Relevant bibliographies by topics / Bioactive Synthesis

Academic literature on the topic 'Bioactive Synthesis'

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Published: 6 September 2023

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Journal articles on the topic "Bioactive Synthesis"

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Makeieva, Liudmyla, Iryna Gladyr, Rita Rozhnova, and Nataliia Galatenko. "Synthesis of Bioactive Folate-Ferrocene Conjugate." Chemistry & Chemical Technology 8, no. 4 (December 5, 2014): 395–400. http://dx.doi.org/10.23939/chcht08.04.395.

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Hou, Si-Hua, Feng-Fan Zhou, Yi-Hang Sun, and Quan-Zhe Li. "Deconstructive and Divergent Synthesis of Bioactive Natural Products." Molecules 28, no. 17 (August 22, 2023): 6193. http://dx.doi.org/10.3390/molecules28176193.

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Natural products play a key role in innovative drug discovery. To explore the potential application of natural products and their analogues in pharmacology, total synthesis is a key tool that provides natural product candidates and synthetic analogues for drug development and potential clinical trials. Deconstructive synthesis, namely building new, challenging structures through bond cleavage of easily accessible moieties, has emerged as a useful design principle in synthesizing bioactive natural products. Divergent synthesis, namely synthesizing many natural products from a common intermediate, can improve the efficiency of chemical synthesis and generate libraries of molecules with unprecedented structural diversity. In this review, we will firstly introduce five recent and excellent examples of deconstructive and divergent syntheses of natural products (2021–2023). Then, we will summarize our previous work on the deconstructive and divergent synthesis of natural products to demonstrate the high efficiency and simplicity of these two strategies in the field of total synthesis.
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Ito, Y., J. J. Gaudino, and J. C. Paulson. "Synthesis of bioactive sialosides." Pure and Applied Chemistry 65, no. 4 (January 1, 1993): 753–62. http://dx.doi.org/10.1351/pac199365040753.

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Ansary, Inul, and Nasrin Jahan. "Synthesis of Bioactive Macrocycles Involving Ring-Closing Metathesis Strategy." SynOpen 07, no. 02 (May 2023): 209–42. http://dx.doi.org/10.1055/s-0042-1751453.

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AbstractThis review reports the synthesis of various bioactive macrocycles, involving ring-closing metathesis as a key step, developed since ca. 2000. These macrocycles exhibited biological activities such as antiviral, antifungal, antibacterial, and anticancer activities, and more. Thus, their syntheses and utilization are essential for both synthetic organic and medicinal chemists.
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Hussein, Essam M., and Khalid S. Khairou. "Sonochemistry: Synthesis of bioactive heterocycles." Review Journal of Chemistry 4, no. 3 (July 2014): 221–51. http://dx.doi.org/10.1134/s2079978014030030.

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Hussein, Essam M., and Khalid S. Khairou. "Sonochemistry: Synthesis of Bioactive Heterocycles." Synthetic Communications 44, no. 15 (June 13, 2014): 2155–91. http://dx.doi.org/10.1080/00397911.2014.893360.

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Sharma, Praveen Kumar, and M. Kumar. "Synthesis of bioactive substituted pyrazolylbenzothiazinones." Research on Chemical Intermediates 41, no. 9 (June 13, 2014): 6141–48. http://dx.doi.org/10.1007/s11164-014-1727-1.

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Yuvaraj, S., Monica Mendon, Asha Almeida, Mini Dhiman, and Manju Girish. "Synthesis of novel bioactive pyrazolothiazoles." Medicinal Chemistry Research 23, no. 5 (October 31, 2013): 2667–75. http://dx.doi.org/10.1007/s00044-013-0825-8.

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Banerjee, Bubun. "Green Synthesis of Bioactive Heterocycles." Current Green Chemistry 9, no. 3 (March 2023): 124–25. http://dx.doi.org/10.2174/221334610903230102122357.

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Sharma, Upendra, Inder Kumar, and Rakesh Kumar. "Recent Advances in the Regioselective Synthesis of Indoles via C–H Activation/Functionalization." Synthesis 50, no. 14 (May 28, 2018): 2655–77. http://dx.doi.org/10.1055/s-0037-1609733.

