey, P. J. "Studies on the molecular and cell biology of plant tubulin." Thesis, University of Kent, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376791.

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Ye, Qing. "LIPASE-KINASE ASSOCIATIONS INVOLVING PLD2, JAK3 AND FES THAT UNDERLIE CANCER CELL PROLIFERATION AND INVASION." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1421939242.

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Chu, Wei. "Mouse Mast Cell Proteases: Induction, Molecular Cloning, and Characterization." Digital Commons @ East Tennessee State University, 1991. https://dc.etsu.edu/etd/2656.

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Tryptase, a mast cell-specific serine protease with trypsin-like specificity, has been identified in a mouse mast cell line (ABFTL-6) based on it's enzymatic activity, inhibition properties, and cross-reactivity to a human mast cell tryptase antibody. The effects of fibroblast-conditioned medium and sodium butyrate on ABFTL-6 mast cell differentiation and tryptase expression have been examined. ABFTL-6 mouse mast cells undergo phenotypic changes upon culturing in media supplemented with fibroblast-conditioned media at 50% or 1 mM sodium butyrate. The induced cells increased in size, had larger and more metachromatic cytoplasmic granules, and increased their total cellular protein about four-fold. Tryptase activity increased 13- and 6-fold upon fibroblast-conditioned media and butyrate induction, respectively. However, tryptase antigen levels increased dramatically from 2.3 $\mu$g/10$\sp6$ uninduced cells to 125 (54-fold) and 75 (33-fold) $\mu$g/10$\sp6$ cells induced with fibroblast-conditioned media or butyrate, respectively. A cDNA library was constructed in $\lambda$gt10 from ABFTL-6 cell poly(A)$\sp+$ RNA, and screened with dog mast cell tryptase and rat mast cell chymase cDNAs. Clones encoding two distinct tryptases (mouse tryptases I and II), a chymase (mouse chymase I) and a novel carboxyl terminal chymase (mouse chymase II) were isolated and sequenced. Mouse tryptases I and II have 75% and 70% sequence identity at the nucleotide and amino acid levels, respectively. The deduced amino acid sequence for the mature active enzyme for each mouse tryptase contains 245 residues and all the characteristics of a serine protease. Asp is found in the substrate binding pockets, consistent with a trypsin-like specificity for Arg-X and Lys-X bonds. It is predicted that tryptases are synthesized with prepropeptides, requiring signal peptidase processing and removal of a three amino acid propeptide for activation. Mouse chymase I consists of a 226 amino acid catalytic portion and a 21 amino acid preprosequence. An Asn occurs in the substrate binding pocket, a feature that has not been observed in any other serine protease.
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Petosa, Adamo. "Isolation of human scFv expressing cells from a yeast library using magnetic and fluorescence activated cell sorting." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101733.

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The effective and efficient generation of both antibodies and antibody fragments to proteins of interest is vital, as antibodies and antibody fragments are required for an ever-increasing variety of therapeutic, diagnostic and analytical applications. The single chain variable fragment (scFv) is an antibody fragment consisting of a heavy chain variable region (VH) and a light chain variable region (VL) joined together by a flexible polypeptide linker. In 2003, Feldhaus et al. developed a nonimmune human scFv surface display library, in Saccharomyces cerevisiae , containing 109 different scFvs. Cells in the library expressing scFvs of interest can be isolated using magnetic cell sorting (MCS) and fluorescence activated cell sorting (FACS).
The reduced size of the scFv relative to the intact IgG allows it to penetrate tissue with greater ease and therefore reach epitopes within both tissue and cells that would otherwise remain inaccessible. As a result, one possible scFv application is the study of cartilage destruction by proteases that occurs in both normal joint development and arthritis. Antibody fragments would allow for cartilage degradative processes to be studied in vivo . Fluorescently tagged scFvs could penetrate intact cartilage tissue, bind to epitopes and then be localized using techniques such as dual photon confocal microscopy. This would not be possible using IgG molecules.
The yeast library developed by Feldhaus et al. was obtained for the potential isolation of cells expressing scFvs to cartilage neoepitopes. While found to possess an inherent Candida parapsilosis contamination, the surface display library was screened using three peptide-ovalbumin-biotin complexes. Peptides corresponding to observed cartilage neoepitopes were bound to biotinylated ovalbumin and added to the library for screening. Excess unlabelled ovalbumin was also added to the library to prevent the isolation of ovalbumin binding cells.
In all, two rounds of MCS and two rounds of FACS with all three antigens were used to screen the library for binders. A portion of the remaining library cells was then screened by MCS with a single antigen and eight individual clones were isolated. The affinity of these clones was determined and the scFv region of one clone was sequenced. Despite preventative measures, all eight clones isolated and analyzed were found to have an affinity to undetermined ovalbumin complex regions other than the peptides of interest. Still, cells expressing scFvs binding to a portion of the antigen complexes presented to the library were clearly enriched and subsequently isolated using MCS and FACS.
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Bainor, Anthony J. "Elucidating the Role of SIN3B as a Regulator of Cell Cycle Exit." Thesis, New York University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10604607.

