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Academic literature on the topic 'Bioactive Lactones'

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Published: 6 September 2023

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Journal articles on the topic "Bioactive Lactones"

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Shen, Ya-Ching, Kuang-Liang Lo, Yao Haur Kuo, and Ashraf Taha Khalil. "Bioactive Sesquiterpene Lactones from Eupatorium Kiirunense." Natural Product Communications 1, no. 7 (July 2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100703.

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Four new sesquiterpene lactones, two heliangolides, one eudesmanolide and one germacranolide, were isolated by chromatographic fractionation of an acetone extract of Eupatorium kiirunense and named eupakirunsins F, G H and I (1–4). They were identified as 8β-(3-hydroxy-2-methylen-butanoyloxy)-1β,10α-epoxy-3α-hydroxy-6βH,7αH-heliang-4Z,11(13)-dien-6,12-olide (1), 8β-tigloyloxy-1β,10α-epoxy-3β,15-dihydroxy-6βH,7αH-heliang-4Z,11(13)-dien-6,12-olide (2), 8β-tigloyloxy-1 β,3β-dihydroxy-6βH,7αH-eudesman-4(15),11(13)-dien-6,12-olide (3) and 8βtigloyloxy-3βhydroxy-1β,10β-epoxy-14-oxo-6βH,7αH-germacra-4E,11(13)-dien-6,12-olide (4). The structures and the relative configurations of the new metabolites were elucidated through extensive spectral analysis and by comparison with known spectral data. Among the isolated compounds, 1 and 3 exhibited potent cytotoxicity against WiDr and MCF-7 human tumor cell lines.
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Bokić, Jelena, Jovana Kojić, Jelena Krulj, Lato Pezo, Vojislav Banjac, Vesna Tumbas Šaponjac, Vanja Travičić, Diego A. Moreno, and Marija Bodroža-Solarov. "Bioactive, Mineral and Antioxidative Properties of Gluten-Free Chicory Supplemented Snack: Impact of Processing Conditions." Foods 11, no. 22 (November 17, 2022): 3692. http://dx.doi.org/10.3390/foods11223692.

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This study aimed to investigate the impact of chicory root addition (20–40%) and extrusion conditions (moisture content from 16.3 to 22.5%, and screw speed from 500 to 900 rpm) on bioactive compounds content (inulin, sesquiterpene lactones, and polyphenols) of gluten-free rice snacks. Chicory root is considered a potential carrier of food bioactives, while extrusion may produce a wide range of functional snack products. The mineral profiles were determined in all of the obtained extrudates in terms of Na, K, Ca, Mg, Fe, Mn, Zn, and Cu contents, while antioxidative activity was established through reducing capacity, DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) tests. Chicory root addition contributed to the improvement of bioactive compounds and mineral contents, as well as antioxidative activities in all of the investigated extrudates in comparison to the pure-rice control sample. An increase in moisture content raised sesquiterpene lactones and minerals, while high screw speeds positively affected polyphenols content. The achieved results showed the important impact of the extrusion conditions on the investigated parameters and promoted chicory root as an attractive food ingredient in gluten-free snack products with high bioactive value.
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Mandal, Sudip Kumar, Utsab Debnath, Amresh Kumar, Sabu Thomas, Subhash Chandra Mandal, Manabendra Dutta Choudhury, and Partha Palit. "Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect." Letters in Drug Design & Discovery 17, no. 9 (September 11, 2020): 1102–16. http://dx.doi.org/10.2174/1570180817999200421144007.