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Indole is an important heterocyclic motif that occurs ubiquitously in bioactive natural products and pharmaceuticals. Immense efforts have been devoted to the synthesis of indoles starting from the Fisher indole synthesis to the recently developed C–H activation/functionalization-based methods. Herein, we have reviewed the progress made on the regioselective synthesis of functionalized indoles, including 2-substituted, 3-substituted and 2,3-disusbstituted indoles, since the year 2010.1 Introduction2 Metal-Catalyzed Synthesis of 2-Substituted Indoles3 Metal-Catalyzed Synthesis of 3-Substituted Indoles4 Metal-Free Synthesis of 3-Substituted Indoles5 Metal-Catalyzed 2,3-Disubstituted Indole Synthesis5.1 Metal-Catalyzed Intramolecular 2,3-Disubstituted Indole Synthesis5.2 Metal-Catalyzed Intermolecular 2,3-Disubstituted Indole Synthesis6 Metal-Free 2,3-Disubstituted Indole Synthesis6.1 N-Protected 2,3-Disubstituted Indole Synthesis6.2 N-Unprotected 2,3-Disubstituted Indole Synthesis7 Applications8 Summary and Outlook
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Dissertations / Theses on the topic "Bioactive Synthesis"

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Zheng, Zehua. "Synthesis of bioactive natural products." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59815.

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Crude extracts of the rare macrofungus Serpula sp. collected from a wooded area in Sri Lanka showed antimicrobial activity. The novel fungal metabolite serpulanine (2.1) was isolated from the crude extract in very small amounts along with a number of additional secondary metabolites. In order to obtain sufficient quantities of serpulanine (2.1) for biological evaluation, a synthetic route was developed to the natural product and a small library of analogs that have been evaluated in a panel of bioassays. Serpulanine (2.1) inhibits the histone deacetylase I/II with a clear dose response curve. Halitoxins (3.1) that are frequently isolated from marine sponges have a complex macrocyclic chemical structure made of different numbers of monomeric alkylpyridinium units. An unknown halitoxin-related natural product named alotau potently inhibited the dephosphorylation activity of calcineurin. With the goal to elucidate the structure of alotau, compounds of one, two and three pyridinium rings (3.10, 3.7 and 3.8) were synthesized. Though these compounds have NMR spectra similar to the natural alotau, according to bioassay results, none of them recapitulates the activity of the unknown natural product alotau. (+)-Makassaric acid 4.1 was isolated in the Andersen Lab from the marine sponge Acanthodendrilla sp. It showed promising activity in a zebrafish screen for new drugs to treat stroke patients. The convergent synthetic scheme shown below was undertaken to conduct structure activity relationship (SAR) studies. The key intermediate 4.17 has been obtained, and further synthetic efforts will be needed to produce 4.1.
Science, Faculty of
Chemistry, Department of
Graduate
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Nelson, A. "Synthesis of bioactive indolizidine alkaloids." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421009.

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Shan, Yulong. "Bioactive carbohydrates : isolation, synthesis and conjugation." Thesis, Bangor University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.556079.

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In this thesis four projects related to bioactive carbohydrates are described. The first project is about the extraction of iminosugars from Hyacinthoides non-scripta. This is the first time that extraction from English bluebell seeds has been described. Efficient extraction and isolation methods are reported. Another project discusses the development of a total synthetic carbohydrate conjugate vaccine candidate against Streptococcus pneumoniae type 14 using Gold nanoparticles as carrier. The synthetic pathway of the introduction of a linker for conjugation, and the deprotection of the tetrasaccharide corresponding to the repeating unit of the Streptococcus pneumoniae type 14 capsular polysaccharide is described. The biological results of the developed vaccine candidate are briefly discussed. In the third project, attempts to synthesise regioselectively sulfated disaccharides to be used in binding studies with FedF adhesin of E. coli are described. In this section, an improved high-yielding method based on the Heyns rearrangement for the synthesis of N-acetyl lactosamine (LacNAc) is also reported. In the fourth part, conjugation of the Lewis b hexasaccharide to be used for studies of Lewis b blood group antigen binding adhesin is reported.
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Carbain, Benoît. "A convenient synthesis of bioactive cyclohexenephosphonates." Thesis, University of Sussex, 2010. http://sro.sussex.ac.uk/id/eprint/2367/.