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Progression through the mammalian cell cycle is a tightly regulated process that allows cells to replicate their genomes and divide properly. In growth factor-deprived conditions or in response to stress, the cell will exit the cell cycle either reversibly through quiescence, or permanently via senescence. Studies have shown that the SIN3 family of proteins plays a crucial role in these cell cycle exit processes. SIN3 proteins are highly conserved, and exist in mammals as two family members: SIN3A and SIN3B, which function as flexible scaffolding proteins to assemble co-repressor complexes. Our laboratory has recently implicated SIN3B as a critical mediator of each of these cell cycle exit processes. However, its mechanism of action and the consequences of its disruption pertaining to cancer progression have not been comprehensively elucidated. Here we demonstrate that SIN3B is required for the induction of senescence in a mouse model of prostate cancer, and thus prevents the progression to aggressive and invasive carcinoma. In addition, through interaction analysis, we uncovered a novel and robust association between SIN3B and the DREAM complex. The DREAM complex, comprised of p107/p130, E2F4/5, DP1 and the MuvB core complex, is responsible for the repression of hundreds of cell cycle-related transcripts during quiescence. We determined that the deletion of SIN3B resulted in the derepression of DREAM target genes during quiescence, but was not sufficient to allow quiescent cells to resume proliferation. However, the ectopic expression of APC/CCDH1 inhibitor EMI1 was sufficient for SIN3B deleted cells, but not wild-type cells, to reenter the cell cycle. These studies demonstrate a critical role for SIN3B in the senescence and quiescence programs, and provide important mechanistic insight into the molecular pathways that exquisitely regulate cell cycle exit.

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Books on the topic "Biochemistry and Cell Biology"

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Lyn, Shepherd, and Allan Richard 1954-, eds. Cell biology & biochemistry. Hamilton, N.Z: Biozone International, 2006.

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Estes, James E. Actin: Biophysics, Biochemistry, and Cell Biology. Boston, MA: Springer US, 1994.

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Schwartzbach, Steven D., and Shigeru Shigeoka, eds. Euglena: Biochemistry, Cell and Molecular Biology. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-54910-1.

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Kreitzer, Geri, Fanny Jaulin, and Cedric Espenel. Cell biology assays: Proteins. Amsterdam: Elsevier/Academic Press, 2010.

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A, Cogoli, ed. Cell biology and biotechnology in space. Amsterdam: Elsevier, 2002.

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Bruce, Alberts, ed. Essential cell biology. 3rd ed. New York: Garland Science, 2009.

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Bruce, Alberts, ed. Essential cell biology. 2nd ed. New York, NY: Garland Science Pub., 2004.

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Bruce, Alberts, ed. Essential cell biology. Abingdon: Garland Science Pub., 1997.

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Rosann, Tung, ed. Essential cell biology test bank. New York: Garland Pub., 1997.

