Journal articles: 'Bioactive Indole Alkaloids'

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Khan, Neyaz A., Navdeep Kaur, Peter Owens, Olivier P. Thomas, and Aoife Boyd. "Bis-Indole Alkaloids Isolated from the Sponge Spongosorites calcicola Disrupt Cell Membranes of MRSA." International Journal of Molecular Sciences 23, no. 4 (February 11, 2022): 1991. http://dx.doi.org/10.3390/ijms23041991.

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Antimicrobial resistance (AMR) is a global health challenge with methicillin resistant Staphylococcus aureus (MRSA), a leading cause of nosocomial infection. In the search for novel antibiotics, marine sponges have become model organisms as they produce diverse bioactive compounds. We investigated and compared the antibacterial potential of 3 bis-indole alkaloids—bromodeoxytopsentin, bromotopsentin and spongotine A—isolated from the Northeastern Atlantic sponge Spongosorites calcicola. Antimicrobial activity was determined by MIC and time-kill assays. The mechanism of action of bis-indoles was assessed using bacterial cytological profiling via fluorescence microscopy. Finally, we investigated the ability of bis-indole alkaloids to decrease the cytotoxicity of pathogens upon co-incubation with HeLa cells through the measurement of mammalian cell lysis. The bis-indoles were bactericidal to clinically relevant Gram-positive pathogens including MRSA and to the Gram-negative gastroenteric pathogen Vibrio parahaemolyticus. Furthermore, the alkaloids were synergistic in combination with conventional antibiotics. Antimicrobial activity of the bis-indole alkaloids was due to rapid disruption and permeabilization of the bacterial cell membrane. Significantly, the bis-indoles reduced pathogen cytotoxicity toward mammalian cells, indicating their ability to prevent bacterial virulence. In conclusion, sponge bis-indole alkaloids are membrane-permeabilizing agents that represent good antibiotic candidates because of their potency against Gram-positive and Gram-negative bacterial pathogens.

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Kirsch, Gilbert, Eslam El-Sawy, and Ahmed Abdelwahab. "Utilization of 1H-Indole-3-carboxaldehyde as a Precursor for the Synthesis of Bioactive Indole Alkaloids." Synthesis 50, no. 23 (October 15, 2018): 4525–38. http://dx.doi.org/10.1055/s-0037-1610288.

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Indole alkaloids constitute a large class of natural products and their diverse and complex structures have been attributed to potent biological activities such as anticancer, anti-inflammatory, antimicrobial, antimalarial, antiplasmodial and protein kinase inhibition. The isolation of bioactive compounds from natural sources is difficult, costly and an extremely time-consuming process, therefore synthetic pathways are more convenient than natural separation to deliver such compounds in considerable amounts. In this respect, this review provides comprehensive information on the structures and the synthesis of bioactive indole alkaloids utilizing 1H-indole-3-carboxaldehyde and its derivatives as starting compounds. 1 Overview2 Phytoalexins2.1 Brassinin, Cyclobrassinin and Brassitin2.2 1-Methoxybrassinin, 1-Methoxyspirobrassinol and 1-Methoxyspirobrassinin2.3 4-Methoxybrassinin and 4-Methoxycyclobrassinin2.4 Cyclobrassinone2.5 Brassilexin2.6 (S)-(–)-Spirobrassinin2.7 Camalexin3 Bis(indole) Alkaloids: Rhopaladines A–D4 Coscinamides A and B5 α-Cyclopiazonic Acid6 Dipodazine7 Isocryptolepine8 Apparicine9 Carbazole Alkaloids: Mukonine and Clausine E10 Indolmycin11 Conclusion

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Pan, Li, César Terrazas, Ulyana Muñoz Acuña, Tran Ngoc Ninh, Heebyung Chai, Esperanza J. Carcache de Blanco, Djaja D. Soejarto, Abhay R. Satoskar, and A. Douglas Kinghorn. "Bioactive indole alkaloids isolated from Alstonia angustifolia." Phytochemistry Letters 10 (December 2014): liv—lix. http://dx.doi.org/10.1016/j.phytol.2014.06.010.

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Klein-Júnior, Luiz C., Sylvian Cretton, Yvan Vander Heyden, André L. Gasper, Samad Nejad-Ebrahimi, Philippe Christen, and Amélia T. Henriques. "Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa." Journal of Natural Products 83, no. 4 (March 9, 2020): 852–63. http://dx.doi.org/10.1021/acs.jnatprod.9b00469.

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Liu, Yan-Ping, Qing-Long Liu, Xiang-Lin Zhang, Hai-Yuan Niu, Chun-Yan Guan, Fu-Kang Sun, Wei Xu, and Yan-Hui Fu. "Bioactive monoterpene indole alkaloids from Nauclea officinalis." Bioorganic Chemistry 83 (March 2019): 1–5. http://dx.doi.org/10.1016/j.bioorg.2018.10.013.

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Zhang, Yanyan, Ting Han, Qianliang Ming, Lingshang Wu, Khalid Rahman, and Luping Qin. "Alkaloids Produced by Endophytic Fungi: A Review." Natural Product Communications 7, no. 7 (July 2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700742.

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In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for producing bioactive alkaloids such as quinoline and isoquinoline, amines and amides, indole derivatives, pyridines, and quinazolines. The biological activities and action mechanisms of these alkaloids from endophytic fungi are also introduced. Furthermore, the relationships between alkaloid-producing endophytes and their host plants, as well as their potential applications in the future are discussed.

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Bozkurt, Buket, Gulen I. Kaya, and Nehir U. Somer. "Chemical Composition and Enzyme Inhibitory Activities of Turkish Pancratium maritimum Bulbs." Natural Product Communications 14, no. 10 (October 2019): 1934578X1987290. http://dx.doi.org/10.1177/1934578x19872905.

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The chemical composition of the bulbs of Pancratium maritimum L. (Amaryllidaceae) from Turkey (Pamucak, Aydın) has been determined by gas chromatography-mass spectrometry. A total of 29 compounds belonging to different skeletal types of Amaryllidaceae alkaloids were identified. Lycorine, galanthamine, crinine, and pancracine were found as major constituents. Interestingly, indole alkaloids (1-acetyl-β -carboline and galanthindole) were also detected. Acetylcholinesterase, butyrylcholinesterase, and prolyl oligopeptidase inhibitory activity potentials of the alkaloidal extract were also determined. The results of the present study show that Turkish P. maritimum comprises a rich repository for bioactive alkaloids with intriguing structural diversities.