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Background and Introduction: Sesquiterpene lactones are a class of secondary metabolite that contains sesquiterpenoids and lactone ring as pharmacophore moiety. A large group of bioactive secondary metabolites such as phytopharmaceuticals belong to this category. From the Asteraceae family-based medicinal plants, more than 5,000 sesquiterpene lactones have been reported so far. Sesquiterpene lactone-based pharmacophore moieties hold promise for broad-spectrum biological activities against cancer, inflammation, parasitic, bacterial, fungal, viral infection and other functional disorders. Moreover, these moiety based phytocompounds have been highlighted with a new dimension in the natural drug discovery program worldwide after the 2015 Medicine Nobel Prize achieved by the Artemisinin researchers. Objective: These bitter substances often contain an α, β-unsaturated-γ-lactone as a major structural backbone, which in recent studies has been explored to be associated with anti-tumor, cytotoxic, and anti-inflammatory action. Recently, the use of sesquiterpene lactones as phytomedicine has been increased. This study will review the prospect of sesquiterpene lactones against inflammation and cancer. Methods: Hence, we emphasized on the different features of this moiety by incorporating its structural diversity on biological activities to explore structure-activity relationships (SAR) against inflammation and cancer. Results: How the dual mode of action such as anti-inflammatory and anti-cancer has been exhibitedby these phytopharmaceuticals will be forecasted in this study. Furthermore, the correlation of anti-inflammatory and anti-cancer activity executed by the sesquiterpene lactones for fruitful phytotherapy will also be revealed in the present review in the milieu of pharmacophore activity relation and pharmacodynamics study as well. Conclusion: So, these metabolites are paramount in phytopharmacological aspects. The present discussion on the future prospect of this moiety based on the reported literature could be a guide for anti-inflammatory and anti-cancer drug discovery programs for the upcoming researchers.
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Yang, Sien-Sing, Guei-Jane Wang, Kuo-Fang Cheng, Chu-Huang Chen, Yu-Ming Ju, Ya-Jing Tsau, and Tzong-Huei Lee. "Bioactive γ-Lactones from the Fermented Broth ofNeosartoryasp." Planta Medica 76, no. 15 (May 5, 2010): 1701–5. http://dx.doi.org/10.1055/s-0030-1249907.

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Bai, Lu, Mi Jiang, Sen Guo, Qingchao Liu, Xinxin Zhang, Xiao Tian, Li Zhang, Chi-Tang Ho, and Naisheng Bai. "Simultaneous quantification of six sesquiterpene lactones and a flavonoid in the whole life stage of Inula salsoloides by high performance liquid chromatography." Analytical Methods 8, no. 17 (2016): 3587–91. http://dx.doi.org/10.1039/c6ay00257a.

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Stojanović, Milica, Slađana Savić, Abigaël Delcourt, Jean-Louis Hilbert, Philippe Hance, Jelena Dragišić Maksimović, and Vuk Maksimović. "Phenolics and Sesquiterpene Lactones Profile of Red and Green Lettuce: Combined Effect of Cultivar, Microbiological Fertiliser, and Season." Plants 12, no. 14 (July 11, 2023): 2616. http://dx.doi.org/10.3390/plants12142616.

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The main goal of our study was to find an optimal combination of tested factors to achieve lettuce rich in bioactive compounds sustaining its pleasant taste. We examined three red and three green cultivars in a greenhouse using two microbiological fertilisers (EM Aktiv and Vital Tricho), and their combination. Plants were grown in three consecutive growing seasons (autumn, winter, and spring). Lactones accumulated in autumn, whereas phenolics’ concentration rose during winter. Red cultivars showed higher phenolics and lactone content, where chicoric acid and luteolin-7-glucoside were the most abundant in the ‘Gaugin’ winter trial. Lactucopicrin was the predominant lactone among tested cultivars with the highest value in the red cultivar ‘Carmesi’. Solely applicated, the fertiliser EM Aktiv and Vital Tricho led to significantly higher phenolic acid and dihydrolactucopicrin content, while combined, there were notably increased levels of all detected lactones. Application of single fertilisers had no effect on flavonoid content, while the combination even reduced it. A sensory analysis showed a negative correlation between overall taste and total sesquiterpene lactones, lactucopicrin, caffeoylmalic, and chlorogenic acid, indicating a less bitter taste with decreasing content of these compounds. Our findings indicate that the cultivar, fertiliser, and growing season jointly affected all of the tested parameters, highlighting the differences in the application of EM Aktiv, Vital Tricho, and their combination.
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Maksymiak, Magdalena, Tomasz Bałakier, Janusz Jurczak, Marek Kowalczuk, and Grazyna Adamus. "Bioactive (co)oligoesters with antioxidant properties – synthesis and structural characterization at the molecular level." RSC Advances 6, no. 62 (2016): 57751–61. http://dx.doi.org/10.1039/c6ra09870c.

