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Journal articles on the topic 'Bioactive Synthesis'

Author: Grafiati

Published: 6 September 2023

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1

Makeieva, Liudmyla, Iryna Gladyr, Rita Rozhnova, and Nataliia Galatenko. "Synthesis of Bioactive Folate-Ferrocene Conjugate." Chemistry & Chemical Technology 8, no. 4 (December 5, 2014): 395–400. http://dx.doi.org/10.23939/chcht08.04.395.

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2

Hou, Si-Hua, Feng-Fan Zhou, Yi-Hang Sun, and Quan-Zhe Li. "Deconstructive and Divergent Synthesis of Bioactive Natural Products." Molecules 28, no. 17 (August 22, 2023): 6193. http://dx.doi.org/10.3390/molecules28176193.

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Natural products play a key role in innovative drug discovery. To explore the potential application of natural products and their analogues in pharmacology, total synthesis is a key tool that provides natural product candidates and synthetic analogues for drug development and potential clinical trials. Deconstructive synthesis, namely building new, challenging structures through bond cleavage of easily accessible moieties, has emerged as a useful design principle in synthesizing bioactive natural products. Divergent synthesis, namely synthesizing many natural products from a common intermediate, can improve the efficiency of chemical synthesis and generate libraries of molecules with unprecedented structural diversity. In this review, we will firstly introduce five recent and excellent examples of deconstructive and divergent syntheses of natural products (2021–2023). Then, we will summarize our previous work on the deconstructive and divergent synthesis of natural products to demonstrate the high efficiency and simplicity of these two strategies in the field of total synthesis.

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3

Ito, Y., J. J. Gaudino, and J. C. Paulson. "Synthesis of bioactive sialosides." Pure and Applied Chemistry 65, no. 4 (January 1, 1993): 753–62. http://dx.doi.org/10.1351/pac199365040753.

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4

Ansary, Inul, and Nasrin Jahan. "Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy." SynOpen 07, no. 02 (May 2023): 209–42. http://dx.doi.org/10.1055/s-0042-1751453.

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AbstractThis review reports the synthesis of various bioactive macrocycles, involving ring-closing metathesis as a key step, developed since ca. 2000. These macrocycles exhibited biological activities such as antiviral, antifungal, antibacterial, and anticancer activities, and more. Thus, their syntheses and utilization are essential for both synthetic organic and medicinal chemists.

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5

Hussein, Essam M., and Khalid S. Khairou. "Sonochemistry: Synthesis of bioactive heterocycles." Review Journal of Chemistry 4, no. 3 (July 2014): 221–51. http://dx.doi.org/10.1134/s2079978014030030.

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6

Hussein, Essam M., and Khalid S. Khairou. "Sonochemistry: Synthesis of Bioactive Heterocycles." Synthetic Communications 44, no. 15 (June 13, 2014): 2155–91. http://dx.doi.org/10.1080/00397911.2014.893360.

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7

Sharma, Praveen Kumar, and M. Kumar. "Synthesis of bioactive substituted pyrazolylbenzothiazinones." Research on Chemical Intermediates 41, no. 9 (June 13, 2014): 6141–48. http://dx.doi.org/10.1007/s11164-014-1727-1.

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8

Yuvaraj, S., Monica Mendon, Asha Almeida, Mini Dhiman, and Manju Girish. "Synthesis of novel bioactive pyrazolothiazoles." Medicinal Chemistry Research 23, no. 5 (October 31, 2013): 2667–75. http://dx.doi.org/10.1007/s00044-013-0825-8.

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9

Banerjee, Bubun. "Green Synthesis of Bioactive Heterocycles." Current Green Chemistry 9, no. 3 (March 2023): 124–25. http://dx.doi.org/10.2174/221334610903230102122357.

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10

Sharma, Upendra, Inder Kumar, and Rakesh Kumar. "Recent Advances in the Regioselective Synthesis of Indoles via C–H Activation/Functionalization." Synthesis 50, no. 14 (May 28, 2018): 2655–77. http://dx.doi.org/10.1055/s-0037-1609733.

