Journal articles: 'Bioactive'

1

Ouma, Stephen, Richard Kagia, and Faith Kamakia. "Determination of pharmacological activity of bioactives in Allium sativum using computational analysis." F1000Research 12 (February 9, 2023): 151. http://dx.doi.org/10.12688/f1000research.130105.1.

Full text

Abstract:

Introduction: Use of natural products for management of diseases has increased widely due to the belief that natural products are less toxic than conventional medicines. Natural products have been utilised for management of chronic diseases such as diabetes and cancers. Respiratory infections have also been managed using natural products. Allium sativum is one of the natural products that has been utilised in the management of SARS-CoV infections, diabetes and cancer. Methods: This study was aimed at screening bioactive agents in Allium sativum using computational analysis. The targets of the bioactive agents were predicted using SwissTargetPrediction tools. Molecular docking followed, where the docking energies of the bioactive agents to the targets were generated. The bioactive agents were analysed for pharmacokinetics properties using SwissADME as well as toxicity profiles using the ProTox II webserver. The docking scores, toxicities and pharmacokinetics profiles of the bioactive agents in Allium sativum were compared with those of reference compounds. Results: All the bioactives showed lower docking scores than the reference compounds. The bioactives, however, showed some activity on specific receptors such as carbonic anhydrases, cyclooxygenase and ghrelin. All the bioactives showed high gastrointestinal tract absorption and none violated Lipinski’s rule of five. Diallyl trisulphide was predicted to be most lethal, with an LD50 of 100mg/kg, while was the safest, with 8000mg/kg. Conclusions: In conclusion, bioactives showed lower docking scores than the reference compounds, therefore overall pharmacological activity could be attributed to synergy between the bioactives for a particular receptor.

APA, Harvard, Vancouver, ISO, and other styles

2

Postružnik, Vesna, Slađana Stajčić, Dragana Borjan, Gordana Ćetković, Željko Knez, Maša Knez Marevci, and Jelena Vulić. "Impact of Storage Conditions on Stability of Bioactive Compounds and Bioactivity of Beetroot Extract and Encapsulates." Processes 12, no. 7 (June 28, 2024): 1345. http://dx.doi.org/10.3390/pr12071345.

Full text

Abstract:

(1) Background: In this study, bioactive compounds (phenolics and betalains) extracted from beetroot were stabilized by encapsulation with maltodextrin and soy protein by the freeze drying method. Stability of bioactive compounds and bioactivities in a beetroot extract and encapsulates during 60 days of storage at 4 °C (without light) and at 25 °C (with and without light) were investigated. (2) Methods: Contents of bioactive compounds and bioactivity (antioxidant activity by DPPH, RP, and ABTS tests; anti-inflammatory and antihyperglycemic activity) were determined. Improvement in stability of bioactives’ content and bioactivity of prepared encapsulates in relation to the extract was observed after storage at room temperature under light conditions. (3) Results: Encapsulation with maltodextrin showed improvement in stability of all studied bioactive parameters, while an encapsulate with soy protein improved stability of bioactives and antioxidant activity compared to the extract. The encapsulated beetroot extract represents a promising food additive for functional foods due to their content of bioactive compounds and consequent bioactivities.

APA, Harvard, Vancouver, ISO, and other styles

3

Yates, Allison A., Johanna T. Dwyer, John W. Erdman, Janet C. King, Barbara J. Lyle, Barbara O. Schneeman, and Connie M. Weaver. "Perspective: Framework for Developing Recommended Intakes of Bioactive Dietary Substances." Advances in Nutrition 12, no. 4 (May 7, 2021): 1087–99. http://dx.doi.org/10.1093/advances/nmab044.

Full text

Abstract:

ABSTRACT Dietary bioactives are food substances that promote health but are not essential to prevent typical deficiency conditions. Examples include lutein and zeaxanthin, omega-3 fatty acids, and flavonoids. When quality evidence is available, quantified intake recommendations linking dietary bioactives with specific health benefits will enable health professionals to provide evidence-based information to consumers. Without evidence-based recommendations, consumers use information from available sources that often lack standards and rigor. This article describes a framework to develop guidance based on quality evidence fully vetted for efficacy and safety by qualified experts, and designed to communicate the amounts of specific dietary bioactive compounds with identified health benefits. The 4-step Framework described here can be adapted by credible health organizations to work within their guideline development process. Standards of practice used in clinical guidelines are adapted to quantify dietary bioactive intake recommendations from foods consumed by the general public, by taking into account that side effects and trade-offs are often needed for medical treatments but are not acceptable for dietary bioactives. In quantifying dietary bioactive recommendations, this Framework establishes 4 decision-making steps: 1) characterize the bioactive, determine amounts in specific food sources, and quantify intakes; 2) evaluate safety; 3) quantify the causal relation between the specific bioactive and accepted markers of health or normal function via systematic evidence reviews; and 4) translate the evidence into a quantified bioactive intake statement. This Framework provides a working model that can be updated as new approaches are advanced.

APA, Harvard, Vancouver, ISO, and other styles

4

Evans, Levi W., Samantha S. Romanick, and Bradley S. Ferguson. "Natural product inhibitors of acetyl-lysine erasers in the prevention and treatment of heart failure." Functional Foods in Health and Disease 7, no. 8 (August 31, 2017): 577. http://dx.doi.org/10.31989/ffhd.v7i8.376.

Full text

Abstract:

Background: Heart failure (HF) is a major public health concern, with five-year mortality rates following first admission for HF being approximately 50%, thereby stressing the need for novel therapeutic approaches. Histone deacetylases (HDACs) govern lysine acetylation of histone tails that regulates nucleosmal DNA. HDAC inhibitors have emerged as efficacious therapies in pre-clinical models of HF. Interest in diet-gene interactions has given rise to the study of ‘food bioactives’ as epigenetic regulators of gene expression that control human health and disease. These reports demonstrate that bioactive food compounds regulate epigenetic marks that link diet to gene regulation. In fact, others have also shown that bioactive compounds can target HDACs for inhibition; accordingly, bioactive food compounds offer unique opportunities for therapeutic intervention and prevention of heart failure. Lastly, there is emerging interest into how these food bioactives function together or as additives within foods ‘functional foods’ to regulate epigenetic disease. This review will highlight bioactive compound HDAC inhibitors and their role in the heart.Keywords: acetylation, bioactive compounds, dietary HDAC inhibitors, HDACs, histone deacetylases

APA, Harvard, Vancouver, ISO, and other styles

5

Ramadan, Mohamed Fawzy, Alessandra Durazzo, and Massimo Lucarini. "Advances in Research on Food Bioactive Molecules and Health." Molecules 26, no. 24 (December 19, 2021): 7678. http://dx.doi.org/10.3390/molecules26247678.

Full text

Abstract:

Fresh and processed food products are rich in bioactive molecules, including polysaccharides, vitamins, carotenoids, peptides, antioxidants, phenolics, phytosterols, and novel lipids. Bioactive molecules in food could prevent several diseases (i.e., metabolic syndrome, cardiovascular diseases, cancer, etc.). Thus, consumer awareness is growing about the health-promoting impact of food bioactive molecules. Health claims are essential added-value features, wherein health-enhancing potential of bioactives depend on their chemical structure. On the other hand, the investigation of the structure-function relationship of food bioactive molecules is of importance. In this regard, Molecules is delighted to highlight the importance of food bioactive molecules and their effect on health. In this Special Issue of Molecules, researchers are invited to contribute original research and up-to-date reviews.