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Erasto, P., D. S. Grierson, and A. J. Afolayan. "Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina." Journal of Ethnopharmacology 106, no. 1 (June 2006): 117–20. http://dx.doi.org/10.1016/j.jep.2005.12.016.

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Lu, X., G. Zhu, Z. Wang, S. Ma, J. Ji, and Z. Zhang. "Enyne cyclization methodology for the synthesis of bioactive lactones." Pure and Applied Chemistry 69, no. 3 (January 1, 1997): 553–58. http://dx.doi.org/10.1351/pac199769030553.

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Ren, Qiao, Shaofa Sun, Jiayao Huang, Wenjun Li, Minghu Wu, Haibing Guo, and Jian Wang. "An enantioselective cascade reaction between α,β-unsaturated aldehydes and malonic half-thioesters: a rapid access to chiral δ-lactones." Chem. Commun. 50, no. 46 (2014): 6137–40. http://dx.doi.org/10.1039/c4cc01736f.

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Chiral saturated δ-lactones, ubiquitous bioactive O-heterocycles in nature, are readily prepared via a direct enantioselective decarboxylation of α,β-unsaturated carbonyls and malonic half-thioesters.
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Dissertations / Theses on the topic "Bioactive Lactones"

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Filipa, P. da Cruz Ana. "C-branched carbohydrate lactones : Versatile intermediatesin the synthesis of branched bioactive." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509913.

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Parat, Sabrina. "Approche synthétique d’une delta-lactone alpha, beta-insaturée naturelle bioactive, la (–)-Callystatine A." Aix-Marseille 3, 2008. http://www.theses.fr/2008AIX30016.

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La (–)-Callystatine A est un produit naturel bioactif d’origine marine. Son activité biologique et sa structure complexe, qui font de cette molécule une cible synthétique de choix, ont suscité notre intérêt. Le mémoire débute par une partie bibliographique consacrée à l’examen des neuf synthèses totales de la Callystatine A, suivie de l’application de la désymétrisation énantiosélective des composés méso en synthèse totale. Notre stratégie repose sur la synthèse originale de trois fragments. La chaîne polypropionate du fragment Ouest est synthétisée via la désymétrisation d’un diol méso et une crotylation diastéréosélective. Une cycloaddition [2+2] suivie d’une translactonisation d’une β-lactone permettent de former le motif δ-lactone du fragment Est. Le fragment Central est obtenu sous sa forme racémique. Notre synthèse est ainsi validée par l’obtention de la structure carbonée de ces trois précurseurs. Un couplage palladocatalysé et une oléfination permettront d’obtenir la cible
(–)-Callystatin A is a bioactive marine natural product. Our interest in the total synthsis of Callystatin A was triggered by its inherent complexity and potent biological activities. This thesis starts with a bibliographic part devoted to the previously reported nine total syntheses of Callystatin A and an overview of the use of meso compounds desymmetrisation in total synthesis. Our convergent synthesis is based on the original synthesis of three main fragments. The Western one was obtained by an enantioselective desymmetrisation of a meso diol and a diastereoselective crotylation to form the polypropionate part. A [2+2] cycloaddition and a translactonization of a β-lactone led the δ-lactone unit of the Eastern moiety. The Central part was obtained in its racemic form. Our strategy was validated by the backbone synthesis precursors. A palladium-mediated coupling combined with an olefination reaction should afford the target
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Rabiller, Christine. "Nouvelles voies de synthèse de lactones bioactives." Nancy 1, 1994. http://www.theses.fr/1994NAN10339.