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Indole is an important heterocyclic motif that occurs ubiquitously in bioactive natural products and pharmaceuticals. Immense efforts have been devoted to the synthesis of indoles starting from the Fisher indole synthesis to the recently developed C–H activation/functionalization-based methods. Herein, we have reviewed the progress made on the regioselective synthesis of functionalized indoles, including 2-substituted, 3-substituted and 2,3-disusbstituted indoles, since the year 2010.1 Introduction2 Metal-Catalyzed Synthesis of 2-Substituted Indoles3 Metal-Catalyzed Synthesis of 3-Substituted Indoles4 Metal-Free Synthesis of 3-Substituted Indoles5 Metal-Catalyzed 2,3-Disubstituted Indole Synthesis5.1 Metal-Catalyzed Intramolecular 2,3-Disubstituted Indole Synthesis5.2 Metal-Catalyzed Intermolecular 2,3-Disubstituted Indole Synthesis6 Metal-Free 2,3-Disubstituted Indole Synthesis6.1 N-Protected 2,3-Disubstituted Indole Synthesis6.2 N-Unprotected 2,3-Disubstituted Indole Synthesis7 Applications8 Summary and Outlook

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11

Polshettiwar, Vivek, and Rajender S. Varma. "Greener and expeditious synthesis of bioactive heterocycles using microwave irradiation." Pure and Applied Chemistry 80, no. 4 (January 1, 2008): 777–90. http://dx.doi.org/10.1351/pac200880040777.

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The utilization of green chemistry techniques is dramatically reducing chemical waste and reaction times as has recently been proven in several organic syntheses and chemical transformations. To illustrate these advantages in the synthesis of bioactive heterocycles, we have studied various environmentally benign protocols that involve greener alternatives. Microwave (MW) irradiation of neat reactants catalyzed by the surfaces of recyclable mineral supports, such as alumina, silica, clay, or their "doped" versions, enables the rapid one-pot assembly of heterocyclic compounds, such as flavonoids, related benzopyrans, and quinolone derivatives. The strategy to assemble oxygen and nitrogen heterocycles from in situ generated reactive intermediates via enamines or using hypervalent iodine reagents is described. Examples of multicomponent reactions that can be adapted for rapid parallel synthesis include solventless synthesis of dihydropyrimidine-2(1H)-ones (Biginelli reaction), imidazo[1,2-a]annulated pyridines, pyrazines, and pyrimidines (Ugi reaction). The relative advantages of greener pathways, which use MW irradiation and eco-friendly aqueous reaction medium, for the synthesis of various heterocycles, such as N-aryl azacycloalkanes, isoindoles, 1,3-dioxane, 1,3,4-oxadiazole, 1,3,4-thiadiazole, pyrazole, and diazepines, are also summarized.

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12

Ishida, Hideharu, and Makoto Kiso. "Chemical Synthesis of Bioactive Oligosaccharides. Systematic Syntheses of Gangliosides." Trends in Glycoscience and Glycotechnology 13, no. 69 (2001): 57–64. http://dx.doi.org/10.4052/tigg.13.57.

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13

Bassora, Bruno K., Carlos E. Da Costa, Rogério A. Gariani, João V. Comasseto, and Alcindo A. Dos Santos. "Tellurium in organic synthesis: synthesis of bioactive butenolides." Tetrahedron Letters 48, no. 8 (February 2007): 1485–87. http://dx.doi.org/10.1016/j.tetlet.2006.12.063.

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14

Mane, Baliram B., D. D. Kumbhar, and Suresh B. Waghmode. "Enantioselective Total Synthesis of Ligraminol D and Ligraminol E." Synlett 30, no. 20 (October 30, 2019): 2285–89. http://dx.doi.org/10.1055/s-0039-1690249.

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As a part of our ongoing research on the synthesis of bioactive constituents or molecules by using an organocatalytic approach, enantioselective total syntheses of ligraminol D and ligraminol E were achieved starting from a commercially available nonchiral aldehyde. Key steps in this synthesis were an asymmetric α-aminoxylation of an aldehyde and a Mitsunobu reaction.

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15

Silva, G. A., F. J. Costa, O. P. Coutinho, S. Radin, P. Ducheyne, and R. L. Reis. "Synthesis and evaluation of novel bioactive composite starch/bioactive glass microparticles." Journal of Biomedical Materials Research 70A, no. 3 (2004): 442–49. http://dx.doi.org/10.1002/jbm.a.30099.