APA, Harvard, Vancouver, ISO, and other styles

6

Bordoni, A., C. Boesch, C. Malpuech-Brugère, C. Orfila, and L. Tomás-Cobos. "The role of bioactives in energy metabolism and metabolic syndrome." Proceedings of the Nutrition Society 78, no. 3 (April 10, 2019): 340–50. http://dx.doi.org/10.1017/s0029665119000545.

Full text

Abstract:

Some food bioactives potentially exert anti-obesity effects. Anthocyanins (ACN), catechins, β-glucan (BG) and n-3 long chain PUFA (LCPUFA) are among the most promising candidates and have been considered as a strategy for the development of functional foods counteracting body weight gain. At present, clinical trials, reviews and meta-analyses addressing anti-obesity effects of various bioactives or bioactive-rich foods show contradictory results. Abdominal obesity is an important criterion for metabolic syndrome (MetS) diagnosis along with glucose intolerance, dyslipidaemia and hypertension. Food bioactives are supposed to exert beneficial effects on these parameters, therefore representing alternative therapy approaches for the treatment of MetS. This review summarises outcomes on MetS biomarkers in recent clinical trials supplementing ACN, catechins, BG and n-3 LCPUFA, focusing mainly on anti-obesity effects. Overall, it is clear that the level of evidence for the effectiveness varies not only among the different bioactives but also among the different putative health benefits suggested for the same bioactive. Limited evidence may be due to the low number of controlled intervention trials or to inconsistencies in trial design, i.e. duration, dose and/or the method of bioactive supplementation (extracts, supplements, rich or enriched food). At present, the question ‘Are bioactives effective in weight management and prevention of metabolic syndrome?’ remains inconclusive. Thus, a common effort to harmonise the study design of intervention trials focusing on the most promising bioactive molecules is urgently needed to strengthen the evidence of their potential in the treatment of obesity, MetS and related diseases.

APA, Harvard, Vancouver, ISO, and other styles

7

Cecchi, Nicola, Roberta Romanelli, Flavia Ricevuti, Maria Grazia Carbone, Michele Dinardo, Elisabetta Cesarano, Alfredo De Michele, et al. "Bioactives in Oral Nutritional Supplementation: A Pediatric Point of View." Nutrients 16, no. 13 (June 28, 2024): 2067. http://dx.doi.org/10.3390/nu16132067.

Full text

Abstract:

Background: Oral nutritional supplements (ONSs) are crucial for supporting the nutritional needs of pediatric populations, particularly those with medical conditions or dietary deficiencies. Bioactive compounds within ONSs play a pivotal role in enhancing health outcomes by exerting various physiological effects beyond basic nutrition. However, the comprehensive understanding of these bioactives in pediatric ONSs remains elusive. Objective: This systematic narrative review aims to critically evaluate the existing literature concerning bioactive compounds present in oral nutritional supplements from a pediatric standpoint, focusing on their types, sources, bioavailability, physiological effects, and clinical implications. Methods: A systematic search was conducted across the major academic databases, including PubMed, Scopus, and Web of Science, employing predefined search terms related to oral nutritional supplements, bioactives, and pediatrics. Studies published between 2013 and 2024 were considered eligible for inclusion. Data extraction and synthesis were performed according to the PRISMA guidelines. Results: The initial search yielded 558 of articles, of which 72 met the inclusion criteria. The included studies encompassed a diverse range of bioactive compounds present in pediatric ONS formulations, including, but not limited to, vitamins, minerals, amino acids, prebiotics, probiotics, and phytonutrients. These bioactives were sourced from various natural and synthetic origins and were found to exert beneficial effects on growth, development, immune function, gastrointestinal health, cognitive function, and overall well-being in pediatric populations. However, variations in bioavailability, dosing, and clinical efficacy were noted across different compounds and formulations. Conclusions: Bioactive compounds in oral nutritional supplements offer promising avenues for addressing the unique nutritional requirements and health challenges faced by pediatric populations. However, further research is warranted to elucidate the optimal composition, dosage, and clinical applications of these bioactives in pediatric ONS formulations. A deeper understanding of these bioactive compounds and their interplay with pediatric health may pave the way for personalized and effective nutritional interventions in pediatric clinical practice.

APA, Harvard, Vancouver, ISO, and other styles

8

K B S, Sushma. "Bioactive Glass: A Review." International Journal of Science and Research (IJSR) 12, no. 6 (June 5, 2023): 1645–49. http://dx.doi.org/10.21275/sr23612165802.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Günal-Köroğlu, Deniz, Aysenur Betul Bilgin, Gulsah Karabulut, Beyza Saricaoglu, and Esra Capanoglu. "Encapsulation of hydrophobic compounds in yeast cells: methods, characterization, and applications." Exploration of Foods and Foodomics 2, no. 3 (June 20, 2024): 252–74. http://dx.doi.org/10.37349/eff.2024.00037.

Full text

Abstract:

Encapsulation is a pivotal technique for protecting and enhancing the efficiency of sensitive natural bioactive substances, notably essential oils, vitamins, and phenolic compounds, widely used in foods and nutraceuticals. Critical considerations in selecting encapsulation agents encompass safety, release kinetics, stability, and cost-effectiveness. Yeast cells emerge as versatile carriers distinguished by their low cost, compatibility with biological systems, and eco-friendly degradation properties, accommodating both hydrophilic and hydrophobic bioactive agents. Various yeast strains, including Saccharomyces cerevisiae, Torulopsis lipofera, Cutaneotrichosporon curvatus, Yarrowia lipolytica, and Candida utilis, find utility in microencapsulation. Yeast cell encapsulation relies on the permeation of bioactive agents through yeast cell walls, predominantly composed of mannoproteins and polysaccharides. The encapsulation process includes passive or vacuum-infused diffusion of bioactive compounds inside yeast cells, precise droplet size control, and attractive forces to trap bioactive components within cellular structures. Yeast cells display versatility in various states, whether alive or dead, intact or plasmolyzed. In addition, the loading capacity of hydrophobic bioactives can be increased through chemical pretreatment techniques such as plasmolysis, autolysis, and enzyme hydrolysis, freeing up space within yeast cells by eliminating water-soluble components. In summary, yeast cell encapsulation presents a promising and sustainable technology with diverse applications within the food industry. Yeast cells enhance the stability and controlled release of bioactive compounds, magnifying the efficacy of natural hydrophobic bioactives like curcumin, essential oils, β-carotene, and vitamin D across various food products. This comprehensive review focuses on the encapsulation procedures, influential factors, characterization techniques, and applications, with a pronounced emphasis on hydrophobic materials.

APA, Harvard, Vancouver, ISO, and other styles

10

Donsì, Francesco, and Giovanna Ferrari. "Changing the Vision in Smart Food Design Utilizing the Next Generation of Nanometric Delivery Systems for Bioactive Compounds." Foods 9, no. 8 (August 12, 2020): 1100. http://dx.doi.org/10.3390/foods9081100.