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La synthèse enantiospécifique de lactones bioactives, inhibitrices d'une part de l'hmgcoa réductase, et d'autre part des lipases pancréatiques a été entreprise. Dans une première partie, l'accès facile et rapide à des composés de structure didesoxy-2-4-hexopyranose, chiron clé pour la synthèse d'inhibiteurs de la biosynthèse du cholestérol, a été réalisé par transformation stéréospécifique du 1,6-anhydro-beta-d-glucopyranose obtenu par pyrolyse dans de bonnes conditions qui ont été mises au point dans ce travail. Dans la deuxième partie, l'application des méthodes de création de liaison carbone-carbone en c-2 et en c-6 sur un dérivé du glucose, a permis d'ouvrir deux nouvelles voies pour la préparation d'intermédiaires clés de la synthèse de la valilactone, le tetrahydrolipstatine et la tetrahydroexterastine, composes d'intérêt pharmacologique pour le traitement de l'obésité
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Vlad-Cristea, Mirela Simona. "Production of bioactive lactobionic acid using a novel catalytic method." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24772/24772.pdf.

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Thèse (M.Sc. )--Université Laval, 2007.
Texte en anglais avec des résumés en anglais et en français. Bibliogr.: f. 93-94. Publié aussi en version électronique dans la Collection Mémoires et thèses électroniques.
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Khay, Mom. "Molécules bioactives issues de la biodiversité cambodgienne : Vernonia cinerea Less. et Vernonia elliptica DC." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5500.

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Nos travaux de doctorat s’inscrivent dans la démarche de la valorisation de la biodiversité végétale cambodgienne. Les objectifs portaient sur les travaux phytochimique et pharmacologique de deux plantes cambodgiennes : Vernonia cinerea et Vernonia elliptica. Une méthode de dosage par CLHP du composé 8α-tigloyloxyhirsutinolide 13-O-acetate (H1) appartenant à la classe des lactones sesquiterpènes de V. cinerea a été mise au point et validée dans le but de déterminer la teneur de ce composé. La teneur en H1 varie entre 0,08 % à 0,17 % pour les échantillons étudiés provenant de 4 régions du Cambodge. L’évaluation de l’activité antiproliférative in vitro des extraits de V. cinerea, et du composé H1 a été réalisée vis-à-vis de deux lignées cellulaires cancéreuses humaines HT29 et HepG2. Le composé H1 présente une CI50 similaire à celle du contrôle positif 5FU, 4,3 ± 0,2 versus 5,4 ± 0,9 µM vis-à-vis de la lignée HepG2. Les résultats intéressants obtenus sur V. cinerea nous ont incités à travailler sur d’autres espèces du genre Vernonia qui poussent au Cambodge, Vernonia elliptica. L’étude phytochimique menée sur cette plante a permis d’isoler un lignane [(+)-Syringaresinol] et deux lactones sesquiterpènes [(+)-8,13-diacetyl-piptocarphol et Glaucolide B]. Ces composés sont décrits dans cette plante pour la première fois. L’étude in vitro de l’activité antiproliférative des extraits de V. elliptica montre que l’extrait dichlorométhane obtenu à partir de l’extrait aqueux est très actif
Our PhD work is in the process of valorization of the Cambodian plant biodiversity. The objectives focused on phytochemical and pharmacological studies of two Cambodian plants of the Vernonia genus: Vernonia cinerea and Vernonia elliptica.An analytical HPLC method was developed and validated to quantify the major compound 8α-tigloyloxyhirsutinolide 13-O-acetate (H1) of Vernonia cinerea. We found that the compound H1 content ranges from 0.08% to 0.17% in samples collected from cambodian regions. We thus evaluated the anti-proliferative activity in vitro of extracts of V. cinerea and H1 compound against two human cancer cell lines HT29 and HepG2. For HepG2 cell line, the compound H1 has a similar IC50 to the positive control 5FU, 4.3 ± 0.2 versus 5.4 ± 0.9 µM. The interesting results on V. cinerea encouraged us to study other species of Vernonia genus growing in Cambodia, Vernonia elliptica. The phytochemical study conducted on this plant led to isolate a lignan [(+)-syringaresinol] and two sesquiterpene lactones [(+)-8,13-diacetyl-piptocarphol and Glaucolide B]. These compounds were described in this plant for the first time. The in vitro study of the anti-proliferative activity of the extracts of V. elliptica shows that the dichloromethane extract obtained from aqueous extract is very active
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Rasamiravaka, Tsiry. "Inhibition du mécanisme de quorum sensing et de la formation de biofilm chez Pseudomonas aerugionsa par des composés bioactifs de Dalbergia trichocarpa (Fabaceae)." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209303.