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An-Ping, Zeng, and SpringerLink (Online service), eds. Genomics and Systems Biology of Mammalian Cell Culture. 2nd ed. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012.

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Book chapters on the topic "Biochemistry and Cell Biology"

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Rodríguez, E. M. "Cell Biology and Biochemistry." In The Subcommissural Organ, 309–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78013-4_32.

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Severs, Nicholas J. "Cholesterol Cytochemistry in Cell Biology and Disease." In Subcellular Biochemistry, 477–505. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5901-6_16.

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Chan, Edmond Y. W., Robert Köchl, and Sharon A. Tooze. "Cell Biology and Biochemistry of Autophagy." In Autophagy in Immunity and Infection, 19–53. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/352760880x.ch2.

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Stewart, A. K., I. D. Dubé, and R. G. Hawley. "Gene Marking and the Biology of Hematopoietic Cell Transfer in Human Clinical Trials." In Blood Cell Biochemistry, 243–68. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4889-8_9.

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Hussain, Mahboob Ul. "General Cell Biology of Connexins." In SpringerBriefs in Biochemistry and Molecular Biology, 7–9. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1919-4_4.

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Suzuki, K., G. van Echten-Deckert, A. Klein, and K. Sandhoff. "Glycosphingolipids and sphingolipid activator proteins: Cell biology, biochemistry and molecular genetics." In Biochemistry of Cell Membranes, 137–49. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-9057-1_10.

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Roncero, Cesar, Alberto Sanchez-Diaz, and M. Henar Valdivieso. "9 Chitin Synthesis and Fungal Cell Morphogenesis." In Biochemistry and Molecular Biology, 167–90. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27790-5_9.

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Harrison, Michael A., and Steven P. Muench. "The Vacuolar ATPase – A Nano-scale Motor That Drives Cell Biology." In Subcellular Biochemistry, 409–59. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7757-9_14.

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Lee, Mark J., and Donald C. Sheppard. "8 The Cell Wall Polysaccharides of Aspergillus fumigatus." In Biochemistry and Molecular Biology, 147–65. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27790-5_8.

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Osborne, Daphne J. "Signals for Cell Separation in Plants Physiology, Biochemistry and Molecular Biology." In Cell to Cell Signals in Plants and Animals, 91–95. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76470-7_7.

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Conference papers on the topic "Biochemistry and Cell Biology"

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Schleuning, W. D. "THE BIOCHEMISTRY AND CELL BIOLOGY OF SINGLE CHAIN UROKINASE TYPE PLASMINOGEN ACTIVATOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642956.