Full text

Abstract:

In modern foods, the delivery systems for bioactive compounds play a fundamental role in health promotion, wellbeing, and disease prevention through diet. Nanotechnology has secured a fundamental role in the fabrication of delivery systems with the capability of modulating the in-product and in-body behavior for augmenting bioavailability and activity of bioactive compounds. Structured nanoemulsions and nanoparticles, liposomes, and niosomes can be designed to improve bioactives preservation after ingestion, mucoadhesion, as well as of their release and pathophysiological relevance. In the future, it is expected that the delivery systems will also contribute to augment the efficacy of the bioactive compounds, for example by improving the intestinal absorption and delivery in the bloodstream, as well as promoting the formation of additional bioactive metabolites by regulating the transformations taking place during digestion and the interaction with the intestinal microbiota.

APA, Harvard, Vancouver, ISO, and other styles

11

Ghini, Veronica, Leonardo Tenori, Francesco Capozzi, Claudio Luchinat, Achim Bub, Corinne Malpuech-Brugere, Caroline Orfila, Luigi Ricciardiello, and Alessandra Bordoni. "DHA-Induced Perturbation of Human Serum Metabolome. Role of the Food Matrix and Co-Administration of Oat β-glucan and Anthocyanins." Nutrients 12, no. 1 (December 27, 2019): 86. http://dx.doi.org/10.3390/nu12010086.

Full text

Abstract:

Docosahexaenoic acid (DHA) has been reported to have a positive impact on many diet-related disease risks, including metabolic syndrome. Although many DHA-enriched foods have been marketed, the impact of different food matrices on the effect of DHA is unknown. As well, the possibility to enhance DHA effectiveness through the co-administration of other bioactives has seldom been considered. We evaluated DHA effects on the serum metabolome administered to volunteers at risk of metabolic syndrome as an ingredient of three different foods. Foods were enriched with DHA alone or in combination with oat beta-glucan or anthocyanins and were administered to volunteers for 4 weeks. Serum samples collected at the beginning and end of the trial were analysed by NMR-based metabolomics. Multivariate and univariate statistical analyses were used to characterize modifications in the serum metabolome and to evaluate bioactive-bioactive and bioactive-food matrix interactions. DHA administration induces metabolome perturbation that is influenced by the food matrix and the co-presence of other bioactives. In particular, when co-administered with oat beta-glucan, DHA induces a strong rearrangement in the lipoprotein profile of the subjects. The observed modifications are consistent with clinical results and indicate that metabolomics represents a possible strategy to choose the most appropriate food matrices for bioactive enrichment.

APA, Harvard, Vancouver, ISO, and other styles

12

Sharma, Manoj B., Hend A. M. Abdelmohsen, Özlem Kap, Volkan Kilic, Nesrin Horzum, David Cheneler, and John G. Hardy. "Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release." Bioengineering 11, no. 7 (June 25, 2024): 649. http://dx.doi.org/10.3390/bioengineering11070649.

Full text

Abstract:

Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches in vitro. The pHEMA hydrogel microneedles had mechanical properties that were sufficiently robust to penetrate soft tissues (exemplified here by phantom tissues). The bioactive release from the pHEMA hydrogel-based microneedles was fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application in the transdermal delivery of bioactives (exemplified here by estradiol, melatonin and meropenem) for the treatment of various conditions.

APA, Harvard, Vancouver, ISO, and other styles

13

Kussmann, Martin, and David Henrique Abe Cunha. "Nature has the answers: Discovering and validating natural bioactives for human health." Bioactive Compounds in Health and Disease 5, no. 10 (November 4, 2022): 222. http://dx.doi.org/10.31989/bchd.v5i10.1000.

Full text

Abstract:

Nature has the answer to many of our questions about human health. Natural bioactives, especially when derived from sustainable plant and food sources, provide a plethora of molecular solutions to nutritionally actionable, chronic conditions. The spectrum of these conditions, such as metabolic, immune, and gastrointestinal disorders, has changed with prolonged human life span, which should be matched with an appropriately extended health span: “adding years to life and adding life to years”. Natural bioactives can be classified into micronutrients (i.e., vitamins, and minerals), phytonutrients, bioactive peptides,and pre-, pro-, post- and synbiotics. Bioactives act in concert and interact with the human host and its (gut) microbiome. Therefore, the future of translational science on natural bioactives is being built on a: (a) systems-level rather than reductionist approaches to understanding their interdependent, and at times additive functions, as well as their interactions with the human host and (gut) microbiome; and (b) the leverage of artificial intelligence for discovery and validation, thereby substantially reducing the time from idea and concept to finished solutions for consumers and patients. Rather than focusing on a particular class of bioactive food molecules, as often done in molecular food and nutrition articles, this review embraces a broad range of these bioactives and puts them into perspective regarding a more efficient and sustainable leverage of the biochemical richness of plants and foods for its diverse positive effects on human health.Keywords: bioactive, micronutrient, phytonutrient, prebiotic, probiotic, synbiotic, peptide, artificial intelligence, discovery, validation

APA, Harvard, Vancouver, ISO, and other styles

14

Jin, Juri, Md Helal Uddin Chowdhury, Md Hafizur Rahman, Ki-Young Choi, and Md Adnan. "Bioactive Compounds and Signaling Pathways of Wolfiporia extensa in Suppressing Inflammatory Response by Network Pharmacology." Life 13, no. 4 (March 27, 2023): 893. http://dx.doi.org/10.3390/life13040893.

Full text

Abstract:

Wolfiporia extensa (WE) is a medicinal mushroom and an excellent source of naturally occurring anti-inflammatory substances. However, the particular bioactive compound(s) and mechanism(s) of action against inflammation have yet to be determined. Here, we studied anti-inflammatory bioactive compounds and their molecular mechanisms through network pharmacology. Methanol (ME) extract of WE (MEWE) was used for GC-MS analysis to identify the bioactives, which were screened by following Lipinski’s rules. Public databases were used to extract selected bioactives and inflammation-related targets, and Venn diagrams exposed the common targets. Then, STRING and Cytoscape tools were used to construct protein-protein (PPI) network and mushroom-bioactives-target (M-C-T) networks. Gene Ontology and KEGG pathway analysis were performed by accessing the DAVID database and molecular docking was conducted to validate the findings. The chemical reactivity of key compounds and standard drugs was explored by the computational quantum mechanical modelling method (DFT study). Results from GC-MS revealed 27 bioactives, and all obeyed Lipinski’s rules. The public databases uncovered 284 compound-related targets and 7283 inflammation targets. A Venn diagram pointed to 42 common targets which were manifested in the PPI and M-C-T networks. KEGG analysis pointed to the HIF-1 signaling pathway and, hence, the suggested strategy for preventing the onset of inflammatory response was inhibition of downstream NFKB, MAPK, mTOR, and PI3K-Akt signaling cascades. Molecular docking revealed the strongest binding affinity for “N-(3-chlorophenyl) naphthyl carboxamide” on five target proteins associated with the HIF-1 signaling pathway. Compared to the standard drug utilized in the DFT (Density Functional Theory) analysis, the proposed bioactive showed a good electron donor component and a reduced chemical hardness energy. Our research pinpoints the therapeutic efficiency of MEWE and this work suggests a key bioactive compound and its action mechanism against inflammation.