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Depuis quelques décennies, les bactéries pathogènes multi-résistantes aux antibiotiques sont de plus en plus répandues dans le monde. Cette situation a suscité le besoin et l'intérêt de trouver des médicaments antibactériens avec de nouvelles cibles potentiels. La découverte des systèmes de communication de type quorum sensing (QS) régulant la virulence bactérienne représente une des cibles privilégiées pour contrôler les bactéries pathogènes autrement qu’en interférant avec leur croissance bactérienne. Dans l’écosystème naturel, un grand nombre d'organismes (Eucaryotes et Procaryotes) co-existent en synthétisant chacun de leur côté des métabolites secondaires. Les plantes, étant en permanence en contact avec des bactéries, synthétisent des métabolites secondaires capables d’inhiber l’expression des gènes de virulence chez les bactéries sans pour autant affecter ni leur croissance ni leur viabilité. Notre objectif a été de contribuer à la valorisation de la biodiversité malgache en identifiant des plantes et en y isolant les composés actifs présentant une capacité à perturber le mécanisme de QS chez P. aeruginosa PAO1, une bactérie pathogène opportuniste de l’homme, des animaux et des plantes. Dans ce but, nous avons tout d’abord réalisé un criblage d’activité anti-QS de différents flavonoïdes commerciaux. De ce criblage, la narigenine et la naringine ont été sélectionnées pour être les molécules de contrôle positif et négatif des tests d’activité anti-QS, respectivement. Par la suite, 4 espèces de Dalbergia endémique de Madagascar ont fait l’objet de criblage pour leur activité anti-QS. Ce travail a fait ressortir l’activité anti-QS très intéressante de l’écorce de D. trichocarpa à partir de laquelle nous avons isolée le composé actif nommé la coumarate de l’aldéhyde-oléanolique (OALC). Le contrôle naringénine et l’OALC ne présente aucun effets inhibiteurs sur la croissance bactérienne de P. aeruginosa PAO1 et sur l’expression du gène QS-indépendant aceA suggérant une activité d’inhibition spécifiquement liée au QS. Cependant, ces deux molécules présentent des spectres d’inhibition différente. En effet, les deux molécules diffèrent dans le sens que la naringenine n’inhibe pas l’expression du gène gacA et la motilité de type twitching contrairement à l’OALC. Ces résultats suggèrent que l’OALC et la naringénine représente des candidats potentiels pour des investigations in vivo quant à leur effet anti-QS et anti-biofilm sur des modèles infectieux d’organismes supérieurs. Par ailleurs, ils démontrent la richesse des plantes malgaches comme sources de nouvelles molécules anti-virulence ainsi que l’importance de telle investigation afin de renforcer notre arsenal thérapeutique en composé antibactérienne dans la lutte continuelle contre les bactéries pathogènes/Since few decades, multidrug resistant bacteria spread all over the world. This situation gives rise to the need and interest in finding antibacterial drugs with novel potent target. Discovery of communication system termed Quorum Sensing (QS) which regulate bacterial virulence factor represent privileged target in another way than interfering with bacterial growth. In natural ecosystem, many organisms (Eukaryotes and Prokaryotes) produce secondary metabolites. As plants are permanently in contact with bacteria, they have synthetized secondary metabolites which inhibit bacterial virulence gene expression without affecting bacterial viability. Our goal was to contribute to the valorization of Malagasy biodiversity and specifically to identify plants and isolate bioactive compound presenting ability to disrupt QS mechanism in P. aeruginosa, opportunistic pathogen bacteria in plants, animals and human. In this purpose, screening of commercial available flavonoids has been firstly carried out. From this screening, naringenin and naringin have been selected to be used as positive and negative QS inhibitor controls, respectively. Subsequently, Four Malagasy endemic Dalbergia species have been screened for their anti-QS activity. This work pointed out the interesting anti-QS activity of D. trichocarpa bark extract which led to the isolation of oleanolic aldehyde coumarate (OALC) as one major bioactive compound. At the concentration tested, naringenin and OALC did not affect P. aeruginosa PAO1 viability and didn’t reduce QS-independent aceA gene expression suggesting a specific anti-QS activity. However, these two compounds present different inhibition spectrum. Indeed, naringenin didn’t inhibit gacA gene expression and twitching motility contrarily to OALC. These results suggest that OALC and naringenin represent potent candidates for in vivo investigations in their anti-QS and anti-biofilm activity onto eukaryotes infectious model. Besides, this finding demonstrated the potent source for novel anti-virulence compounds of Malagasy flora and the importance of this kind of research to strengthen our antimicrobial therapeutic arsenal with the ongoing struggle against bacterial infection.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
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Ho, Ching-Jen, and 何景仁. "Studies on the Bioactive Diterpene Lactones of Soft Coral Cespitularia taeniata." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/53008000460280192972.