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Lee, Kit, Bing-Nan Zhou, David Kingston, Abraham Vaisberg, and Gerald Hammond. "Bioactive Indole Alkaloids from the Bark ofUncaria guianensis." Planta Medica 65, no. 08 (December 1999): 759–60. http://dx.doi.org/10.1055/s-2006-960860.

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Rahman, M. Toufiqur, Jeffrey R. Deschamps, Gregory H. Imler, and James M. Cook. "Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids." Chemistry - A European Journal 24, no. 10 (January 23, 2018): 2354–59. http://dx.doi.org/10.1002/chem.201705575.

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Athipornchai, Anan. "A Review on Tabernaemontana spp.: Multipotential Medicinal Plant." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (May 1, 2018): 45. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.11478.

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Tabernaemontana is one of the genera that is used in Chinese, Ayurvedic and Thai traditional medicine for the treatment several diseases. From a chemical point of view, the great majority of Tabernaemontana species have already been subjected to isolation and identification of indole alkaloids present in their several parts. Many of indole alkaloids have been shown to exhibit a wide array of biological activities. The biogenesis, classification and biological activities of the indole alkaloids found in Tabernaemontana species were discussed in this review and its brings the research up-to-date on the bioactive compounds produced by Tabernaemontana species, directly or indirectly related to human health.

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Sevik Kilicaslan, Ozlem, Sylvian Cretton, Luis Quirós-Guerrero, Merveilles A. Bella, Marcel Kaiser, Pascal Mäser, Joseph T. Ndongo, and Muriel Cuendet. "Isolation and Structural Elucidation of Compounds from Pleiocarpa bicarpellata and Their In Vitro Antiprotozoal Activity." Molecules 27, no. 7 (March 28, 2022): 2200. http://dx.doi.org/10.3390/molecules27072200.

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Species of the genus Pleiocarpa are used in traditional medicine against fever and malaria. The present study focuses on the isolation and identification of bioactive compounds from P. bicarpellata extracts, and the evaluation of their antiprotozoal activity. Fractionation and isolation combined to LC-HRMS/MS-based dereplication provided 16 compounds: seven indole alkaloids, four indoline alkaloids, two secoiridoid glycosides, two iridoid glycosides, and one phenolic glucoside. One of the quaternary indole alkaloids (7) and one indoline alkaloid (15) have never been reported before. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR experiments, UV, IR, and HRESIMS data. The absolute configurations were determined by comparison of the experimental and calculated ECD data. The extracts and isolated compounds were evaluated for their antiprotozoal activity towards Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum, as well as for their cytotoxicity against rat skeletal myoblast L6 cells. The dichloromethane/methanol (1:1) root extract showed strong activity against P. falciparum (IC50 value of 3.5 µg/mL). Among the compounds isolated, tubotaiwine (13) displayed the most significant antiplasmodial activity with an IC50 value of 8.5 µM and a selectivity index of 23.4. Therefore, P. bicarpallata extract can be considered as a source of indole alkaloids with antiplasmodial activity.

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Park, Jae Sung, Eunji Cho, Ji-Yeon Hwang, Sung Chul Park, Beomkoo Chung, Oh-Seok Kwon, Chung J. Sim, Dong-Chan Oh, Ki-Bong Oh, and Jongheon Shin. "Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge." Marine Drugs 19, no. 1 (December 23, 2020): 3. http://dx.doi.org/10.3390/md19010003.

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Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.

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Oliveros-Díaz, Andrés, Jesús Olivero-Verbel, Yina Pájaro-González, and Fredyc Díaz-Castillo. "Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq." Molecules 26, no. 12 (June 21, 2021): 3765. http://dx.doi.org/10.3390/molecules26123765.

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Alkaloids are a group of secondary metabolites that have been widely studied for the discovery of new drugs due to their properties on the central nervous system and their anti-inflammatory, antioxidant and anti-cancer activities. Molecular docking was performed for 10 indole alkaloids identified in the ethanol extract of Tabernaemontana cymosa Jacq. with 951 human targets involved in different diseases. The results were analyzed through the KEGG and STRING databases, finding the most relevant physiological associations for alkaloids. The molecule 5-oxocoronaridine proved to be the most active molecule against human proteins (binding energy affinity average = −9.2 kcal/mol) and the analysis of the interactions between the affected proteins pointed to the PI3K/ Akt/mTOR signaling pathway as the main target. The above indicates that indole alkaloids from T. cymosa constitute a promising source for the search and development of new treatments against different types of cancer.

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Srivastava, Mukul, Shikha Kesharwani, Roohi Kesharwani, Dilip K. Patel, and S. N. Singh. "A REVIEW ON POTENTIAL BIOACTIVE CHEMICAL FROM RAUWOLFIA SERPENTINA: RESERPINE." International Journal of Research in Ayurveda and Pharmacy 12, no. 1 (March 2, 2021): 106–9. http://dx.doi.org/10.7897/2277-4343.120123.

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The drug Rauwolfia serpentina is known to Indian system of medicine since last many centuries. Because of snake like shape of drug, it has been known as sarpgandha. Although Rauwolfia serpentina contain more than 50 alkaloids but Reserpine is the principal alkaloid of Rauwolfia serpentina. Reserpine has a success application in antihypertensive even at a smaller dose. Rhizomes of Rauwolfia serpentine also have hepatoprotective activity including antihypertensive, hepatoprotective, Rauwolfia serpentina have many other medicinal uses like: Antidiahoerreal, antipsychotic, sedative, anticancer (in breast) etc. Although Rauwolfia serpentina contains major four Indole alkaloids but main object of this context is to provide knowledge about the main active alkaloid Reserpine, having more concentration in the root of plant, play a major role in antihypertensive activity of Rauwolfia serpentina. A much lesser dose of Reserpine is required to provide an antihypertensive effect otherwise it can cause some serious adverse effect like- lethargy, sedation, psychiatric depression, hypotension, nausea, bradycardia, bronchospasm and withdrawal psychosis. Because of its potent activity Reserpine is still used as antihypertensive and sedative agent.

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Ramkissoon, Antonio, Mohindra Seepersaud, Anderson Maxwell, Jayaraj Jayaraman, and Adesh Ramsubhag. "Isolation and Antibacterial Activity of Indole Alkaloids from Pseudomonas aeruginosa UWI-1." Molecules 25, no. 16 (August 17, 2020): 3744. http://dx.doi.org/10.3390/molecules25163744.

