Academic literature on the topic 'Bioavailablity'

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Journal articles on the topic "Bioavailablity"

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Wang, Liuqing, Yoko Yamashita, Shingo Komeda, Akiko Saito, and Hitoshi Ashida. "Absorption, metabolism, distribution and faecal excretion of B-type procyanidin oligomers in mice after a single oral administration of black soybean seed coat extract." Food & Function 9, no. 10 (2018): 5362–70. http://dx.doi.org/10.1039/c8fo00852c.

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Zaripheh, Susan, and John W. Erdman. "Factors That Influence the Bioavailablity of Xanthophylls." Journal of Nutrition 132, no. 3 (March 1, 2002): 531S—534S. http://dx.doi.org/10.1093/jn/132.3.531s.

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Koleman, H. A., R. van Zyl, N. Steyn, B. Boneschans, and H. S. Steyn. "Influence of Montmorillonite on the Dissolution and Bioavailablity of Phenyton." Drug Development and Industrial Pharmacy 16, no. 5 (January 1990): 791–805. http://dx.doi.org/10.3109/03639049009114910.

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Emara, L. H., B. S. El-Menshawi, and M. Y. Estefan. "In Vitro-In Vivo Correlation and Comparative Bioavailablity of Vincamine in Prolonged-Release Preparations." Drug Development and Industrial Pharmacy 26, no. 3 (January 2000): 243–51. http://dx.doi.org/10.1081/ddc-100100352.

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Mahmoud, B. M. "Significant reduction in chloroquine bioavailablity following coadministration with the Sudanese beverages Aradaib, Karkadi and Lemon." Journal of Antimicrobial Chemotherapy 33, no. 5 (1994): 1005–9. http://dx.doi.org/10.1093/jac/33.5.1005.

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Dixon, M., K. Lambing, and JI Seeman. "Mini-Review: On the Transfer of Nicotine from Tobacco to the Smoker. A Brief Review of Ammonia and “pH” Factors." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 19, no. 2 (July 1, 2000): 103–13. http://dx.doi.org/10.2478/cttr-2013-0700.

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AbstractA brief review is presented of the scientific literature on the effects of ammonia compounds, when used as tobacco additives, on the smoke chemistry and bioavailablity of nicotine. The review concludes that ammonia compounds used in the manufacture of certain types of tobacco sheet materials:1) contribute to the flavor properties of cigarette smoke,2) do not increase the amount, rate or efficiency of nicotine transferred from tobacco to mainstream smoke (MS),3) do not increase the percentage of nicotine in MS gas phase using the FTC/ISO (Federal Trade Commission/International Organization for Standardization) method,4) have no influence on the determination of MS nicotine yield as measured by the FTC/ISO method, and5) do not increase the total rate or amount of nicotine absorbed by the smoker.The review also examines the use of pH as it relates to tobacco and to smoke and suggests a terminology which more accurately describes the measurement (pH of aqueous extract of tobacco, pH of aqueous extract of smoke, and pH/electrode in smoke). Lastly, a number of research gaps in these areas are identified.
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Argon, Yair, Sophie E. Bresson, Michal T. Marzec, and Adda Grimberg. "Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production." Cells 9, no. 8 (August 6, 2020): 1844. http://dx.doi.org/10.3390/cells9081844.

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Mammals have two insulin-like growth factors (IGF) that are key mediators of somatic growth, tissue differentiation, and cellular responses to stress. Thus, the mechanisms that regulate the bioavailability of IGFs are important in both normal and aberrant development. IGF-I levels are primarily controlled via the growth hormone-IGF axis, in response to nutritional status, and also reflect metabolic diseases and cancer. One mechanism that controls IGF bioavailablity is the binding of circulating IGF to a number of binding proteins that keep IGF in a stable, but receptor non-binding state. However, even before IGF is released from the cells that produce it, it undergoes an obligatory association with a ubiquitous chaperone protein, GRP94. This binding is required for secretion of a properly folded, mature IGF. This chapter reviews the known aspects of the interaction and highlights the specificity issues yet to be determined. The IGF–GRP94 interaction provides a potential novel mechanism of idiopathic short stature, involving the obligatory chaperone and not just IGF gene expression. It also provides a novel target for cancer treatment, as GRP94 activity can be either inhibited or enhanced.
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Calleja, Patricia, Socorro Espuelas, Christine Vauthier, Gilles Ponchel, and Juan M. Irache. "Controlled Release, Intestinal Transport, and Oral Bioavailablity of Paclitaxel Can be Considerably Increased Using Suitably Tailored Pegylated Poly(Anhydride) Nanoparticles." Journal of Pharmaceutical Sciences 104, no. 9 (September 2015): 2877–86. http://dx.doi.org/10.1002/jps.24354.

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Liao, Qi, Lixu He, Guangyuan Tu, Zhihui Yang, Weichun Yang, Jiaqi Tang, Wei Cao, and Haiying Wang. "Simultaneous immobilization of Pb, Cd and As in soil by hybrid iron-, sulfate- and phosphate-based bio-nanocomposite: Effectiveness, long-term stability and bioavailablity/bioaccessibility evaluation." Chemosphere 266 (March 2021): 128960. http://dx.doi.org/10.1016/j.chemosphere.2020.128960.