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碩士
國立中山大學
海洋生物科技暨資源學系研究所
94
Four new diterpenoids, cespitulactones A-B (1-2), C4B1 (7) and E3A (8), were isolated from the soft coral Cespitularia taeniata collected in Taiwan, at a depth of 25 m, together with five known compounds, cespitularin F (3), 6-O-acetylcespitularin F (4), cespitularin D (5), flaccidoxide-13-acetate (6) and florlide A (9). Compound 1 possesses a novel structure with a bond cleavage between C-10 and C-11, and having a 14-membered lactone ring junction between C-10 and C-12. Compounds 2 and 8 have the verticillane skeleton, and compound 9 possesses the cespitularane skeleton. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical derivatization. The isolated compounds were also evaluated for cytotoxicity toward human cancer cell lines. Compound 1 exhibited significant cytotoxicity against human cervical epitheloid carcinoma (HeLa) and colon adenocarcinoma (DLD-1) cancer cells with IC50 of 3.69 and 9.98 μg/mL, respectively. Flaccidoxide-13-acetate (6) showed mild activity against human medulloblastoma (Daoy) and colon (WiDr) cancer cells at 16.9 and 13.8 μg/mL, respectively.
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Jang, Jiun-yang, and 張俊揚. "Studies on Bioactive Sesquiterpene Lactones From Eupatorium hualienense, Ou, Chung & Peng." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/43852480410824303871.

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碩士
國立中山大學
海洋資源學系研究所
92
Sesquiterpene lactones contain α,β-unsaturated-γ-lactone as a major structural feature, which in recent studies have been shown to be associ- ated with anti-tumor, cytotoxic, anti-microbial and phytotoxic activities. Previous researchers isolated sesquiterpene lactones from Eupatorium formosanum Hay. Thus, we studied Eupatorium hualienense, a unique speces in Taiwan that grows near the eastern coast. Five new sesquiter- pene lactones of the germacranolide type, eupahualins A-E (1-5) along with the known lactone, eupasimplicin B (6). Their structures were determined by 1D-NMR(1H-NMR,13C-NMR) and 2D-NMR(COSY、NOESY、HMQC、HMBC). Eupahualin A (1) exhibits an aldehyde at C-10 and an a,b-unsatura ted acyl group at C-8. Eupahualin B (2) also has an aldehyde at C-10. The Z-form of C-4, C-5 double bond in eupahualin B (2) is the main difference from the trans-form C-4, C-5 double bond in eupahualin A (1). The difference of eupahualin C (3) and eupahualin A (1) lies in structure of a ester group at C-8. The methyl at C-4'''' in eupahualin A (1) was changed into hydroxy methyl while the hydroxy methyl of eupahualin A (1) was changed to methyl in eupahualin C (3). Eupahualin D (4) shows exocyclic double bond at C-10, OH at C-1 and OAc at C-3. An carboxylic group (COOH) at C-10 in eupahualin E (5) is the only difference from which in eupahualin A (1).
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Tseng, Pei-Yi, and 曾佩儀. "Studies on the Bioactive Constituents Hirsutinolide-type Sesquiterpene lactones and Flavonoids from Vernonia cinerea L." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/68227782831849338527.