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Influenza virus infection and the shikimic acid pathway are two of many examples of microbe-host interactions and microbial biosynthetic pathways that are interesting for investigation by means of small molecules. A particularly interesting structural motif common to both is the cyclohexenecarboxylic acid. In the former, this structural motif has been employed as a mimetic of the sialyl cation intermediate and forms the scaffold of the anti-influenza drug and neuraminidase inhibitor Oseltamivir (or TamifluTM). In the latter pathway, crucial modifications towards aromatic amino acids are carried out via shikimic acid, a cyclohexenecarboxylic acid, as a substrate. A straightforward method to replace the carboxylate moiety in such structures with a phosphonate would provide access to a wide variety of mimetics, for instance monoesters, that still retain a negative charge under physiological conditions usually required for bioactivity. The aim of this research project was to develop an efficient synthesis of the cyclohexenephosphonate scaffold from chiral pool precursors via two key steps, a Hunsdiecker-Barton iododecarboxylation followed by a palladiummediated coupling step to introduce the phosphonate moiety, thus giving a convenient access to interesting bioactive molecules. This approach has successfully been applied to the shikimic acid to afford ‘phospha'-shikimic acids and 3-dehydro-‘phospha'-shikimic acids, and further development of this strategy has led to the synthesis of ‘phospha'-Tamiflu and its derivatives from an Oseltamivir precursor.
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Usai, Igor. "Synthesis of novel bioactive doxycycline derivatives." kostenfrei, 2008. http://www.opus.ub.uni-erlangen.de/opus/volltexte/2008/1082/.

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Hu, Yaogang. "Design and Synthesis of Bioactive Peptidomimetics." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5504.

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Protein-Protein Interactions (PPIs) play a very important role in biological functions and therefore the inhibition of specific Protein-Protein Interactions has a huge therapeutic value. The most successful small molecular PPIs inhibitors do not fit with the prevalent `Rule of Five' drug profile. To overcome the disadvantages of small molecular PPIs inhibitors, peptide based PPIs inhibitors were developed. Herein we describe the development of a new class of peptidomimetics AA-peptides. The AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides that are resistant to proteolysis and capable of mimicking peptides. Two types of AApeptides were discussed in this dissertation "α-AApeptides" and "γ-AApeptides". The AApeptides were shown to disrupt p53/MDM2 protein-protein interaction and tomimic fMLF tripeptide to target G protein-coupled formyl peptide receptors (FPRs). Moreover, the lipidated α-AApeptides can mimic the structure and function of natural antimicrobial lipopeptides and show broad-spectrum activity against both Gram-positive and Gram-negative bacteria. Lastly I have designed and synthesized a serials of phosphopeptides to disrupt cancer related STAT3-STAT3 dimerization.
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Tyrrell, Andrew J. "Approaches to the synthesis of bioactive pyrrolizidines." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497131.

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Miranda, Vanessa. "Synthesis of new bioactive autoinducer-2 analogues." Doctoral thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2019. http://hdl.handle.net/10362/94059.

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" Bacteria behaviours are regulated on a community­wide scale by producing,  secreting,  detecting  and  responding  to  extracellular  small  signaling  molecules  (autoinducers)  that accumulate in the environment in proportion to cell density.  This process is called quorum sensing (QS).  (...)"
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Isoni, Valerio. "Asymmetric synthesis of bioactive alkaloids from Amaryllidaceae." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/355712/.

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A new route towards the diasteroselective synthesis of (+)-maritidine, a bioactive alkaloid from Amaryllidaceae, has been proposed. In our approach, an intramolecular Heck reaction was used to form the quaternary stereocentre C10b driven by the stereochemical information at C4a of the precursor. Allylic oxidation of intermediate 3.25 followed by diasteroselective reduction, introduced the alcohol at C3 with the correct stereochemistry. An advanced intermediate (3.29) in the synthesis of (+)-maritidine was produced, and routes to complete the total synthesis were proposed. A series of polymer-supported sulfonate ester linkers were developed for use in the resin-linker-vector (RLV) approach for the synthesis of [18F]-radiopharmaceuticals used as imaging probes in positron-emission-tomography (PET). Upon exposure of the RLV construct to [18F]-fluoride, a small quantity of [18F]-radiotracer is released in solution which is separated from the unreacted material and cleaved resin, by simple filtration. The RLV strategy was successfully applied for the synthesis of the known radiopharmaceutical O-(2-[18F]-fluoroethyl)-L-tyrosine, [18F]-FET. A C-H activation-cyclisation sequence was used to achieve the synthesis of the Amaryllidaceae alkaloid oxoassoanine as well as a phenanthridinoid analogue, part of potential non-charged dual reactivators of acetylcholinesterase (AChE) poisoned by organophosphorous (OP) nerve agents.
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Soldati, Roberto <1986&gt. "Synthesis of new bioactive β-lactam compounds." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6974/1/Soldati_Roberto_Tesi.pdf.

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New biologically active β-lactams were designed and synthesized, developing novel antibiotics and enzymatic inhibitors directed toward specific targets. Within a work directed to the synthesis of mimetics for RGD (Arg-Gly-Asp) sequence able to interact with αvβ3 and α5β1-type integrins, new activators were developed and their Structure-Activity Relationships (SAR) analysis deepened, enhancing their activity range towards the α4β1 isoform. Moreover, to synthesize novel compounds active both against bacterial infections and pulmonary conditions of cystic fibrosis patients, new β-lactam candidates were studied. Among the abundant library of β-lactams prepared, mainly with antioxidant and antibacterial double activities, it was identified a single lead to be pharmacologically tested in vivo. Its synthesis was optimized up to the gram-scale, and pretreatment method and HPLC-MS/MS analytical protocol for sub-nanomolar quantifications were developed. Furthermore, replacement of acetoxy group in 4-acetoxy-azetidinone derivatives was studied with different nucleophiles and in aqueous media. A phosphate group was introduced and the reactivity exploited using different hydroxyapatites, obtaining biomaterials with multiple biological activities. Following the same kind of reactivity, a small series of molecules with a β-lactam and retinoic hybrid structure was synthesized as epigenetic regulators. Interacting with HDACs, two compounds were respectively identified as an inhibitor of cell proliferation and a differentiating agent on steam cells. Additionally, in collaboration with Professor L. De Cola at ISIS, University of Strasbourg, some new photochemically active β-lactam Pt (II) complexes were designed and synthesized to be used as bioprobes or theranostics. Finally, it was set up and optimized the preparation of new chiral proline-derived α-aminonitriles through an enantioselective Strecker reaction, and it was developed a chemo-enzymatic oxidative method for converting alcohols to aldehydes or acid in a selective manner, and amines to relative aldehydes, amides or imines. Moreover, enzymes and other green chemistry methodologies were used to prepare Active Pharmaceutical Ingredients (APIs).
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Books on the topic "Bioactive Synthesis"

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Ameta, K. L., and Anshu Dandia, eds. Green Chemistry: Synthesis of Bioactive Heterocycles. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1850-0.

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Cossy, Janine, and Stellios Arseniyadis, eds. Modern Tools for the Synthesis of Complex Bioactive Molecules. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118342886.

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Modern tools for the synthesis of complex bioactive molecules. Hoboken, N.J: Wiley, 2012.

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Kobayashi, Yuichi, ed. Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-6244-6.

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Chuanjun, Song, ed. Wu wei zi huo xing cheng fen ji hua xue he cheng: Bioactive ingredient of schisandra chinensis and their syntheses. Hefei Shi: Zhongguo ke xue ji shu da xue chu ban she, 2012.

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Doran, Robert. Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1.

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Bonin, Geneviève Catherine. Use of water soluble pharmaceuticals in the synthesis of bioactive fluorinated surface modifiers. Ottawa: National Library of Canada, 2003.

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H, Waldmann, and Janning Petra, eds. Chemical biology: Learning through case studies. Weinheim: Wiley-VCH, 2009.

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Inuki, Shinsuke. Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds. Tokyo: Springer Tokyo, 2012. http://dx.doi.org/10.1007/978-4-431-54043-4.

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1930-, Kleinkauf Horst, and Döhren Hans von 1948-, eds. Biochemistry of peptide antibiotics: Recent advances in the biotechnology of B-lactams and microbial bioactive peptides. Berlin: W. de Gruyter, 1990.

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Book chapters on the topic "Bioactive Synthesis"

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Basmadjian, Christine, Qian Zhao, Armand de Gramont, Maria Serova, Sandrine Faivre, Eric Raymond, Stephan Vagner, Caroline Robert, Canan G. Nebigil, and Laurent Désaubry. "Bioactive Flavaglines: Synthesis and Pharmacology." In Bioactive Natural Products, 171–98. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527684403.ch7.

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Matsuzaki, Kei, Iwao Yamamoto, Koji Enomoto, Yutaro Kaneko, Tohru Mimura, and Tsuyoshi Shiio. "Synthesis of Antitumor Polysaccharides." In Applied Bioactive Polymeric Materials, 165–74. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5610-3_13.

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Ahamad, Javed, Raja Kumar Parabathina, and Javed Ahmad. "Chemical Synthesis of Peptides." In Bioactive Peptides from Food, 349–62. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003106524-22.

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Mohd Nor, Siti Mariam, Zhengshuang Xu, and Tao Ye. "Bioactive Macrocyclic Natural Products." In Heterocycles in Natural Product Synthesis, 569–619. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634880.ch16.

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Zhdanov, R. I., V. A. Sukhanov, and V. I. Shvets. "Synthesis and Properties of Spin-Labeled Phospholipids." In Bioactive Spin Labels, 297–315. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-48724-8_11.