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In this study, we report the first isolation of three antibiotic indole alkaloid compounds from a Pseudomonad bacterium, Pseudomonas aeruginosa UWI-1. The bacterium was batch fermented in a modified Luria Broth medium and compounds were solvent extracted and isolated by bioassay-guided fractionation. The three compounds were identified as (1) tris(1H-indol-3-yl) methylium, (2) bis(indol-3-yl) phenylmethane, and (3) indolo (2, 1b) quinazoline-6, 12 dione. A combination of 1D and 2D NMR, high-resolution mass spectrometry data and comparison from related data from the literature was used to determine the chemical structures of the compounds. Compounds 1–3 were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms using the broth microdilution technique. Compounds 1 and 2 displayed antibacterial activity against only Gram-positive pathogens, although 1 had significantly lower minimum inhibitory concentration (MIC) values than 2. Compound 3 displayed potent broad-spectrum antimicrobial activity against a range of Gram positive and negative bacteria. Several genes identified from the genome of P. aeruginosa UWI-1 were postulated to contribute to the biosynthesis of these compounds and we attempted to outline a possible route for bacterial synthesis. This study demonstrated the extended metabolic capability of Pseudomonas aeruginosa in synthesizing new chemotypes of bioactive compounds.

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Noldin, Vânia Floriani, Domingos Tabajara de Oliveira Martins, César Marcos Marcello, Joaquim Corsino da Silva Lima, Franco Delle Monache, and Valdir Cechinel Filho. "Phytochemical and Antiulcerogenic Properties of Rhizomes from Simaba ferruginea St. Hill. (Simaroubaceae)." Zeitschrift für Naturforschung C 60, no. 9-10 (October 1, 2005): 701–6. http://dx.doi.org/10.1515/znc-2005-9-1007.

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Abstract Simaba ferruginea (Simaroubaceae) is a Brazilian medicinal plant used in traditional medicine to treat several ailments, including gastric ulcers, fever, diarrhea, and dolorous and inflammatory processes. This study examines the chemical composition and antiulcerogenic effects of rhizomes from this plant. Bioassay-guided fractionation led to the isolation of two bioactive indole alkaloids called canthin-6-one (1) and 4-methoxycanthin-6-one (2). The alkaloid fraction and both alkaloids demonstrated potent antiulcerogenic effects when evaluated in gastric lesion-induced animals, as well as significant antinociceptive activity in mice. These results confirm and justify the popular use of S. ferruginea against gastric ulcers and dolorous processes.

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Wang, Zhijie, Yu Jiang, Xiujuan Xin, and Faliang An. "Bioactive indole alkaloids from insect derived endophytic Aspergillus lentulus." Fitoterapia 153 (September 2021): 104973. http://dx.doi.org/10.1016/j.fitote.2021.104973.

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Ohashi, Leticia Hiromi, Douglas Costa Gontijo, Maria Fernanda Alves do Nascimento, Luciano Ferreira Margalho, Geraldo Célio Brandão, and Alaíde Braga de Oliveira. "Extraction and Fractionation Effects on Antiplasmodial Activity and Phytochemical Composition of Palicourea hoffmannseggiana." Planta Medica International Open 8, no. 01 (April 2021): e34-e42. http://dx.doi.org/10.1055/a-1375-6456.

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AbstractThe present study on Palicourea hoffmannseggiana, which was collected at Marapanim, state of Pará, Brazil, comprises the preparation of different stem and leaf extracts and fractions. Ethanol, hydroethanol, and water extracts were prepared by several methods and evaluated for in vitro activity against resistant Plasmodium falciparum (W2 strain), disclosing a low parasite growth inhibition effect (< 50%). Dereplication by UPLC-DAD-ESI−MS of the leaf ethanol extract showed the presence of two known alkaloids, lyalosidic and strictosidinic acids, along with a sinapoyl ester of lyalosidic acid, with m/z 719.33 [M+H]+, which is possibly a new monoterpene indole alkaloid representative. Sequential liquid-liquid acid-base alkaloid separations from the leaf ethanol extract as well as directly from leaf powder afforded fractions of increased parasite growth inhibition, reaching up to 92.5±0.7%. The most bioactive fractions were shown to contain the β-carboline alkaloids harmane and 4-methyl-β-carboline, along with N-methyl-tryptamine and N-acetyl-tryptamine, while monoterpene indole alkaloids were detected in inactive fractions of these processes. The present results demonstrate that these preliminary fractionation methods can lead to significantly active fractions supporting an adequate scale-up to carrying out the isolation of anti-plasmodial compounds.

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Munir, Samman, Aqsa Shahid, Bilal Aslam, Usman Ali Ashfaq, Muhammad Sajid Hamid Akash, Muhammad Akhtar Ali, Ahmad Almatroudi, Khaled S. Allemailem, Muhammad Shahid Riaz Rajoka, and Mohsin Khurshid. "The Therapeutic Prospects of Naturally Occurring and Synthetic Indole Alkaloids for Depression and Anxiety Disorders." Evidence-Based Complementary and Alternative Medicine 2020 (October 16, 2020): 1–11. http://dx.doi.org/10.1155/2020/8836983.

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Depression and anxiety are the most common disorders among all age groups. Several antidepressant drugs including benzodiazepine, antidepressant tricyclics, azapirone, noradrenaline reuptake inhibitors, serotonin selective reuptake inhibitors, serotonin, noradrenaline reuptake inhibitors, and monoamine oxidase inhibitors have been used to treat these psychiatric disorders. However, these antidepressants are generally synthetic agents and can cause a wide range of side effects. The potential efficacy of plant-derived alkaloids has been reviewed against various neurodegenerative diseases including Alzheimer’s disease, Huntington disease, Parkinson’s disease, schizophrenia, and epilepsy. However, data correlating the indole alkaloids and antidepressant activity are limited. Natural products, especially plants and the marine environment, are rich sources of potential new drugs. Plants possess a variety of indole alkaloids, and compounds that have an indole moiety are related to serotonin, which is a neurotransmitter that regulates brain function and cognition, which in turn alleviates anxiety, and ensures a good mood and happiness. The present review is a summary of the bioactive compounds from plants and marine sources that contain the indole moiety, which can serve as potent antidepressants. The prospects of naturally occurring as well as synthetic indole alkaloids for the amelioration of anxiety and depression-related disorders, structure-activity relationship, and their therapeutic prospects have been discussed.

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Argade, Narshinha, and Pravat Mondal. "Formal Synthesis of Bioactive Indole Alkaloids Eburnamonine, Eburnaminol, and Vindeburnol." Synthesis 49, no. 08 (January 13, 2017): 1849–56. http://dx.doi.org/10.1055/s-0036-1588386.

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Lin, Li Ping, and Ren Xiang Tan. "Bioactive Alkaloids from Indole-3-carbinol Exposed Culture of Daldiniaeschscholzii." Chinese Journal of Chemistry 36, no. 8 (June 13, 2018): 749–53. http://dx.doi.org/10.1002/cjoc.201800160.