APA, Harvard, Vancouver, ISO, and other styles

15

Cruz-Martins, Natália, Cristina Quispe, Celale Kırkın, Ezgi Şenol, Aslı Zuluğ, Beraat Özçelik, Adedayo O. Ademiluyi, et al. "Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder." Oxidative Medicine and Cellular Longevity 2021 (August 21, 2021): 1–17. http://dx.doi.org/10.1155/2021/1131280.

Full text

Abstract:

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, luteolin, and resveratrol have revealed excellent neuroprotective effects and can be effectively used in the treatment of neuropsychological disorders. However, the number of clinical trials is limited, and none of them have been approved for the treatment of autism or autism-related disorder. Further clinical studies are needed to effectively assess the real potential of such bioactive molecules.

APA, Harvard, Vancouver, ISO, and other styles

16

K.Shakila, K. Shakila, D. Sukumar D. Sukumar, R. Priya R. Priya, and R. Rajaselvi R.Rajaselvi. "Bioactive Polyphenols Of Bombax Ceiba." International Journal of Scientific Research 1, no. 1 (June 1, 2012): 62–63. http://dx.doi.org/10.15373/22778179/jun2012/22.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Badr, Ahmed Noah, Karolina Gromadzka, Mohamed Gamal Shehata, Kinga Stuper-Szablewska, Kinga Drzewiecka, and Adel Gabr Abdel-Razek. "Prospective antimycotoxigenic action of wild Opuntia ficus-indica by-products." Czech Journal of Food Sciences 38, No. 5 (October 30, 2020): 308–14. http://dx.doi.org/10.17221/11/2020-cjfs.

Full text

Abstract:

Numerous natural compounds perform pharmaceutical, antimycotic and antitoxic purposes in the body system. The aim was to evaluate new phytoconstituents that provide antimycotoxigenic properties against mycotoxins. Bioactive materials chosen were fruit peels and cladodes of wild Opuntia ficus-indica containing a measurable quantity of bioactive phytochemicals. The highest concentration of bioactive metabolites was recorded for protocatechuic and t-cinnamic acids. A reduction effect of bioactives was estimated against aflatoxins, ochratoxin A and zearalenone in a simulated body system. Antifungal activity was determined in liquid media to evaluate antimycotic properties. Lyophilised extracts caused an aflatoxin reduction in media by 14.65% to 23.77% for fruit peels and cladodes, respectively. It caused a decrease of 59% zearalenone and 51% of ochratoxin A in a in a simulated body fluid. The cladode extract manifested better antimycotic and antimycotoxigenic characteristics due to its bioactive contents. These results support a modern antimycotoxin trend of food preservation that has a considerable impact on food safety.

APA, Harvard, Vancouver, ISO, and other styles

18

Agrawal, Manas Yogendra, Shreyas Gaikwad, Sangeeta Srivastava, and Sanjay K. Srivastava. "Research Trend and Detailed Insights into the Molecular Mechanisms of Food Bioactive Compounds against Cancer: A Comprehensive Review with Special Emphasis on Probiotics." Cancers 14, no. 22 (November 8, 2022): 5482. http://dx.doi.org/10.3390/cancers14225482.

Full text

Abstract:

In an attempt to find a potential cure for cancer, scientists have been probing the efficacy of the food we eat and its bioactive components. Over the decades, there has been an exponentially increasing trend of research correlating food and cancer. This review explains the molecular mechanisms by which bioactive food components exhibit anticancer effects in several cancer models. These bioactive compounds are mainly plant based or microbiome based. While plants remain the primary source of these phytochemicals, little is known about probiotics, i.e., microbiome sources, and their relationships with cancer. Thus, the molecular mechanisms underlying the anticancer effect of probiotics are discussed in this review. The principal mode of cell death for most food bioactives is found to be apoptosis. Principal oncogenic signaling axes such as Akt/PI3K, JAK/STAT, and NF-κB seem to be modulated due to these bioactives along with certain novel targets that provide a platform for further oncogenic research. It has been observed that probiotics have an immunomodulatory effect leading to their chemopreventive actions. Various foods exhibit better efficacy as complete extracts than their individual phytochemicals, indicating an orchestrated effect of the food components. Combining bioactive agents with available chemotherapies helps synergize the anticancer action of both to overcome drug resistance. Novel techniques to deliver bioactive agents enhance their therapeutic response. Such combinations and novel approaches are also discussed in this review. Notably, most of the food components that have been studied for cancer have shown their efficacy in vivo. This bolsters the claims of these studies and, thus, provides us with hope of discovering anticancer agents in the food that we eat.

APA, Harvard, Vancouver, ISO, and other styles

19

Daliri, Eric, Deog Oh, and Byong Lee. "Bioactive Peptides." Foods 6, no. 5 (April 26, 2017): 32. http://dx.doi.org/10.3390/foods6050032.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

IWAMORI, Masao. "Bioactive Glycosphingolipids." Journal of Japan Oil Chemists' Society 40, no. 5 (1991): 361–69. http://dx.doi.org/10.5650/jos1956.40.361.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

HENCH, LARRY L. "Bioactive Ceramics." Annals of the New York Academy of Sciences 523, no. 1 Bioceramics (June 1988): 54–71. http://dx.doi.org/10.1111/j.1749-6632.1988.tb38500.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Wiederschain, G. Ya. "Bioactive Peptides." Biochemistry (Moscow) 75, no. 5 (May 2010): 671. http://dx.doi.org/10.1134/s0006297910050214.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Xiao, Jianbo, and Weibin Bai. "Bioactive phytochemicals." Critical Reviews in Food Science and Nutrition 59, no. 6 (March 26, 2019): 827–29. http://dx.doi.org/10.1080/10408398.2019.1601848.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Shahidi, Fereidoon, and Ying Zhong. "Bioactive Peptides." Journal of AOAC INTERNATIONAL 91, no. 4 (July 1, 2008): 914–31. http://dx.doi.org/10.1093/jaoac/91.4.914.

Full text

Abstract:

Abstract Peptides with biological activities, released during gastrointestinal digestion or food processing, play an important role in metabolic regulation and modulation, suggesting their potential use as nutraceuticals and functional food ingredients for health promotion and disease risk reduction. Many studies have reported that peptides from various food sources possess bioactivities, including antihypertensive, antioxidant, anticancer, antimicrobial, and opioid activities as well as immunomodulatory and cholesterol-lowering effects. More studies are being performed exploring the sources, bioavailabilities, and possible physiological/functional properties and the mechanisms of action of bioactive peptides. Technological approaches in terms of peptide preparation, purification, and characterization have also been investigated.