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16

Miyashita, Masaaki. "Recent progress in the synthesis of bioactive polycyclic natural products." Pure and Applied Chemistry 79, no. 4 (January 1, 2007): 651–65. http://dx.doi.org/10.1351/pac200779040651.

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The zoanthamine alkaloids, a type of heptacyclic marine alkaloid isolated from colonial zoanthids of the genus Zoanthus sp., have distinctive biological and pharmacological properties as well as their unique chemical structures with stereochemical complexity. Namely, norzoanthamine can suppress the loss of bone weight and strength in ovariectomized mice and has been considered a promising candidate for an antiosteoporotic drug, whereas zoanthamine has exhibited potent inhibitory activity toward phorbol myristate-induced inflammation in addition to powerful analgesic effects. Recently, norzoanthamine derivatives were demonstrated to inhibit strongly the growth of P-388 murine leukemia cell lines, in addition to their potent antiplatelet activities on human platelet aggregation. These distinctive biological properties, combined with novel chemical structures, make this family of alkaloids extremely attractive targets for chemical synthesis. However, the chemical synthesis of the zoanthamine alkaloids has been impeded owing to their densely fuctionalized complex stereostructures. We report here the first and highly stereoselective total syntheses of norzoanthamine and zoanthamine, which involves stereoselective synthesis of the requisite triene for intramolecular Diels-Alder reaction via three-component coupling reactions, a key intramolecular Diels-Alder reaction, and subsequent crucial bis-aminoacetalization as the key steps.

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17

Susanto, Edy, Anik Fadlilah, and Muhammad Fathul Amin. "Synthesis, extraction and idetification of meat bioactive peptides: a review." IOP Conference Series: Earth and Environmental Science 888, no. 1 (November 1, 2021): 012058. http://dx.doi.org/10.1088/1755-1315/888/1/012058.

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Abstract The consumption of meat should consider the concept of functional food. The meat had a highquality protein and contain of bioactive peptide compounds. Amino acid was component of bioactive peptides compound. It joined by covalent bonds known as amide or peptide bonds. A lot of research was currently focused on the bioactive peptide compounds isolated from myofibril and sarcoplasmic proteins with the synthesis, extraction, and identification methods. This study used a systematic review to get the structure of amino acids that the source of bioactive components and the principle of synthesis, extraction and identification of bioactive peptide in the meat. This paper highlights were finding on the structure of amino acid in the meat. The proportion of amino acids was also different in each animal body location. The result identified that more than 170 peptides were released from the main structure of the myofibril (actin, myosin) and sarcoplasmic muscle proteins, and the synthesis, extraction and bioactive peptide identification in the meat as well as their potential use as functional food.

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18

Pizzuti, Lucas, Alethea Barschak, Francieli Stefanello, Marilia Farias, Claiton Lencina, Mariana Roesch-Ely, Wilson Cunico, Sidnei Moura, and Claudio Pereira. "Environment-friendly Synthesis of Bioactive Pyrazoles." Current Organic Chemistry 18, no. 1 (January 31, 2014): 115–26. http://dx.doi.org/10.2174/13852728113179990029.

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19

Urabe, Daisuke, and Masayuki Inoue. "Convergent Total Synthesis of Bioactive Cardenolides." Journal of Synthetic Organic Chemistry, Japan 77, no. 5 (May 1, 2019): 452–62. http://dx.doi.org/10.5059/yukigoseikyokaishi.77.452.

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20

Bandeira, L. C., P. S. Calefi, K. J. Ciuffi, E. J. Nassar, I. M. M. Salvado, and M. H. F. V. Fernandes. "Low temperature synthesis of bioactive materials." Cerâmica 57, no. 342 (June 2011): 166–72. http://dx.doi.org/10.1590/s0366-69132011000200006.