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Guja, Habtamu, and Kaleab Baye. "Extrinsic iron from soil contributes to Hb regeneration of anaemic rats: implications for foods contaminated with soil iron." British Journal of Nutrition 119, no. 8 (April 12, 2018): 880–86. http://dx.doi.org/10.1017/s0007114518000338.

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AbstractContamination of foods with extrinsic (soil) Fe is common in developing countries. However, the bioavailability of this extrinsic Fe and the extent to which it contributes to Fe nutrition remains unknown. The present study compared the bioavailability of laboratory- and field-threshed teff (Eragrostisis tef (Zucc) Trotter) to evaluate the bioavailablity of extrinsic soil Fe that resulted from the traditional threshing of the staple grain. Using sequential extraction, Fe was fractionated and its solubility was evaluated. The contribution of the additional extrinsic (soil) Fe to the Hb regeneration of Fe-depleted rats was evaluated using a rat Hb depletion–repletion assay. Weanling male Wistar rats (n24) were fed Fe-deficient diet for 21 d, and were then repleted for 14 d with diets: either laboratory-threshed teff (35 mg Fe/kg;n 8), field-threshed teff (35 mg intrinsic Fe/kg+ 120 mg soil Fe/kg;n 8), or FeSO4(control;n8). Fe content of field-threshed teff (29·4 mg/100 g) was four times greater than that of the laboratory-threshed (6·7 mg/100 g) teff (P<0·05). Soil contamination significantly increased the exchangeable, acid-soluble and reducible fractions obtained after sequential extraction. The relative biological value of the field-threshed teff (88 %) was higher than that of the laboratory-threshed (68 %) teff (P<0·05). Soil Fe can contribute to Hb regeneration in Fe-deficient rats. Considering that contamination of foods with soil is common in Ethiopia and other developing countries, it needs to be accounted for in the design and implementation of fortification programmes to prevent excessive intakes. Human studies are needed to confirm the present findings.
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Dissertations / Theses on the topic "Bioavailablity"

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McKillop, Derek John. "Stability and bioavailablity of food folate." Thesis, University of Ulster, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274093.

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Lorton, Diane Mary. "The development of microbial reporters of polycyclic aromatic hydrocarbon bioavailablity." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414481.

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Kirby, Jason K., and n/a. "Trace metal and metalloid accumulation, distribution, and, speciation in Lake Macquarie, N.S.W., Australia." University of Canberra. Resource, Environmental & Heritage Sciences, 2005. http://erl.canberra.edu.au./public/adt-AUC20051129.124508.

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THESIS ORGANISATION This thesis is organised into nine chapters that include seven international and national publications (six accepted and one submitted for publication). The initial overview chapter outlines the justification and direction for this thesis. With the exception of chapter 8 (accepted for publication on the 1st May 2005); all chapters are exact duplicates of published articles in international and national refereed journals (chapters 2 to 7). The initial chapters (2 and 3) presents research findings using a marine fish species, mullet (Mugil cephalus), to measure trace metal bioavailability in Lake Macquarie, NSW Australia. While subsequent chapters (4 to 8) are presenting research under taken to improve the understanding of arsenic cycling in marine and estuarine environments. The final chapter (chapter 9) is a synopsis of the major findings presented in this thesis. Due to the publication nature of this thesis, an unavoidable degree of replication exists within chapters (publications).
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"Bioavailablity and toxicity of lead shot to small mammals and soil invertebrates from Canadian prairie shooting ranges." Thesis, 2004. http://hdl.handle.net/10388/5554.