APA, Harvard, Vancouver, ISO, and other styles

25

Shibuya, Terry Y., Sanghun Kim, Kevin Nguyen, Johnny Do, Christine E. McLaren, Kuo-Tung Li, Wen-Pin Chen, et al. "Bioactive Suture." Clinical Cancer Research 10, no. 20 (October 15, 2004): 7088–99. http://dx.doi.org/10.1158/1078-0432.ccr-04-0052.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

HUBBELL, J. "Bioactive biomaterials." Current Opinion in Biotechnology 10, no. 2 (April 1, 1999): 123–29. http://dx.doi.org/10.1016/s0958-1669(99)80021-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Cao, Wanpeng, and Larry L. Hench. "Bioactive materials." Ceramics International 22, no. 6 (January 1996): 493–507. http://dx.doi.org/10.1016/0272-8842(95)00126-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Beldie, Cameluta, Severian Dumitriu, Nicolae Aelenei, Marcel Popa, Marcel I. Popa, and Daniela Dumitriu. "Bioactive polymers." Biomaterials 10, no. 9 (November 1989): 622–24. http://dx.doi.org/10.1016/0142-9612(89)90117-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Neligan, Peter C. "Bioactive Sutures." Plastic and Reconstructive Surgery 118, no. 7 (December 2006): 1645–47. http://dx.doi.org/10.1097/01.prs.0000248418.23513.1f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Hengerer, A., E. Prohaska, J. Decker, S. Hauck, E. Yacoub, S. Kößlinger, U. Reischl, S. Drost, and Herbert Wolf. "Bioactive Films." Materials Science Forum 287-288 (August 1998): 169–80. http://dx.doi.org/10.4028/www.scientific.net/msf.287-288.169.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Ducheyne, P. "Bioactive ceramics." Journal of Bone and Joint Surgery. British volume 76-B, no. 6 (November 1994): 861–62. http://dx.doi.org/10.1302/0301-620x.76b6.7983107.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Bala, Saroj, Diksha Garg, Kandi Sridhar, Baskaran Stephen Inbaraj, Ranjan Singh, Srinivasulu Kamma, Manikant Tripathi, and Minaxi Sharma. "Transformation of Agro-Waste into Value-Added Bioproducts and Bioactive Compounds: Micro/Nano Formulations and Application in the Agri-Food-Pharma Sector." Bioengineering 10, no. 2 (January 23, 2023): 152. http://dx.doi.org/10.3390/bioengineering10020152.

Full text

Abstract:

The agricultural sector generates a significant amount of waste, the majority of which is not productively used and is becoming a danger to both world health and the environment. Because of the promising relevance of agro-residues in the agri-food-pharma sectors, various bioproducts and novel biologically active molecules are produced through valorization techniques. Valorization of agro-wastes involves physical, chemical, and biological, including green, pretreatment methods. Bioactives and bioproducts development from agro-wastes has been widely researched in recent years. Nanocapsules are now used to increase the efficacy of bioactive molecules in food applications. This review addresses various agri-waste valorization methods, value-added bioproducts, the recovery of bioactive compounds, and their uses. Moreover, it also covers the present status of bioactive micro- and nanoencapsulation strategies and their applications.

APA, Harvard, Vancouver, ISO, and other styles

33

Alsharairi, Naser A. "A Review with a Focus on Vaccinium-Berries-Derived Bioactive Compounds for the Treatment of Reproductive Cancers." Plants 13, no. 7 (April 8, 2024): 1047. http://dx.doi.org/10.3390/plants13071047.

Full text

Abstract:

Cancers of the reproductive organs, including prostate, bladder, ovarian, and cervical cancers, are considered the most common causes of death in both sexes worldwide. The genus Vaccinium L. (Ericaceae) comprises fleshy berry crop species, including cranberries, blueberries, lingonberries, bilberries, and bog bilberries, and are widely distributed in many countries. Flavonols, anthocyanins (ACNs), proanthocyanidins (PACs), and phenolic acids are the most bioactive compounds naturally found in Vaccinium berries and have been extensively used as anticancer agents. However, it remains uncertain whether Vaccinium bioactives have a therapeutic role in reproductive cancers (RCs), and how these bioactives could be effective in modulating RC-related signalling pathways/molecular genes. Therefore, this article aims to review existing evidence in the PubMed/MEDLINE database on Vaccinium berries’ major bioactive compounds in RC treatment and unravel the mechanisms underlying this process.

APA, Harvard, Vancouver, ISO, and other styles

34

Jin, Yuanyuan, Ling Chen, Yufen Yu, Muhammad Hussain, and Hao Zhong. "Bioactive Components in Fruit Interact with Gut Microbes." Biology 12, no. 10 (October 13, 2023): 1333. http://dx.doi.org/10.3390/biology12101333.

Full text

Abstract:

Fruits contain many bioactive compounds, including polysaccharides, oligosaccharides, polyphenols, anthocyanins, and flavonoids. All of these bioactives in fruit have potentially beneficial effects on gut microbiota and host health. On the one hand, fruit rich in active ingredients can act as substrates to interact with microorganisms and produce metabolites to regulate the gut microbiota. On the other hand, gut microbes could promote health effects in the host by balancing dysbiosis of gut microbiota. We have extensively analyzed significant information on bioactive components in fruits based on Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Although the deep mechanism of action of bioactive components in fruits on gut microbiota needs further study, these results also provide supportive information on fruits as a source of dietary active ingredients to provide support for the adjunctive role of fruits in disease prevention and treatment.

APA, Harvard, Vancouver, ISO, and other styles

35

El-Ramady, Hassan, Peter Hajdú, Gréta Törős, Khandsuren Badgar, Xhensila Llanaj, Attila Kiss, Neama Abdalla, et al. "Plant Nutrition for Human Health: A Pictorial Review on Plant Bioactive Compounds for Sustainable Agriculture." Sustainability 14, no. 14 (July 7, 2022): 8329. http://dx.doi.org/10.3390/su14148329.

Full text

Abstract:

Is there any relationship between plant nutrition and human health? The overall response to this question is very positive, and a strong relationship between the nutrition of plants and humans has been reported in the literature. The nutritional status of edible plants consumed by humans can have a negative or positive impact on human health. This review was designed to assess the importance of plant bioactive compounds for human health under the umbrella of sustainable agriculture. With respect to the first research question, it was found that plant bioactives (e.g., alkaloids, carotenoids, flavonoids, phenolics, and terpenoids) have a crucial role in human health due to their therapeutic benefits, and their potentiality depends on several factors, including botanical, environmental, and clinical attributes. Plant bioactives could be produced using plant tissue culture tools (as a kind of agro-biotechnological method), especially in cases of underexploited or endangered plants. Bioactive production of plants depends on many factors, especially climate change (heat stress, drought, UV radiation, ozone, and elevated CO2), environmental pollution, and problematic soils (degraded, saline/alkaline, waterlogged, etc.). Under the previously mentioned stresses, in reviewing the literature, a positive or negative association was found depending on the kinds of stress or bioactives and their attributes. The observed correlation between plant bioactives and stress (or growth factors) might explain the importance of these bioactives for human health. Their accumulation in stressed plants can increase their tolerance to stress and their therapeutic roles. The results of this study are in keeping with previous observational studies, which confirmed that the human nutrition might start from edible plants and their bioactive contents, which are consumed by humans. This review is the first report that analyzes this previously observed relationship using pictorial presentation.