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碩士
國立陽明大學
生命科學系暨基因體科學研究所
100
Vernonia cinerea Less. (Compositae) is an annual herb which is used medicinally for a variety of purposes, including reducing fever, and promoting digestion. Previous investigations have shown that crude extracts of V. cinerea possess analgesic, antipyretic, antimalarial, antimicrobial, and cytotoxic activities. By a series of chromatography and bioassay-directed fractionation, seventeen hirsutinolide-type sesquiterpene lactones containing six new compounds, vernolides-E~J (V1~V6), eleven known ones, 8α-(2-methylacryloyloxy)-1β,4β-epoxy-1α-methoxy-13-O-acetate- 10βH-germacra-5E,7(11)-dien-12,6-olide (V7), vernolide-B (V8) , hirsutinolide 13-O-acetate (V9), 8α-(2-methylacryloyloxy)-hirsutinolide-13-O- acetate (V10), 8α-tigloyloxyhirsutinolide-13-O-acetate (V11), vernolide-A (V12), 8β-(2-methylacryloloxy)-1-O-methyl-hirsutinolide (V13), 8α-(2-hydroxymethacryloyloxy)-hirsutinolide-13-O-acetate (V14), vernobockolide B (V15), vernolide-D (V16), and 8α-tiglogloxy-hirsutinolide (V17), together with six flavonoids, 6,7,8,4'-tetramethoxyflavone (V18), 5,6,7,4'-tetramethoxyflavone (V19), 6,7,8,3',4'-pentamethoxyflavone (V20), apigenin (V21) , luteolin-7-O-β-D-glucopyranoside (V22), and genkwanin (V23) were isolated from 95% EtOH extract of Taiwanese V. cinerea. Structural elucidation of these compounds were based on spectroscopic analyses (MS, UV, IR, and NMR techniques), as well as comparison with the reported data. Cytotoxic assay showed that compounds V3, V4, V7, V8, V11, and V16 possess cytotoxicity against four human tumor cell lines (HEp-2, WiDr, A549, Hep-G2, ED50: 17~39 μM). The inhibitory effects on nitric oxide (NO) produced by RAW264.7 macrophages in response to lipopolysaccharide (LPS) showed that V3, V4, V7, V8, and V11 (IC50: 0.2~1.9 μM) have potent anti-inflammatory activity. These results indicated that the bioactive isolates from V.cinerea could be served as lead compounds for the development of anti- inflammatory drug.
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Carvalho, Maria João Menezes. "Caracterização e isolamento de compostos bioactivos do fungo Laurobasidium lauri (Madre de louro)." Master's thesis, 2010. http://hdl.handle.net/10400.13/626.

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Os objectivos deste trabalho consistiram em desenvolver um método de separação eficaz e reprodutível de modo a isolar as lactonas sesquiterpénicas - dehidrocostus e costunolida - de extractos do fungo parasita da espécie Laurus novocanariensis - Laurobasidium lauri; em testar os compostos relativamente às suas capacidades antioxidantes e bioactivas - citotoxicidade e alelopatia - e em obter uma quantidade considerável destas lactonas de modo a enviar para laboratórios em parceria para realização de testes de actividade anticancerígena in vitro (Instituto Canário de Investigação em Cancro), de antituberculose in vivo (Instituto politécnico Nacional, México), de actividade anti-inflamatória in vivo (UNIVALI, Brasil) e de actividade anti-ulcerativa in vivo. Neste trabalho foi possível isolar 116 mg de lactona costunolida com 97% de pureza através do fraccionamento do extracto de Madre de Louro em hexano pela técnica de cromatografia em coluna aberta com sistema de eluentes Hexano:Acetato de etilo (50:0 – 43:7 mL), procedendo à sua identificação por HPLC-MS e RMN 13C, não tendo sido possível atingir o mesmo objectivo para a lactona dehidrocostus. O extracto de Madre de Louro em Metanol demonstrou ser a amostra com maior poder antioxidante relativamente aos teste de ABTS, DPPH e FRAP, enquanto o extracto em Diclorometano apresentou maior poder antioxidante no teste do β-caroteno/ácido linoléico. No que toca aos ensaios biológicos, o extracto de madre de louro em hexano foi o que apresentou um valor de DL50 mais baixo (0,1mg/mL) representando assim maior poder de toxicidade perante as larvas de camarão (Artemia salina).
Universidade da Madeira
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Books on the topic "Bioactive Lactones"

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Doran, Robert. Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1.