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Urokinase was discovered in the late nineteenth century, as an enzymatic principle in urine, that initiates the dissolution of blood clots. The basis of this phenomenon was recognized more than fifty years ago as the activation of plasminogen, the precursor of a tryptic protease, then known as profibrinolysin. Despite this long history, detailed data on the biochemistry of plasminogen activation have only become available recently. Urokinase (now designated urokinase-type plasminogen activator : u-PA) is synthesized and secreted as a single chain polypeptide (Mr-: 53,000) by many cell types. Single chain u-PA (scu-PA) is with equal justification called prourokinase (pro-u-PA), notwithstanding its low catalytic activity for synthetic peptide substrates and plasminogen, as most proenzymes of proteases display a certain degree of activity. The structure of pro-u-PA has been elucidated by protein and cDNA sequencing. It consists of three domains, exhibiting characteristic homology to other proteins: a serine protease domain, homologous to trypsin, chymotrypsin and elastase; a kringle domain, likewise found in prothrombin, plasminogen, tissue-type plasminogen activator (t-PA) and Factor XII; and an epidermal growth factor (EGF)-like domain, found in many other proteins, including certain clotting factors. Pro-u-PA is activated by the cleavage of its LYS158-Ile159 h1 bY either plasmin or kallikrein. This cleavage leads to a high increase of Kcat values with respect to both plasminogen and synthetic peptide substrates, but apparently to a reduction of its affinity to plasminogen. Thrartoin inactivates pro-u-PA irreversibly by the cleavage of the Arg156-Phe157 bond. U-PA but not pro-u-PA rapidly forms ccnplexes with plasminogen activator inhibitors (PAI)-l and PAI-2: second order rate constants Kass are respectively > 107 and 0.9xl06 (M-11sec-1). Unknown enzymes process pro-u-PA and u-PA to low molecular weight (LMW) pro-u-PA and LMW u-PA (Mr: 33,000) by cutting off a fragment consisting of the kr ingle and the EGF—like region. Pro—u—PA mediated plasminogen activation is fibrin dependent in vivo, and to a certain degree in vitro. Hie biochemical basis of this fibrin specificity is at present uncertain, although there are reports indicating that it may require polyvalent cations. Through its EGF-like region HMW pro-u-PA and HMW u-PA are capable of binding to specific membrane protein receptors which are found on many cells. Thus, u-PA activity may be restricted to the cell surface. According to a recent report, binding of u—PA to the receptor may also mediate signal transduction in auto- or paracrine growth control. In cells permissive for the respective pathways, pro-u-PA gene transcription is stimulated by mechanisms of signal transduction, that include the cAMP, the tyrosine specific kinase and the protein kinase C dependent pathways. Glucocorticoid hormones downregulate pro-u-PA gene transcription in cells where the gene is canstitutively expressed. Although different cells vary greatly in their response to agents that stimulate urokinase biosynthesis, growth factors and other mitogens are in many cases effective inducers. Significantly elevated levels of u-PA are also found in many malignant tissues. These findings and many others suggest that plasminogen activation by u-PA provides localized extracellular matrix degradation which is required for invasive growth, cell migration and other forms of tissue remodelling. Fibrin represents in this view only a variant of an extracellular matrix, which is provided through the clotting system in the case of an emergency.
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LeDuc, Philip. "Linking Molecular to Cellular Biomechanics With Nano- and Micro-Technology." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43987.

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The link between mechanics and biochemistry has been implicated in a myriad of scientific and medical problem, from orthopedics and cardiovascular medicine, to cell motility and division, to signal transduction and gene expression. Most of these studies have been focused on organ-level issues, yet cellular and molecular level research has become essential over the last decade in this field thanks to the revolutionary developments in genetics, molecular biology, fabrication processes, and biotechnology. Developing the link between molecular and cellular biomechanics through subcellular studies can help uncover the complex interactions requisite for understanding higher order macroscopic behavior. Here, we will explore the link between molecular and cellular research through novel systems of nano- and micro-technology. In this, I will discuss novel technologies that we have developed and are utilizing, which include magnetic needles, three-dimension cell stretching systems, and microfluidics to examine the link between mechanics and biochemistry (including structural regulation through the cytoskeleton). By combining these novel approaches between engineering and biology, this multidisciplinary research can make a tremendous impact on the studies of human health and diseases through advances in fields such as proteomics, tissue engineering, and medical diagnostics.
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Wechsler, Marissa E., Courtney M. Creecy, Christine F. O’Neill, and Rena Bizios. "Effects of Electrical Stimulation on Select Functions of Bone Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80367.

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The present in vitro study was motivated by scientific literature reports that show enhanced healing of bone fractures in experimental animals in response to electrical stimulation. The underlying cellular- and molecular level mechanisms responsible for new bone formation, however, were not studied at that time. Since then, advances in cell biology, biochemistry and biomedical engineering provided knowledge, models, and instrumentation to investigate these unanswered questions.
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Young, Paul W. "Student-produced video of role-plays on topics in cell biology and biochemistry: A novel undergraduate group work exercise." In Learning Connections 2019: Spaces, People, Practice. University College Cork||National Forum for the Enhancement of Teaching and Learning in Higher Education, 2019. http://dx.doi.org/10.33178/lc2019.15.