APA, Harvard, Vancouver, ISO, and other styles

36

Sadiq, Uzma, Harsharn Gill, and Jayani Chandrapala. "Casein Micelles as an Emerging Delivery System for Bioactive Food Components." Foods 10, no. 8 (August 23, 2021): 1965. http://dx.doi.org/10.3390/foods10081965.

Full text

Abstract:

Bioactive food components have potential health benefits but are highly susceptible for degradation under adverse conditions such as light, pH, temperature and oxygen. Furthermore, they are known to have poor solubilities, low stabilities and low bioavailabilities in the gastrointestinal tract. Hence, technologies that can retain, protect and enable their targeted delivery are significant to the food industry. Amongst these, microencapsulation of bioactives has emerged as a promising technology. The present review evaluates the potential use of casein micelles (CMs) as a bioactive delivery system. The review discusses in depth how physicochemical and techno-functional properties of CMs can be modified by secondary processing parameters in making them a choice for the delivery of food bioactives in functional foods. CMs are an assembly of four types of caseins, (αs1, αs2, β and κ casein) with calcium phosphate. They possess hydrophobic and hydrophilic properties that make them ideal for encapsulation of food bioactives. In addition, CMs have a self-assembling nature to incorporate bioactives, remarkable surface activity to stabilise emulsions and the ability to bind hydrophobic components when heated. Moreover, CMs can act as natural hydrogels to encapsulate minerals, bind with polymers to form nano capsules and possess pH swelling behaviour for targeted and controlled release of bioactives in the GI tract. Although numerous novel advancements of employing CMs as an effective delivery have been reported in recent years, more comprehensive studies are required to increase the understanding of how variation in structural properties of CMs be utilised to deliver bioactives with different physical, chemical and structural properties.

APA, Harvard, Vancouver, ISO, and other styles

37

Makeieva, Liudmyla, Iryna Gladyr, Rita Rozhnova, and Nataliia Galatenko. "Synthesis of Bioactive Folate-Ferrocene Conjugate." Chemistry & Chemical Technology 8, no. 4 (December 5, 2014): 395–400. http://dx.doi.org/10.23939/chcht08.04.395.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Otvos, Reka A., Kristina B. M. Still, Govert W. Somsen, August B. Smit, and Jeroen Kool. "Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays." SLAS DISCOVERY: Advancing the Science of Drug Discovery 24, no. 3 (January 25, 2019): 362–85. http://dx.doi.org/10.1177/2472555218822098.

Full text

Abstract:

Natural extracts are complex mixtures that may be rich in useful bioactive compounds and therefore are attractive sources for new leads in drug discovery. This review describes drug discovery from natural products and in explaining this process puts the focus on ion-channel drug discovery. In particular, the identification of bioactives from natural products targeting nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors (5-HT3Rs) is discussed. The review is divided into three parts: “Targets,” “Sources,” and “Approaches.” The “Targets” part will discuss the importance of ion-channel drug targets in general, and the α7-nAChR and 5-HT3Rs in particular. The “Sources” part will discuss the relevance for drug discovery of finding bioactive compounds from various natural sources such as venoms and plant extracts. The “Approaches” part will give an overview of classical and new analytical approaches that are used for the identification of new bioactive compounds with the focus on targeting ion channels. In addition, a selected overview is given of traditional venom-based drug discovery approaches and of diverse hyphenated analytical systems used for screening complex bioactive mixtures including venoms.

APA, Harvard, Vancouver, ISO, and other styles

39

Jacquier, Emma F., Marcel van de Wouw, Elena Nekrasov, Nikhat Contractor, Amira Kassis, and Diana Marcu. "Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?" Foods 13, no. 5 (February 28, 2024): 739. http://dx.doi.org/10.3390/foods13050739.

Full text

Abstract:

Scientific advancements in understanding the impact of bioactive components in foods on the gut microbiota and wider physiology create opportunities for designing targeted functional foods. The selection of bioactive ingredients with potential local or systemic effects holds promise for influencing overall well-being. An abundance of studies demonstrate that gut microbiota show compositional changes that correlate age and disease. However, navigating this field, especially for non-experts, remains challenging, given the abundance of bioactive ingredients with varying levels of scientific substantiation. This narrative review addresses the current knowledge on the potential impact of the gut microbiota on host health, emphasizing gut microbiota resilience. It explores evidence related to the extensive gut health benefits of popular dietary components and bioactive ingredients, such as phytochemicals, fermented greens, fibres, prebiotics, probiotics, and postbiotics. Importantly, this review distinguishes between the potential local and systemic effects of both popular and emerging ingredients. Additionally, it highlights how dietary hormesis promotes gut microbiota resilience, fostering better adaptation to stress—a hallmark of health. By integrating examples of bioactives, this review provides insights to guide the design of evidence-based functional foods aimed at priming the gut for resilience.

APA, Harvard, Vancouver, ISO, and other styles

40

Bellantone, M., and Larry L. Hench. "Bioactive Behaviour of Sol-Gel Derived Antibacterial Bioactive Glass." Key Engineering Materials 192-195 (September 2000): 617–20. http://dx.doi.org/10.4028/www.scientific.net/kem.192-195.617.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Sarmiento-Tovar, Aixa A., Laura Silva, Jeysson Sánchez-Suárez, and Luis Diaz. "Streptomyces-Derived Bioactive Pigments: Ecofriendly Source of Bioactive Compounds." Coatings 12, no. 12 (November 30, 2022): 1858. http://dx.doi.org/10.3390/coatings12121858.

Full text

Abstract:

Pigments have been used since historical times and are currently used in food, cosmetic, pharmaceutical, and other industries. One of the main sources of natural pigments are plants and insects; however, microorganisms are of great interest due to their bioactivities and advantages in their production. Actinobacteria, especially the genus Streptomyces, are biotechnologically valuable, producing specialized metabolites with a broad spectrum of bioactivities, such as antioxidant, anticancer, antibiofilm, antifouling, and antibiotic activities, as well as pigments, among others. In this review, we identify, summarize, and evaluate the evidence regarding the potential of Streptomyces strains to be biological sources of bioactive pigments. To conclude, future research will include purifying pigmented extracts that have already been reported, studying the purified compounds in a specific application, isolating new microorganisms from new isolation sources, improving the production of pigments already identified, modifying culture media or using new technologies, and developing new extraction techniques and a wide range of solvents that are ecofriendly and efficient.

APA, Harvard, Vancouver, ISO, and other styles

42

Par, Matej, Zrinka Tarle, Reinhard Hickel, and Nicoleta Ilie. "Polymerization kinetics of experimental bioactive composites containing bioactive glass." Journal of Dentistry 76 (September 2018): 83–88. http://dx.doi.org/10.1016/j.jdent.2018.06.012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Doria, Enrico, Daniela Buonocore, Antonio Marra, Valeria Bontà, Andrea Gazzola, Maurizia Dossena, Manuela Verri, and Cinzia Calvio. "Bacterial-Assisted Extraction of Bioactive Compounds from Cauliflower." Plants 11, no. 6 (March 18, 2022): 816. http://dx.doi.org/10.3390/plants11060816.