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22

Hadi, Surya. "MATARANINE A AND B: A NEW DIASTOMERIC INDOLE ALKALOID FROM Alstonia scholaris R.Br. OF LOMBOK ISLAND." Indonesian Journal of Chemistry 9, no. 3 (June 24, 2010): 466–69. http://dx.doi.org/10.22146/ijc.21517.

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Alstonia scholaris R. Br., (Apocynaceae) is widely distributed in Indonesia and in Lombok Island, the plant locally known as ";lolon nita"; has been used to treat malaria. To locate potential bioactive compounds, acid-base extraction was carried out. From the base fraction, two new indole alkaloids with diastomeric structure, named Mataranine A and B, were isolated. The structures of the two alkaloids were elucidated on the basis of UV, NMR and mass spectral data. Keywords: alkaloids, Alstonia scholaris, Lombok, mataranine

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Plazas, Erika, and Nicoletta Faraone. "Indole Alkaloids from Psychoactive Mushrooms: Chemical and Pharmacological Potential as Psychotherapeutic Agents." Biomedicines 11, no. 2 (February 5, 2023): 461. http://dx.doi.org/10.3390/biomedicines11020461.

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Neuropsychiatric diseases such as depression, anxiety, and post-traumatic stress represent a substantial long-term challenge for the global health systems because of their rising prevalence, uncertain neuropathology, and lack of effective pharmacological treatments. The approved existing studies constitute a piece of strong evidence whereby psychiatric drugs have shown to have unpleasant side effects and reduction of sustained tolerability, impacting patients’ quality of life. Thus, the implementation of innovative strategies and alternative sources of bioactive molecules for the search for neuropsychiatric agents are required to guarantee the success of more effective drug candidates. Psychotherapeutic use of indole alkaloids derived from magic mushrooms has shown great interest and potential as an alternative to the synthetic drugs currently used on the market. The focus on indole alkaloids is linked to their rich history, their use as pharmaceuticals, and their broad range of biological properties, collectively underscoring the indole heterocycle as significant in drug discovery. In this review, we aim to report the physicochemical and pharmacological characteristics of indole alkaloids, particularly those derived from magic mushrooms, highlighting the promising application of such active ingredients as safe and effective therapeutic agents for the treatment of neuropsychiatric disorders.

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Matsuura, Hélio Nitta, Mariana Ritter Rau, and Arthur Germano Fett-Neto. "Oxidative stress and production of bioactive monoterpene indole alkaloids: biotechnological implications." Biotechnology Letters 36, no. 2 (September 24, 2013): 191–200. http://dx.doi.org/10.1007/s10529-013-1348-6.

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Huang, Yuxiang, Hexin Tan, Zhiying Guo, Xunxun Wu, Qinglei Zhang, Lei Zhang, and Yong Diao. "The biosynthesis and genetic engineering of bioactive indole alkaloids in plants." Journal of Plant Biology 59, no. 3 (June 2016): 203–14. http://dx.doi.org/10.1007/s12374-016-0032-5.

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Muhaimin, Muhaimin, Muhammad Irhash Shalihin, and Madyawati Latief. "Anti-Inflammatory Activity of an Indole Alkaloid Isolated from Bebuas (Premna serratifolia)." Journal of Pure and Applied Chemistry Research 10, no. 2 (August 31, 2021): 84–103. http://dx.doi.org/10.21776/ub.jpacr.2021.010.02.584.

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Premna serratifolia known as bebuas has long been used by Malay comunity for both food and traditional medicine. The most notable advantage of this plant is to heal woman after childbirth and to raise the notion that contains anti-inflammatory bioactive compounds. In this study, the hexane extract of bebuas was only contained steroids. Meanwhile the ethanol extract contained various secondary metabolites such as phenolics, alkaloids, flavonoids, steroids and saponins. The ethanol extract was further separated since the targeted compound isolate was an alkaloid. The isolate obtained was a yellow crystal which transformed to yellow oil after being exposed to air. The anti-inflammatory evaluation of the compound gave a result with a strong activity with ED50 = 4.06 mg/KgBW. Characterization by UV-Vis and FT-IR showed that the isolate’s spectra pattern had similarities with bufotenine. It revealed that the isolate shared the same basic skeleton with the bufotenine, especially the indole skeleton. Furthermore, it also shared the same physical form with bufotenine. These evidences strengthened the assumption that the isolate was an indole alkaloid.

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Su, Chun-Han, Yu-Chieh Cheng, Yu-Chia Chang, Ting-Hsuan Kung, Yu-Li Chen, Kuei-Hung Lai, Hsi-Lung Hsieh, Chun-Yu Chen, Tsong-Long Hwang, and Yu-Liang Yang. "Untargeted LC-MS/MS-Based Multi-Informative Molecular Networking for Targeting the Antiproliferative Ingredients in Tetradium ruticarpum Fruit." Molecules 27, no. 14 (July 12, 2022): 4462. http://dx.doi.org/10.3390/molecules27144462.

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The fruit of Tetradium ruticarpum (TR) is commonly used in Chinese herbal medicine and it has known antiproliferative and antitumor activities, which can serve as a good source of functional ingredients. Although some antiproliferative compounds are reported to be present in TR fruit, most studies only focused on a limited range of metabolites. Therefore, in this study, the antiproliferative activity of different extracts of TR fruit was examined, and the potentially antiproliferative compounds were highlighted by applying an untargeted liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based multi-informative molecular networking strategy. The results showed that among different extracts of TR fruit, the EtOAc fraction F2-3 possessed the most potent antiproliferative activity against HL-60, T24, and LX-2 human cell lines. Through computational tool-aided structure prediction and integrating various data (sample taxonomy, antiproliferative activity, and compound identity) into a molecular network, a total of 11 indole alkaloids and 47 types of quinolone alkaloids were successfully annotated and visualized into three targeted bioactive molecular families. Within these families, up to 25 types of quinolone alkaloids were found that were previously unreported in TR fruit. Four indole alkaloids and five types of quinolone alkaloids were targeted as potentially antiproliferative compounds in the EtOAc fraction F2-3, and three (evodiamine, dehydroevodiamine, and schinifoline) of these targeted alkaloids can serve as marker compounds of F2-3. Evodiamine was verified to be one of the major antiproliferative compounds, and its structural analogues discovered in the molecular network were found to be promising antitumor agents. These results exemplify the application of an LC-MS/MS-based multi-informative molecular networking strategy in the discovery and annotation of bioactive compounds from complex mixtures of potential functional food ingredients.