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Group work or cooperative learning is a form of active learning that has potential benefits that extend beyond just being an alternative or improved way of learning course material. For example, Shimazoe and Aldrich (2010) identified six proposed benefits of active learning to students, namely (1) promoting deep learning, (2) helping students earn higher grades, (3) teaching social skills & civic values, (4) teaching higher order thinking skills, (5) promoting personal growth and (6) developing positive attitudes toward autonomous learning. There is evidence for the effectiveness of role-plays both in achieving learning outcomes (Azman, Musa, & Mydin, 2018; Craciun, 2010; Latif, Mumtaz, Mumtaz, & Hussain, 2018; McSharry & Jones, 2000; Yang, Kim, & Noh, 2010), but also in developing desirable graduate attributes such as teamwork, communication and problem solving skills [4]. The importance of such skills is widely touted by employers of science graduates, sometimes more so than discipline-specific knowledge, arguing in favour of the incorporation of role-plays and other forms of cooperative learning into undergraduate science curricula. Role-playing is probably not as widely used in the physical and life sciences as it is in other academic disciplines. In science the most obvious role-play scenarios in which students play the roles of people might be in examining historical figures at the centre of famous scientific discoveries or debates (Odegaard, 2003). In addition, role-plays fit well at the interface between science and other discipline when exploring ethical, legal or commercial implications of scientific discoveries(Chuck, 2011). However, to apply role-play to core topics in science or mathematics the roles that must be played are not those of people but rather of things like particles, forces, elements, atoms, numbers, laws, equations, molecules, cells, organs and so on. The learning scenarios for science-based roleplays in which the characters represented are not people are less obvious, probably explaining why the use of role-plays in science education is less common. Nevertheless, focusing on the life sciences, role-plays in which the characters are organelles in a cell or enzymes involved in fundamental cellular processes like DNA replication, RNA transcription and protein translation have been described for example (Cherif, Siuda, Dianne M. Jedlicka, & Movahedzadeh, 2016; Takemura & Kurabayashi, 2014). The communication of discipline-specific templates and successful models for the application of role-playing in science education is likely to encourage their wider adoption. Here I describe a videoed group role-play assignment that has been developed over a ten-year period of reflective teaching practice. I suggest that this model of videoed group role-plays is a useful cooperative learning format that will allow learners to apply their varied creativity and talents to exploring and explaining diverse scientific topics while simultaneously developing their teamwork skills.
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Kaksis, Aris, Agnese Brangule, and Mihails Halitovs. "AN APPROACH TO TEACHING MEDICAL CHEMISTRY THAT HIGHLIGHTS INTERDISCIPLINARY NATURE OF SCIENCE." In 1st International Baltic Symposium on Science and Technology Education. Scientia Socialis Ltd., 2015. http://dx.doi.org/10.33225/balticste/2015.54.

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Thermodynamics is a branch of physics that deals with questions concerning energies and work of a system. It is one of the key topics for understanding processes in the universe as well as any separate system like a gas mixture or a single cell in a biological system. Thermodynamics is included in the university curriculum for engineering, chemistry and physics students as well as medical student curriculum. This paper outlines the problems faced by first year medical students learning thermodynamics at Riga Stradinš University. We describe a medically relevant context based approach to teaching that demonstrates the interdisciplinary nature of medical chemistry, molecular biology and biochemistry. Our method provides a model in which disciplinary barriers are diminished and increased effectiveness of teaching is achieved. Key words: interdisciplinary teaching, medical chemistry, thermodynamics, teaching and learning thermodynamics.
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Souchelnytskyi, Serhiy. "Systemic properties of Carcinogenesis: Lessons from studies on the Earth and in the Space." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0118.