Full text

Abstract:

The market for nutraceutical molecules is growing at an impressive pace in all Western countries. A convenient source of bioactive compounds is found in vegetable waste products, and their re-use for the recovery of healthy biomolecules would increase the sustainability of the food production system. However, safe, cheap, and sustainable technologies should be applied for the recovery of these beneficial molecules, avoiding the use of toxic organic solvents or expensive equipment. The soil bacterium Bacillus subtilis is naturally endowed with several enzymes targeting complex vegetable polymers. In this work, a raw bacterial culture supernatant was used to assist in the extraction of bioactives using isothermal pressurization cycles. Besides a wild-type Bacillus subtilis strain, a new strain showing increased secretion of cellulases and xylanases, pivotal enzymes for the digestion of the plant cell wall, was also used. Results indicate that the recovery of compounds correlates with the amount of cellulolytic enzymes applied, demonstrating that the pretreatment with non-purified culture broth effectively promotes the release of bioactives from the vegetable matrix. Therefore, this approach is a valid and sustainable procedure for the recovery of bioactive compounds from food waste.

APA, Harvard, Vancouver, ISO, and other styles

44

Tsoupras, Alexandros, Donal Moran, Thomas Byrne, James Ryan, Luke Barrett, Con Traas, and Ioannis Zabetakis. "Anti-Inflammatory and Anti-Platelet Properties of Lipid Bioactives from Apple Cider By-Products." Molecules 26, no. 10 (May 12, 2021): 2869. http://dx.doi.org/10.3390/molecules26102869.

Full text

Abstract:

The valorization of food industry by-products as sources of bioactive compounds is at the forefront of research in functional foods and nutraceuticals. This study focuses on bioactives of apple cider by-products (ACBPs) with putative cardio-protective properties. Total lipids (TLs) were extracted from ACBPs of apple varieties that are low (ACBP1), medium (ACBP2), and high (ACBP3) in tannins and were further separated into polar lipids (PLs) and neutral lipids (NLs). The functionality of these lipid extracts and of their HPLC-derived lipid fractions/PL subclasses were assessed in vitro against human platelet aggregation induced by the thrombotic and inflammatory platelet agonists platelet-activating factor (PAF) and adenosine diphosphate (ADP). The fatty acid profile of PLs and their most bioactive lipid fractions were evaluated by GC–MS analysis. The PL extracts exhibited higher specificity against the PAF-induced platelet aggregation compared to their anti-ADP effects, while TL and NL showed lower bioactivities in all ACBPs. HPLC analysis unveiled that the most bioactive PL from all ACBPs were those in PL fraction 3 containing phosphatidylcholines (PCs). PLs from all ACBPs and their PC bioactives were rich in polyunsaturated fatty acids (PUFAs) and especially in the essential omega-6 (n-6) linoleic acid (LA) and omega-3 (n-3) alpha linolenic acid (ALA), with favorably low values of the n-6/n-3 PUFA ratio, thus providing a rationale for their higher anti-inflammatory bioactivities. Within this study, highly bioactive PL compounds with strong anti-inflammatory and anti-platelet properties were identified in ACBPs, which can be potentially utilized for producing cardio-protective functional foods and/or nutraceuticals.

APA, Harvard, Vancouver, ISO, and other styles

45

Cornelia, Melanie, Kam Natania, Herry Cahyana, and Edison Sutiyono. "Encapsulation of Soursop (Annona muricata Linn.) Leaf Tea Extract Using Natural Mucilage." Reaktor 19, no. 1 (May 10, 2019): 26–33. http://dx.doi.org/10.14710/reaktor.19.1.26-33.

Full text

Abstract:

The bioactively rich soursop leaf extract can be encapsulated inside several natural coating materials. The extract of soursop leaf has been found to contain many bioactive compounds such as various phenolic compounds that are beneficial for anticancer, antidiabetic and many other health benefits. However due to the sensitive nature of the bioactive molecules, encapsulation procedure was applied to prolong the activity of the biomolecules. Capsule materials used in this experiment were obtained from natural extract of Okra mucilage, Aloe vera mucilage and Maltodextrin-WPI mixture to protect the unstable bioactive compounds. Homogenation time using ultrasonication and Core to Coating ratio was differed to observe the optimum encapsulation process. The encapsulation efficiency, release factor ability, size distribution and its correlation with bioactive stability are observed using Total Phenolic methods and Antioxidant Activity before and after encapsulation. Aloe vera gave best encapsulation efficiency (88-91%) while microcapsule made with Okra gave the best antioxidant activity (DPPH IC50 633-710ppm), and maltodextrin-WPI gave best powder recovery (yield 70-73%). Keywords: aloe mucilage, antioxidant activity, encapsulation, okra mucilage, soursop tea extract

APA, Harvard, Vancouver, ISO, and other styles

46

Vulić, Jelena, Ksenija Bibovski, Vanja Šeregelj, Strahinja Kovačević, Milica Karadžić Banjac, Jasna Čanadanović-Brunet, Gordana Ćetković, Dragana Četojević-Simin, Vesna Tumbas Šaponjac, and Sanja Podunavac-Kuzmanović. "Chemical and Biological Properties of Peach Pomace Encapsulates: Chemometric Modeling." Processes 10, no. 4 (March 25, 2022): 642. http://dx.doi.org/10.3390/pr10040642.

Full text

Abstract:

Background: Bioactive compounds need to resist food processing, be released from the food matrix, and be bioaccessible in the gastrointestinal tract in order to provide health benefits. Bioactive compounds isolated from peach pomace (PP) were encapsulated using four different wall materials to improve their stability and to evaluate the effects of in vitro gastrointestinal digestion, as well as chemometric modeling among obtained encapsulates. Methods: Phenolics and carotenoids content, antioxidant, antihyperglycemic, anti-inflammatory, and cell growth activities were evaluated after gastric and intestinal digestion steps. Chemometrics classification analysis–principal component analysis and hierarchical cluster analysis revealed grouping among encapsulates. Results: The encapsulation of PP bioactive compounds showed a protective effect against pH changes and enzymatic activities along digestion, and thereby contributed to an increase in their bioaccessibility in gastric and intestinal fluids. Conclusions: The obtained results suggest protein and polysaccharide carriers and the freeze-drying technique, as an efficient method for the encapsulation of bioactives from PP, could find use in the food and pharmaceutical industry.

APA, Harvard, Vancouver, ISO, and other styles

47

Hager, Roland, Johannes Pitsch, Jakob Kerbl-Knapp, Cathrina Neuhauser, Nicole Ollinger, Marcus Iken, Josef Ranner, et al. "A High-Content Screen for the Identification of Plant Extracts with Insulin Secretion-Modulating Activity." Pharmaceuticals 14, no. 8 (August 17, 2021): 809. http://dx.doi.org/10.3390/ph14080809.

Full text

Abstract:

Bioactive plant compounds and extracts are of special interest for the development of pharmaceuticals. Here, we describe the screening of more than 1100 aqueous plant extracts and synthetic reference compounds for their ability to stimulate or inhibit insulin secretion. To quantify insulin secretion in living MIN6 β cells, an insulin–Gaussia luciferase (Ins-GLuc) biosensor was used. Positive hits included extracts from Quillaja saponaria, Anagallis arvensis, Sapindus mukorossi, Gleditsia sinensis and Albizia julibrissin, which were identified as insulin secretion stimulators, whereas extracts of Acacia catechu, Myrtus communis, Actaea spicata L., Vaccinium vitis-idaea and Calendula officinalis were found to exhibit insulin secretion inhibitory properties. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) were used to characterize several bioactive compounds in the selected plant extracts, and these bioactives were retested for their insulin-modulating properties. Overall, we identified several plant extracts and some of their bioactive compounds that may be used to manipulate pancreatic insulin secretion.