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Environmental contamination by lead (Pb) from shot pellets is a common cause of poisoning in waterfowl, raptors, passerines, and other wildlife. In Canada and the United States, Pb shot has been banned for waterfowl hunting, but its continued use on shooting ranges contributes tonnes of Pb shot each year into the environment. This study assessed the uptake and toxicity of Pb shot in soil invertebrates, and native small mammals from three Canadian prairie trap and skeet shooting ranges. Information about recreational shooting in the Canadian prairie provinces was obtained by distributing a questionnaire during the fall of 2000 to all identified gun clubs in Alberta, Saskatchewan and Manitoba. The survey return rate was 22%. Three trap and skeet shooting ranges located in Eastend Saskatchewan, Provost Alberta, and Vegreville Alberta were selected as study sites, based on results of the questionnaire. Field research was conducted at the chosen study sites during the summer of 2001. The sublethal effects of Pb on were evaluated in the laboratory using freshly spiked soil and soil collected from the trap and skeet shooting ranges in the fall of 2002. Earthworm lysosomal neutral red retention time (NRRT) was reduced in soil spiked with Pb acetate in a concentration-dependent manner ( < 0.001), and was negatively correlated with earthworm body burdens ( = -0.80, <0.001). After exposure to soil from the three trap and skeet shooting ranges, earthworm growth and fecundity measurements did not differ significantly between any of the skeet ranges and their reference sites. However, NRRT was significantly reduced in all three ranges compared with their reference sites ( < 0.05). Lysosomal NRRT was negatively correlated with Ca((N0₃)₂-extractable Pb ( = -0.80,p < 0.001) and soil total Pb ( = -0.73, < 0.001), and with earthworm Pb tissue levels ( = -0.67, < 0.002). Lead shot density was high in surface soil at all three sites, however soil total Pb (after removal of Pb pellets) and Ca(N0₃)₂-extractable Pb levels were remarkably low and ultimately determined the results for all biological endpoints measured. Small mammal (ground squirrels and deer mice) tissue Pb concentrations measured at all shooting ranges and reference sites fell within the range reflective of background exposure for both species and all tissue types (blood, liver, kidney, femur) measured. Blood Pb concentrations fell below the threshold associated with inhibition of the enzyme 8-aminolevulinic acid dehydratase (ALAD), and no correlation between blood Pb and ALAD activity was found.
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Ketkar, S. S., Sudhir K. Pagire, N. R. Goud, K. R. Mahadik, A. Nangia, and Anant R. Paradkar. "Tracing the architecture of caffeic acid phenethyl ester cocrystals: studies on crystal structure, solubility, and bioavailability implications." 2016. http://hdl.handle.net/10454/8911.

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Yes
Caffeic acid phenethyl ester (CAPE) is a polyphenolic active compound present in popular apiproduct, ‘propolis’ obtained from beehives. Though it has broad therapeutic capability, the bioavailability of CAPE is limited due to poor solubility. In this study, we report novel cocrystals of CAPE engineered using coformers such as caffeine (CAF), isonicotinamide (INIC), nicotinamide (NIC) with enhanced solubility and bioavailability of CAPE. The cocrystals were prepared by microwave-assisted cocrystallization and characterized using PXRD, DSC and Raman spectroscopy. PXRD and DSC confirm the successful formation and phase purity of CAPE-CAF, CAPE-INIC and CAPE-NIC cocrystals. Raman spectra of CAPE cocrystals complement these results in confirming the formation of novel crystalline phases. CAPE-NIC cocrystal was further subjected to X-ray crystallography to understand its molecular arrangement and hydrogen bonding in the crystal structure. The CAPE-NIC cocrystal structure is found to be stabilized by a rare 1,2-benzenediol-amide heterosynthon. Cocrystallization of CAPE with NIC improved its aqueous solubility and pharmacokinetic profile thereby demonstrating 2.76 folds escalation in bioavailability.
We thank UKIERI: UK-India Education and Research Initiative (TPR26) and EPSRC (EP/J003360/1, EP/L027011/1) for providing financial support during this study.
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Books on the topic "Bioavailablity"

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Vergnaud, Jean-Maurice, and Iosif-Daniel Rosca. Assessing Bioavailablility of Drug Delivery Systems: Mathematical Modeling. Taylor & Francis Group, 2005.

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Vergnaud, Jean-Maurice, and Iosif-Daniel Rosca. Assessing Bioavailablility of Drug Delivery Systems: Mathematical Modeling. CRC, 2005.

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Book chapters on the topic "Bioavailablity"

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Prasain, Jeevan K., and Stephen Barnes. "Novel Diarylheptanoids and Metabolism and Bioavailablity of Curcumin." In Studies in Natural Products Chemistry, 201–14. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-444-63603-4.00005-x.

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Paci, Maurizio, Laura Pizzoferrato, and Giuseppe Rotilio. "Structural Modification and Bioavailablity of Starch Components upon the Extent of the Maillard Reaction: An Enzymic Degradation and Solid State 13 C CP MAS NMR Study." In The Maillard Reaction in Foods and Medicine, 437. Elsevier, 2005. http://dx.doi.org/10.1533/9781845698447.8.437a.

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"Conclusions." In Assessing Bioavailablility of Drug Delivery Systems, 213–15. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.bmatt.

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"Definitions." In Assessing Bioavailablility of Drug Delivery Systems, 1–14. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.ch1.

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"Transdermal Therapeutic Systems." In Assessing Bioavailablility of Drug Delivery Systems, 187–212. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.ch10.

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"Intravenous Administration." In Assessing Bioavailablility of Drug Delivery Systems, 15–31. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.ch2.

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"Oral Dosage Forms with Immediate Release." In Assessing Bioavailablility of Drug Delivery Systems, 33–52. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.ch3.

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"Kinetics of Drug Release from Oral Sustained Dosage Forms." In Assessing Bioavailablility of Drug Delivery Systems, 53–80. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.ch4.

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"Bibliography of In Vitro-In Vivo Correlations." In Assessing Bioavailablility of Drug Delivery Systems, 81–90. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.ch5.

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"Plasma Drug Level with Oral Diffusion-Controlled Dosage Forms." In Assessing Bioavailablility of Drug Delivery Systems, 91–123. CRC Press, 2005. http://dx.doi.org/10.1201/9780849330445.ch6.

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