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proteins and genes act in coordinated ways, and their relations are visualized as networks. Networks are more accurate descriptions of cancer regulatory mechanisms, in comparison to lists of oncogenes and tumor suppressors. To extract essential regulators (nodes) and connections (edges), interrogations of these networks are performed, e.g. cancer cells are subjected to different treatments. Interrogations force cancer cells to engage nodes and edges essential for maintaining cancer properties, i.e. drivers, and nonessential followers. The challenge is to discriminate which of the mechanisms drive tumorigenesis, and which are followers. Interrogation of cancer cells under variable g-forces is the treatment to which cancer cells are not normally exposed. Therefore, low (weightlessness) and high (acceleration) g-forces may trigger responses, which may differ in part of followers from responses on the Earth, but still engage carcinogenesis-essential drivers nodes and edges. Methodology: Experimental interrogation of human cancer cells to generate carcinogenesis-related regulatory networks was performed by using proteomics, cell biology, biochemistry, immunohistochemistry and bioinformatics tools. We used also reported datasets deposited in various databases. These networks were analyzed with algorithms to extract drivers of carcinogenesis. Results: Systemic analysis of human breast carcinogenesis has shown mechanisms of engagement of all known cancer hallmarks. Moreover, novel hallmarks have emerged, e.g. involvement of mechanisms of virus-cell interaction and RNA/miR processing. The breast cancer networks are rich, with >6,000 involved proteins and genes. The richness of the networks may explain many clinical observations, e.g. personalized response to treatments. Systemic analysis highlighted novel opportunities for treatment of cancer, by identifying key nodes of known and novel hallmark mechanisms. Systemic properties of the cancer network provides an opportunity to study compensatory mechanisms. These compensatory mechanisms frequently contribute to development of resistance to treatment. These mechanisms will be discussed. Cancer cells are not “wired” to function in weightlessness. The cells would have to adapt. This adaptation will include preserving mechanisms driving carcinogenesis, in addition to the space-only-related adaptation. Key carcinogenesis regulators in the space would be the same as on the Earth, while “passenger”-mechanisms would differ. Systems biology allows integration of a space- and the Earth-data, and would extract key regulators, and, subsequently lead to better diagnostic. Conclusion: Systemic analysis of carcinogenesis studies with different ways of interrogation delivered better diagnostic and novel modalities of treatment.
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Raykin, Julia, Alexander Rachev, Michael Zaucha, and Rudolph L. Gleason. "A Combined Theoretical-Experimental Paradigm for Studying Mechanical Conditioning of Tissue Engineered Arteries." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192746.

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There is a great unmet clinical need to develop small diameter tissue engineered blood vessels (TEBV) with low thrombogenicity and immune response, suitable mechanical properties, and a capacity to remodel to their environment [2, 3]. Development of a clinically useful small diameter TEBV will surely rely on techniques from a wide variety of disciplines, ranging from molecular and cell biology and biochemistry to material science and biomechanics. With regard to the latter, biomechanical stimuli, such as cyclic strain, have been shown to stimulate remodeling of collagen gel-derived TEBVs to greatly improve their mechanical behavior [5]. In native blood vessels, remodeling mechanisms appear to be aimed towards maintaining the local, 3-D mechanical environment (i.e., the local stresses or strains). It is becoming increasingly obvious that tissue engineered constructs also adapt to altered mechanical loading, and specific combinations of multidirectional loads appear to have a synergistic effect on the remodeling. Tissue engineered heart valve constructs exposed to cyclic flexure and shear stress, for example, exhibit a five-fold increase in production of extracellular matrix (ECM) constituents compared to constructs exposed to cyclic flexure or shear stress alone [1]. A critical gap remains, however, in understanding the role of both unidirectional and multidirectional loading on TEBV remodeling. Towards this end, we have developed theoretical and experimental frameworks to study remodeling of collagen and fibrin gel-derived TEBVs.
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Hudecek, Jiri, Carlos Granja, Claude Leroy, and Ivan Stekl. "Physics and Biochemistry: How Much They Can Have in Common." In Nuclear Physics Medthods and Accelerators in Biology and Medicine. AIP, 2007. http://dx.doi.org/10.1063/1.2825771.

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Wan, Ping, Sumei Zheng, and Ting Liao. "Exocyst Regulates Drosophila Border Cell Migration and Wing Development." In 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/bbbs-18.2018.36.

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Huo, Yuxin. "A Phenazine Bio-Electrochemical System Integrates Photosynthesis and Fuel Cell." In ICBBB '22: 2022 12th International Conference on Bioscience, Biochemistry and Bioinformatics. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3510427.3510446.