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Yang, Jin, Lizhi Gong, Miaomiao Guo, Yu Jiang, Yi Ding, Zhijie Wang, Xiujuan Xin, and Faliang An. "Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021." Marine Drugs 19, no. 3 (March 17, 2021): 157. http://dx.doi.org/10.3390/md19030157.

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Six new prenylated indole diketopiperazine alkaloids, asperthrins A–F (1–6), along with eight known analogues (7–14), were isolated from the marine-derived endophytic fungus Aspergillus sp. YJ191021. Their planar structures and absolute configurations were elucidated by HR-ESI-MS, 1D/2D NMR data, and time-dependent density functional theory (TDDFT)/ECD calculation. The isolated compounds were assayed for their inhibition against three agricultural pathogenic fungi, four fish pathogenic bacteria, and two agricultural pathogenic bacteria. Compound 1 exhibited moderate antifungal and antibacterial activities against Vibrioanguillarum, Xanthomonas oryzae pv. Oryzicola, and Rhizoctoniasolani with minimal inhibitory concentration (MIC) values of 8, 12.5, and 25 μg/mL, respectively. Furthermore, 1 displayed notable anti-inflammatory activity with IC50 value of 1.46 ± 0.21 μM in Propionibacteriumacnes induced human monocyte cell line (THP-1).

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Berner, Mathias, Arto Tolvanen, and Reija Jokela. "ChemInform Abstract: Acid-Catalyzed Epimerization of Bioactive Indole Alkaloids and Their Derivatives." ChemInform 33, no. 36 (May 20, 2010): no. http://dx.doi.org/10.1002/chin.200236271.

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Chear, Nelson Jeng-Yeou, Tan Ai Fein Ching-Ga, Kooi-Yeong Khaw, Francisco León, Wen-Nee Tan, Siti R. Yusof, Christopher R. McCurdy, Vikneswaran Murugaiyah, and Surash Ramanathan. "Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies." Metabolites 13, no. 3 (March 7, 2023): 390. http://dx.doi.org/10.3390/metabo13030390.

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The Uncaria genus is notable for its therapeutic potential in treating age-related dementia, such as Alzheimer’s disease. A phytochemical study of the leaves of Malaysian Uncaria attenuata Korth., afforded an undescribed natural corynanthe-type oxindole alkaloid, isovillocarine D (1) together with two known indole alkaloids, villocarine A (2) and geissoschizine methyl ether (3), and their structural identification was performed with extensive mono- and bidimensional NMR and MS spectroscopic methods. The isolated alkaloids were evaluated for their acetylcholinesterase (AChE)- and butyrylcholinesterase (BChE)-inhibitory activity. The results indicated that compound (2) was the most potent inhibitor against both AChE and BChE, with IC50 values of 14.45 and 13.95 µM, respectively, whereas compounds (1) and (3) were selective BChE inhibitors with IC50 values of 35.28 and 17.65 µM, respectively. In addition, molecular docking studies revealed that compound (2) interacts with the five main regions of AChE via both hydrogen and hydrophobic bonding. In contrast to AChE, the interactions of (2) with the enzymatic site of BChE are established only through hydrophobic bonding. The current finding suggests that U. attenuata could be a good source of bioactive alkaloids for treating age-related dementia.

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Serdyuk, Olga, Igor Trushkov, Maxim Uchuskin, and Vladimir Abaev. "Indolylvinyl Ketones: Building Blocks for the Synthesis of Natural Products and Bioactive Compounds." Synthesis 51, no. 04 (January 24, 2019): 787–815. http://dx.doi.org/10.1055/s-0037-1611702.

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Indolylvinyl ketones are valuable building blocks that can be utilized for the synthesis of numerous natural products and bioactive molecules containing an indole core motif. Herein, we describe their application for the total synthesis of some alkaloids, their analogues, and a variety of other important compounds, with an emphasis on biologically active examples.1 Introduction2 Functionalization of the Enone C=C Bond2.1 Reduction2.2 Michael Addition2.3 Cycloaddition3 Transformation of the Carbonyl Group3.1 Reduction3.2 Knoevenagel Reaction3.3 Addition of Organometallic Compounds3.4 Olefination4 Reactions Involving the Enone Conjugate System С=С–С=О4.1 Reactions with 1,2-Dinucleophiles4.2 Reactions with Compounds Bearing an Active Methylene Group4.3 Reactions with 1,3-Dinucleophiles4.4 Reactions with 1,4-Dinucleophiles5 Functionalization of the Enone Methylene Group C(O)–CH2R5.1 Acylation/Crotonic Condensation and Related Transformations5.2 Enolization6 Functionalization of the Indole Core6.1 [4+2] Cycloaddition6.2 [3+3] Annulation6.3 Electrocyclic Reactions7 Miscellaneous8 Conclusions

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Scheidt, Karl A., and Eric R. Miller. "Enantioselective Syntheses of Yohimbine Alkaloids: Proving Grounds for New Catalytic Transformations." Synthesis 54, no. 05 (November 2, 2021): 1217–30. http://dx.doi.org/10.1055/a-1684-2942.

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AbstractThe total synthesis of bioactive alkaloids is an enduring challenge and an indication of the state of the art of chemical synthesis. With the explosion of catalytic asymmetric methods over the past three decades, these compelling targets have been fertile proving grounds for enantioselective bond forming transformations. These activities are summarized herein both to highlight the power and versatility of these methods and to instill future inspiration for new syntheses of these privileged natural products.1 Introduction2 Monoterpenoid Indole Alkaloids2.1 Corynanthe-Type MIAs3 Biosynthesis4 Biological Activity5 Scope6 Strategies in Yohimbine Alkaloid Synthesis6.1 Momose’s Formal Synthesis of (+)-Yohimbine6.2 Jacobsen’s Synthesis of (+)-Yohimbine6.3 Hiemstra’s Synthesis of (+)-Yohimbine6.4 Qin’s Synthesis of (–)-Yohimbine6.5 Tan’s Synthesis of (+)-Rauwolscine6.6 Jacobsen’s Synthesis of (+)-Reserpine6.7 Chen’s Synthesis of (+)-Reserpine6.8 Riva’s Synthesis of (–)-Alloyohimbane6.9 Katsuki’s Synthesis of (–)-Alloyohimbane6.10 Ghosh’s Synthesis of (–)-Yohimbane and (–)-Alloyohimbane6.11 Hong’s Synthesis of (–)-Yohimbane6.12 Gellman’s Synthesis of (–)-Yohimbane6.13 Scheidt’s Synthesis of (–)-Rauwolscine and (–)-Alloyohimbane7 Conclusion

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Yang, Mengquan, Bowen Yao, and Rongmei Lin. "Profiles of Metabolic Genes in Uncaria rhynchophylla and Characterization of the Critical Enzyme Involved in the Biosynthesis of Bioactive Compounds-(iso)Rhynchophylline." Biomolecules 12, no. 12 (November 30, 2022): 1790. http://dx.doi.org/10.3390/biom12121790.