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Bioactive materials possess properties that allow them to interact with natural tissues to induce reactions that favor the development and regeneration of those tissues. In this study, silica was prepared by the sol-gel method, using tetraethylorthosilicate as the precursor. The calcium and phosphor sources used here were calcium ethoxy and phosphoric acid, respectively, in ethanol solvent. The solid obtained was dried at 50 ºC. In vitro bioactivity assays were performed by soaking the materials in simulated body fluid (SBF). The samples were characterized by transmission electron microscopy (TEM), thermal analysis and photoluminescence. TEM images of the samples before contact with SBF revealed amorphous aggregates and after 12 days in SBF showed two phases, one amorphous with large quantities of Si and O, and the other a crystalline phase whose composition contained Ca and P. The electron diffraction pattern showed a planar distance of 2.86 Å, corresponding to 2θ = 32.2º. This was ascribed to hydroxyapatite. The Eu III was used as structural probe. The relative band intensity correspondent the transition 5D0 → 7F2 / 5D0 → 7F1 showed a high symmetry surrounding the Eu III ion. These materials, produced by the sol-gel route, open up new possibilities for obtaining bioactive biomaterials for medical applications.

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21

Zhibarev, A. M., E. A. Akhmetshin, and E. V. Zharikov. "Synthesis of hydroxyapatite for bioactive coatings." Russian Journal of Inorganic Chemistry 58, no. 12 (December 2013): 1408–11. http://dx.doi.org/10.1134/s0036023613120243.

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22

Coladol, Isidro G., Miguel S. Alonso, Rosario Hernández-Galán, Jose G. Madero, and Guillermo M. Massanet. "Synthesis of bioactive 7-β-hydroxyeudesmanolides." Tetrahedron 50, no. 35 (January 1994): 10531–38. http://dx.doi.org/10.1016/s0040-4020(01)89593-4.

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23

Lepovitz, Lance T., and Stephen F. Martin. "Diversity-Oriented Synthesis of Bioactive Azaspirocycles." Tetrahedron 75, no. 47 (November 2019): 130637. http://dx.doi.org/10.1016/j.tet.2019.130637.

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24

Norcross, Roger D., and Ian Paterson. "Total Synthesis of Bioactive Marine Macrolides." Chemical Reviews 95, no. 6 (September 1995): 2041–114. http://dx.doi.org/10.1021/cr00038a012.

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25

Nasim, H. M. O., S. Ghafoor, A. T. Shah, and A. S. Khan. "Synthesis of phosphate based bioactive glasses." Dental Materials 33 (2017): e59. http://dx.doi.org/10.1016/j.dental.2017.08.116.

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26

Miyaoka, Hiroaki, and Yasuji Yamada. "Total Synthesis of Bioactive Marine Terpenoids." Bulletin of the Chemical Society of Japan 75, no. 2 (February 2002): 203–22. http://dx.doi.org/10.1246/bcsj.75.203.

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27

Weijers, Carel A. G. M., Maurice C. R. Franssen, and Gerben M. Visser. "Glycosyltransferase-catalyzed synthesis of bioactive oligosaccharides." Biotechnology Advances 26, no. 5 (September 2008): 436–56. http://dx.doi.org/10.1016/j.biotechadv.2008.05.001.

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28

Trabocchi, Andrea. "Design and synthesis of bioactive compounds." Bioorganic & Medicinal Chemistry 25, no. 19 (October 2017): 5031. http://dx.doi.org/10.1016/j.bmc.2017.09.020.

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29

ITO, Y., J. J. GAUDINO, and J. C. PAULSON. "ChemInform Abstract: Synthesis of Bioactive Sialosides." ChemInform 24, no. 26 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199326305.

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30

Menéndez, J., Marco Leonardi, Verónica Estévez, and Mercedes Villacampa. "The Hantzsch Pyrrole Synthesis: Non-conventional Variations and Applications of a Neglected Classical Reaction." Synthesis 51, no. 04 (December 3, 2018): 816–28. http://dx.doi.org/10.1055/s-0037-1610320.