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Reports on the topic "Biochemistry and Cell Biology"

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Williams, Thomas. Cell Biology Board Game: Cell Survival Drive. University of Dundee, 2023. http://dx.doi.org/10.20933/100001276.

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When dangers strike a cell, they are detected by sensors. Sensors tell messengers about the danger. Messengers tell the organiser. The organiser plans the cell defence, using responders and recyclers. Researchers in the MRC-PPU are figuring out how these different parts interact with each other.
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Nielsen, T. B., and J. L. Kidwell. Cell Biology of Hypoxia, 1996. Fort Belvoir, VA: Defense Technical Information Center, September 1996. http://dx.doi.org/10.21236/ada340589.

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Williams, Thomas. Cell Biology Board Game: Cell Survival (Home Version). University of Dundee, 2022. http://dx.doi.org/10.20933/100001271.

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Williams, Thomas. Cell Biology Board Game: Cell Survival (School Version). University of Dundee, 2022. http://dx.doi.org/10.20933/100001270.

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Cells are the smallest units of life. The environment around cells is always changing. Cells need to adapt to survive. This curriculum linked game and lesson plan introduces the world of cells to pupils 8-13. But can they keep their cells alive? This is a guide to how the cell survival resources can be used in a lesson and can be adapted as the teacher sees fit to do so. This lesson is aimed at 8-13 year olds, and fits into an hour long session. The Cell Survival Game has been adapted for both home use and for use in the classroom, and is accompanied by a series of videos. Learning Outcomes – Cells are the smallest unit of life – There are many different types of cells, and some examples of cell types – Cells experience many dangers, and some examples of dangers – How cells notice and defend themselves against dangers Links to the Curriculum – Health and Wellbeing: I am developing my understanding of the human body – Languages: I can find specific information in a straight forward text (book and instructions) to learn new things, I discover new words and phrases (relating to cells) – Mathematics: I am developing a sense of size and amount (by using the dice), I am exploring number processes (addition and subtraction) and understand they represent quantities (steps to finish line), I am learning about measurements (cell sizes) and am exploring patterns (of cell defences against dangers) – Science: I am learning about biodiversity (different types of microbes), body systems, cells and how they work. – Technology: I am learning about new technologies (used to understand how cells work).
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Williams, Thomas. Cell Biology Board Game: Cell Life Cycle Top Trumps. University of Dundee, January 2023. http://dx.doi.org/10.20933/100001277.

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All living things from whole people to single cells and even viruses have life cycles. Explore the weird and wonderful world of life cycles at the level of the cell in this top trumps inspired game. Print and cut out the cards, then play anywhere you want!
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Grego, Sonia, Edward R. Dougherty, Francis J. Alexander, Scott S. Auerbach, Brian R. Berridge, Michael L. Bittner, Warren Casey, et al. Systems Biology for Organotypic Cell Cultures. Office of Scientific and Technical Information (OSTI), August 2016. http://dx.doi.org/10.2172/1313549.

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Przekwas, Andrzej, Tom Friend, Rodrigo Teixeira, Z. J. Chen, and Patrick Wilkerson. Spatial Modeling Tools for Cell Biology. Fort Belvoir, VA: Defense Technical Information Center, October 2006. http://dx.doi.org/10.21236/ada460852.

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Zatz, Martin. Gordon Research Conference On Pineal Cell Biology. Fort Belvoir, VA: Defense Technical Information Center, July 1992. http://dx.doi.org/10.21236/ada264840.

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Gupta, Shweta. The Revolution of Human Organoids in Cell Biology. Natur Library, October 2020. http://dx.doi.org/10.47496/nl.blog.12.

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Organoids are a new research tool derived from human pluripotent or adult stem cells or somatic cells in vitro to form small, self-organizing 3-dimensional structures that simulate many of the functions of native organs
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Park, M. S. Competency development in antibody production in cancer cell biology. Office of Scientific and Technical Information (OSTI), December 1998. http://dx.doi.org/10.2172/290996.

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