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Rhynchophylline (RIN) and isorhynchophylline (IRN), two of the representative types of indole alkaloids, showed the unique spiroindole structures produced in Uncaria rhynchophylla. As the bioactive constituent of U. rhynchophylla, IRN has recently drawn extensive attention toward antihypertensive and neuroprotective activities. Despite their medicinal importance and unique chemical structure, the biosynthetic pathways of plant spiroindole alkaloids are still largely unknown. In this study, we used U. rhynchophylla, extensively used in traditional Chinese medicine (TCM), a widely cultivated plant of the Uncaria genus, to investigate the biosynthetic genes and characterize the functional enzymes in the spiroindole alkaloids. We aim to use the transcriptome platform to analyse the tissue-specific gene expression in spiroindole alkaloids-producing tissues, including root, bud, stem bark and leaf. The critical genes involved in the biosynthesis of precursors and scaffold formation of spiroindole alkaloids were discovered and characterized. The datasets from this work provide an essential resource for further investigating metabolic pathways in U. rhynchophylla and facilitate novel functional enzyme characterization and a good biopharming approach to spiroindole alkaloids.

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Cheng, Gui-Guang, Dan Li, Bo Hou, Xiao-Nian Li, Lu Liu, Ying-Ying Chen, Paul-Keilah Lunga, et al. "Melokhanines A–J, Bioactive Monoterpenoid Indole Alkaloids with Diverse Skeletons from Melodinus khasianus." Journal of Natural Products 79, no. 9 (September 2016): 2158–66. http://dx.doi.org/10.1021/acs.jnatprod.6b00011.

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-, Prabhavathi, and Anuradha Mal. "Nutraceutical properties of Vinca rosea." Biomedicine 42, no. 3 (July 3, 2022): 427–33. http://dx.doi.org/10.51248/.v42i3.1459.

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Vinca rosea (C. roseus), a member of the Apocynaceae family, is a popular medicinal plant found in many countries. It's gaining popularity because it's been discovered to have a variety of phytochemicals having a wide range of biological actions, such as free radicle scavenging, hypoglycemic, antibacterial, antifungal, and cancer-fighting properties. The most important alkaloids isolated from vinca plant is vincristine and vinblastine. These were the first anticancer medicines obtained from plants to be tested in clinical trials. New indole alkaloids have recently been identified from this plant, including human cancer cell lines which were efficiently suppressed in vitro by 14', 15'-didehydrocyclovinblastine, 17-deacetoxyvinamidine, and 17-deacetoxycyclovinblastine. This plant is high in alkaloids and other secondary metabolites. Vindoline, vindolidine, vindolicine, and vindolinine are some of the important alkaloids found in the leaf extracts of V. rosea which showed anti-diabetic activity in vitro. These findings imply that C. rosea remains a potential bioactive chemical source that warrants more investigation. This study gives a summary of the plant's botanical features, its traditional and current medical uses and phytochemical profiles. In addition, the extracts and bioactive components generated from this plant's supposed health advantages were investigated in order to establish its potential as medicinal agents.

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Jennings, Laurence K., Neyaz M. D. Khan, Navdeep Kaur, Daniel Rodrigues, Christine Morrow, Aoife Boyd, and Olivier P. Thomas. "Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola." Molecules 24, no. 21 (October 29, 2019): 3890. http://dx.doi.org/10.3390/molecules24213890.

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As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and chemical profiles. The first chemical investigation of this marine species led to the discovery of two new bisindole alkaloids of the topsentin family, together with six other known indole alkaloids. Missing the usual central core featured by the representatives of these marine natural products, the new metabolites may represent key biosynthetic intermediates for other known bisindoles. These compounds were found to exhibit weak cytotoxic activity against HeLa tumour cells, suggesting a specificity towards previously screened carcinoma and leukaemia cells.

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Chen, Min, Chang-Lun Shao, Xiu-Mei Fu, Ru-Fang Xu, Juan-Juan Zheng, Dong-Lin Zhao, Zhi-Gang She, and Chang-Yun Wang. "Bioactive Indole Alkaloids and Phenyl Ether Derivatives from a Marine-Derived Aspergillus sp. Fungus." Journal of Natural Products 76, no. 4 (March 25, 2013): 547–53. http://dx.doi.org/10.1021/np300707x.

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Yuan, Hai-Lian, Yun-Li Zhao, Xu-Jie Qin, Ya-Ping Liu, Hao-Fei Yu, Pei-Feng Zhu, Qiong Jin, Xing-Wei Yang, and Xiao-Dong Luo. "Anti-inflammatory and analgesic activities of Neolamarckia cadamba and its bioactive monoterpenoid indole alkaloids." Journal of Ethnopharmacology 260 (October 2020): 113103. http://dx.doi.org/10.1016/j.jep.2020.113103.

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Marques, Dayan de Araújo, Fernando Berton Zanchi, and Geisa Paulino Caprini Evaristo. "Ethnopharmacological review, phytochemistry and bioactivity of the genus Geissospermum (Apocynaceae)." Research, Society and Development 12, no. 2 (February 3, 2023): e18912240047. http://dx.doi.org/10.33448/rsd-v12i2.40047.

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This narrative review aims to update the ethnopharmacology, phytochemistry and biological activities of Geissospermum species described in the literature, in order to contribute to the knowledge of bioactive compounds of therapeutic interest and establish directions for future research with this genus. The term “Geissospermum” was used to perform searches in different databases such as NDLTD (Digital Library Network of Theses and Dissertations), Google Scholar, PubChem, Scifinder, Web of Science, SciELO, PubMed and Science Direct. Google's National Institute of Industrial Property and Patents (INPI) was also consulted. The keywords indole alkaloids, quina-quina, Geissospermum, Geissospermum reticulatum and malaria were used in the search. Publications in Portuguese, French, Spanish and English published between 1950 and 2022 were included. Indole alkaloids are the main secondary metabolites found in this genus, and several molecules have already been isolated, which may be related to the described pharmacological activities. Extracts and isolated compounds showed antitumor, antimalarial, antinociceptive, anti-inflammatory, anticholinesterase, anti-HIV, antimicrobial and antioxidant activity. Plants of the genus Geissospermum are used in Brazil mainly by the Amazonian peoples to treat various pathologies. Biological activities reported for extracts and isolated compounds are consistent with etonopharmacological use against malaria, cancer and other diseases. Future work with Geissospermum species is needed to elucidate the mechanism of action of the isolated alkaloids, as well as their toxicological profile.