APA, Harvard, Vancouver, ISO, and other styles

48

Nahum, Victoria, and Abraham J. Domb. "Recent Developments in Solid Lipid Microparticles for Food Ingredients Delivery." Foods 10, no. 2 (February 11, 2021): 400. http://dx.doi.org/10.3390/foods10020400.

Full text

Abstract:

Health food has become a prominent force in the market place, influencing many food industries to focus on numerous bioactive compounds to reap benefits from its properties. Use of these compounds in food matrices has several limitations. Most of the food bio-additives are sensitive compounds that may quickly decompose in both food and within the gastrointestinal tract. Since most of these bioactives are highly or partially lipophilic molecules, they possess very low water solubility and insufficient dispersibility, leading to poor bioavailability. Thus, various methods of microencapsulation of large number of food bioactives have been studied. For encapsulation of hydrophobic compounds several lipid carriers and lipid platforms have been studied, including emulsions, microemulsions, micelles, liposomes, and lipid nano- and microparticles. Solid lipid particles (SLP) are a promising delivery system, can both deliver bioactive compounds, reduce their degradation, and permit slow and sustained release. Solid lipid particles have important advantages compared to other polymer carriers in light of their simple production technology, including scale up ability, higher loading capacity, extremely high biocompatibility, and usually low cost. This delivery system provides improved stability, solubility in various matrixes, bioavailability, and targeting properties. This article reviews recent studies on microencapsulation of selected bioactive food ingredients in solid lipid-based carriers from a point of view of production methods, characteristics of obtained particles, loading capability, stability, and release profile.

APA, Harvard, Vancouver, ISO, and other styles

49

Salar, Francisco J., Vicente Agulló, Raúl Domínguez-Perles, and Cristina García-Viguera. "Influence of Sweeteners (Sucrose, Sucralose, and Stevia) on Bioactive Compounds in a Model System Study for Citrus–Maqui Beverages." Foods 11, no. 15 (July 29, 2022): 2266. http://dx.doi.org/10.3390/foods11152266.

Full text

Abstract:

Recently, new formulations of beverages with low sugar and high bioactive compound contents are being demanded because of their association with metabolic health. However, the sweeteners’ influences on the bioactive compounds remain underexplored. In this sense, this work aims to evaluate the interactions between different bioactive compounds such as flavonoids, vitamin C, and sweeteners (sucrose, stevia, and sucralose) in a functional citrus–maqui beverage. For this purpose, the phytochemical behavior was studied, in model system solutions, during one-month storage at 4 °C. The results obtained corroborated previous descriptions of the interactions between these compounds. However, when studying the bioactives in the model solutions, the loss of flavanones in the citrus solution increased up to 29%, while anthocyanin losses decreased to 27%. The vitamin C losses ranged from 100% (beverage) to 46% (ascorbic acid solution). Regardless, an influence of the sweeteners was observed. Sucrose reduced the anthocyanin and flavanone losses in both model solutions and the beverage, while sucralose increased flavanone loss. Finally, all sweeteners increased vitamin C degradation (up to 75%) when compared to the model solution. In conclusion, sweeteners added to beverages should be taken into account, depending on the bioactive compounds that should be preserved during storage.

APA, Harvard, Vancouver, ISO, and other styles

50

Ruiz Flores, Gabriel, Maricela Quiroz-Bravo, Mario Márquz Lemus, Diana Maylet Hernández-Martínez, and Ma del Socorro López-Cortez. "Effect of Processing Stage on the Bioactives of Tomato Purees Supplemented Preserved by Microwaves." Journal of the Mexican Chemical Society 67, no. 2 (April 1, 2023): 103–21. http://dx.doi.org/10.29356/jmcs.v67i2.1877.

Full text

Abstract:

Abstract. Tomatoes are a natural source of bioactive compounds. Most of these substances accumulate in the tomato skin and seeds and are scarce in the pulp, which is the main ingredient of tomato products. The application of technological processes as well as plant variety, cultivation, and harvesting conditions, can significantly affect the content and composition of phenolics in tomato fruit and tomato-based products. To increase the content of bioactive, in the present investigation a tomato puree supplemented with the seeds and skin of the fruit was prepared using tomatoes of Mexican origin. The bioactive compounds at each stage of the process were evaluated. The variation in bioactive compounds occurred during the tomato juice concentration stage. The retention of bioactive compounds was similar when conventional pasteurization and microwave treatment were applied independently, however, the microwave used a lower time. Tomato puree supplemented with seeds and skin presented a higher content of bioactive. There were no significant differences in the microbiological activity between pasteurization and microwave treatment since both heat treatments achieved similar microbial inactivation. Chlorogenic acid, rutin, resveratrol, quercetin, and naringenin were identified by HPLC. The microwave-treated tomato puree presented a less acidic taste, a more intense red color, and a more pleasant aroma compared to the pasteurized tomato puree. The PCA analysis showed that the processing stages that affect the polyphenolic content in the elaboration of tomato purees corresponded to the heat treatments appliednd and the concentration stage. Resumen. Los tomates son una fuente natural de bioactivos. La mayoría de estas sustancias se acumulan en la piel y las semillas del tomate y son escasas en la pulpa, que es el ingrediente principal de los productos derivados del tomate. La aplicación de procesos tecnológicos, así como la variedad de plantas, el cultivo y las condiciones de cosecha, pueden afectar significativamente el contenido y la composición de compuestos fenólicos en el fruto del tomate y los productos a base de tomate. Para aumentar el contenido de bioactivos, en la presente investigación se preparó un puré de tomate suplementado con las semillas y la piel del fruto utilizando tomates de origen mexicano. Se evaluaron los compuestos bioactivos en cada etapa del proceso. La variación de los compuestos bioactivos ocurrió durante la etapa de concentración del jugo de tomate. La retención de compuestos bioactivos fue similar cuando la pasteurización convencional y el tratamiento con microondas se aplicaron de forma independiente, sin embargo, el microondas usó un tiempo menor. El puré de tomate suplementado con semillas y piel presentó mayor contenido de bioactivos. No hubo diferencias significativas en la actividad microbiológica entre la pasteurización y el tratamiento con microondas ya que ambos tratamientos térmicos lograron una inactivación microbiana similar. Por HPLC se identificaron ácido clorogénico, rutina, resveratrol, quercetina y naringenina. El puré de tomate tratado con microondas presentó un sabor menos ácido, un color rojo más intenso y un aroma más agradable en comparación con el puré de tomate pasteurizado. El análisis PCA mostró que las etapas de procesamiento que inciden en el contenido polifenólico en la elaboración de purés de tomate correspondieron a los tratamientos térmicos aplicados y la etapa de concentración.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Bioactive'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles