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Journal articles on the topic 'Bioactive Lactones'

Author: Grafiati

Published: 6 September 2023

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1

Shen, Ya-Ching, Kuang-Liang Lo, Yao Haur Kuo, and Ashraf Taha Khalil. "Bioactive Sesquiterpene Lactones from Eupatorium Kiirunense." Natural Product Communications 1, no. 7 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100703.

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Four new sesquiterpene lactones, two heliangolides, one eudesmanolide and one germacranolide, were isolated by chromatographic fractionation of an acetone extract of Eupatorium kiirunense and named eupakirunsins F, G H and I (1–4). They were identified as 8β-(3-hydroxy-2-methylen-butanoyloxy)-1β,10α-epoxy-3α-hydroxy-6βH,7αH-heliang-4Z,11(13)-dien-6,12-olide (1), 8β-tigloyloxy-1β,10α-epoxy-3β,15-dihydroxy-6βH,7αH-heliang-4Z,11(13)-dien-6,12-olide (2), 8β-tigloyloxy-1 β,3β-dihydroxy-6βH,7αH-eudesman-4(15),11(13)-dien-6,12-olide (3) and 8βtigloyloxy-3βhydroxy-1β,10β-epoxy-14-oxo-6βH,7αH-germacra-

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2

Bokić, Jelena, Jovana Kojić, Jelena Krulj, et al. "Bioactive, Mineral and Antioxidative Properties of Gluten-Free Chicory Supplemented Snack: Impact of Processing Conditions." Foods 11, no. 22 (2022): 3692. http://dx.doi.org/10.3390/foods11223692.

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This study aimed to investigate the impact of chicory root addition (20–40%) and extrusion conditions (moisture content from 16.3 to 22.5%, and screw speed from 500 to 900 rpm) on bioactive compounds content (inulin, sesquiterpene lactones, and polyphenols) of gluten-free rice snacks. Chicory root is considered a potential carrier of food bioactives, while extrusion may produce a wide range of functional snack products. The mineral profiles were determined in all of the obtained extrudates in terms of Na, K, Ca, Mg, Fe, Mn, Zn, and Cu contents, while antioxidative activity was established thro

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3

Mandal, Sudip Kumar, Utsab Debnath, Amresh Kumar, et al. "Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect." Letters in Drug Design & Discovery 17, no. 9 (2020): 1102–16. http://dx.doi.org/10.2174/1570180817999200421144007.

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Background and Introduction: Sesquiterpene lactones are a class of secondary metabolite that contains sesquiterpenoids and lactone ring as pharmacophore moiety. A large group of bioactive secondary metabolites such as phytopharmaceuticals belong to this category. From the Asteraceae family-based medicinal plants, more than 5,000 sesquiterpene lactones have been reported so far. Sesquiterpene lactone-based pharmacophore moieties hold promise for broad-spectrum biological activities against cancer, inflammation, parasitic, bacterial, fungal, viral infection and other functional disorders. Moreov

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Yang, Sien-Sing, Guei-Jane Wang, Kuo-Fang Cheng та ін. "Bioactive γ-Lactones from the Fermented Broth ofNeosartoryasp." Planta Medica 76, № 15 (2010): 1701–5. http://dx.doi.org/10.1055/s-0030-1249907.

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5

Bai, Lu, Mi Jiang, Sen Guo, et al. "Simultaneous quantification of six sesquiterpene lactones and a flavonoid in the whole life stage of Inula salsoloides by high performance liquid chromatography." Analytical Methods 8, no. 17 (2016): 3587–91. http://dx.doi.org/10.1039/c6ay00257a.

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6

Stojanović, Milica, Slađana Savić, Abigaël Delcourt, et al. "Phenolics and Sesquiterpene Lactones Profile of Red and Green Lettuce: Combined Effect of Cultivar, Microbiological Fertiliser, and Season." Plants 12, no. 14 (2023): 2616. http://dx.doi.org/10.3390/plants12142616.

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The main goal of our study was to find an optimal combination of tested factors to achieve lettuce rich in bioactive compounds sustaining its pleasant taste. We examined three red and three green cultivars in a greenhouse using two microbiological fertilisers (EM Aktiv and Vital Tricho), and their combination. Plants were grown in three consecutive growing seasons (autumn, winter, and spring). Lactones accumulated in autumn, whereas phenolics’ concentration rose during winter. Red cultivars showed higher phenolics and lactone content, where chicoric acid and luteolin-7-glucoside were the most

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7

Maksymiak, Magdalena, Tomasz Bałakier, Janusz Jurczak, Marek Kowalczuk, and Grazyna Adamus. "Bioactive (co)oligoesters with antioxidant properties – synthesis and structural characterization at the molecular level." RSC Advances 6, no. 62 (2016): 57751–61. http://dx.doi.org/10.1039/c6ra09870c.

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8

Erasto, P., D. S. Grierson, and A. J. Afolayan. "Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina." Journal of Ethnopharmacology 106, no. 1 (2006): 117–20. http://dx.doi.org/10.1016/j.jep.2005.12.016.

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9

Lu, X., G. Zhu, Z. Wang, S. Ma, J. Ji, and Z. Zhang. "Enyne cyclization methodology for the synthesis of bioactive lactones." Pure and Applied Chemistry 69, no. 3 (1997): 553–58. http://dx.doi.org/10.1351/pac199769030553.

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10

Ren, Qiao, Shaofa Sun, Jiayao Huang та ін. "An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones". Chem. Commun. 50, № 46 (2014): 6137–40. http://dx.doi.org/10.1039/c4cc01736f.

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Chiral saturated δ-lactones, ubiquitous bioactive O-heterocycles in nature, are readily prepared via a direct enantioselective decarboxylation of α,β-unsaturated carbonyls and malonic half-thioesters.

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11

Reda, Eman H., Nesrine M. Hegazi, Mona Marzouk, et al. "Feature-Based Molecular Networking for the Exploration of the Metabolome Diversity of Common Egyptian Centaurea Species in Relation to Their Cytotoxic Activity." Molecules 28, no. 2 (2023): 674. http://dx.doi.org/10.3390/molecules28020674.

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Centaurea is a genus compromising over 250 herbaceous flowering species and is used traditionally to treat several ailments. Among the Egyptian Centaurea species, C. lipii was reported to be cytotoxic against multidrug-resistant cancer cells. In this context, we aimed to explore the metabolome of C. lipii and compare it to other members of the genus in pursuance of identifying its bioactive principles. An LC-MS/MS analysis approach synchronized with feature-based molecular networks was adopted to offer a holistic overview of the metabolome diversity of the Egyptian Centaurea species. The studi

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12

Li, Chao, Alexander X. Jones, and Xiaoguang Lei. "Synthesis and mode of action of oligomeric sesquiterpene lactones." Natural Product Reports 33, no. 5 (2016): 602–11. http://dx.doi.org/10.1039/c5np00089k.

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In this highlight we describe two case studies from our laboratory, involving the biomimetic syntheses and the biological mechanism elucidation of the bioactive oligomeric sesquiterpenoids, (+)-ainsliadimer A (4) and (−)-ainsliatrimer A (5).

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13

Kim, Dae Yong, and Bu Young Choi. "Costunolide—A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential." International Journal of Molecular Sciences 20, no. 12 (2019): 2926. http://dx.doi.org/10.3390/ijms20122926.

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Sesquiterpene lactones constitute a major class of bioactive natural products. One of the naturally occurring sesquiterpene lactones is costunolide, which has been extensively investigated for a wide range of biological activities. Multiple lines of preclinical studies have reported that the compound possesses antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Many of these bioactivities are supported by mechanistic details, such as the modulation of various intracellular signaling pathways involved

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14

Bai, Meng, Guo-Lei Huang, Rong-Qing Mei, et al. "Bioactive Lactones from the Mangrove-Derived Fungus Penicillium sp. TGM112." Marine Drugs 17, no. 8 (2019): 433. http://dx.doi.org/10.3390/md17080433.

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Three new lactones penicilactones A−C (1−3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo2(OAc)4-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 μg/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC50 value of 78.5 (±0.58) μg/mL.

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15

Sultana, N., A. J. Afolayan, and P. J. Houghton. "Bioactive sesquiterpene lactones isolated from the shoots of Arctotis arctotoides." South African Journal of Botany 69, no. 2 (2003): 158–60. http://dx.doi.org/10.1016/s0254-6299(15)30339-2.

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16

Youn, Ui Joung, Gabriella Miklossy, Xingyun Chai, et al. "Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea." Fitoterapia 93 (March 2014): 194–200. http://dx.doi.org/10.1016/j.fitote.2013.12.013.

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17

Xiao, Jian, Guangming Nan, Ya-Wen Wang та Yu Peng. "Concise Synthesis of (+)-β- and γ-Apopicropodophyllins, and Dehydrodesoxypodophyllotoxin". Molecules 23, № 11 (2018): 3037. http://dx.doi.org/10.3390/molecules23113037.

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Herein, we present an expeditous synthesis of bioactive aryldihydronaphthalene lignans (+)-β- and γ-apopicropodophyllins, and arylnaphthalene lignan dehydrodesoxypodophyllotoxin. The key reaction is regiocontrolled oxidations of stereodivergent aryltetralin lactones, which were easily accessed from a nickel-catalyzed reductive cascade approach developed in our group.

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18

Rocchetti, Gabriele, Luigi Lucini, Giandomenico Corrado, et al. "Phytochemical Profile, Mineral Content, and Bioactive Compounds in Leaves of Seed-Propagated Artichoke Hybrid Cultivars." Molecules 25, no. 17 (2020): 3795. http://dx.doi.org/10.3390/molecules25173795.

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The globe artichoke (Cynara cardunculus L. subsp. Scolymus (L.) Hegi) is a multi-year species rich in various classes of phytochemicals with known nutritional and pharmacological properties, such as polyphenols, sesquiterpene lactones, and terpenoids. Over the last decade, hybrids cultivars are transforming the artichoke market for their higher uniformity and stability over the traditional landraces, further increasing the potential of the artichoke as a source of commercial extracts and bioactive molecules. Our aim was to investigate the mineral and phytochemical profiles of leaves from seven

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19

Phan, Minh Giang, Thi Thao Do, Thi Nga Nguyen, Thi Viet Huong Do, Ngoc Phuc Dong, and Minh Trang Vu. "Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells." Evidence-Based Complementary and Alternative Medicine 2021 (May 18, 2021): 1–12. http://dx.doi.org/10.1155/2021/6610347.

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Eupatorium japonicum Thunb. of the plant family Asteraceae is a popular traditional herb in Vietnam. However, its chemical constituents as well as bioactive principles have not been investigated yet. We investigated the phytochemistry of E. japonicum in Vietnam and isolated seventeen compounds (1–17) including phytosterols, terpenoids, phenolic acids, flavonoids, fatty alcohols, and fatty acids. They were structurally determined by MS and NMR analysis. Except for compounds 6 and 12, all the other compounds were identified for the first time from E. japonicum. Since many sesquiterpene lactones

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20

Zhang, Mengke, Xi Yang, Yanzhang Wei, et al. "Bioactive Sesquiterpene Lactones Isolated from the Whole Plants of Vernonia cinerea." Journal of Natural Products 82, no. 8 (2019): 2124–31. http://dx.doi.org/10.1021/acs.jnatprod.8b01078.

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21

Zhang, Sheng, Fei Lian, Mengyu Xue, et al. "Electrocatalytic Dehydrogenative Esterification of Aliphatic Carboxylic Acids: Access to Bioactive Lactones." Organic Letters 19, no. 24 (2017): 6622–25. http://dx.doi.org/10.1021/acs.orglett.7b03333.

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22

LU, X., S. MA, J. JI, G. ZHU, Z. WAN, and Z. ZHANG. "ChemInform Abstract: Enyne Cyclization Methodology for the Synthesis of Bioactive Lactones." ChemInform 28, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199725290.

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23

LU, X., G. ZHU, Z. WANG, S. MA, J. JI, and Z. ZHANG. "ChemInform Abstract: Enyne Cyclization Methodology for the Synthesis of Bioactive Lactones." ChemInform 28, no. 28 (2010): no. http://dx.doi.org/10.1002/chin.199728251.

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24

Goossens, Laurence, Omar Castillo-Aguilera, Patrick Depreux, Alexia Ballée, Florian Beaurain, and Paola B. Arimondo. "Study of the Effect of Substituents of ortho-Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines." Synlett 31, no. 12 (2020): 1216–20. http://dx.doi.org/10.1055/s-0040-1707112.

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Benzimidazoles represent common chemical moieties in bioactive compounds. The synthesis of this heterocycle often involves a condensation of an ortho-phenylenediamine with a carboxylic acid derivative. The observed dialkylation of the starting ortho-phenylenediamine is avoided by opening of lactones or lactams. This strategy can directly yield 1H-benzimidazoles substituted at the 2-position by a functionalized chain. We present herein a study of the effect of different electron-withdrawing or electron-donating groups at the 4-position of ortho-phenylenediamines on the opening of lactones or la

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25

Kebbi, Sara, Maria Letizia Ciavatta, Ali Mokhtar Mahmoud, et al. "Sesquiterpene Lactones with the 12,8-Guaianolide Skeleton from Algerian Centaurea omphalotricha." Biomolecules 11, no. 7 (2021): 1053. http://dx.doi.org/10.3390/biom11071053.

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In continuing our investigation on the chemical diversity of Algerian plants, we examined Centaurea omphalotricha, whose chemical composition has been poorly studied. The present work was aimed at characterizing the secondary metabolite pattern of the CHCl3 extract of the aerial parts of this plant that displayed antiproliferative properties in a preliminary screening on HeLa cell line. The chemical analysis led us to characterize the bioactive oxygenated terpenoid fraction which includes, within major known metabolites, two new minor sesquiterpene lactones, centaurolide-A (1) and centaurolide

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26

Jürgens, Franziska M., Fabian C. Herrmann, Sara M. Robledo, and Thomas J. Schmidt. "Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture." Pharmaceutics 14, no. 4 (2022): 742. http://dx.doi.org/10.3390/pharmaceutics14040742.

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Arnica tincture is a traditional herbal medicine used to treat blunt injuries, e.g., bruises and squeezes. In addition, a potential new use in the treatment of cutaneous leishmaniasis is currently under investigation. Therefore, detailed information about the dermal absorption of the tincture and especially its bioactive constituents, sesquiterpene lactones (STLs) of the helenalin- and 11α,13-dihydrohelenalin type, is mandatory. Consequently, this article reports on dermal absorption studies of Arnica tincture using diffusion cells and porcine skin as well as two human skin samples with differ

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27

Sülsen, Valeria P. "Sesquiterpene Lactones and Diterpenes: Promising Therapeutic Candidates for Infectious Diseases, Neoplasms and Other Chronic Disorders." Molecules 26, no. 5 (2021): 1251. http://dx.doi.org/10.3390/molecules26051251.

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28

Sriramaneni, RaghavaN, Amirin Sadikun, NaveenKumar Hawala Shivashekaregowda, Annegowda Venkatappa, and MohamadZaini Asmawi. "Identification of bioactive diterpenoid lactones using nuclear magnetic resonance from Andrographis paniculata." Pharmacognosy Research 11, no. 2 (2019): 121. http://dx.doi.org/10.4103/pr.pr_117_18.

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29

Häkkinen, Suvi T., Marina Soković, Liisa Nohynek, et al. "Chicory Extracts and Sesquiterpene Lactones Show Potent Activity against Bacterial and Fungal Pathogens." Pharmaceuticals 14, no. 9 (2021): 941. http://dx.doi.org/10.3390/ph14090941.

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Chicory (Cichorium intybus L.) is an important industrial crop cultivated mainly to extract the dietary fiber inulin. However, chicory also contains bioactive compounds such as sesquiterpene lactones and certain polyphenols, which are currently discarded as waste. Plants are an important source of active pharmaceutical ingredients, including novel antimicrobials that are urgently needed due to the global spread of drug-resistant bacteria and fungi. Here, we tested different extracts of chicory for a range of bioactivities, including antimicrobial, antifungal and cytotoxicity assays. Antibacter

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30

Lin, Y., K. Lou, G. Wu, et al. "Bioactive metabolites in of Ginkgo biloba leaves: variations by seasonal, meteorological and soil." Brazilian Journal of Biology 80, no. 4 (2020): 790–97. http://dx.doi.org/10.1590/1519-6984.220519.

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Abstract Ginkgo biloba is a traditional Chinese herbal medicine containing multiple components that contribute to its notable bioactivities. Variations of seasonal, meteorological and planting soil on the phytochemicals contents in G. biloba leaves due to the effects of growth meteorological and soil parameters were investigated in this study. The leaves of G. biloba were collected from different months and place in Zhejiang province, the contents of flavones (quercetin, kaempferol and isorhamnetin) and terpene lactones (bilobalide, ginkgolides A, B and C) were quantified by high performance l

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31

Ivanescu, Bianca, Cristina Lungu, Laurian Vlase, Ana Maria Gheldiu, Cristina Grigorescu, and Andreia Corciova. "Bioactive Compounds from Artemisia campestris L. Subsp. Campestris." Revista de Chimie 69, no. 11 (2018): 3076–81. http://dx.doi.org/10.37358/rc.18.11.6686.

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Artemisia campestris L. (field wormwood) is a known medicinal plant used mainly in Asian medicine and most often overlooked in the western world, despite its cosmopolitan distribution. The aim of this study was to investigate the phytochemical composition of A. campestris from Romanian spontaneous flora in order to determine the bioactive molecules and to assess the antioxidant effect of the plant extract. For this purpose, we applied LC-MS methods for the analysis of phytosterols and polyphenols and developed new methods for the analysis of methoxylated flavones and sesquiterpene lactones, sp

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32

Singh, Meenakshi, V. Ravichandiran, Yogesh P. Bharitkar, and Abhijit Hazra. "Natural Products Containing Olefinic Bond: Important Substrates for Semi-synthetic Modification Towards Value Addition." Current Organic Chemistry 24, no. 7 (2020): 709–45. http://dx.doi.org/10.2174/1385272824666200312125734.

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: Semi-synthesis, the way of preparing novel bioactive molecules via modification of compounds isolated from natural sources is very much useful nowadays in the drug discovery process. The modification is based on the reaction of functional group(s) present in a natural compound. Among the examples of functional group transformation, double bond modification is also common in the literature. Several reactions like hydrogenation, cyclopropanation, epoxidation, addition reaction (halogenations, hydroxylation), Michael addition, Heck reaction, cycloaddition, dipolar cycloaddition, etc. are employ

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33

Ingallina, Cinzia, Giacomo Di Matteo, Mattia Spano, et al. "Byproducts of Globe Artichoke and Cauliflower Production as a New Source of Bioactive Compounds in the Green Economy Perspective: An NMR Study." Molecules 28, no. 3 (2023): 1363. http://dx.doi.org/10.3390/molecules28031363.

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The recovery of bioactive compounds from crop byproducts leads to a new perspective way of waste reutilization as a part of the circular economy. The present study aimed at an exhaustive metabolite profile characterization of globe artichoke and cauliflower byproducts (leaves, stalks, and florets for cauliflower only) as a prerequisite for their valorization and future implementations. The metabolite profile of aqueous and organic extracts of byproducts was analyzed using the NMR-based metabolomics approach. Free amino acids, organic acids, sugars, polyols, polyphenols, amines, glucosinolates,

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34

Engels, Nora S., Barbara Gierlikowska, Birgit Waltenberger, Fang-Rong Chang, Anna K. Kiss, and Hermann Stuppner. "A New Diterpene and Anti-inflammatory Sesquiterpene Lactones from Sigesbeckia orientalis." Planta Medica 86, no. 15 (2020): 1108–17. http://dx.doi.org/10.1055/a-1232-6869.

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Abstract Sigesbeckia orientalis, more commonly referred to as Herba Sigesbeckiae or Xi Xian Cao in traditional Chinese medicine and hy thiêm in traditional Vietnamese medicine, is used in China and Vietnam to treat inflammatory diseases such as arthritis, rheumatism, and joint pain. In initial investigations, the dichloromethane extract from the aerial parts of S. orientalis showed distinct inhibitory effects on the release of interleukin-8 in human neutrophils. Therefore, the purpose of the present study was the phytochemical investigation of the bioactive dichloromethane extract and the in v

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35

Hordiei, Karyna, Tetiana Gontova, Sonata Trumbeckaite, Maksym Yaremenko, and Lina Raudone. "Phenolic Composition and Antioxidant Activity of Tanacetum parthenium Cultivated in Different Regions of Ukraine: Insights into the Flavonoids and Hydroxycinnamic Acids Profile." Plants 12, no. 16 (2023): 2940. http://dx.doi.org/10.3390/plants12162940.

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Tanacetum parthenium, also known as feverfew, is rich in bioactive compounds, namely sesquiterpene lactones, flavonoids, and volatile oils. Sesquiterpene lactones possess anti-migraine activity, while phenolic compounds possess anti-inflammatory and antioxidant action. Phytochemical composition determines the pharmacological activity and so profiling is essential in quality assessment. The study aimed to evaluate cultivated feverfew plants’ phenolic profiles and antioxidant activity. Eleven phenolic compounds were identified in the samples of feverfew in Ukraine. Hydroxycinnamic acids predomin

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36

Matos, Melanie S., José D. Anastácio, and Cláudia Nunes dos Santos. "Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation." Pharmaceutics 13, no. 7 (2021): 991. http://dx.doi.org/10.3390/pharmaceutics13070991.

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Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage. Sesquiterpene lactones (SLs) are composed of a large and diverse group of highly bioactive plant secondary metabolites, characterized by a 15-carbon backbone structure. In recent years, the interest in SLs has risen due to their vast array of biological activities beneficial for human health. The anti-inflammatory potential of these compounds results from their

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37

Niego, Allen Grace, Olivier Raspé, Naritsada Thongklang, et al. "Taxonomy, Diversity and Cultivation of the Oudemansielloid/Xeruloid Taxa Hymenopellis, Mucidula, Oudemansiella, and Xerula with Respect to Their Bioactivities: A Review." Journal of Fungi 7, no. 1 (2021): 51. http://dx.doi.org/10.3390/jof7010051.

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The oudemansielloid/xeruloid taxa Hymenopellis, Mucidula, Oudemansiella, and Xerula are genera of Basidiomycota that constitute an important resource of bioactive compounds. Numerous studies have shown antimicrobial, anti-oxidative, anti-cancer, anti-inflammatory and other bioactivities of their extracts. The bioactive principles can be divided into two major groups: (a) hydrophilic polysaccharides with relatively high molecular weights and (b) low molecular medium polar secondary metabolites, such as the antifungal strobilurins. In this review, we summarize the state of the art on biodiversit

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38

Kumar, Krishan, Rahul Mehra, Raquel P. F. Guiné, et al. "Edible Mushrooms: A Comprehensive Review on Bioactive Compounds with Health Benefits and Processing Aspects." Foods 10, no. 12 (2021): 2996. http://dx.doi.org/10.3390/foods10122996.

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Mushrooms are well-known functional foods due to the presence of a huge quantity of nutraceutical components. These are well recognized for their nutritional importance such as high protein, low fat, and low energy contents. These are rich in minerals such as iron, phosphorus, as well as in vitamins like riboflavin, thiamine, ergosterol, niacin, and ascorbic acid. They also contain bioactive constituents like secondary metabolites (terpenoids, acids, alkaloids, sesquiterpenes, polyphenolic compounds, lactones, sterols, nucleotide analogues, vitamins, and metal chelating agents) and polysacchar

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Cheng, Xiang-Rong, Wen-Hao Shao, Shou-De Zhang, et al. "Winolides A–C, bioactive sesquiterpene lactones with unusual 5,6-secoeudesmane frameworks from Inula wissmanniana." RSC Advances 4, no. 64 (2014): 33815. http://dx.doi.org/10.1039/c4ra05131a.

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40

Wang, Kai, Li Bao, Ke Ma, et al. "Bioactive Spirobisnaphthalenes and Lactones from a Cup FungusPlectaniasp. Collected in the Tibet Plateau Region." European Journal of Organic Chemistry 2016, no. 25 (2016): 4338–46. http://dx.doi.org/10.1002/ejoc.201600562.

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Su, Miaoxian, Xia Wu, Hau Yin Chung, Yaolan Li, and Wencai Ye. "Antiproliferative Activities of Five Chinese Medicinal Herbs and Active Compounds in Elephantopus scaber." Natural Product Communications 4, no. 8 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400802.

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Extracts and fractions prepared from five medicinal herbs used to treat cancer in Chinese folk medicine were tested for their antiproliferative activities on five cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The MTT results revealed that the ethanolic extracts possessed stronger antiproliferative activities than the corresponding aqueous ones. The bioactive fractions of the ethanolic extracts were mostly found in n-hexane and/or ethyl acetate fractions, which by TLC analysis were shown to contain terpenes and/or phenolic compounds. The

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Silva, Luís R., Telma A. Jacinto, and Paula Coutinho. "Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders." Foods 11, no. 3 (2022): 336. http://dx.doi.org/10.3390/foods11030336.

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Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of

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Sary, Hanan G., Nahla A. Ayoub, Abdel Nasser B. Singab, Mickey Vinodh, and Khaled Y. Orabi. "ISOLATION OF BIOACTIVE COMPOUNDS FROM CENTAUREA AEGYPTIACA." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 4 (2018): 1. http://dx.doi.org/10.22159/ijpps.2018v10i4.17528.

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Objective: In a previous study, Centaurea aegyptiaca ethanol and ethyl acetate extracts showed potent cytotoxic effects against laryngeal (HEP2) and hepatic (HEPG2) carcinoma cell lines. Additionally, two novel compounds were isolated and identified. The aim of this study is to continue isolating and identifying another compound (s) that may, also, be responsible for this potent biological activity.Methods: C. aegyptiaca dried aerial parts were extracted with ethanol and ethyl acetate. Both extracts were chromatographed separately to afford seven guaianolides that were identified using differe

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Colonna, E., Y. Rouphael, G. Barbieri, and S. De Pascale. "Microbial-based biostimulants modulate antioxidant activity, bioactive compounds and sesquiterpene lactones profile of globe artichoke." Acta Horticulturae, no. 1320 (August 2021): 421–28. http://dx.doi.org/10.17660/actahortic.2021.1320.56.

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Zhang, Xiao-Yan, Zhan-Liang Liu, Bing-Da Sun, et al. "Bioactive Resorcylic Acid Lactones with Different Ring Systems from Desert Plant Endophytic Fungus Chaetosphaeronema hispidulur." Journal of Agricultural and Food Chemistry 66, no. 34 (2018): 8976–82. http://dx.doi.org/10.1021/acs.jafc.8b02648.

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Taler-Verčič, Ajda, Marko Goličnik, and Aljoša Bavec. "The Structure and Function of Paraoxonase-1 and Its Comparison to Paraoxonase-2 and -3." Molecules 25, no. 24 (2020): 5980. http://dx.doi.org/10.3390/molecules25245980.

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Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases (PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and paraoxonase activity. PON1 and its isoforms play an important role in drug metabolism as well as in the prevention of cardiovascular and neurodegenerative diseases. Although all three members of the PON family have the same origin and very similar amino acid sequences, they have different functions and are found in different locations. PONs exhibit substrate promiscuity, and their true physiological substrates are still not kn

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Wang, Yifei, Xiaowen Yang, Yanjing Li, Bo Wang, and Ting Shi. "The Genus Chrysosporium: A Potential Producer of Natural Products." Fermentation 9, no. 1 (2023): 76. http://dx.doi.org/10.3390/fermentation9010076.

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Chrysosporium, a genus of ascomycete fungi in the family Onygenaceae, has the ability to produce abundant new bioactive natural products, providing a structural foundation in drug development. This review includes the sources, distribution, biological activities and structural characteristics of the compounds isolated from Chrysosporium from 1984 to 2021. The results show that 66% of the compounds isolated from Chrysosporium are new natural products. More than half of the Chrysosporium-isolated compounds are from marine-derived Chrysosporium. The chemical structures of Chrysosporium-derived co

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Moghadamtousi, Soheil Zorofchian, Muhamad Noor Alfarizal Kamarudin, Chim Kei Chan, Bey Hing Goh, and Habsah Abdul Kadir. "Phytochemistry and Biology of Loranthus parasiticus Merr, a Commonly Used Herbal Medicine." American Journal of Chinese Medicine 42, no. 01 (2014): 23–35. http://dx.doi.org/10.1142/s0192415x14500025.

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Loranthus parasiticus Merr (L. parasiticus) is a member of Loranthaceae family and is an important medicinal plant with a long history of Chinese traditional use. L. parasiticus, also known as Sang Ji Sheng (in Chinese), benalu teh (in Malay) and baso-kisei (in Japanese), is a semiparasitic plant, which is mostly distributed in the southern and southwestern regions of China. This review aims to provide a comprehensive overview of the ethnomedicinal use, phytochemistry and pharmacological activity of L. parasiticus and to highlight the needs for further investigation and greater global developm

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Bukvicki, Danka, Miroslav Novakovic, Tatjana Ilic-Tomic, et al. "Biotransformation of Perrottetin F by Aspergillus niger: New Bioactive Secondary Metabolites." Records of Natural Products 15, no. 4 (2021): 281–92. http://dx.doi.org/10.25135/rnp.215.20.09.1812.

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Biotransformation of bis-bibenzyl perrottetin F (1), isolated from the liverwort Lunularia cruciata by Aspergillus niger, has been investigated. New metabolites (2-4) have been isolated using reversed phase semipreparative HPLC and their structures were established to be 8-hydroxyperrottetin F, C-7-C-8 cleaved product, and perrottetin F 6’-sulfate using 1D and 2D NMR, HR-ESI-MS, IR and UV spectroscopy. The antimicrobial and cytotoxic properties of these compounds were also evaluated. Given the suggested cytotoxic properties of the parent compound, antiproliferative activity against healthy hum

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Chamoli, Madhusudan, V. K. Varshney, P. K. Srivastava, Rajiv Pandey, and Rameshwar Dayal. "TLC-DENSITOMETRIC EVALUATION OF THREE MAJOR BIOACTIVE DITERPENE LACTONES IN ANDROGRAPHIS PANICULATA INTERCROPPED WITH MORUS ALBA." Journal of Liquid Chromatography & Related Technologies 37, no. 16 (2014): 2258–74. http://dx.doi.org/10.1080/10826076.2013.830268.

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