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Pyrrole is one of the most important one-ring heterocycles because of its widespread presence in natural products and unnatural bioactive compounds and drugs in clinical use. The preparation of pyrroles by reaction between primary amines, β-dicarbonyl compounds, and α-halo ketones, known as the Hantzsch pyrrole synthesis, is reviewed here for the first time. In spite of its age and its named reaction status, this method has received little attention in the literature. Recent work involving the use of non-conventional conditions has rejuvenated this classical reaction and this is emphasized in this review. Some applications of the Hantzsch reaction in target-oriented synthesis are also discussed.1 Introduction2 The Conventional Hantzsch Pyrrole Synthesis3 Hantzsch Pyrrole Synthesis under Non-conventional Conditions4 Applications of the Hantzsch Pyrrole Synthesis5 Conclusions

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31

Pellissier, Hélène. "Asymmetric Organocatalytic Tandem/Domino Reactions to Access Bioactive Products." Current Organic Chemistry 25, no. 13 (September 2, 2021): 1457–71. http://dx.doi.org/10.2174/1385272825666210208142427.

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Tandem and domino reactions constitute economic methodologies to prepare complex molecules starting from simple materials. Especially, combining these powerful procedures to asymmetric catalysis allows direct access to many elaborated chiral products, including important key intermediates in total syntheses of important biologically active compounds. A range of various types of chiral organocatalysts have already been successfully applied to such syntheses. This review presents major developments in the total synthesis of bioactive products based on the use of enantioselective organocatalytic domino/tandem reactions as key steps. It is divided into three parts, dealing successively with syntheses based on organocatalytic asymmetric Michael-initiated domino reactions as key steps; aldol-initiated domino/tandem reactions and other domino reactions.

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32

Lei, Bo, Xiaofeng Chen, Yingjun Wang, Naru Zhao, Chang Du, and Liming Fang. "Synthesis and bioactive properties of macroporous nanoscale SiO2–CaO–P2O5 bioactive glass." Journal of Non-Crystalline Solids 355, no. 52-54 (December 2009): 2678–81. http://dx.doi.org/10.1016/j.jnoncrysol.2009.09.029.

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33

Salinas, Antonio J., and Maria Vallet-Regí. "The Sol–Gel Production of Bioceramics." Key Engineering Materials 391 (October 2008): 141–58. http://dx.doi.org/10.4028/www.scientific.net/kem.391.141.

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Sol–gel synthesis is used for the fabrication of new materials with technological applications including ceramics for implants manufacturing, usually termed bioceramics. Many bioactive and resorbable bioceramics, that is, calcium phosphates, glasses and glass–ceramics, have been improved by using the sol–gel synthesis. In addition, the soft thermal conditions of sol–gel methods made possible to synthesize more reactive materials than those synthesized by traditional methods. Moreover, new families of bioactive materials such as organic–inorganic hybrids and inorganic compounds with ordered mesostructure can be produced. In hybrid materials, the inorganic component ensures the bioactive response whereas the organic polymeric component allows modulating other properties of the resulting biomaterial such as mechanical properties, degradation, etc. On the other hand, the sol–gel processes also allow the synthesis of silica ordered mesoporous materials, which are bioactive and exhibit – as an added value – a possible application as matrices for the controlled release of biologically active molecules (drugs, peptides, hormones, etc.). Finally, by combining the bioactive glasses composition with synthesis strategies of mesoporous materials, template glasses with ordered mesoporosity can be obtained. In this chapter, the advances that sol–gel technology has brought to the silica-based bioactive bioceramics are presented.

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34

Benkoulouche, Mounir, Régis Fauré, Magali Remaud-Siméon, Claire Moulis, and Isabelle André. "Harnessing glycoenzyme engineering for synthesis of bioactive oligosaccharides." Interface Focus 9, no. 2 (February 15, 2019): 20180069. http://dx.doi.org/10.1098/rsfs.2018.0069.

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Combined with chemical synthesis, the use of glycoenzyme biocatalysts has shown great synthetic potential over recent decades owing to their remarkable versatility in terms of substrates and regio- and stereoselectivity that allow structurally controlled synthesis of carbohydrates and glycoconjugates. Nonetheless, the lack of appropriate enzymatic tools with requisite properties in the natural diversity has hampered extensive exploration of enzyme-based synthetic routes to access relevant bioactive oligosaccharides, such as cell-surface glycans or prebiotics. With the remarkable progress in enzyme engineering, it has become possible to improve catalytic efficiency and physico-chemical properties of enzymes but also considerably extend the repertoire of accessible catalytic reactions and tailor novel substrate specificities. In this review, we intend to give a brief overview of the advantageous use of engineered glycoenzymes, sometimes in combination with chemical steps, for the synthesis of natural bioactive oligosaccharides or their precursors. The focus will be on examples resulting from the three main classes of glycoenzymes specialized in carbohydrate synthesis: glycosyltransferases, glycoside hydrolases and glycoside phosphorylases.