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Doran, Robert. Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones. Springer, 2015.

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Doran, Robert. Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones. Springer, 2016.

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Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of a Alpha-Aryl Ketones. Springer International Publishing AG, 2015.

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Book chapters on the topic "Bioactive Lactones"

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Ye, Xiang-Yang, and Pratik Devasthale. "Carboxylic Acids and Lactones as HMG-CoA Reductase Inhibitors." In Bioactive Carboxylic Compound Classes: Pharmaceuticals and Agrochemicals, 71–85. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527693931.ch6.

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Chaturvedi, Devdutt, Parmesh Kumar Dwivedi, and Mamta Mishra. "Sesquiterpene Lactones: A Versatile Class of Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Anticancer Agents." In Bioactive Natural Products, 321–48. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2015. http://dx.doi.org/10.1002/9783527684403.ch11.

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Doran, Robert. "Introduction to the Total Synthesis of Lactone-Containing Natural Products Using ZrCl4." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 1–11. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_1.

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Doran, Robert. "Asymmetric Synthesis of Both Enantiomers of a δ-Lactone Analogue of Muricatacin." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 35–56. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_3.

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Doran, Robert. "Asymmetric Synthesis of the β-Methyl-Substituted Analogues of (+)-Tanikolide and (–)-Malyngolide." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 13–34. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_2.

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Doran, Robert. "Introduction to the Development of a Catalytic Asymmetric Synthesis of Tertiary α-Aryl Ketones." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 57–102. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_4.

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Doran, Robert. "A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 103–25. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_5.

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Doran, Robert. "Asymmetric Synthesis of Tertiary α-Aryl Ketones by Decarboxylative Asymmetric Protonation." In Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones, 127–75. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20544-1_6.

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Sülsen, Valeria P., Orlando G. Elso, Jimena Borgo, Laura C. Laurella, and Cesar A. N. Catalán. "Recent patents on sesquiterpene lactones with therapeutic application." In Bioactive Natural Products, 129–94. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-819487-4.00017-3.

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Rajak, Naina, Kavita, Praveen Kumar, Shikha Singh, and Neha Garg. "Pharmacological, Therapeutic, and Immunomodulatory Role of Tinospora cordifolia." In Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach, 89–104. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123289123010010.

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Tinospora cordifolia (TC, Giloy, Guduchi, or Amrita) is a valuable medicinal herb in the Indian System of Medicine (ISM), Chinese, and other traditional systems of medicine. TC contains a broad array of therapeutic phytoconstituents like alkaloids, glycosides, steroids, terpenoids, aliphatic compounds, diterpene lactones, phenolics, and flavonoids. TC is hailed for its therapeutic use with anti-inflammatory, anti-cancer, anti-diabetic, cardiac disease, anti-arthritis, and anti-microbial properties. TC induces immunomodulatory effects through the induction of macrophage activation, pro-inflammatory and anti-inflammatory cytokines, lymphocyte proliferation, and also secretion of interleukins. The present chapter highlights the biological properties, therapeutic use, and immunomodulatory pathways of Tinospora cordifolia.
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Conference papers on the topic "Bioactive Lactones"

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Oliveira, Wanderley Pereira, Victor Oloruntoba Bankole, and Claudia Regina F. Souza. "Spray dried proliposomes of Rosmarinus officinalis polyphenols: a quality by design approach." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7859.

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Harnessing the benefits of rosemary polyphenols is limited by variability in their physicochemical properties. These limitations may be overcome by encapsulation in systems possessing hydro-lipophilic centers thereby accommodating molecules of different polarities. Proliposomes offer a viable option in this regards, being particles which form liposomal suspension in water. Lyophilized extracts of rosemary was encapsulated in hydrogenatedsoyphosphatidylcholine/cholesterol by solvent replacement method. Spray dried proliposomes were obtained with lactose as carrier. Using Central Composite Design, the effects of lipid, extract and carrier concentrations on response variables including bioactive content and retention, moisture content characteristics, recuperation and redispersibility were evaluated by statistical analysis. Keywords: Polyphenols; antioxidant; proliposomes; spray drying
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