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Ata, Athar, and Samina Naz. "Synthesis of Bioactive Heterocyclic Compounds." In Greener Synthesis of Organic Compounds, Drugs and Natural Products, 137–50. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003089162-8.

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Gharib, Ali. "Eco-Friendly Synthesis of Bioactive Heterocycles." In Green Chemistry: Synthesis of Bioactive Heterocycles, 69–104. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1850-0_3.

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Phougat, Neetu, Manish Kumar, Reena V. Saini, and Anil Kumar Chhillar. "Green Chemistry Approach Towards Nanoparticle Synthesis." In Metabolic Engineering for Bioactive Compounds, 249–68. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5511-9_12.

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Wouatsa, Nangue Arlette Vyry. "Bioactive Proteins: Source, Synthesis, and Applications." In Biomedical Applications of Natural Proteins, 79–88. New Delhi: Springer India, 2015. http://dx.doi.org/10.1007/978-81-322-2491-4_6.

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Rostamnia, Sadegh, and Esmail Doustkhah. "Synthesis and Synthetic Applications of Biologically Interesting Rhodanine and Rhodanine-Based Scaffolds." In Green Chemistry: Synthesis of Bioactive Heterocycles, 253–75. New Delhi: Springer India, 2014. http://dx.doi.org/10.1007/978-81-322-1850-0_9.

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Conference papers on the topic "Bioactive Synthesis"

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Barbosa, Flavio A. R., Rômulo F. S. Canto, and Antonio L. Braga. "Synthesis of novel 6-seleno-dihydropyrimidinones: Potentially bioactive compounds." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013819222620.

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Jayabalan, Jaya Bharathi, Senthilkumar Kandasamy, Manjula Palanisamy, Prasad Rangasamy, and Ajay Sathiya. "Bioactive phytochemicals synthesis: Source, preparation and characterization." In PROCEEDINGS OF THE 4TH NATIONAL CONFERENCE ON CURRENT AND EMERGING PROCESS TECHNOLOGIES E-CONCEPT-2021. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0068776.

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Ferreira, Samuel R. A., Jesus M. Pena, Simone C. Silva, and Giuliano C. Clososki. "Directed Functionalization of Quinoxalines Aiming the Synthesis of Bioactive Compounds." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201391317050.

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Haixia Li, Lili Bai, and Yuanyan Hu. "Chemical synthesis and bioactive research of Dihydromyricetin-manganese complex." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5966089.

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Tulaidan, Halyna, Ruslan Symchak, and Vitaliy Вaranovskyi. "APPLICATION OF ANIONARYLATION REACTION FOR SYNTHESIS OF BIOACTIVE COMPOUNDS." In SCIENTIFIC PRACTICE: MODERN AND CLASSICAL RESEARCH METHODS. European Scientific Platform, 2022. http://dx.doi.org/10.36074/logos-16.09.2022.20.

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Gonda, T., B. Ötvös Sándor, and A. Hunyadi. "Synthesis of new, potentially bioactive chalcones as protoflavone analogues." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608257.

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Wendler, Edison P., Rafaela C. Carmona, and Alcindo A. Dos Santos. "A3 Coupling Reaction as a Key Strategy in a Three-Step Synthesis of Bioactive Alkaloids." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0205-1.

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Aburatani, Yasushi, Satoshi Hayakawa, Chikara Ohtsuki, and Akiyoshi Osaka. "SYNTHESIS OF BIOACTIVE ORGANIC-INORGANIC HYBRIDS REINFORCED WITH AEROSIL®." In Proceedings of the 12th International Symposium on Ceramics in Medicine. WORLD SCIENTIFIC, 1999. http://dx.doi.org/10.1142/9789814291064_0110.

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Kim, Byeong Il, Kyoung G. Lee, Tae Jae Lee, Gle Park, Tae Jung Park, and Seok Jae Lee. "Microfluidic device for the synthesis of bioactive core-shell microcapsules." In 2011 IEEE Nanotechnology Materials and Devices Conference (NMDC 2011). IEEE, 2011. http://dx.doi.org/10.1109/nmdc.2011.6155397.

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Hammami, I., S. R. Gavinho, A. S. Padua, M. P. F. Graca, and J. C. Silva. "Synthesis and Characterization of Iron Containing Bioactive Glass for Implants." In 2022 E-Health and Bioengineering Conference (EHB). IEEE, 2022. http://dx.doi.org/10.1109/ehb55594.2022.9991451.

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