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35

Banerjee, Bubun, and Gurpreet Kaur. "Microwave Assisted Catalyst-free Synthesis of Bioactive Heterocycles." Current Microwave Chemistry 7, no. 1 (June 23, 2020): 5–22. http://dx.doi.org/10.2174/2213335607666200226102010.

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This review deals with the recent advances on the microwave-assisted synthesis of bioactive heterocycles without using any catalyst under various reaction conditions. Synthesis of various biologically promising N-heterocycles, O-heterocycles, S-heterocycles, N as well as O- or S-heterocycles reported so far under catalyst-free microwave-irradiated conditions are discussed in this review.

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36

Guo, Jing-jing, Bi-juan Yang, Chen-xu Jing, Duo-zhi Chen, and Xiao-jiang Hao. "Rapid Synthesis of Ismine, a Bioactive Amaryllidaceae Alkaloid." Journal of Chemical Research 41, no. 4 (April 2017): 202–4. http://dx.doi.org/10.3184/174751917x14894997017496.

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Ismine (6-[2-(methylamino)phenyl]-1,3-benzodioxole-5-methanol, 1), a biologically active alkaloid, has been synthesised by a rapid and simple four-step sequence. This synthesis involved a consecutive aryl–aryl and N–aryl coupling, leading to a phenanthridine derivative in a one-pot sequence, which employed a palladium catalyst and trifurylphosphine as the ligand. This synthesis gave an overall yield of 23%.

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37

Liu, Jiawei, Guo Du, Hongda Yu, Xueyin Zhang, and Tiehong Chen. "Synthesis of Hierarchically Porous Bioactive Glass and Its Mineralization Activity." Molecules 28, no. 5 (February 27, 2023): 2224. http://dx.doi.org/10.3390/molecules28052224.

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Mesoporous bioactive glass is a promising biomaterial for bone tissue engineering due to its good biocompatibility and bioactivity. In this work, we synthesized a hierarchically porous bioactive glass (HPBG) using polyelectrolyte-surfactant mesomorphous complex as template. Through the interaction with silicate oligomers, calcium and phosphorus sources were successfully introduced into the synthesis of hierarchically porous silica, and HPBG with ordered mesoporous and nanoporous structures was obtained. The morphology, pore structure and particle size of HPBG can be controlled by adding block copolymer as co-template or adjusting the synthesis parameters. The ability to induce hydroxyapatite deposition in simulated body fluids (SBF) demonstrated the good in vitro bioactivity of HPBG. Overall, this work provides a general method for the synthesis of hierarchically porous bioactive glasses.

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38

Karageorgis, George, and Herbert Waldmann. "Guided by Evolution: Biology-Oriented Synthesis of Bioactive Compound Classes." Synthesis 51, no. 01 (October 11, 2018): 55–66. http://dx.doi.org/10.1055/s-0037-1610368.

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Biology-oriented-synthesis (BIOS), is a chemocentric approach to identifying structurally novel molecules as tools for chemical biology and medicinal chemistry research. The vast chemical space cannot be exhaustively covered by synthetic chemistry. Thus, methods which reveal biologically relevant portions of chemical space are of high value. Guided by structural conservation in the evolution of both proteins and natural products, BIOS classifies bioactive compound classes in a hierarchical manner based on molecular architecture and bioactivity. Biologically relevant scaffolds inspire and guide the synthesis of BIOS libraries, which calls for the development of suitable synthetic methodologies. These compound collections have enriched biological relevance, leading to the discovery of bioactive small molecules. These potent and selective modulators allow the study of complex biological pathways and may serve as starting points for drug discovery programs. Thus, BIOS can also be regarded as a hypothesis-generating tool, guiding the design and preparation of novel, bioactive molecular scaffolds. This review elaborates the principles of BIOS and highlights selected examples of their application, which have in turn created future opportunities for the expansion of BIOS and its combination with fragment-based compound discovery for the identification of biologically relevant small molecules with unprecedented molecular scaffolds.1 Introduction2 Structural Classification of Natural Products3 Implications and Opportunities for Biology-Oriented Synthesis4 Applications of Biology-Oriented Synthesis4.1 Chemical Structure and Bioactivity Guided Approaches4.2 Natural-Product-Derived Fragment-Based Approaches5 Conclusions and Outlook

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39

Tatsuta, Kuniaki. "Significance of Total Synthesis of Bioactive Compounds." Current Organic Chemistry 5, no. 2 (February 1, 2001): 207–31. http://dx.doi.org/10.2174/1385272013375670.