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Nandagopal, Pavitra, Anthony Nyangson Steven, Liong-Wai Chan, Zaidah Rahmat, Haryati Jamaluddin, and Nur Izzati Mohd Noh. "Bioactive Metabolites Produced by Cyanobacteria for Growth Adaptation and Their Pharmacological Properties." Biology 10, no. 10 (October 18, 2021): 1061. http://dx.doi.org/10.3390/biology10101061.

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Cyanobacteria are the most abundant oxygenic photosynthetic organisms inhabiting various ecosystems on earth. As with all other photosynthetic organisms, cyanobacteria release oxygen as a byproduct during photosynthesis. In fact, some cyanobacterial species are involved in the global nitrogen cycles by fixing atmospheric nitrogen. Environmental factors influence the dynamic, physiological characteristics, and metabolic profiles of cyanobacteria, which results in their great adaptation ability to survive in diverse ecosystems. The evolution of these primitive bacteria resulted from the unique settings of photosynthetic machineries and the production of bioactive compounds. Specifically, bioactive compounds play roles as regulators to provide protection against extrinsic factors and act as intracellular signaling molecules to promote colonization. In addition to the roles of bioactive metabolites as indole alkaloids, terpenoids, mycosporine-like amino acids, non-ribosomal peptides, polyketides, ribosomal peptides, phenolic acid, flavonoids, vitamins, and antimetabolites for cyanobacterial survival in numerous habitats, which is the focus of this review, the bioactivities of these compounds for the treatment of various diseases are also discussed.

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Limbadri, Salendra, Xiaowei Luo, Xiuping Lin, Shengrong Liao, Junfeng Wang, Xuefeng Zhou, Bin Yang, and Yonghong Liu. "Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012." Molecules 23, no. 9 (September 18, 2018): 2379. http://dx.doi.org/10.3390/molecules23092379.

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Two new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-cephalosporin P1 (6) along with five known compounds (3–5, 7, 8) were isolated from deep-sea derived fungal Aspergillus fumigatus SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound 1 showed significant antifungal activity against Fusarium oxysporum f. sp. momordicae with MIC at 1.56 µg/mL. Compound 4 exhibited significant higher activity against S. aureus (16,339 and 29,213) with MIC values of 1.56 and 0.78 µg/mL, respectively, and compound 2 exhibited significant activity against A. baumanii ATCC 19606 with a MIC value of 6.25 µg/mL.

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Pham, Hong Ngoc Thuy, Quan Van Vuong, Michael C. Bowyer, and Christopher J. Scarlett. "Phytochemicals Derived from Catharanthus roseus and Their Health Benefits." Technologies 8, no. 4 (December 21, 2020): 80. http://dx.doi.org/10.3390/technologies8040080.

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Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Remarkably, vinblastine and vincristine isolated from this plant were the first plant-derived anticancer agents deployed for clinical use. Recently, new isolated indole alkaloids from this plant including catharoseumine, 14′,15′-didehydrocyclovinblastine, 17-deacetoxycyclovinblastine and 17-deacetoxyvinamidine effectively inhibited human cancer cell lines in vitro. Moreover, vindoline, vindolidine, vindolicine and vindolinine isolated from C. roseus leaf exhibited in vitro antidiabetic property. These findings strongly indicate that this plant is still a promising source of bioactive compounds, which should be further investigated. This paper provides an overview of the traditional use and phytochemical profiles of C. roseus, and summarises updated techniques of the preparation of dried material, extraction and isolation of bioactive compounds from this plant. In addition, purported health benefits of the extracts and bioactive compounds derived from this plant were also addressed to support their potential as therapeutic agents.

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Tlhapi, Dorcas, Isaiah Ramaite, Teunis Van Ree, Chinedu Anokwuru, Taglialatela-Scafati Orazio, and Heinrich Hoppe. "Isolation, Chemical Profile and Antimalarial Activities of Bioactive Compounds from Rauvolfia caffra Sond." Molecules 24, no. 1 (December 21, 2018): 39. http://dx.doi.org/10.3390/molecules24010039.

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In this study, the chemical profile of a crude methanol extract of Rauvolfia caffra Sond was determined by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Column chromatography and preparative thin layer chromatography were used to isolate three indole alkaloids (raucaffricine, N-methylsarpagine and spegatrine) and one triterpenoid (lupeol). The antiplasmodial activity was determined using the parasite lactate dehydrogenase (pLDH) assay. The UPLC-MS profile of the crude extract reveals that the major constituents of R. caffra are raucaffricine (m/z 513.2) and spegatrine (m/z 352.2). Fraction 3 displayed the highest antiplasmodial activity with an IC50 of 6.533 μg/mL. However, raucaffricine, isolated from the active fraction did not display any activity. The study identifies the major constituents of R. caffra and also demonstrates that the major constituents do not contribute to the antiplasmodial activity of R. caffra.

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Chen, Min, Chang-Lun Shao, Xiu-Mei Fu, Ru-Fang Xu, Juan-Juan Zheng, Dong-Lin Zhao, Zhi-Gang She, and Chang-Yun Wang. "Correction to Bioactive Indole Alkaloids and Phenyl Ether Derivatives from a Marine-Derived Aspergillus sp. Fungus." Journal of Natural Products 76, no. 6 (June 19, 2013): 1229. http://dx.doi.org/10.1021/np400465r.

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Pazos, Mariana, Estefania Dibello, Juan Manuel Mesa, Dalibor Sames, Marcelo Alberto Comini, Gustavo Seoane, and Ignacio Carrera. "Iboga Inspired N-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents." Molecules 27, no. 3 (January 27, 2022): 829. http://dx.doi.org/10.3390/molecules27030829.

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The first stage of the drug discovery process involves the identification of small compounds with biological activity. Iboga alkaloids are monoterpene indole alkaloids (MIAs) containing a fused isoquinuclidine-tetrahydroazepine ring. Both the natural products and the iboga-inspired synthetic analogs have shown a wide variety of biological activities. Herein, we describe the chemoenzymatic preparation of a small library of novel N-indolylethyl-substituted isoquinuclidines as iboga-inspired compounds, using toluene as a starting material and an imine Diels–Alder reaction as the key step in the synthesis. The new iboga series was investigated for its potential to promote the release of glial cell line-derived neurotrophic factor (GDNF) by C6 glioma cells, and to inhibit the growth of infective trypanosomes. GDNF is a neurotrophic factor widely recognized by its crucial role in development, survival, maintenance, and protection of dopaminergic neuronal circuitries affected in several neurological and psychiatric pathologies. Four compounds of the series showed promising activity as GDNF releasers, and a leading structure (compound 11) was identified for further studies. The same four compounds impaired the growth of bloodstream Trypanosoma brucei brucei (EC50 1–8 μM) and two of them (compounds 6 and 14) showed a good selectivity index.

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Ibrahim, Sabrin R. M., Sana A. Fadil, Haifa A. Fadil, Rawan H. Hareeri, Hossam M. Abdallah, and Gamal A. Mohamed. "Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities." Molecules 27, no. 18 (September 14, 2022): 5969. http://dx.doi.org/10.3390/molecules27185969.

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Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus Smenospongia (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolites with unique and unusual chemical skeletons, including terpenoids (sesqui-, di-, and sesterterpenoids), indole alkaloids, aplysinopsins, bisspiroimidazolidinones, chromenes, γ-pyrones, phenyl alkenes, naphthoquinones, and polyketides that possessed diversified bioactivities. This review provided an overview of the reported metabolites from Smenospongia sponges, including their biosynthesis, synthesis, and bioactivities in the period from 1980 to June 2022. The structural characteristics and diverse bioactivities of these metabolites could attract a great deal of attention from natural-product chemists and pharmaceuticals seeking to develop these metabolites into medicine for the treatment and prevention of certain health concerns.

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Lin, Li Ping, and Ren Xiang Tan. "Back Cover: Bioactive Alkaloids from Indole-3-carbinol Exposed Culture of Daldiniaeschscholzii (Chin. J. Chem. 8/2018)." Chinese Journal of Chemistry 36, no. 8 (July 13, 2018): 780. http://dx.doi.org/10.1002/cjoc.201880085.

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Liang, Chuxin, Chang Chen, Pengfei Zhou, Lv Xu, Jianhua Zhu, Jincai Liang, Jiachen Zi, and Rongmin Yu. "Effect of Aspergillus flavus Fungal Elicitor on the Production of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells." Molecules 23, no. 12 (December 11, 2018): 3276. http://dx.doi.org/10.3390/molecules23123276.

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This study reported the inducing effect of Aspergillus flavus fungal elicitor on biosynthesis of terpenoid indole alkaloids (TIAs) in Catharanthus roseus cambial meristematic cells (CMCs) and its inducing mechanism. According to the results determined by HPLC and HPLC-MS/MS, the optimal condition of the A. flavus elicitor was as follows: after suspension culture of C. roseus CMCs for 6 day, 25 mg/L A. flavus mycelium elicitor were added, and the CMC suspensions were further cultured for another 48 h. In this condition, the contents of vindoline, catharanthine, and ajmaline were 1.45-, 3.29-, and 2.14-times as high as those of the control group, respectively. Transcriptome analysis showed that D4H, G10H, GES, IRS, LAMT, SGD, STR, TDC, and ORCA3 were involved in the regulation of this induction process. The results of qRT-PCR indicated that the increasing accumulations of vindoline, catharanthine, and ajmaline in C. roseus CMCs were correlated with the increasing expression of the above genes. Therefore, A. flavus fungal elicitor could enhance the TIA production of C. roseus CMCs, which might be used as an alternative biotechnological resource for obtaining bioactive alkaloids.

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Patowary, Rimzim, and Chaman Lal Sharma. "ETHNOPHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USES OF OPHIORRHIZA MUNGOS LINN : A REVIEW." International Journal of Advanced Research 11, no. 03 (March 31, 2023): 230–35. http://dx.doi.org/10.21474/ijar01/16412.

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Ophiorrhiza mungos L, is an Ayurvedic herb ,belonging to the family Rubiaceae, commonly known asMongoose plant is an ethnobotanically important plant containing Camptothecin as a potent natural bioactive compound. The genus Ophiorrhiza is known to be a natural source of Camptothecin and diverse biological activities. Camptothecin (CPT), a cytotoxic quinoline indole alkaloid is an important source for the synthesis of some of the major anti-cancer agents such as irinotecan and topotecan. O.mungos is a plant which yields contain Camptothecin in a significantly high amount. The plant is gaining recognition due to its diversified medicinal value however it has been categorized as an endangered plant. Alternative method of propagation like tissue culture, cell suspension culture, root culture, seedling culture etc aims at large scale production of the plant. Scientific literature regarding the Ophiorrhiza plants revealed their wide distribution across Asia and the neighbouring countries, where they were utilised as traditional medicine to treat various diseases. Several secondary metabolites like alkaloids, flavonoids, steroids, terpenoids, and fatty acids etc, exhibiting anti- bacterial, anti-viral, anti-ulcer, anti-helminthic and anti-venom properties are extracted from various parts of the plant. Here we aim to provide an overview of the importance of Ophiorrhiza mungos , a member of genus Ophiorrhiza its botanical properties, phytochemical and pharmaceutical aspects with interest on camptothecin and its future prospects. The review is an attempt to provide insights in our gap of knowledge that needs concern and bridge the gaps between its bioactive compound, traditional uses and pharmacological activities in an approach to provide long term benefits to society.

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Estrada, Omar, Juan M. González-Guzmán, María M. Salazar-Bookman, Alfonso Cardozo, Eva Lucena, and Claudia P. Alvarado-Castillo. "Hypotensive and Bradycardic Effects of Quinovic Acid Glycosides from Aspidosperma fendleri in Spontaneously Hypertensive Rats." Natural Product Communications 10, no. 2 (February 2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000216.

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The Aspidosperma genus (Apocynaceae) represents one of the largest sources of indole alkaloids widely associated with cardiovascular effects. Aspidosperma fendleri, a plant found mainly in Venezuela, has a single phytochemical report in which is revealed the presence of alkaloids in its seeds. This study explored the cardiovascular effects of an ethanolic extract of A. fendleri leaves (EEAF) in spontaneously hypertensive rats (SHR) and its potential bioactive compounds. Using bioguided fractionation, fractions and pure compounds were intravenously administered to SHR and their effects on mean arterial blood pressure (MABP) and heart rate (HR) monitored over time. EEAF induced hypotensive and bradycardic effects as shown by significant reductions in mean arterial blood pressure (MABP) and heart rate (HR), respectively. Bioactivity-guided fractionation led to the isolation of a mixture of two known isomeric triterpenoid glycosides identified by spectral evidence as quinovic acid 3- O-β-rhamnopyranoside and quinovic acid 3- O-β-fucopyranoside. This mixture of triterpenoid saponins induced reductions in MABP and HR similar to those induced by propranolol. Together, these findings indicate that the two quinovic acid glycosides are responsible for the hypotensive and bradycardic effects which suggest their potential use in cardiovascular therapy.

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Journal articles on the topic 'Bioactive Indole Alkaloids'

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