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40

ISOBE, Minoru. "Stereocontrolled Synthesis of Multi-Functional Bioactive Compounds." Journal of Synthetic Organic Chemistry, Japan 55, no. 1 (1997): 44–55. http://dx.doi.org/10.5059/yukigoseikyokaishi.55.44.

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41

Sepulveda, Pilar, Julian R. Jones, and Larry L. Hench. "Synthesis of Sol-Gel Derived Bioactive Foams." Key Engineering Materials 218-220 (November 2001): 287–90. http://dx.doi.org/10.4028/www.scientific.net/kem.218-220.287.

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42

Kabra, Vijaya, Arpana Meel, Sunita Mitharwal, and Swaroop Singh. "Bioactive Heterocyclic Trithiophosphoric Esters: Synthesis and Bioactivity." Phosphorus, Sulfur, and Silicon and the Related Elements 182, no. 12 (October 18, 2007): 2833–42. http://dx.doi.org/10.1080/10426500701521761.

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43

Khokhani, Kamlesh, Taslimahemad Khatri, and Praful Patel. "One Pot Synthesis of Bioactive Novel Cyanopyridones." Journal of the Korean Chemical Society 57, no. 4 (August 20, 2013): 476–82. http://dx.doi.org/10.5012/jkcs.2013.57.4.476.

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44

Ghani, Ambreen, Erum A. Hussain, Abida Yasmeen, Narjis Naz, and Shaheen Asghar. "Synthesis of Novel 2,4-Disubstituted Bioactive Thiazoles." Asian Journal of Chemistry 26, Supp. (2014): S211—S213. http://dx.doi.org/10.14233/ajchem.2014.19049.

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45

Echalier, Cécile, Coline Pinese, Xavier Garric, Hélène Van Den Berghe, Estelle Jumas Bilak, Jean Martinez, Ahmad Mehdi, and Gilles Subra. "Easy Synthesis of Tunable Hybrid Bioactive Hydrogels." Chemistry of Materials 28, no. 5 (February 16, 2016): 1261–65. http://dx.doi.org/10.1021/acs.chemmater.5b04881.

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46

Goddard, Mary-Lorène, and Raffaele Tabacchi. "Total synthesis of bioactive frustulosin and frustulosinol." Tetrahedron Letters 47, no. 6 (February 2006): 909–11. http://dx.doi.org/10.1016/j.tetlet.2005.11.150.

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Resnati, Giuseppe. "Synthesis of chiral and bioactive fluoroorganic compounds." Tetrahedron 49, no. 42 (1993): 9385–445. http://dx.doi.org/10.1016/s0040-4020(01)80212-x.

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Bachar, Ahmed, Cyrille Mercier, Arnaud Tricoteaux, Anne Leriche, Claudine Follet, and Stuart Hampshire. "Bioactive oxynitride glasses: Synthesis, structure and properties." Journal of the European Ceramic Society 36, no. 12 (September 2016): 2869–81. http://dx.doi.org/10.1016/j.jeurceramsoc.2015.12.017.

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Tamm, Ch. "Biosynthesis and synthesis of bioactive natural lactams." Pure and Applied Chemistry 65, no. 6 (January 1, 1993): 1309–18. http://dx.doi.org/10.1351/pac199365061309.

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Garcı́a-Junceda, Eduardo, Juan Francisco Garcı́a-Garcı́a, Agatha Bastida, and Alfonso Fernández-Mayoralas. "Enzymes in the synthesis of bioactive compounds." Bioorganic & Medicinal Chemistry 12, no. 8 (April 2004): 1817–34. http://dx.doi.org/10.1016/j.bmc.2004.01.032.

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